Subjects -> MEDICAL SCIENCES (Total: 8690 journals)
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RESPIRATORY DISEASES (105 journals)                     

Showing 1 - 105 of 105 Journals sorted alphabetically
Advances in Respiratory Medicine     Open Access   (Followers: 7)
Advances in Thoracic Diseases     Open Access   (Followers: 2)
American Journal of Respiratory and Critical Care Medicine     Full-text available via subscription   (Followers: 273)
American Journal of Respiratory Cell and Molecular Biology     Full-text available via subscription   (Followers: 22)
American Review of Respiratory Disease     Full-text available via subscription   (Followers: 4)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1)
Annals of the American Thoracic Society     Full-text available via subscription   (Followers: 18)
Annals of Thoracic Medicine     Open Access   (Followers: 6)
Archives of Pulmonology and Respiratory Care     Open Access   (Followers: 2)
Archivos de Bronconeumología     Full-text available via subscription  
Archivos de Bronconeumología (English Edition)     Full-text available via subscription   (Followers: 1)
Asthma Research and Practice     Open Access   (Followers: 2)
BMC Pulmonary Medicine     Open Access   (Followers: 7)
BMJ Open Respiratory Research     Open Access   (Followers: 8)
Breathe     Open Access   (Followers: 7)
Canadian Journal of Respiratory Therapy     Full-text available via subscription   (Followers: 3)
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine     Hybrid Journal   (Followers: 1)
Canadian Respiratory Journal     Open Access   (Followers: 3)
Case Reports in Pulmonology     Open Access   (Followers: 3)
Chest     Full-text available via subscription   (Followers: 109)
Chest Disease Reports     Open Access   (Followers: 2)
Chronic Respiratory Disease     Hybrid Journal   (Followers: 9)
Clinical Lung Cancer     Hybrid Journal   (Followers: 6)
Clinical Medicine Insights : Circulatory, Respiratory and Pulmonary Medicine     Open Access   (Followers: 3)
Clinical Pulmonary Medicine     Hybrid Journal   (Followers: 3)
COPD Research and Practice     Open Access   (Followers: 1)
COPD: Journal of Chronic Obstructive Pulmonary Disease     Hybrid Journal   (Followers: 17)
Current Opinion in Pulmonary Medicine     Hybrid Journal   (Followers: 10)
Current Pulmonology Reports     Hybrid Journal  
Current Research in Tuberculosis     Open Access   (Followers: 3)
Current Respiratory Care Reports     Hybrid Journal   (Followers: 2)
Current Respiratory Medicine Reviews     Hybrid Journal   (Followers: 5)
Der Pneumologe     Hybrid Journal   (Followers: 1)
Egyptian Journal of Chest Diseases and Tuberculosis     Open Access   (Followers: 3)
ERJ Open Research     Open Access   (Followers: 5)
Eurasian Journal of Pulmonology     Open Access  
European Clinical Respiratory Journal     Open Access   (Followers: 4)
European Respiratory Journal     Full-text available via subscription   (Followers: 42)
European Respiratory Review     Open Access   (Followers: 10)
Experimental Lung Research     Hybrid Journal   (Followers: 1)
Expert Review of Respiratory Medicine     Hybrid Journal   (Followers: 5)
Heart & Lung: The Journal of Acute and Critical Care     Hybrid Journal   (Followers: 14)
Heart, Lung and Circulation     Full-text available via subscription   (Followers: 9)
Indian Journal of Respiratory Care     Open Access   (Followers: 3)
Indian Journal of Tuberculosis     Full-text available via subscription  
Influenza and Other Respiratory Viruses     Open Access   (Followers: 3)
International Journal of Chronic Obstructive Pulmonary Disease     Open Access   (Followers: 3)
