Subjects -> MEDICAL SCIENCES (Total: 8359 journals)
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CARDIOVASCULAR DISEASES (329 journals)                  1 2 | Last

Showing 1 - 200 of 329 Journals sorted alphabetically
Acta Angiologica     Open Access   (Followers: 5)
Acta Cardiologica     Hybrid Journal   (Followers: 2)
Acute Cardiac Care     Hybrid Journal   (Followers: 7)
Adipositas - Ursachen, Folgeerkrankungen, Therapie     Hybrid Journal  
AJP Heart and Circulatory Physiology     Hybrid Journal   (Followers: 12)
Aktuelle Kardiologie     Hybrid Journal   (Followers: 1)
American Heart Journal     Hybrid Journal   (Followers: 58)
American Journal of Cardiology     Hybrid Journal   (Followers: 67)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 17)
American Journal of Hypertension     Hybrid Journal   (Followers: 28)
Anales de Cirugia Vascular     Full-text available via subscription   (Followers: 1)
Anatolian Journal of Cardiology     Open Access   (Followers: 6)
Angiología     Full-text available via subscription  
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1)
Angiology     Hybrid Journal   (Followers: 3)
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (Followers: 1)
Annals of Noninvasive Electrocardiology     Hybrid Journal   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 12)
AORTA     Open Access  
Archives of Cardiovascular Diseases     Full-text available via subscription   (Followers: 5)
Archives of Cardiovascular Diseases Supplements     Full-text available via subscription   (Followers: 3)
Archives of Cardiovascular Imaging     Open Access   (Followers: 2)
Archivos de cardiología de México     Open Access   (Followers: 1)
Argentine Journal of Cardiology (English edition)     Open Access   (Followers: 2)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 1)
Arteriosclerosis, Thrombosis and Vascular Biology     Full-text available via subscription   (Followers: 32)
Artery Research     Hybrid Journal   (Followers: 4)
ARYA Atherosclerosis     Open Access  
ASAIO Journal     Hybrid Journal   (Followers: 3)
ASEAN Heart Journal     Open Access   (Followers: 2)
Asian Cardiovascular and Thoracic Annals     Hybrid Journal   (Followers: 2)
Aswan Heart Centre Science & Practice Services     Open Access   (Followers: 1)
Atherosclerosis : X     Open Access  
Bangladesh Heart Journal     Open Access   (Followers: 3)
Basic Research in Cardiology     Hybrid Journal   (Followers: 10)
BMC Cardiovascular Disorders     Open Access   (Followers: 22)
Brain Circulation     Open Access   (Followers: 1)
British Journal of Cardiology     Full-text available via subscription   (Followers: 16)
Canadian Journal of Cardiology     Hybrid Journal   (Followers: 18)
Cardiac Cath Lab Director     Full-text available via subscription  
Cardiac Electrophysiology Review     Hybrid Journal   (Followers: 2)
Cardiocore     Full-text available via subscription   (Followers: 1)
Cardiogenetics     Open Access   (Followers: 3)
Cardiology     Full-text available via subscription   (Followers: 20)
Cardiology and Angiology: An International Journal     Open Access   (Followers: 1)
Cardiology and Therapy     Open Access   (Followers: 12)
Cardiology Clinics     Full-text available via subscription   (Followers: 14)
Cardiology in Review     Hybrid Journal   (Followers: 8)
Cardiology in the Young     Hybrid Journal   (Followers: 34)
Cardiology Journal     Open Access   (Followers: 6)
Cardiology Plus     Open Access   (Followers: 1)
Cardiology Research     Open Access   (Followers: 15)
Cardiology Research and Practice     Open Access   (Followers: 10)
Cardiopulmonary Physical Therapy Journal     Hybrid Journal   (Followers: 7)
Cardiorenal Medicine     Full-text available via subscription   (Followers: 1)
Cardiothoracic Surgeon     Open Access   (Followers: 1)
CardioVasc     Full-text available via subscription   (Followers: 1)
Cardiovascular & Haematological Disorders - Drug Targets     Hybrid Journal   (Followers: 1)
Cardiovascular & Hematological Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 2)
CardioVascular and Interventional Radiology     Hybrid Journal   (Followers: 15)
Cardiovascular and Thoracic Open     Open Access  
Cardiovascular Diabetology     Open Access   (Followers: 10)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 14)
Cardiovascular Endocrinology & Metabolism     Hybrid Journal   (Followers: 1)
Cardiovascular Engineering     Hybrid Journal   (Followers: 1)
Cardiovascular Engineering and Technology     Hybrid Journal   (Followers: 1)
Cardiovascular Intervention and Therapeutics     Hybrid Journal   (Followers: 5)
Cardiovascular Journal     Open Access   (Followers: 6)
Cardiovascular Journal of Africa     Full-text available via subscription   (Followers: 5)
Cardiovascular Journal of South Africa     Full-text available via subscription   (Followers: 1)
Cardiovascular Medicine in General Practice     Full-text available via subscription   (Followers: 7)
Cardiovascular Pathology     Hybrid Journal   (Followers: 4)
Cardiovascular Regenerative Medicine     Open Access  
Cardiovascular Research     Hybrid Journal   (Followers: 15)
Cardiovascular Revascularization Medicine     Hybrid Journal   (Followers: 1)
Cardiovascular System     Open Access  
Cardiovascular Therapeutics     Open Access   (Followers: 1)
Cardiovascular Toxicology     Hybrid Journal   (Followers: 6)
Cardiovascular Ultrasound     Open Access   (Followers: 5)
Case Reports in Cardiology     Open Access   (Followers: 7)
Catheterization and Cardiovascular Interventions     Hybrid Journal   (Followers: 3)
Cerebrovascular Diseases     Full-text available via subscription   (Followers: 3)
Cerebrovascular Diseases Extra     Open Access  
Chest     Full-text available via subscription   (Followers: 100)
Choroby Serca i Naczyń     Open Access   (Followers: 1)
Circulation     Hybrid Journal   (Followers: 247)
Circulation : Cardiovascular Imaging     Hybrid Journal   (Followers: 15)
Circulation : Cardiovascular Interventions     Hybrid Journal   (Followers: 17)
Circulation : Cardiovascular Quality and Outcomes     Hybrid Journal   (Followers: 11)
Circulation : Genomic and Precision Medicine     Hybrid Journal   (Followers: 15)
Circulation : Heart Failure     Hybrid Journal   (Followers: 26)
Circulation Research     Hybrid Journal   (Followers: 36)
Cirugía Cardiovascular     Open Access  
Clínica e Investigación en Arteriosclerosis     Full-text available via subscription  
Clínica e Investigación en arteriosclerosis (English Edition)     Hybrid Journal  
Clinical and Experimental Hypertension     Hybrid Journal   (Followers: 3)
Clinical Cardiology     Hybrid Journal   (Followers: 11)
Clinical Hypertension     Open Access   (Followers: 5)
