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RESPIRATORY DISEASES (102 journals)                     

Showing 1 - 102 of 102 Journals sorted alphabetically
Advances in Respiratory Medicine     Open Access   (Followers: 7)
American Journal of Respiratory and Critical Care Medicine     Full-text available via subscription   (Followers: 253)
American Journal of Respiratory Cell and Molecular Biology     Full-text available via subscription   (Followers: 20)
American Review of Respiratory Disease     Full-text available via subscription   (Followers: 4)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1)
Annals of the American Thoracic Society     Full-text available via subscription   (Followers: 16)
Annals of Thoracic Medicine     Open Access   (Followers: 6)
Archivos de Bronconeumología     Full-text available via subscription  
Archivos de Bronconeumología (English Edition)     Full-text available via subscription   (Followers: 1)
Asthma Research and Practice     Open Access   (Followers: 1)
BMC Pulmonary Medicine     Open Access   (Followers: 4)
BMJ Open Respiratory Research     Open Access   (Followers: 5)
Breathe     Open Access   (Followers: 4)
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine     Hybrid Journal  
Canadian Respiratory Journal     Open Access   (Followers: 2)
Case Reports in Pulmonology     Open Access   (Followers: 3)
Chest     Full-text available via subscription   (Followers: 100)
Chest Disease Reports     Open Access   (Followers: 2)
Chronic Respiratory Disease     Hybrid Journal   (Followers: 9)
Clinical Lung Cancer     Hybrid Journal   (Followers: 5)
Clinical Medicine Insights : Circulatory, Respiratory and Pulmonary Medicine     Open Access   (Followers: 3)
Clinical Pulmonary Medicine     Hybrid Journal   (Followers: 2)
COPD Research and Practice     Open Access   (Followers: 1)
COPD: Journal of Chronic Obstructive Pulmonary Disease     Hybrid Journal   (Followers: 15)
Current Opinion in Pulmonary Medicine     Hybrid Journal   (Followers: 10)
Current Pulmonology Reports     Hybrid Journal  
Current Research in Tuberculosis     Open Access   (Followers: 3)
Current Respiratory Care Reports     Hybrid Journal   (Followers: 1)
Current Respiratory Medicine Reviews     Hybrid Journal   (Followers: 5)
Der Pneumologe     Hybrid Journal   (Followers: 1)
Egyptian Journal of Chest Diseases and Tuberculosis     Open Access   (Followers: 3)
ERJ Open Research     Open Access   (Followers: 2)
Eurasian Journal of Pulmonology     Open Access  
European Clinical Respiratory Journal     Open Access   (Followers: 3)
European Respiratory Journal     Full-text available via subscription   (Followers: 38)
European Respiratory Review     Open Access   (Followers: 7)
Experimental Lung Research     Hybrid Journal  
Expert Review of Respiratory Medicine     Hybrid Journal   (Followers: 5)
Heart & Lung: The Journal of Acute and Critical Care     Hybrid Journal   (Followers: 11)
Heart, Lung and Circulation     Full-text available via subscription   (Followers: 9)
Indian Journal of Respiratory Care     Open Access   (Followers: 3)
Indian Journal of Tuberculosis     Full-text available via subscription  
Influenza and Other Respiratory Viruses     Open Access   (Followers: 2)
International Journal of Chronic Obstructive Pulmonary Disease     Open Access   (Followers: 3)
Journal of Association of Chest Physicians     Open Access   (Followers: 2)
Journal of Asthma     Hybrid Journal   (Followers: 4)
Journal of Asthma Allergy Educators     Hybrid Journal   (Followers: 4)
Journal of Bronchology & Interventional Pulmonology     Hybrid Journal   (Followers: 3)
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases     Open Access  
Journal of Heart and Lung Transplantation     Hybrid Journal   (Followers: 12)
Journal of Respiratory Medicine     Open Access   (Followers: 4)
Journal of Respiratory Research     Open Access   (Followers: 1)
Journal of Tuberculosis Research     Open Access   (Followers: 1)
Jurnal Respirasi     Open Access  
Karger Kompass Pneumologie     Full-text available via subscription   (Followers: 1)
Kindheit und Entwicklung     Hybrid Journal  
Lung     Hybrid Journal   (Followers: 2)
Lung Cancer     Hybrid Journal   (Followers: 15)
Lung Cancer International     Open Access   (Followers: 2)
Lung Cancer: Targets and Therapy     Open Access   (Followers: 3)
Lung India     Open Access   (Followers: 1)
Multidisciplinary Respiratory Medicine     Open Access   (Followers: 4)
npj Primary Care Respiratory Medicine     Open Access   (Followers: 2)
Open Journal of Respiratory Diseases     Open Access   (Followers: 1)
Open Respiratory Medicine Journal     Open Access   (Followers: 1)
Paediatric Respiratory Reviews     Hybrid Journal   (Followers: 11)
Pediatric Quality & Safety     Open Access  
Pediatric Respirology and Critical Care Medicine     Open Access   (Followers: 1)
Pulmonary Circulation     Open Access   (Followers: 4)
Pulmonary Medicine     Open Access   (Followers: 2)
Pulmonary Pharmacology & Therapeutics     Hybrid Journal   (Followers: 2)
Pulmonary Therapy     Open Access   (Followers: 1)
Pulmonology and Respiratory Research     Open Access   (Followers: 1)
Respiratory Care     Full-text available via subscription   (Followers: 10)
Respiratory Investigation     Full-text available via subscription  
Respiratory Medicine     Hybrid Journal   (Followers: 17)
Respiratory Medicine : X     Open Access  
Respiratory Medicine Case Reports     Open Access  
Respiratory Medicine CME     Hybrid Journal  
Respiratory Medicine Extra     Full-text available via subscription   (Followers: 1)
Respiratory Physiology & Neurobiology     Hybrid Journal   (Followers: 4)
Respiratory Research     Open Access   (Followers: 1)
Respirology     Hybrid Journal   (Followers: 5)
Respirology Case Reports     Open Access  
Revista Americana de Medicina Respiratoria     Open Access  
Revista Chilena de Enfermedades Respiratorias     Open Access  
Revista Inspirar     Open Access  
Revista ORL     Open Access  
Revista Portuguesa de Pneumologia     Open Access  
Sarcoidosis Vasculitis and Diffuse Lung Disese     Full-text available via subscription   (Followers: 3)
Seminars in Respiratory and Critical Care Medicine     Hybrid Journal   (Followers: 14)
Sleep Medicine Reviews     Hybrid Journal   (Followers: 17)
The Clinical Respiratory Journal     Hybrid Journal   (Followers: 3)
The International Journal of Tuberculosis and Lung Disease     Full-text available via subscription   (Followers: 8)
The Lancet Respiratory Medicine     Full-text available via subscription   (Followers: 32)
Therapeutic Advances in Chronic Disease     Open Access   (Followers: 7)
Therapeutic Advances in Respiratory Disease     Open Access   (Followers: 1)
Thorax     Hybrid Journal   (Followers: 37)
Translational Respiratory Medicine     Open Access   (Followers: 1)
Tuberculosis     Hybrid Journal   (Followers: 12)
Tuberculosis Research and Treatment     Open Access   (Followers: 3)
Пульмонология     Full-text available via subscription  


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Revista Portuguesa de Pneumologia
Journal Prestige (SJR): 0.342
Citation Impact (citeScore): 1
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0873-2159 - ISSN (Online) 2173-5115
Published by Elsevier Homepage  [3161 journals]
  • Babylon Tower

    • Authors: N. Ambrosino
      Pages: 119 - 120
      Abstract: Publication date: May–June 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 3
      Author(s): N. Ambrosino