Journal of Association of Chest Physicians     Open Access   (Followers: 2)
Journal of Asthma     Hybrid Journal   (Followers: 5)
Journal of Asthma Allergy Educators     Hybrid Journal   (Followers: 5)
Journal of Bronchology & Interventional Pulmonology     Hybrid Journal   (Followers: 5)
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases     Open Access  
Journal of Heart and Lung Transplantation     Hybrid Journal   (Followers: 12)
Journal of Respiratory Medicine     Open Access   (Followers: 5)
Journal of Respiratory Research     Open Access   (Followers: 3)
Journal of Tuberculosis Research     Open Access   (Followers: 1)
Jurnal Respirasi     Open Access  
Karger Kompass Pneumologie     Full-text available via subscription   (Followers: 1)
Kindheit und Entwicklung     Hybrid Journal  
Lung     Hybrid Journal   (Followers: 3)
Lung Cancer     Hybrid Journal   (Followers: 15)
Lung Cancer International     Open Access   (Followers: 2)
Lung Cancer: Targets and Therapy     Open Access   (Followers: 3)
Lung India     Open Access   (Followers: 1)
Multidisciplinary Respiratory Medicine     Open Access   (Followers: 4)
npj Primary Care Respiratory Medicine     Open Access   (Followers: 2)
Open Journal of Respiratory Diseases     Open Access   (Followers: 2)
Open Respiratory Medicine Journal     Open Access   (Followers: 2)
Paediatric Respiratory Reviews     Hybrid Journal   (Followers: 11)
Pediatric Quality & Safety     Open Access  
Pediatric Respirology and Critical Care Medicine     Open Access   (Followers: 1)
Pulmonary Circulation     Open Access   (Followers: 4)
Pulmonary Medicine     Open Access   (Followers: 3)
Pulmonary Pharmacology & Therapeutics     Hybrid Journal   (Followers: 2)
Pulmonary Therapy     Open Access   (Followers: 2)
Pulmonology and Respiratory Research     Open Access   (Followers: 2)
Respiratory Care     Full-text available via subscription   (Followers: 12)
Respiratory Investigation     Full-text available via subscription   (Followers: 1)
Respiratory Medicine     Hybrid Journal   (Followers: 19)
Respiratory Medicine : X     Open Access  
Respiratory Medicine Case Reports     Open Access  
Respiratory Medicine CME     Hybrid Journal  
Respiratory Medicine Extra     Full-text available via subscription   (Followers: 1)
Respiratory Physiology & Neurobiology     Hybrid Journal   (Followers: 4)
Respiratory Research     Open Access   (Followers: 1)
Respirology     Hybrid Journal   (Followers: 5)
Respirology Case Reports     Open Access  
Revista Americana de Medicina Respiratoria     Open Access  
Revista Chilena de Enfermedades Respiratorias     Open Access  
Revista Inspirar     Open Access  
Revista ORL     Open Access  
Revista Portuguesa de Pneumologia     Open Access  
Sarcoidosis Vasculitis and Diffuse Lung Disese     Full-text available via subscription   (Followers: 3)
Seminars in Respiratory and Critical Care Medicine     Hybrid Journal   (Followers: 14)
Sleep Medicine Reviews     Hybrid Journal   (Followers: 18)
The Clinical Respiratory Journal     Hybrid Journal   (Followers: 3)
The International Journal of Tuberculosis and Lung Disease     Full-text available via subscription   (Followers: 9)
The Lancet Respiratory Medicine     Full-text available via subscription   (Followers: 38)
Therapeutic Advances in Chronic Disease     Open Access   (Followers: 8)
Therapeutic Advances in Respiratory Disease     Open Access   (Followers: 1)
Thorax     Hybrid Journal   (Followers: 39)
Translational Respiratory Medicine     Open Access   (Followers: 1)
Tuberculosis     Hybrid Journal   (Followers: 12)
Tuberculosis Research and Treatment     Open Access   (Followers: 3)
Пульмонология     Full-text available via subscription  

