Subjects -> MEDICAL SCIENCES (Total: 8679 journals)
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CARDIOVASCULAR DISEASES (338 journals)                  1 2 | Last

Showing 1 - 200 of 338 Journals sorted alphabetically
Acta Angiologica     Open Access   (Followers: 5)
Acta Cardiologica     Hybrid Journal   (Followers: 2)
Acute Cardiac Care     Hybrid Journal   (Followers: 8)
Adipositas - Ursachen, Folgeerkrankungen, Therapie     Hybrid Journal  
AJP Heart and Circulatory Physiology     Hybrid Journal   (Followers: 12)
Aktuelle Kardiologie     Hybrid Journal   (Followers: 1)
American Heart Journal     Hybrid Journal   (Followers: 60)
American Journal of Cardiology     Hybrid Journal   (Followers: 68)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 18)
American Journal of Hypertension     Hybrid Journal   (Followers: 29)
Anales de Cirugia Vascular     Full-text available via subscription   (Followers: 1)
Anatolian Journal of Cardiology     Open Access   (Followers: 6)
Angiología     Full-text available via subscription  
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1)
Angiology     Hybrid Journal   (Followers: 3)
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (Followers: 1)
Annals of Circulation     Open Access   (Followers: 2)
Annals of Noninvasive Electrocardiology     Hybrid Journal   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 12)
AORTA     Open Access  
Archives of Cardiovascular Diseases     Full-text available via subscription   (Followers: 6)
Archives of Cardiovascular Diseases Supplements     Full-text available via subscription   (Followers: 4)
Archives of Cardiovascular Imaging     Open Access   (Followers: 2)
Archivos de cardiología de México     Open Access   (Followers: 1)
Argentine Journal of Cardiology (English edition)     Open Access   (Followers: 2)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 2)
Arrhythmia & Electrophysiology Review     Open Access   (Followers: 1)
Arteriosclerosis, Thrombosis and Vascular Biology     Full-text available via subscription   (Followers: 33)
Artery Research     Hybrid Journal   (Followers: 5)
ARYA Atherosclerosis     Open Access  
ASAIO Journal     Hybrid Journal   (Followers: 4)
ASEAN Heart Journal     Open Access   (Followers: 3)
Asian Cardiovascular and Thoracic Annals     Hybrid Journal   (Followers: 2)
Aswan Heart Centre Science & Practice Services     Open Access   (Followers: 1)
Atherosclerosis : X     Open Access  
Bangladesh Heart Journal     Open Access   (Followers: 3)
Basic Research in Cardiology     Hybrid Journal   (Followers: 9)
BMC Cardiovascular Disorders     Open Access   (Followers: 22)
Brain Circulation     Open Access   (Followers: 1)
British Journal of Cardiology     Full-text available via subscription   (Followers: 18)
Canadian Journal of Cardiology     Hybrid Journal   (Followers: 18)
Cardiac Cath Lab Director     Full-text available via subscription  
Cardiac Electrophysiology Review     Hybrid Journal   (Followers: 2)
Cardiac Failure Review     Open Access   (Followers: 2)
Cardiocore     Full-text available via subscription   (Followers: 1)
Cardiogenetics     Open Access   (Followers: 3)
Cardiology     Full-text available via subscription   (Followers: 20)
Cardiology and Angiology: An International Journal     Open Access   (Followers: 1)
Cardiology and Therapy     Open Access   (Followers: 11)
Cardiology Clinics     Full-text available via subscription   (Followers: 14)
Cardiology in Review     Hybrid Journal   (Followers: 9)
Cardiology in the Young     Hybrid Journal   (Followers: 35)
Cardiology Journal     Open Access   (Followers: 6)
Cardiology Plus     Open Access   (Followers: 1)
Cardiology Research     Open Access   (Followers: 15)
Cardiology Research and Practice     Open Access   (Followers: 11)
Cardiopulmonary Physical Therapy Journal     Hybrid Journal   (Followers: 9)
Cardiorenal Medicine     Full-text available via subscription   (Followers: 1)
Cardiothoracic Surgeon     Open Access   (Followers: 1)
CardioVasc     Full-text available via subscription   (Followers: 1)
Cardiovascular & Haematological Disorders - Drug Targets     Hybrid Journal   (Followers: 1)
Cardiovascular & Hematological Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 2)
