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RESPIRATORY DISEASES (102 journals)                     

Showing 1 - 102 of 102 Journals sorted alphabetically
Advances in Respiratory Medicine     Open Access   (Followers: 7)
American Journal of Respiratory and Critical Care Medicine     Full-text available via subscription   (Followers: 257)
American Journal of Respiratory Cell and Molecular Biology     Full-text available via subscription   (Followers: 20)
American Review of Respiratory Disease     Full-text available via subscription   (Followers: 4)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1)
Annals of the American Thoracic Society     Full-text available via subscription   (Followers: 17)
Annals of Thoracic Medicine     Open Access   (Followers: 6)
Archivos de Bronconeumología     Full-text available via subscription  
Archivos de Bronconeumología (English Edition)     Full-text available via subscription   (Followers: 1)
Asthma Research and Practice     Open Access   (Followers: 1)
BMC Pulmonary Medicine     Open Access   (Followers: 5)
BMJ Open Respiratory Research     Open Access   (Followers: 6)
Breathe     Open Access   (Followers: 4)
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine     Hybrid Journal   (Followers: 1)
Canadian Respiratory Journal     Open Access   (Followers: 3)
Case Reports in Pulmonology     Open Access   (Followers: 3)
Chest     Full-text available via subscription   (Followers: 101)
Chest Disease Reports     Open Access   (Followers: 2)
Chronic Respiratory Disease     Hybrid Journal   (Followers: 9)
Clinical Lung Cancer     Hybrid Journal   (Followers: 6)
Clinical Medicine Insights : Circulatory, Respiratory and Pulmonary Medicine     Open Access   (Followers: 3)
Clinical Pulmonary Medicine     Hybrid Journal   (Followers: 2)
COPD Research and Practice     Open Access   (Followers: 1)
COPD: Journal of Chronic Obstructive Pulmonary Disease     Hybrid Journal   (Followers: 15)
Current Opinion in Pulmonary Medicine     Hybrid Journal   (Followers: 10)
Current Pulmonology Reports     Hybrid Journal  
Current Research in Tuberculosis     Open Access   (Followers: 3)
Current Respiratory Care Reports     Hybrid Journal   (Followers: 1)
Current Respiratory Medicine Reviews     Hybrid Journal   (Followers: 5)
Der Pneumologe     Hybrid Journal   (Followers: 1)
Egyptian Journal of Chest Diseases and Tuberculosis     Open Access   (Followers: 3)
ERJ Open Research     Open Access   (Followers: 3)
Eurasian Journal of Pulmonology     Open Access  
European Clinical Respiratory Journal     Open Access   (Followers: 3)
European Respiratory Journal     Full-text available via subscription   (Followers: 39)
European Respiratory Review     Open Access   (Followers: 7)
Experimental Lung Research     Hybrid Journal  
Expert Review of Respiratory Medicine     Hybrid Journal   (Followers: 5)
Heart & Lung: The Journal of Acute and Critical Care     Hybrid Journal   (Followers: 13)
Heart, Lung and Circulation     Full-text available via subscription   (Followers: 9)
Indian Journal of Respiratory Care     Open Access   (Followers: 3)
Indian Journal of Tuberculosis     Full-text available via subscription  
Influenza and Other Respiratory Viruses     Open Access   (Followers: 3)
International Journal of Chronic Obstructive Pulmonary Disease     Open Access   (Followers: 3)
Journal of Association of Chest Physicians     Open Access   (Followers: 2)
Journal of Asthma     Hybrid Journal   (Followers: 4)
Journal of Asthma Allergy Educators     Hybrid Journal   (Followers: 4)
Journal of Bronchology & Interventional Pulmonology     Hybrid Journal   (Followers: 4)
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases     Open Access  
Journal of Heart and Lung Transplantation     Hybrid Journal   (Followers: 12)
Journal of Respiratory Medicine     Open Access   (Followers: 4)
Journal of Respiratory Research     Open Access   (Followers: 1)
Journal of Tuberculosis Research     Open Access   (Followers: 1)
Jurnal Respirasi     Open Access  
Karger Kompass Pneumologie     Full-text available via subscription   (Followers: 1)
Kindheit und Entwicklung     Hybrid Journal  
Lung     Hybrid Journal   (Followers: 2)
Lung Cancer     Hybrid Journal   (Followers: 16)
Lung Cancer International     Open Access   (Followers: 2)
Lung Cancer: Targets and Therapy     Open Access   (Followers: 3)
Lung India     Open Access   (Followers: 1)
Multidisciplinary Respiratory Medicine     Open Access   (Followers: 4)
npj Primary Care Respiratory Medicine     Open Access   (Followers: 2)
Open Journal of Respiratory Diseases     Open Access   (Followers: 1)
Open Respiratory Medicine Journal     Open Access   (Followers: 1)
Paediatric Respiratory Reviews     Hybrid Journal   (Followers: 11)
Pediatric Quality & Safety     Open Access  
Pediatric Respirology and Critical Care Medicine     Open Access   (Followers: 1)
Pulmonary Circulation     Open Access   (Followers: 4)
Pulmonary Medicine     Open Access   (Followers: 2)
Pulmonary Pharmacology & Therapeutics     Hybrid Journal   (Followers: 2)
Pulmonary Therapy     Open Access   (Followers: 1)
Pulmonology and Respiratory Research     Open Access   (Followers: 1)
Respiratory Care     Full-text available via subscription   (Followers: 10)
Respiratory Investigation     Full-text available via subscription  
Respiratory Medicine     Hybrid Journal   (Followers: 18)
Respiratory Medicine : X     Open Access  
Respiratory Medicine Case Reports     Open Access  
Respiratory Medicine CME     Hybrid Journal  
Respiratory Medicine Extra     Full-text available via subscription   (Followers: 1)
Respiratory Physiology & Neurobiology     Hybrid Journal   (Followers: 4)
Respiratory Research     Open Access   (Followers: 1)
Respirology     Hybrid Journal   (Followers: 5)
Respirology Case Reports     Open Access  
Revista Americana de Medicina Respiratoria     Open Access  
Revista Chilena de Enfermedades Respiratorias     Open Access  
Revista Inspirar     Open Access  
Revista ORL     Open Access  
Revista Portuguesa de Pneumologia     Open Access  
Sarcoidosis Vasculitis and Diffuse Lung Disese     Full-text available via subscription   (Followers: 3)
