Subjects -> MEDICAL SCIENCES (Total: 8447 journals)
    - ALLERGOLOGY AND IMMUNOLOGY (212 journals)
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CARDIOVASCULAR DISEASES (330 journals)                  1 2 | Last

Showing 1 - 200 of 330 Journals sorted alphabetically
Acta Angiologica     Open Access   (Followers: 5)
Acta Cardiologica     Hybrid Journal   (Followers: 2)
Acute Cardiac Care     Hybrid Journal   (Followers: 7)
Adipositas - Ursachen, Folgeerkrankungen, Therapie     Hybrid Journal  
AJP Heart and Circulatory Physiology     Hybrid Journal   (Followers: 12)
Aktuelle Kardiologie     Hybrid Journal   (Followers: 1)
American Heart Journal     Hybrid Journal   (Followers: 59)
American Journal of Cardiology     Hybrid Journal   (Followers: 67)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 17)
American Journal of Hypertension     Hybrid Journal   (Followers: 28)
Anales de Cirugia Vascular     Full-text available via subscription   (Followers: 1)
Anatolian Journal of Cardiology     Open Access   (Followers: 6)
Angiología     Full-text available via subscription  
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1)
Angiology     Hybrid Journal   (Followers: 3)
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (Followers: 1)
Annals of Noninvasive Electrocardiology     Hybrid Journal   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 12)
AORTA     Open Access  
Archives of Cardiovascular Diseases     Full-text available via subscription   (Followers: 5)
Archives of Cardiovascular Diseases Supplements     Full-text available via subscription   (Followers: 3)
Archives of Cardiovascular Imaging     Open Access   (Followers: 2)
Archivos de cardiología de México     Open Access   (Followers: 1)
Argentine Journal of Cardiology (English edition)     Open Access   (Followers: 2)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 2)
Arteriosclerosis, Thrombosis and Vascular Biology     Full-text available via subscription   (Followers: 32)
Artery Research     Hybrid Journal   (Followers: 4)
ARYA Atherosclerosis     Open Access  
ASAIO Journal     Hybrid Journal   (Followers: 3)
ASEAN Heart Journal     Open Access   (Followers: 2)
Asian Cardiovascular and Thoracic Annals     Hybrid Journal   (Followers: 2)
Aswan Heart Centre Science & Practice Services     Open Access   (Followers: 1)
Atherosclerosis : X     Open Access  
Bangladesh Heart Journal     Open Access   (Followers: 3)
Basic Research in Cardiology     Hybrid Journal   (Followers: 10)
BMC Cardiovascular Disorders     Open Access   (Followers: 22)
Brain Circulation     Open Access   (Followers: 1)
British Journal of Cardiology     Full-text available via subscription   (Followers: 17)
Canadian Journal of Cardiology     Hybrid Journal   (Followers: 18)
Cardiac Cath Lab Director     Full-text available via subscription  
Cardiac Electrophysiology Review     Hybrid Journal   (Followers: 2)
Cardiocore     Full-text available via subscription   (Followers: 1)
Cardiogenetics     Open Access   (Followers: 3)
Cardiology     Full-text available via subscription   (Followers: 20)
Cardiology and Angiology: An International Journal     Open Access   (Followers: 1)
Cardiology and Therapy     Open Access   (Followers: 12)
Cardiology Clinics     Full-text available via subscription   (Followers: 14)
Cardiology in Review     Hybrid Journal   (Followers: 8)
Cardiology in the Young     Hybrid Journal   (Followers: 34)
Cardiology Journal     Open Access   (Followers: 6)
Cardiology Plus     Open Access   (Followers: 1)
Cardiology Research     Open Access   (Followers: 15)
Cardiology Research and Practice     Open Access   (Followers: 10)
Cardiopulmonary Physical Therapy Journal     Hybrid Journal   (Followers: 7)
Cardiorenal Medicine     Full-text available via subscription   (Followers: 1)
Cardiothoracic Surgeon     Open Access   (Followers: 1)
CardioVasc     Full-text available via subscription   (Followers: 1)
Cardiovascular & Haematological Disorders - Drug Targets     Hybrid Journal   (Followers: 1)
Cardiovascular & Hematological Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 2)
CardioVascular and Interventional Radiology     Hybrid Journal   (Followers: 15)
Cardiovascular and Thoracic Open     Open Access  
Cardiovascular Diabetology     Open Access   (Followers: 10)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 14)
Cardiovascular Endocrinology & Metabolism     Hybrid Journal   (Followers: 1)
Cardiovascular Engineering     Hybrid Journal   (Followers: 1)
Cardiovascular Engineering and Technology     Hybrid Journal   (Followers: 1)
Cardiovascular Intervention and Therapeutics     Hybrid Journal   (Followers: 5)
Cardiovascular Journal     Open Access   (Followers: 6)
Cardiovascular Journal of Africa     Full-text available via subscription   (Followers: 5)
Cardiovascular Journal of South Africa     Full-text available via subscription   (Followers: 1)
Cardiovascular Medicine in General Practice     Full-text available via subscription   (Followers: 7)
Cardiovascular Pathology     Hybrid Journal   (Followers: 4)
Cardiovascular Regenerative Medicine     Open Access  
Cardiovascular Research     Hybrid Journal   (Followers: 15)
Cardiovascular Revascularization Medicine     Hybrid Journal   (Followers: 1)
Cardiovascular System     Open Access  
Cardiovascular Therapeutics     Open Access   (Followers: 1)
Cardiovascular Toxicology     Hybrid Journal   (Followers: 6)
Cardiovascular Ultrasound     Open Access   (Followers: 5)
Case Reports in Cardiology     Open Access   (Followers: 7)
Catheterization and Cardiovascular Interventions     Hybrid Journal   (Followers: 3)
Cerebrovascular Diseases     Full-text available via subscription   (Followers: 3)
Cerebrovascular Diseases Extra     Open Access  
Chest     Full-text available via subscription   (Followers: 101)
Choroby Serca i Naczyń     Open Access   (Followers: 1)
Circulation     Hybrid Journal   (Followers: 251)
Circulation : Cardiovascular Imaging     Hybrid Journal   (Followers: 15)
Circulation : Cardiovascular Interventions     Hybrid Journal   (Followers: 17)
Circulation : Cardiovascular Quality and Outcomes     Hybrid Journal   (Followers: 11)
Circulation : Genomic and Precision Medicine     Hybrid Journal   (Followers: 15)
Circulation : Heart Failure     Hybrid Journal   (Followers: 26)
Circulation Research     Hybrid Journal   (Followers: 36)
Cirugía Cardiovascular     Open Access  
Clínica e Investigación en Arteriosclerosis     Full-text available via subscription  
Clínica e Investigación en arteriosclerosis (English Edition)     Hybrid Journal  
Clinical and Experimental Hypertension     Hybrid Journal   (Followers: 3)
Clinical Cardiology     Hybrid Journal   (Followers: 11)
Clinical Hypertension     Open Access   (Followers: 5)