CardioVascular and Interventional Radiology     Hybrid Journal   (Followers: 15)
Cardiovascular and Thoracic Open     Open Access  
Cardiovascular Diabetology     Open Access   (Followers: 10)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 14)
Cardiovascular Endocrinology & Metabolism     Hybrid Journal   (Followers: 1)
Cardiovascular Engineering     Hybrid Journal   (Followers: 1)
Cardiovascular Engineering and Technology     Hybrid Journal   (Followers: 1)
Cardiovascular Intervention and Therapeutics     Hybrid Journal   (Followers: 5)
Cardiovascular Journal     Open Access   (Followers: 6)
Cardiovascular Journal of Africa     Full-text available via subscription   (Followers: 5)
Cardiovascular Journal of South Africa     Full-text available via subscription   (Followers: 2)
Cardiovascular Medicine in General Practice     Full-text available via subscription   (Followers: 7)
Cardiovascular Pathology     Hybrid Journal   (Followers: 4)
Cardiovascular Regenerative Medicine     Open Access  
Cardiovascular Research     Hybrid Journal   (Followers: 16)
Cardiovascular Revascularization Medicine     Hybrid Journal   (Followers: 1)
Cardiovascular System     Open Access  
Cardiovascular Therapeutics     Open Access   (Followers: 1)
Cardiovascular Toxicology     Hybrid Journal   (Followers: 6)
Cardiovascular Ultrasound     Open Access   (Followers: 5)
Case Reports in Cardiology     Open Access   (Followers: 7)
Catheterization and Cardiovascular Interventions     Hybrid Journal   (Followers: 3)
Cerebrovascular Diseases     Full-text available via subscription   (Followers: 3)
Cerebrovascular Diseases Extra     Open Access  
Chest     Full-text available via subscription   (Followers: 104)
Choroby Serca i Naczyń     Open Access   (Followers: 1)
Circulation     Hybrid Journal   (Followers: 270)
Circulation : Cardiovascular Imaging     Hybrid Journal   (Followers: 15)
Circulation : Cardiovascular Interventions     Hybrid Journal   (Followers: 19)
Circulation : Cardiovascular Quality and Outcomes     Hybrid Journal   (Followers: 12)
Circulation : Genomic and Precision Medicine     Hybrid Journal   (Followers: 17)
Circulation : Heart Failure     Hybrid Journal   (Followers: 28)
Circulation Research     Hybrid Journal   (Followers: 36)
Cirugía Cardiovascular     Open Access  
Clínica e Investigación en Arteriosclerosis     Full-text available via subscription  
Clínica e Investigación en arteriosclerosis (English Edition)     Hybrid Journal  
Clinical and Experimental Hypertension     Hybrid Journal   (Followers: 3)
Clinical Cardiology     Hybrid Journal   (Followers: 10)
Clinical Hypertension     Open Access   (Followers: 5)
Clinical Medicine Insights : Cardiology     Open Access   (Followers: 6)
Clinical Research in Cardiology     Hybrid Journal   (Followers: 5)
Clinical Research in Cardiology Supplements     Hybrid Journal  
Clinical Trials and Regulatory Science in Cardiology     Open Access   (Followers: 4)
Congenital Heart Disease     Hybrid Journal   (Followers: 6)
Congestive Heart Failure     Hybrid Journal   (Followers: 4)
Cor et Vasa     Full-text available via subscription   (Followers: 1)
Coronary Artery Disease     Hybrid Journal   (Followers: 3)
CorSalud     Open Access  
Critical Pathways in Cardiology     Hybrid Journal   (Followers: 5)
Current Cardiology Reports     Hybrid Journal   (Followers: 6)
Current Cardiology Reviews     Hybrid Journal   (Followers: 3)
Current Cardiovascular Imaging Reports     Hybrid Journal   (Followers: 1)
Current Cardiovascular Risk Reports     Hybrid Journal  
Current Heart Failure Reports     Hybrid Journal   (Followers: 5)
Current Hypertension Reports     Hybrid Journal   (Followers: 6)
Current Hypertension Reviews     Hybrid Journal   (Followers: 6)
Current Opinion in Cardiology     Hybrid Journal   (Followers: 13)
Current Problems in Cardiology     Hybrid Journal   (Followers: 3)
Current Research : Cardiology     Full-text available via subscription   (Followers: 1)
Current Treatment Options in Cardiovascular Medicine     Hybrid Journal   (Followers: 1)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 5)
CVIR Endovascular     Open Access   (Followers: 1)
Der Kardiologe     Hybrid Journal   (Followers: 1)