Seminars in Respiratory and Critical Care Medicine     Hybrid Journal   (Followers: 14)
Sleep Medicine Reviews     Hybrid Journal   (Followers: 18)
The Clinical Respiratory Journal     Hybrid Journal   (Followers: 3)
The International Journal of Tuberculosis and Lung Disease     Full-text available via subscription   (Followers: 8)
The Lancet Respiratory Medicine     Full-text available via subscription   (Followers: 33)
Therapeutic Advances in Chronic Disease     Open Access   (Followers: 7)
Therapeutic Advances in Respiratory Disease     Open Access   (Followers: 1)
Thorax     Hybrid Journal   (Followers: 38)
Translational Respiratory Medicine     Open Access   (Followers: 1)
Tuberculosis     Hybrid Journal   (Followers: 12)
Tuberculosis Research and Treatment     Open Access   (Followers: 3)
Пульмонология     Full-text available via subscription  


Similar Journals
Journal Cover
Sleep Medicine Reviews
Journal Prestige (SJR): 3.376
Citation Impact (citeScore): 8
Number of Followers: 18  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1087-0792 - ISSN (Online) 1532-2955
Published by Elsevier Homepage  [3206 journals]
  • Reply to Zhang et al.: Downgrading recommendation level of prazosin for
           treating trauma-related nightmares: Should decision be based on a single
    • Abstract: Publication date: Available online 13 February 2020Source: Sleep Medicine ReviewsAuthor(s): Jaap Lancee, Dilan E. Yücel, Camille Souama, Arnold A.P. van Emmerik
  • Failure of fear extinction in insomnia: an evolutionary perspective
    • Abstract: Publication date: Available online 13 February 2020Source: Sleep Medicine ReviewsAuthor(s): Lampros Perogamvros, Anna Castelnovo, David Samson, Thien Thanh Dang-VuSummaryThe pathophysiology of insomnia remains poorly understood, yet emerging cross-disciplinary approaches integrating natural history, observational studies in traditional populations, gene-phenotype expression and experiments, are opening up new avenues to investigate the evolutionary origins of sleep disorders, with the potential to inform innovations in treatment. Previous authors have supported that acute insomnia is a normal biopsychosocial response to a perceived or real threat and may thus represent an adaptive response to stress. We further extend this hypothesis by claiming that insomnia reflects a fear-related evolutionary survival mechanism, which becomes persistent in some vulnerable individuals due to failure of the fear extinction function. Possible treatments targeting fear extinction are proposed, such as pharmacotherapy and emotion-based cognitive behavioral therapy.
  • Commentary on Barco et al. Interventions for sleep problems during
           pregnancy: a systematic review
    • Abstract: Publication date: Available online 13 February 2020Source: Sleep Medicine ReviewsAuthor(s): Qilin Tang, Siping Wang, Kai Zhang
  • Commentary on Yücel DE et al. Downgrading recommendation level of
           prazosin for treating trauma-related nightmares: Should decision be based
           on a single study'
    • Abstract: Publication date: Available online 13 February 2020Source: Sleep Medicine ReviewsAuthor(s): Ye Zhang, Rong Ren, Larry D. Sanford, Xiangdong Tang
  • Reply to Zhang et al: Commentary interventions for sleep problems during
    • Abstract: Publication date: Available online 13 February 2020Source: Sleep Medicine ReviewsAuthor(s): Valeria Bacaro, Fee Benz, Andrea Pappaccogli, Paola De Bartolo, Anna F. Johann, Laura Palagini, Caterina Lombardo, Bernd Feige, Dieter Riemann, Chiara Baglioni
  • Sleep’s impact on emotional recognition memory: A meta-analysis of
           whole-night, nap, and REM sleep effects
    • Abstract: Publication date: Available online 12 February 2020Source: Sleep Medicine ReviewsAuthor(s): Sarah K. Schäfer, Benedikt E. Wirth, Marlene Staginnus, Nicolas Becker, Tanja Michael, M. Roxanne SoppSummaryNumerous studies have shown that post-learning sleep enhances visual episodic recognition memory. However, it remains unclear whether this consolidation benefit is moderated by the emotional valence of the learned material. To clarify whether sleep selectively enhances memory for emotional material, we conducted a meta-analysis including N=1,059 post-sleep/wake observations. Overall, our results do not support this hypothesis. When only studies with a sleep group/wake group comparison were included in the analysis (k=22), the retention advantage for emotional (negative/positive) over neutral material was not significantly different between sleep and wake groups. When studies without wake groups were included in the analysis after statistical estimation of wake-group parameters, the retention advantage for emotional material was significantly larger in wake groups than in sleep groups (k=34). Interestingly, however, an additional analysis of eight studies investigating the selective effects of rapid-eye-movement sleep and slow-wave sleep on post-interval emotional memory provided evidence for a selective enhancement of emotional over neutral memory performance after rapid-eye-movement sleep compared to slow-wave sleep. These findings suggest that sleep does not generally enhance visual recognition memory for emotional stimuli. However, the result pattern is consistent with the idea that specific sleep stages preferentially enhance consolidation of emotional and neutral material, respectively.
  • Sleep during development: sex and gender differences
    • Abstract: Publication date: Available online 11 February 2020Source: Sleep Medicine ReviewsAuthor(s): Patricia Franco, Benjamin Putois, Aurore Guyon, Aude Raoux, Maria Papadopoulou, Anne Guignard-Perret, Flora Bat-Pitault, Sarah Hartley, Sabine PlancoulaineSummarySleep occupies a substantial proportion of life. Sleep modifications parallel brain development during childhood. Sex and gender differences have been reported in brain development and many clinical and psychosocial conditions. This narrative review provides insight into the differences between girls and boys in terms of brain maturation and plasticity related to sleep and sleep characteristics (physiology, sleep duration) during development.