      PubDate: 2015-02-14T02:46:38Z
      DOI: 10.1016/j.rppneu.2014.04.001
  • End-of-life care in COPD: A survey carried out with Portuguese

    • Authors: C. Gaspar; S. Alfarroba; L. Telo; C. Gomes; C. Bárbara
      Pages: 123 - 130
      Abstract: Publication date: May–June 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 3
      Author(s): C. Gaspar , S. Alfarroba , L. Telo , C. Gomes , C. Bárbara
      Introduction End-of-life (EoL) care is a major component in the management of patients with advanced COPD. Patient-physician communication is essential in this process. Aim To evaluate the practice of Portuguese Pulmonologists in EoL communication and palliative care in COPD. Methods An on-line survey was sent to physicians affiliated to the Portuguese Pneumology Society. Results We obtained 136 answers from 464 eligible participants (29.3%). About half of the physicians reported that they have rarely introduced EoL discussions with their COPD patients (48.5%). Most had never/rarely suggested decision-making on the use of invasive mechanical ventilation (68.4%). Discussions were described as occurring mostly during/after a major exacerbation (53.7%). Only 37.5% of participants reported treating dyspnoea with opioids frequently/always. Only 9.6% stated that they never/rarely treated anxiety/depression. Most participants perceive the discussion of EoL issues as being difficult/very difficult (89.0%). The reasons most frequently given were feeling that patients were not prepared for this discussion (70.0%), fear of taking away a patient's hope (58.0%) and lack of training (51.0%). Conclusion Patient and medical staff EoL communication in COPD is still not good enough. Training in this area and the creation of formal protocols to initiate EoL have been identified as major factors for improvement.

      PubDate: 2015-02-14T02:46:38Z
      DOI: 10.1016/j.rppneu.2014.01.008
  • Factors that influence physical activity in the daily life of male
           patients with chronic obstructive pulmonary disease

    • Authors: S. Barriga; F. Rodrigues; C. Bárbara
      Pages: 131 - 137
      Abstract: Publication date: May–June 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 3
      Author(s): S. Barriga , F. Rodrigues , C. Bárbara
      Introduction Chronic obstructive pulmonary disease (COPD) is a disease with great impact on the ability to carry out physical activity. Objective To identify the main factors that affect physical activity in the daily life of patients with COPD. Methods Physical activity in daily routine has been evaluated according to the London Chest Activity of Daily Living scale (LCADL) and the pedometer counting the number of steps per day, for a period of three days. Fifty-five male patients with a diagnosis of moderate to very severe COPD were included (aged 67±9.6 years; FEV1 50.8±14.7% predicted). Results Patients walked on average 4972 steps per day. Very severe COPD patients (n =12) walked much less than severe (n =21) and moderate (n =22) patients (respectively 3079.8 versus 4853.5 and 6118.1 steps per day, p <0.001). The number of steps per day had a negative correlation with age, dyspnea (mMRC), depression, BODE index and pulmonary hyperinflation; and a positive correlation with the distance covered in the six-minute walk test (6MWT), forced expiratory volume in the first second (FEV1), carbon monoxide diffusion capacity (DLCO), arterial oxygen saturation (SpO2) and body mass index (BMI). Conclusions The main factors that correlated with limited physical activity in daily life routine of this group of COPD patients were dyspnea and 6min walking distance. These patients form a sedentary group, with a low rate of daily physical activity, which is more evident in patients with GOLD spirometry stage IV. Although pedometer is simpler and less accurate than other devices, it can be used to detect significant restraints daily life physical activity of COPD patients.

      PubDate: 2015-02-14T02:46:38Z
      DOI: 10.1016/j.rppneu.2013.09.004
  • Comparison between exercise performance in asthmatic children and healthy
           controls – Physical Activity Questionnaire application

    • Authors: Rita Santos-Silva; Cláudia Melo; Daniel Gonçalves; Janine Coelho; Fernanda Carvalho
      Pages: 138 - 145
      Abstract: Publication date: May–June 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 3
      Author(s): Rita Santos-Silva , Cláudia Melo , Daniel Gonçalves , Janine Coelho , Fernanda Carvalho
      Background The PAQ questionnaire (Physical Activity Questionnaire - Kowalski, Crocker, Donen) is a self-administered 7-day recall validated questionnaire that measures physical activity levels in young people. A final activity score is obtained (1 indicates low and 5 indicates high physical activity level). Our aim was to determine whether there was any difference between the level of physical activity of children with controlled allergic disease and healthy children. Patients and methods We used the PAQ questionnaire with a group of asthmatic children attending hospital outpatient clinic and a group of healthy children matched for age. Results 155 children with allergic disease (median age of 11 years; 63% males) and 158 healthy controls (median age of 10 years; 46% males) answered the questionnaire. There were no differences in the overall level of physical activity, estimated by PAQ score, between allergic and healthy children (2,40±0,7 vs 2,48±0,62; p=0,32). Performance in physical education classes and after school sports activity was found to be different between the study groups; healthy children were more active (p=0,011) and did more sports between 6 and 10 pm (p=0,036). No other statistically significant differences were found between the study groups. Conclusion Despite the fact that a majority of the parents of allergic children stated that their child's disease was a barrier to physical activity, in our study there seems to be no difference between the level of physical activity of controlled asthmatic children and their healthy peers.

      PubDate: 2015-02-14T02:46:38Z
      DOI: 10.1016/j.rppneu.2013.11.005
  • Non‐invasive ventilation in complex obstructive sleep apnea – A
           15‐year experience of a pediatric tertiary center

    • Authors: I.C. Girbal; C. Gonçalves; T. Nunes; R. Ferreira; L. Pereira; A. Saianda; T. Bandeira
      Pages: 146 - 151
      Abstract: Publication date: May–June 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 3
      Author(s): I.C. Girbal , C. Gonçalves , T. Nunes , R. Ferreira , L. Pereira , A. Saianda , T. Bandeira
      Introduction Obstructive sleep apnea (OSA) affects approximately 1–3% of pediatric population and is associated with significant morbidity. As adenotonsillar hypertrophy (ATH) is its primary cause in children, elective adenotonsillectomy is the first treatment of choice. Noninvasive ventilation (NIV) has been increasingly considered as an option, mainly for children with complex diseases, ineligible or waiting for surgeries, or after surgery failure. Objectives To describe the experience in the management of children with complex OSA, and to evidence the feasibility and advantages of NIV. Methods This was a retrospective cohort study of 68 children on NIV, in whom complex OSA was the main indication for ventilation, in a Pediatric Respiratory Unit at a University Hospital between January 1997 and March 2012. Demographic and clinical data were collected on the underlying diagnosis, therapeutic interventions prior to NIV, NIV related issues and outcome. Results Forty (59%) children were male, median age at starting NIV was 6 years and 7 months, with interquartile range (IQR) of 15–171 months. Twenty‐two (32%) were infants and 25 (37%) adolescents. The most common diagnosis was congenital malformations and genetic disorders in 34 (50%) patients. Nine patients had cerebral palsy, 8 were post treatment for central nervous system tumors and 6 had inborn errors of metabolism. Three children had ATH and three obesity. The majority of patients (76%) had exclusively obstructive OSA and started CPAP. Ten patients had minor complications. Twenty‐two patients stopped NIV due to clinical improvement, 8 were non‐compliant and 8 patients died. NIV median duration was 21.5 months (IQR: 7–72). Conclusions NIV is feasible and well tolerated by children with OSA associated with complex disorders, and has been shown to have few complications even in infants and toddlers.

