Subjects -> MEDICAL SCIENCES (Total: 8359 journals)
    - ALLERGOLOGY AND IMMUNOLOGY (210 journals)
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CARDIOVASCULAR DISEASES (329 journals)                  1 2 | Last

Showing 1 - 200 of 329 Journals sorted alphabetically
Acta Angiologica     Open Access   (Followers: 5)
Acta Cardiologica     Hybrid Journal   (Followers: 2)
Acute Cardiac Care     Hybrid Journal   (Followers: 7)
Adipositas - Ursachen, Folgeerkrankungen, Therapie     Hybrid Journal  
AJP Heart and Circulatory Physiology     Hybrid Journal   (Followers: 12)
Aktuelle Kardiologie     Hybrid Journal   (Followers: 1)
American Heart Journal     Hybrid Journal   (Followers: 58)
American Journal of Cardiology     Hybrid Journal   (Followers: 67)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 17)
American Journal of Hypertension     Hybrid Journal   (Followers: 28)
Anales de Cirugia Vascular     Full-text available via subscription   (Followers: 1)
Anatolian Journal of Cardiology     Open Access   (Followers: 6)
Angiología     Full-text available via subscription  
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1)
Angiology     Hybrid Journal   (Followers: 3)
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (Followers: 1)
Annals of Noninvasive Electrocardiology     Hybrid Journal   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 12)
AORTA     Open Access  
Archives of Cardiovascular Diseases     Full-text available via subscription   (Followers: 5)
Archives of Cardiovascular Diseases Supplements     Full-text available via subscription   (Followers: 3)
Archives of Cardiovascular Imaging     Open Access   (Followers: 2)
Archivos de cardiología de México     Open Access   (Followers: 1)
Argentine Journal of Cardiology (English edition)     Open Access   (Followers: 2)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 1)
Arteriosclerosis, Thrombosis and Vascular Biology     Full-text available via subscription   (Followers: 32)
Artery Research     Hybrid Journal   (Followers: 4)
ARYA Atherosclerosis     Open Access  
ASAIO Journal     Hybrid Journal   (Followers: 3)
ASEAN Heart Journal     Open Access   (Followers: 2)
Asian Cardiovascular and Thoracic Annals     Hybrid Journal   (Followers: 2)
Aswan Heart Centre Science & Practice Services     Open Access   (Followers: 1)
Atherosclerosis : X     Open Access  
Bangladesh Heart Journal     Open Access   (Followers: 3)
Basic Research in Cardiology     Hybrid Journal   (Followers: 10)
BMC Cardiovascular Disorders     Open Access   (Followers: 22)
Brain Circulation     Open Access   (Followers: 1)
British Journal of Cardiology     Full-text available via subscription   (Followers: 16)
Canadian Journal of Cardiology     Hybrid Journal   (Followers: 18)
Cardiac Cath Lab Director     Full-text available via subscription  
Cardiac Electrophysiology Review     Hybrid Journal   (Followers: 2)
Cardiocore     Full-text available via subscription   (Followers: 1)
Cardiogenetics     Open Access   (Followers: 3)
Cardiology     Full-text available via subscription   (Followers: 20)
Cardiology and Angiology: An International Journal     Open Access   (Followers: 1)
Cardiology and Therapy     Open Access   (Followers: 12)
Cardiology Clinics     Full-text available via subscription   (Followers: 14)
Cardiology in Review     Hybrid Journal   (Followers: 8)
Cardiology in the Young     Hybrid Journal   (Followers: 34)
Cardiology Journal     Open Access   (Followers: 6)
Cardiology Plus     Open Access   (Followers: 1)
Cardiology Research     Open Access   (Followers: 15)
Cardiology Research and Practice     Open Access   (Followers: 10)
Cardiopulmonary Physical Therapy Journal     Hybrid Journal   (Followers: 7)
Cardiorenal Medicine     Full-text available via subscription   (Followers: 1)
Cardiothoracic Surgeon     Open Access   (Followers: 1)
CardioVasc     Full-text available via subscription   (Followers: 1)
Cardiovascular & Haematological Disorders - Drug Targets     Hybrid Journal   (Followers: 1)
Cardiovascular & Hematological Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 2)
CardioVascular and Interventional Radiology     Hybrid Journal   (Followers: 15)
Cardiovascular and Thoracic Open     Open Access  
Cardiovascular Diabetology     Open Access   (Followers: 10)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 14)
Cardiovascular Endocrinology & Metabolism     Hybrid Journal   (Followers: 1)
Cardiovascular Engineering     Hybrid Journal   (Followers: 1)
Cardiovascular Engineering and Technology     Hybrid Journal   (Followers: 1)
Cardiovascular Intervention and Therapeutics     Hybrid Journal   (Followers: 5)
Cardiovascular Journal     Open Access   (Followers: 6)
Cardiovascular Journal of Africa     Full-text available via subscription   (Followers: 5)
Cardiovascular Journal of South Africa     Full-text available via subscription   (Followers: 1)
Cardiovascular Medicine in General Practice     Full-text available via subscription   (Followers: 7)
Cardiovascular Pathology     Hybrid Journal   (Followers: 4)
Cardiovascular Regenerative Medicine     Open Access  
Cardiovascular Research     Hybrid Journal   (Followers: 15)
Cardiovascular Revascularization Medicine     Hybrid Journal   (Followers: 1)
Cardiovascular System     Open Access  
Cardiovascular Therapeutics     Open Access   (Followers: 1)
Cardiovascular Toxicology     Hybrid Journal   (Followers: 6)
Cardiovascular Ultrasound     Open Access   (Followers: 5)
Case Reports in Cardiology     Open Access   (Followers: 7)
Catheterization and Cardiovascular Interventions     Hybrid Journal   (Followers: 3)
Cerebrovascular Diseases     Full-text available via subscription   (Followers: 3)
Cerebrovascular Diseases Extra     Open Access  
Chest     Full-text available via subscription   (Followers: 100)
Choroby Serca i Naczyń     Open Access   (Followers: 1)
Circulation     Hybrid Journal   (Followers: 247)
Circulation : Cardiovascular Imaging     Hybrid Journal   (Followers: 15)
Circulation : Cardiovascular Interventions     Hybrid Journal   (Followers: 17)
Circulation : Cardiovascular Quality and Outcomes     Hybrid Journal   (Followers: 11)
Circulation : Genomic and Precision Medicine     Hybrid Journal   (Followers: 15)
Circulation : Heart Failure     Hybrid Journal   (Followers: 26)
Circulation Research     Hybrid Journal   (Followers: 36)
Cirugía Cardiovascular     Open Access  
Clínica e Investigación en Arteriosclerosis     Full-text available via subscription  
Clínica e Investigación en arteriosclerosis (English Edition)     Hybrid Journal  
Clinical and Experimental Hypertension     Hybrid Journal   (Followers: 3)
Clinical Cardiology     Hybrid Journal   (Followers: 11)
Clinical Hypertension     Open Access   (Followers: 5)
Clinical Medicine Insights : Cardiology     Open Access   (Followers: 6)
Clinical Research in Cardiology     Hybrid Journal   (Followers: 6)
Clinical Research in Cardiology Supplements     Hybrid Journal  
Clinical Trials and Regulatory Science in Cardiology     Open Access   (Followers: 4)
Congenital Heart Disease     Hybrid Journal   (Followers: 6)
Congestive Heart Failure     Hybrid Journal   (Followers: 4)
Cor et Vasa     Full-text available via subscription   (Followers: 1)
Coronary Artery Disease     Hybrid Journal   (Followers: 2)
CorSalud     Open Access  
Critical Pathways in Cardiology     Hybrid Journal   (Followers: 4)
Current Cardiology Reports     Hybrid Journal   (Followers: 7)
Current Cardiology Reviews     Hybrid Journal   (Followers: 4)
Current Cardiovascular Imaging Reports     Hybrid Journal   (Followers: 1)
Current Cardiovascular Risk Reports     Hybrid Journal  
Current Heart Failure Reports     Hybrid Journal   (Followers: 5)
Current Hypertension Reports     Hybrid Journal   (Followers: 6)
Current Hypertension Reviews     Hybrid Journal   (Followers: 6)
Current Opinion in Cardiology     Hybrid Journal   (Followers: 14)
Current Problems in Cardiology     Hybrid Journal   (Followers: 3)
Current Research : Cardiology     Full-text available via subscription   (Followers: 1)
Current Treatment Options in Cardiovascular Medicine     Hybrid Journal   (Followers: 1)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 5)
CVIR Endovascular     Open Access   (Followers: 1)
Der Kardiologe     Hybrid Journal   (Followers: 2)
Echo Research and Practice     Open Access   (Followers: 2)
Echocardiography     Hybrid Journal   (Followers: 4)
Egyptian Heart Journal     Open Access   (Followers: 2)
Egyptian Journal of Cardiothoracic Anesthesia     Open Access  
ESC Heart Failure     Open Access   (Followers: 4)
European Heart Journal     Hybrid Journal   (Followers: 67)
European Heart Journal - Cardiovascular Imaging     Hybrid Journal   (Followers: 10)
European Heart Journal - Cardiovascular Pharmacotherapy     Full-text available via subscription   (Followers: 3)
European Heart Journal - Quality of Care and Clinical Outcomes     Hybrid Journal  
European Heart Journal : Acute Cardiovascular Care     Hybrid Journal   (Followers: 1)
European Heart Journal : Case Reports     Open Access   (Followers: 1)
European Heart Journal Supplements     Hybrid Journal   (Followers: 8)
European Journal of Cardio-Thoracic Surgery     Hybrid Journal   (Followers: 9)
European Journal of Cardio-Thoracic Surgery Supplements     Full-text available via subscription   (Followers: 2)
European Journal of Cardiovascular Nursing     Hybrid Journal   (Followers: 5)
European Journal of Heart Failure     Hybrid Journal   (Followers: 14)
European Journal of Preventive Cardiology.     Hybrid Journal   (Followers: 6)
European Stroke Organisation     Hybrid Journal   (Followers: 3)
Experimental & Translational Stroke Medicine     Open Access   (Followers: 8)
Expert Review of Cardiovascular Therapy     Full-text available via subscription   (Followers: 3)
Folia Cardiologica     Open Access  
Forum Zaburzeń Metabolicznych     Hybrid Journal  
Frontiers in Cardiovascular Medicine     Open Access   (Followers: 1)
Future Cardiology     Hybrid Journal   (Followers: 6)
General Thoracic and Cardiovascular Surgery     Hybrid Journal   (Followers: 3)
Global Cardiology Science and Practice     Open Access   (Followers: 5)
Global Heart     Hybrid Journal   (Followers: 3)
Heart     Hybrid Journal   (Followers: 48)
Heart and Mind     Open Access  
Heart and Vessels     Hybrid Journal  
Heart Failure Clinics     Full-text available via subscription   (Followers: 2)
Heart Failure Reviews     Hybrid Journal   (Followers: 3)
Heart India     Open Access   (Followers: 2)
Heart International     Full-text available via subscription  
Heart Rhythm     Hybrid Journal   (Followers: 11)
Heart Views     Open Access   (Followers: 2)
HeartRhythm Case Reports     Open Access  
Hellenic Journal of Cardiology     Open Access   (Followers: 1)
Herz     Hybrid Journal   (Followers: 3)
High Blood Pressure & Cardiovascular Prevention     Full-text available via subscription   (Followers: 2)
Hypertension     Full-text available via subscription   (Followers: 23)
Hypertension in Pregnancy     Hybrid Journal   (Followers: 9)
Hypertension Research     Hybrid Journal   (Followers: 5)
Ibrahim Cardiac Medical Journal     Open Access  
IJC Heart & Vessels     Open Access   (Followers: 1)
IJC Heart & Vasculature     Open Access   (Followers: 1)
IJC Metabolic & Endocrine     Open Access   (Followers: 1)
Indian Heart Journal     Open Access   (Followers: 5)
Indian Journal of Cardiovascular Disease in Women WINCARS     Open Access  
Indian Journal of Thoracic and Cardiovascular Surgery     Hybrid Journal  
Indian Pacing and Electrophysiology Journal     Open Access   (Followers: 1)
Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery     Hybrid Journal   (Followers: 1)
Insuficiencia Cardíaca     Open Access  
Interactive CardioVascular and Thoracic Surgery     Hybrid Journal   (Followers: 7)
International Cardiovascular Forum Journal     Open Access  
International Journal of Angiology     Hybrid Journal   (Followers: 2)
International Journal of Cardiology     Hybrid Journal   (Followers: 18)
International Journal of Cardiovascular and Cerebrovascular Disease     Open Access   (Followers: 2)
International Journal of Cardiovascular Imaging     Hybrid Journal   (Followers: 2)
International Journal of Cardiovascular Research     Hybrid Journal   (Followers: 6)
International Journal of Heart Rhythm     Open Access  
International Journal of Hypertension     Open Access   (Followers: 8)
International Journal of Hyperthermia     Open Access  
International Journal of Stroke     Hybrid Journal   (Followers: 30)
International Journal of the Cardiovascular Academy     Open Access  
Interventional Cardiology Clinics     Full-text available via subscription   (Followers: 2)
Interventional Cardiology Review     Full-text available via subscription  
JACC : Basic to Translational Science     Open Access   (Followers: 5)
JACC : Cardiovascular Imaging     Hybrid Journal   (Followers: 18)
JACC : Cardiovascular Interventions     Hybrid Journal   (Followers: 17)
JACC : Heart Failure     Full-text available via subscription   (Followers: 14)
JAMA Cardiology     Hybrid Journal   (Followers: 28)
JMIR Cardio     Open Access  
Jornal Vascular Brasileiro     Open Access  
Journal of Clinical & Experimental Cardiology     Open Access   (Followers: 5)
Journal of Arrhythmia     Open Access  
Journal of Cardiac Critical Care TSS     Open Access   (Followers: 1)
Journal of Cardiac Failure     Hybrid Journal   (Followers: 1)