  • The Role of Tissue Biopsy as a Biomarker in REM Sleep Behavior Disorder
    • Abstract: Publication date: Available online 11 February 2020Source: Sleep Medicine ReviewsAuthor(s): Jennifer Zitser, Christopher Gibbons, Mitchell G. MiglisSummaryPatients with idiopathic REM-sleep behavior disorder (iRBD) are at substantial risk of progressive neurodegenerative disease of α-synuclein pathology. Longitudinal studies have demonstrated that abnormal α-synuclein deposition occurs early in the course of disease and may precede the appearance of motor symptoms by several decades. This provides rationale for the use of a reliable biomarker to both follow disease progression and to assess treatment response, once disease-modifying treatments become available. Tissue α-synuclein has emerged as a promising candidate, however the utility of α-synuclein detection in tissues accessible to biopsy in iRBD remains unclear. This article summarizes the current literature on the role of tissue biopsy in iRBD, with specific focus on its potential role as a biomarker of disease progression and its role in future clinical trials.
  • Sleep in the anxiety-related disorders: A meta-analysis of subjective and
           objective research
    • Abstract: Publication date: Available online 11 February 2020Source: Sleep Medicine ReviewsAuthor(s): Rebecca C. Cox, Bunmi O. OlatunjiSummaryAlthough sleep disturbance is implicated in psychopathology, its role in anxiety-related disorders remains unclear. The present meta-analysis characterizes sleep disturbance in anxiety-related disorders collectively and individually. Subjective measures of total sleep time and sleep continuity were included with objective measures. Results indicate a large effect for increased subjective sleep disturbance (g = 2.16), medium effects for decreased total sleep time (g = -.40) and sleep continuity (g = -.49), and a small effect for decreased sleep depth (g = -.20) in anxiety-related disorders compared to healthy controls. Each anxiety-related disorder exhibited a distinct sleep disturbance pattern, suggesting that sleep may facilitate identification of unique biopsychological underpinnings. Effects were not moderated by comorbid depression and were similar in magnitude to those found for depression. Sleep disturbances, particularly decreased sleep continuity, may be a key pathology in the anxiety-related disorders that could highlight novel etiological mechanisms and intervention targets.
  • Sleep in Parkinson's disease: A systematic review and meta-analysis of
           polysomnographic findings
    • Abstract: Publication date: Available online 11 February 2020Source: Sleep Medicine ReviewsAuthor(s): Ye Zhang, Rong Ren, Larry D. Sanford, Linghui Yang, Junying Zhou, Lu Tan, Taomei Li, Jihui Zhang, Yun-Kwok Wing, Jie Shi, Lin Lu, Xiangdong TangSummaryPolysomnographic studies have been conducted to explore sleep changes in Parkinson’s disease (PD), but the relationships between sleep disturbances and PD are imperfectly understood. We conducted a systematic review of the literature exploring polysomnographic differences between PD patients and controls in EMBASE, MEDLINE, All EBM databases, CINAHL, and PsycIFNO. 67 studies were identified for systematic review, 63 of which were used for meta-analysis. Meta-analyses revealed significant reductions in total sleep time, sleep efficiency, N2 percentage, slow wave sleep, rapid eye movement sleep (REM) percentage, and increases in wake time after sleep onset, N1 percentage, REM latency, apnea hypopnea index, and periodic limb movement index in PD patients compared with controls. There were no remarkable differences in sleep continuity or sleep architecture between PD patients with and without REM sleep behavior disorder (RBD). Our study suggests that PD patients have poor sleep quality and quantity. Sex, age, disease duration, presence of RBD, medication status, cognitive impairment, and adaptation night are factors that contributed to heterogeneity between studies.
  • Physical activity and sleep are inconsistently related in healthy
           children: A systematic review and meta-analysis
    • Abstract: Publication date: Available online 11 February 2020Source: Sleep Medicine ReviewsAuthor(s): Devan Antczak, Chris Lonsdale, Jane Lee, Toni Hilland, Mitch J. Duncan, Borja del Pozo Cruz, Ryan M. Hulteen, Philip D. Parker, Taren SandersSummaryPhysical activity is considered an effective method to improve sleep quality in adolescents and adults. However, there is mixed evidence among children. Our objectives were to investigate this association in children and to examine potential moderating variables. Eight databases were systematically searched, and we included all study designs with a sample of healthy children ages 3-13 years-old. We identified 47 studies for meta-analysis. Overall, we found little association between physical activity and sleep (r = .02, 95% confidence interval = -.03 to .07). There was a high amount of heterogeneity in the overall model (I2 = 93%). However, none of the examined variables significantly moderated the overall effect, including age, gender, risk of bias, study quality, measurement methodology, study direction, and publication year. Exploratory analyses showed some weak, but statistically significant associations for vigorous physical activity with sleep (r = .09, 95% CI = .01 to .17, I2 = 66.3%), specifically sleep duration (r = .07, 95% CI = .00 to .14, I2 = 41.1%). High heterogeneity and the lack of experimental research suggest our findings should be interpreted with caution. The current evidence, however, shows little support for an association between physical activity and sleep in children.
  • Positive Airway Pressure Adherence in Pediatric Obstructive Sleep Apnea: A
           Systematic Scoping Review
    • Abstract: Publication date: Available online 8 February 2020Source: Sleep Medicine ReviewsAuthor(s): Alexa J. Watach, Melissa S. Xanthopoulos, Olufunke Afolabi-Brown, Bruno Saconi, Kathleen A. Fox, Maylene Qiu, Amy M. SawyerSummaryPositive airway pressure (PAP) therapy is a commonly prescribed treatment for pediatric obstructive sleep apnea (OSA). Negative health consequences associated with untreated OSA make understanding the utilization of PAP therapy imperative. The aim of this review was to describe PAP use in children and adolescents with OSA, explore factors that influence use, and describe published scientific or clinical approaches to improve use. Among 20 studies, average PAP adherence was 56.9% (range, 24-87%). PAP use averaged 4.0 hours (SD= 3.1) to 5.2 hours (SD= 3.4) per night. Cautious consideration of summary estimates of PAP use is necessary as studies were heterogeneous and adherence definitions widely varied across studies. Age, sex, and developmental delay were the only factors associated with PAP use in more than one study. The majority of approaches to improve use were program evaluations rather than scientifically tested interventions. This review identified critical gaps in the existing literature and sets forth a research agenda for the future.