Clinical Medicine Insights : Cardiology     Open Access   (Followers: 6)
Clinical Research in Cardiology     Hybrid Journal   (Followers: 6)
Clinical Research in Cardiology Supplements     Hybrid Journal  
Clinical Trials and Regulatory Science in Cardiology     Open Access   (Followers: 4)
Congenital Heart Disease     Hybrid Journal   (Followers: 6)
Congestive Heart Failure     Hybrid Journal   (Followers: 4)
Cor et Vasa     Full-text available via subscription   (Followers: 1)
Coronary Artery Disease     Hybrid Journal   (Followers: 2)
CorSalud     Open Access  
Critical Pathways in Cardiology     Hybrid Journal   (Followers: 4)
Current Cardiology Reports     Hybrid Journal   (Followers: 7)
Current Cardiology Reviews     Hybrid Journal   (Followers: 4)
Current Cardiovascular Imaging Reports     Hybrid Journal   (Followers: 1)
Current Cardiovascular Risk Reports     Hybrid Journal  
Current Heart Failure Reports     Hybrid Journal   (Followers: 5)
Current Hypertension Reports     Hybrid Journal   (Followers: 6)
Current Hypertension Reviews     Hybrid Journal   (Followers: 6)
Current Opinion in Cardiology     Hybrid Journal   (Followers: 14)
Current Problems in Cardiology     Hybrid Journal   (Followers: 3)
Current Research : Cardiology     Full-text available via subscription   (Followers: 1)
Current Treatment Options in Cardiovascular Medicine     Hybrid Journal   (Followers: 1)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 5)
CVIR Endovascular     Open Access   (Followers: 1)
Der Kardiologe     Hybrid Journal   (Followers: 2)
Echo Research and Practice     Open Access   (Followers: 2)
Echocardiography     Hybrid Journal   (Followers: 4)
Egyptian Heart Journal     Open Access   (Followers: 2)
Egyptian Journal of Cardiothoracic Anesthesia     Open Access  
ESC Heart Failure     Open Access   (Followers: 4)
European Heart Journal     Hybrid Journal   (Followers: 67)
European Heart Journal - Cardiovascular Imaging     Hybrid Journal   (Followers: 10)
European Heart Journal - Cardiovascular Pharmacotherapy     Full-text available via subscription   (Followers: 3)
European Heart Journal - Quality of Care and Clinical Outcomes     Hybrid Journal  
European Heart Journal : Acute Cardiovascular Care     Hybrid Journal   (Followers: 1)
European Heart Journal : Case Reports     Open Access   (Followers: 1)
European Heart Journal Supplements     Hybrid Journal   (Followers: 8)
European Journal of Cardio-Thoracic Surgery     Hybrid Journal   (Followers: 9)
European Journal of Cardio-Thoracic Surgery Supplements     Full-text available via subscription   (Followers: 2)
European Journal of Cardiovascular Nursing     Hybrid Journal   (Followers: 5)
European Journal of Heart Failure     Hybrid Journal   (Followers: 14)
European Journal of Preventive Cardiology.     Hybrid Journal   (Followers: 6)
European Stroke Organisation     Hybrid Journal   (Followers: 3)
Experimental & Translational Stroke Medicine     Open Access   (Followers: 8)
Expert Review of Cardiovascular Therapy     Full-text available via subscription   (Followers: 3)
Folia Cardiologica     Open Access  
Forum Zaburzeń Metabolicznych     Hybrid Journal  
Frontiers in Cardiovascular Medicine     Open Access   (Followers: 1)
Future Cardiology     Hybrid Journal   (Followers: 6)
General Thoracic and Cardiovascular Surgery     Hybrid Journal   (Followers: 3)
Global Cardiology Science and Practice     Open Access   (Followers: 5)
Global Heart     Hybrid Journal   (Followers: 3)
Heart     Hybrid Journal   (Followers: 48)
Heart and Mind     Open Access  
Heart and Vessels     Hybrid Journal  
Heart Failure Clinics     Full-text available via subscription   (Followers: 2)
Heart Failure Reviews     Hybrid Journal   (Followers: 3)
Heart India     Open Access   (Followers: 2)
Heart International     Full-text available via subscription  
Heart Rhythm     Hybrid Journal   (Followers: 11)
Heart Views     Open Access   (Followers: 2)
HeartRhythm Case Reports     Open Access  
Hellenic Journal of Cardiology     Open Access   (Followers: 1)
Herz     Hybrid Journal   (Followers: 3)
High Blood Pressure & Cardiovascular Prevention     Full-text available via subscription   (Followers: 2)
Hypertension     Full-text available via subscription   (Followers: 23)
Hypertension in Pregnancy     Hybrid Journal   (Followers: 9)
Hypertension Research     Hybrid Journal   (Followers: 5)
Ibrahim Cardiac Medical Journal     Open Access  
IJC Heart & Vessels     Open Access   (Followers: 1)
IJC Heart & Vasculature     Open Access   (Followers: 1)
IJC Metabolic & Endocrine     Open Access   (Followers: 1)
Indian Heart Journal     Open Access   (Followers: 5)
Indian Journal of Cardiovascular Disease in Women WINCARS     Open Access  
Indian Journal of Thoracic and Cardiovascular Surgery     Hybrid Journal  
Indian Pacing and Electrophysiology Journal     Open Access   (Followers: 1)
Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery     Hybrid Journal   (Followers: 1)
Insuficiencia Cardíaca     Open Access  
Interactive CardioVascular and Thoracic Surgery     Hybrid Journal   (Followers: 7)
International Cardiovascular Forum Journal     Open Access  
International Journal of Angiology     Hybrid Journal   (Followers: 2)
International Journal of Cardiology     Hybrid Journal   (Followers: 18)
International Journal of Cardiovascular and Cerebrovascular Disease     Open Access   (Followers: 2)
International Journal of Cardiovascular Imaging     Hybrid Journal   (Followers: 2)
International Journal of Cardiovascular Research     Hybrid Journal   (Followers: 6)
International Journal of Heart Rhythm     Open Access  
International Journal of Hypertension     Open Access   (Followers: 8)
International Journal of Hyperthermia     Open Access  
International Journal of Stroke     Hybrid Journal   (Followers: 30)
International Journal of the Cardiovascular Academy     Open Access  
Interventional Cardiology Clinics     Full-text available via subscription   (Followers: 2)
Interventional Cardiology Review     Full-text available via subscription  
JACC : Basic to Translational Science     Open Access   (Followers: 5)
JACC : Cardiovascular Imaging     Hybrid Journal   (Followers: 18)
JACC : Cardiovascular Interventions     Hybrid Journal   (Followers: 17)
JACC : Heart Failure     Full-text available via subscription   (Followers: 14)
JAMA Cardiology     Hybrid Journal   (Followers: 28)
JMIR Cardio     Open Access  
Jornal Vascular Brasileiro     Open Access  
Journal of Clinical & Experimental Cardiology     Open Access   (Followers: 5)
Journal of Arrhythmia     Open Access  
Journal of Cardiac Critical Care TSS     Open Access   (Followers: 1)
Journal of Cardiac Failure     Hybrid Journal   (Followers: 1)