        1 2 | Last

Similar Journals
Journal Cover
IJC Metabolic & Endocrine
Journal Prestige (SJR): 0.4
Citation Impact (citeScore): 1
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2214-7624
Published by Elsevier Homepage  [3161 journals]
  • Effects of dipeptidyl peptidase-4 inhibitor sitagliptin on coronary
           atherosclerosis as assessed by intravascular ultrasound in type 2 diabetes
           mellitus with coronary artery disease

    • Authors: Yuta Kato; Atsushi Iwata; Bo Zhang; Shin-ichiro Miura; Satoshi Imaizumi; Takashi Kuwano; Amane Ike; Makoto Sugihara; Hiroaki Nishikawa; Shin'ichiro Yasunaga; Keijiro Saku
      Pages: 1 - 9
      Abstract: Publication date: September 2017
      Source:IJC Metabolic & Endocrine, Volume 16
      Author(s): Yuta Kato, Atsushi Iwata, Bo Zhang, Shin-ichiro Miura, Satoshi Imaizumi, Takashi Kuwano, Amane Ike, Makoto Sugihara, Hiroaki Nishikawa, Shin'ichiro Yasunaga, Keijiro Saku
      Background It is unclear whether the addition of dipeptidyl peptidase-4 inhibitors (DPP4-I) to statins may cause coronary plaque regression in type 2 diabetes mellitus (T2DM) patients with coronary artery disease (CAD). Methods and results Seventy-five T2DM patients with CAD who underwent percutaneous coronary intervention under intravascular ultrasound (IVUS) guidance were randomized to receive DPP4-I sitagliptin (sitagliptin group) or not to receive DPP4-I (non-DPP4-I group) as an add-on treatment to statins, and were followed-up for 8–12months. Patients with analyzable IVUS examinations of the non-culprit segment were included in the primary analysis. Sitagliptin group (n =28) and non-DPP4-I group (n =24) had significant (p <0.05) and similar reduction in low-density lipoprotein cholesterol levels (−12±24 and −12±23mg/dL), and had no significant changes in hemoglobin A1c levels. Nominal change in percent atheroma volume (PAV), the primary endpoint, was not significant in both the sitagliptin and non-DPP4-I groups [mean (95% CI): +1.1% (−0.5 to 2.7%) and 0.2% (−1.5 to 1.9%)]. The difference in change in PAV between sitagliptin and non-DPP4-I groups was also not significant [0.89% (−1.46%–3.25%)]. Conclusions The addition of sitagliptin to statins did not cause coronary plaque regression in T2DM with CAD.
      Graphical abstract image

      PubDate: 2017-06-22T22:26:07Z
      DOI: 10.1016/j.ijcme.2017.06.005
      Issue No: Vol. 16 (2017)
       
  • Upgrade system device in use of new oral anticoagulants vs. antiplatelet
           agents

    • Authors: Márcio Galindo Kiuchi; Shaojie Chen
      Pages: 10 - 11
      Abstract: Publication date: September 2017
      Source:IJC Metabolic & Endocrine, Volume 16
      Author(s): Márcio Galindo Kiuchi, Shaojie Chen


      PubDate: 2017-06-22T22:26:07Z
      DOI: 10.1016/j.ijcme.2017.06.006
      Issue No: Vol. 16 (2017)
       
  • Long-term follow-up of rivaroxaban use in Japanese patients with
           non-valvular atrial fibrillation

    • Authors: Makoto Suzuki; Akira Mizukami; Shunsuke Kuroda; Maki Ohno; Ryota Iwatsuka; Akihiko Matsumura; Yuji Hashimoto
      Pages: 12 - 14
      Abstract: Publication date: September 2017
      Source:IJC Metabolic & Endocrine, Volume 16
      Author(s): Makoto Suzuki, Akira Mizukami, Shunsuke Kuroda, Maki Ohno, Ryota Iwatsuka, Akihiko Matsumura, Yuji Hashimoto