  • Toward a Personalized Medicine Approach to Trauma-Related Nightmares
    • Abstract: Publication date: Available online 25 January 2020Source: Sleep Medicine ReviewsAuthor(s): Murray A. Raskind
  • Commentary on Ge et al. “Insomnia and risk of mortality from all-cause,
           cardiovascular disease, and cancer: Systematic review and meta-analysis of
           prospective cohort studies”
    • Abstract: Publication date: Available online 8 January 2020Source: Sleep Medicine ReviewsAuthor(s): Qibiao Wu, Elaine Lai-Han Leung
  • Obstructive sleep apnea, cognition and Alzheimer's disease: A systematic
           review integrating three decades of multidisciplinary research
    • Abstract: Publication date: April 2020Source: Sleep Medicine Reviews, Volume 50Author(s): Omonigho M. Bubu, Andreia G. Andrade, Ogie Q. Umasabor-Bubu, Megan M. Hogan, Arlener D. Turner, Mony J. de Leon, Gbenga Ogedegbe, Indu Ayappa, Girardin Jean-Louis G, Melinda L. Jackson, Andrew W. Varga, Ricardo S. OsorioSummaryIncreasing evidence links cognitive-decline and Alzheimer's disease (AD) to various sleep disorders, including obstructive sleep apnea (OSA). With increasing age, there are substantial differences in OSA's prevalence, associated comorbidities and phenotypic presentation. An important question for sleep and AD researchers is whether OSA's heterogeneity results in varying cognitive-outcomes in older-adults compared to middle-aged adults. In this review, we systematically integrated research examining OSA and cognition, mild cognitive-impairment (MCI) and AD/AD biomarkers; including the effects of continuous positive airway pressure (CPAP) treatment, particularly focusing on characterizing the heterogeneity of OSA and its cognitive-outcomes. Broadly, in middle-aged adults, OSA is often associated with mild impairment in attention, memory and executive function. In older-adults, OSA is not associated with any particular pattern of cognitive-impairment at cross-section; however, OSA is associated with the development of MCI or AD with symptomatic patients who have a higher likelihood of associated disturbed sleep/cognitive-impairment driving these findings. CPAP treatment may be effective in improving cognition in OSA patients with AD. Recent trends demonstrate links between OSA and AD-biomarkers of neurodegeneration across all age-groups. These distinct patterns provide the foundation for envisioning better characterization of OSA and the need for more sensitive/novel sleep-dependent cognitive assessments to assess OSA-related cognitive-impairment.
  • Polysomnographic features of pregnancy: A systematic review
    • Abstract: Publication date: April 2020Source: Sleep Medicine Reviews, Volume 50Author(s): Corrado Garbazza, Sandra Hackethal, Silvia Riccardi, Christian Cajochen, Alessandro Cicolin, Armando D'Agostino, Fabio Cirignotta, Mauro ManconiSummarySymptoms of sleep disturbances are common among pregnant women and generally worsen across gestation. Pregnancy-related sleep disorders are not only associated with a poor quality of life of the affected mothers, but also with adverse perinatal outcomes, including perinatal depression, gestational diabetes, preeclampsia, and preterm birth. The current knowledge about the impact of sleep disorders during pregnancy largely derives from the results of sleep surveys conducted in various populations. However, the number of studies examining changes in objective sleep variables during pregnancy via polysomnography has progressively increased in recent years.Here we systematically reviewed the polysomnographic studies available in the literature with the aim to describe the sleep pattern and to identify possible markers of sleep disruption in pregnant women.Based on our analysis, subjective worsening of sleep quality across gestation is related to objective changes in sleep macrostructure, which become particularly evident in the third trimester. Pregnancy per se does not represent an independent risk factor for developing major polysomnography-assessed sleep disorders in otherwise healthy women. However, in women presenting predisposing factors, such as obesity or hypertension, physiological changes occurring during pregnancy may contribute to the onset of pathological conditions, especially sleep-disordered breathing, which must be carefully considered.
  • Insights into the effects of sleep disordered breathing on the brain in
           infants and children: Imaging and cerebral oxygenation measurements
    • Abstract: Publication date: April 2020Source: Sleep Medicine Reviews, Volume 50Author(s): Lisa M. Walter, Kelsee L. Shepherd, Alicia Yee, Rosemary S.C. HorneSummarySleep disordered breathing (SDB) is a common condition in infants and children. SDB encompasses a spectrum of respiratory disorders, which are defined as either obstructive or central in nature. Obstructive SDB ranges in severity from primary snoring (PS), to obstructive sleep apnea (OSA). There are a number of conditions characterized by central sleep apnea (CSA), including but not limited to periodic breathing in infants, Arnold Chiari malformations, and idiopathic CSA. SDB is associated with adverse cardiovascular and neurocognitive outcomes believed to be the consequence of the repeated cycles of hypoxia followed by reperfusion, hypercarbia, and sleep fragmentation. The peripheral hypoxia in individuals with SDB may not reflect cerebral oxygenation, and near infrared spectroscopy (NIRS) has been used to determine oxygen delivery and uptake in the brain. Neuroimaging in the form of structural and functional magnetic resonance imaging (MRI, fMRI), diffusion tensor imaging (DTI), and magnetic resonance spectroscopy (MRS) have become widely used to determine the structural, functional and chemical changes in the brain associated with SDB. This review will explore the relationship between central and obstructive SDB and changes in cerebral oxygenation together with changes in brain structure and function, in infants and children. It is important to identify any adverse effects so that they can be mitigated as early as possible to minimize any detrimental effects on the developing brain.