      PubDate: 2015-02-14T02:46:38Z
      DOI: 10.1016/j.rppnen.2014.05.001
  • Prevention of ventilator-associated pneumonia

    • Authors: J. Oliveira; C. Zagalo; P. Cavaco-Silva
      Pages: 152 - 161
      Abstract: Publication date: May–June 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 3
      Author(s): J. Oliveira , C. Zagalo , P. Cavaco-Silva
      Invasive mechanical ventilation (IMV) represents a risk factor for the development of ventilator-associated pneumonia (VAP), which develops at least 48h after admission in patients ventilated through tracheostomy or endotracheal intubation. VAP is the most frequent intensive-care-unit (ICU)-acquired infection among patients receiving IMV. It contributes to an increase in hospital mortality, duration of MV and ICU and length of hospital stay. Therefore, it worsens the condition of the critical patient and increases the total cost of hospitalization. The introduction of preventive measures has become imperative, to ensure control and to reduce the incidence of VAP. Preventive measures focus on modifiable risk factors, mediated by non-pharmacological and pharmacological evidence based strategies recommended by guidelines. These measures are intended to reduce the risk associated with endotracheal intubation and to prevent microaspiration of pathogens to the lower airways.

      PubDate: 2015-02-14T02:46:38Z
      DOI: 10.1016/j.rppneu.2014.01.002
  • Clinical challenges of persistent pulmonary air-leaks—Case report

    • Authors: M. van Zeller; P. Bastos; G. Fernandes; A. Magalhães
      Pages: 162 - 166
      Abstract: Publication date: May–June 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 3
      Author(s): M. van Zeller , P. Bastos , G. Fernandes , A. Magalhães
      Air leaks are a common problem after pulmonary resection and can be a source of significant morbidity and mortality. The authors describe the case of a 68-year-old male patient who presented with a persistent air-leak after pulmonary resection. Watchful waiting, surgical procedures, as well as medical therapy like pleurodesis and implantation of endobronchial one-way valves on the bronchial segments identified using systematic occlusion of the bronchial segments, were all tried unsuccessfully. During that time the patient remained hospitalized with a chest tube. The instillation of methylene blue through the chest tube was used to identify the segments leading to the persistent air-leak; this enabled successful endobronchial valve placement which sufficiently reduced the size of the air-leak so that the chest tube could be removed. Nonsurgical approaches seem promising and, for some patients may be the only treatment option after all conventional treatments have failed or are considered too high risk.

      PubDate: 2015-02-14T02:46:38Z
      DOI: 10.1016/j.rppnen.2013.07.008
  • Fístula arterio-arterial entre a artéria pulmonar e artérias
           intercostais – a propósito de um caso clínico de «unilateral rib

    • Authors: F. Morais; T. Almeida; P. Campos
      Pages: 167 - 171
      Abstract: Publication date: May–June 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 3
      Author(s): F. Morais , T. Almeida , P. Campos
      Os autores apresentam um caso clínico de um doente de 35 anos a quem foi efetuado o diagnóstico de fístula arterio-arterial sistémico-pulmonar e fazem uma revisão da literatura sobre fístulas arterio-arteriais sistémico-pulmonares baseado nos achados radiológicos de um caso excecional. The authors present a clinical case of a 35-year-old patient who was diagnosed with intercostal artery-to-pulmonary artery fistula and review the literature of systemic-to- pulmonary fistulae based on radiological findings of an exceptional case report.

      PubDate: 2015-02-14T02:46:38Z
      DOI: 10.1016/j.rppneu.2013.08.004
  • BCGitis in children

    • Authors: I. Ladeira; I. Carvalho; A. Correia; A. Carvalho; R. Duarte
      Pages: 172 - 173
      Abstract: Publication date: May–June 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 3
      Author(s): I. Ladeira , I. Carvalho , A. Correia , A. Carvalho , R. Duarte

      PubDate: 2015-02-14T02:46:38Z
      DOI: 10.1016/j.rppneu.2013.12.003
  • Lung volumes in the pathogenesis of obstructive sleep apnea

    • Authors: R. Reis; A. Antunes
      Pages: 173 - 174
      Abstract: Publication date: May–June 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 3
      Author(s): R. Reis , A. Antunes

      PubDate: 2015-02-14T02:46:38Z
      DOI: 10.1016/j.rppneu.2014.01.005
  • CT-guided transthoracic lung biopsy: Predictive factors of pneumothorax

    • Authors: J.F. Cruz; R. Rolo; L. Iglésias; J. Cunha
      Pages: 174 - 176
      Abstract: Publication date: May–June 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 3
      Author(s): J.F. Cruz , R. Rolo , L. Iglésias , J. Cunha

      PubDate: 2015-02-14T02:46:38Z
      DOI: 10.1016/j.rppnen.2014.01.006
  • What we have accomplished and what we can achieve

    • Authors: Morais
      Abstract: Publication date: March–April 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 2
      Author(s): A. Morais

      PubDate: 2015-02-20T13:16:50Z
  • Run for your life!

    • Authors: Moreira
      Abstract: Publication date: May–June 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 3
      Author(s): André Moreira

      PubDate: 2015-02-14T02:46:38Z
  • Brazilian Journal of Pulmonology and Portuguese Journal of Pulmonology:
           Strengthening ties in respiratory science

    • Authors: Rogerio Souza; Carlos Roberto Ribeiro de Carvalho
      Pages: 285 - 286
      Abstract: Publication date: November–December 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 6
      Author(s): Rogerio Souza , Carlos Roberto Ribeiro de Carvalho

      PubDate: 2014-12-13T17:19:00Z
      DOI: 10.1016/j.rppneu.2014.11.001
  • Tobacco control progress in Portugal: The need for advocacy and civil
           society leadership

    • Authors: S.B. Ravara; N. Miranda; J.M. Calheiros; F. Berteletti; L. Joossens
      Pages: 289 - 292
      Abstract: Publication date: Available online 11 October 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): S.B. Ravara , N. Miranda , J.M. Calheiros , F. Berteletti , L. Joossens

      PubDate: 2014-10-12T17:47:11Z
      DOI: 10.1016/j.rppneu.2014.09.003
  • Nutritional Screening of Pulmonology Department Inpatients

    • Authors: Isabel Maia; Sónia Xará; Isabel Dias; Bárbara Parente; Teresa F. Amaral
      Pages: 293 - 298
      Abstract: Publication date: November–December 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 6
      Author(s): Isabel Maia , Sónia Xará , Isabel Dias , Bárbara Parente , Teresa F. Amaral
      Undernutrition is associated with worse clinical outcomes and so screening is recommended. Given the paucity of information on nutritional status and on the clinical impact of undernutrition in Pulmonology patients who have been hospitalized, it is of the utmost importance that it is studied. Through a longitudinal study conducted of 323 patients consecutively admitted to a Pulmonology hospital department, undernutrition was screened using the Malnutrition Universal Screening Tool and the association between length of hospital stay, pathology type, discharge destination and undernutrition risk was quantified. There was found to be a high proportion of patients at risk of undernutrition, with 18.3% at high risk and 15.5% at moderate risk. Patients at risk of undernutrition had a higher risk of dying during hospitalization (OR=2.72, 95% CI: 1.48- 4.97). One in three patients admitted to this unit is at risk of undernutrition; chronic obstructive pulmonary disease was the pathology most strongly associated with undernutrition risk. Present data reinforces the need for screening for undernutrition on admission.

