Subjects -> MEDICAL SCIENCES (Total: 8359 journals)
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CARDIOVASCULAR DISEASES (329 journals)                  1 2 | Last

Showing 1 - 200 of 329 Journals sorted alphabetically
Acta Angiologica     Open Access   (Followers: 5)
Acta Cardiologica     Hybrid Journal   (Followers: 2)
Acute Cardiac Care     Hybrid Journal   (Followers: 7)
Adipositas - Ursachen, Folgeerkrankungen, Therapie     Hybrid Journal  
AJP Heart and Circulatory Physiology     Hybrid Journal   (Followers: 12)
Aktuelle Kardiologie     Hybrid Journal   (Followers: 1)
American Heart Journal     Hybrid Journal   (Followers: 58)
American Journal of Cardiology     Hybrid Journal   (Followers: 67)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 17)
American Journal of Hypertension     Hybrid Journal   (Followers: 28)
Anales de Cirugia Vascular     Full-text available via subscription   (Followers: 1)
Anatolian Journal of Cardiology     Open Access   (Followers: 6)
Angiología     Full-text available via subscription  
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1)
Angiology     Hybrid Journal   (Followers: 3)
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (Followers: 1)
Annals of Noninvasive Electrocardiology     Hybrid Journal   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 12)
AORTA     Open Access  
Archives of Cardiovascular Diseases     Full-text available via subscription   (Followers: 5)
Archives of Cardiovascular Diseases Supplements     Full-text available via subscription   (Followers: 3)
Archives of Cardiovascular Imaging     Open Access   (Followers: 2)
Archivos de cardiología de México     Open Access   (Followers: 1)
Argentine Journal of Cardiology (English edition)     Open Access   (Followers: 2)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 1)
Arteriosclerosis, Thrombosis and Vascular Biology     Full-text available via subscription   (Followers: 32)
Artery Research     Hybrid Journal   (Followers: 4)
ARYA Atherosclerosis     Open Access  
ASAIO Journal     Hybrid Journal   (Followers: 3)
ASEAN Heart Journal     Open Access   (Followers: 2)
Asian Cardiovascular and Thoracic Annals     Hybrid Journal   (Followers: 2)
Aswan Heart Centre Science & Practice Services     Open Access   (Followers: 1)
Atherosclerosis : X     Open Access  
Bangladesh Heart Journal     Open Access   (Followers: 3)
Basic Research in Cardiology     Hybrid Journal   (Followers: 10)
BMC Cardiovascular Disorders     Open Access   (Followers: 22)
Brain Circulation     Open Access   (Followers: 1)
British Journal of Cardiology     Full-text available via subscription   (Followers: 16)
Canadian Journal of Cardiology     Hybrid Journal   (Followers: 18)
Cardiac Cath Lab Director     Full-text available via subscription  
Cardiac Electrophysiology Review     Hybrid Journal   (Followers: 2)
Cardiocore     Full-text available via subscription   (Followers: 1)
Cardiogenetics     Open Access   (Followers: 3)
Cardiology     Full-text available via subscription   (Followers: 20)
Cardiology and Angiology: An International Journal     Open Access   (Followers: 1)
Cardiology and Therapy     Open Access   (Followers: 12)
Cardiology Clinics     Full-text available via subscription   (Followers: 14)
Cardiology in Review     Hybrid Journal   (Followers: 8)
Cardiology in the Young     Hybrid Journal   (Followers: 34)
Cardiology Journal     Open Access   (Followers: 6)
Cardiology Plus     Open Access   (Followers: 1)
Cardiology Research     Open Access   (Followers: 15)
Cardiology Research and Practice     Open Access   (Followers: 10)
Cardiopulmonary Physical Therapy Journal     Hybrid Journal   (Followers: 7)
Cardiorenal Medicine     Full-text available via subscription   (Followers: 1)
Cardiothoracic Surgeon     Open Access   (Followers: 1)
CardioVasc     Full-text available via subscription   (Followers: 1)
Cardiovascular & Haematological Disorders - Drug Targets     Hybrid Journal   (Followers: 1)
Cardiovascular & Hematological Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 2)
CardioVascular and Interventional Radiology     Hybrid Journal   (Followers: 15)
Cardiovascular and Thoracic Open     Open Access  
Cardiovascular Diabetology     Open Access   (Followers: 10)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 14)
Cardiovascular Endocrinology & Metabolism     Hybrid Journal   (Followers: 1)
Cardiovascular Engineering     Hybrid Journal   (Followers: 1)
Cardiovascular Engineering and Technology     Hybrid Journal   (Followers: 1)
Cardiovascular Intervention and Therapeutics     Hybrid Journal   (Followers: 5)
Cardiovascular Journal     Open Access   (Followers: 6)
Cardiovascular Journal of Africa     Full-text available via subscription   (Followers: 5)
Cardiovascular Journal of South Africa     Full-text available via subscription   (Followers: 1)
Cardiovascular Medicine in General Practice     Full-text available via subscription   (Followers: 7)
Cardiovascular Pathology     Hybrid Journal   (Followers: 4)
Cardiovascular Regenerative Medicine     Open Access  
Cardiovascular Research     Hybrid Journal   (Followers: 15)
Cardiovascular Revascularization Medicine     Hybrid Journal   (Followers: 1)
Cardiovascular System     Open Access  
Cardiovascular Therapeutics     Open Access   (Followers: 1)
Cardiovascular Toxicology     Hybrid Journal   (Followers: 6)
Cardiovascular Ultrasound     Open Access   (Followers: 5)
Case Reports in Cardiology     Open Access   (Followers: 7)
Catheterization and Cardiovascular Interventions     Hybrid Journal   (Followers: 3)
Cerebrovascular Diseases     Full-text available via subscription   (Followers: 3)
Cerebrovascular Diseases Extra     Open Access  
Chest     Full-text available via subscription   (Followers: 100)
Choroby Serca i Naczyń     Open Access   (Followers: 1)
Circulation     Hybrid Journal   (Followers: 247)
Circulation : Cardiovascular Imaging     Hybrid Journal   (Followers: 15)
Circulation : Cardiovascular Interventions     Hybrid Journal   (Followers: 17)
Circulation : Cardiovascular Quality and Outcomes     Hybrid Journal   (Followers: 11)
Circulation : Genomic and Precision Medicine     Hybrid Journal   (Followers: 15)
Circulation : Heart Failure     Hybrid Journal   (Followers: 26)
Circulation Research     Hybrid Journal   (Followers: 36)
Cirugía Cardiovascular     Open Access  
Clínica e Investigación en Arteriosclerosis     Full-text available via subscription  
Clínica e Investigación en arteriosclerosis (English Edition)     Hybrid Journal  
