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RESPIRATORY DISEASES (102 journals)                     

Showing 1 - 102 of 102 Journals sorted alphabetically
Advances in Respiratory Medicine     Open Access   (Followers: 7)
American Journal of Respiratory and Critical Care Medicine     Full-text available via subscription   (Followers: 254)
American Journal of Respiratory Cell and Molecular Biology     Full-text available via subscription   (Followers: 20)
American Review of Respiratory Disease     Full-text available via subscription   (Followers: 4)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1)
Annals of the American Thoracic Society     Full-text available via subscription   (Followers: 16)
Annals of Thoracic Medicine     Open Access   (Followers: 6)
Archivos de Bronconeumología     Full-text available via subscription  
Archivos de Bronconeumología (English Edition)     Full-text available via subscription   (Followers: 1)
Asthma Research and Practice     Open Access   (Followers: 1)
BMC Pulmonary Medicine     Open Access   (Followers: 4)
BMJ Open Respiratory Research     Open Access   (Followers: 5)
Breathe     Open Access   (Followers: 4)
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine     Hybrid Journal  
Canadian Respiratory Journal     Open Access   (Followers: 2)
Case Reports in Pulmonology     Open Access   (Followers: 3)
Chest     Full-text available via subscription   (Followers: 100)
Chest Disease Reports     Open Access   (Followers: 2)
Chronic Respiratory Disease     Hybrid Journal   (Followers: 9)
Clinical Lung Cancer     Hybrid Journal   (Followers: 5)
Clinical Medicine Insights : Circulatory, Respiratory and Pulmonary Medicine     Open Access   (Followers: 3)
Clinical Pulmonary Medicine     Hybrid Journal   (Followers: 2)
COPD Research and Practice     Open Access   (Followers: 1)
COPD: Journal of Chronic Obstructive Pulmonary Disease     Hybrid Journal   (Followers: 15)
Current Opinion in Pulmonary Medicine     Hybrid Journal   (Followers: 10)
Current Pulmonology Reports     Hybrid Journal  
Current Research in Tuberculosis     Open Access   (Followers: 3)
Current Respiratory Care Reports     Hybrid Journal   (Followers: 1)
Current Respiratory Medicine Reviews     Hybrid Journal   (Followers: 5)
Der Pneumologe     Hybrid Journal   (Followers: 1)
Egyptian Journal of Chest Diseases and Tuberculosis     Open Access   (Followers: 3)
ERJ Open Research     Open Access   (Followers: 2)
Eurasian Journal of Pulmonology     Open Access  
European Clinical Respiratory Journal     Open Access   (Followers: 3)
European Respiratory Journal     Full-text available via subscription   (Followers: 38)
European Respiratory Review     Open Access   (Followers: 7)
Experimental Lung Research     Hybrid Journal  
Expert Review of Respiratory Medicine     Hybrid Journal   (Followers: 5)
Heart & Lung: The Journal of Acute and Critical Care     Hybrid Journal   (Followers: 11)
Heart, Lung and Circulation     Full-text available via subscription   (Followers: 9)
Indian Journal of Respiratory Care     Open Access   (Followers: 3)
Indian Journal of Tuberculosis     Full-text available via subscription  
Influenza and Other Respiratory Viruses     Open Access   (Followers: 3)
International Journal of Chronic Obstructive Pulmonary Disease     Open Access   (Followers: 3)
Journal of Association of Chest Physicians     Open Access   (Followers: 2)
Journal of Asthma     Hybrid Journal   (Followers: 4)
Journal of Asthma Allergy Educators     Hybrid Journal   (Followers: 4)
Journal of Bronchology & Interventional Pulmonology     Hybrid Journal   (Followers: 3)
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases     Open Access  
Journal of Heart and Lung Transplantation     Hybrid Journal   (Followers: 12)
Journal of Respiratory Medicine     Open Access   (Followers: 4)
Journal of Respiratory Research     Open Access   (Followers: 1)
Journal of Tuberculosis Research     Open Access   (Followers: 1)
Jurnal Respirasi     Open Access  
Karger Kompass Pneumologie     Full-text available via subscription   (Followers: 1)
Kindheit und Entwicklung     Hybrid Journal  
Lung     Hybrid Journal   (Followers: 2)
Lung Cancer     Hybrid Journal   (Followers: 15)
Lung Cancer International     Open Access   (Followers: 2)
Lung Cancer: Targets and Therapy     Open Access   (Followers: 3)
Lung India     Open Access   (Followers: 1)
Multidisciplinary Respiratory Medicine     Open Access   (Followers: 4)
npj Primary Care Respiratory Medicine     Open Access   (Followers: 2)
Open Journal of Respiratory Diseases     Open Access   (Followers: 1)
Open Respiratory Medicine Journal     Open Access   (Followers: 1)
Paediatric Respiratory Reviews     Hybrid Journal   (Followers: 11)
Pediatric Quality & Safety     Open Access  
Pediatric Respirology and Critical Care Medicine     Open Access   (Followers: 1)
Pulmonary Circulation     Open Access   (Followers: 4)
Pulmonary Medicine     Open Access   (Followers: 2)
Pulmonary Pharmacology & Therapeutics     Hybrid Journal   (Followers: 2)
Pulmonary Therapy     Open Access   (Followers: 1)
Pulmonology and Respiratory Research     Open Access   (Followers: 1)
Respiratory Care     Full-text available via subscription   (Followers: 10)
Respiratory Investigation     Full-text available via subscription  
Respiratory Medicine     Hybrid Journal   (Followers: 17)
Respiratory Medicine : X     Open Access  
Respiratory Medicine Case Reports     Open Access  
Respiratory Medicine CME     Hybrid Journal  
Respiratory Medicine Extra     Full-text available via subscription   (Followers: 1)
Respiratory Physiology & Neurobiology     Hybrid Journal   (Followers: 4)
Respiratory Research     Open Access   (Followers: 1)
Respirology     Hybrid Journal   (Followers: 5)
Respirology Case Reports     Open Access  
Revista Americana de Medicina Respiratoria     Open Access  
Revista Chilena de Enfermedades Respiratorias     Open Access  
Revista Inspirar     Open Access  
Revista ORL     Open Access  
Revista Portuguesa de Pneumologia     Open Access  
Sarcoidosis Vasculitis and Diffuse Lung Disese     Full-text available via subscription   (Followers: 3)
Seminars in Respiratory and Critical Care Medicine     Hybrid Journal   (Followers: 14)
Sleep Medicine Reviews     Hybrid Journal   (Followers: 17)
The Clinical Respiratory Journal     Hybrid Journal   (Followers: 3)
The International Journal of Tuberculosis and Lung Disease     Full-text available via subscription   (Followers: 8)
The Lancet Respiratory Medicine     Full-text available via subscription   (Followers: 32)
Therapeutic Advances in Chronic Disease     Open Access   (Followers: 7)
Therapeutic Advances in Respiratory Disease     Open Access   (Followers: 1)
Thorax     Hybrid Journal   (Followers: 37)
Translational Respiratory Medicine     Open Access   (Followers: 1)
Tuberculosis     Hybrid Journal   (Followers: 12)
Tuberculosis Research and Treatment     Open Access   (Followers: 3)
Пульмонология     Full-text available via subscription  