           

Similar Journals
Journal Cover
Thorax
Journal Prestige (SJR): 3.381
Citation Impact (citeScore): 4
Number of Followers: 39  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0040-6376 - ISSN (Online) 1468-3296
Published by BMJ Publishing Group Homepage  [68 journals]
  • Highlights from this issue
    • Authors: The Triumvirate
      Abstract: Line of duty... The police procedural drama ‘Line of Duty’ stars Nottingham girl Vicky McClure, as Detective Sergeant Kate Fleming. It emphasises the responsibilities of police officers in discharging their duties in a fair and even handed fashion and the gruesome consequences if they fail to do so. The ‘line of duty’ for primary care doctors, evaluating infants with suspected acute bronchiolitis, involves: using a guideline; measuring oxygen saturations; providing written guidance; and not prescribing drugs that don’t work (such as antibiotics). In this month’s journal Carande and colleagues describe how adherence to each of these recommendations has improved since the NICE guidelines on bronchiolitis were published (see page 674). Furthermore 35% of general practitioners had read the guideline and 25% changed their practice since guideline publication. DS Fleming would approve! The chain of evidence... The importance of an unbroken chain of evidence in forensic investigations...
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2018-212106
      Issue No: Vol. 73, No. 7 (2018)
       
  • Implementation science takes baby steps in infants with bronchiolitis
    • Authors: Cunningham, S; Pinnock, H.
      Pages: 599 - 600
      Abstract: Bronchiolitis, the annual winter endemic of acute viral lower respiratory tract illness in infants, is challenging for hospitals with overfull paediatric wards, for general practitioners worried about not spotting the infant at risk and for sleep-deprived parents looking after a sick child. The National Institute for Health and Care Excellence (NICE) Bronchiolitis guideline, published in 2015,1 highlights ‘red flags’ and lists ineffective treatments which ‘should not be used’, citing abundant clinical trials. In this journal, Carande and colleagues2 gauge the effect of the guideline publication on management in general practice. There were some shifts towards better practice in the (self-selected) general practitioner (GP) respondents, though improvement was incremental rather than transformational, as is common to new guidelines.3 Nearly three-quarters of respondents routinely used oximetry for the assessment of a child with acute bronchiolitis. Measuring oxygen saturation with an age-appropriate device has been widely promoted as...
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-211455
      Issue No: Vol. 73, No. 7 (2018)
       
  • Patients, caregivers and health system costs of home ventilation
    • Authors: Murphy, P. B; Douiri, A.
      Pages: 601 - 602
      Abstract: Long-term ventilation has been a successful part of the management of chronic respiratory failure since the use of the iron lungs was introduced during the polio epidemics in the 1930s and 1940s. The transition from hospital-based therapy to genuine home ventilation was pioneered by a number of physicians and patients including Robert Cavendish whose story was dramatised in the recent biopic ‘Breathe’. Robert Cavendish used his financial backing and engineering contacts to develop the first wheelchair mounted ventilator marking a watershed in the management of ventilator-dependent patients; empowering patients with chronic respiratory failure to live independent of a healthcare environment. Improvements in technology, for example, positive pressure ventilation, have facilitated the move from hospital to community support for complex respiratory patients; however, this comes at a cost to the patient, caregivers and the health system. The cost to the health system is rising as the number of patients’ requiring...
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2018-211659
      Issue No: Vol. 73, No. 7 (2018)
       
  • Cardiopulmonary rehabilitation for obese sleep-disordered breathing: a new
           treatment frontier'
    • Authors: Phillips, C. L; Cayanan, E. A, Hoyos, C. M.
      Pages: 603 - 604
      Abstract: The health benefits of routine exercise in otherwise healthy people, including in those who are obese, are well proven.1 Exercise improves cardiorespiratory fitness and improves blood supply to the musculature to enhance oxidative metabolism and overall efficiency of energy expenditure. There is also evidence showing the benefits of exercise might extend to people with debilitating conditions including congestive heart failure (CHF),2 COPD3 and more recently, obesity hypoventilation syndrome (OHS).4 In these populations, exercise training as part of a rehabilitation programme has been shown to improve exercise and functional capacity as well as overall quality of life. However, there are inherent (disease-specific) physiological limitations that pose significant barriers to full engagement in exercise training in people with chronic illness. For example, in the setting of pulmonary rehabilitation in COPD, exercise-induced dynamic hyperinflation increases the work of breathing, resulting in severe dyspnoea and a...
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2018-211607
      Issue No: Vol. 73, No. 7 (2018)
       
  • Gene expression signature of the ageing lung: breathing new life into COPD
    • Authors: Booth, S; Hackett, T.-L.
      Pages: 605 - 606
      Abstract: Due to consistently low birth rates and a higher life expectancy, countries within the European Union are transitioning to a much older population structure.1 The average number of older persons in the total population will increase significantly in the coming decade, as a large proportion of the post-war, baby-boom generation will reach retirement. Compared with generations prior, the ‘baby boomers’ were the most physically fit generation; however, they also grew up when smoking rates and exposure to secondhand smoke were at their peak.2 Tobacco use is a risk factor for six of the eight leading causes of death in the world including respiratory and cardiovascular diseases, stroke and cancer.2 Of these diseases, chronic obstructive pulmonary disease (COPD) is a major growing cause of morbidity and mortality3 with smoking and secondhand smoke exposure being the most important causative factors of the disease.
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-211173
      Issue No: Vol. 73, No. 7 (2018)
       