      PubDate: 2014-12-13T17:19:00Z
      DOI: 10.1016/j.rppneu.2014.01.004
  • Effect of a Pulmonary Rehabilitation Program on the levels of anxiety and
           depression and on the quality of life of patients with chronic obstructive
           pulmonary disease

    • Authors: C.C. da Costa; C. de Azeredo Lermen; C. Colombo; D.B. Canterle; M.L.L. Machado; A. Kessler; P.J.Z. Teixeira
      Pages: 299 - 304
      Abstract: Publication date: Available online 27 May 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): C.C. da Costa , C. de Azeredo Lermen , C. Colombo , D.B. Canterle , M.L.L. Machado , A. Kessler , P.J.Z. Teixeira
      Objective To analyze the effect of a Pulmonary Rehabilitation Program (PRP) on the levels of anxiety and depression and the quality of life of patients with chronic obstructive pulmonary disease. Method Patients with chronic obstructive pulmonary disease (COPD) who completed the PRP of 3 weekly sessions of 60min duration for 12 weeks, a total of 36 sessions, were assessed using Beck Inventory (BAI and BDI) and Saint George's Respiratory Questionnaire (SGRQ). Results A total of 125 individuals, with an average age of 63.7±8.8 years, FEV1: 1.17±0.57L (43.18±18.79% predicted), 61.6% male and 38.4% female, were analyzed. The BAI and BDI before and after PRP were, respectively, 10.15±6.32 vs. 7.67±7.21; p =0.0041 and 12.60±7.99 vs. 8.96±7.29; p =0.00016. The results of the SGRQ domains were, respectively, Before and After symptoms (48.53±20.41 vs. 32.58±18.95), Activity (69.15±20.79 vs. 52.42±23.70), Impact (32.92±18.29 vs. 20.27±16.70), Total (46.69±16.90 vs. 32.07±16.96). When correlating the BDI to the domains of the SGRQ, weak correlations were observed (Symptoms r =0.22; p =0.01; Activity r =0.28; p =0.001; Impact r =0.52; p =2.72; Total r =0.44; p =0.17). In the same way, weak correlations were observed when correlating the BAI to the SGRQ (Symptoms r =0.28; p =0.0009; Activity r =0.32; p =0.0005; Impact r =0.42; p =7.33; Total r =0.43; p =0.74). Conclusion Although the PRP improves levels of depression and anxiety as well as the quality of life in patients with COPD, no significant correlation of these analyzed variables was observed.

      PubDate: 2014-06-02T11:15:26Z
      DOI: 10.1016/j.rppneu.2014.03.007
  • Is TNF-α gene polymorphism related to pulmonary functions and prognosis
           as determined by FEV1, BMI, COPD exacerbation and hospitalization in
           patients with smoking-related COPD in a Turkish population'

    • Authors: Nezihe Özdoğan; Nuri Tutar; Ramazan Demir; Çetin Saatçi; Asiye Kanbay; Hakan Büyükoğlan
      Pages: 305 - 310
      Abstract: Publication date: Available online 10 May 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): Nezihe Özdoğan , Nuri Tutar , Ramazan Demir , Çetin Saatçi , Asiye Kanbay , Hakan Büyükoğlan
      Introduction Some conflicting results have been published about the relationship between TNF-α-308 gene polymorphism and chronic obstructive pulmonary disease (COPD). The aim of this study was to determine whether TNF-α-308 gene polymorphism was associated with smoking-related COPD and whether it was associated with pulmonary function parameters (PFTs), body mass index (BMI), and prognosis. Methods We studied the frequencies of TNF-α-308 gene polymorphism in 90 male subjects (60 subjects with COPD and 30 healthy smokers) in a Caucasian population. Results There was no significant difference in the frequency of G/G and G/A gene polymorphisms in the COPD group compared with control subjects (p >0.05). We compared COPD patients as G/A gene polymorphism and G/G gene polymorphism; the PFTs and BMI before and after one year were not statistically significant (p >0.05). Also, the exacerbation and hospitalization data of COPD patients were not significant between these groups. Conclusion In conclusion, there was no difference between smoking-related COPD and the control group according to TNF α-308 gene polymorphism in a Caucasian population. In addition, it was shown that important determinants of prognosis of COPD such as FEV1, BMI, COPD exacerbation and hospitalization were not associated with TNF-α-308 gene polymorphism.

      PubDate: 2014-05-15T11:28:06Z
      DOI: 10.1016/j.rppneu.2014.03.003
  • Environment and Health in Children Day Care Centres (ENVIRH) – Study
           rationale and protocol

    • Authors: J. Araújo-Martins; P. Carreiro Martins; J. Viegas; D. Aelenei; M.M. Cano; J.P. Teixeira; P. Paixão; A.L. Papoila; P. Leiria-Pinto; C. Pedro; J. Rosado-Pinto; I. Annesi-Maesano; N. Neuparth
      Pages: 311 - 323
      Abstract: Publication date: November–December 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 6
      Author(s): J. Araújo-Martins , P. Carreiro Martins , J. Viegas , D. Aelenei , M.M. Cano , J.P. Teixeira , P. Paixão , A.L. Papoila , P. Leiria-Pinto , C. Pedro , J. Rosado-Pinto , I. Annesi-Maesano , N. Neuparth
      Background Indoor air quality (IAQ) is considered an important determinant of human health. The association between exposure to volatile organic compounds, particulate matter, house dust mite, molds and bacteria in day care centers (DCC) is not completely clear. The aim of this project was to study these effects. Methods – study design This study comprised two phases. Phase I included an evaluation of 45 DCCs (25 from Lisbon and 20 from Oporto, targeting 5161 children). In this phase, building characteristics, indoor CO2 and air temperature/relative humidity, were assessed. A children's respiratory health questionnaire derived from the ISAAC (International Study on Asthma and Allergies in Children) was also distributed. Phase II encompassed two evaluations and included 20 DCCs selected from phase I after a cluster analysis (11 from Lisbon and 9 from Oporto, targeting 2287 children). In this phase, data on ventilation, IAQ, thermal comfort parameters, respiratory and allergic health, airway inflammation biomarkers, respiratory virus infection patterns and parental and child stress were collected. Results In Phase I, building characteristics, occupant behavior and ventilation surrogates were collected from all DCCs. The response rate of the questionnaire was 61.7% (3186 children). Phase II included 1221 children. Association results between DCC characteristics, IAQ and health outcomes will be provided in order to support recommendations on IAQ and children's health. A building ventilation model will also be developed. Discussion This paper outlines methods that might be implemented by other investigators conducting studies on the association between respiratory health and indoor air quality at DCC.

      PubDate: 2014-12-13T17:19:00Z
      DOI: 10.1016/j.rppneu.2014.02.006
  • Non-invasive ventilation in the treatment of sleep-related breathing
           disorders: A review and update

    • Authors: A. Nicolini; P. Banfi; B. Grecchi; A. Lax; S. Walterspacher; C. Barlascini; D. Robert
      Pages: 324 - 335
      Abstract: Publication date: Available online 20 June 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): A. Nicolini , P. Banfi , B. Grecchi , A. Lax , S. Walterspacher , C. Barlascini , D. Robert
      Non-invasive mechanical ventilation (NIV) was originally used in patients with acute respiratory compromises or exacerbations of chronic respiratory diseases as an alternative to intubation. Over the last thirty years NIV has been used during the night in patients with stable chronic lung diseases such as obstructive sleep apnea, the overlap syndrome (COPD and obstructive sleep apnea), neuromuscular disorders, obesity-hypoventilation syndrome and in other conditions such as sleep disorders associated with congestive heart failure. In this review we discuss the different types of NIV, the specific conditions in which they can be used as well as the indications, recommendations, and evidence supporting the efficacy of NIV.