Echo Research and Practice     Open Access   (Followers: 2)
Echocardiography     Hybrid Journal   (Followers: 4)
Egyptian Heart Journal     Open Access   (Followers: 2)
Egyptian Journal of Cardiothoracic Anesthesia     Open Access  
ESC Heart Failure     Open Access   (Followers: 4)
European Cardiology Review     Open Access   (Followers: 1)
European Heart Journal     Hybrid Journal   (Followers: 68)
European Heart Journal - Cardiovascular Imaging     Hybrid Journal   (Followers: 10)
European Heart Journal - Cardiovascular Pharmacotherapy     Full-text available via subscription   (Followers: 2)
European Heart Journal - Quality of Care and Clinical Outcomes     Hybrid Journal  
European Heart Journal : Acute Cardiovascular Care     Hybrid Journal   (Followers: 1)
European Heart Journal : Case Reports     Open Access   (Followers: 1)
European Heart Journal Supplements     Hybrid Journal   (Followers: 7)
European Journal of Cardio-Thoracic Surgery     Hybrid Journal   (Followers: 9)
European Journal of Cardio-Thoracic Surgery Supplements     Full-text available via subscription   (Followers: 2)
European Journal of Cardiovascular Nursing     Hybrid Journal   (Followers: 5)
European Journal of Heart Failure     Hybrid Journal   (Followers: 13)
European Journal of Preventive Cardiology.     Hybrid Journal   (Followers: 6)
European Stroke Organisation     Hybrid Journal   (Followers: 3)
Experimental & Translational Stroke Medicine     Open Access   (Followers: 9)
Expert Review of Cardiovascular Therapy     Full-text available via subscription   (Followers: 3)
Folia Cardiologica     Open Access  
Forum Zaburzeń Metabolicznych     Hybrid Journal  
Frontiers in Cardiovascular Medicine     Open Access   (Followers: 1)
Future Cardiology     Hybrid Journal   (Followers: 5)
General Thoracic and Cardiovascular Surgery     Hybrid Journal   (Followers: 3)
Global Cardiology Science and Practice     Open Access   (Followers: 5)
Global Heart     Hybrid Journal   (Followers: 3)
Heart     Hybrid Journal   (Followers: 49)
Heart and Mind     Open Access  
Heart and Vessels     Hybrid Journal  
Heart Failure Clinics     Full-text available via subscription   (Followers: 2)
Heart Failure Reviews     Hybrid Journal   (Followers: 3)
Heart India     Open Access   (Followers: 2)
Heart International     Full-text available via subscription  
Heart Rhythm     Hybrid Journal   (Followers: 11)
Heart Views     Open Access   (Followers: 2)
HeartRhythm Case Reports     Open Access  
Hellenic Journal of Cardiology     Open Access   (Followers: 1)
Herz     Hybrid Journal   (Followers: 2)
High Blood Pressure & Cardiovascular Prevention     Full-text available via subscription   (Followers: 2)
Hypertension     Full-text available via subscription   (Followers: 24)
Hypertension     Open Access   (Followers: 2)
Hypertension in Pregnancy     Hybrid Journal   (Followers: 9)
Hypertension Research     Hybrid Journal   (Followers: 4)
Ibrahim Cardiac Medical Journal     Open Access  
IJC Heart & Vessels     Open Access   (Followers: 1)
IJC Heart & Vasculature     Open Access   (Followers: 1)
IJC Metabolic & Endocrine     Open Access   (Followers: 1)
Indian Heart Journal     Open Access   (Followers: 5)
Indian Journal of Cardiovascular Disease in Women WINCARS     Open Access  
Indian Journal of Thoracic and Cardiovascular Surgery     Hybrid Journal  
Indian Pacing and Electrophysiology Journal     Open Access   (Followers: 1)
Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery     Hybrid Journal   (Followers: 1)
Insuficiencia Cardíaca     Open Access  
Interactive CardioVascular and Thoracic Surgery     Hybrid Journal   (Followers: 6)
International Cardiovascular Forum Journal     Open Access  
International Journal of Angiology     Hybrid Journal   (Followers: 2)
International Journal of Cardiology     Hybrid Journal   (Followers: 17)
International Journal of Cardiology Hypertension     Open Access   (Followers: 1)
International Journal of Cardiovascular and Cerebrovascular Disease     Open Access   (Followers: 3)
International Journal of Cardiovascular Imaging     Hybrid Journal   (Followers: 2)
International Journal of Cardiovascular Research     Hybrid Journal   (Followers: 6)
International Journal of Heart Rhythm     Open Access  