  • BTS guidelines for the initial outpatient management of pulmonary
           embolism: theres no place like home
    • Authors: Howard; L. S.
      Pages: 607 - 608
      Abstract: This article provides an overview of the highlights and key points of the new BTS guideline for the initial outpatient management of pulmonary embolism.
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2018-211646
      Issue No: Vol. 73, No. 7 (2018)
       
  • Lung tissue gene-expression signature for the ageing lung in COPD
    • Authors: de Vries, M; Faiz, A, Woldhuis, R. R, Postma, D. S, de Jong, T. V, Sin, D. D, Bosse, Y, Nickle, D. C, Guryev, V, Timens, W, van den Berge, M, Brandsma, C.-A.
      Pages: 609 - 617
      Abstract: IntroductionCOPD is a chronic, progressive, inflammatory disease of the lungs and the third leading cause of death worldwide. The current knowledge of the pathophysiology of COPD is limited and novel insights in underlying disease mechanisms are urgently needed. Since there are clear parallels between ageing and COPD, we investigated genes underlying lung ageing in general and abnormal lung ageing in COPD.MethodsWhole genome mRNA profiling was performed on lung tissue samples (n=1197) and differential gene expression with increasing age was analysed using an adjusted linear regression model. Subsequent pathway analysis was performed using GeneNetwork and the gene-expression signature was compared with lung ageing in the Genotype-Tissue Expression (GTEx) project. In a subset of patients with COPD (n=311) and non-COPD controls (n=270), we performed an interaction analysis between age and COPD to identify genes differentially expressed with age in COPD compared with controls, followed by gene set enrichment pathway analysis.ResultsWe identified a strong gene-expression signature for lung ageing with 3509 differentially expressed genes, of which 33.5% were found nominal significant in the GTEx project. Interestingly, we found EDA2R as a strong candidate gene for lung ageing. The age*COPD interaction analysis revealed 69 genes significantly differentially expressed with age between COPD and controls.ConclusionsOur study indicates that processes related to lung development, cell-cell contacts, calcium signalling and immune responses are involved in lung ageing in general. Pathways related to extracellular matrix, mammalian target of rapamycin signalling, splicing of introns and exons and the ribosome complex are proposed to be involved in abnormal lung ageing in COPD.
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-210074
      Issue No: Vol. 73, No. 7 (2018)
       
  • Late mortality after acute hypoxic respiratory failure
    • Authors: Prescott, H. C; Sjoding, M. W, Langa, K. M, Iwashyna, T. J, McAuley, D. F.
      Pages: 618 - 625
      Abstract: BackgroundAcute hypoxic respiratory failure (AHRF) is associated with significant acute mortality. It is unclear whether later mortality is predominantly driven by pre-existing comorbid disease, the acute inciting event or is the result of AHRF itself.MethodsObservational cohort study of elderly US Health and Retirement Study (HRS) participants in fee-for-service Medicare (1998–2012). Patients hospitalised with AHRF were matched 1:1 to otherwise similar adults who were not currently hospitalised and separately to patients hospitalised with acute inciting events (pneumonia, non-pulmonary infection, aspiration, trauma, pancreatitis) that may result in AHRF, here termed at-risk hospitalisations. The primary outcome was late mortality—death in the 31 days to 2 years following hospital admission.ResultsAmong 15 075 HRS participants, we identified 1268 AHRF and 13 117 at-risk hospitalisations. AHRF hospitalisations were matched to 1157 non-hospitalised adults and 1017 at-risk hospitalisations. Among patients who survived at least 30 days, AHRF was associated with a 24.4% (95%CI 19.9% to 28.9%, p
      Keywords: Open access, Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-210109
      Issue No: Vol. 73, No. 7 (2018)
       