           

Similar Journals
Journal Cover
Respiratory Medicine Extra
Number of Followers: 1  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1744-9049
Published by Elsevier Homepage  [3161 journals]
  • Hiatal hernia and respiratory disturbs: Report of case
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 4



      PubDate: 2012-12-17T07:12:26Z
       
  • Pulmonary tuberculosis in a case of Rubinstein–Taybi syndrome
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 4

      Rubinstein–Taybi syndrome is a rare genetic disease characterized by mental deficiency, broad thumbs and toes, short stature, and characteristic facial features. The syndrome has been linked to microdeletion at 16p13.3 encoding CREB-binding protein gene (CREBBP). Most reported cases of Rubinstein–Taybi syndrome are sporadic, with no firm evidence of Mendelian inheritance. We report a case of a 26-year-old male patient of Rubinstein–Taybi syndrome with pulmonary tuberculosis. The occurrence of respiratory infections in patients with this syndrome has been mentioned in the past. Systemic problems involving the respiratory system, feeding and the cardiovascular system have been noted in some individuals with this rare syndrome.

      PubDate: 2012-12-17T07:12:26Z
       
  • Endobronchial argon plasma coagulation for neoplastic airway obstruction
           in a patient requiring supplemental oxygen, ventilatory and hemodynamic
           support
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 4

      Reports on the safety and efficacy of endobronchial argon plasma coagulation (APC) for the treatment of neoplastic airway obstruction in critically ill patients are limited. We describe a case of severe airway stenosis in a patient with esophageal cancer who required high-inspired oxygen concentrations, mechanical ventilatory and hemodynamic support. Relief of obstruction was achieved with APC in the absence of bedside complications. APC can be performed safely for palliative management of obstruction due to endobronchial tumor even in critically ill patients in whom the use of the Nd-YAG laser is precluded.

      PubDate: 2012-12-17T07:12:26Z
       
  • Pulmonary embolism due to liquid silicone: Case report
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 4

      Currently, a rare, non-thrombotic cause of pulmonary embolism is being described, resulting from subcutaneous injection of industrial liquid silicone (Polydimethylsiloxane) carried out illicitly by untrained professionals. The most serious systemic complications are the result of pulmonary involvement, with an average mortality of 24%. We describe a fatal case of pulmonary embolism due to liquid silicone injection, in a transsexual male seen at our institution.

      PubDate: 2012-12-17T07:12:26Z
       
  • Squamous cell lung carcinoma with surrounding pure nonmucinous
           bronchioloalveolar carcinoma (BAC)
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 4

      Bronchioloaveolar cell carcinoma (BAC) was defined by the WHO in 1999 to be a subtype of adenocarcinoma with a pure bronchioloalveolar growth pattern showing no evidence of stromal, vascular, or pleural invasion [Travis WD, Colby TV, Conin B, et al. Bronchioloalveolar carcinoma. In: Sobin LH, editor. WHO international histological classification of tumors, 3rd ed. Copenhagen, Denmark: Springer; 1999. p. 34–8]. Although there were some reports that BAC was presented together with squamous cell carcinoma, this is the first report that it might be transformed from surrounding pure nonmucinous BAC. Physicians should be aware that pure BAC could transform to squamous cell carcinoma, and that such cases might not respond to gefitinib.

      PubDate: 2012-12-17T07:12:26Z
       
  • FDG-PET to monitor early response to infliximab in refractory systemic
           sarcoidosis
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 4

      Background Systemic sarcoidosis can result in dramatic manifestations despite therapeutic escalation. Tumor necrosis factor (TNFα) has a key role in this disease and antagonists of TNFα have been successfully used as an alternative to conventional therapy. We report a case of refractory sarcoidosis with mediastinal, bone and ear, nose, throat (ENT) lesions. Methods In this patient we monitored response to treatment by infusions of the anti-TNFα antibody, infliximab, with fluorine 18-fluorodeoxyglucose positron emission tomography (FDG-PET). Results Early and spectacular response to infliximab was demonstrated by FDG-PET, which evidenced complete response to treatment. Conclusion This case supports use of FDG-PET to evaluate the extent of active disease in refractory sarcoidosis and above all, FDG-PET could be an imaging method of choice showing response to infliximab in refractory sarcoidosis earlier than other imaging techniques.