Clinical Medicine Insights : Cardiology     Open Access   (Followers: 6)
Clinical Research in Cardiology     Hybrid Journal   (Followers: 6)
Clinical Research in Cardiology Supplements     Hybrid Journal  
Clinical Trials and Regulatory Science in Cardiology     Open Access   (Followers: 4)
Congenital Heart Disease     Hybrid Journal   (Followers: 6)
Congestive Heart Failure     Hybrid Journal   (Followers: 4)
Cor et Vasa     Full-text available via subscription   (Followers: 1)
Coronary Artery Disease     Hybrid Journal   (Followers: 2)
CorSalud     Open Access  
Critical Pathways in Cardiology     Hybrid Journal   (Followers: 4)
Current Cardiology Reports     Hybrid Journal   (Followers: 7)
Current Cardiology Reviews     Hybrid Journal   (Followers: 4)
Current Cardiovascular Imaging Reports     Hybrid Journal   (Followers: 1)
Current Cardiovascular Risk Reports     Hybrid Journal  
Current Heart Failure Reports     Hybrid Journal   (Followers: 5)
Current Hypertension Reports     Hybrid Journal   (Followers: 6)
Current Hypertension Reviews     Hybrid Journal   (Followers: 6)
Current Opinion in Cardiology     Hybrid Journal   (Followers: 14)
Current Problems in Cardiology     Hybrid Journal   (Followers: 3)
Current Research : Cardiology     Full-text available via subscription   (Followers: 1)
Current Treatment Options in Cardiovascular Medicine     Hybrid Journal   (Followers: 1)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 5)
CVIR Endovascular     Open Access   (Followers: 1)
Der Kardiologe     Hybrid Journal   (Followers: 2)
Echo Research and Practice     Open Access   (Followers: 2)
Echocardiography     Hybrid Journal   (Followers: 4)
Egyptian Heart Journal     Open Access   (Followers: 2)
Egyptian Journal of Cardiothoracic Anesthesia     Open Access  
ESC Heart Failure     Open Access   (Followers: 4)
European Heart Journal     Hybrid Journal   (Followers: 66)
European Heart Journal - Cardiovascular Imaging     Hybrid Journal   (Followers: 10)
European Heart Journal - Cardiovascular Pharmacotherapy     Full-text available via subscription   (Followers: 2)
European Heart Journal - Quality of Care and Clinical Outcomes     Hybrid Journal  
European Heart Journal : Acute Cardiovascular Care     Hybrid Journal   (Followers: 1)
European Heart Journal : Case Reports     Open Access   (Followers: 1)
European Heart Journal Supplements     Hybrid Journal   (Followers: 8)
European Journal of Cardio-Thoracic Surgery     Hybrid Journal   (Followers: 9)
European Journal of Cardio-Thoracic Surgery Supplements     Full-text available via subscription   (Followers: 2)
European Journal of Cardiovascular Nursing     Hybrid Journal   (Followers: 5)
European Journal of Heart Failure     Hybrid Journal   (Followers: 14)
European Journal of Preventive Cardiology.     Hybrid Journal   (Followers: 6)
European Stroke Organisation     Hybrid Journal   (Followers: 3)
Experimental & Translational Stroke Medicine     Open Access   (Followers: 9)
Expert Review of Cardiovascular Therapy     Full-text available via subscription   (Followers: 3)
Folia Cardiologica     Open Access  
Forum Zaburzeń Metabolicznych     Hybrid Journal  
Frontiers in Cardiovascular Medicine     Open Access   (Followers: 1)
Future Cardiology     Hybrid Journal   (Followers: 6)
General Thoracic and Cardiovascular Surgery     Hybrid Journal   (Followers: 3)
Global Cardiology Science and Practice     Open Access   (Followers: 5)
Global Heart     Hybrid Journal   (Followers: 3)
Heart     Hybrid Journal   (Followers: 48)
Heart and Mind     Open Access  
Heart and Vessels     Hybrid Journal  
Heart Failure Clinics     Full-text available via subscription   (Followers: 2)
Heart Failure Reviews     Hybrid Journal   (Followers: 3)
Heart India     Open Access   (Followers: 2)
Heart International     Full-text available via subscription  
Heart Rhythm     Hybrid Journal   (Followers: 11)
Heart Views     Open Access   (Followers: 2)
HeartRhythm Case Reports     Open Access  
Hellenic Journal of Cardiology     Open Access   (Followers: 1)
Herz     Hybrid Journal   (Followers: 3)
High Blood Pressure & Cardiovascular Prevention     Full-text available via subscription   (Followers: 2)
Hypertension     Full-text available via subscription   (Followers: 23)
Hypertension in Pregnancy     Hybrid Journal   (Followers: 9)
Hypertension Research     Hybrid Journal   (Followers: 5)
Ibrahim Cardiac Medical Journal     Open Access  
IJC Heart & Vessels     Open Access   (Followers: 1)
IJC Heart & Vasculature     Open Access   (Followers: 1)
IJC Metabolic & Endocrine     Open Access   (Followers: 1)
Indian Heart Journal     Open Access   (Followers: 5)
Indian Journal of Cardiovascular Disease in Women WINCARS     Open Access  
Indian Journal of Thoracic and Cardiovascular Surgery     Hybrid Journal  
Indian Pacing and Electrophysiology Journal     Open Access   (Followers: 1)
Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery     Hybrid Journal   (Followers: 1)
Insuficiencia Cardíaca     Open Access  
Interactive CardioVascular and Thoracic Surgery     Hybrid Journal   (Followers: 7)
International Cardiovascular Forum Journal     Open Access  
International Journal of Angiology     Hybrid Journal   (Followers: 2)
International Journal of Cardiology     Hybrid Journal   (Followers: 18)
International Journal of Cardiology Hypertension     Open Access   (Followers: 1)
International Journal of Cardiovascular and Cerebrovascular Disease     Open Access   (Followers: 2)
International Journal of Cardiovascular Imaging     Hybrid Journal   (Followers: 2)
International Journal of Cardiovascular Research     Hybrid Journal   (Followers: 6)
International Journal of Heart Rhythm     Open Access  
International Journal of Hypertension     Open Access   (Followers: 8)
International Journal of Hyperthermia     Open Access  
International Journal of Stroke     Hybrid Journal   (Followers: 30)
International Journal of the Cardiovascular Academy     Open Access  
Interventional Cardiology Clinics     Full-text available via subscription   (Followers: 2)
Interventional Cardiology Review     Full-text available via subscription  
JACC : Basic to Translational Science     Open Access   (Followers: 5)
JACC : Cardiovascular Imaging     Hybrid Journal   (Followers: 18)
JACC : Cardiovascular Interventions     Hybrid Journal   (Followers: 17)
JACC : Heart Failure     Full-text available via subscription   (Followers: 14)
JAMA Cardiology     Hybrid Journal   (Followers: 28)
JMIR Cardio     Open Access  
Jornal Vascular Brasileiro     Open Access  
Journal of Clinical & Experimental Cardiology     Open Access   (Followers: 5)
Journal of Arrhythmia     Open Access  
Journal of Cardiac Critical Care TSS     Open Access   (Followers: 1)