  • Reply to Wu et al.: Commentary on insomnia and risk of mortality
    • Abstract: Publication date: Available online 27 December 2019Source: Sleep Medicine ReviewsAuthor(s): Jiancheng Wang, Bei Pan, Long Ge
  • REM sleep vs exploratory wakefulness: alternatives within adult
           ‘sleep debt’ '
    • Abstract: Publication date: Available online 23 December 2019Source: Sleep Medicine ReviewsAuthor(s): Jim HorneSummaryOur declining sleep duration over early human infant development is largely through REM sleep (REM), loss, not of nonREM. It coincides with the infant’s increasing locomotion providing for multisensory inputs (‘exploratory wakefulness’ - EW), together facilitating neural restructuring and behavioural adaptations (‘neuroplasticity’). EW also involves curiosity, novelty, navigation, spatial memory, associated emotions, and feeding; all having brain processes particularly active in REM. It is proposed that: (i) REM is a proxy for EW in facilitating neuroplasticity; (ii) necessitating REM having a locomotor output, actively inhibited (the atonia); (iii) human adults retain many (neotenous) infant characteristics including large amounts of REM towards the end of usual sleep, where REM’s qualitative changes indicate reduced sleep pressure, (iv) as in infancy, some of our adult REM remains replaceable by EW (without REM rebounds), mostly in this final REM episode whenever EW need prevails. Accordingly, our adult sleep duration is adaptable to habitual shortening via this REM episode substituted by purposeful EW, which could provide extra (day)light exposure for circadian synchrony. Such processes may underlie seasonally shorter (6h) sleep, eg in hunter-gather people. This flexibility of REM questions the extent of our western ‘chronic sleep debt’. Evidence is provided to counter claims that this absent REM would cause obesity and related disorders. 200w.
  • Non-pharmacological treatment for insomnia following acquired brain
           injury: a systematic review
    • Abstract: Publication date: Available online 19 December 2019Source: Sleep Medicine ReviewsAuthor(s): Marthe E. Ford, Erny Groet, Joost G. Daams, Gert J. Geurtsen, Coen A.M. Van Bennekom, Eus J.W. Van SomerenSummaryInsomnia symptoms following acquired brain injury are serious and common, associated with cognitive and emotional complaints. This systematic review aims to summarize and appraise the current knowledge regarding the efficacy of non-pharmacological treatments for insomnia after traumatic brain injury and stroke in adults. A systematic search in the electronic databases of Medline, PsycINFO and Embase was conducted on January 15, 2019. The search strategy included traumatic brain injury or stroke and a combination of keywords and Boolean operators to represent the concept of insomnia. Articles were restricted to those in English and study populations of human adults. A total of 4341 studies were found, of which 16 were included, representing seven different non-pharmacological treatments. While the quality and quantity of the studies does not allow for firm conclusions, the outcomes suggest that cognitive behavioural therapy improves insomnia and sleep quality. The results highlight the need for larger studies of better methodological quality on non-pharmacological interventions for insomnia following brain injury.
  • REM sleep behavior disorder in narcolepsy: a secondary form or an
           intrinsic feature'
    • Abstract: Publication date: Available online 19 December 2019Source: Sleep Medicine ReviewsAuthor(s): Elena Antelmi;, Fabio Pizza, Christian Franceschini, Raffaele Ferri, Giuseppe PlazziSummaryDisrupted nighttime sleep is one of the pentad of symptoms defining Narcolepsy. REM sleep behavior disorder (RBD) largely contributes to night sleep disruption and narcolepsy is the most common cause of secondary RBD. However, RBD linked to narcolepsy (N-RBD) has been insufficiently characterized, leaving unsolved a number of issues. Indeed, it is still debated whether N-RBD is an intrinsic feature of narcolepsy, as indubitable for cataplexy, and therefore strictly linked to the cerebrospinal fluid hypocretin-1 (CSF hcrt-1) deficiency, or an associated feature, with a still unclear pathophysiology. The current review aims at rendering a comprehensive state–of-the-art of N-RBD, highlighting the open and unsettled topics. RBD reportedly affects 30-60% of patients with Narcolepsy type 1 (NT1), but it may be seen also in Narcolepsy type 2 (NT2). When compared to idiopathic/isolated RBD (iRBD), N-RBD has been reported to be characterized by less energetic and quieter episode, which however occur with the same probability in the first and the second part of the night and sometime even subcontinuously. N-RBD patients are generally younger than those with iRBD. N-RBD has been putatively linked to wake-sleep instability due to CSF hcrt-1 deficiency, but this latter by itself cannot explain completely the phenomenon as N-RBD has not been universally linked to low CSF hcrt-1 levels and it may be observed also in NT2. Therefore, other factors may probably play a role and further studies are needed to clarify this issue. In addition, therapeutic options have been poorly investigated.
  • Pre-sleep cognitive activity in adults: A systematic review
    • Abstract: Publication date: Available online 17 December 2019Source: Sleep Medicine ReviewsAuthor(s): Alexandre Lemyre, Florence Belzile, Madeleine Landry, Célyne H. Bastien, Luc BeaudoinSummaryThis systematic review focuses on three themes: 1) the nature of pre-sleep cognitive activity in good sleepers and individuals with insomnia, 2) the links between measures of pre-sleep cognitive activity and sleep onset latency (SOL) or insomnia, and 3) the effect of manipulating pre-sleep cognitive activity on SOL or insomnia. Regarding the first theme, mentation reports have been collected in a sleep laboratory, with an ambulatory monitoring device, or using a voice-activated tape-recorder. Normal transition to sleep is characterized by sensorial imagery, deactivation of higher cognitive processes, and hallucinations. Moreover, pre-sleep thoughts in individuals with insomnia frequently relate to planning or problem-solving, and are more unpleasant than in good sleepers. Regarding the second theme, twelve questionnaires and three interviews were identified. Insomnia is associated with more thoughts interfering with sleep, counterfactual processing, worries, maladaptive thought control strategies, covert monitoring, and cognitive arousal. Regarding the third theme, several strategies have been tested: mental imagery, hypnosis, paradoxical intention, articulatory suppression, ordinary suppression, and distraction. Their effect is either beneficial, negligible, or detrimental. Future research should focus on the mechanisms through which some forms of cognitive activity affect sleep onset latency.