      PubDate: 2012-12-17T07:12:26Z
       
  • An unusual phenomenon following simple aspiration of pneumothorax
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 4



      PubDate: 2012-12-17T07:12:26Z
       
  • Association of testicular neoplasia and sarcoidosis
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 4

      In this report, we highlight the association of sarcoidosis and testicular cancer in 3 patients and comment on the potential impact of this association on the interpretation of the radiological and pathological findings in suspected cancer. Sarcoidosis, a condition that can coexist with testicular cancer, should always be considered in the differential diagnosis of suspected metastases, particularly as intrathoracic lymphadenopathy may be assumed to represent metastatic disease, which can have radical implications for patient therapy.

      PubDate: 2012-12-17T07:12:26Z
       
  • Unusual cavitary lung lesion in an asymptomatic patient—Case report
           and differential diagnosis
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 4

      An unusual cavitary lung lesion in an asymptomatic and nonsmoker patient is uncommon. In these cases, infectious pathologies should be included in the differential diagnosis. Then, to correctly conduct an investigation, it is important to consider the clinical picture, the radiological images and the epidemiology. This presentation may need a wide variety of tests to establish the final diagnosis. Such a presentation occurs in the following case report.

      PubDate: 2012-12-17T07:12:26Z
       
  • “Nonobstructive” emphysema of the lung
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 4

      An unusual case of smoking-related centrilobular emphysema with normal spirometry. A 64-year-old man presented with severe dyspnoea and respiratory failure. Pulmonary function and mechanics were normal except for a marked reduction in diffusing capacity of the lung. High-resolution CT scan showed diffuse centrilobular emphysema also involving lower lobes. Pulmonary embolism, cardiac or pulmonary shunt and immunopathologically based vasculitis were excluded. Pulmonary pressure was at the upper limit of normality but within few months he developed a severe pulmonary hypertension. Although spirometry is the only physiologic measure recommended by the updated Global Initiative for Chronic Obstructive Lung Disease guidelines for confirming the diagnosis it should be recognized that diffuse emphysema may occur with only abnormalities in gas exchange without airflow obstruction. The identification of different phenotypes within COPD is important for understanding disease heterogeneity and progression.

      PubDate: 2012-12-17T07:12:26Z
       
  • Pulmonary hydatid cyst embolization successfully treated with albendazole
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 4

      The location of echinococcal cysts inside pulmonary artery is extremely rare. We report a case of a 51-year-old patient with known surgical excision for hepatic hydatid cyst 14 years previously. He was admitted for a chest pain and haemoptysis. Angioscan showed multiple echinococcal cysts in both lungs and partial occlusion of a distal branches of the left pulmonary artery by hydatid cyst. CT scan of the abdomen revealed residual cavity in the liver. After medical therapy with albendazole, the patient was free of symptoms 12 months later.

      PubDate: 2012-12-17T07:12:26Z
       
  • Changing COPD definition
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 4



      PubDate: 2012-12-17T07:12:26Z
       
  • Unusual presentation of a complicated community-acquired pneumonia
           resembling lung cancer
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      We report a case of an unusual presentation of a complicated community-acquired pneumonia resembling lung cancer in an adult male with a long history of fever and consumption syndrome. Chest X-ray showed a right lower lobe consolidation and CT of the chest confirmed those findings. The bronchoscopy demonstrated a mass obstructing the right lower lobe orifice and narrowing the intermedius and right bronchus. Although the picture resembled a lung cancer, two biopsies were consistent with chronic inflammation and features of squamous metaplasia. He received several courses of empiric antibiotics (moxifloxacin and macrolides) without improvement. Cultures yielded Streptococcus pneumoniae and the antibiogram indicated exhibited resistance to moxifloxacin. We started with Amoxicilin–Clavulanic with a clear clinical and radiological improvement. This is the first case report in USA of a community-acquired pneumonia resistant to moxifloxacin.

      PubDate: 2012-12-17T07:12:26Z
       
  • Lipoid pneumonia showing multiple pulmonary nodules and reversed halo sign
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      We describe a 50-year-old man diagnosed with chronic exogenous lipoid pneumonia due to inhalation of paint spray. CT scan revealed multiple pulmonary nodules in both lungs. Resected specimens showed clusters of foamy macrophages in alveolar spaces, suggesting lipoid pneumonia. Long time inhalation of a small amount of paint oil may lead to lipoid pneumonia showing rare patterns such as multiple pulmonary nodules without surrounding parenchymal abnormal shadows. Five months later, some nodules increased still more in size, and some revealed reversed halo sign on CT. This case also suggests that reversed halo sign can be shown in lipoid pneumonia.

      PubDate: 2012-12-17T07:12:26Z
       
  • Resolution of subcutaneous emphysema with placement of subcutaneous
           fenestrated angiocatheter
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      Subcutaneous emphysema can occur idiopathically or as a consequence of invasive procedures. While it normally does not lead to any significant medical problems, it can add to patient discomfort. Other described techniques to treat subcutaneous emphysema have been ineffective or associated with complications. Successful utilization of a fenestrated subcutaneous angiocatheter for treatment of severe subcutaneous emphysema has been described in the literature. This case report serves as a literature review, as well as additional evidence to the efficacy of its use in the absence of complications.

      PubDate: 2012-12-17T07:12:26Z
       
  • A patient with chest pain and hemoptysis
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      Glomus tumours are distinctive neoplasms arising in the cells of the glomus body. Histologically they resemble modified smooth muscle cells. It usually occurs over the limbs. However, several unusual sites of occurrence have been described. These include the patella, chest wall, bone, heart, stomach, eyelid, lung, rectum, etc. Tracheal tumours have been described. We discuss a case of glomus tumour arising from the proximal trachea in a 43-year old male with complaints of intermittent hemoptysis and chest pain, and describe resection of this tumour using a rigid bronchoscopic technique. An overview of tracheal glomus tumours is presented.