Clinical and Experimental Hypertension     Hybrid Journal   (Followers: 3)
Clinical Cardiology     Hybrid Journal   (Followers: 11)
Clinical Hypertension     Open Access   (Followers: 5)
Clinical Medicine Insights : Cardiology     Open Access   (Followers: 6)
Clinical Research in Cardiology     Hybrid Journal   (Followers: 6)
Clinical Research in Cardiology Supplements     Hybrid Journal  
Clinical Trials and Regulatory Science in Cardiology     Open Access   (Followers: 4)
Congenital Heart Disease     Hybrid Journal   (Followers: 6)
Congestive Heart Failure     Hybrid Journal   (Followers: 4)
Cor et Vasa     Full-text available via subscription   (Followers: 1)
Coronary Artery Disease     Hybrid Journal   (Followers: 2)
CorSalud     Open Access  
Critical Pathways in Cardiology     Hybrid Journal   (Followers: 4)
Current Cardiology Reports     Hybrid Journal   (Followers: 7)
Current Cardiology Reviews     Hybrid Journal   (Followers: 4)
Current Cardiovascular Imaging Reports     Hybrid Journal   (Followers: 1)
Current Cardiovascular Risk Reports     Hybrid Journal  
Current Heart Failure Reports     Hybrid Journal   (Followers: 5)
Current Hypertension Reports     Hybrid Journal   (Followers: 6)
Current Hypertension Reviews     Hybrid Journal   (Followers: 6)
Current Opinion in Cardiology     Hybrid Journal   (Followers: 14)
Current Problems in Cardiology     Hybrid Journal   (Followers: 3)
Current Research : Cardiology     Full-text available via subscription   (Followers: 1)
Current Treatment Options in Cardiovascular Medicine     Hybrid Journal   (Followers: 1)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 5)
CVIR Endovascular     Open Access   (Followers: 1)
Der Kardiologe     Hybrid Journal   (Followers: 2)
Echo Research and Practice     Open Access   (Followers: 2)
Echocardiography     Hybrid Journal   (Followers: 4)
Egyptian Heart Journal     Open Access   (Followers: 2)
Egyptian Journal of Cardiothoracic Anesthesia     Open Access  
ESC Heart Failure     Open Access   (Followers: 4)
European Heart Journal     Hybrid Journal   (Followers: 67)
European Heart Journal - Cardiovascular Imaging     Hybrid Journal   (Followers: 10)
European Heart Journal - Cardiovascular Pharmacotherapy     Full-text available via subscription   (Followers: 3)
European Heart Journal - Quality of Care and Clinical Outcomes     Hybrid Journal  
European Heart Journal : Acute Cardiovascular Care     Hybrid Journal   (Followers: 1)
European Heart Journal : Case Reports     Open Access   (Followers: 1)
European Heart Journal Supplements     Hybrid Journal   (Followers: 8)
European Journal of Cardio-Thoracic Surgery     Hybrid Journal   (Followers: 9)
European Journal of Cardio-Thoracic Surgery Supplements     Full-text available via subscription   (Followers: 2)
European Journal of Cardiovascular Nursing     Hybrid Journal   (Followers: 5)
European Journal of Heart Failure     Hybrid Journal   (Followers: 14)
European Journal of Preventive Cardiology.     Hybrid Journal   (Followers: 6)
European Stroke Organisation     Hybrid Journal   (Followers: 3)
Experimental & Translational Stroke Medicine     Open Access   (Followers: 8)
Expert Review of Cardiovascular Therapy     Full-text available via subscription   (Followers: 3)
Folia Cardiologica     Open Access  
Forum Zaburzeń Metabolicznych     Hybrid Journal  
Frontiers in Cardiovascular Medicine     Open Access   (Followers: 1)
Future Cardiology     Hybrid Journal   (Followers: 6)
General Thoracic and Cardiovascular Surgery     Hybrid Journal   (Followers: 3)
Global Cardiology Science and Practice     Open Access   (Followers: 5)
Global Heart     Hybrid Journal   (Followers: 3)
Heart     Hybrid Journal   (Followers: 48)
Heart and Mind     Open Access  
Heart and Vessels     Hybrid Journal  
Heart Failure Clinics     Full-text available via subscription   (Followers: 2)
Heart Failure Reviews     Hybrid Journal   (Followers: 3)
Heart India     Open Access   (Followers: 2)
Heart International     Full-text available via subscription  
Heart Rhythm     Hybrid Journal   (Followers: 11)
Heart Views     Open Access   (Followers: 2)
HeartRhythm Case Reports     Open Access  
Hellenic Journal of Cardiology     Open Access   (Followers: 1)
Herz     Hybrid Journal   (Followers: 3)
High Blood Pressure & Cardiovascular Prevention     Full-text available via subscription   (Followers: 2)
Hypertension     Full-text available via subscription   (Followers: 23)
Hypertension in Pregnancy     Hybrid Journal   (Followers: 9)
Hypertension Research     Hybrid Journal   (Followers: 5)
Ibrahim Cardiac Medical Journal     Open Access  
IJC Heart & Vessels     Open Access   (Followers: 1)
IJC Heart & Vasculature     Open Access   (Followers: 1)
IJC Metabolic & Endocrine     Open Access   (Followers: 1)
Indian Heart Journal     Open Access   (Followers: 5)
Indian Journal of Cardiovascular Disease in Women WINCARS     Open Access  
Indian Journal of Thoracic and Cardiovascular Surgery     Hybrid Journal  
Indian Pacing and Electrophysiology Journal     Open Access   (Followers: 1)
Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery     Hybrid Journal   (Followers: 1)
Insuficiencia Cardíaca     Open Access  
Interactive CardioVascular and Thoracic Surgery     Hybrid Journal   (Followers: 7)
International Cardiovascular Forum Journal     Open Access  
International Journal of Angiology     Hybrid Journal   (Followers: 2)
International Journal of Cardiology     Hybrid Journal   (Followers: 18)
International Journal of Cardiovascular and Cerebrovascular Disease     Open Access   (Followers: 2)
International Journal of Cardiovascular Imaging     Hybrid Journal   (Followers: 2)
International Journal of Cardiovascular Research     Hybrid Journal   (Followers: 6)
International Journal of Heart Rhythm     Open Access  
International Journal of Hypertension     Open Access   (Followers: 8)
International Journal of Hyperthermia     Open Access  
International Journal of Stroke     Hybrid Journal   (Followers: 30)
International Journal of the Cardiovascular Academy     Open Access  
Interventional Cardiology Clinics     Full-text available via subscription   (Followers: 2)
Interventional Cardiology Review     Full-text available via subscription  
JACC : Basic to Translational Science     Open Access   (Followers: 5)
JACC : Cardiovascular Imaging     Hybrid Journal   (Followers: 18)
JACC : Cardiovascular Interventions     Hybrid Journal   (Followers: 17)
JACC : Heart Failure     Full-text available via subscription   (Followers: 14)