  • Lung cancer risk to personalise annual and biennial follow-up computed
           tomography screening
    • Authors: Schreuder, A; Schaefer-Prokop, C. M, Scholten, E. T, Jacobs, C, Prokop, M, van Ginneken, B.
      Pages: 626 - 633
      Abstract: BackgroundAll lung cancer CT screening trials used fixed follow-up intervals, which may not be optimal. We developed new lung cancer risk models for personalising screening intervals to 1 year or 2 years, and compared these with existing models.MethodsWe included participants in the CT arm of the National Lung Screening Trial (2002–2010) who underwent a baseline scan and a first annual follow-up scan and were not diagnosed with lung cancer in the first year. True and false positives and the area under the curve of each model were calculated. Internal validation was performed using bootstrapping.ResultsData from 24 542 participants were included in the analysis. The accuracy was 0.785, 0.693, 0.697, 0.666 and 0.727 for the polynomial, patient characteristics, diameter, Patz and PanCan models, respectively. Of the 24 542 participants included, 174 (0.71%) were diagnosed with lung cancer between the first and the second annual follow-ups. Using the polynomial model, 2558 (10.4%, 95% CI 10.0% to 10.8%), 7544 (30.7%, 30.2% to 31.3%), 10 947 (44.6%, 44.0% to 45.2%), 16 710 (68.1%, 67.5% to 68.7%) and 20 023 (81.6%, 81.1% to 92.1%) of the 24 368 participants who did not develop lung cancer in the year following the first follow-up screening round could have safely skipped it, at the expense of delayed diagnosis of 0 (0.0%, 0.0% to 2.7%), 8 (4.6%, 2.2% to 9.2%), 17 (9.8%, 6.0% to 15.4%), 44 (25.3%, 19.2% to 32.5%) and 70 (40.2%, 33.0% to 47.9%) of the 174 lung cancers, respectively.ConclusionsThe polynomial model, using both patient characteristics and baseline scan morphology, was significantly superior in assigning participants to 1-year or 2-year screening intervals. Implementing personalised follow-up intervals would enable hundreds of participants to skip a screening round per lung cancer diagnosis delayed.
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-211107
      Issue No: Vol. 73, No. 7 (2018)
       
  • Ventilatory support or respiratory muscle training as adjuncts to exercise
           in obese CPAP-treated patients with obstructive sleep apnoea: a randomised
           controlled trial
    • Authors: Vivodtzev, I; Tamisier, R, Croteau, M, Borel, J.-C, Grangier, A, Wuyam, B, Levy, P, Minville, C, Series, F, Maltais, F, Pepin, J.-L.
      Pages: 634 - 643
      Abstract: BackgroundObstructive sleep apnoea (OSA) and obesity are interdependent chronic diseases sharing reduced exercise tolerance and high cardiovascular risk.InterventionA 3-month intervention with innovative training modalities would further improve functional capacity and cardiovascular health than usual cycle exercise training in already continuous positive airway pressure (CPAP)-treated obese patients with OSA.MethodsFifty three patients (35
      Keywords: Editor's choice, Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-211152
      Issue No: Vol. 73, No. 7 (2018)
       
  • Healthcare utilisation and costs of home mechanical ventilation
    • Authors: Nonoyama, M. L; McKim, D. A, Road, J, Guerriere, D, Coyte, P. C, Wasilewski, M, Avendano, M, Katz, S. L, Amin, R, Goldstein, R, Zagorski, B, Rose, L.
      Pages: 644 - 651
      Abstract: BackgroundIndividuals using home mechanical ventilation (HMV) frequently choose to live at home for quality of life, despite financial burden. Previous studies of healthcare utilisation and costs do not consider public and private expenditures, including caregiver time.ObjectivesTo determine public and private healthcare utilisation and costs for HMV users living at home in two Canadian provinces, and examine factors associated with higher costs.MethodsLongitudinal, prospective observational cost analysis study (April 2012 to August 2015) collecting data on public and private (out-of-pocket, third-party insurance, caregiving) costs every 2 weeks for 6 months using the Ambulatory and Home Care Record. Functional Independence Measure (FIM) was used at baseline and study completion. Regression models examined variables associated with total monthly costs selected a priori using Andersen and Newman’s framework for healthcare utilisation, relevant literature, and clinical expertise. Data are reported in 2015 Canadian dollars ($C1=US$0.78=0.51=0.71).ResultsWe enrolled 134 HMV users; 95 with family caregivers. Overall median (IQR) monthly healthcare cost was $5275 ($2291–$10 181) with $2410 (58%) publicly funded; $1609 (39%) family caregiving; and $141 (3%) out-of-pocket (
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-211138
      Issue No: Vol. 73, No. 7 (2018)
       