      PubDate: 2012-12-17T07:12:26Z
       
  • Pleural cryptococcosis in AIDS—Unusual presentation
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      There are increasing reports of opportunistic cryptococcal infections with an ever expanding number of patients with acquired immune deficiency syndrome (AIDS). We report a case of a 50 years old male, who presented with history of prolonged fever and had pleural effusion which was positive for Cryptococcous neoformans. He was detected to be HIV positive and was treated with fluconazole. He showed significant resolution of signs and symptoms over 3 weeks and HAART was added with fluconazole

      PubDate: 2012-12-17T07:12:26Z
       
  • Lung nocardiosis in retroperitoneal fibrosis diagnosed by CT-guided fine
           needle aspiration
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      Computed tomography (CT)-guided fine needle aspiration (FNA) is a safe and effective procedure in the evaluation of undetermined pulmonary lesions. Most of the times FNA is a technique that leads to diagnosis in case of malignancies and benign tumors. Transthoracic FNA has a yield comparable to bronchoscopy for the diagnosis of infections and especially of rare opportunistic infections in immunosuppressed individuals. In this article we describe a case of Nocardia asteroides lung abscess that was diagnosed with CT-guided FNA, in a patient treated with corticosteroids for retroperitoneal fibrosis.

      PubDate: 2012-12-17T07:12:26Z
       
  • Neuroblastoma of the posterior mediastinum in a 61-year-old woman
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      Neuroblastoma is an embryonal tumour that evolves from the neural crest cell and rarely occurs in adults. Adult neuroblastoma is an uncommon malignancy that often pursues an aggressive clinical course, involves multiple sites, and has a poor prognosis. However, the prognosis of mediastinal neuroblastoma has been reported to be better than other neuroblastomas. We report a case of posterior mediastinal neuroblastoma differentiating type in a 61-year-old woman that was symptomatic and completely resected. Diagnosis was based on pathologic and immunohistochemical studies of the surgical specimen. Two years after the operation and without further treatment postoperatively, the patient showed no evidence of recurrence or metastasis.

      PubDate: 2012-12-17T07:12:26Z
       
  • Chemotherapy for small cell lung cancer in a patient with idiopathic
           thrombocytopenic purpura
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      Thrombocytopenia is one of the most important and serious co-morbid conditions in patients with hematological malignancies as well as non-hematological solid tumors. We report herein a small cell lung cancer (SCLC) patient with idiopathic thrombocytopenic purpura (ITP) who was successfully treated with chemotherapy containing cisplatin and etoposide. It is probably safe to administer chemotherapeutic agents for some cancer patients with ITP, but prevention or minimization of toxicities of these chemotherapeutic agents is very important. Full consideration about the indication of chemotherapy and careful observation are required for such patients.

      PubDate: 2012-12-17T07:12:26Z
       
  • Successful treatment of pulmonary mucormycosis with combined medical and
           surgical approach
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      Mucormycosis is an invasive opportunistic fungal infection that occurs frequently in diabetic patients with high rate of mortality. We report a new case of pulmonary mucormycosis in a 56-year-old woman with poorly controlled insulin dependent type II diabetes. Initial symptoms were recurrent haemoptysis with pulmonary infection unresponsive to broad-spectrum antibiotics. Bronchial biopsy showed hyphae with right-angle branching, typical of mucormycosis. Outcome was favourable after long-term amphotericin B and surgery. Although mucormycosis is rare, it should be considered in high-risk patients because early diagnosis and timely therapy combining antifungal drug, surgery and control of underlying disease appear to improve the prognosis.

      PubDate: 2012-12-17T07:12:26Z
       
  • Haemorrhagic pleural effusion secondary to inflammatory pseudotumor of
           spleen
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      A case of haemorrhagic pleural effusion secondary to inflammatory pseudotumor of spleen in a 47-year-old woman is reported. Clinical presentation was suggestive of malignant aetiology and the diagnosis was possible only with histological examination of resected spleen. At 36 months of follow-up after splenectomy, patient remained well and free from recurrence of pleural effusion. To our knowledge, no similar case has been reported so far.

      PubDate: 2012-12-17T07:12:26Z
       
  • Nemaline myopathy revealed by respiratory failure in adults
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      Most forms of myopathy may involve the respiratory muscles and progress to respiratory failure. However, the diagnosis of myopathy is seldom considered in an adult patient with no history of muscle disease and presenting with respiratory failure. Nemaline myopathy (NM) is a rare disorder characterized by symmetrical diffuse muscle weakness and rod-like nemaline bodies in muscle fibers. Respiratory muscle involvement is a major determinant of mortality in congenital NM, but is rare in late onset NM. Here, we report that acute or chronic respiratory failure may be caused by NM in subjects with no known history of muscle disease. Adult-onset NM was diagnosed in a 67-year-old woman with chronic respiratory insufficiency. Late onset childhood NM was revealed by respiratory failure in twin sisters aged 31. The diagnosis was established by muscle biopsy and electron microscopy (and mutations in the nebulin gene in the two sisters). Long-term clinical improvement was obtained with non-invasive ventilation (NIV) in the three patients. In conclusion, respiratory failure in an adult patient with no known history may correspond to NM with diaphragm involvement. Long-term outcome may be favorable with NIV.