        1 2 | Last

Similar Journals
Journal Cover
Current Problems in Cardiology
Journal Prestige (SJR): 1.666
Citation Impact (citeScore): 2
Number of Followers: 3  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0146-2806 - ISSN (Online) 1535-6280
Published by Elsevier Homepage  [3206 journals]
  • Acute myocardial infarction due to antiphospholipid syndrome - case report
           and review of the literature
    • Abstract: Publication date: Available online 20 February 2020Source: Current Problems in CardiologyAuthor(s): Karolina Semczuk-Kaczmarek, Anna E. Platek, Anna Ryś-Czaporowska, Filip M. Szymanski, Krzysztof J. FilipiakAbstractWe present a case of acute myocardial infarction (AMI) secondary to arterial thromboembolism in a 25-year-old man with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). To our knowledge, based on the literature review, this patient is the youngest one with the acute coronary syndrome as a complication of APS. Acute myocardial infarction secondary to arterial thromboembolism is a rare presentation of antiphospholipid syndrome. There are different recommended anticoagulation strategies in APS patients according to the presence of thrombosis of arterial or venous origin. Potential difficulties in the treatment may occur based on the clinical scenarios. A large number of APS patients require lifelong oral anticoagulation with vitamin K antagonists. Some DOACs are being studied as drugs potentially useful in APS treatment. The recent studies suggest the role of aGAPSS score in assessing the risk of a recurrent thrombotic event as well as acute myocardial infarction in APS patients.
       
  • The new ESC guidelines for the diagnosis and management of chronic
           coronary syndromes: the good and the not so good
    • Abstract: Publication date: Available online 14 February 2020Source: Current Problems in CardiologyAuthor(s): R. Ferrari, R. Pavasini, S. Censi, A. Squeri, G. Rosano AimDuring the annual meeting in Paris, the European Society of Cardiology released the new guidelines for the diagnosis and management of chronic coronary syndromes that will replace the 2013 guidelines on stable coronary artery disease. We intend to provide a brief commentary on what, in our opinion, is good and what is not as good.Methods and resultsour careful analysis shows that the 2019 guidelines contain a number of positive innovations, including a new definition, a central role of non-invasive testing for myocardial ischaemia, the most contemporary prevalence of the disease, the fact that medical therapy remains paramount despite the important advances in revascularisation and many other good issues as well as some limitations. The section on medical therapy of CCS patients shows some inconsistency between text and the suggested scheme as well as contradictions with recommendations of regulatory agencies.ConclusionIt is not immediate to appreciate what is good and what is not so good in guidelines, which are often read in a hurry. We have provided a short commentary for the readers who usually concentrate more on the figures and flowcharts rather than on the text.
       
  • Evolution of Acute Pulmonary Embolism Management Review Article
    • Abstract: Publication date: Available online 14 February 2020Source: Current Problems in CardiologyAuthor(s): Mohammed Faluk, S. Mustajab Hasan, Jay J. Chacko, Ramy Abdelmaseih, Jigar Patel Acute pulmonary emboli are a major cause of morbidity and mortality and require prompt evaluation, diagnosis and treatment. To date, anticoagulation using Low molecular weight heparin or Non-Vitamin K oral anticoagulants has been the mainstay of treatment in the subset of patients in whom PE does not compromise hemodynamics. On the other hand however, patients with massive PE and shock, thrombolytic therapy is necessary. This raises the question whether ultrasound assisted catheter directed thrombolytic delivery might be superior to systemic administration. This review article aims to consolidate recent literature to help achieve a better understanding towards the utility of catheter directed therapy.
       
  • Aspirin For Primary Prevention Of Coronary Artery Disease
    • Abstract: Publication date: Available online 14 February 2020Source: Current Problems in CardiologyAuthor(s): Aditi Ujjawal, Manasvi Gupta, Raktim K. Ghosh, Vardhmaan Jain, Dhrubajyoti Bandyopadhyay, Arman Qamar, Wilbert S. Aronow, Prakash Deedwania, Samir Kapadia, Carl J. Lavie Primary prevention of coronary artery disease (CAD) is an important means to reduce the burden of the disease. Aspirin has been widely prescribed over the last several decades as part of primary CAD prevention strategy. However, three recent hallmark trials - ARRIVE, ASCEND and ASPREE have raised serious question about this common practice. Although, aspirin reduced incidence of non-fatal MI and stroke in the recent studies, bleeding risk was higher. In the present era, where regular exercise, healthy diet, smoking cessation, and statins are used to manage the risk factors of CAD, additional prescription of aspirin seems more harmful than beneficial. The guidelines of major societies such as European Society of Cardiology (ESC), American College of Cardiology (ACC), and American Heart Association (AHA) also reflect this shift. In this article, the authors aim to highlight the current evidence on aspirin use for primary prevention of CAD, in the context of evolving contrasting clinical trial data from the last two decades. We also highlight the pertinent sections of the most recent clinical guidelines of ESC, ACC, and AHA in this article.
       