JAMA Cardiology     Hybrid Journal   (Followers: 28)
JMIR Cardio     Open Access  
Jornal Vascular Brasileiro     Open Access  
Journal of Clinical & Experimental Cardiology     Open Access   (Followers: 5)
Journal of Arrhythmia     Open Access  
Journal of Cardiac Critical Care TSS     Open Access   (Followers: 1)
Journal of Cardiac Failure     Hybrid Journal   (Followers: 1)

        1 2 | Last

Similar Journals
Journal Cover
Cardiovascular Pathology
Journal Prestige (SJR): 0.885
Citation Impact (citeScore): 2
Number of Followers: 4  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1054-8807 - ISSN (Online) 1879-1336
Published by Elsevier Homepage  [3147 journals]
  • Mitochondria in aneurysms and dissections of the human ascending aorta
    • Abstract: Publication date: Available online 25 January 2020Source: Cardiovascular PathologyAuthor(s): Paulo Sampaio Gutierrez, Mário Luiz Marques Piubelli, Kalil Georgetto Naal, Ricardo Ribeiro Dias, Luciano Figueiredo BorgesFactors causing the weakness that underlies thoracic aorta aneurysms and dissections are not well known. Based on the findings of apoptosis and ischemic-like necrosis, we hypothesized a possible role for mitochondrial disturbances in the pathogenesis of these diseases. To evaluated if mitochondria at the aortic medial layer are damaged, samples of ascending aortas with aneurysms (n=6), acute dissections (n=5), hypertensive (n=9) and normotensive controls (n=7) were analyzed by transmission electron microscopy. Number of mitochondria, areas of cytoplasm, and areas of mitochondria were measured, and area percentage of the cytoplasm corresponding to mitochondria, their number by unit of area, and their mean area were calculated in randomly taken photographs. Data were compared using one-way ANOVA or Kruskal-Wallis tests. Significant differences (p≤0.05) were found in the number of mitochondria and their mean area, showing opposite results: the number increased and mean area decreased from normotensive controls to hypertensive controls to acute dissections to aneurysms, although post-hoc tests showed that only the differences between the aneurysms and either both controls (number of mitochondria/mm2- 10.37 in normotensive controls, 15.61 in hypertensive controls, and 43.67 in aneurysms) or normotensive controls only (mean area- 2800.15 in normotensive controls vs 894.91μm2 in aneurysms) were significant. In conclusion, there are more, smaller mitochondria in ascending aorta aneurysms. This pattern possibly corresponds to dysfunctional mitochondria, indicating that alterations in the dynamics of these organelles may play a role in the pathogenesis of thoracic aorta aneurysms and dissections.Graphical abstractImage 1
  • Giant cell arteritis in a patient with aortic dissection: A case report
    • Abstract: Publication date: Available online 23 January 2020Source: Cardiovascular PathologyAuthor(s): Hiyo Obikane, Toshiki Fujiyoshi, Satoshi Takahashi, Hitoshi Ogino, Jun Matsubayashi, Toshitaka Nagao, Hatsue Ishibashi-UedaAbstractAortic lesions, such as an aortic aneurysm, are known as a late complication that usually occurs several years after the onset of giant cell arteritis (GCA). Here, we report a rare case of large-vessel GCA in a patient with aortic dissection. A 71-year-old man presented with acute back pain and was diagnosed with aortic dissection, Stanford type A, and he underwent elective ascending aortic replacement. Further studies showed that the resected ascending aorta had aortic dissection and multinucleated giant cell granulomas; the granulomas were located in the media near the intima with partial destruction of the internal elastic lamina; there was no stenosis of the feeding blood vessel or fibrosis of the adventitia as observed in Takayasu arteritis (TKA); other types of vasculitis were considered unlikely based on the symptoms and laboratory data. The patient was further diagnosed with GCA, which was classified as a large vessel vasculitis along with TKA at the Chapel Hill Consensus Conference in 2012. This is a rare case of GCA diagnosed in a patient with aortic dissection. The differences in histopathological findings between TKA and GCA are discussed.
  • Isomerism of the Atrial Appendages: Morphology and Terminology
    • Abstract: Publication date: Available online 16 January 2020Source: Cardiovascular PathologyAuthor(s): Carla Frescura, Siew Yen Ho, Gaetano ThieneAbstractBackgroundOur aim is to identify the pathognomonic anatomical markers and the best terminology to describe the cardiac malformations associated with absent or multiple spleens, that are known as asplenia or polysplenia syndromes or isomerism.Materials and methodsWe have reviewed the 65 hearts with isomerism of atrial appendages of the Anatomical Collection of Congenital Heart Disease of the Institute of Pathological Anatomy of the University of Padua consisting in 1800 specimens. All the hearts were classified according to sequential segmental classification.ResultsThe incidence of isomerism was 3,6%. All the 45 hearts with isomerism of right atrial appendages showed bilateral trilobed lungs, short bronchi and absent spleen. The atrioventricular junction was univentricular in 49% of cases with a common atrioventricular valve in 91%. Pulmonary atresia and double outlet right ventricle were present in 40% and 47% of cases respectively. Total anomalous pulmonary venous drainage and absent coronary sinus were always present. In the 20 hearts with isomerism of left atrial appendages, bilateral bilobed lungs with long bilateral bronchi and multiple spleens were always found. Biventricular atrioventricular connection was present in 65% with a common valve in 30% of the hearts. The ventriculo-arterial connection was concordant in 45% of cases and aortic atresia and pulmonary atresia were noted both in 15% of each. An anomalous symmetric pulmonary venous drainage was observed in 65% of the hearts and interruption of inferior vena cava was found in 75% of cases.ConclusionsWe believe that the appropriate terminology is based on the symmetrical morphology of the atrial appendages. The absence of the coronary sinus and the total anomalous pulmonary venous drainage are the markers of isomerism of the right atrial appendages. Symmetric pulmonary venous drainage and interruption of inferior vena cava are the markers of isomerism of left atrial appendages. In recent years, thanks to improvement of clinical diagnosis and of surgical techniques these patients have the possibility to survive to adult age.