        1 2 | Last

Similar Journals
Journal Cover
JACC : Basic to Translational Science
Journal Prestige (SJR): 1.529
Citation Impact (citeScore): 2
Number of Followers: 5  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2452-302X
Published by Elsevier Homepage  [3147 journals]
  • Reduced Left Atrial Emptying Fraction and Chymase Activation in
           Pathophysiology of Primary Mitral Regurgitation

    • Abstract: Publication date: Available online 22 January 2020Source: JACC: Basic to Translational ScienceAuthor(s): Brittany Butts, Mustafa I. Ahmed, Navkaranbir S. Bajaj, Pamela Cox Powell, Betty Pat, Silvio Litovsky, Himanshu Gupta, Steven G. Lloyd, Thomas S. Denney, Xiaoxia Zhang, Inmaculada Aban, Sakthivel Sadayappan, James W. McNamara, Michael J. Watson, Carlos M. Ferrario, James F. Collawn, Clifton Lewis, James E. Davies, Louis J. Dell’ItaliaSummaryIncreasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in addition to having a potential intracellular role in mediating myofibrillar breakdown in LA myocytes. Because of the unreliability of the left ventricular ejection fraction in predicting outcomes in MR, LA size and the total LA emptying fraction may be more suitable indicators for timing of surgical intervention.Visual Graphical abstract for this article
       
  • Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis
           and Hypertrophy in Uremic Cardiomyopathy

    • Abstract: Publication date: Available online 15 January 2020Source: JACC: Basic to Translational ScienceAuthor(s): Bin Wang, Ze-Mu Wang, Jia-Ling Ji, Weihua Gan, Aiqing Zhang, Hao-Jie Shi, Hao Wang, Linli Lv, Zuolin Li, Taotao Tang, Jie Du, Xiaonan H. Wang, Bi-Cheng LiuSummarymiR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages in a uremic heart. The released exosomal fusion with the plasma membrane leads to the release of miR-155 into the cytosol and translational repression of forkhead transcription factors of the O class (FoxO3a) in cardiomyocytes. Finally, macrophage-derived miR-155–containing exosomes promoted cardiomyocyte pyroptosis and uremic cardiomyopathy changes (cardiac hypertrophy and fibrosis) by directly targeting FoxO3a in uremic mice.Visual Graphical abstract for this article
       
  • Genetic Deletion of Socs3 in Smooth Muscle Cells Ameliorates Aortic
           Dissection in Mice

    • Abstract: Publication date: Available online 8 January 2020Source: JACC: Basic to Translational ScienceAuthor(s): Saki Hirakata, Hiroki Aoki, Satoko Ohno-Urabe, Michihide Nishihara, Aya Furusho, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Hideo Yasukawa, Tsutomu Imaizumi, Sinichi Hiromatsu, Hiroyuki Tanaka, Yoshihiro FukumotoSummaryAortic dissection (AD) is the acute destruction of aortic wall and is reportedly induced by inflammatory response. Here we investigated the role of smooth muscle Socs3 (a negative regulator of Janus kinases/signal transducer and activator of transcription signaling) in AD pathogenesis using a mouse model generated via β-aminopropionitrile and angiotensin II infusion. Socs3 deletion specifically in smooth muscle cells yielded a chronic inflammatory response of the aortic wall, which was associated with increased fibroblasts, reinforced aortic tensile strength, and less-severe tissue destruction. Although an acute inflammatory response is detrimental in AD, smooth muscle-regulated inflammatory response seemed protective against AD.Visual Graphical abstract for this article
       