  • Modern Management of ST-Segment Elevation Myocardial Infarction
    • Abstract: Publication date: March 2020Source: Current Problems in Cardiology, Volume 45, Issue 3Author(s): Jennifer Frampton, James T. Devries, Terrence D. Welch, Bernard J. Gersh Disruption of intracoronary plaque with thrombus formation resulting in severe or total occlusion of the culprit coronary artery provides the pathophysiologic foundation for ST-segment elevation myocardial infarction (STEMI). Management of STEMI focuses on timely restoration of coronary blood flow along with antithrombotic therapies and secondary prevention strategies. The purpose of this review is to discuss the epidemiology, pathophysiology, and diagnosis of STEMI. In addition, the review will focus on guideline-directed therapy for these patients and review potential associated complications.
       
  • Author Bio
    • Abstract: Publication date: March 2020Source: Current Problems in Cardiology, Volume 45, Issue 3Author(s):
       
  • Guidelines for Authors
    • Abstract: Publication date: March 2020Source: Current Problems in Cardiology, Volume 45, Issue 3Author(s):
       
  • Editor’s Message
    • Abstract: Publication date: March 2020Source: Current Problems in Cardiology, Volume 45, Issue 3Author(s):
       
  • Information for Readers
    • Abstract: Publication date: March 2020Source: Current Problems in Cardiology, Volume 45, Issue 3Author(s):
       
  • Title Page
    • Abstract: Publication date: March 2020Source: Current Problems in Cardiology, Volume 45, Issue 3Author(s):
       
  • Foreword
    • Abstract: Publication date: March 2020Source: Current Problems in Cardiology, Volume 45, Issue 3Author(s):
       
  • Patent Foramen Ovale: A Comprehensive Review
    • Abstract: Publication date: February 2020Source: Current Problems in Cardiology, Volume 45, Issue 2Author(s): Meron K. Teshome, Khalid Najib, Chioma C. Nwagbara, Oluwaseun A. Akinseye, Uzoma N. Ibebuogu
       
  • Author Bio
    • Abstract: Publication date: February 2020Source: Current Problems in Cardiology, Volume 45, Issue 2Author(s):
       
  • Guidelines for Authors
    • Abstract: Publication date: February 2020Source: Current Problems in Cardiology, Volume 45, Issue 2Author(s):
       
  • Editor’s Message
    • Abstract: Publication date: February 2020Source: Current Problems in Cardiology, Volume 45, Issue 2Author(s):
       
  • Title Page
    • Abstract: Publication date: February 2020Source: Current Problems in Cardiology, Volume 45, Issue 2Author(s):
       
  • Foreword
    • Abstract: Publication date: February 2020Source: Current Problems in Cardiology, Volume 45, Issue 2Author(s):
       
  • Differences in symptomatology and clinical course of acute coronary
           syndromes in women ≤ 45 years of age compared to older women
    • Abstract: Publication date: Available online 1 December 2019Source: Current Problems in CardiologyAuthor(s): Maciej Bęćkowski, Ilona Kowalik, Krzysztof Jaworski, Rafał Dąbrowski, Marek Gierlotka, Mariusz Gąsior, Lech Poloński, Tomasz Zdrojewski, Jarosław Karwowski, Wojciech Drygas, Hanna SzwedABSTRACTBackgroundAcute coronary syndromes (ACS) in young people are rare. The data regarding differences in symptoms in relation to age are scarce, which may have an influence on outcomes.ObjectivesThe aim of this study was to evaluate the differences in the clinical course of ACS between younger women (≤ 45 years old) and older women (63 to 64 years old).Design and PatientsWe compared 7481 women with ACS from the Polish Registry of Acute Coronary Syndromes (PL-ACS) between 2007 and 2014 (1834 women aged ≤ 45 years and 5647 women aged 63 to 64 years).ResultsThe predominant symptom of ACS in both groups was chest pain, with a higher incidence occurring in younger women (90.4% vs. 88.5%, p = 0.025). Pre-hospital cardiac arrest occurred more often in younger women (2.1% vs. 0.8%, p < 0.001), and onset-to-balloon time was shorter (8.9 vs. 15.2 hours, p
       
  • Chagas Disease: Chronic Chagas Cardiomyopathy
    • Abstract: Publication date: Available online 1 December 2019Source: Current Problems in CardiologyAuthor(s): Natalia Giraldo Echavarría, Luis E. Echeverría, Merrill Stewart, Catalina Gallego, Clara Saldarriaga
       
  • Sarcoidosis-Associated Pulmonary Hypertension: An Updated Review and
           Discussion of the Clinical Conundrum
    • Abstract: Publication date: Available online 30 November 2019Source: Current Problems in CardiologyAuthor(s): Adrian daSilva-deAbreu, Stacy A. MandrasABSTRACTPulmonary hypertension (PH) is a life-threatening disease with complex pathophysiology. The World Health Organization has classified PH in five groups according to etiology, the fifth of which corresponds to PH due to unknown or multiple mechanisms; including sarcoidosis-associated PH (SAPH). Although this system has been used to guide treatment recommendations according to each group, it does not provide much insight into the heterogeneous group 5. Furthermore, pulmonary vasodilators (PVD) have been contraindicated for patients in this cluster which represents a challenge for the management of SAPH which can sometimes improve with these PH-directed drugs. In this review, we discuss the classification of SAPH; as well as the evidence behind the use PVD, invasive procedures, and lung transplantation for treating SAPH; and the little that is known about his disease in the setting of cardiac sarcoidosis.
       
  • Chest X-Ray to Predict Difficult Right Transradial Cardiac Catheterization
           Due to Vascular Tortuosity: A Retrospective Study
    • Abstract: Publication date: Available online 20 September 2019Source: Current Problems in CardiologyAuthor(s): Salem A. Salem, Pooja S. Jagadish, Devarshi Ardeshna, Rami N. Khouzam, Shadwan Alsafwah, Abhinav Sharma, Dipan Uppal, Rafal Kedzierski, Nadish Garg Tortuous brachiocephalic artery may lead to procedural difficulties among patients undergoing right transradial cardiac catheterization. By prospectively identifying patients with this anatomic barrier, operators may choose an alternate catheterization site to avoid complications from switching midway. To assess brachiocephalic artery tortuosity, twenty-three patients who underwent challenging diagnostic coronary angiography by right transradial access were compared to a control group of twenty-nine patients who lacked brachiocephalic artery tortuosity. Preprocedural, plain chest x-rays were analyzed for measurable anatomic parameters and assessed for statistical significance between groups. The vertebrocarinal distance—the distance in centimeters between the spinous process of the first thoracic vertebra (T1) and the most caudal point of tracheal bifurcation, measured at and parallel to the midline—was the most reliable and statistically significant radiographic predictor of brachiocephalic artery tortuosity. Using this novel concept reduces procedure duration and radiation exposure by decreasing transradial cardiac catheterization failure rates.
       