      PubDate: 2012-12-17T07:12:26Z
       
  • Add-on sildenafil therapy for chronic thromboembolic pulmonary
           hypertension
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      The pulmonary hypertension that develops in chronic pulmonary thromboembolic diseases is caused by both mechanical obstruction of the vascular lumen and vascular remodeling, with pathological features similar to those of idiopathic pulmonary arterial hypertension (IPAH). The therapeutic efficacy of pulmonary thromboendarterectomy (PTE) in surgical candidates with chronic thromboembolic pulmonary hypertension (CTEPH) is well-established [Doyle RL, McCrory D, Channick RN, Simonneau G, Conte J. Surgical treatments/interventions for pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest 2004;126:63S–71S]. For CTEPH patients who are ineligible for PTE, therapeutic effects of various vasodilators in treatment of IPAH have been demonstrated. Although sildenafil, a phosphodiesterase type-5 inhibitor, has been reported to have short- and long-term benefits in terms of hemodynamics and functional status for inoperable CTEPH patients [Ghofrani HA, Schermuly RT, Rose F, Wiedemann R, Kohstall MG, et al. Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension. Am J Respir Crit Care Med 2003;167:1139–41; Sheth A, Park JE, Ong YE, Ho TB, Madden BP. Early haemodynamic benefit of sildenafil in patients with coexisting chronic thromboembolic pulmonary hypertension and left ventricular dysfunction. Vascul Pharmacol 2005;42:41–5], its role in CTEPH treatment for PTE candidates unwilling to undergo operation has not been explored specifically. We present the case of a 50-year-old female CTEPH patient who was a traditional candidate for PTE with poor clinical response to 3 months of anticoagulant therapy, where dramatic improvements were achieved after adding on 4 months of sildanefil treatment. Her treatment course is detailed, and we discuss the potential therapeutic effects of sildenafil for CTEPH.

      PubDate: 2012-12-17T07:12:26Z
       
  • Diagnosis of enigmatic chronic cough Neurovascular compression in a case
           of chronic cough progressively leading to compromised quality of life
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      Chronic cough is a clinical problem that can be linked to multiple disorders stemming from a variety of anatomical sites. Successful treatment depends on determination of the precise cause and initiation of specific therapy. Here we present the case history of a 33-year-old man with chronic cough due to multiple causes. Although the patient's most common complaints were treated, cough persisted. Long-term clinical follow-up led to a definitive diagnosis of a cranial nerve dysfunction syndrome, and cough resolved after successful specific treatment.

      PubDate: 2012-12-17T07:12:26Z
       
  • Non-allergy simple eosinophilic pneumonia—Löffler syndrome
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      The case of 53-year-old Caucasian woman was presented with 2-month history of low grade fever, shortness of breath, cough and reduced exercise tolerance irreversible to third generation cephalosporins as well as macrolide antimicrobial agents. The diagnosis of simple eosinophilic pneumonia (SEP) (Löffler's syndrome) was confirmed by transbronchial biopsy and by sternal testing. Biopsy specimen of the lung parenchyma showed changes associated with Löffler's syndrome. The diagnosis was, also, confirmed according to radiograph findings of unilateral migratory infiltrates consistent pneumonia. Treatment with corticosteroids resulted in a marked clinical improvement compared to non-corticosteroid therapy.

      PubDate: 2012-12-17T07:12:26Z
       
  • A case of bulla formation in usual interstitial pneumonia underlying
           dermatomyositis after a 5-year follow-up
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      We report a case of bulla formation in usual interstitial pneumonia (UIP) after a 5-year follow-up, proven by open lung biopsy, in a 35-year-old Korean man with dermatomyositis. Chest computed tomography showed marked bulla formation and bilateral hydrothorax. To our knowledge, the end result of UIP is honeycombing, respiratory failure, and infection. We postulate that if patients show good compliance in dealing with their UIP, the next form of honeycombing is bulla formation. This is the first report of bulla formation in UIP with dermatomyositis after long-term follow-up.

      PubDate: 2012-12-17T07:12:26Z
       
  • Co-existence of hepato-pulmonary syndrome and pulmonary hypertension in a
           patient with liver cirrhosis and intravenous drug abuse Review of
           literature and possible explanation
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      We describe a patient who had a history of cirrhosis and intravenous drug abuse. He had findings of the hepato-pulmonary syndrome and pulmonary hypertension. The co-existence of the hepato-pulmonary syndrome and pulmonary hypertension may be attributable to two separate processes: (a) cirrhosis causing pulmonary vascular dilatation at the pulmonary capillary level resulting in the hepato-pulmonary syndrome and (b) intravenous drug abuse causing narrowing of pulmonary vascular bed at the level of small pulmonary arteries, thereby, resulting in pulmonary hypertension with elevated pulmonary vascular resistance. However, the co-existence of the hepato-pulmonary syndrome and porto-pulmonary hypertension remains a distinct possibility.

      PubDate: 2012-12-17T07:12:26Z
       
  • Anti-oxidant and anti-inflammatory therapy in hypocomplementemic
           urticarial vasculitis with pulmonary emphysema
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      Background Hypocomplementemic urticarial vasculitis (HUV) with pulmonary emphysema is associated with a poor prognosis, despite high-dose anti-inflammatory treatment including steroids. Objective A female former marathon runner, age 47 years, was diagnosed with HUV with skin, renal and pulmonary involvement. Pulmonary arterial pressure was increased during exercise, a novel finding in this disease entity. Complement consumption was associated with the presence of an anti-C1q autoantibody (IgG). Methods The initial treatment included high-dose steroids and chloroquine. In analogy to other systemic inflammatory lung diseases, increased oxidant levels were postulated and high-dose acetylcysteine (NAC) was initiated. Later on, dapsone as an inhibitor of pathologically increased neutrophil function was added. Results Within 3 months, this therapy resulted in a significant increase of the reduced serum complement levels (CH50, APH50, C4A, and C4B), diffusing capacity, decrease of the anti-C1q autoantibody titer, and normalization of the increased granulocyte count in the broncho-alveolar lavage. Additionally, a stepwise improvement of exercise tolerance (6-min walk test, oxygen consumption during exercise) was seen. Dapsone had no further effect on diffusing capacity or (did not affect) complement serum levels, which remained slightly reduced but stable despite the presence of the anti-C1q autoantibody. The effects have remained stable for the following 36 months. The therapy was well tolerated. Conclusions Antioxidant therapy with high-dose NAC might be a potential addition to the conventional anti-inflammatory therapy in patients with HUV and pulmonary involvement. It should be considered for investigation in a larger patient population.