  • Stratification by interferon-{gamma} release assay level predicts risk of
           incident TB
    • Authors: Winje, B. A; White, R, Syre, H, Skutlaberg, D. H, Oftung, F, Mengshoel, A. T, Blix, H. S, Brantsaeter, A. B, Holter, E. K, Handal, N, Simonsen, G. S, Afset, J. E, Bakken Kran, A. M.
      Pages: 652 - 661
      Abstract: IntroductionTargeted testing and treatment of latent TB infection (LTBI) are priorities on the global health agenda, but LTBI management remains challenging. We aimed to evaluate the prognostic value of the QuantiFERON TB-Gold (QFT) test for incident TB, focusing on the interferon (IFN)- level, when applied in routine practice in a low TB incidence setting.MethodsIn this large population-based prospective cohort, we linked QFT results in Norway (1 January 2009–30 June 2014) with national registry data (Norwegian Surveillance System for Infectious Diseases, Norwegian Prescription Database, Norwegian Patient Registry and Statistics Norway) to assess the prognostic value of QFT for incident TB. Participants were followed until 30 June 2016. We used restricted cubic splines to model non-linear relationships between IFN- levels and TB, and applied these findings to a competing risk model.ResultsThe prospective analyses included 50 389 QFT results from 44 875 individuals, of whom 257 developed TB. Overall, 22% (n=9878) of QFT results were positive. TB risk increased with the IFN- level until a plateau level, above which further increase was not associated with additional prognostic information. The HRs for TB were 8.8 (95% CI 4.7 to 16.5), 19.2 (95% CI 11.6 to 31.6) and 31.3 (95% CI 19.8 to 49.5) times higher with IFN- levels of 0.35 to
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-211147
      Issue No: Vol. 73, No. 7 (2018)
       
  • Improving the global diagnosis and management of asthma in children
    • Authors: Lenney; W., Bush, A., Fitzgerald, D. A., Fletcher, M., Ostrem, A., Pedersen, S., Szefler, S. J., Zar, H. J., on behalf of the GSK Paediatric Project Advisory Board Committee
      Pages: 662 - 669
      Abstract: Asthma is the most common chronic condition in children worldwide. It affects daytime activities, sleep and school attendance and causes anxiety to parents, families and other carers. The quality of asthma diagnosis and management globally still needs substantial improvement. From infancy to the teenage years, there are age-specific challenges, including both underdiagnosis and overdiagnosis with stigma-related barriers to treatment in some cultures and in adolescents. Guidelines are increasingly evidence based, but their impact on improving outcomes has been negligible in many parts of the world, often due to lack of implementation. New thinking is needed to enable substantial improvements in outcomes. The disease varies globally and plans will need to differ for individual countries or places where region-specific barriers prevent optimal care. A wide selection of educational activities is needed, including community-targeted initiatives, to engage with families. The Paediatric Asthma Project Plan has been initiated to strengthen diagnosis and management of asthma. This encompasses a vision for the next 10–15 years, building on the knowledge and experience from previous educational projects. It will take into account the educational needs of patients, carers and healthcare professionals as well as the accessibility and affordability of medication, particularly in low and middle-income countries where the prevalence of asthma is rising more rapidly. This overview presents a first step for those involved in the diagnosis and management of childhood asthma to strengthen care for children globally.
      Keywords: Open access, Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2018-211626
      Issue No: Vol. 73, No. 7 (2018)
       
  • Do guidelines for treating chest disease in children use Cochrane Reviews
           effectively' A systematic review
    • Authors: Prayle, A. P; Cox, T, Smith, S. J, Rycroft-Malone, J, Thomas, K. S, Hughes, D. A, Smyth, A. R.
      Pages: 670 - 673
      Abstract: Cochrane Reviews summarise best evidence and should inform guidelines. We assessed the use of Cochrane Reviews in the UK guidelines for paediatric respiratory disease. We found 21 guidelines which made 1025 recommendations, of which 96 could be informed by a Cochrane Review. In 38/96 recommendations (40%), some or all of the relevant Cochrane Reviews were not cited. We linked recommendations to 140 Cochrane Reviews. In 37/140 (26%) cases, the guideline recommendation did not fully agree with the Cochrane Review. Guideline developers may fail to use Cochrane Reviews or may make recommendations which are not in line with best evidence.
      Keywords: Open access
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2016-208790
      Issue No: Vol. 73, No. 7 (2018)
       
  • Change in viral bronchiolitis management in primary care in the UK after
           the publication of NICE guideline
    • Authors: Carande, E. J; Cheung, C. R, Pollard, A. J, Drysdale, S. B.
      Pages: 674 - 676
      Abstract: The aim of this study was to investigate changes in general practitioner (GP) management before and after the publication of the National Institute for Health and Care Excellence bronchiolitis guideline. In March 2015 and May 2016, an electronic questionnaire was sent to GPs. It was completed by 1001 GPs in 2015 and 1009 in 2016. There were small but significant improvements in proportions of GPs using a guideline, measuring oxygen saturations and providing written guidance, and appropriate reductions in those prescribing medications. Thirty-five per cent had read the guideline and 25% changed their practice since guideline publication. There were modest but significant improvements in reported management by GPs after guideline publication.
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-211180
      Issue No: Vol. 73, No. 7 (2018)
       