      PubDate: 2014-07-27T14:29:43Z
      DOI: 10.1016/j.rppneu.2014.03.009
  • Neonatal extracorporeal membrane oxygenation: Initial experience of
           Hospital de São João

    • Authors: G. Rocha; P. Soares; T. Henriques-Coelho; J. Correia-Pinto; J. Monteiro; H. Guimarães; R. Roncon-Albuquerque
      Pages: 336 - 340
      Abstract: Publication date: November–December 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 6
      Author(s): G. Rocha , P. Soares , T. Henriques-Coelho , J. Correia-Pinto , J. Monteiro , H. Guimarães , R. Roncon-Albuquerque Jr.
      The purpose of this series is to report the initial ECMO experience of the Neonatal Intensive Care Unit of Hospital de São João. The first three clinical cases are reported. Case report 1: a 39 weeks gestational age girl with severe lung hypoplasia secondary to a bilateral congenital diaphragmatic hernia. Case report 2: a 39 weeks gestational age girl with a right congenital diaphragmatic hernia and a tracheal stenosis. Case report 3: a 34 weeks gestational age boy, with 61 days of life, with a Bordetella pertussis pneumonia, severe pulmonary hypertension, shock, hyperleukocytosis and seizures.

      PubDate: 2014-12-13T17:19:00Z
      DOI: 10.1016/j.rppneu.2014.02.004
  • End-stage silicosis and lung transplantation: A way forward

    • Authors: M.T. Redondo; M. Vaz; C. Damas
      First page: 341
      Abstract: Publication date: Available online 11 October 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): M.T. Redondo , M. Vaz , C. Damas

      PubDate: 2014-10-12T17:47:11Z
      DOI: 10.1016/j.rppneu.2014.09.004
  • Obstructive sleep apnea in women: Prevalence, risk factors and relation to
           menopausal status

    • Authors: A. Tavares e Castro; J.C. Duarte; J. Cravo; S. Freitas; M.J. Matos
      Pages: 342 - 343
      Abstract: Publication date: Available online 3 October 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): A. Tavares e Castro , J.C. Duarte , J. Cravo , S. Freitas , M.J. Matos

      PubDate: 2014-10-10T08:57:58Z
      DOI: 10.1016/j.rppneu.2014.07.003
  • Diagnosis of pulmonary sequestration using imaging methods

    • Authors: Rita Gomes; Filomena Luís; Madalena Reis
      Pages: 343 - 344
      Abstract: Publication date: Available online 29 August 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): Rita Gomes , Filomena Luís , Madalena Reis

      PubDate: 2014-09-05T11:20:37Z
      DOI: 10.1016/j.rppneu.2014.07.002
  • Endobronchial ultrasound in sarcoidosis: Time to rethink the diagnostic

    • Authors: A. Bugalho; A. Szlubowski
      Pages: 235 - 236
      Abstract: Publication date: Available online 2 July 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): A. Bugalho , A. Szlubowski

      PubDate: 2014-07-27T14:29:43Z
      DOI: 10.1016/j.rppneu.2014.05.003
  • Diagnosis of sarcoidosis in the Endobronchial Ultrasound-guided
           Transbronchial Needle Aspiration era

    • Authors: C. Ribeiro; A. Oliveira; S. Neves; S. Campainha; C. Nogueira; S. Torres; M.C. Brito; J. Almeida; J.M. e Sá
      Pages: 237 - 241
      Abstract: Publication date: Available online 1 May 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): C. Ribeiro , A. Oliveira , S. Neves , S. Campainha , C. Nogueira , S. Torres , M.C. Brito , J. Almeida , J.M. e Sá
      Background Sarcoidosis is a multisystemic disorder of unknown etiology. Its diagnosis is based on compatible clinical and radiological features and supported by histological demonstration of epithelioid cell noncaseating granulomas with exclusion of other causes. Endobronchial ultrasound combined with transbronchial needle aspiration (EBUS-TBNA) has been proposed as a valuable tool in obtaining suitable tissue sample. The aim of this study was to evaluate the contribution of EBUS-TBNA to the diagnosis of stages I and II thoracic sarcoidosis in a community-based hospital. Methods A prospective study was conducted in patients with suspected stages I and II pulmonary sarcoidosis, based on clinical and radiological data, who were being followed in our Interstitial Lung Disorders Outpatient Clinic or sent from other hospitals to our Respiratory Endoscopy Unit for diagnostic procedures. All suitable and fit patients underwent EBUS-TBNA between March 2010 and June 2013. We assessed demographic characteristics, radiological stages, cytological/histological examination and diagnostic techniques performed. Results In the period considered 39 patients underwent EBUS-TBNA for suspected stages I and II thoracic sarcoidosis and adequate samples were obtained in 38 (97.4%). Within this population, 33 (84.6%) patients had a definite diagnosis of sarcoidosis, of which 31 patients (93.9%) were confirmed to have epithelioid noncaseating granulomas by EBUS-TBNA. Four patients were submitted to surgical procedures (three to mediastinoscopy and one to open surgical lung biopsy). Data analysis allowed to calculate a sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of 93.9%, 100%, 100%, 75.0% and 94.8%, respectively. No complications were observed. Conclusions EBUS-TBNA is a valuable tool in the diagnostic workup of patients with suspected stages I and II thoracic sarcoidosis providing a substantial number of pathological confirmations and with few complications. Its high diagnostic accuracy precludes the need for more invasive procedures such as surgical biopsy.

      PubDate: 2014-05-05T16:22:23Z
      DOI: 10.1016/j.rppneu.2014.02.005
  • Tuberculosis: Which patients do not identify their contacts?

    • Authors: J. Josaphat; J. Gomes Dias; S. Salvador; V. Resende; R. Duarte
      Pages: 242 - 247
      Abstract: Publication date: September–October 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 5
      Author(s): J. Josaphat , J. Gomes Dias , S. Salvador , V. Resende , R. Duarte
      Setting It is not known what the magnitude of non‐identified TB contacts is in our country, or the reasons why contacts at risk are not identified. Objective The purpose of this study was to analyze the determinants associated with non‐identification of contacts. Design This cross‐sectional study included all cases of pulmonary tuberculosis diagnosed and treated in the Chest Disease Centre of Vila Nova de Gaia and their contacts, from 1st January to 31st December 2010. It included information collected from patients related to the identification of contacts in risk, and the information collected by the Public Health Unit during home, work and social places visits. Results During the period of study, 61 cases of pulmonary TB were diagnosed: 41 cases (67.2%) identified all their contacts and 20 cases (32.8%) did not. 646 contacts were identified: 154 (23.8%) were identified only by the Public Health Unit (mean age of 40.67), and 492 (76.2%) were identified by the index cases (mean age of 33.25), (p =0.001). A mean of 10.59 contacts were identified per index case, of which, 83 (19.3%) screened positive. From those identified by the Public Health Unit, 10 (9.8%) had LTBI and 5 (4.9%) had active TB, and by the index case 61 (18.6%) had LTBI and 7 (2.1%) had active TB (crude OR=1.52; CI=0.83–2.79). The multivariate analysis showed that employment (adjusted OR=4.82; 95%CI=1.71–13.54) was associated to non‐identification of contacts and patients preferably tended to identify relatives and co‐habitants (adjusted OR=0.22; 95%CI=0.10–0.47). Conclusion TB patients tend to identify relatives and co‐habitant contacts; contact at place of employment was found to be an independent risk factor for not being identified.