      PubDate: 2012-12-17T07:12:26Z
       
  • A disease that should be thought in the differential diagnosis of
           pneumonia: FMF
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      One of the diseases that is rarely thought in the differential diagnosis of pneumonia is Familial Mediterranean Fever (FMF). The 30-year-old female patient was admitted to our hospital with fever, cough, dyspnea and chest pain. The patient was hospitalized as group 3B pneumonia according to Turkish Thoracic Society Pneumonia Guideline, as this group of patients have both risk factors and modifying factors for community-acquired pneumonia and have to be treated in hospital without the need of intensive care unit. (It can be classified as class III according to Fine Scoring System.) Fever continued despite the antibiotherapy and there was not an origin of infection with our physical and radiological examinations; also no bacteria were found in the urine, blood and sputum cultures. When we investigated the fever of the patient, we have learnt that she had attacks of fever many times similarly, and when her fever occurred, she had chest and abdominal pain periodically. We started to think about FMF as the diagnosis and after genetic examinations, a mutation has been found in MEFV gene. The patient's diagnosis has been established as FMF. FMF should be thought in the differential diagnosis of pneumonia especially in Mediterranean society, like Turkey.

      PubDate: 2012-12-17T07:12:26Z
       
  • Inflammatory pseudotumor of the lungs
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      Inflammatory pseudotumor (IPT) of the lung is rare benign tumor which is in fact, nonneoplastic unregulated growth of inflammatory cells. Although plasma cells with reticuloendothelial elements are often seen, this kind of tumors is often described as a “plasma cell granuloma”. The lungs and airways are involved in the majority of cases, however, the mediastinum, thoracic lymph nodes and other structures are rarely affected (1). This benign entity of unknown origin is often locally invasive requiring extensive pulmonary resection (2). Because inflammatory pseudotumors mimic malignant tumors both clinically and radiologically, the radiologist should be familiar with this entity and help avoid unnecessary radical surgery when possible by including pseudotumor in the differential diagnosis (3). Radiographic findings as well as computed tomography are esential diagnostic procedures for malignancy distinction. Very slow growth, transformation to a sarcoma and regression (spontaneously or after corticosteroid therapy) have been described in the in clinical course of IPT (4).

      PubDate: 2012-12-17T07:12:26Z
       
  • Actinomyces odontolyticus as a rare cause of thoracoactinomycosis—A
           case report
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 3

      Actinomycosis, a bacterial infection in humans is most commonly caused by Actinomyces israelii. Less frequent causes include Actinomyces odontolyticus and Actinomyces viscosus. We present a rare case of thoracoactinomycosis caused by A. odontolyticus. It presented as a solitary pulmonary nodule, and formed neither draining sinuses nor granule formation, which is an unusual presentation. There are only nine cases of A. odontolyticus causing thoracoactinomycosis in the world literature, and this is the first such case reported from India.

      PubDate: 2012-12-17T07:12:26Z
       
  • A case of occupational asthma due to xylitol
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 2

      Xylitol has many uses, such as in dentistry and as a sweetening agent, and is synthesized from fungus by fermentation. According to some publications, xylitol has no adverse effects on the lungs in either healthy people or patients with cystic fibrosis, but no studies have examined the effects of long-term exposure. Here, we report a patient who developed occupational asthma due to xylitol as confirmed with provocation tests.

      PubDate: 2012-12-17T07:12:26Z
       
  • Mycoplasma pneumoniae causing familial infection and acute severe
           respiratory failure
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 2

      Mycoplasma pneumoniae usually causes only mild respiratory disease. Severe respiratory failure associated with bronchiolitis is extremely unusual. We describe an in-family spread of M. pneumoniae infection. The father, a 28-year-old smoker male with no previous medical history developed acute bronchiolitis with severe respiratory failure due to M. pneumoniae. He recovered after treatment with combination of antibiotics and corticosteroids. The patient's 55-year-old mother and 2-year-old daughter developed mycoplasma pneumonia, while his 25-year-old wife developed an upper respiratory tract infection. They were also treated successfully with macrolides.

      PubDate: 2012-12-17T07:12:26Z
       
  • Mycoplasma pneumoniae pneumonia presenting with febrile neutropenia
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 2

      A case of Mycoplasma pneumoniae pneumonia presenting with severe neutropenia, and diagnosed by immunoflourecence test is reported here. The patient was admitted to our clinic with severe neutropenia, and fever. During follow up a pneumonic consolidation was detected by thorax computerized tomography (CT) and anti-IgM was positive for M. pneumoniae serologically. It was concluded that neutropenia can develop due to M. pneumoniae.