      PubDate: 2017-06-22T22:26:07Z
      DOI: 10.1016/j.ijcme.2017.06.004
      Issue No: Vol. 16 (2017)
       
  • Always think of medications

    • Authors: Muhammad Munir Babar
      First page: 15
      Abstract: Publication date: September 2017
      Source:IJC Metabolic & Endocrine, Volume 16
      Author(s): Muhammad Munir Babar


      PubDate: 2017-07-12T06:23:16Z
      DOI: 10.1016/j.ijcme.2017.06.008
      Issue No: Vol. 16 (2017)
       
  • Statins use and the risk of liver dysfunction: A Chinese cohort study in
           real world clinical practice

    • Authors: Ying Gao; Yao Wang; Na-Qiong Wu; Cheng-Gang Zhu; Yuan-Lin Guo; Ping Qing; Geng Liu; Qian Dong; Jian-Jun Li
      Pages: 16 - 20
      Abstract: Publication date: September 2017
      Source:IJC Metabolic & Endocrine, Volume 16
      Author(s): Ying Gao, Yao Wang, Na-Qiong Wu, Cheng-Gang Zhu, Yuan-Lin Guo, Ping Qing, Geng Liu, Qian Dong, Jian-Jun Li
      Background The risk of liver injury is greatly of concern in China due to higher prevalence of hepatitis. In this study, we evaluated the association between the use of statins and the elevation of aminotransferase (ALT) in “real-world” clinical practice. Methods 4489 patients were divided into statins group (62%) and no statins group (38%) according to their status of medications. Detections of ALT were performed within 24h after admission. The association of elevation of ALT and statins was analyzed. Results The percentage of patients with ALT>1×ULN(Upper Limit of Normal), was higher in statins group than that in no statins group (OR=1.27, 95%CI 1.08–1.493), but after adjusting risk factors the OR value was 1.043(95%CI 0.851–1.278) with no statistical difference. Similarly, no differences were found regarding percentages of patients with ALT>3×ULN. Types of statins were usual in clinical practice and dosages of statins used were moderate in >90% of patient. We failed to find differences among the types and the dosage of statins except lovastatin. In addition, the relation of statin use duration to elevated ALT was evaluated. The higher proportion of elevated ALT in patients with stain use <1month was detected compared those with stain use ≥3months (OR=1.408, 95%CI 1.111–1.783). Conclusion The data, firstly, provided two important information regarding the real status of liver dysfunction in Chinese patients who used moderate statins: 1) no relations between statin variety and ALT elevation; 2)statin-induced liver dysfunction frequently found in <1month. Further study may be needed to confirm our findings.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2017.06.003
      Issue No: Vol. 16 (2017)
       
  • Predictors for high incidence of premature ventricular contractions in
           chronic kidney disease patients

    • Authors: Márcio Galindo Kiuchi; Shaojie Chen
      Pages: 21 - 23
      Abstract: Publication date: September 2017
      Source:IJC Metabolic & Endocrine, Volume 16
      Author(s): Márcio Galindo Kiuchi, Shaojie Chen


      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2017.06.007
      Issue No: Vol. 16 (2017)
       
  • Pulmonary vein reconnection in patients with and without CKD

    • Authors: Márcio Galindo Kiuchi; Shaojie Chen
      Pages: 1 - 3
      Abstract: Publication date: June 2017
      Source:IJC Metabolic & Endocrine, Volume 15
      Author(s): Márcio Galindo Kiuchi, Shaojie Chen


      PubDate: 2017-04-12T06:39:18Z
      DOI: 10.1016/j.ijcme.2017.03.002
      Issue No: Vol. 15 (2017)
       
  • Beyond Beck's triad: A case report of cardiac tamponade in a
           “super-super” obese patient

    • Authors: Jiandong Zhang; Yuxuan Mao
      Pages: 4 - 5
      Abstract: Publication date: June 2017
      Source:IJC Metabolic & Endocrine, Volume 15
      Author(s): Jiandong Zhang, Yuxuan Mao


      PubDate: 2017-04-26T11:14:13Z
      DOI: 10.1016/j.ijcme.2017.03.001
      Issue No: Vol. 15 (2017)
       
  • Influence of vitamin D on the percentage time of cardiac resynchronization
           in patients with heart failure, premature ventricular complexes, and
           chronic kidney disease

    • Authors: Márcio Galindo Kiuchi; Luis Marcelo Rodrigues Paz; Shaojie Chen; Neil Alexander Hoye
      Pages: 6 - 9
      Abstract: Publication date: June 2017
      Source:IJC Metabolic & Endocrine, Volume 15
      Author(s): Márcio Galindo Kiuchi, Luis Marcelo Rodrigues Paz, Shaojie Chen, Neil Alexander Hoye


      PubDate: 2017-06-12T19:12:46Z
      DOI: 10.1016/j.ijcme.2017.06.001
      Issue No: Vol. 15 (2017)
       
  • Statins usage and target achievement of LDL-C level in Chinese patients
           with coronary artery disease impacted by 2013 ACC/AHA cholesterol
           guideline

    • Authors: Na-Qiong Wu; Yuan-Lin Guo; Ping Ye; Hong Chen; Yan-Fang Li; Qi Hua; Cheng-Gang Zhu; Ying Gao; Ping Qing; Xiao-Lin Li; Yao Wang; Geng Liu; Qian Dong; Jian-Jun Li
      Pages: 33 - 37
      Abstract: Publication date: March 2017
      Source:IJC Metabolic & Endocrine, Volume 14
      Author(s): Na-Qiong Wu, Yuan-Lin Guo, Ping Ye, Hong Chen, Yan-Fang Li, Qi Hua, Cheng-Gang Zhu, Ying Gao, Ping Qing, Xiao-Lin Li, Yao Wang, Geng Liu, Qian Dong, Jian-Jun Li
      Background Hypercholesterolemia is the accepted causal risk factor for atherosclerotic cardiovascular disease (ASCVD). 2013 ACC/AHA guideline on the treatment of cholesterol advised to tailor high-intensity statin for patients with coronary artery disease (CAD). However, its impact of real clinical practice has not been examined in China. Methods In this cross-sectional study, 3592 patients with CAD were consecutively enrolled who were receiving statins in outpatient department (at least 4weeks) before they were admitted to the ward at five University hospitals from April 2011 to December 2015. Patients were divided into two groups according to the admission time before (group A, n=1521) or after (group B, n=2071) online announcement date of 2013 ACC/AHA guideline. The situation of statin application and LDL-C target achievement (LDL-C<1.8mmol/L) in both groups were compared. Results Data indicated that the constituent ratio of different kinds of statins usage was significantly different between the two groups (p<0.05), and the proportion of rosuvastatin application grew up in group B (20.00%) when compared with group A (10.50%, p<0.05). However, the mean dosage of atorvastatin or rosuvastatin had no significant change. More importantly, the achievement of LDL-C target in both groups was still extremely low (27.9% in group A vs. 26.9% in group B, p=0.5077). Conclusion No much change of clinical practice with regard to cholesterol management was found in Chinese patients with CAD, accompanied by very low achievement of LDL-C target, suggesting that there is a great room for the improvement of cholesterol control in Chinese patients with CAD.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.11.002
      Issue No: Vol. 14 (2017)
       
  • Plasma free fatty acids in relation with the severity of coronary artery
           disease in non-diabetics: A Gensini score assessment

    • Authors: Jing-Lu Jin; Yuan-Lin Guo; Jian-Jun Li
      Pages: 48 - 52
      Abstract: Publication date: March 2017
      Source:IJC Metabolic & Endocrine, Volume 14
      Author(s): Jing-Lu Jin, Yuan-Lin Guo, Jian-Jun Li
      Objectives Free fatty acids (FFAs) have been reported to be a marker in the development of atherosclerosis. However, no data is currently available with regard to the relation of FFA to the severity of atherosclerosis. The aim of the present study was to evaluate the relation of free fatty acids levels to the severity of coronary artery disease (CAD) in non-diabetic patients. Methods A total of 766 consecutive individuals (496 CAD and 266 controls) who had a angina-like chest pain and received coronary angiography were enrolled in the study. FFA was measured using enzymatic assay and the severity of coronary arteries was assessed by Gensini score system. The association of plasma FFAs levels with the severity of CAD was finally investigated. Results There were significantly higher FFAs levels in CAD group compared with those in control group (p=0.040). FFAs levels were positively correlated with Gensini score (r=0.120, p=0.008) and elevated according to the tertiles of Gensini score (p for trend 0.002). Multivariate leaner regression analysis also proved that FFAs levels were independently associated with the Gensini score (β=0.106, p=0.018) after adjusting for traditional cardiovascular risk factors. Conclusions The present study showed that FFAs levels were positively and independently associated with the severity of CAD, suggested that further study may be needed to confirm our findings.