  • Exergaming and Virtual Reality for Health: Implications for Cardiac
           Rehabilitation
    • Abstract: Publication date: Available online 12 September 2019Source: Current Problems in CardiologyAuthor(s): Samantha Bond, Deepika R. Laddu, Cemal Ozemek, Carl J Lavie, Ross Arena Cardiac Rehabilitation (CR) programs, focused on improving the health trajectory of patients with cardiovascular disease, strive to increase physical activity (PA) and cardiorespiratory fitness. However, historically low compliance with recommended PA has prompted exploration of alternatives to traditional courses of exercise therapy. One alternative, exergaming, or the requirement of physical exercise inherent to a video game's activities, has shown to have a promising impact in improving patient self-efficacy for exercise training using digital hardware (e.g., the Wii or the Xbox Kinect). Furthermore, novel technologies in virtual reality can provide an engaging, immersive environment for exergaming techniques, maximizing goal-oriented training and building self-efficacy for patients during CR. Many groundbreaking institutions are already calculating energy expenditure of commercially successful virtual reality games and finding promise in the cardiometabolic responses to a number of virtual reality games. Research is still limited in establishing the efficacy of these games, but virtual reality and exergaming are quickly proving to be appropriate and equivalent alternatives to traditional exercise programs. Though studies have examined the impact of prescriptive exergaming on PA, they have yet to examine the potential for genuine integration of game-based motivational techniques and immersive environments into clinical interaction. The purpose of this review is to describe the current body of evidence and the impact and future potential of virtual reality and exergaming. Further, we will introduce the concept of a ‘Clinical Arcade’ as a new approach to integration of these techniques in CR care.
       
  • Trends of Cardiac Complications in Patients with Rheumatoid Arthritis:
           Analysis of the United States National Inpatient Sample; 2005-2014
    • Abstract: Publication date: Available online 23 August 2019Source: Current Problems in CardiologyAuthor(s): Dhrubajyoti Bandyopadhyay, Upasana Banerjee, Adrija Hajra, Sandipan Chakraborty, Birendra Amgai, Raktim K Ghosh, Faris I Haddadin, Vivek Amit Modi, Kaushik Sinha, Wilbert S Aronow, Prakash Deedwania, Carl J Lavie BackgroundRheumatoid arthritis (RA) is a chronic inflammatory condition. Chronic inflammation is associated with atherosclerosis, hypertension (HTN), diabetes (DM), chronic obstructive pulmonary disease (COPD), chronic kidney disease (CKD). But sparse data are available regarding the trends of cardiovascular diseases (CVD) and complications in RA. We conducted a National Inpatient Sample (NIS) database analysis to demonstrate the trends of cardiac complications in patients with RA.MethodsWe used NIS data from 2005-2014 to identify admissions with the diagnosis of RA and identified who had associated cardiovascular complications also. The International Classification of Diseases-9th Revision-Clinical Modification (ICD-9-CM) codes were used for the diagnoses of RA; congestive heart failure (CHF), acute myocardial infarction (AMI), and atrial fibrillation (AF).ResultsA statistically significant increasing trend of CHF, AMI, and AF was found. Independent predictors of mortality in RA patients with CHF were age [odds ratio (OR) 1.02, confidence interval (CI) 1.017 to 1.024; P < 0.001)], COPD (OR 1.09, CI 1.01 to 1.18; P =0.023), cerebrovascular disease (OR 1.67, CI 1.44 to 1.95; P < 0.001), renal disease (OR 1.16, CI 1.07 to 1.27; P=0.001). Independent predictors of mortality in RA patients with AMI were age (OR 1.03, CI 1.02 to1.04; P < 0.001), COPD (OR 1.67, CI 1.40 to 2.00; P< 0.001), cerebrovascular disease (OR 2.207, CI 1.71 to 2.86; P< 0.001), renal disease (OR 1.42, CI 1.16 to 1.75; P=0.001), and alcohol abuse (OR 2.73, CI 1.73 to 4.32; P< 0.001). Independent predictors of mortality in RA patients with AF were age (OR 1.02, CI 1.02 to 1.03; P < 0.001), race (OR 1.16, CI 1.02 to 1.31; P = 0.022), COPD (OR 1.56, CI 1.42 to1.71; P < 0.001), peripheral arterial disease (OR 1.34, CI 1.16 to 1.53; P < 0.001), cerebrovascular disease (OR 2.27, CI 1.0 to 2.58; P < 0.001), renal disease (OR 1.60, CI 1.44 to 1.80; P < 0.001). The mortality trend has increased significantly in the CHF (P = 0.025) and AF (P = 0.042) groups during this study period.ConclusionsWe have found a significant increase in trend of cardiovascular complications in RA patients. The proportion of patients, with cardiovascular co-morbidities, have also been increased significantly.
       
  • Update on Brugada Syndrome 2019
    • Abstract: Publication date: Available online 23 August 2019Source: Current Problems in CardiologyAuthor(s): Coppola Giuseppe, Corrado Egle, Curnis Antonio, Maglia Giampiero, Oriente Domenico, Mignano Antonino, Pedro Brugada Brugada syndrome (BrS) was first described in 1992 as an aberrant pattern of ST segment elevation in right precordial leads with an high incidence of sudden cardiac death (SCD) in patients with structurally normal heart. It represents 4 ∼ 12% of all SCD and 20% of SCD in patients with structurally normal heart. The extremely wide genetic heterogeneity of BrS and other inherited cardiac disorders makes this new area of genetic arrhytmology a fascinating one.This review shows the state of art in diagnosis, management and treatment of Brugada Syndrome focusing all the aspects regarding genetics and pre-implant genetic diagnosis of embryos, overlapping syndromes, risk stratification, familial screening, and future perspectives.Moreover the review analyzes key points like ECG criteria, the role of electrophysiological study (the role of ventricular programmed stimulation and the need of universal accepted protocol) and the importance of a correct risk stratification to clarify when implantable cardioverter defibrillator or a close follow up is needed.In recent years, cardiovascular studies have been focused on personalized risk assessment and to determine the most optimal therapy for an individual. The BrS syndrome has also benefited of these advances although there remain several key points to be elucidated.We will review the present knowledge, progress made and future research directions on BrS.
       