  • Takotsubo Cardiomyopathy Presenting with Different Morphological Patterns
           in the Same Patient: A case report and review of the literature
    • Abstract: Publication date: Available online 15 January 2020Source: Cardiovascular PathologyAuthor(s): Abdulmohsin Ahmadjee, Khader Herzallah, Yehia Saleh, George S. AbelaAbstractBackgroundTakotsubo Cardiomyopathy is characterized by transient left ventricular systolic dysfunction, which often mimics a myocardial infarction and is usually triggered by emotional or physical stress. There are four variants of Takotsubo Cardiomyopathy, based on the affected left ventricular area.CaseWe report a 75-year-old female with a past medical history of diabetes mellitus, hypertension, hyperlipidemia and chronic kidney disease who presented with chest pain that started after a stressful emotional event. Her electrocardiogram showed no ischemic changes, troponin was mildly elevated and cardiac catheterization revealed non-obstructive coronary artery disease. Echocardiogram showed a decreased ejection fraction and apical akinesia with basal hyperkinesia consistent with classical Takotsubo Cardiomyopathy.Decision-makingThe patient symptomatically improved on optimal heart failure therapy and a follow up echocardiogram showed improvement in her systolic function. Over a year later, the patient was readmitted with chest pain, which also began after an emotional event. ECG showed non-specific ST-T wave changes and troponin was mildly elevated. Echocardiogram demonstrated a reduced ejection fraction and inferior akinesia with apical hyperkinesia consistent with reverse Takotsubo Cardiomyopathy. A repeat cardiac catheterization exhibited mild non-obstructive coronary artery disease unchanged from her previous. A follow up echocardiogram showed full recovery of her systolic function.ConclusionClassical and reverse Takotsubo Cardiomyopathy due to different stressors have been reported in the literature individually, but up to our knowledge, both variants of Takotsubo Cardiomyopathy occurring in the same patient has not been reported previously.
  • A Rare Case of Post-Infarction Right Ventricular Rupture
    • Abstract: Publication date: Available online 15 January 2020Source: Cardiovascular PathologyAuthor(s): Samadhi Dandeniyaarachci, Rohan RuwanpuraAbstractA 62-year-old male patient was pronounced dead on admission to the tertiary care hospital. The victim had right ventricular STEMI three years ago. The autopsy showed pericardial tamponade due to rupture of an acute myocardial infarction of the right ventricle.
  • Acute fatal myocarditis after a single dose of anti-pd-1 immunotherapy,
           autopsy findings: a case report
    • Abstract: Publication date: Available online 15 January 2020Source: Cardiovascular PathologyAuthor(s): Tanner Hardy, Ming Yin, Jesus A. Chavez, Iouri Ivanov, Wei Chen, Tibor Nadasdy, Sergey V. BrodskyAbstractNivolumab (PD-1 inhibitor) and Ipilimumab (CTLA-34 inhibitor) are both commonly used immune checkpoint inhibitor therapies for various cancers. Various adverse events are associated with these therapies including hepatitis, nephritis, dermatitis, and myocarditis. It is believed these adverse events occur in part because modified cellular receptors lead to enhanced CD4 and CD8 lymphoproliferation. These events usually occur after several months and rounds of treatment. Here we present a case of an 81-year-old male with recurrent renal cell carcinoma (RCC) who experienced myocarditis after only a single dose of combination therapy with Nivolumab and Ipilimumab. He presented with elevated troponins and a 3rd degree heart block; three days after admission he died. Histologic examination revealed a predominance of CD3 T cells (CD4> CD8) and CD68 macrophages, with occasional CD20 B cells. C4d staining was negative in the interstitial capillaries, suggesting that antibody-mediated injury of endothelial cells did not play a significant role in the pathogenesis of this myocarditis. Additional studies ruled out an infectious etiology. Immune checkpoint inhibitors are increasingly more common, and it is important clinicians are aware patients can present with myocarditis early in the course of treatment.
  • Table of Contents/Barcode PMS 200
    • Abstract: Publication date: March–April 2020Source: Cardiovascular Pathology, Volume 45Author(s):
  • Pathological Changes Secondary To Pacing Leads Within The Coronary Veins
    • Abstract: Publication date: Available online 9 January 2020Source: Cardiovascular PathologyAuthor(s): Jose Coelho-Lima, Joanne Chapman, H. Sern Lim, Desley A.H. Neil
  • Comparative Pathology of Human and Canine Myxomatous Mitral Valve
           Degeneration: 5HT and TGF-β Mechanisms
    • Abstract: Publication date: Available online 7 January 2020Source: Cardiovascular PathologyAuthor(s): Mark A. Oyama, W. Chad Elliott, Kerry A. Loughran, Alexander P. Kossar, Estibaliz Castillero, Robert J. Levy, Giovanni FerrariAbstractMyxomatous mitral valve degeneration (MMVD) is a leading cause of valve repair or replacement secondary to the production of mitral regurgitation, cardiac enlargement, systolic dysfunction, and heart failure. The pathophysiology of MMVD is complex and incompletely understood, but key features include activation and transformation of mitral valve (MV) valvular interstitial cells (VICs) into an active phenotype leading to remodeling of the extracellular matrix and compromise of the structural components of the MV leaflets. Uncovering the mechanisms behind these events offers the potential for therapies to prevent, delay, or reverse MMVD. One such mechanism involves the neurotransmitter serotonin (5HT), which has been linked to development of valvulopathy in a variety of settings, including valvulopathy induced by serotonergic drugs, 5HT-producing carcinoid tumors and development of valvulopathy in laboratory animals exposed to high levels of 5HT. Similar to humans, the domestic dog also experiences naturally-occurring MMVD, and in some breeds of dogs, the lifetime prevalence of MMVD reaches 100%. In dogs, MMVD has been associated with high serum 5HT, increased expression of 5HT-receptors, autocrine production of 5HT within the MV leaflets, and down regulation of 5HT clearance mechanisms. One pathway closely associated with 5HT involves transforming growth factor beta (TGF-β) and the two pathways share a common ability to activate MV VICs in both humans and dogs. Understanding the role of 5HT and TGF-β in MMVD gives rise to potential therapies, such as 5HT receptor (5HT-R) antagonists. The main purposes of this review are to highlight the commonalities between MMVD in humans and dogs, with specific regards to 5HT and TGF-β, and to champion the dog as a relevant and particularly valuable model of human disease that can accelerate development of novel therapies.