      PubDate: 2017-01-07T08:53:48Z
      DOI: 10.1016/j.ijcme.2016.12.004
      Issue No: Vol. 14 (2017)
       
  • Influence of vitamin D levels on the treatment of premature ventricular
           complexes in patients with chronic kidney disease

    • Authors: Márcio Galindo Kiuchi; Gustavo Ramalho e Silva; Luis Marcelo Rodrigues Paz; Shaojie Chen; Neil Alexander Hoye; Gladyston Luiz Lima Souto
      Pages: 53 - 58
      Abstract: Publication date: March 2017
      Source:IJC Metabolic & Endocrine, Volume 14
      Author(s): Márcio Galindo Kiuchi, Gustavo Ramalho e Silva, Luis Marcelo Rodrigues Paz, Shaojie Chen, Neil Alexander Hoye, Gladyston Luiz Lima Souto
      Introduction Recent studies have shown that in chronic kidney disease (CKD) 25(OH)D deficiency or insufficiency is a significant risk factor for cardiovascular diseases (CVDs), sudden cardiac death (SCD) and mortality. Premature ventricular complexes (PVCs) are very common in patients with CKD, hypertension, obesity, sleep apnea, and structural heart disease. Often PVCs in the structurally normal heart are considered benign, although they seem to be associated with a more than two-fold higher risk of cardiovascular complications, including stroke disease and death. Aim In the present study we aimed to evaluate the influence of different 25(OH)D levels on the changes of the numbers of PVCs in all patients, assessed by 24-hour-Holter monitoring 3months after β-blocker onset. Methods and results We conducted a prospective, longitudinal study of 824 patients with PVCs and CKD (estimated glomerular filtration rate measured by MDRD equation, between 16 and 59mL/min/1.73m2). All patients were treated with a β-blocker (bisoprolol 10mg daily). We observed that the 3 groups presented a significant decrease in the number of PVCs from baseline 26,091±3327 (25(OH)D deficiency group), 25,902±3501 (25(OH)D insufficiency group), and 25,554±3637 (25(OH)D sufficiency group) to 20,554±3782, 19,885±3945 and 15,433±4059, respectively, after 3months of β-blocker therapy (P <0.0001 for the comparisons between time points in the same group). However at the 3rd month after bisoprolol onset, comparisons between 25(OH)D deficiency vs. 25(OH)D sufficiency groups showed a mean difference of 5121 PVCs (P <0.0001), and comparisons between 25(OH)D insufficiency vs. 25(OH)D sufficiency groups showed a mean difference of 4452 PVCs (P <0.0001). No difference was observed between 25(OH)D deficiency vs. 25(OH)D insufficiency groups (P =0.3181). Conclusions We suggest that the effectiveness of β-blocker treatment for PVCs in CKD patients was observed in all 25(OH)D levels. However, the responsiveness was higher in patients with a normal range of 25(OH)D in comparison to patients with deficiency or insufficiency in 25(OH)D levels. Whether vitamin D supplementation increases the efficacy of beta-blocker mediated suppression of PVCs requires further evaluation.

      PubDate: 2017-01-07T08:53:48Z
      DOI: 10.1016/j.ijcme.2017.01.002
      Issue No: Vol. 14 (2017)
       
  • Prevention of Adriamycin induced cardiotoxicity in rats — A comparative
           study with subacute angiotensin-converting enzyme inhibitor and
           nonselective beta blocker therapy

    • Authors: Ajay Godwin Potnuri; Sundar Kumar Kondru; Pavan Kumar Samudrala; Lingesh Allakonda
      Pages: 59 - 64
      Abstract: Publication date: March 2017
      Source:IJC Metabolic & Endocrine, Volume 14
      Author(s): Ajay Godwin Potnuri, Sundar Kumar Kondru, Pavan Kumar Samudrala, Lingesh Allakonda
      Back ground Cardiotoxicity confines the usage of Adriamycin in clinical practice as it can develop cardiac impediments up to 10years after the termination of therapy. Even though, no specific therapeutic strategies are available for treating adriamycin-induced cardiotoxicity, beta-adrenergic blockers (βB) and angiotensin-converting enzyme (ACE) inhibitors are known to prevent its progression into failure. In this scenario, we attempted to compare the pharmacological outcome of sub-acute βB and ACE inhibitor treatments in preventing adriamycin-induced cardiotoxicity by analysing the differences between them. Methods Rats received a single bolus dose of adriamycin (10mg/kg) on day one and treated with either Carvedilol (10mg/kg) (CAR) or Captopril (50mg/kg) (CAP) once daily for 28days. Cardiac morphology, systolic and diastolic functions were evaluated by 2D trans-thoracic echocardiography. Cardiac Troponin and Ck MB levels were measured to analyse the myocyte damage. Myocardial lipid peroxidation, IL1β levels and caspase 3 activity were evaluated as the markers of oxidative stress, inflammation and apoptosis respectively. Results Both treatments had reduced the adriamycin induced cardiotoxicity. Whereas CAP treatment showed a better reduction of inflammation, superior preservation of posterior wall architecture and enhanced improvement in relative wall thickness when compared to CAR. Oxidative stress, caspase 3 activity and markers of myocyte damage were better recovered with CAR treatment while other parameters were found to be identically attenuated. Conclusion The present study found an identical therapeutic outcome from ACE inhibition and β blockade with a better attenuation of inflammation and structural preservation with ACE inhibition and superior antioxidant and antiapoptotic effect with βB treatment.

      PubDate: 2017-01-15T09:30:30Z
      DOI: 10.1016/j.ijcme.2017.01.001
      Issue No: Vol. 14 (2017)
       
  • Prognostic value of VE/VCO2 and interleukin-6 in chronic heart failure
           subjects

    • Authors: Danielle Pereira; Victor Neves; Dayane Montemezzo; Verônica Parreira; Maria Clara Alencar; Liliane Mendes; Leani Pereira; Raquel Britto
      Pages: 65 - 66
      Abstract: Publication date: March 2017
      Source:IJC Metabolic & Endocrine, Volume 14
      Author(s): Danielle Pereira, Victor Neves, Dayane Montemezzo, Verônica Parreira, Maria Clara Alencar, Liliane Mendes, Leani Pereira, Raquel Britto


      PubDate: 2017-01-15T09:30:30Z
      DOI: 10.1016/j.ijcme.2017.01.003
      Issue No: Vol. 14 (2017)
       
  • The effect of oxygen on the outcomes of non-ST-segment elevation acute
           coronary syndromes

    • Authors: Fatemeh Heidari; Kobra Rahzani; Daryoush Iranpoor; Korosh Rezaee
      Pages: 67 - 71
      Abstract: Publication date: March 2017
      Source:IJC Metabolic & Endocrine, Volume 14
      Author(s): Fatemeh Heidari, Kobra Rahzani, Daryoush Iranpoor, Korosh Rezaee
      Background This study aims to investigate the effect of oxygen in patients with non-ST-segment elevation acute coronary syndromes(NSTE-ACS) and those without hypoxia. Methods In this clinical trial, the study population includes 72 patients (41 men and 31 women) aged 18 to 84years old who were admitted to the emergency ward, diagnosed with NSTE-ACS, and had oxygen saturation level above 90% at the time of admission. By using the random sampling methods, the patients were divided into two groups: the intervention group (36) and the control group (36). In addition to the usual treatment in the first 6h of admission to the emergency ward, the subjects in the intervention group received oxygen with nasal cannula at a rate of 4 to 6l per minute, whereas the control group was given the same treatment with room air. Then we compared the incidence of some outcomes in the two groups. Results The Mann–Whitney U test indicated no significant difference between the means of dysrhythmia (p =0.141) during the first 24h, troponin (p =0.911), left ventricular ejection fraction (p =0.419), frequency of angina (p =0.214), and consumption of opioid analgesics (p =0.297) during the second 24h and duration of hospitalization (p =0.887). Conclusion The use of supplemental oxygen (FiO2: 40–45%) has no significant impact on clinical outcomes in patients with NSTE-ACS without hypoxia. Therefore, it is recommended that its routine use in patients without hypoxia be limited.