  • Molecular epidemiology of Pseudomonas aeruginosa in an unsegregated
           bronchiectasis cohort sharing hospital facilities with a cystic fibrosis
           cohort
    • Authors: Mitchelmore, P. J; Randall, J, Bull, M. J, Moore, K. A, ONeill, P. A, Paszkiewicz, K, Mahenthiralingam, E, Scotton, C. J, Sheldon, C. D, Withers, N. J, Brown, A. R.
      Pages: 677 - 679
      Abstract: While Pseudomonas aeruginosa (PA) cross-infection is well documented among patients with cystic fibrosis (CF), the equivalent risk among patients with non-CF bronchiectasis (NCFB) is unclear, particularly those managed alongside patients with CF. We performed analysis of PA within a single centre that manages an unsegregated NCFB cohort alongside a segregated CF cohort. We found no evidence of cross-infection between the two cohorts or within the segregated CF cohort. However, within the unsegregated NCFB cohort, evidence of cross-infection was found between three (of 46) patients. While we do not presently advocate any change in the management of our NCFB cohort, longitudinal surveillance is clearly warranted.
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2016-209889
      Issue No: Vol. 73, No. 7 (2018)
       
  • Validity, responsiveness and minimum clinically important difference of
           the incremental shuttle walk in idiopathic pulmonary fibrosis: a
           prospective study
    • Authors: Nolan, C. M; Delogu, V, Maddocks, M, Patel, S, Barker, R. E, Jones, S. E, Kon, S. S. C, Maher, T. M, Cullinan, P, Man, W. D.-C.
      Pages: 680 - 682
      Abstract: The incremental shuttle walk (ISW) is well validated in COPD but limited psychometric data restrict its use in idiopathic pulmonary fibrosis (IPF). Study 1: 50 patients performed the ISW and 6 min walk test (6MWT). Study 2: 72 patients completed the ISW before and after pulmonary rehabilitation (PR). The ISW correlated strongly with 6MWT distance (r=0.81,p
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-210589
      Issue No: Vol. 73, No. 7 (2018)
       
  • Timing of onset of symptoms in people with idiopathic pulmonary fibrosis
    • Authors: Hewson, T; McKeever, T. M, Gibson, J. E, Navaratnam, V, Hubbard, R. B, Hutchinson, J. P.
      Pages: 683 - 685
      Abstract: Little is known about when symptoms of idiopathic pulmonary fibrosis first develop. We identified incident cases of idiopathic pulmonary fibrosis-clinical syndrome (IPF-CS) from a UK primary care database and assessed the frequency of consultations for common symptoms in the 5 years prior to diagnosis. 1671 cases were identified with 5 years of data prior to diagnosis. Breathlessness was the most common symptom, followed by cough. Cases were significantly more likely than controls to experience these symptoms (p
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-210177
      Issue No: Vol. 73, No. 7 (2018)
       
  • Case-based discussion from the neonatal intensive care unit: a case of an
           intentional oesophageal intubation
    • Authors: Jamieson, K; Boyd, S, Tan, S, Wong, D, James, P, Durward, A, Nyman, A.
      Pages: 686 - 688
      Abstract: Tracheal agenesis (TA) is a rare congenital defect consisting of complete or partial absence of the trachea below the larynx. Antenatal diagnosis is challenging, and most cases are detected in the postnatal period. Airway management of such cases, particularly in the absence of antenatal diagnosis, can be challenging. Various methods of management have been described but with limited success, and overall prognosis remains very poor. We present an unexpected case of TA, highlighting management issues and diagnostic methods.
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-210717
      Issue No: Vol. 73, No. 7 (2018)
       
  • Unexpected migration
    • Authors: Raghuram, G; Mukherjee, D, Pannu, K, Bhusari, S.
      Pages: 689 - 690
      Abstract: A 79-year-old man had presented to his general practitioner with a non-resolving pneumonia. He was treated with three courses of antibiotics after which a chest radiograph (figure 1) showed right lower zone opacity with an effusion raising concerns of underlying malignancy. He was referred urgently to the respiratory team via the suspected cancer pathway. A staging CT scan of chest and liver (figure 1) was requested. The staging CT chest and liver described a focal mass-like consolidation in the subpleural region of the right middle lobe and an ovoid well-circumscribed lesion within the epicentre of the consolidation demonstrating laminated patterns of calcification. The patient had undergone a complicated laparoscopic cholecystectomy 6 months prior to this presentation. A CT abdomen then had shown clear lung bases. The intrathoracic lesion seen on the staging CT was morphologically very similar to the gallstone identified on the abdominal CT...
      Keywords: Images in Thorax, Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-210866
      Issue No: Vol. 73, No. 7 (2018)
       