  • Papillary fibroelastoma on pulmonary valve – valve sparing surgery of a
           cardiac tumor in a rare location
    • Abstract: Publication date: Available online 2 January 2020Source: Cardiovascular PathologyAuthor(s): Tomas Grus, Petr Kuchynka, Tomas Palecek, Ladislav Hadravsky, Tomas Urbanec, Lukas LambertWe present images of a papillary fibroelastoma on a pulmonary valve – echocardiography, intraoperative images, macroscopic and microscopic images of the tumor in this uncommon location.Graphical abstractImage 1
  • Heart Failure In Breast Cancer Survivors: Implications Of miR126'
    • Abstract: Publication date: Available online 20 December 2019Source: Cardiovascular PathologyAuthor(s): Raffaella Mormile
  • Induction of aortic valve calcification by Celecoxib and its COX-2
           independent derivatives is glucocorticoid-dependent
    • Abstract: Publication date: Available online 19 December 2019Source: Cardiovascular PathologyAuthor(s): Kiran A. Vaidya, Matthew P. Donnelly, Terence W. Gee, Marine-Ayan Ibrahim Aibo, Stephen Byers, Jonathan T. ButcherBackgroundCelecoxib, a selective COX-2 inhibitor, was recently associated with increased incidence of aortic stenosis and found to produce a valvular calcification risk in vitro. Several COX-2 independent Celecoxib derivatives have been developed and identified as possible therapies for inflammatory diseases due to their Cadherin-11 (Cad11) inhibitory functions. Potential cardiovascular toxicities associated with these COX-2 independent Celecoxib derivatives have not yet been investigated. Furthermore, the mechanism by which Celecoxib produces valvular toxicity is not known.Methods and ResultsCelecoxib treatment produces a 2.8-fold increase in calcification in ex vivo porcine aortic valve leaflets and a more than 2-fold increase in calcification in porcine aortic valve interstitial cells (PAVICs) cultured in osteogenic media. Its COX-2 independent derivative, 2,5-dimethylcelecoxib (DMC), produces a similar 2.5-fold increase in calcification in ex vivo leaflets and a 13-fold increase in PAVICs cultured in osteogenic media. We elucidate that this off-target effect depends on the presence of either of two media components: dexamethasone, a synthetic glucocorticoid used for osteogenic induction or cortisol, a natural glucocorticoid present at basal levels in the Fetal Bovine Serum. In the absence of glucocorticoids, these inhibitors effectively reduce calcification. By adding glucocorticoids or hydrocortisone to a serum substitute lacking endogenous glucocorticoids, we show that DMC conditionally induces a 3.5-fold increase in aortic valve calcification and osteogenic expression. Treatment with the MEK inhibitor, U0126, rescues the off-target effect, suggesting that Celecoxib and DMC conditionally augment MEK/ERK activity in the presence of glucocorticoids.ConclusionHere we identify glucocorticoids as a possible source of the increased valvular calcification risk associated with Celecoxib and its COX-2 independent derivatives. In the absence of glucocorticoids, these inhibitors effectively reduce calcification. Furthermore, the off-target effects are not due to the drug’s intrinsic properties as dual COX-2 and Cad11 inhibitors. These findings inform future design and development of Celecoxib derivatives for potential clinical therapy.Graphical abstractImage 1
  • Multiple Ulcerations and Perforation in the Small Intestine After Steroid
           Treatment in Eosinophilic Granulomatosis with Polyangiitis: A Case Report
           and Literature Review
    • Abstract: Publication date: Available online 18 December 2019Source: Cardiovascular PathologyAuthor(s): Yukinobu Ito, Makoto Yoshida, Tatsuo Sugiyama, Hirotake Masuda, Mitsuo Mori, Noriyuki Kimura, Michinobu Umakoshi, Ken Miyabe, Yukitsugu Kudo-Asabe, Akiteru GotoAbstractEosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is an uncommon disease with pathological features consisting of systemic necrotizing vasculitis, eosinophilic infiltration, and granulomatous or non-granulomatous extravascular eosinophilic inflammation. EGPA preferentially affects certain organ systems, including the airways, peripheral nerves, heart, kidney, and gastrointestinal tract. Although gastrointestinal involvement, such as ulcerations, is common in EGPA, gastrointestinal perforation is relatively uncommon and is associated with a poor prognosis. Ulceration, perforation, and stenosis of the gastrointestinal tract are assumed to be the result of ischemia caused by vasculitis. The histological findings in the biopsy specimens of EGPA are generally only eosinophil infiltration, and vasculitis is not often seen. Therefore, on biopsy specimens, it is difficult to distinguish eosinophilic gastroenteritis from the gastrointestinal involvement of EGPA. In addition, in general, steroid therapy is the first-choice treatment for EGPA, but some reports have described the frequent occurrence of acute ulcer or perforation of the gastrointestinal tract in association with steroid treatment. We herein report an EGPA patient who was treated with steroid therapy and subsequently developed perforation of the small intestine.