      PubDate: 2017-01-15T09:30:30Z
      DOI: 10.1016/j.ijcme.2016.12.002
      Issue No: Vol. 14 (2017)
       
  • The correlation between heart rate variability and the voltage left
           ventricular mapping in patients with and without CKD

    • Authors: Márcio Galindo Kiuchi; Shaojie Chen
      Pages: 72 - 74
      Abstract: Publication date: March 2017
      Source:IJC Metabolic & Endocrine, Volume 14
      Author(s): Márcio Galindo Kiuchi, Shaojie Chen


      PubDate: 2017-01-22T10:03:38Z
      DOI: 10.1016/j.ijcme.2017.01.005
      Issue No: Vol. 14 (2017)
       
  • Homozygous familiar hypercholesterolemia in China: Case series from the
           national lipid clinics and literature review

    • Authors: Cheng-Gang Zhu; Sha Li; Zhi-Fu Wang; Kun-Lun Yin; Na-Qiong Wu; Yuan-Lin Guo; Ying Gao; Xiao-Lin Li; Ping Qing; Geng Liu; Qian Dong; Zhou Zhou; Jian-Jun Li
      Pages: 75 - 80
      Abstract: Publication date: March 2017
      Source:IJC Metabolic & Endocrine, Volume 14
      Author(s): Cheng-Gang Zhu, Sha Li, Zhi-Fu Wang, Kun-Lun Yin, Na-Qiong Wu, Yuan-Lin Guo, Ying Gao, Xiao-Lin Li, Ping Qing, Geng Liu, Qian Dong, Zhou Zhou, Jian-Jun Li
      Objective Familial hypercholesterolemia (FH), an autosomal dominant genetic disorder, is often diagnosed in young age and cholesterol accumulation in tissues produces common clinical manifestations including cutaneous xanthomas, premature atherosclerosis, and poor response to medical therapy. The main objective was to investigate the patients of hoFH from China. Patients Over the past 4years, a cohort of 8 patients with severe FH phenotype due to the characteristic cutaneous xanthomas and extremely high low density lipoprotein cholesterol (LDL-C) levels from the national lipid clinics were enrolled. Genotype information was obtained. Results Of them, 7 patients had severe coronary atherosclerosis, 6 had family history of hypercholesterolemia, 2 had family history of premature coronary atherosclerosis. The patients had untreated LDL-C of >13mmol/L, and received maximal medical therapy. Importantly but not surprisingly, the lipid profile was not significantly improved by the current available concomitant use of rosuvastatin and ezetimibe. In genetic analysis, all patients had the mutations responsible to the FH phenotype and showed to be more heterogeneous than their clinical phenotype. Conclusion In a conclusion, we found a relatively common recruitment of this type of patients in our hospital, which might have an important clinical implication for the identification and management of the patients with FH in China.

      PubDate: 2017-01-22T10:03:38Z
      DOI: 10.1016/j.ijcme.2017.01.004
      Issue No: Vol. 14 (2017)
       
  • Effects of standard treatment and renal sympathetic denervation in
           patients with controlled hypertension and variant angina

    • Authors: Márcio Galindo Kiuchi; Shaojie Chen
      Pages: 81 - 83
      Abstract: Publication date: March 2017
      Source:IJC Metabolic & Endocrine, Volume 14
      Author(s): Márcio Galindo Kiuchi, Shaojie Chen


      PubDate: 2017-01-29T14:01:36Z
      DOI: 10.1016/j.ijcme.2017.01.006
      Issue No: Vol. 14 (2017)
       
  • Aerobic exercise can ameliorate heart function in patients with myocardial
           infarction through up-regulating M3 receptor

    • Authors: Wang Chengji; Huang Shoujun
      Pages: 1 - 5
      Abstract: Publication date: December 2016
      Source:IJC Metabolic & Endocrine, Volume 13
      Author(s): Wang Chengji, Huang Shoujun
      Objective cardioprotective effect and mechanism of exercise training up-regulating the expression of M3 receptor on myocardial infarction. Methods 48 male Sprague-Dawley rats were randomly assigned to three groups (n=16, per group):control group (C), myocardial infarction group (MI), moderate-intensity aerobic exercise with myocardial infarction group (ME). Rats in C group were breed normally. MI was induced by ligation of the left anterior descending (LAD) coronary artery in MI group. Rats in ME group took treadmill exercise for 8weeks. after 1week post-operation. ME group running began at the speed of 10m/min for 5min, then accelerated from 3m/min to 16m/min. The total time of ME is 60min, 5d/week, for 8weeks. LVSP, LVEDP, ±dp/dtmax and the cardiac function changes were measured after training. Myocardial collagen fibers were observed histological section and Masson staining. The expression of myocardial M3 R was observed and analyzed by immunofluorescence. The myocardial protein content of M3 R, MEK1/2,P-ERK1/2,ERK1/2 and apoptosis related Bcl-2 and Bax was assayed by Western blot. Results Compared with the C group, MI increased CVF and LVEDP (P˂0.01), but decreased LVSP and −dp/dtmax (P˂0.01). After MI myocardial M3 positive staining, after MI M3 protein expression significantly higher compared with the C group (P˂0.01), MEK1/2,P-ERK1/2/ERK1/2 protein expression were significantly increased compared with the C group (P˂0.01, P˂0.01), after the MI the Bcl-2/Bax expression significantly reduced compared with the C group (P˂0.01). ME group CVF%, LVEDP significantly reduced compared with the MI group (P˂0.01), but −dp/dtmax significantly increased (P˂0.01). ME group was identified myocardial M3, compared with the MI group, M3 protein expression significantly increased (P˂0.01), but Bcl-2/Bax expression significantly reduced (P˂0.01). Conclusions moderate-intensity aerobic exercise can up-regulated the M3 R-MEK1/2-ERK1/2 signaling pathway, thus inhibit the apoptosis of myocardial cells, reduced myocardial interstitial fibrosis and promote cardiac function after MI.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.08.001
      Issue No: Vol. 13 (2017)
       
  • Net cholesterol efflux capacity of HDL enriched serum and coronary
           atherosclerosis in rheumatoid arthritis

    • Authors: Michelle J. Ormseth; Patricia G. Yancey; Suguru Yamamoto; Annette M. Oeser; Tebeb Gebretsadik; Ayumi Shintani; MacRae F. Linton; Sergio Fazio; Sean S. Davies; L. Jackson Roberts; Kasey C. Vickers; Paolo Raggi; Valentina Kon; C. Michael Stein
      Pages: 6 - 11
      Abstract: Publication date: December 2016
      Source:IJC Metabolic & Endocrine, Volume 13
      Author(s): Michelle J. Ormseth, Patricia G. Yancey, Suguru Yamamoto, Annette M. Oeser, Tebeb Gebretsadik, Ayumi Shintani, MacRae F. Linton, Sergio Fazio, Sean S. Davies, L. Jackson Roberts, Kasey C. Vickers, Paolo Raggi, Valentina Kon, C. Michael Stein
      Background/objectives Cardiovascular (CV) risk is increased in patients with rheumatoid arthritis (RA), but not fully explained by traditional risk factors such as LDL and HDL cholesterol concentrations. The cholesterol efflux capacity of HDL may be a better CV risk predictor than HDL concentrations. We hypothesized that HDL's cholesterol efflux capacity is impaired and inversely associated with coronary atherosclerosis in patients with RA. Methods We measured the net cholesterol efflux capacity of apolipoprotein B depleted serum and coronary artery calcium score in 134 patients with RA and 76 control subjects, frequency-matched for age, race and sex. The relationship between net cholesterol efflux capacity and coronary artery calcium score and other clinical variables of interest was assessed in patients with RA. Results Net cholesterol efflux capacity was similar among RA (median [IQR]: 34% removal [28, 41%]) and control subjects (35% removal [27%, 39%]) (P=0.73). In RA, increasing net cholesterol efflux capacity was not significantly associated with decreased coronary calcium score (OR=0.78 (95% CI 0.51–1.19), P=0.24, adjusted for age, race and sex, Framingham risk score and presence of diabetes). Net cholesterol efflux capacity was not significantly associated with RA disease activity score, C-reactive protein, urinary F2-isoprostanes, or degree of insulin resistance in RA. Conclusions Net cholesterol efflux capacity is not significantly altered in patients with relatively well-controlled RA nor is it significantly associated with coronary artery calcium score.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.08.002
      Issue No: Vol. 13 (2017)
       
  • Pulmonary vein isolation alone and combined with renal sympathetic
           denervation in CKD patients with paroxysmal AF: A sub group analysis

    • Authors: Márcio Galindo Kiuchi; Shaojie Chen
      Pages: 12 - 14
      Abstract: Publication date: December 2016
      Source:IJC Metabolic & Endocrine, Volume 13
      Author(s): Márcio Galindo Kiuchi, Shaojie Chen


      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.09.002
      Issue No: Vol. 13 (2017)
       
  • Incidence of atrial fibrillation in patients with mild to severe
           obstructive sleep apnea and pacemakers

    • Authors: Márcio Galindo Kiuchi; Shaojie Chen
      Pages: 15 - 16
      Abstract: Publication date: December 2016
      Source:IJC Metabolic & Endocrine, Volume 13
      Author(s): Márcio Galindo Kiuchi, Shaojie Chen


      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.09.001
      Issue No: Vol. 13 (2017)
       
  • Electrical left ventricular mapping in patients with and without CKD:
           Differences of voltage

    • Authors: Márcio Galindo Kiuchi; Shaojie Chen
      Pages: 17 - 19
      Abstract: Publication date: December 2016
      Source:IJC Metabolic & Endocrine, Volume 13
      Author(s): Márcio Galindo Kiuchi, Shaojie Chen