International Journal of Hypertension     Open Access   (Followers: 8)
International Journal of Hyperthermia     Open Access  
International Journal of Stroke     Hybrid Journal   (Followers: 33)
International Journal of the Cardiovascular Academy     Open Access  
Interventional Cardiology Clinics     Full-text available via subscription   (Followers: 2)
Interventional Cardiology Review     Open Access  
JACC : Basic to Translational Science     Open Access   (Followers: 6)
JACC : Cardiovascular Imaging     Hybrid Journal   (Followers: 19)
JACC : Cardiovascular Interventions     Hybrid Journal   (Followers: 21)
JACC : Heart Failure     Full-text available via subscription   (Followers: 16)
JAMA Cardiology     Hybrid Journal   (Followers: 32)

        1 2 | Last

Similar Journals
Journal Cover
Journal Prestige (SJR): 0.322
Citation Impact (citeScore): 1
Number of Followers: 2  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1615-6692 - ISSN (Online) 0340-9937
Published by Springer-Verlag Homepage  [2626 journals]
  • Mirror-image dextrocardia: why is the apex impulse not on the right'
    • Abstract: Abstract This article presents the case of an 11-year-old girl with a history of Fortan surgery who presented to the authors’ department with shortness of breath, orthopnea, and cyanosis. Electrocardiography (ECG) was indicative of mirror-image dextrocardia despite location of the apex impulse on the left. Echocardiography suggested mirror-image dextrocardia accompanied by levoversion, a large atrial septal defect and left ventricular atresia (functional single atrium and single ventricle), and right ventricular hypertrophy. ECG with corrected leads placement showed a sinus rhythm, biatrail enlargement, and right ventricular hypertrophy. Based on echocardiography and medical history, the case was rediagnosed as mirror-image dextrocardia with levoversion.
      PubDate: 2020-08-06
  • Erratum to: Efficacy of liraglutide intervention in myocardial infarction
    • Abstract: Erratum to: Herz 2018 In the above mentioned article, the affiliations of the authors and the corresponding address were not given correctly. The correct affiliations/address of correspondence is as follows: X. Yang1,2, Z. Liang1 1 Department of Respiratory …
      PubDate: 2020-08-01
  • Noninvasive functional testing after ISCHEMIA: gatekeeper or phased-out
    • PubDate: 2020-08-01
  • Outcomes of anatomical vs. functional testing for coronary artery disease
    • Abstract: Abstract Management of patients presenting with suspected stable coronary artery disease (CAD) are challenging because estimation of pretest probability for obstructive CAD remains difficult. In addition, identification of those who benefit from coronary revascularization remains ineffective regardless of the wide array of noninvasive testing alternatives available. Functional testing, which has long been considered to be the test of choice to risk stratify these patients, shows modest agreement with CAD severity detected by invasive coronary angiography and has been reported to be ineffective in settings of low prevalence of obstructive CAD. A growing body of evidence demonstrates the excellent diagnostic accuracy as well as prognostic value of coronary computed tomography (CT) angiography especially in conjunction with noninvasive fractional flow reserve (FFR) testing, challenging the primary role of functional testing especially in patients without prior or known CAD. Landmark trials, including the Prospective Multicenter Imaging Study for Evaluation of chest pain (PROMISE) and Scottish Computed Tomography of the Heart (SCOT-HEART), have contributed to a better understanding of how coronary CT angiography may play a role in more efficient management and even improved health outcomes. The emerging role of coronary CT has been acknowledged by the 2019 Guidelines of the European Society of Cardiology recommending the use of CT as a first-line tool for the evaluation of patients with stable chest pain with a class I, level of evidence B recommendation. The purpose of this article is to provide an overview on existing evidence, clinical implication, limitations of available data, and remaining questions to be answered by future research.