  • Relationships between visceral/subcutaneous adipose tissue FABP4
           expression and coronary atherosclerosis in patients with metabolic
    • Abstract: Publication date: Available online 6 December 2019Source: Cardiovascular PathologyAuthor(s): Selcuk Gormez, Refik Erdim, Gokce Akan, Barıs Caynak, Cihan Duran, Demet Gunay, Volkan Sozer, Fatmahan AtalarAbstractBackgroundCytoplasmic fatty acid-binding proteins facilitate the transport of lipids to specific compartments in cells. Fatty acid-binding protein 4 (FABP4), also known as aP2 or A-FABP, plays a key role in the development of atherosclerosis, insulin resistance, obesity, and metabolic syndrome (MS). The FABP4 polymorphisms are associated with protein expression changes in vitro and metabolic and vascular alterations in vivo. The aim of this study was to investigate the association between FABP4 messenger ribonucleic acid (mRNA) expression levels in epicardial (EAT), pericardial (PAT), and subcutaneous adipose tissues (SAT) and the extent of coronary atherosclerosis in coronary artery disease (CAD) patients with MS. Furthermore, the relationship between the extent of coronary atherosclerosis and epicardial adipose tissue volume (EATV) and FABP4 gene variations was evaluated.Patients and MethodsA total of 37 patients undergoing coronary artery bypass grafting due to CAD (MS CAD group) and 23 non-MS patients undergoing heart valve surgery (control group) were included. Coronary angiography was performed for all patients and the extent of coronary atherosclerosis was assessed using the Sullivan’s scoring system. The mRNA expression levels of FABP4 gene in EAT, PAT, and SAT and FABP4 polymorphisms were analyzed using the quantitative real-time polymerase chain reaction (qRT-PCR).ResultsAn increased FABP4 expression was observed in EAT and PAT of MS CAD group compared to controls. In the MS CAD group, FABP4 mRNA expression levels in EAT was 2.8-fold higher, compared to PAT. The expression of FABP4 in EAT was positively correlated with the extent of atherosclerosis and EATV in MS CAD group (r=0.588, p=0.001, r=0.174, p=0.001, respectively). There were no correlations between PAT and SAT versus the extent of atherosclerosis and EATV. The FABP4 EAT mRNA expression levels were found to significantly increase in mutant allele carriers of rs1054135, while they significantly decreased in mutant allele carriers of rs77878271(T-87C) in MS CAD group (p
  • Recurrent pericardial effusion with pericardial amyloid deposition: a case
           report and literature review
    • Abstract: Publication date: Available online 6 December 2019Source: Cardiovascular PathologyAuthor(s): Hiroko Itagaki, Tomoko Yamamoto, Kenta Uto, Atsuko Hiroi, Hiromi Onizuka, Hiroyuki Arashi, Eiji Shibahashi, Shogo Isomura, Hideaki Oda, Taro Yamashita, Yoji NagashimaAbstractPericardial amyloidosis is a rare cause of pericardial effusion. Here, we report a case of recurrent pericardial effusion due to pericardial amyloid deposition. The patient was a man in his 40s admitted for pulmonary embolism. During hospitalization, arterial fibrillation and cardiac tamponade were observed, and an initial pericardial puncture was performed. Thereafter, pericardial puncture was repeated nine times over the next two years. Cytological examination of the pericardial effusion suggested malignant mesothelioma. Afterward, pericardial fenestration and partial resection were performed. Intraoperatively, a thickened pericardium and hemorrhagic pericardial effusion were noted. Histologically, the surface of the pericardium was covered by an eosinophilic amorphous material. Congo red and Dylon stains, electron microscopy, and immunohistochemical findings revealed localized amyloidosis composed of an immunoglobulin lambda light chain. Although the patient did not receive further treatment for 5 years postoperatively, his renal and cardiac functions remained within normal limits. Based on these findings, the patient was diagnosed with localized amyloidosis. So far, hemorrhagic pericardial effusion has been reported in few cases with systemic amyloidosis. Since localized immunoglobulin light-chain-derived (AL) amyloidosis may progress to systemic disease (although it is a very rare occurrence), long-term follow-up is necessary to detect recurrence or progression to a systemic form.
  • Clinicopathological Manifestations of Myocarditis in a Heart Failure
    • Abstract: Publication date: Available online 2 December 2019Source: Cardiovascular PathologyAuthor(s): L. Maximilian Buja, Giulia Ottaviani, Milica Ilic, Bihong Zhao, Laura C. Lelenwa, Ana Maria Segura, Yu Bai, Alice Chen, Bindu Akkanti, Rahat Hussain, Sriram Nathan, Marija Petrovic, Rajko Radovancevic, Igor D. Gregoric, Biswajit KarAbstractMyocarditis continues to present challenges in diagnosis and management. The goal of this study is to determine the occurrence and manifestations of myocarditis in a heart failure (HF) population. The analyzed patients had acute or persistent HF and were referred over a 6-year period to a quaternary HF center for advanced HF therapies including mechanical circulatory support, left ventricular assist device (LVAD) implantation, and/or heart transplantation. The histopathological diagnosis of myocarditis was made based on the presence of an inflammatory infiltrate of the myocardium, typically with associated cardiomyocyte (CMC) damage, combined as indicated with immunohistochemical and molecular biology characterization. The pathological findings were correlated with a panel of clinical parameters and clinical course of the patients. Myocarditis was identified in 36 patients, with initial diagnoses made in 10 (40%) of 25 by endomyocardial biopsy (EMB), 1 by atrial biopsy (Maze procedure), 7 (2.1%) of 331 at LVAD implantation and 18 (7.8%) of 229 in the explanted heart. There were 20 cases of lymphocytic myocarditis, 4 cases of giant cell myocarditis, 3 cases of eosinophilic myocarditis, and 9 cases of granulomatous myocarditis. EMB was performed in 25 patients and was positive in 10 (40%) of cases. Myocarditis was found in 23 explanted hearts including 18 cases de novo and 5 cases with a previously positive specimen. Of the 23 explanted hearts, 21 were non-ischemic cardiomyopathy and 2 were ischemic cardiomyopathy. Our findings show that, in patients presenting to a quaternary medical center, myocarditis can be manifest as acute HF as well as a complicating factor in chronic HF.