  • Decreasing Rates of Acute Kidney Injury After Percutaneous Coronary
           Interventions Through Education and Standardized Order Sets in a Large
           Tertiary Teaching Center
    • Abstract: Publication date: Available online 22 August 2019Source: Current Problems in CardiologyAuthor(s): Adrian daSilva-deAbreu, Sidhanta Gurung, William Bracamonte-Baran, Patrick Byrnes, Prakash Balan, Kevin Finkel, Richard Smalling, H. Vernon Anderson, Salman A. Arain Acute kidney injury (AKI) is a common complication of percutaneous coronary interventions (PCI), and it is associated with increased morbidity, mortality, and healthcare costs. Post-PCI AKI is a major quality outcome measured by the National Cardiovascular Data Registry for hospitals that perform PCI. We report the experience of a large, tertiary center with high standardized, post-PCI AKI rates in which we implemented multilevel interventions that included: 1) a multidisciplinary education module for all personnel involved in care of patients undergoing cardiac angiography, 2) a standardized electronic medical record based pre-procedure hydration protocol order set for patients undergoing cardiac angiography, and 3) a hydration task list to be completed by the care team the evening before the procedure or prior to admission. All this resulted in a constant decrease of the post-PCI AKI rates in remarkable magnitude, significantly stronger than the national tendency, demonstrating a center-specific behavior.
       
  • PERIOPERATIVE TROPONIN SCREENING IDENTIFIES PATIENTS AT HIGHER RISK FOR
           MAJOR CARDIOVASCULAR EVENTS IN NONCARDIAC SURGERY
    • Abstract: Publication date: Available online 29 June 2019Source: Current Problems in CardiologyAuthor(s): Maria Cláudia D.B.G. Costa, Mariana V Furtado, Flavia Kessler Borges, Patricia Klarmann Ziegelmann, Érica Aranha Suzumura, Otavio Berwanger, P.J. Devereaux, Carisi A Polanczyk Background: Myocardial injury after noncardiac surgery (MINS) includes patients with traditional myocardial infarction and those with ischemic myocardial injury after surgery. This study evaluated the prognostic value of MINS on major cardiovascular events and 30-day mortality, and determined independent preoperative predictors of MINS in patients after noncardiac surgery.Methods: This multicenter prospective cohort study was part of the VISION Study. The sample consisted of 2,504 patients who underwent noncardiac surgery at two tertiary hospitals in Brazil between September 2008 and July 2012. Troponin Ts were measured 6-12 hours, and on days 1, 2, and 3 after surgery. Cox regression analyses were performed to identify independent variables of major outcomes.Results: A total of 314 (13%) patients were diagnosed with MINS, of which 26 (8%) died. Length-of-hospital stay of MINS patients was three times higher (18±22 days vs. 5.8±11 days). In multivariate analysis, 30-day mortality was significantly higher among patients with MINS (hazard ratio [HR] 3.17 (95% CI 1.56-6.41)), and major bleeding (HR 5.76 (95% CI 2.75-12.05)), sepsis (HR 5.08 (95% CI 2.25-11.46)), active cancer (HR 4.22 (95% CI 1.98- 8.98)) and general surgery (HR 3.11 (95% CI 1.51-6.41)). Multivariable analysis indicated a higher chance of MINS in patients ≥75 years of age, history of diabetes mellitus, hypertension, heart failure, coronary disease, and end-stage renal failure.Conclusion: The incidence of MINS within 30 days after noncardiac surgery is related to higher mortality. Postoperative troponin monitoring in elder patients and with risk factors for atherosclerotic disease may help reduce postoperative cardiovascular events.
       
  • Mechanistic insights to target atherosclerosis residual risk
    • Abstract: Publication date: Available online 24 June 2019Source: Current Problems in CardiologyAuthor(s): Mohammad Alkhalil Current pharmacological and mechanical therapies have reduced future cardiovascular risk. Nonetheless, a significant proportion of patients remained at high risk of recurrent events despite achieving guideline-directed therapeutic targets. This residual risk poses challenges despite tackling ‘traditional’ risk factors. Targeting the residual risk has been the focus of numerous pharmacotherapies which were associated with variable success. Incomplete understanding of the mechanistic nature combined with the lack of tools to precisely quantify the residual risk contributed to the relatively high residual risk after ‘optimal’ medical therapy.The development of atherosclerotic plaque is derived from lipid retention within arterial intima that triggers an inflammatory cascade accelerating atherosclerosis progression and rendering plaque more prone to rupture. The exposed subendothelial space with activated platelets causes arterial occlusion leading to potential fatality. Therefore, a distinctive approach to characterise these features may offer the opportunity to tailor novel anti-atherosclerotic to reduce the residual risk. The traditional approach of measuring risk factors is beneficial at population-level but maybe less informative upon quantifying risk at an individual-basis.This review will discuss lipid accumulation, thrombosis, and inflammation as therapeutic targets of atherosclerosis. Additionally, we will summarise previous challenges of anti-atherosclerosis therapies and the future role to tackle the residual risk.
       
  • Serum Bilirubin and Coronary Artery Disease: Intricate Relationship,
           Pathophysiology and Recent Evidence
    • Abstract: Publication date: Available online 22 June 2019Source: Current Problems in CardiologyAuthor(s): Vardhmaan Jain, Raktim K. Ghosh, Dhrubajyoti Bandyopadhyay, Meera Kondapaneni, Samhati Mondal, Adrija Hajra, Wilbert S. Aronow, Carl J. Lavie Coronary artery disease (CAD) is a major cause of morbidity, mortality and healthcare expenditure. A number of environmental and genetic risk factors have been known to contribute to CAD. More recently, a number of studies have supported as well as opposed a possible protective benefit of Bilirubin in CAD, since it has anti-inflammatory, antioxidant, and anti-aggregatory properties that may reduce atherogenesis. It also shares associations with different forms of CAD, namely stable CAD, unstable angina pectoris, stable angina pectoris, and acute myocardial infarction. Lack of sufficient evidence, however, has failed to elucidate a causal relationship between serum bilirubin level and risk of CAD. Therefore, in this update, we attempted to simplify this intricate relationship between bilirubin and CAD, revisit the pathophysiology of disease, how bilirubin may be protective, and to summarize the findings of the current literature.
       