  • Sonodynamic Therapy Suppresses Neovascularization in Atherosclerotic
           Plaques via Macrophage Apoptosis-Induced Endothelial Cell Apoptosis

    • Abstract: Publication date: Available online 26 December 2019Source: JACC: Basic to Translational ScienceAuthor(s): Jianting Yao, Weiwei Gao, Yu Wang, Lu Wang, Kamal Diabakte, Jinyang Li, Jiemei Yang, Yongxing Jiang, Yuerong Liu, Shuyuan Guo, Xuezhu Zhao, Zhengyu Cao, Xi Chen, Qiannan Li, Haiyu Zhang, Wei Wang, Zhen Tian, Bicheng Li, Fang Tian, Guodong WuSummaryDuring atherosclerosis plaque progression, pathological intraplaque angiogenesis leads to plaque rupture accompanied by thrombosis, which is probably the most important cause of arteries complications such as cerebral and myocardial infarction. Even though few treatments are available to mitigate plaque rupture, further investigation is required to develop a robust optimized therapeutic method. In this study using rabbit and mouse atherosclerotic models, sinoporphyrin sodium (DVDMS)-mediated sonodynamic therapy reduced abnormal angiogenesis and plaque rupture. Briefly, DVDMS is injected to animals, and then the plaque was locally exposed to pulse ultrasound for a few minutes. Furthermore, a small size clinical trial was conducted on patients with atherosclerosis. Notably, a significant reduction of arterial inflammation and angiogenesis was recorded following a short period of DVDMS-mediated sonodynamic therapy treatment. This beneficial outcome was almost equivalent to the therapeutic outcome after 3-month intensive statin treatment.Visual Graphical abstract for this article
       
  • Celastrol Alleviates Aortic Valve Calcification Via Inhibition of NADPH
           Oxidase 2 in Valvular Interstitial Cells

    • Abstract: Publication date: Available online 18 December 2019Source: JACC: Basic to Translational ScienceAuthor(s): Huibing Liu, Libo Wang, Yating Pan, Xuehui Wang, Yuan Ding, Chaoyuan Zhou, Ajay M. Shah, Guoan Zhao, Min ZhangSummaryThe study sought to investigate whether reactive oxygen species (ROS)–generating reduced nicotinamide adenine dinucleotide phosphate oxidase 2 (Nox2) contributes to calcific aortic valve disease (CAVD) or whether celastrol, a natural Nox2 inhibitor, may provide potential therapeutic target for CAVD. CAVD is an active and cellular-driven fibrocalcific process characterized by differentiation of aortic valvular interstitial cells (AVICs) toward an osteogenic-like phenotype. ROS levels increase in calcified aortic valves, while the sources of ROS and their roles in the pathogenesis of CAVD are elusive. The roles of Nox2 and the effects of celastrol were studied using cultured porcine AVICs in vitro and a rabbit CAVD model in vivo. Nox2 proteins were significantly upregulated in human aortic valves with CAVD. In vitro, Nox2 was markedly induced upon stimulation of AVICs with osteogenic medium, along with the increases in ROS production and calcium nodule formation. Celastrol significantly decreased calcium deposition of AVICs by 35%, with a reduction of ROS generation. Knockdown of endogenous Nox2 substantially suppressed AVIC calcification by 39%, the inhibitory effect being similar to celastrol treatment. Mechanistically, either celastrol treatment or knockdown of Nox2 significantly inhibited glycogen synthase kinase 3 beta/β-catenin signaling, leading to attenuation of fibrogenic and osteogenic responses of AVICs. In a rabbit CAVD model, administration of celastrol significantly reduced aortic valve ROS production, fibrosis, calcification, and severity of aortic stenosis, with less left ventricular dilatation and better preserved contractile function. Upregulation of Nox2 is critically involved in CAVD. Celastrol is effective to alleviate CAVD, likely through the inhibition of Nox2-mediated glycogen synthase kinase 3 beta/β-catenin pathway in AVICs.Visual Graphical abstract for this article
       
  • Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus
           Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements

    • Abstract: Publication date: Available online 11 December 2019Source: JACC: Basic to Translational ScienceAuthor(s): Emanuela S. Fioretta, Valentina Lintas, Anna Mallone, Sarah E. Motta, Lisa von Boehmer, Petra E. Dijkman, Nikola Cesarovic, Etem Caliskan, Héctor Rodriguez Cetina Biefer, Miriam Lipiski, Mareike Sauer, Matilde Putti, Henk M. Janssen, Serge H. Söntjens, Anthal I.P.M. Smits, Carlijn V.C. Bouten, Maximilian Y. Emmert, Simon P. HoerstrupSummaryThis study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell–scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach.Visual Graphical abstract for this article
       
  • Cardiac Versus Renal Response to Volume Expansion in Preclinical Systolic
           Dysfunction With PDEV Inhibition and BNP