  • Many naps, one nap, none: A systematic review and meta-analysis of napping
           patterns in children 0-12 years
    • Abstract: Publication date: Available online 29 November 2019Source: Sleep Medicine ReviewsAuthor(s): Sally Staton, Peter S. Rankin, Mollie Harding, Simon S. Smith, Emily Westwood, Monique K. LeBourgeois, Karen J. ThorpeSummaryThe onset of monophasic sleep, in which napping ceases and sleep consolidates into a single night period, is a key developmental milestone of childhood. Yet to date, there is little consensus regarding the timing of cessation of napping in children. The aim of the current study is to examine global evidence regarding napping patterns in childhood, and, through meta-analysis, describe patterns of napping cessation and duration observed in children aged 0-12 years. A systematic search of all published, original research articles reporting children’s napping patterns, by age, was conducted. The quality of studies was assessed, and meta-analysis of eligible studies undertaken. Risk of bias and heterogeneity of measurement was high. Current evidence indicates that less than 2.5% of children cease napping prior to age 2, while 94% cease napping by age 5. The preschool period (3-5 years; 36-60 months) represents a particularly dynamic period in napping cessation, with large variation in rates of napping across studies evidencing potential ecological effects. Future studies should focus on understanding of the underlying mechanisms explaining individual variations in napping patterns and the extent to which patterns of napping may represent a marker of child development.
  • Comparative efficacy of imagery rehearsal therapy and prazosin in the
           treatment of trauma-related nightmares in adults: A meta-analysis of
           randomized controlled trials
    • Abstract: Publication date: Available online 28 November 2019Source: Sleep Medicine ReviewsAuthor(s): D.E. Yücel, A.A.P. van Emmerik, C. Souama, J. LanceeSummaryPharmacological treatment with prazosin and psychological treatment with imagery rehearsal therapy (IRT) are the two main treatments of posttraumatic nightmares. The American Academy of Sleep Medicine task force recently listed IRT as the recommended treatment for trauma-related nightmares and changed the recommendation of prazosin to ‘may be used’. This new recommendation was based on a single prazosin trial and not on a meta-analytic review of all available trials. The current meta-analysis aims to fill this gap in the literature. Eight studies on IRT and seven studies on prazosin (N = 1.078) were analyzed based on the random effects model. Relative to control groups, prazosin had a moderate to large effect on nightmare frequency (g = 0.61), posttraumatic stress symptoms (g = 0.81), and sleep quality (g = 0.85). IRT showed small to moderate effects on nightmare frequency (g = 0.51), posttraumatic symptoms (g = 0.31), and sleep quality (g = 0.51). No significant differences in effect were observed between prazosin and IRT on any of these outcomes (all p’s> .10). It is concluded that downgrading the recommendation of prazosin may be a premature decision and that the aggregated results in this meta-analysis clearly show efficacy of both treatments.
  • Sex Differences in Obstructive Sleep Apnea: Is it a menopause issue'
    • Abstract: Publication date: Available online 20 November 2019Source: Sleep Medicine ReviewsAuthor(s): Sophia E. Schiza, Izolde Bouloukaki
  • Melatonergic agents in the prevention of delirium: A network meta-analysis
           of randomized controlled trials
    • Abstract: Publication date: Available online 14 November 2019Source: Sleep Medicine ReviewsAuthor(s): Chun-Pai Yang, Ping-Tao Tseng, Jane Pei-Chen Chang, Huanxing Su, Senthil Kumaran Satyanarayanan, Kuan-Pin SuSummaryDisruption of the sleep-wake cycle is a risk factor and a prodromal indicator of delirium. Melatonergic agents may thus play a role in the prevention of delirium. Based upon literature search on eight databases, this systemic review and frequentist model network meta-analysis (NMA) aimed to determine the efficacy and tolerability of melatonergic agents in delirium prevention. Six randomized controlled trials (RCTs) were included with a total of 913 adult participants (mean age = 78.8, mean female proportion = 59.4%) investigating the preventive effects of melatonergic agents in patients with high risks of developing delirium. The outcomes of NMA demonstrated significant preventive effects with 5 mg/day of melatonin [Odds Ratio (OR) = 0.21, 95% Confidence Intervals (CIs): 0.07 to 0.64], melatonin (0.5 mg/day) [OR = 0.16 (95% CIs: 0.03 to 0.75)], and ramelteon (8 mg/day) [OR = 0.28 (95% CIs: 0.12 to 0.65)] against placebo groups. According to the surface under the cumulative ranking curve (SUCRA), 0.5 mg/day of melatonin was associated with the best preventive effect. Our findings provided the rationale for recommending low-dose melatonergic agents for delirium prevention in the practice guidelines.
  • Obstructive Sleep Apnea And Venous Thromboembolism: Overview Of An
           Emerging Relationship
    • Abstract: Publication date: Available online 14 November 2019Source: Sleep Medicine ReviewsAuthor(s): Alberto Alonso-Fernández, Nuria Toledo-Pons, Francisco García-RíoSummaryObstructive sleep apnea (OSA) is a risk factor for cardiovascular syndromes. Venous thromboembolism (VTE) is a chronic disease, and pulmonary embolism (PE) is the major expression of VTE and the third most frequent cardiovascular disease. An increasing and emerging number of cross-sectional and longitudinal studies have linked OSA to VTE, and have postulated different putative pathways to explain how OSA might increase the risk of PE.We aim to provide a critical overview of the existing evidence about the complex relationship between these two conditions, with some factors and confounding variables still to be clarified. A global interpretation of the studies shows OSA is highly prevalent in VTE patients. This association represents a major public health burden, given the high prevalence and the mortality rates of both disorders. Although still not proven, OSA may induce a persistent hypercoagulable state that may contribute to increase VTE rate and its recurrence. Coagulant activity, platelet function and fibrinolytic system may improve after continuous positive airway pressure (CPAP) in OSA. However, there is a still a lack of randomized controlled trials to evaluate the potential of CPAP and/or extend oral anticoagulation to reduce PE incidence, recurrence and mortality by PE in patients with OSA.