  • ETRIPAMIL: INTRANASAL CALCIUM CHANNEL BLOCKER: A NOVEL NON-INVASIVE
           MODALITY IN THE TREATMENT OF PAROXYSMAL SUPRA-VENTRICULAR TACHYCARDIA.
    • Abstract: Publication date: Available online 22 June 2019Source: Current Problems in CardiologyAuthor(s): Joel M. Raja, Brandon Cave, John L. Jefferies, Rami N. Khouzam
       
  • Risk Stratification in Bicuspid Aortic Valve Aortopathy: Emerging Evidence
           and Future Perspectives
    • Abstract: Publication date: Available online 21 June 2019Source: Current Problems in CardiologyAuthor(s): Alessandro Della Corte, Hector I. Michelena, Angelo Citarella, Emiliano Votta, Filippo Piatti, Federica Lo Presti, Rasul Ashurov, Marilena Cipollaro, Amalia Forte The current management of aortic dilatation associated with congenital bicuspid aortic valve (BAV aortopathy) is based on dimensional parameters (diameter of the aneurysm, growth of the diameter over time) and few other criteria. The disease is however heterogeneous in terms of natural and clinical history and risk of acute complications, i.e. aortic dissection. Dimensional criteria are now admitted to have limited value as predictors of such complications. Thus, novel principles for risk stratification have been recently investigated, including phenotypic criteria, flow-related metrics and circulating biomarkers. A systematization of the typical anatomo-clinical forms that the aortopathy can assume has led to the identification of the more severe root phenotype, associated with higher risk of progression of the aneurysm and possible higher aortic dissection risk. Four-dimensional-flow magnetic resonance imaging studies are searching for potentially clinically significant metrics of flow derangement, based on the recognized association of local abnormal shear stress with wall pathology. Other research initiatives are addressing the question whether circulating molecules could predict the presence or, more importantly, the future development of aortopathy. The present review summarizes the latest progresses in the knowledge on risk stratification of BAV aortopathy, focusing on critical aspects and debated points.
       
  • Factors Affecting Early Mortality and 1-Year Outcomes in Young Women With
           ST-Segment-Elevation Myocardial Infarction Aged Less Than or Equal to 45
           Years
    • Abstract: Publication date: Available online 30 March 2019Source: Current Problems in CardiologyAuthor(s): Maciej Bęćkowski, Marek Gierlotka, Mariusz Gąsior, Lech Poloński, Tomasz Zdrojewski, Rafał Dąbrowski, Ilona Kowalik, Jarosław Karwowski, Wojciech Drygas, Hanna Szwed Given that up to 2% of patients with myocardial infarction (MI) are young women, the purpose of this study was to evaluate factors affecting outcomes in young women with ST-segment-elevation myocardial infarction (STEMI) aged less than or equal to 45 years. We evaluated 796 women with STEMI aged less than or equal to 45 years between 2007 and 2014, and mortality was 4.0%. Death occurred more often in women with prehospital sudden cardiac arrest, and severe symptoms of heart failure; less commonly, the women were subjected to percutaneous coronary intervention (PCI), with a higher rate of incomplete revascularization. Beta blockers (BB) and angiotensin converting enzyme inhibitors were frequently used in the survivor group. The independent predictor of 30-day mortality was as follows: inability to undergo PCI (odds ratio [OR] 4.6, 95% confidence interval [CI] 1.45-14.76, P = 0.009), sudden cardiac arrest (OR 4.5, 95% CI 1.5-18.3, P = 0.04). An increase in systolic blood pressure for every 5 mm Hg was associated with lower mortality, OR 0.90, 95% CI 0.76-0.97 in patients without cardiogenic shock (CS) and OR 0.69, 95% CI 0.61-0.78, P < 0.0001 in the group with CS. Predictors for 1-year mortality were the inability to undergo PCI (hazard ratio [HR] 84, 95% CI 1.6-43.1, P = 0.01) and CS (HR 6.97, 95% CI 1.39-34.7, P = 0.01). An increase of 5% in left ventricular ejection fraction reduced the mortality rate for 60% (HR 0.40, 95% CI 0.26-0.63, P < 0.0001) and an increase in systolic blood pressure for every 5 mm Hg reduced mortality for 34% (HR 0.66, 95% CI 0.52-0.84, P = 0.02). Both short- and long-term outcomes in young women aged less than or equal to 45 years with STEMI are good. The strongest predictor for both 30-day and 1-year mortality was the inability to undergo PCI. Suboptimal use of beta blockers and angiotensin converting enzyme inhibitors affect the outcomes in young women. Hypotension in the acute phase of MI increased mortality in young women, independent of coexisting CS.
       
  • AN EXPLORATORY LOOK AT BICUSPID AORTIC VALVE (BAV) AORTOPATHY: FOCUS ON
           MOLECULAR AND CELLULAR MECHANISMS
    • Abstract: Publication date: Available online 20 April 2019Source: Current Problems in CardiologyAuthor(s): Chiara Mozzini, Domenico Girelli, Luciano Cominacini, Maurizio Soresi Bicuspid aortic valve (BAV) is the most common congenital heart malformation.BAV patients are at increased risk for aortic valve disease (stenosis/regurgitation), infective endocarditis, thrombi formation and, in particular, aortic dilatation, aneurysm and dissection.This review aims at exploring the possible interplay among genetics, extracellular matrix (ECM) remodeling, abnormal signaling pathways, oxidative stress and inflammation in contributing to BAV-associated aortopathy (BAV-A-A).Novel circulating biomarkers have been proposed as diagnostic tools able to improve risk stratification in BAV-A-A. However, to date, the precise molecular and cellular mechanisms that lead to BAV-A-A remain unknown. Genetic, haemodynamic and cardiovascular risk factors have been implicated in the development and progression of BAV-A-A. Oxidative stress may also play a role, similarly to what observed in atherosclerosis and vulnerable plaque formation. The identification of common pathways between these two conditions may provide a platform for future therapeutic solutions.
       