      PubDate: 2014-09-05T11:20:37Z
      DOI: 10.1016/j.rppneu.2013.11.004
  • An investigation into the relationship between region specific quality of
           life and adverse tuberculosis treatment outcomes in Istanbul, Turkey

    • Authors: A. Babalik; S. Kiziltas; S. Gencer; Z. Kilicaslan
      Pages: 248 - 253
      Abstract: Publication date: Available online 24 March 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): A. Babalik , S. Kiziltas , S. Gencer , Z. Kilicaslan
      Background and objective Istanbul has the highest incidence of tuberculosis (TB) in Turkey. It is also the largest city, with considerable differences in quality of life across its urban regions. The aim of this study is to investigate the relationship between (i) the diverse quality of life across specific urban regions, (ii) TB incidence rates, inclusive of demographic and clinical characteristics of TB patients, and (iii) adverse treatment outcomes. Methods This retrospective study included 23,845 new TB patients (recorded in the National TB Registry between 2006 and 2010) in Istanbul. Thirty-nine urban districts of Istanbul were ranked into five groups on the basis of an urban quality of life index. Patient data were matched with these groups, and further categorized according to ‘age’, ‘sex’, ‘country of birth’ and ‘antibiotics resistance’. Adverse treatment outcomes and TB incidence rates were extracted from official records. Logistic regression, clustered analyses, 95% CI and p values (STATA) were reported to describe the association between variables. Results Six per cent of total cases had ‘at least one adverse treatment outcome’ (default 3.8%, failure 0.5%, death 1.7% in total cases). ‘An adverse treatment outcome’ was found to be associated with age OR (CI 95%) (1.02 (1.01–1.03)); ‘male sex’ 1.65 (1.28–2.12); ‘other country of birth’ 4.82 (3.05–7.62); 100,000 per ‘over 60’ insidence goups 1.61 (1.32-1.97), the lowest quality of life index 0.65 (0.47-0.83). Conclusions Patients with high tuberculosis risk factors living in high incidence regions need to be closely monitored. Patients living in lower ranking regions are more likely to have ‘poor treatment outcomes’.

      PubDate: 2014-03-24T17:29:03Z
      DOI: 10.1016/j.rppneu.2014.01.003
  • Bilateral whole lung lavage in pulmonary alveolar proteinosis – A
           retrospective study

    • Authors: A. Silva; A. Moreto; C. Pinho; A. Magalhães; A. Morais; C. Fiuza
      Pages: 254 - 259
      Abstract: Publication date: Available online 18 July 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): A. Silva , A. Moreto , C. Pinho , A. Magalhães , A. Morais , C. Fiuza
      Whole lung lavage (WLL) is the gold standard technique for the treatment of Pulmonary Alveolar Proteinosis (PAP). In this paper we evaluated and discuss bilateral WLL, namely the procedure work-up and the therapeutic efficacy. Six bilateral WLL performed through a careful adherence to a modified Royal Brompton Hospital (London) technique were carried out without major complications and were associated with clinical and functional improvement of the PAP patients submitted to this procedure. As there are benefits in terms of time, patient comfort and cost effectiveness compared to unilateral WLL, associated with the efficacy and safety observed, bilateral WLL seems to be a suitable first choice for therapeutic lavage in PAP patients.

      PubDate: 2014-07-27T14:29:43Z
      DOI: 10.1016/j.rppneu.2014.04.004
  • Spectrometric analysis and scanning electronic microscopy of two pleural
           plaques from mediaeval Portuguese period

    • Authors: T. Fernandes; R. Granja; P.L. Thillaud
      Pages: 260 - 263
      Abstract: Publication date: Available online 21 June 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): T. Fernandes , R. Granja , P.L. Thillaud
      During an archaeological excavation at a mediaeval monastery (Flor da Rosa, Crato, Portugal), a skeleton of a adult woman was found with two calcifications in the thoracic cage. The location and the macroscopic analysis of the calcifications allowed them to be assigned as pleural plaques. Spectrometric analysis and scanning electronic microscopy enabled to establish that it originated with an infectious process. These results associated with the lesions found in the ribs and vertebrae strongly suggest tuberculosis as the cause of these pleural plaques.

      PubDate: 2014-07-27T14:29:43Z
      DOI: 10.1016/j.rppneu.2014.01.006
  • Prolonged weaning: From the intensive care unit to home

    • Authors: P. Navalesi; P. Frigerio; A. Patzlaff; S. Häußermann; P. Henseke; M. Kubitschek
      Pages: 264 - 272
      Abstract: Publication date: Available online 26 June 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): P. Navalesi , P. Frigerio , A. Patzlaff , S. Häußermann , P. Henseke , M. Kubitschek
      Weaning is the process of withdrawing mechanical ventilation which starts with the first spontaneous breathing trial (SBT). Based on the degree of difficulty and duration, weaning is classified as simple, difficult and prolonged. Prolonged weaning, which includes patients who fail 3 SBTs or are still on mechanical ventilation 7 days after the first SBT, affects a relatively small fraction of mechanically ventilated ICU patients but these, however, requires disproportionate resources. There are several potential causes which can lead to prolonged weaning. It is nonetheless important to understand the problem from the point of view of each individual patient in order to adopt appropriate treatment and define precise prognosis. An otherwise stable patient who remains on mechanical ventilation will be considered for transfer to a specialized weaning unit (SWU). Though there is not a precise definition, SWU can be considered as highly specialized and protected environments for patients requiring mechanical ventilation despite resolution of the acute disorder. Proper staffing, well defined short-term and long-term goals, attention to psychological and social problems represent key determinants of SWU success. Some patients cannot be weaned, either partly or entirely, and may require long-term home mechanical ventilation. In these cases the logistics relating to caregivers and the equipment must be carefully considered and addressed.

      PubDate: 2014-07-27T14:29:43Z
      DOI: 10.1016/j.rppneu.2014.04.006
  • A novel immunodeficiency syndrome as a rare cause of secondary pulmonary
           alveolar proteinosis: A diagnosis after 5 decades

    • Authors: Pedro G. Ferreira; Lina Carvalho; Fernanda Gamboa
      Pages: 273 - 278
      Abstract: Publication date: Available online 13 April 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): Pedro G. Ferreira , Lina Carvalho , Fernanda Gamboa
      Case report of a male patient with a five-decade follow-up history in a tertiary care hospital distinguished for malabsorption syndrome, failure-to-thrive, meningitis and recurrent bacterial, fungal and mycobacterial pulmonary infections. Additionally, he developed epidermodysplasia verruciformis, several in situ spinocellular carcinomas and an uncharacteristic parenchymal lung disease. Surgical lung biopsy suggested pulmonary alveolar proteinosis with fibrotic change. Retrospectively, severe monocytopenia had been overlooked in the past, as well as low B and NK cell blood counts. Flow cytometry confirmed the absence of the previous cell subsets along with an undetectable population of dendritic blood cells. Dendritic cell, monocyte, B and NK lymphoid Human Deficiency Syndrome (DCMLS) is a novel rare immunodeficiency described in 2010, linked to GATA-2 mutation. This syndrome should be highlighted as a rare cause of acquired PAP, with a radiological pattern encompassing potential fibrotic change. Failure to recognize monocytopenia may impede the chance to diagnose.

      PubDate: 2014-04-15T06:25:29Z
      DOI: 10.1016/j.rppneu.2013.08.006
  • Thoracic paraganglioma diagnosed in a patient with pulmonary tuberculosis
           – Case report

    • Authors: J.F. Cruz; L. Iglésias; M. Monteiro; M.J. Santos; T. Pimentel; R.P. Silva
      Pages: 279 - 281
      Abstract: Publication date: Available online 26 June 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): J.F. Cruz , L. Iglésias , M. Monteiro , M.J. Santos , T. Pimentel , R.P. Silva

      PubDate: 2014-07-27T14:29:43Z
      DOI: 10.1016/j.rppneu.2014.04.003
  • Ethical limits for noninvasive ventilation prescription

    • Authors: M. Simões Saldanha Mendes; C. Ferreira; C. Dias; J. Moita
      Pages: 281 - 282
      Abstract: Publication date: Available online 16 May 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): M. Simões Saldanha Mendes , C. Ferreira , C. Dias , J. Moita

      PubDate: 2014-05-20T11:22:08Z
      DOI: 10.1016/j.rppneu.2014.03.006
  • Towards a 100% smoke-free Portugal: No more delays