      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.09.005
      Issue No: Vol. 13 (2017)
       
  • When the first and the second renal sympathetic denervation in resistant
           hypertensive patients failure: What to do'

    • Authors: Márcio Galindo Kiuchi; Shaojie Chen; Helmut Pürerfellner
      Pages: 20 - 22
      Abstract: Publication date: December 2016
      Source:IJC Metabolic & Endocrine, Volume 13
      Author(s): Márcio Galindo Kiuchi, Shaojie Chen, Helmut Pürerfellner


      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.09.006
      Issue No: Vol. 13 (2017)
       
  • Therapeutic impact of cardiac rehabilitation exercise on cardiac Fabry
           woman treated with enzyme replacement therapy

    • Authors: Hitomi Kitai; Etsushi Kyuno; Ayaka Nogi; Hideyuki Maezawa; Mio Ebato; Takeyuki Sambe; Hiroshi Suzuki; Yoshitaka Iso
      Pages: 23 - 25
      Abstract: Publication date: December 2016
      Source:IJC Metabolic & Endocrine, Volume 13
      Author(s): Hitomi Kitai, Etsushi Kyuno, Ayaka Nogi, Hideyuki Maezawa, Mio Ebato, Takeyuki Sambe, Hiroshi Suzuki, Yoshitaka Iso


      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.09.007
      Issue No: Vol. 13 (2017)
       
  • Non-invasive programmed stimulation vs. electrophysiological study in
           patients with pacemaker

    • Authors: Márcio Galindo Kiuchi; Shaojie Chen
      Pages: 26 - 27
      Abstract: Publication date: December 2016
      Source:IJC Metabolic & Endocrine, Volume 13
      Author(s): Márcio Galindo Kiuchi, Shaojie Chen


      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.10.001
      Issue No: Vol. 13 (2017)
       
  • Short-term caloric restriction in db/db mice improves myocardial function
           and increases high molecular weight (HMW) adiponectin

    • Authors: X. Julia Xu; Erma Babo; Fuzhong Qin; Dominique Croteau; Wilson S. Colucci
      Pages: 28 - 34
      Abstract: Publication date: December 2016
      Source:IJC Metabolic & Endocrine, Volume 13
      Author(s): X. Julia Xu, Erma Babo, Fuzhong Qin, Dominique Croteau, Wilson S. Colucci
      Background Obesity and metabolic syndrome lead to the development of metabolic heart disease (MHD) that is characterized by left ventricular hypertrophy (LVH), diastolic dysfunction, and increased mitochondrial ROS. Caloric restriction (CR) is a nutritional intervention that protects against obesity, diabetes, and cardiovascular disease. Healthy adipose tissue is cardioprotective via releasing adipokines such as adiponectin. We tested the hypothesis that CR can ameliorate MHD and it is associated with improved adipose tissue function as reflected by increased circulating levels of high molecular weight (HMW) adiponectin and AMP-activated protein kinase (AMPK) in db/db mice. Methods Genetically obese db/db and lean db/+ male mice were fed either ad libitum or subjected to 30% CR for 5weeks. At the end of the study period, echocardiography was carried out to assess diastolic function. Blood, heart, and epididymal fat pads were harvested for mitochondrial study, ELISA, and Western blot analyses. Results CR reversed the development of LVH, prevented diastolic dysfunction, and decreased cardiac mitochondrial H2O2 in db/db (vs. ad lib) mice. These beneficial effects on the heart were associated with increased circulating level of HMW adiponectin. Furthermore, CR increased AMPK and eNOS activation in white adipose tissue of db/db mice, but not in the heart. Conclusions These findings indicate that even short-term CR protects the heart from MHD. Whether the beneficial effects of CR on the heart could be related to the improved adipose tissue function warrants future investigation.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.10.002
      Issue No: Vol. 13 (2017)
       
  • Omeprazole and atorvastatin reduces the ability of clopidogrel to inhibit
           platelet aggregation in patients undergoing percutaneous coronary
           intervention in a tertiary health care system: A prospective drug–drug
           interaction study

    • Authors: Jinesh Bahubali Nagavi; Bannimath Gurupadayya; Preethi Gotadake Anantharaju
      Pages: 35 - 40
      Abstract: Publication date: December 2016
      Source:IJC Metabolic & Endocrine, Volume 13
      Author(s): Jinesh Bahubali Nagavi, Bannimath Gurupadayya, Preethi Gotadake Anantharaju
      Background Clopidogrel, a prodrug is found to be less effective in inhibiting the platelet aggregation when administered along with PPI's in patients undergoing cardiac stent, ST segment elevated Myocardial infarction (STEMI) followed by percutaneous coronary intervention (PCI). Clopidogrel binds to CYP2C19, a hepatic enzyme to get converted to its active metabolite in order to achieve desired pharmacological activity. The cytochrome P450 3A4 which is partially involved in the metabolism of clopidogrel also metabolizes statins, mainly atorvastatin to the greater extent. Methodology In the current study patients on PPI's with dual antiplatelet therapy and patients on PPI's and statins with dual antiplatelet therapy are considered to understand the potential drug–drug interactions (pDDI) among the South Asian population. Platelet aggregation was measured in 61 patients undergoing coronary artery stent implantation treated with clopidogrel and aspirin along with PPI's and statins. Results It was observed that omeprazole and atorvastatin, but not pantoprazole and rosuvastatin, inhibited the antiplatelet activity of clopidogrel. The percent platelet aggregation was 72±6 (p=0.001) and 43±23 (p=0.027) in the presence of clopidogrel with omeprazole and pantoprazole respectively. Aggregation was found to be 91±4 (p=0.001) and 12±23 (p=0.031) in the presence of clopidogrel with atorvastatin and rosuvastatin respectively. Conclusion A prominent drug–drug interaction was observed with patients on dual antiplatelet therapy along with omeprazole and atorvastatin.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.09.004
      Issue No: Vol. 13 (2017)
       
  • Worsening of myocardial performance index in beta-thalassemia patients
           despite permanently normal iron load at MRI: A simple and cheap index
           reflecting cardiovascular involvement'

    • Authors: Umberto Barbero; Filomena Longo; Paola Destefanis; Carmen Maria Gaglioti; Roberto Pozzi; Antonio Piga
      Pages: 41 - 44
      Abstract: Publication date: December 2016
      Source:IJC Metabolic & Endocrine, Volume 13
      Author(s): Umberto Barbero, Filomena Longo, Paola Destefanis, Carmen Maria Gaglioti, Roberto Pozzi, Antonio Piga
      Background Iron Overload Cardiomyopathy (IOC) due to repeated transfusions still represents the main cause of death in Thalassemia major (TM) patients. Because iron overload remains asymptomatic for long time, it is important to stratify the patients based on the risk of developing IOC before the appearance of clinical signs of heart failure. The magnetic resonance imaging (MRI) T2* may be useful but it is expensive and its MRI software has limited availability; conventional echocardiographic parameters, although easy availability, remain normal until advanced stages of IOC. Tissue Doppler Imaging (TDI) opened a new way to explore systolic and diastolic function directly or through derived index such as myocardial performance index (MPI) which has a prognostic value in different cardiomyopathies. Methods We enrolled 46 consecutive β-TM patients without clinical signs of heart failure and we tested them with echocardiography in 2011 and again in 2015. MPI of left and right ventricular lateral wall was calculated by TDI. All TM patients had a T2* MRI evaluation of the heart in the year before. Results Despite the absence of significant changes in morphological data at echo and at T2* evaluation, S′ waves of the lateral ventricular wall decrease while time passed, MPI worsened during the follow-up period and the derived systolic pulmonary artery systolic pressure (PAPs) increased in 2015 with respect to 2011. Conclusion TDI and MPI may reveal very early myocardial dysfunction in TM patients despite a normal T2* value. Together with PAPs they should be periodically checked in these patients.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.09.003
      Issue No: Vol. 13 (2017)
       
  • From bench to bedside: Chronic inflammation and cardiovascular risks

    • Authors: Angel López-Candales; David Harris
      Pages: 1 - 2
      Abstract: Publication date: September 2016
      Source:IJC Metabolic & Endocrine, Volume 12
      Author(s): Angel López-Candales, David Harris


      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.05.004
      Issue No: Vol. 12 (2017)
       
  • Cardiovascular risk assessment using LOX-index and Self-Rating Depression
           Scale