  • Cardiac varix: an example via a case report of a radiological
           mimicker of cardiac myxoma
    • Abstract: Publication date: Available online 26 November 2019Source: Cardiovascular PathologyAuthor(s): Simona Pichler Sekulic, Akisha Glasgow, Jay Wasman, Joseph F. Sabik, Brian Fitzsimons, Miroslav SekulicAbstractCardiac myxoma is the most frequently encountered primary neoplasm of the heart, however other tumefactive lesions can share similar radiologic features. We present briefly the case of a 69-year-old man incidentally found to have a mobile right atrial mass that based on initial radiologic findings was considered to represent a myxoma. After pathologic examination, the lesion was determined instead to be a cardiac varix: an endocardial, blood filled cystic space lined by endothelium and considered to represent a dilated vein.
  • Moyamoya disease associated with fibromuscular dysplasia of intrapulmonary
           bronchial arteries- a case report
    • Abstract: Publication date: Available online 23 November 2019Source: Cardiovascular PathologyAuthor(s): Václav Stejskal, Ivo Šteiner, Helena Hornychová, Petr Krůpa, Martin KantaAbstractA case is reported of a 40-year-old female clinically diagnosed as moyamoya disease, with associated fibromuscular dysplasia of intrapulmonary bronchial arteries incidentally revealed during autoptic examination. Moyamoya disease represents an idiopathic non-inflammatory and non-atherosclerotic arterio-occlusive process of intracranial arteries. Prolonged brain ischaemia leads to formation of tiny and fragile collaterals. Clinically, patients with moyamoya angiopathy commonly present with severe neurological symptoms caused by brain infarction or haemorrhage. Histologically, the steno-occlusive process is based on fibrocellular thickening of intima and intimal smooth muscle cell proliferation. In the literature, extracranial arterial involvement, i.e. fibromuscular dysplasia of renal or pulmonary arteries, has been described in several cases of moyamoya disease. Our aim is to show a unique case of moyamoya disease associated with fibromuscular dysplasia affecting an uncommon site.
  • MiR-29a in mesenchymal stem cells inhibits FSTL1 secretion and promotes
           cardiac myocyte apoptosis in hypoxia-reoxygenation injury
    • Abstract: Publication date: Available online 19 November 2019Source: Cardiovascular PathologyAuthor(s): Kun-Sheng Li, Wei-Peng Jiang, Qiu-Chang Li, Hao-Wen Zhang, Yang Bai, Xia Zhang, Hai-Ying LiAbstractBackgroundMesenchymal stem cells (MSCs) are under consideration for myocardial ischaemia-reperfusion (I/R) injury therapy, but their mechanism remains to be evaluated. In this paper, we aimed to study the effects of the miR-29a/FSTL1 axis in BMSCs on modulating myocyte apoptosis after hypoxia-reoxygenation (H/R) injury.MethodsAn in vitro myocardial I/R injury model of H9c2 cells was developed by H/R injury. The mRNA levels of FSTL1, Bcl-2, Bax and miR-29a and the protein levels of Bcl-2, Bax, cleaved caspase-3 and components of the JAK2/STAT3 pathway were detected by qRT-PCR and western blotting, respectively. Secretion of FSTL1 was evaluated by ELISA. Cell apoptosis was evaluated by flow cytometry. The interaction between miR-29a and FSTL1 was evaluated by dual luciferase reporter assay.ResultsMiR-29a suppressed the expression and secretion of FSTL1 in BMSCs. Overexpression of FSTL1 in BMSCs decreased apoptosis of myocytes induced by H/R. Cell apoptosis in myocytes was promoted by conditioned medium from BMSCs with ectopic miR-29a expression. Conditioned medium of miR-29a-overexpressing BMSCs inhibited the JAK2/STAT3 pathway in myocytes to promote apoptosis of myocytes.ConclusionsMiR-29a in BMSCs inhibits FSTL1 secretion and promotes myocyte apoptosis by suppressing the JAK2/STAT3 pathway in H/R injury.
  • Ultrastructural effects of diabetes in the right atrium cardiomyocytes of
           elderly Wistar rats
    • Abstract: Publication date: Available online 19 November 2019Source: Cardiovascular PathologyAuthor(s): Natalie Souza de Andrade, Kemily Loren Barros Chucata, Walkyria Villegas Magalhães, Ricardo Aparecido Baptista Nucci, Nicolas Da Costa-Santos, Igor Roberto Dias, Hunter Douglas de Souza Lima, Laura Beatriz Mesiano Maifrino, Romeu Rodrigues de SouzaAbstractThe present study aimed to evaluate the effects of diabetes on quantitative parameters of right atrial cardiomyocytes of elderly rats. Wistar rats (14-mo of age) were divided into two groups: streptozotocin-diabetic rats (DG); and control rats (CG). The groups were sacrificed at 16 months. Ultrafine sections of the right atrium were analyzed by electron microscopy. In elderly diabetic animals, histograms of the frequency distribution of natriuretic peptides according to their size showed increased number of small and medium peptides in relation to large peptides, which increased its numerical density leading to a decrease in the mean diameter of both natriuretic peptides. However, elderly diabetic animals remained normotensive. No significant difference was observed between the groups for the volume density of mitochondria, endoplasmic reticulum and Golgi apparatus. In conclusion, elderly diabetic rats showed increased functional activity of atrial cardiomyocytes with greater production of natriuretic peptides in association with a quantitative maintenance of cytoplasmic components.
  • Thoracic aortic dissection associated with involvement by small
           lymphocytic lymphoma / chronic lymphocytic leukemia: a possible
           underappreciated risk factor'
    • Abstract: Publication date: Available online 18 November 2019Source: Cardiovascular PathologyAuthor(s): Matthew L. Inra, Mathias G. McCormick, Gabor Bagameri, Peter T. Lin
  • Absent left atrial appendage: Case report and review of the literature
    • Abstract: Publication date: Available online 18 November 2019Source: Cardiovascular PathologyAuthor(s): Leili Pourafkari, Anita Sadeghpour, Aidin Baghbani-Oskouei, Safa Savadi-Oskouei, Hamidreza Pouraliakbar, Amir Farjam Fazelifar, Hamideh Khesali, Nader D. NaderAbstractCongenital absence of left atrial appendage (LAA) is an extremely rare condition and is usually diagnosed incidentally in imaging intended for other purposes. Herein, we report a rare case of absent LAA in an 80-year-old gentleman who was candidate for radiofrequency catheter ablation procedure for atrial flutter rhythm in whom we observed the absence of LAA in echocardiographic examination. CT angiographic examination performed in the evaluation course of the patient was also confirmative of this finding. As there is no data on anticoagulating of patients with absent LAA, after successful radiofrequency catheter ablation procedure, we continued rivaroxaban per guidelines. For diagnosing a patient with absent LAA, having the results of a second imaging modality as well as a thorough surgical and medical history is valuable in precise evaluation of the condition and ruling out imitating conditions such as surgical/percutaneous exclusion, unusual anatomical features or flush thrombotic occlusion of LAA. In this case report, we also provide a brief review of the characteristics of seventeen cases that have been reported in the literature so far.