    • Authors: S.B. Ravara; N. Miranda; J.M. Calheiros
      Pages: 282 - 283
      Abstract: Publication date: Available online 6 August 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): S.B. Ravara , N. Miranda , J.M. Calheiros

      PubDate: 2014-08-10T01:49:46Z
      DOI: 10.1016/j.rppneu.2014.06.002
  • ALS: Control ventilation, manage respiratory secretions and, when
           required, oversee the process of dying

    • Authors: Emilio Servera; Jesús Sancho
      Pages: 177 - 178
      Abstract: Publication date: July–August 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 4
      Author(s): Emilio Servera , Jesús Sancho

      PubDate: 2014-07-27T14:29:43Z
      DOI: 10.1016/j.rppnen.2014.05.002
  • Pilot study for home monitoring of cough capacity in amyotrophic lateral
           sclerosis: A case series

    • Authors: M. Paneroni; D. Trainini; J.C. Winck; M. Vitacca
      Pages: 181 - 187
      Abstract: Publication date: Available online 1 February 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): M. Paneroni , D. Trainini , J.C. Winck , M. Vitacca
      Background Cough capacity derangement is associated with a high risk of pulmonary complications in amyotrophic lateral sclerosis patients when cough assistance is not routinely performed at home. The primary aim of this study was to evaluate the feasibility of a long‐term home based daily self‐monitoring cough capacity. Methods Eighteen subjects were enrolled in a 9‐month study at home. Changes in peak cough expiratory flow, oxygen saturation, respiratory discomfort and incidence of respiratory deterioration events were evaluated. In subjects presenting respiratory deterioration events, decline in the abovementioned respiratory variables was evaluated (#NCT00613899). Results During an average follow‐up of 125±102 days, a total of 1175 measures were performed on 12 subjects. Mean compliance to proposed evaluations was 37±32% which worsened over time. Peak cough expiratory flow decreased by 15.08±32.43L/min monthly. Five subjects reported 6 episodes of respiratory deterioration events, after a mean period of 136±108 days. They had poor respiratory function and more years of disease. There was no difference in peak cough expiratory flow and its decline whether subjects presented respiratory deterioration events or not. In 4 subjects the respiratory discomfort score significantly worsened after respiratory deterioration events from 3.0±1.41 to 4.25±1.71. Conclusion Daily self‐monitoring of peak cough expiratory flow, oxygen saturation and respiratory discomfort seems difficult to obtain because of poor adherence to measures; this protocol does not seem to add anything to current practice of advising on clinical derangements. Confirmatory larger studies are necessary.

      PubDate: 2014-02-02T17:19:15Z
      DOI: 10.1016/j.rppneu.2013.11.003
  • Place of death in patients with amyotrophic lateral sclerosis

    • Authors: J. Escarrabill; A. Vianello; E. Farrero; N. Ambrosino; J. Martínez Llorens; M. Vitacca
      Pages: 188 - 193
      Abstract: Publication date: Available online 29 April 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): J. Escarrabill , A. Vianello , E. Farrero , N. Ambrosino , J. Martínez Llorens , M. Vitacca
      Amyotrophic lateral sclerosis (ALS) is a degenerative neurological disorder that affects motor neurons. Involvement of respiratory muscles causes the failure of the ventilator pump with more or less significant bulbar troubles. ALS course is highly variable but, in most cases, this disease entails a very significant burden for patients and caregivers, especially in the end-of-life period. In order to analyze the characteristics of ALS patients who die at home (DH) and in hospital (DHosp) and to study the variability of clinical practice, a retrospective medical records analysis was performed (n =77 from five hospitals). Variables: time elapsed since the onset of symptoms and the beginning of ventilation, characteristics of ventilation (device, mask and hours/day), and support devices and procedures. Results In all, 14% of patients were ventilated by tracheotomy. From the analysis, 57% of patients were of DH. Mean time since the onset of symptoms was 35.93±25.89 months, significantly shorter in patients who DHosp (29.28±19.69 months) than DH (41.12±29.04) (p =0.044). The percentage of patients with facial ventilation is higher in DHosp (11.4% vs 39.4%, p <0.005). DH or not is related to a set of elements in which health resources, physician attitudes and support resources in the community play a role in the decision-making process. There is great variability between countries and between hospitals in the same country. Given the variability of circumstances in each territory, the place of death in ALS might not be the most important element; more important are the conditions under which the process unfolds.

      PubDate: 2014-04-30T16:15:13Z
      DOI: 10.1016/j.rppneu.2014.03.001
  • Symptoms, location and prognosis of pulmonary embolism

    • Authors: M.T. García-Sanz; C. Pena-Álvarez; P. López-Landeiro; A. Bermo-Domínguez; T. Fontúrbel; F.J. González-Barcala
      Pages: 194 - 199
      Abstract: Publication date: Available online 22 January 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): M.T. García-Sanz , C. Pena-Álvarez , P. López-Landeiro , A. Bermo-Domínguez , T. Fontúrbel , F.J. González-Barcala
      Background and objective Pulmonary embolism (PE) is a common disease with variable symptoms and high overall mortality. The clinical relevance of the extent of PE is still debatable, and the role of anticoagulation in patients with subsegmental involvement has been contested. Our objective is to describe the clinical details of patients with PE in our hospital and to analyze their prognosis based on the extent of the disease. Materials and methods Retrospective study of 313 patients diagnosed with PE by chest computed tomography (CT) scan at the Hospital Complex of Pontevedra in Spain for six years. Predictors of mortality were determined by multivariate analysis. Results Women accounted for 56% of patients, and patient median age was 70 years (interquartile range 53–78 years). Subsegmental PE accounted for 7% of all cases; these patients were younger and had lower comorbidity; they reported chest pain more often, performed better in blood gas analysis and none of them had proximal deep vein thrombosis (DVT). Patients with subsegmental PE had a higher survival rate. Factors independently associated with mortality were cancer diagnosis and higher comorbidity. Conclusions Patients with subsegmental PE clinically differ from those with more proximal PE. Underlying diseases have more influence on the prognosis than the extent of the disease.

      PubDate: 2014-01-23T17:10:23Z
      DOI: 10.1016/j.rppneu.2013.09.006
  • ERCC1 expression correlated with EGFR and clinicopathological variables in
           patients with non‐small cell lung cancer. An immunocytochemical study on
           fine‐needle aspiration biopsies samples

    • Authors: A. Kalogeraki; I. Karvela-Kalogeraki; D. Tamiolakis; P. Petraki; Z. Saridaki; M. Tzardi
      Pages: 200 - 207
      Abstract: Publication date: Available online 6 February 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): A. Kalogeraki , I. Karvela‐Kalogeraki , D. Tamiolakis , P. Petraki , Z. Saridaki , M. Tzardi
      Purpose Expression of ERCC1 has not been well described in fine‐needle aspiration biopsies (FNABs) in patients with non‐small cell lung cancer (NSCLC). We investigated the expression of ERCC1 in correlation with EGFR expression and clinicopathological factors in patients with NSCLC in order to determine if these play a role in the prognosis of the disease. Methods We studied 45 patients, 34 with adenocarcinoma and 11 with squamous cell carcinoma. Of these 45 patients, 35 were males and 10 females, aged between 45 and 83 years, 30 smokers and 15 non‐smokers. Eighteen (18) tumors were of stage I, twelve (12) stage II and fifteen (15) stage III. To investigate the expression of ERCC1 and EGFR (scores 0, 1, 2, 3), immunocytochemistry was performed on air dried specimens (FNABs) using monoclonal antibodies by alkaline‐phosphatase (APAAP) method. Results ERCC1 expression was detected in tumors from 27 patients (60%) and EGFR in 10 patients (22.2%). ERCC1 was expressed more frequently in males (65.7%) in patients >65 years old (64%), in smokers (66.7%) and in stage I (66.7%). Negative ERCC1 expression was significantly associated with the presence of EGFR. EGFR was expressed only in adenocarcinomas and more frequently in women (70%) and non smokers (53.3%). Conclusions ERCC1 expression was identified as positive (scores 2+ and 3+) in the majority of NSCLCs and seems to be an independent prognostic marker of longer survival. In addition EGFR expression was positive (scores 2+ and 3+) in the minority of NSCLCs and only in adenocarcinomas, more frequently in ERCC1‐negative (scores 0 and 1+) tumors, suggesting that it is not an independent prognostic marker for the outcome of the patients suffering from NSCLC.