      PubDate: 2020-08-01
  • Lipidprofil und kardiovaskuläres Risiko der Teilnehmer an den
           Lipidmesstagen im Industriepark Höchst
    • Abstract: Zusammenfassung Hintergrund Kardiovaskuläre (CV-)Erkrankungen stellen nach wie vor die häufigste Todesursache in den Industrienationen dar. Arbeitgeberinitiierte Screenings des kardiovaskulären Risikos könnten bereits frühzeitig zur Optimierung der Präventionsstrategien beitragen. Methoden In einer Querschnittsanalyse wurde das CV-Risikoprofil (Dyslipidämie, Hypertonie, Rauchen, Diabetes mellitus und familiäre Disposition) von 1436 Arbeitnehmern des Industrieparks Frankfurt-Höchst analysiert. Das Gesamtrisiko wurde mit dem PROCAM-SCORE ermittelt. Ergebnisse Bei 36 % der Teilnehmer wurde eine Hypercholesterinämie (LDL[„low-density lipoprotein“]: >130 mg/dl) festgestellt. 23,7 % (n = 9/38) der Hochrisikopatienten (Myokardinfarkt/Apoplex und/oder Diabetes) lagen im von der European Society of Cardiology (ESC) definierten Zielwertbereich für LDL von unter 70 mg/dl, 18,4 % (n = 7) wiesen Werte zwischen 70 und 100 mg/dl und 57,9 % des Hochrisikokollektivs (n = 22) Werte von mehr als 100 mg/dl auf. Zudem zeigte mehr als die Hälfte der Probanden (53,2 %) erhöhte Blutdruckwerte (definiert als systolischer Blutdruck ≥140 mm Hg und/oder diastolisch ≥90 mm Hg). Die Diabetesprävalenz (Blutzucker: >126 mg/dl) war mit 1,3 % sehr niedrig wie auch die Häufigkeit manifester CV-Erkrankungen (1,4 % Myokardinfarkt oder Apoplex, 2,9 % stabile Angina pectoris oder pAVK). Schlussfolgerung Die Daten bestätigen, dass die Risikofaktoren Bluthochdruck und Dyslipidämie weit verbreitet sind und die Zielwerterreichung insbesondere bei hohem CV-Risiko unzureichend ist. Es sollten verhaltenstherapeutische und/oder medikamentöse Maßnahmen genutzt werden, um das hohe Präventionspotenzial für Träger dieser Risikofaktoren besser auszuschöpfen.
      PubDate: 2020-08-01
  • Werden die Karten der CT-Koronarangiographie mit der FFR CT neu
    • Abstract: Zusammenfassung Die koronare Computertomographie-Angiographie (CCTA) besitzt, insbesondere aufgrund ihres hohen negativen prädiktiven Werts und der hohen Sensitivität, bereits einen hohen Stellenwert in der Primärdiagnostik der koronaren Herzkrankheit (KHK) bei allerdings limitierter Spezifität. Invasiv lässt sich die Spezifität der Herzkatheteruntersuchung (HKU) mit der „fractional flow reserve“ (FFR) mittels Nachweises der hämodynamischen Relevanz einer morphologisch nachgewiesenen Koronarstenose gut erhöhen. Neue, entweder auf „computational fluid dynamics“ (CFD) oder „machine learning“ (ML) basierende, nicht-invasive Methoden der FFR-Bestimmung in der CT (FFRCT) zeigen vielversprechende Ergebnisse. Die Möglichkeit des Einsatzes der CCTA wird aber v. a. von der Bildqualität und der Möglichkeit einer guten Segmentierung der Koronararterien bestimmt, die in 7–12 % der CCTA für die Anwendung der FFRCT nicht ausreicht, obwohl eine rein morphologische Beurteilung meist möglich ist. Beim Verschluss eines Koronargefäßes, z. B. zur Beurteilung des Kollateralflusses, kann die FFRCT ebenfalls nicht angewendet werden. Die FFRCT ist somit allein kein „game changer“ bei der Diagnose der chronischen KHK („chronic conorary syndrome“, CCS), sondern vielmehr ist es der ergänzende Einsatz zur CCTA bei nicht eindeutigen Fällen. Außerdem gibt es bisher nur einen kommerziellen Anbieter der FFRCT, bei dem die Analyse zeitlich verzögert („off-site“) erfolgt, was den akuten Nutzen bisher noch einschränkt. Es gibt allerdings auch On-site-Lösungen, die jedoch bisher nur für wissenschaftliche Zwecke und nicht klinisch eingesetzt werden dürfen. Eine sinnvolle Ergänzung zur rein morphologischen Beurteilung stellt die FFRCT aber auf jeden Fall dar. Wenn On-site-FFRCT-Lösungen auch kommerziell verfügbar sind, werden sie die Wertigkeit der CCTA im klinischen Alltag zur Primärdiagnostik des CCS in jedem Fall noch weiter erhöhen helfen.