    • Abstract: Publication date: December 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 8Author(s): Siu-Hin Wan, Isabel Torres-Courchoud, Paul M. McKie, Joshua P. Slusser, Margaret M. Redfield, John C. Burnett, David O. Hodge, Horng H. ChenSummaryImpaired cardiorenal response to acute saline volume expansion in preclinical systolic dysfunction (PSD) may lead to symptomatic heart failure. The objective was to determine if combination phosphodiesterase-V inhibition and exogenous B-type natriuretic peptide (BNP) administration may enhance cardiorenal response. A randomized double-blinded, placebo-controlled study was conducted in 21 subjects with PSD and renal dysfunction. Pre-treatment with tadalafil and subcutaneous BNP resulted in improved cardiac function, as evidenced by improvement in ejection fraction, left atrial volume index, and left ventricular end-diastolic volume. However, there was reduced renal response with reduction in renal plasma flow, glomerular filtration rate, and urine flow. (Tadalafil and Nesiritide as Therapy in Pre-clinical Heart Failure; NCT01544998)Visual Graphical abstract for this article
       
  • &rft.title=JACC+:+Basic+to+Translational+Science&rft.issn=2452-302X&rft.date=&rft.volume=">Targeting Muscles in the Brain to Enhance Cerebral Perfusion ∗

    • Abstract: Publication date: December 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 8Author(s): Jin-Moo Lee, Abhinav Diwan, Gregory J. ZipfelCorresponding AuthorGraphical abstract for this article
       
  • &rft.title=JACC+:+Basic+to+Translational+Science&rft.issn=2452-302X&rft.date=&rft.volume=">The Bslc2 –/– Mouse: Adding a Missing Phenotype to the Repertoire of
           HFpEF Animal Models ∗

    • Abstract: Publication date: December 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 8Author(s): Fadi N. Salloum, Stefano ToldoCorresponding AuthorGraphical abstract for this article
       
  • ∗&rft.title=JACC+:+Basic+to+Translational+Science&rft.issn=2452-302X&rft.date=&rft.volume=">Therapeutic Treatment Approaches Post–Myocardial Infarction: A Bias
           Toward Formyl Peptide Receptor Agonists∗

    • Abstract: Publication date: December 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 8Author(s): Rysa Zaman, Slava EpelmanGraphical abstractFirst AuthorGraphical abstract for this articleCorresponding AuthorGraphical abstract for this article
       
  • Epigenetics in Cardiac Hypertrophy and Heart Failure

    • Abstract: Publication date: December 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 8Author(s): Chia-Feng Liu, W.H. Wilson TangSummaryHeart failure (HF) is a complex syndrome affecting millions of people around the world. Over the past decade, the therapeutic potential of targeting epigenetic regulators in HF has been discussed extensively. Recent advances in next-generation sequencing techniques have contributed substantial progress in our understanding of the role of DNA methylation, post-translational modifications of histones, adenosine triphosphate (ATP)-dependent chromatin conformation and remodeling, and non-coding RNAs in HF pathophysiology. In this review, we summarize epigenomic studies on human and animal models in HF.Central IllustrationGraphical abstract for this article
       
  • &rft.title=JACC+:+Basic+to+Translational+Science&rft.issn=2452-302X&rft.date=&rft.volume=">Interleukin 5 Contributes to Human Atherosclerosis Development But not to
           Thrombotic Complications ∗

    • Abstract: Publication date: December 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 8Author(s): Hafid Ait-Oufella, Soraya Taleb, Alain TedguiCorresponding AuthorGraphical abstract for this article
       
  • &rft.title=JACC+:+Basic+to+Translational+Science&rft.issn=2452-302X&rft.date=&rft.volume=">The New Promise of Mitochondrial Transplantation for Myocardial
           Recovery ∗

    • Abstract: Publication date: December 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 8Author(s): W.H. Wilson TangCorresponding AuthorGraphical abstract for this article
       
  • A Novel Biological Strategy for Myocardial Protection by Intracoronary
           Delivery of Mitochondria: Safety and Efficacy

    • Abstract: Publication date: December 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 8Author(s): Borami Shin, Mossab Y. Saeed, Jesse J. Esch, Alvise Guariento, David Blitzer, Kamila Moskowitzova, Giovanna Ramirez-Barbieri, Arzoo Orfany, Jerusha K. Thedsanamoorthy, Douglas B. Cowan, James A. Inkster, Erin R. Snay, Steven J. Staffa, Alan B. Packard, David Zurakowski, Pedro J. del Nido, James D. McCullySummaryMitochondrial dysfunction is the determinant insult of ischemia-reperfusion injury. Autologous mitochondrial transplantation involves supplying one’s healthy mitochondria to the ischemic region harboring damaged mitochondria. The authors used in vivo swine to show that mitochondrial transplantation in the heart by intracoronary delivery is safe, with specific distribution to the heart, and results in significant increase in coronary blood flow, which requires intact mitochondrial viability, adenosine triphosphate production, and, in part, the activation of vascular KIR channels. Intracoronary mitochondrial delivery after temporary regional ischemia significantly improved myocardial function, perfusion, and infarct size. The authors concluded that intracoronary delivery of mitochondria is safe and efficacious therapy for myocardial ischemia-reperfusion injury.Visual Graphical abstract for this article
       
  • Full Issue PDF

    • Abstract: Publication date: December 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 8Author(s):
       
  • &rft.title=JACC+:+Basic+to+Translational+Science&rft.issn=2452-302X&rft.date=&rft.volume=">Paradoxical Cardiorenal Responses Following Acute Vasodilator/Natriuretic
           Treatment in Presystolic Heart Failure: Should We Be Surprised' ∗

    • Abstract: Publication date: December 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 8Author(s): Tamar S. Polonsky, George L. Bakris
       
  • Correction

    • Abstract: Publication date: December 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 8Author(s):
       