    • Authors: Nobutaka Inoue; Kazue Fukuyama; Sonoko Hirayama; Takayuki Yoshioka; Toru Ozawa; Sachiyo Iwata; Asumi Takei
      Pages: 3 - 7
      Abstract: Publication date: September 2016
      Source:IJC Metabolic & Endocrine, Volume 12
      Author(s): Nobutaka Inoue, Kazue Fukuyama, Sonoko Hirayama, Takayuki Yoshioka, Toru Ozawa, Sachiyo Iwata, Asumi Takei
      Objective LOX-Index is a novel biomarker for cardiovascular disease (CVD) and is calculated by multiplying LOX-1 ligands containing apolipoprotein B (LAB) and soluble LOX-1 (sLOX-1). The Framingham risk score (FRS) is a common clinical tool for risk assessment of coronary artery disease. Mental stress can also be an important risk factor for CVD. The purpose of this study was to examine the relationship between LOX-Index and FRS or mental stress. Methods LOX-Index was measured in 453 subjects including 150 consecutive outpatients with lifestyle-related diseases such as diabetes, hyperlipidemia, and hypertension and 303 healthy volunteers. Mental stress was evaluated by the Self-Rating Depression Scale (SDS). Results LOX-Index was significantly related with the 10-years risk of FRS. Multiple regression analysis demonstrated that LAB was closely associated with the smoking status, low-density lipoprotein (LDL), and high-density lipoprotein (HDL). There were no significant associations between LOX-Index and the SDS scores; however, by simultaneously using LOX-Index and SDS, the subjects could be classified in terms of oxidative stress and mental stress. Conclusions LOX-Index appears to be a comprehensive marker that could evaluate the status of multiple CVD risk factors. The classification with LOX-Index and SDS could contribute to the risk assessment for CVD.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.05.002
      Issue No: Vol. 12 (2017)
       
  • Soluble urokinase plasminogen activator receptor (suPAR): Its relation to
           neurological outcome in patients with survived cardiac arrest

    • Authors: Obaida R. Rana; Jörg W. Schröder; Alexander Koch; Frank Tacke; Ralf Koos; Robert H.G. Schwinger; Malte Kelm; Samir M. Said; Erol Saygili
      Pages: 8 - 13
      Abstract: Publication date: September 2016
      Source:IJC Metabolic & Endocrine, Volume 12
      Author(s): Obaida R. Rana, Jörg W. Schröder, Alexander Koch, Frank Tacke, Ralf Koos, Robert H.G. Schwinger, Malte Kelm, Samir M. Said, Erol Saygili
      Background High serum levels of the inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) have been associated with poor neurological outcome in patients after cardiac arrest (CA), but with inadequate and contradictive prediction values. The purpose of this study was to provide further evidence on the prognostic value of suPAR for the prediction of poor neurological outcome after initially survived CA. Methods A total of 177 patients were prospectively enrolled in this cohort study. 85 patients with survived CA were included and the neurological outcome was assessed after 6months. 71 patients with ST-segmental elevation myocardial infarction (STEMI) and 21 healthy control patients served as comparative groups. Results The serum suPAR levels on admission and the subsequent serum course were significantly higher in patients with CA as compared to STEMI and control patients. Furthermore, patients with poor neurological outcome showed significantly higher serum suPAR levels as compared to patients with good neurological outcome. By the use of ROC-curves and setting the specificities to 100%, inadequate sensitivities and cut-off values were calculated (day 2: sensitivity 21.1%, cut-off 10.2ng/dl, AUC 0.716). By setting the specificities to at least 80% the best prediction values could be calculated for day 2 with a sensitivity of 57.9% and a cut-off value of 5.3ng/dl. Conclusions SuPAR serum levels in patients with poor neurological outcome were significantly higher as compared to patients with good neurological outcome. However, the prognostic value was low and inadequate because of a substantial overlap of serum suPAR levels between the outcome groups.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.05.008
      Issue No: Vol. 12 (2017)
       
  • The relationship between skeletal muscle and ventilatory response to
           exercise in myocardial infarction

    • Authors: Hideki Hayashi; Kohji Iwai; Ryo Tobita; Tetsuya Matsumoto; Minoru Horie
      Pages: 14 - 18
      Abstract: Publication date: September 2016
      Source:IJC Metabolic & Endocrine, Volume 12
      Author(s): Hideki Hayashi, Kohji Iwai, Ryo Tobita, Tetsuya Matsumoto, Minoru Horie
      Background Skeletal muscle is important to determine physical activity and exercise capacity in cardiovascular disease. This study aims to investigate the relationship between skeletal muscle volume measured by bioelectrical impedance analysis and ventilation indices assessed by cardiopulmonary exercise test in patients with myocardial infarction. Methods A total of 60 patients (57 men; 59±9years) who underwent percutaneous coronary intervention for ST-elevation myocardial infarction were enrolled into this study. All patients performed cardiac rehabilitation and then achieved physical activity of daily life. No patient was complicated by diabetes mellitus. In symptom-limited cardiopulmonary exercise test, minute ventilation ( V ̇ E), oxygen consumption ( V ̇ O2), and carbon dioxide production ( V ̇ CO2) were continuously obtained. A volume of skeletal muscle measured by bioelectrical impedance analysis was normalized for height (skeletal muscle index). Results The skeletal muscle index showed a significant inverse correlation with peak V ̇ E/ V ̇ O2 (p=0.02, r=−0.39) and peak V ̇ E/ V ̇ CO2 (p=0.02, r=−0.30). In addition, the skeletal muscle index inversely correlated with V ̇ E/ V ̇ CO2 slope (p=0.02, r=−0.30). On the other hand, the skeletal muscle index did not significantly correlate with peak V ̇ O2 (p=0.56, r=0.08) and peak V ̇ CO2 (p=0.99, r=0.001). Besides, the skeletal muscle index did not significantly correlate with Δ V ̇ O2/Δwork rate slope (p=0.60, r=0.07). Conclusions The increase in skeletal muscle index was associated with the amelioration of ventilatory efficacy to exercise at the peak level. Furthermore, the increase in skeletal muscle index may account for favorable prognosis. These findings could strengthen the role of skeletal muscle in exercise capacity of patients with myocardial infarction.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.05.007
      Issue No: Vol. 12 (2017)
       
  • Aging impairs ischemia-induced neovascularization by attenuating the
           mobilization of bone marrow-derived angiogenic cells

    • Authors: Yuen Ting Lam; Laura Lecce; Zoe Clayton; Philippa J.L. Simpson; Richard H. Karas; Martin K.C. Ng
      Pages: 19 - 29
      Abstract: Publication date: September 2016
      Source:IJC Metabolic & Endocrine, Volume 12
      Author(s): Yuen Ting Lam, Laura Lecce, Zoe Clayton, Philippa J.L. Simpson, Richard H. Karas, Martin K.C. Ng
      Background Aging is associated with impaired ischemia-induced neovascularization. However, the effects of aging on bone marrow-derived angiogenic cell (BMDAC)-mediated vasculogenesis and on angiogenesis at the ischemic sites remain incompletely understood. Methods and results Two- and 24-month old male C57Bl/6J mice were subjected to hindlimb ischemia. The levels of Sca1+/CXCR4+ BMDACs were determined post-ischemia by flow cytometry. In young mice, ischemia increased Sca1+/CXCR4+ BMDAC levels in the bone marrow and spleen at day 3 (p<0.001) and in the circulating blood at day 7 (p<0.01) post-ischemia. However, ischemia-induced elevation of progenitor cells was attenuated in the bone marrow, spleen and blood of old mice despite a preserved HIF-1α-mediated angiogenic response in the ischemic tissues. Irradiated young recipient mice engrafted with old bone marrow displayed reduced levels of Sca1+/CXCR4+ BMDACs in the bone marrow and circulating blood post-ischemia compared to recipients with young bone marrow. Ex vivo cultured BMDACs from old mice exhibited reduced SDF-1-stimulated migration (p<0.01) and a decrease in JAK-2 and AKT activation. However, the intrinsic angiogenic function of BMDACs, including VEGF secretion and promotion of endothelial cell tubule formation, was preserved with aging. Furthermore, facilitated mobilization of old bone marrow-derived mononuclear cells to the ischemic hindlimb by intramuscular injection enhanced ischemia-induced neovascularization in old mice in vivo (p<0.001). Conclusions The age-related impairment in ischemia-induced neovascularization is largely attributable to a marked attenuation of BMDAC mobilization with a preservation of intrinsic angiogenic function with age.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.05.005
      Issue No: Vol. 12 (2017)
       
  • Diabetes, hypertension, overweight and hyperlipidemia and 7-day
           case-fatality in first myocardial infarction