      PubDate: 2012-12-17T07:12:26Z
       
  • Upper gastrointestinal bleeding as the initial manifestation of lung
           adenocarcinoma metastatic to the stomach
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 2

      Background Metastasis to the stomach rarely occurs, and gastric metastasis as an initial sign of cancer occurs even less frequently. We report herein a case of lung adenocarcinoma in which the patient's initial symptom was secondary to gastric metastasis. Case A 49-year-old woman was admitted to the hospital with complaints of melena, which had developed 3 days previously. Endoscopy revealed a gastric ulcer with bleeding. The endoscopic biopsy was consistent with adenocarcinoma. The initial clinical impression was gastric adenocarcinoma; however, a chest radiograph revealed right hilar enlargement. Bronchoscopic biopsy confirmed adenocarcinoma. Immunohistochemical studies in both specimens were positive for thyroid transcription factor-1 and thus suggestive of primary lung adenocarcinoma. The patient died 12 months after initial diagnosis. Conclusion Although the initial manifestation was unusual, clinicians should be aware that malignant gastric ulcers may represent as an initial sign of underlying lung adenocarcinoma and an immunohistochemical examination for thyroid transcription factor-1 should be obtained if metastatic gastric tumor from the lung is suspected. Optimal treatment rests on making an accurate diagnosis.

      PubDate: 2012-12-17T07:12:26Z
       
  • Postmenopausal progression of pulmonary lymphangioleiomyomatosis
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 2

      Though pulmonary lymphangioleiomyomatosis (LAM) is a rare disease that affects women in the reproductive years, there have been some reports in postmenopausal women, and even a few reports of pulmonary LAM in postmenopausal women without exogenous estrogen. This is the first report describing progression of pulmonary LAM after menopause. Physicians should be aware that pulmonary LAM could progress after menopause, although the course might run slower than that of LAM in the younger patients.

      PubDate: 2012-12-17T07:12:26Z
       
  • Acute lung injury after exposure to Stachybotrys chartarum
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 2

      An association between exposure to Stachybotrys chartarum, a ubiquitous environmental mold, and respiratory disease in humans has been suggested but remains poorly defined [Hossain MA, Ahmed MS, Ghannoum, MA. Attributes of Stachybotrys chartarum and its association with human disease. J Allergy Clin Immunol 2004; 113: 200–08]. We report a patient who presented with acute respiratory failure and histopathological evidence of diffuse alveolar damage shortly after exposure to S. chartarum in her home.

      PubDate: 2012-12-17T07:12:26Z
       
  • Rupture of bronchogenic cyst in the pericardium with high carbohydrate
           antigen 19-9 production
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 2

      Mediastinal bronchogenic cysts are frequently detected incidentally in adults. Here, we present a unique case of atypical clinical course of bronchogenic cyst beneath the carina, which ruptured into the pericardium. We could not diagnose definitely at initial admission, even though the massive pericardial fluid was exudative with high carbohydrate antigen (CA) 19-9 production. The fluid cytology was negative for malignancy. Five years later, the regrown and unruptured bronchogenic cyst caused atrial fibrillation by impinging on the heart with a high level of serum CA19-9. After resection of the CA19-9-enriched cyst by thoracoscopic surgery, he was discharged without recurrence of atrial fibrillation or any chest symptoms, and the serum CA19-9 level decreased to within the normal range. Differential diagnosis of cytology negative pericardial effusion with high CA19-9 production may be difficult, however, intrapericardial rupture of bronchogenic cyst should be considered in some patients.

      PubDate: 2012-12-17T07:12:26Z
       
  • A case with pulmonary tuberculosis, pleural effusion, miliary
           tuberculosis, cervical and mediastinal lymphadenopathy, tubercular
           arthritis, psoas abscess and severe anemia
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 2

      In this report, we describe an unusual case of disseminated tuberculosis (DTB) with pulmonary infiltrates, pleural effusion, miliary tuberculosis (MTB), cervical and mediastinal lymphadenopathy, tubercular arthritis, psoas abscess and severe anemia. Although the patient was immunocompetent, the disease had a gradual and unexpected progression. Tuberculosis can be present in multiple sites, especially in patients from areas where tuberculosis is endemic. An early diagnosis and prompt initiation of anti-tuberculosis treatment for appropriate duration ensures recovery even in complicated cases. In the malign forms of tuberculosis, treatment must be extended for a year or more. Response to anti-tuberculosis treatment was favorable in this case.

      PubDate: 2012-12-17T07:12:26Z
       
  • Lung cancer with spontaneous regression of scalp metastasis
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 2

      Spontaneous regression is partial or complete reduction of a malignant tumor without treatment or in the presence of therapy that is considered inadequate to exert a significant influence on neoplastic disease. We report herein a patient with lung cancer who had a spontaneous regression of scalp metastasis with no treatment performed. This is the first report of the spontaneous regression of scalp metastasis of lung cancer. The patient should be carefully followed up to chart his unusual clinical course.

      PubDate: 2012-12-17T07:12:26Z
       
  • Pulmonary Mucormycosis: Empiricism backfires
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 2

      A 35-year-old male was hospitalized with hypoxemic respiratory failure and newly diagnosed acute myelogenous leukemia. After initial improvement with chemotherapy and broad spectrum antibiotics, including antifungal therapy with voriconazole, a new right upper lobe pulmonary 1.6cm nodule was discovered during workup for persistent fever. Respiratory failure recurred and repeat CT revealed that the nodule had become a necrotic mass involving the right upper lobe, chest wall, and mediastinum, which biopsy showed to be mucormycosis. Therapy was changed to amphotericin, but the patient died. As this case demonstrates, optimal management of patients with suspected invasive fungal disease mandates a vigorous diagnostic evaluation, especially in the face of new or evolving radiographic findings. Antifungal therapies are not equal in their ability to treat non-aspergillus molds, and as such may not address the responsible pathogen. The potential downside of empiricism and diagnostic delay is demonstrated here.

      PubDate: 2012-12-17T07:12:26Z
       
  • Thoracic empyema due to Salmonella enteritidis infection in a patient with
           breast cancer
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 2

      We report a rare case of thoracic empyema due to Salmonella enteritidis infection in a 79-year-old woman with breast cancer and diarrhea. The presence of the bacteria was determined by culturing the stool, blood, and pleural fluid. Although it is a rare occurrence, Salmonella empyema should be excluded in a febrile cancer patient with pleural effusion and a recent history of enteritis.