  • Dieulafoys disease with mediastinal arteriovenous malformation
    • Authors: Foo, A. Z. X; Hsu, A. A. L.
      Pages: 691 - 692
      Abstract: A 42-year-old, non-smoker man was hospitalised for newly diagnosed acute myeloid leukaemia and had an episode of haemoptysis of 200 mL fresh blood, complicated by transient hypotension. Patient was afebrile and his blood results were: haemoglobin 10.0 g/dL decreasing to 8.5 g/dL within 1 day of haemoptysis, total white cell counts 23x109/L, platelet counts 30x109/L, normal renal panel and coagulation profile. CT scan reported extensive tortuous mediastinal vessels (figure 1A). Flexible bronchoscopy under platelet transfusion revealed a small lesion in the right upper lobe (RUL) bronchus (figure 2). Upon contact of the bronchoscope tip with the lesion, brisk bleeding occurred (online ) which ceased with ice-cold saline wash. A diagnosis of Dieulafoy’s disease associated with mediastinal arteriovenous malformation (AVM) was made. CT angiogram followed by embolisation of major vessels feeding into RUL (figures 1B and 3) was performed. Embolisation was successful with the patient experiencing no further haemoptysis...
      Keywords: Images in Thorax, Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-211243
      Issue No: Vol. 73, No. 7 (2018)
       
  • Pulmonary melioidosis with laryngeal involvement: an unusual site of
           infection
    • Authors: Ng, C. L; Liu, X, Tan, N. J. H, Prasad, V. M. N, Lee, P.
      Pages: 693 - 694
      Abstract: A 42-year-old Malay man presented with cough productive of yellowish sputum, hoarseness and intermittent daily fever associated with chills and rigours for 3 weeks. Apart from previous pulmonary TB in 1994 for which treatment was complete, there were no other comorbidities. The patient was an active cigarette smoker of 20 pack-years, and worked as an outdoor project coordinator frequently in contact with soil during field surveys in gardens. Chest radiograph showed right perihilar consolidation (figure 1A). CT thorax showed mass-like consolidation of the right upper lobe with extensive mediastinal lymphadenopathy (figure 1B). White cell count was 8.8 (range 3.4–11.0x109/L) with neutrophilia 72.2%; blood, sputum and urine for bacterial cultures, as well as sputum for acid fast bacilli smears and TB PCR assay, were negative. Random blood sugar level was 23.0 mmol/L (range 4.0–7.8 mmol/L) and glycated haemoglobin level was 12.1%. Bronchoscopy showed mobile vocal folds, ulcers affecting the false...
      Keywords: Images in Thorax, Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2017-211046
      Issue No: Vol. 73, No. 7 (2018)
       
  • Whats hot that the other lot got
    • Authors: McDowell; G.
      Pages: 696 - 696
      Abstract: A role for remote monitoring and automated messaging to boost early CPAP use in OSA' Continuous positive airway pressure (CPAP) is the gold standard treatment for obstructive sleep apnoea (OSA) but adherence to treatment can be poor. Telemedicine can provide remote access to adherence data, patient education platforms and enhance follow-up care. This four-arm randomised trial (Hwang et al. Am J Respir Crit Care Med 2018;197:117–26) assessed the impact of two interventions, web-based OSA education (Tel-Ed) and CPAP telemonitoring with automated messaging (Tel-TM), alone or in combination (Tel-both) in patients requiring CPAP for OSA and compared their effects on CPAP adherence at 90 days to usual care. CPAP usage was evaluated in 556 patients. Usage at 90 days was significantly higher in both the Tel-TM and Tel-both compared with usual care (both P=0.0002). Odds of achieving target adherence (≥70% days with CPAP usage ≥4 hours; the level set for reimbursement in...
      Keywords: Thorax
      PubDate: 2018-06-13T05:05:05-07:00
      DOI: 10.1136/thoraxjnl-2018-212103
      Issue No: Vol. 73, No. 7 (2018)
       
 
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