  • Systematic review of the efficacy of commonly prescribed pharmacological
           treatments for primary treatment of sleep disturbance in patients with
           diagnosed autoimmune disease
    • Abstract: Publication date: Available online 14 November 2019Source: Sleep Medicine ReviewsAuthor(s): Amy C. Reynolds, Nathaniel S. Marshall, Catherine L. Hill, Robert J. AdamsSummarySleep disturbances are commonly reported by patients with autoimmune disease, and are negatively related to both disease activity and quality of life. Despite the potential for sleep disturbance to exacerbate inflammatory pathways, acute management of sleep disturbance with pharmacological aids is not well understood in this patient group. The objective of this review was to determine the efficacy of pharmacological treatments for sleep disturbance to improve sleep outcomes in adult patients with diagnosed autoimmune disease. Four databases and grey literature were searched for randomized controlled trials which used a pharmacological treatment specifically to treat sleep disturbance in patients with diagnosed autoimmune disease, both in hospitalized and non-hospitalized settings. A sleep outcome was required to be the primary endpoint of the study. Of the 409 studies identified, a total of six were included in the systematic review. Risk of bias across the studies was largely unclear, making an assessment challenging; meta-analysis was not undertaken due to clinical and methodological heterogeneity between studies. While there appeared to be perceived improvement in self-reported sleep quantity and quality in existing studies with pharmacological treatment, there was also evidence of placebo effect on some measures. Relatively small numbers of patients have undergone gold-standard polysomnographic (PSG) recording of sleep which limits our knowledge of objectively determined sleep quantity and quality in patients with autoimmune disease receiving pharmacological treatment for sleep disturbance. Presently there is insufficient evidence to determine whether pharmacological treatment of sleep disturbance is beneficial for improving sleep quantity and quality in this patient group beyond rheumatoid arthritis.
  • Interventions for sleep problems during pregnancy: a systematic review
    • Abstract: Publication date: Available online 14 November 2019Source: Sleep Medicine ReviewsAuthor(s): Valeria Bacaro, Fee Benz, Andrea Pappaccogli, Paola De Bartolo, Anna F. Johann, Laura Palagini, Caterina Lombardo, Bernd Feige, Dieter Riemann, Chiara BaglioniSummarySleep problems during pregnancy are prevalent and could be linked to negative outcomes during pregnancy or post-partum. However, these complaints are often underdiagnosed and undertreated. This review aimed to systematically assess the effectiveness of different interventions to ameliorate poor sleep quality and insomnia during pregnancy.Pubmed, PsycINFO and Medline databases were systematically searched without publication period restriction until 3rd May 2019. Eligible studies had to: include pregnant women of any age and gestational age; use clinical intervention designs targeted at improving sleep outcome; report pre- and post-treatment data for one or more sleep-related outcomes; be published in English, Italian, German, Spanish, or French.Sixteen studies were selected including 1252 expecting mothers. Studies evaluated the efficacy of various interventions: cognitive behavioral interventions for insomnia (4); pharmacotherapy (1); acupuncture (1); mindfulness and yoga (3); relaxation (5) and herbal medication (2). Only six were randomized controlled trials, and only four evaluated longitudinal outcomes. Preliminary support was found for all interventions, but our knowledge is still too limited by lack of evidence.There is an utmost urgency to perform high-quality randomized controlled trials for insomnia interventions during pregnancy and to implement effective programs in standard gynecological care.
  • Continuing to strive for timeliness, quality and impact
    • Abstract: Publication date: Available online 13 November 2019Source: Sleep Medicine ReviewsAuthor(s): Michael V. Vitiello
  • A systematic review of the accuracy of sleep wearable devices for
           estimating sleep onset
    • Abstract: Publication date: Available online 6 November 2019Source: Sleep Medicine ReviewsAuthor(s): Hannah Scott, Leon Lack, Nicole LovatoSummaryThe accurate estimation of sleep onset is required for many purposes, including the administration of a behavioural treatment for insomnia called Intensive Sleep Retraining, facilitating power naps, and conducting objective daytime sleepiness tests. Specialised equipment and trained individuals are presently required to administer these applications in the laboratory: a costly and impractical procedure which limits their utility in practice. A wearable device could be used to administer these applications outside the laboratory, increasing accessibility. This systematic review aimed to identify practical wearable devices that accurately estimate sleep onset. The search strategy identified seventy-one articles which compared estimations of sleep onset latency from wearable devices against polysomnography. Actigraphy devices produced average estimations of sleep onset latency that were often not significantly different from polysomnography, but there was large inter-individual variability depending on participant characteristics. As expected, electroencephalography-based devices produced more accurate and less variable estimates. Devices that measured behavioural aspects of sleep onset consistently overestimated PSG-determined sleep onset latency, but to a comparatively low degree. This sleep measurement method could be deployed in a simple wearable device to accurately estimate sleep onset and administer Intensive Sleep Retraining, power naps, and objective daytime sleepiness tests outside the laboratory setting.
  • The role of sleep in the pathophysiology of nocturnal enuresis
    • Abstract: Publication date: Available online 6 November 2019Source: Sleep Medicine ReviewsAuthor(s): Malthe Jessen Pedersen, Søren Rittig, Poul Jørgen Jennum, Konstantinos KamperisSummaryNocturnal enuresis (NE) is a common condition affecting 5-10 % of all 7-year-old children. NE pathophysiology relies on three main factors, abnormal bladder function, excess urine production during sleep and the inability to awaken to the signals of a full bladder. The aim of this review is to evaluate the connection between sleep and its structure and the pathophysiology of NE.NE often occurs early at night and primarily in sleep stage 2 and “deep sleep”. Although sleep stage distribution seems similar between NE and healthy children recent studies indicate differences in sleep microstructure. Several lines of research support the common notion among parents that children with NE are difficult to awaken. Moreover, children with NE and nocturnal polyuria differ in terms of hemodynamics and possibly autonomic activation at night compared to healthy controls and the hypothesis has formed that these changes are attributable to different sleep characteristics. In support of this hypothesis, children with NE often suffer sleep disordered breathing, as well as disturbed sleep due to awakenings and arousals. Periodic limb movements (PLM) have been seen in children with refractory enuresis but the clinical significance remains unclear.