  • Stabilizing Peri-Stent Restenosis Using a Novel Therapeutic Carrier

    • Abstract: Publication date: Available online 28 November 2019Source: JACC: Basic to Translational ScienceAuthor(s): Patrick H. Kee, Melanie R. Moody, Shao-Ling Huang, Hyunggun Kim, Xing Yin, Tao Peng, Susan T. Laing, Melvin E. Klegerman, Mohammad H. Rahbar, Deborah Vela, Curtis Genstler, Kevin J. Haworth, Christy K. Holland, David D. McPhersonSummaryLate in-stent restenosis remains a significant problem. Bare-metal stents were implanted into peripheral arteries in miniature swine, followed by direct intra-arterial infusion of nitric oxide–loaded echogenic liposomes (ELIPs) and anti–intercellular adhesion molecule-1 conjugated ELIPs loaded with pioglitazone exposed to an endovascular catheter with an ultrasonic core. Ultrasound-facilitated delivery of ELIP formulations into stented peripheral arteries attenuated neointimal growth. Local atheroma-targeted, ultrasound-triggered delivery of nitric oxide and pioglitazone, an anti-inflammatory peroxisome proliferator–activated receptor-γ agonist, into stented arteries has the potential to stabilize stent-induced neointimal growth and obviate the need for long-term antiplatelet therapy.Visual Graphical abstract for this article
       
  • CFTR Therapeutics Normalize Cerebral Perfusion Deficits in Mouse Models
           of Heart Failure and Subarachnoid Hemorrhage

    • Abstract: Publication date: Available online 27 November 2019Source: JACC: Basic to Translational ScienceAuthor(s): Darcy Lidington, Jessica C. Fares, Franziska E. Uhl, Danny D. Dinh, Jeffrey T. Kroetsch, Meghan Sauvé, Firhan A. Malik, Frank Matthes, Lotte Vanherle, Arman Adel, Abdul Momen, Hangjun Zhang, Roozbeh Aschar-Sobbi, Warren D. Foltz, Hoyee Wan, Manabu Sumiyoshi, R. Loch Macdonald, Mansoor Husain, Peter H. Backx, Scott P. HeximerSummaryHeart failure (HF) and subarachnoid hemorrhage (SAH) chronically reduce cerebral perfusion, which negatively affects clinical outcome. This work demonstrates a strong relationship between cerebral artery cystic fibrosis transmembrane conductance regulator (CFTR) expression and altered cerebrovascular reactivity in HF and SAH. In HF and SAH, CFTR corrector compounds (C18 or lumacaftor) normalize pathological alterations in cerebral artery CFTR expression, vascular reactivity, and cerebral perfusion, without affecting systemic hemodynamic parameters. This normalization correlates with reduced neuronal injury. Therefore, CFTR therapeutics have emerged as valuable clinical tools to manage cerebrovascular dysfunction, impaired cerebral perfusion, and neuronal injury.Visual Graphical abstract for this article
       
  • Breastfeeding in Patients With Heart Failure: Lack of Evidence and
           Consensus

    • Abstract: Publication date: November 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 7Author(s): Tobias Koenig, Denise Hilfiker-Kleiner, Johann Bauersachs
       
  • Telomeres as Therapeutic Targets in Heart Disease

    • Abstract: Publication date: November 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 7Author(s): Jih-Kai Yeh, Mei-Hsiu Lin, Chao-Yung WangSummaryTelomeres are double-stranded repeats of G-rich tandem DNA sequences that gradually shorten with each cell division. Aging, inflammation, and oxidative stress accelerate the process of telomere shortening. Telomerase counteracts this process by maintaining and elongating the telomere length. Patients with atherosclerotic diseases and cardiovascular risk factors (e.g., smoking, obesity, sedentary lifestyle, and hypertension) have shorter leukocyte telomere length. Following myocardial infarction, telomerase expression and activity in cardiomyocytes and endothelial cells increase significantly, implying that telomerase plays a role in regulating tissue repairs in heart diseases. Although previous studies have focused on the changes of telomeres in heart diseases and the telomere length as a marker for aging cardiovascular systems, recent studies have explored the potential of telomeres and telomerase in the treatment of cardiovascular diseases. This review discusses the significant advancements of telomere therapeutics in gene therapy, atherosclerosis, anti-inflammation, and immune modulation in patients with cardiovascular diseases.Central IllustrationGraphical abstract for this article
       
  • Limitations of Animal Studies for Predicting Toxicity in Clinical Trials:
           Is it Time to Rethink Our Current Approach'

    • Abstract: Publication date: November 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 7Author(s): Gail A. Van NormanSummaryAnimal testing is used in pharmaceutical and industrial research to predict human toxicity, and yet analysis suggests that animal models are poor predictors of drug safety in humans. The cost of animal research is high—in dollars, delays in drug approval, and in the loss of potentially beneficial drugs for human use. Human subjects have been harmed in the clinical testing of drugs that were deemed safe by animal studies. Increasingly, investigators are questioning the scientific merit of animal research. This review discusses issues in using animals to predict human toxicity in pharmaceutical development. Part 1 focuses on scientific concerns over the validity of animal research. Part 2 will discuss alternatives to animal research and their validation and use in production of human pharmaceuticals.Graphical abstractGraphical abstract for this article
       
  • &rft.title=JACC+:+Basic+to+Translational+Science&rft.issn=2452-302X&rft.date=&rft.volume=">Empagliflozin and HFrEF: Known and Possible Benefits of NHE1
           Inhibition ∗

    • Abstract: Publication date: November 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 7Author(s): Seungho Jun, Miguel A. Aon, Nazareno PaolocciCorresponding AuthorGraphical abstract for this article
       
  • &rft.title=JACC+:+Basic+to+Translational+Science&rft.issn=2452-302X&rft.date=&rft.volume=">Out With the Old and in With the New: Not So Fast in Hypertrophic
           Cardiomyopathy ∗

    • Abstract: Publication date: November 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 7Author(s): Martin S. MaronCorresponding AuthorGraphical abstract for this article
       