      PubDate: 2012-12-17T07:12:26Z
       
  • Mycobacterium fortuitum infection and lipoid pneumonia
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 2

      We report the case of a non-immunocompromised male patient, who developed exogenous lipoid pneumonia complicated with Mycobacterium fortuitum infection. The association of exogenous lipoid pneumonia with atypical mycobacterial infection is uncommon but well-recognized.

      PubDate: 2012-12-17T07:12:26Z
       
  • Simultaneous adenocarcinoma and squamous cell carcinoma arising from a
           mediastinal cystic teratoma: Case report and literature review
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 1

      Teratoma with malignant transformation is rarely seen in gonadal or extra-gonadal sites. Extra-gonadal teratoma with malignant transformation is usually found in the mediastinum. More than two-thirds of mediastinal teratoma with malignant transformation cases receive chemotherapy or irradiation at the time of diagnosis. Herein, we report a naturally occurring mediastinal teratoma with malignant transformation in a 43-year-old man complaining of chest tightness and severe dyspnea. A huge cystic mediastinal mass was discovered from chest-computerized tomography scan. Emergent thoracostomy was performed to remove the tumor because of impending respiratory failure. The histology of the tumor was compatible with cystic teratoma, and the transformed non-germ cell region showed both adenocarcinoma and squamous cell carcinoma. The patient underwent postoperative chemotherapy. However, his condition deteriorated rapidly and he expired 8 months after diagnosis. Summarizing previous case reports in the literature: (1) 34.6% of mediastinal teratoma with malignant transformation patients survive after treatment; (2) the malignant components are sarcoma and carcinoma; similar survival rates are achieved where both histological features are present, however, survival is reduced with multiple or mixed types of malignant transformation; (3) the delineation between treatment-induced and naturally occurring teratoma with malignant transformation at the mediastinal site is indistinct; and, (4) complete surgical eradication is still the mainstay of treatment for prolonged survival in patients with mediastinal teratoma with malignant transformation.

      PubDate: 2012-12-17T07:12:26Z
       
  • Spontaneous regression of a primary sarcoma of the pulmonary artery
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 1

      We report a case of spontaneous regression of a pulmonary sarcoma. A 76-year-old-woman was found to have a mass arising from the left pulmonary artery and extending into the left lung. Seven months later, the mass of the left lung lesion had shrunk without treatment, but metastases appeared in the left lung. Sarcoma was diagnosed with histological examination of tissue from the pulmonary metastases. The patient died after metastases appeared in the brain 22 months after presentation.

      PubDate: 2012-12-17T07:12:26Z
       
  • Pitfalls in diagnosis of pulmonary histoplasmosis
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 1

      Many diagnoses are missed or delayed because pulmonary histoplasmosis is not considered. Therefore, recognition of its different clinical manifestations and differential diagnoses, accompanied by knowledge of the accuracy and limitations of tests for this condition, is essential. Three cases are reported and diagnostic pitfalls are discussed.

      PubDate: 2012-12-17T07:12:26Z
       
  • Pneumonia associated with Bordetella pertussis infection in a 16-year-old
           boy
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 1

      Bordetella pertussis infection is often regarded by clinicians as a childhood illness, and the diagnosis may not be considered when adults present with respiratory symptoms. However, there is evidence that B. pertussis infection is considerably underdiagnosed in adults, who are susceptible as a result of waning immunity, and in whom the presentation may not be typical. Here, a case of an adolescent who was admitted to hospital with pneumonia due to B. pertussis infection is presented. Aspects of clinical presentation, diagnosis and epidemiology are discussed.

      PubDate: 2012-12-17T07:12:26Z
       
  • The etiology of nonspecific interstitial pneumonitis in acquired
           immunodeficiency syndrome
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 1

      Interstitial pneumonitis without evidence of Pneumocystis jiroveci infection has been described in the patients infected with immunodeficiency virus (HIV). Nonspecific interstitial pneumonitis (NSIP) is the most commonly observed pathologic diagnosis. The etiology of NSIP in HIV infected patients is unknown. We retrospectively studied 6 cases of NSIP that were diagnosed with transbronchial biopsies. The etiologic causes of NSIP were evaluated retrospectively by reviewing the inpatient and outpatient charts. The medical records from other institutions were also reviewed when available. We concluded that cocaine abuse, disseminated Mycobacterium avium complex infection, cytomegalovirus (CMV) pneumonitis, and immune reconstitution syndrome were the potential causes of NSIP in our patients with HIV infection.

      PubDate: 2012-12-17T07:12:26Z
       
  • Isolated tracheal papillomatosis—An infrequent cause of chronic
           cough
    • Abstract: 2007
      Publication year: 2007
      Source:Respiratory Medicine Extra, Volume 3, Issue 1

      We present the case of a 15yr-old male who was referred to the respiratory department for investigation of a chronic cough that was severely affecting his daily activities. He had previously been diagnosed with “psychogenic cough” in another institution. A bronchoscopy was performed which revealed mucosal abnormality on the posterior wall of the trachea. Biopsies of these lesions were suggestive of a viral aetiology and subsequent PCR analysis of the tracheal biopsy detected human papilloma virus (HPV) DNA subtypes 11 and 16. HPV isolated to the trachea without evidence of more proximal involvement is rare. In our discussion, we present the aetiology, risk factors, treatment and complications of this condition. This case highlights the importance of a complete assessment of cough in all cases as recently described in the American College of Chest Physicians’ guidelines on the diagnosis and management of cough.

      PubDate: 2012-12-17T07:12:26Z
       
 
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