  • Fibrotic Aortic Valve Disease after Radiotherapy: An Immunohistochemical
           Study in Breast Cancer and Lymphoma Patients
    • Abstract: Publication date: Available online 15 November 2019Source: Cardiovascular PathologyAuthor(s): Jan Willem van Rijswijk, Emile S. Farag, Carlijn VC. Bouten, Onno J de Boer, Allard van der Wal, Bas AJM de Mol, Jolanda KluinAbstractBackgroundRadiation-associated aortic valve (AV) stenosis is frequently seen as a late sequela after thoracic radiotherapy (RT). Although the clinical relationship between thoracic RT and valvular dysfunction has been established, the process leading to accelerated AV stenosis remains unclear. The aim of this study was to determine whether increased inflammatory cell infiltration, fibrosis, and calcification is present in AVs after RT at the time of AV replacement.MethodsStenotic AV specimens from 43 patients were obtained after surgical AV replacement. 28 patients had previously undergone RT for breast cancer or malignant lymphoma. 15 patients were included as control. The valve leaflets were assessed by (immuno) histochemistry for inflammatory cell composition (CD3, CD20, CD68, and CD163) and extracellular matrix changes (collagen and calcification).ResultsAV cell density after RT for lymphoma was markedly decreased when compared to other groups. Irradiated AV show similar (low) degrees of late T and B lymphocyte infiltration as control valves, while macrophage marker CD68 was decreased after RT for breast cancer. Collagen content was increased following RT. AVs of lymphoma patients contained significantly less calcified tissue when compared to the other groups.ConclusionHigh dose radiation at young age (lymphoma patients) results in cell loss and premature fibrotic AV stenosis as opposed to the degenerative calcific stenosis observed in breast cancer patients. Our findings suggest a possible dose-dependent effect of RT on AV fibrosis. The active presence of inflammatory cells may be limited to the acute phase after RT.
  • A Novel, Rapid, and Low Cost Method for Preparing Tissues with Metallic
           Stents for Routine Histology
    • Abstract: Publication date: Available online 15 November 2019Source: Cardiovascular PathologyAuthor(s): Dylan V. Miller, Tyler A. Jensen, Tami L. Bair, Thom JensenABSTRACTBackgroundCoronary artery stenting has become a common procedure and cardiovascular pathology specimens containing these metallic stents are accordingly becoming common. Histologic examination of stented vessels is imperative, but special techniques are needed due to the presence of metal within the tissue. We describe a rapid and inexpensive method for preparing stented vascular specimens for routine histology suitable for use in almost any histology laboratory.DesignAfter formalin fixation and decalcification, stented vascular segments were freeze-embedded and sectioned using a handheld power micro cutoff wheel tool into ∼1 mm slices. Sections were allowed to thaw and the strut shards removed with fine forceps. No longer containing metal, the sections were processed for routine paraffin embedding, microtomy and staining.ResultsHistologic sections showed only minor tissue disruption around the stent struts. In our experience with 25 stented arteries (mean interval from implantation 5. 6 years), the mean subjective section quality score was 4.1 out of 5. The position of each strut could easily be determined, along with neointimal in-stent restenosis and thrombosis. Local reaction to each strut could be surmised even if minor tissue disruption occurred. The entire process was completed in 2-3 days. The incremental cost over that of routine histology is nominal.ConclusionThis method for examining stented vascular segments histologically could readily be applied in most pathology laboratories and serves as a highly practical solution to dilemma of examining stents histologically.
  • Comparison of Heat Monitoring Based Myocardial Protection Strategy with
           Classic Myocardial Protection Method in Isolated Coronary Artery Bypass
           Surgery Patients
    • Abstract: Publication date: Available online 5 November 2019Source: Cardiovascular PathologyAuthor(s): Hüseyin Solğun, Farid Gojayev, Koray Ak, Ahmet Midi, Yasemin CanniogluAbstractObjectiveIn this study, we aimed to compare patients who have a myocardial protection strategy based on myocardial temperature monitorization with those who had myocardial protection with conventional intermittent cardioplegia.Methods26 patients undergoing coronary artery bypass graft surgery was included into the study. Patients were prospectively grouped into two; myocardial protection based on temperature monitoring (Group 1, n = 11) and those who had cardioplegia every 20 minutes (Group 2, n = 15) during aortic cross-clamping. In all patients, cold blood cardioplegia was used. Coronary sinus blood sampling was performed immediately before aortic cross-clamping, after 2, 20 and 40 minutes of aortic clamping and tumour necrosis factor-alpha, malondialdehyde, creatinine kinase (CK)-MB, troponin I, lactate and pH were studied. Also, myocardial biopsy was taken before and immediately after cross-clamping in order to evaluate cardiomyocyte apoptosis with caspase-3 Tunnel immunostaining.ResultsThere were no differences in clinical parameters like early mortality, extubation time, inotropic requirements, postoperative drainage, intensive care unit and hospitalization time between two groups. In addition, blood and blood products were similar in two groups. In group 2, after cross-clamping, Troponin I and CK-MB values were significantly higher than the other group. In myocardial biopsies, the caspase immunostaining score, before removal of aortic cross-clamp was significantly higher in group 2 compared to the samples taken before aortic clamping.ConclusionOur results show that there is no difference between temperature based myocardial protection strategy with conventional intermittent cardioplegia delivery.We think that the number of patients in our study is low and that the patient population is not a homogeneous structure is the most important limiting factor of our study. Increasing the number of patients, with particularly those who have myocardial dysfunction would help augment the possible different effects of two cardioplegic techniques on myocardial protection.
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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