    • Authors: H.K. Quintana; I. Janszky; B. Gigante; H. Druid; A. Ahlbom; J. Hallqvist; U. de Faire; K. Leander
      Pages: 30 - 35
      Abstract: Publication date: September 2016
      Source:IJC Metabolic & Endocrine, Volume 12
      Author(s): H.K. Quintana, I. Janszky, B. Gigante, H. Druid, A. Ahlbom, J. Hallqvist, U. de Faire, K. Leander
      Background Out-of-hospital deaths due to a first myocardial infarction (MI) are frequent and a big challenge for prevention. Increased knowledge about factors influencing MI fatality is needed. Metabolic risk factors have been studied in relation to MI fatality in-hospital but studies considering also out-of-hospital deaths are few. Aim To assess how diabetes and other metabolic risk factors associate with death within 7days after first time MI among subjects aged between 45 and 70 identified in Stockholm County 1992–1994. Methods Data were collected using questionnaires (close relatives of fatal cases were asked to fill the questionnaire), physical examinations, national registers and autopsy reports. Risk ratios (RR) of 7-day MI fatality with 95% confidence intervals (CI) associated with the risk factors under study were calculated using binomial regression with log link. Results Out of 1905 first time MI cases included, 524 died within 7days. After adjustments for age, sex, current smoking, education and general comorbidity, diabetes, but not hypertension and hyperlipidemia, was associated with MI fatality (RR 1.68, 95% CI 1.20–2.28). Overweight, as compared to normal BMI, was inversely associated with MI fatality (multiple adjusted RR 0.68, 95% CI 0.49–0.94); obesity results pointed in the same direction (multiple adjusted RR 0.79, 0.52–1.16). Conclusions In this population-based inception cohort study, diabetes but not hypertension and hyperlipidemia were associated with MI fatality. This further emphasizes the importance of diabetes as a cardiovascular risk factor and the need for close surveillance of diabetic patients. Overweight was however associated with decreased MI fatality.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.05.009
      Issue No: Vol. 12 (2017)
       
  • Takotsubo syndrome – A close connection to the brain: A prospective
           study investigating neuropsychiatric traits

    • Authors: Kristina N. Mayer; Jelena-Rima Ghadri; Milosz Jaguszewski; Frank Scherff; Ardan M. Saguner; Elycia Kazemian; Christian R. Baumann; Josef Jenewein; Manos Tsakiris; Thomas F. Lüscher; Peter Brugger; Christian Templin
      Pages: 36 - 41
      Abstract: Publication date: September 2016
      Source:IJC Metabolic & Endocrine, Volume 12
      Author(s): Kristina N. Mayer, Jelena-Rima Ghadri, Milosz Jaguszewski, Frank Scherff, Ardan M. Saguner, Elycia Kazemian, Christian R. Baumann, Josef Jenewein, Manos Tsakiris, Thomas F. Lüscher, Peter Brugger, Christian Templin
      Background Takotsubo syndrome (TTS) is frequently triggered by a stressful event. Overactivation of the sympathetic nervous system has been hypothesized as the underlying mechanism. In a prospective, cross-sectional, single center study we aimed to investigate neuropsychiatric traits in patients with TTS. Methods Twenty-six patients with TTS with a median latency of 17.5months from their index event underwent detailed medical examination, neuropsychologic examination, and Holter-ECG and were screened for psychiatric comorbidities, chronic stress and personality traits with questionnaires. Results 38.5% (10/26) of patients suffered from a neurological disease, and 50.0% (13/26) from at least one mental disorder. In 23.1% (6/26) the hospital anxiety scale (HADS–A) was suspicious for an anxiety disorder. There was a high prevalence of left-handedness (19.2%; 5/26). Despite good performance in cognitive testing, 11 patients had an abnormal score in the fatigue severity scale. Recovery of cardiac function was documented, although symptoms in 69.2% of patients persisted. An increase in the root mean square of the successive differences (RMSSD) (p=0.01) was noted on the Holter-ECG. Conclusion The study highlights a high prevalence of psychiatric and neurologic comorbidities in patients with TTS, which so far have been under-diagnosed. Future studies will have to show whether these patients might benefit from a combined psychocardiologic rehabilitation.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.06.001
      Issue No: Vol. 12 (2017)
       
  • Is vitamin E supplementation effective in reducing mortality related to
           cardiovascular events in people with type 2 diabetes mellitus' A
           systematic review

    • Authors: Nirav Patel; Payal Amin; Abishek Shenoy
      Pages: 42 - 45
      Abstract: Publication date: September 2016
      Source:IJC Metabolic & Endocrine, Volume 12
      Author(s): Nirav Patel, Payal Amin, Abishek Shenoy
      Objective To determine the effect of vitamin E in reducing cardiovascular mortality in diabetic patients. Data source Review of several English language primary studies published from 2004 to 2015. Outcome measured The primary outcomes measure by all studies included 30-day mortality due to congestive heart failure, myocardial infarction, stroke, and HDL function as it relates to cardiovascular outcomes. The secondary outcomes included hospitalization for CHF and coronary revascularization. Results Five Randomized, double-blind, placebo-controlled trials and 11 studies were used for this review. The study published by Jaxa-Chamiec et al. showed that vitamin E is beneficial along with vitamin C but is not effective when used alone. The study facilitated by Marchioli et al., showed that vitamin E supplementation is associated with a statistically non-significant (p=0.18) increased risk of developing CHF. Finally, a study by Milman et al. showed that vitamin E supplementation is beneficial compared with a placebo group. This was a recurring theme and common finding among the studies explored within the context of this review. Conclusions Although, two studies showed no benefit from vitamin E supplementation, the remaining studies demonstrated that vitamin E supplementation provided cardiovascular benefits in a specific diabetic subpopulation. The study population that derived a favorable outcome from vitamin E supplementation consisted of diabetic patients with the Hp 2–2 genotype. Hence, further studies should be conducted in diabetic populations with the Hp 2–2 genotype for identifying the definitive effects of vitamin E.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.06.003
      Issue No: Vol. 12 (2017)
       
  • Myocardial fibrosis pathology in Anderson–Fabry disease: Evaluation of
           autopsy cases in the long- and short-term enzyme replacement therapy, and
           non-therapy case

    • Authors: Teruaki Nagano; Shin-ichi Nakatsuka; Shigeki Fujita; Takashi Kanda; Masaaki Uematsu; Yoshihiko Ikeda; Hatsue Ishibashi-Ueda; Chikao Yutani
      Pages: 46 - 51
      Abstract: Publication date: September 2016
      Source:IJC Metabolic & Endocrine, Volume 12
      Author(s): Teruaki Nagano, Shin-ichi Nakatsuka, Shigeki Fujita, Takashi Kanda, Masaaki Uematsu, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Chikao Yutani
      Aims Enzyme replacement therapy (ERT) has been shown to be effective in the treatment of Anderson–Fabry disease (AFD). However, there have thus far been few reports on the histological findings of the heart in cases treated with ERT for more than 10years. We had an opportunity to examine the heart of an AFD patient that had received ERT for more than 10years, as well as those of two other patients, by autopsy, and compare the pathological findings. Methods and results Three AFD patients who had received ERT for different durations underwent autopsy. Marked left ventricular hypertrophy was observed in all three cases. The myocardial fibrosis of the patient that had been administered ERT for more than 10years was much slighter when compared with the remaining two cases. We further observed significant differences in globotriaosylceramide (Gb3) deposition and mitochondria in the cytoplasm of myocytes by electron microscopy. Conclusion ERT may not reduce left ventricular hypertrophy in AFD, but does prevent myocardial fibrosis when initiated before progression of fibrotic change.

      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.06.002
      Issue No: Vol. 12 (2017)
       
  • Increased body mass index is associated with ST elevation myocardial
           infarction occurrence under conditions of high environmental temperature

    • Authors: Hiroki Usuku; Eiichiro Yamamoto; Kazumasa Kurogi; Yasuhiro Izumiya; Kenichi Tsujita; Megumi Yamamuro; Sunao Kojima; Hirofumi Soejima; Koichi Kaikita; Nobuyasu Yamamoto; Seiji Hokimoto; Katsuo Noda; Hiroshige Yamabe; Shuichi Oshima; Hisao Ogawa
      Pages: 52 - 54
      Abstract: Publication date: September 2016
      Source:IJC Metabolic & Endocrine, Volume 12
      Author(s): Hiroki Usuku, Eiichiro Yamamoto, Kazumasa Kurogi, Yasuhiro Izumiya, Kenichi Tsujita, Megumi Yamamuro, Sunao Kojima, Hirofumi Soejima, Koichi Kaikita, Nobuyasu Yamamoto, Seiji Hokimoto, Katsuo Noda, Hiroshige Yamabe, Shuichi Oshima, Hisao Ogawa


      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.07.001
      Issue No: Vol. 12 (2017)
       
  • Posttraumatic stress disorder symptoms and hypercoagulability during
           emergency department evaluation for acute coronary syndrome

    • Authors: Vy Thuy Ho; Daichi Shimbo; Joan Duer-Hefele; William Whang; Melinda Chang; Donald Edmondson
      Pages: 1 - 2
      Abstract: Publication date: June 2016
      Source:IJC Metabolic & Endocrine, Volume 11
      Author(s): Vy Thuy Ho, Daichi Shimbo, Joan Duer-Hefele, William Whang, Melinda Chang, Donald Edmondson


      PubDate: 2017-07-23T16:18:06Z
      DOI: 10.1016/j.ijcme.2016.03.002
      Issue No: Vol. 11 (2017)
       
 
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