      PubDate: 2014-02-12T17:35:49Z
      DOI: 10.1016/j.rppnen.2014.06.003
  • Prevalence of asthma and rhinitis symptoms among children living in
           Coimbra, Portugal

    • Authors: M. Muc; A. Mota-Pinto; C. Padez
      Pages: 208 - 210
      Abstract: Publication date: July–August 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 4
      Author(s): M. Muc , A. Mota-Pinto , C. Padez

      PubDate: 2014-07-27T14:29:43Z
      DOI: 10.1016/j.rppnen.2013.08.003
  • Open circuit mouthpiece ventilation: Concise clinical review

    • Authors: G. Garuti; A. Nicolini; B. Grecchi; M. Lusuardi; J.C. Winck; J.R. Bach
      Pages: 211 - 218
      Abstract: Publication date: Available online 17 May 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): G. Garuti , A. Nicolini , B. Grecchi , M. Lusuardi , J.C. Winck , J.R. Bach
      In 2013 new “mouthpiece ventilation” modes are being introduced to commercially available portable ventilators. Despite this, there is little knowledge of how to use noninvasive intermittent positive pressure ventilation (NIV) as opposed to bi-level positive airway pressure (PAP) and both have almost exclusively been reported to have been used via nasal or oro-nasal interfaces rather than via a simple mouthpiece. Non-invasive ventilation is often reported as failing because of airway secretion encumbrance, because of hypercapnia due to inadequate bi-level PAP settings, or poor interface tolerance. The latter can be caused by factors such as excessive pressure on the face from poor fit, excessive oral air leak, anxiety, claustrophobia, and patient-ventilator dys-synchrony. Thus, the interface plays a crucial role in tolerance and effectiveness. Interfaces that cover the nose and/or nose and mouth (oro-nasal) are the most commonly used but are more likely to cause skin breakdown and claustrophobia. Most associated drawbacks can be avoided by using mouthpiece NIV. Open-circuit mouthpiece NIV is being used by large populations in some centers for daytime ventilatory support and complements nocturnal NIV via “mask” interfaces for nocturnal ventilatory support. Mouthpiece NIV is also being used for sleep with the mouthpiece fixed in place by a lip-covering flange. Small 15 and 22mm angled mouthpieces and straw-type mouthpieces are the most commonly used. NIV via mouthpiece is being used as an effective alternative to ventilatory support via tracheostomy tube (TMV) and is associated with a reduced risk of pneumonias and other respiratory complications. Its use facilitates “air-stacking” to improve cough, speech, and pulmonary compliance, all of which better maintain quality of life for patients with neuromuscular diseases (NMDs) than the invasive alternatives. Considering these benefits and the new availability of mouthpiece ventilator modes, wider knowledge of this technique is now warranted. This review highlights the indications, techniques, advantages and disadvantages of mouthpiece NIV.

      PubDate: 2014-05-25T21:19:58Z
      DOI: 10.1016/j.rppnen.2014.06.007
  • Chronic granulomatous disease associated with common variable
           immunodeficiency – 2 clinical cases

    • Authors: C. Pacheco; A. Morais; R. Rolo; L. Ferreira; R. Nabiço; J. Cunha
      Pages: 219 - 222
      Abstract: Publication date: Available online 23 January 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): C. Pacheco , A. Morais , R. Rolo , L. Ferreira , R. Nabiço , J. Cunha
      Introduction Chronic granulomatous disease associated with common variable immunodeficiency (GD-CVID), although well documented, is rare. Granulomatous lesions can affect several organs and are histologically indistinguishable from sarcoidosis. Clinical cases Case 1: A 39-year-old male patient with CVID, asymptomatic although with thrombocytopenia and mediastinal-hilar adenopathies. GD-CVID was diagnosed by bone marrow biopsy. Progressive clinical and radiological improvement was obtained with corticotherapy. Case 2: A 38-year-old male patient with CVID, suffered from asthenia, anorexia, myalgia, lower limbs edemas, and dry cough. He had mediastinal and bilateral hilar adenopathies within which biopsy revealed non-necrotizing granulomatous infiltrate. A spontaneous resolution was detected after 9 months of evolution. Conclusion GD-CVID is rare and can mimetize other pathologies, namely, sarcoidosis; it should therefore be publicized and discussed so that it becomes a general clinical knowledge.

      PubDate: 2014-01-28T13:33:46Z
      DOI: 10.1016/j.rppneu.2013.09.005
  • Unusual late lung metastasis from leiomyosarcoma of the uterus

    • Authors: A. Carreiro; L. Frias; A. Miguel; M. Rocha; V. Carneiro; C. Pavão
      Pages: 223 - 224
      Abstract: Publication date: Available online 27 April 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): A. Carreiro , L. Frias , A. Miguel , M. Rocha , V. Carneiro , C. Pavão

      PubDate: 2014-04-30T16:15:13Z
      DOI: 10.1016/j.rppnen.2014.06.005
  • Singing in chronic obstructive pulmonary disease patients: A pilot study
           in Portugal

    • Authors: Cecília Pacheco; Ana Costa; Joana Amado; Paula Almeida
      Pages: 225 - 228
      Abstract: Publication date: Available online 30 April 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): Cecília Pacheco , Ana Costa , Joana Amado , Paula Almeida

      PubDate: 2014-05-05T16:22:23Z
      DOI: 10.1016/j.rppnen.2014.06.006
  • Pleural adenosine deaminase in the diagnostic workup of tuberculous
           pleural effusion

    • Authors: R. Reis; A.S. Costa; B. Conde
      Pages: 228 - 229
      Abstract: Publication date: Available online 10 May 2014
      Source:Revista Portuguesa de Pneumologia
      Author(s): R. Reis , A.S. Costa , B. Conde

      PubDate: 2014-05-15T11:28:06Z
      DOI: 10.1016/j.rppnen.2014.03.012
  • EBUS in pulmonary sarcoidosis: What to expect?

    • Authors: I. Neves; M. Sucena; A. Magalhães; G. Fernandes
      Pages: 229 - 231
      Abstract: Publication date: July–August 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 4
      Author(s): I. Neves , M. Sucena , A. Magalhães , G. Fernandes

      PubDate: 2014-07-27T14:29:43Z
      DOI: 10.1016/j.rppnen.2014.04.003
  • Portuguese Journal of Pulmonology as a journal open to a variety of
           respiratory research

    • Authors: Morais
      Abstract: Publication date: November–December 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 6
      Author(s): A. Morais

      PubDate: 2014-12-13T17:19:00Z
  • Impact factor 0.85 – The ultimate goal or the next step forward?

    • Authors: Morais
      Abstract: Publication date: September–October 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 5
      Author(s): A. Morais

      PubDate: 2014-09-05T11:20:37Z
  • What is the clinical significance of isolated subsegmental pulmonary

    • Authors: M.A.
      Abstract: Publication date: July–August 2014
      Source:Revista Portuguesa de Pneumologia, Volume 20, Issue 4
      Author(s): M.A. Gómez-Sánchez

      PubDate: 2014-07-27T14:29:43Z
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