  • Reference values for Neutrophil to Lymphocyte Ratio (NLR), a biomarker of
           cardiovascular risk, according to age and sex in a Latin American
           population
    • Abstract: Publication date: Available online 13 April 2019Source: Current Problems in CardiologyAuthor(s): Ezequiel Huguet, Gustavo Maccallini, Patricia Pardini, Mariana Hidalgo, Sebastián Obregon, Fernando Botto, Martin Koretzky, Peter M Nilsson, Keith Ferdinand, Carol Kotliar
       
  • A comparative analysis of mitraclip versus mitral valve-in-valve
           replacement for high risk patients with severe mitral regurgitation after
           transcatheter aortic valve replacement.
    • Abstract: Publication date: Available online 12 April 2019Source: Current Problems in CardiologyAuthor(s): Amit Nanda, Tamunoinemi Bob-Manuel, John Jefferries, Uzoma Ibebuogu, Rami N. Khouzam
       
  • Effects of breast cancer genes 1 and 2 on cardiovascular diseases
    • Abstract: Publication date: Available online 12 April 2019Source: Current Problems in CardiologyAuthor(s): Shanshan Zhou, Jingpeng Jin, Jiqun Wang, Zhiguo Zhang, Shanshan Huang, Yang Zheng, Lu Cai Carriers of mutations of breast cancer gene 1 and/or 2 (BRCA1/2) have a higher risk of developing breast and ovarian cancers at a relatively young age. Recently, a causative role for BRCA1/2 in cardiovascular diseases has been emerging. In this review, we summarize currently available evidence obtained from studies on animal models and human BRCA1/2 mutation carriers that shows a correlation of BRCA1/2 deficiency with various cardiovascular diseases, including ischemic heart disease, atherosclerosis, and chemotherapy-linked cardiac muscle disorders. We also discuss one of the major mechanisms by which BRCA1/2 protects the heart against oxidative stress, i.e. mediating the activity of Nrf2 and its downstream targets that govern antioxidant signaling. More research is needed to elucidate whether the carriers of the BRCA1/2 mutations with ovarian and breast cancers have increased susceptibility to chemotherapy-induced cardiac functional impairment.
       
  • Decompensated Heart Failure in Patients with Aortic Valve Stenosis
    • Abstract: Publication date: Available online 30 March 2019Source: Current Problems in CardiologyAuthor(s): María Luján Talavera, Juan Mariano Vrancic, Adriana Acosta, Luciano Battioni, Alfonsina Candiello, Rocío Baro, Lucrecia Burgos, Mirta Diez
       
  • Lean Mass Abnormalities in Heart Failure: The Role of Sarcopenia,
           Sarcopenic Obesity and Cachexia
    • Abstract: Publication date: Available online 28 March 2019Source: Current Problems in CardiologyAuthor(s): Salvatore Carbone, Hayley E. Billingsley, Paula Rodriguez Miguelez, Danielle L. Kirkman, Ryan Garten, R. Lee Franco, Duck-chul Lee, Carl J. Lavie The role of body composition in patients with heart failure (HF) has been receiving much attention in the last few years. Particularly, lean mass (LM), the best surrogate for skeletal muscle mass, is independently associated with cardiorespiratory fitness (CRF) and muscle strength, ultimately leading to reduced quality of life and worse prognosis. While in the past reduced CRF in patients with HF was thought to result exclusively from cardiac dysfunction leading to reduced cardiac output at peak exercise, current evidence supports the concept that abnormalities in LM may also play a critical role. Abnormalities in the LM body composition compartment are associated with the development of sarcopenia, sarcopenic obesity and cachexia. Such conditions have been implicated in the pathophysiology and progression of HF. However, identification of such conditions remains challenging, as universal definitions for sarcopenia, sarcopenic obesity and cachexia are lacking. In this review article, we describe the most common body composition abnormalities related to the LM compartment, including skeletal and respiratory muscle mass abnormalities, and the consequences of such anomalies on CRF and muscle strength in patients with HF. Finally, we discuss the potential non-pharmacologic therapeutic strategies such as exercise training (i.e., aerobic exercise and resistance exercise) and dietary interventions (i.e., dietary supplementation and dietary patterns) that have been implemented to target body composition, with a focus on HF.
       
  • Speckle Tracking Echocardiography in Non-ST-Segment Elevation Acute
           Coronary Syndromes
    • Abstract: Publication date: Available online 28 March 2019Source: Current Problems in CardiologyAuthor(s): D. Mele, F. Trevisan, A. D'Andrea, G.A. Luisi, V. Smarrazzo, G. Pestelli, F. Flamigni, R. FerrariABSTRACTNon ST-segment elevation acute coronary syndromes (NSTE-ACSs) are a group of clinical conditions characterized by acute myocardial ischemia. Conventional echocardiography is generally used to evaluate cardiac function using wall motion analysis and left ventricular ejection fraction but may be insufficient to explore all the complex features of NSTE-ACSs, which may vary substantially from patient to patient in terms of severity of ischemia and extent of involved myocardium. In the last years, speckle tracking echocardiography (STE) has become a widely available technique for the non-invasive assessment of cardiac function and has been repeatedly applied in the setting of NSTE-ACSs. In this review we summarize current evidence about the use of STE in patients with NSTE-ACSs, trying to underline advantages and limitations in comparison with conventional echocardiography for: diagnosis of NSTE-ACS, differential diagnosis, identification of high-risk patients, and prediction of outcome.
       
  • The Paradoxical Impact of Insurance Status on Inter-facility Transfer
           Times and Outcomes in Patients with ST-Elevation Myocardial Infarction
    • Abstract: Publication date: Available online 26 March 2019Source: Current Problems in CardiologyAuthor(s): Amit Nanda, Alex Urban, Vinh Duong, Mark Heckle, Uzoma N. Ibebuogu, Guy Reed, John Jefferies, Rami N. Khouzam
       
  • New Insights into the Comorbidity of Coronary Heart Disease and Depression
    • Abstract: Publication date: Available online 12 March 2019Source: Current Problems in CardiologyAuthor(s): Yeshun Wu, Bin Zhu, Zijun Chen, Jiahao Duan, Ailin Luo, Ling Yang, Chun Yang Coronary heart disease (CHD) and depression are common disorders that markedly impair quality of life and impose a great financial burden on society. They are also frequently comorbid, exacerbating patient condition and worsening prognosis. This comorbidity strongly suggests shared pathological mechanisms. This review focuses on the incidence of depression in patients with CHD, deleterious effects of depression on CHD symptoms, and the potential mechanisms underlying comorbidity. In addition to the existing frequent mechanisms that are well known for decades, this review summarized interesting and original potential mechanisms to underlie the comorbidity, such as endocrine substances, gut microbiome, and microRNA. Finally, there are several treatment strategies for the comorbidity, involving drugs and psychotherapy, which may provide a theoretical basis for further basic research and clinical investigations on improved therapeutic interventions.
       
 
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