  • &rft.title=JACC+:+Basic+to+Translational+Science&rft.issn=2452-302X&rft.date=&rft.volume=">Emerging Therapies for Dystrophic Cardiomyopathy ∗

    • Abstract: Publication date: November 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 7Author(s): Daniel J. Garry, Tamas AlexyCorresponding AuthorGraphical abstract for this article
       
  • &rft.title=JACC+:+Basic+to+Translational+Science&rft.issn=2452-302X&rft.date=&rft.volume=">Platelet Function Testing and Clinical Outcomes: Connecting the Dots ∗

    • Abstract: Publication date: November 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 7Author(s): David J. SchneiderCorresponding AuthorGraphical abstract for this article
       
  • Instructions For Authors

    • Abstract: Publication date: November 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 7Author(s):
       
  • Full Issue PDF

    • Abstract: Publication date: November 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 7Author(s):
       
  • Reply: Breastfeeding in Patients With Heart Failure: Lack of Evidence
           and Consensus

    • Abstract: Publication date: November 2019Source: JACC: Basic to Translational Science, Volume 4, Issue 7Author(s): Agnes Koczo, Amy Marino, Dennis M. McNamara
       
  • Seipin Knockout Mice Develop Heart Failure With Preserved
           Ejection Fraction

    • Abstract: Publication date: Available online 20 November 2019Source: JACC: Basic to Translational ScienceAuthor(s): Bo Bai, Wulin Yang, Yanyun Fu, Hannah Lee Foon, Wan Ting Tay, Kangmin Yang, Cuiting Luo, Jayantha Gunaratne, Philip Lee, Michael R. Zile, Aimin Xu, Calvin W.L. Chin, Carolyn S.P. Lam, Weiping Han, Yu WangSummaryThe lean diabetic patients with heart failure with preserved ejection fraction (HFpEF) in Asia suffer from adverse clinical outcomes and poor life quality. The suitable animal models are urgently needed for mechanistic study and therapeutic innovations. Our study reports that lipodystrophic mice with seipin depletion are lean, diabetic, and recapitulate major manifestations of clinical HFpEF, thereby clarifying that lean diabetes per se may produce HFpEF characteristics. We further demonstrate that increased cardiac titin phosphorylation and reactive interstitial fibrosis associated with neutrophil extracellular traps lead to left ventricular stiffness and suggest that both pathways may be potential therapeutic targets in Asian HFpEF patients.Visual Graphical abstract for this article
       
  • Preservation of Post-Infarction Cardiac Structure and Function via
           Long-Term Oral Formyl Peptide Receptor Agonist Treatment

    • Abstract: Publication date: Available online 13 November 2019Source: JACC: Basic to Translational ScienceAuthor(s): Ricardo A. García, Bruce R. Ito, John A. Lupisella, Nancy A. Carson, Mei-Yin Hsu, Gayani Fernando, Madeleine Heroux, Michel Bouvier, Elizabeth Dierks, Ellen K. Kick, David A. Gordon, Jian Chen, Gabe Mintier, Marilyn Carrier, Stéphane St-Onge, Himanshu Shah, Jordan Towne, Marcela Sotelo Bucardo, Xiuying Ma, Carol S. RyanSummaryDysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and progression towards heart failure. This study characterized the cellular and signaling properties of Compound 43 (Cmpd43), a dual FPR1/FPR2 agonist, and examined whether Cmpd43 treatment improves LV and infarct remodeling in rodent MI models. Cmpd43 stimulated FPR1/2-mediated signaling, enhanced proresolution cellular function, and modulated cytokines. Cmpd43 increased LV function and reduced chamber remodeling while increasing proresolution macrophage markers. The findings demonstrate that FPR agonism improves cardiac structure and function post-MI.Visual Graphical abstract for this article
       
  • Associations of Interleukin-5 With Plaque Development and Cardiovascular
           Events

    • Abstract: Publication date: Available online 6 November 2019Source: JACC: Basic to Translational ScienceAuthor(s): Anki Knutsson, Harry Björkbacka, Pontus Dunér, Gunnar Engström, Christoph J. Binder, Anna Hultgårdh Nilsson, Jan NilssonSummaryExperimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malmö Diet and Cancer study. However, presence of a plaque at the carotid bifurcation was associated with lower IL-5 and IL-5 deficiency resulted in increased plaque development at sites of oscillatory blood flow in Apoe−/− mice suggesting a protective role for IL-5 in plaque development.Visual Graphical abstract for this article
       
  • Can One Person Make a Difference': Remembering the Remarkable Life and
           Career of Alfred Bove

    • Abstract: Publication date: Available online 6 November 2019Source: JACC: Basic to Translational ScienceAuthor(s): Douglas L. Mann
       
  • Unraveling the Molecular Mechanism of Action of Empagliflozin in
           Heart Failure With Reduced Ejection Fraction With or Without Diabetes

    • Abstract: Publication date: Available online 23 October 2019Source: JACC: Basic to Translational ScienceAuthor(s): Oriol Iborra-Egea, Evelyn Santiago-Vacas, Salva R. Yurista, Josep Lupón, Milton Packer, Stephane Heymans, Faiez Zannad, Javed Butler, Domingo Pascual-Figal, Antonio Lax, Julio Núñez, Rudolf A. de Boer, Antoni Bayés-GenísSummaryThe mechanism of action of empagliflozin in heart failure with reduced ejection fraction (HFrEF) was deciphered using deep learning in silico analyses together with in vivo validation. The most robust mechanism of action involved the sodium-hydrogen exchanger-1 (NHE1) co-transporter with 94.7% accuracy, which was similar for diabetics and nondiabetics. Notably, direct NHE1 blockade by empagliflozin ameliorated cardiomyocyte cell death by restoring expression of X-linked inhibitor of apoptosis (XIAP) and baculoviral IAP repeat-containing protein 5 (BIRC5). These results were independent of diabetes mellitus comorbidity, suggesting that empagliflozin may emerge as a new treatment in HFrEF.Visual Graphical abstract for this article
       
  • Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Age-Related
           Cardiac Dysfunction: Hope for Better Aging'

    • Abstract: Publication date: Available online 16 October 2019Source: JACC: Basic to Translational ScienceAuthor(s): Paola C. Rosas, Chad M. Warren, Heidi A. Creed, Jerome P. Trzeciakowski, R. John Solaro, Carl W. TongSummaryCardiac myosin binding protein-C (cMyBP-C) phosphorylation prevents aging-related cardiac dysfunction. We tested this hypothesis by aging genetic mouse models of hypophosphorylated cMyBP-C, wild-type equivalent, and phosphorylated-mimetic cMyBP-C for 18 to 20 months. Phosphorylated-mimetic cMyBP-C mice exhibited better survival, better preservation of systolic and diastolic functions, and unchanging wall thickness. Wild-type equivalent mice showed decreasing cMyBP-C phosphorylation along with worsening cardiac function and hypertrophy approaching those found in hypophosphorylated cMyBP-C mice. Intact papillary muscle experiments suggested that cMyBP-C phosphorylation increased cross-bridge detachment rates as the underlying mechanism. Thus, phosphorylating cMyBP-C is a novel mechanism with potential to treat aging-related cardiac dysfunction.Visual Graphical abstract for this article
       
  • Electrophysiological and Contractile Effects of Disopyramide in Patients
           With Obstructive Hypertrophic Cardiomyopathy: a Translational Study

    • Abstract: Publication date: Available online 9 October 2019Source: JACC: Basic to Translational ScienceAuthor(s): Raffaele Coppini, Cecilia Ferrantini, Josè Manuel Pioner, Lorenzo Santini, Zhinuo J. Wang, Chiara Palandri, Marina Scardigli, Giulia Vitale, Leonardo Sacconi, Pierluigi Stefàno, Laura Flink, Katherine Riedy, Francesco Saverio Pavone, Elisabetta Cerbai, Corrado Poggesi, Alessandro Mugelli, Alfonso Bueno-Orovio, Iacopo Olivotto, Mark V. SherridSummaryDisopyramide is effective and safe in patients with obstructive hypertrophic cardiomyopathy. However, its cellular and molecular mechanisms of action are unknown. We tested disopyramide in cardiomyocytes from the septum of surgical myectomy patients: disopyramide inhibits multiple ion channels, leading to lower Ca transients and force, and shortens action potentials, thus reducing cellular arrhythmias. The electrophysiological profile of disopyramide explains the efficient reduction of outflow gradients but also the limited prolongation of the QT interval and the absence of arrhythmic side effects observed in 39 disopyramide-treated patients. In conclusion, our results support the idea that disopyramide is safe for outpatient use in obstructive patients.Visual Graphical abstract for this article
       
  • Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular
           Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate

    • Abstract: Publication date: Available online 2 October 2019Source: JACC: Basic to Translational ScienceAuthor(s): Stephen C. Kolwicz, John K. Hall, Farid Moussavi-Harami, Xiolan Chen, Stephen D. Hauschka, Jeffrey S. Chamberlain, Michael Regnier, Guy L. OdomSummaryMutations in the gene encoding for dystrophin leads to structural and functional deterioration of cardiomyocytes and is a hallmark of cardiomyopathy in Duchenne muscular dystrophy (DMD) patients. Administration of recombinant adeno-associated viral vectors delivering microdystrophin or ribonucleotide reductase (RNR), under muscle-specific regulatory control, rescues both baseline and high workload-challenged hearts in an aged, DMD mouse model. However, only RNR treatments improved both systolic and diastolic function under those conditions. Cardiac-specific recombinant adeno-associated viral treatment of RNR holds therapeutic promise for improvement of cardiomyopathy in DMD patients.Visual Graphical abstract for this article
       
  • Pharmacodynamic Effects of Vorapaxar in Patients With and Without
           Diabetes Mellitus Treated With Dual Antiplatelet Therapy: Results of the
           OPTIMUS -5 (Optimizing Anti-Platelet Therapy in Diabetes Mellitus -5)
           Study

    • Abstract: Publication date: Available online 1 September 2019Source: JACC: Basic to Translational ScienceAuthor(s): Francesco Franchi, Fabiana Rollini, Victor Kairouz, Jose Rivas Rios, Andrea Rivas, Malhar Agarwal, Maryuri Briceno, Mustafa Wali, Ahmed Nawaz, Gabriel Silva, Zubair Shaikh, Naji Maaliki, Latonya Been, Jason Piraino, Andres M. Pineda, Siva Suryadevara, Daniel Soffer, Martin M. Zenni, Lisa K. Jennings, Theodore A. BassSummaryVorapaxar reduces thrombotic cardiovascular events at the expense of increased bleeding. However, the differential pharmacodynamic (PD) effects of vorapaxar according to diabetes mellitus (DM) status are unknown. Moreover, although withdrawal of aspirin has emerged as a bleeding reduction strategy, the PD effects of stopping aspirin in patients treated with vorapaxar also are unknown. In this prospective PD investigation, vorapaxar was associated with reduced platelet-mediated thrombogenicity without affecting clot kinetics irrespective of DM status. However, platelet-mediated thrombogenicity increased after aspirin withdrawal, particularly among patients with DM. (Optimizing anti-Platelet Therapy In diabetes MellitUS-5 Study [OPTIMUS-5]; NCT02548650)Visual Graphical abstract for this article
       
 
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