  • Phenotypes of responders to mandibular advancement device therapy in
           obstructive sleep apnea patients: a systematic review and meta-analysis
    • Abstract: Publication date: Available online 6 November 2019Source: Sleep Medicine ReviewsAuthor(s): Hui Chen, Danny J. Eckert, Paul F. van der Stelt, Jing Guo, Shaohua Ge, Elham Emami, Fernanda R. Almeida, Nelly T. HuynhSummaryMandibular advancement device (MAD) therapy is the most commonly used non-continuous positive airway pressure (CPAP) treatment for obstructive sleep apnea (OSA). Although OSA patients prefer MAD over CPAP, on average over one third have minimal or no major reduction in OSA severity with MAD therapy. Improved understanding of responder characteristics (or “phenotypes”) to MAD may facilitate more efficient use of limited medical resources and optimize treatment efficacy.The aim of this review is to describe the baseline phenotypic characteristics of responders to MAD therapy in OSA patients. Pubmed, Web of Science, EMBASE, Scopus were searched for eligible studies published until Feb 2019. A total of 650 studies were identified. 41 studies were included in this review and meta-analysis. The quality of the studies was assessed using the risk of bias assessment tool for non-randomized studies (RoBANS). Based on meta-analysis, the responders to MAD therapy had certain clinical phenotypic characteristics: lower age (95% CI: -4.55 to -1.62, p
  • SLEEP AND THE GH/IGF-1 AXIS: Consequences and countermeasures of sleep
    • Abstract: Publication date: Available online 1 November 2019Source: Sleep Medicine ReviewsAuthor(s): Mounir Chennaoui, Damien Léger, Danielle Gomez-MerinoSummaryThis article presents an up-to-date review of the state-of-the-art knowledge regarding the effect of sleep on the anabolic growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis. This axis is involved in learning and memory and neuroprotection at the central level, and in the crosstalk between sleep and the immune system, with respect to its anti-inflammatory properties. We also aim to provide insight into the consequences of sleep loss on cognitive capacities in healthy individuals and patients with obstructive sleep apnea (OSA), regarding the mechanistic association with the GH/IGF-1 axis. Finally, this review examines the inflammatory/endocrine pathways that are affected by sleep loss, and which may consequently interact with the GH/IGF-1 axis.The deleterious effects of sleep loss include fatigue, and can cause several adverse age-dependent health outcomes. It is therefore important to improve our understanding of the fundamental physiology underlying these effects in order to better apply non-pharmacological countermeasures (e.g. sleep strategies, exercise training, continuous positive airway pressure therapy) as well as pharmacological solutions, so as to limit the deleterious consequences of sleep loss/disorders.
  • Associations of Screen Time, Sedentary Time and Physical Activity with
           Sleep in Under 5s: A Systematic Review and meta-analysis
    • Abstract: Publication date: Available online 1 November 2019Source: Sleep Medicine ReviewsAuthor(s): Xanne Janssen, Anne Martin, Adrienne R. Hughes, Catherine M. Hill, Grigorios Kotronoulas, Kathryn R. HeskethSummarySleep is crucial to children's health and development. Reduced physical activity and increased screen time adversely impact older children’s sleep, but little is known about these associations in children under 5 years. This systematic review examined the association between screen time/movement behaviors (sedentary behavior, physical activity) and sleep outcomes in infants (0-1 year); toddlers (1-2 years); and preschoolers (3-4 years). Evidence was selected according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and synthesized using vote counting based on the direction of association. Quality assessment and a Grading of Recommendations, Assessment, Development and Evaluation was performed, stratified according to child age, exposure and outcome measure. Thirty-one papers were included. Results indicate that screen time is associated with poorer sleep outcomes in infants, toddlers and preschoolers. Meta-analysis confirmed these unfavorable associations in infants and toddlers but not preschoolers. For movement behaviors results were mixed, though physical activity and outdoor play in particular were favorably associated with most sleep outcomes in toddlers and preschoolers. Overall, quality of evidence was very low, with strongest evidence for daily/evening screen time use in toddlers and preschoolers. Although high-quality experimental evidence is required, our findings should prompt parents, clinicians and educators to encourage sleep-promoting behaviors (e.g. less evening screen time) in the under 5s.
  • Role of Menopause and Hormone Replacement Therapy in Sleep-disordered
    • Abstract: Publication date: Available online 31 October 2019Source: Sleep Medicine ReviewsAuthor(s): Eva Lindberg, Maria R. Bonsignore, Päivi Polo-KantolaSummaryThere are suggestions that the loss of female sex hormones following menopause is critical for the development or progression of sleep-disordered breathing (SDB). We conducted a review of the literature on the role of menopause and hormone replacement therapy (HRT) in SDB risk. There is an increase in SDB during the menopausal transition period, but data on an effect beyond that of increasing age and changes in body habitus are weak or absent. Early community-based, observational studies reported a protective effect by HRT on SDB prevalence, but this could possibly be explained as a healthy user effect. Interventional studies of the effect of HRT on SDB are sparse, with only a few randomized placebo-controlled studies, often performed on small samples of women without clinically significant SDB. HRT regimens have varied and all the studies are fairly old. They do not definitely assure the alleviation of SDB and HRT cannot thus be recommended as treatment for SDB. It is concluded that there is no evidence that female sex hormone changes during menopause per se are able to explain the increase in SDB in midlife women and conclusions on the effect of HRT on SDB cannot be drawn from the current literature.
  • Sleep EEG oscillations in neurodevelopmental disorders without
           intellectual disabilities
    • Abstract: Publication date: Available online 30 October 2019Source: Sleep Medicine ReviewsAuthor(s): Maurizio Gorgoni, Serena Scarpelli, Flaminia Reda, Luigi De GennaroSummaryNeurodevelopmental disorders (NDDs) are often characterised by sleep problems, and recent evidence indicates alterations of the sleep electroencephalographic (EEG) oscillations in these patients. Sleep microstructure plays a crucial role in cognitive functioning and brain maturation. In this view, modifications in sleep EEG oscillations in NDDs could further impair the cognitive maturation process in these patients. We provide an overview of sleep microstructure alterations observed in three NDDs without intellectual disabilities (attention-deficit/hyperactivity disorder, high-functioning autism/Asperger syndrome and developmental dyslexia) and their relationships with the disorders’ phenomenology. For each NDD, we discuss empirical evidence of altered EEG oscillations, and we consider their interaction with patients’ cognitive and behavioural functioning, with the aim to elucidate their functional meaning. We highlight the limits of the present literature and propose possible future directions while underlining the clinical relevance of the research in this field. Beyond confirming the importance of sleep management in atypically developing children, the review findings suggest that sleep EEG oscillations in NDDs could become a target for specific clinical intervention.
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Heriot-Watt University
Edinburgh, EH14 4AS, UK
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