      PubDate: 2020-08-01
  • ESC 2019 guidelines for the diagnosis and management of chronic coronary
    • Abstract: Abstract The European Society of Cardiology (ESC) has recently published new guidelines on the diagnosis and management of chronic coronary syndromes (CCS). Due to variable symptoms, objective tests are often necessary to confirm the diagnosis, exclude alternative diagnoses, and assess the severity of underlying disease. This review provides a summary of the main diagnostic strategies listed in the guidelines for evaluation of patients suspected of having obstructive coronary artery disease (CAD). Based on data from contemporary cohorts of patients referred for diagnostic testing, the pre-test probabilities of obstructive CAD based on age, sex, and symptoms have been adjusted substantially downward compared with the previous guidelines. Further, a new concept of “clinical likelihood of CAD” was introduced accounting for the impact of various risk factors and modifiers on the pre-test probability. Noninvasive functional imaging for myocardial ischemia, coronary computed tomography angiography, or invasive coronary angiography combined with functional evaluation is recommended as the initial strategy to diagnose CAD in symptomatic patients, unless obstructive CAD can be excluded by clinical assessment alone. When available, imaging tests are recommended as noninvasive modalities instead of exercise electrocardiograms.
      PubDate: 2020-08-01
  • Health-related quality of life in adult heart-transplant
           recipients—a systematic review
    • Abstract: Background Health-related quality of life is a multidimensional concept to assess the impact of medical interventions from an individual perspective. This concept is important to evaluate benefits of heart transplantation. This systematic review was conducted to determine (1) posttransplant health-related quality of life in heart transplantation patients and (2) influencing factors of health-related quality of life. Methods A systematic review of cross-sectional, prospective and mixed methods studies published from November 2007 to November 2017 was conducted on PsycINFO, PSYNDEX and PubMed using a combination of the keywords heart transplantation, heart transplantation patient, quality of life, and health-related quality of life. Results A total of 14 studies with a cross-sectional design, 6 studies with a prospective design and 2 mixed-methods studies were identified. The stability of health-related quality of life up to 10 years after transplantation has been reported. Most often generic scales, such as SF-36 (8) and WHOQoL-BREF (7) were used for data collection. Demoralization, depression, pain, gastrointestinal symptoms, sexual dysfunction, and poor oral health influence health-related quality of life negatively, whereas social and family support have a positive impact. Conclusion Although health-related quality of life is positively influenced by transplantation, further research regarding gender differences is needed. Disease-specific scales were rarely used.
      PubDate: 2020-08-01
  • Efficacy of liraglutide intervention in myocardial infarction
    • Abstract: Introduction The efficacy of liraglutide intervention for myocardial infarction (MI) remains controversial. We conducted a systematic review and meta-analysis to explore the influence of liraglutide intervention versus placebo on cardiac function for MI. Methods We searched PubMed, Embase, Web of science, EBSCO, and Cochrane library databases through April 2018 for randomized controlled trials (RCTs) assessing the effect of liraglutide intervention versus placebo on MI. This meta-analysis was performed using the random-effect model. Results Four randomized controlled trials involving 469 patients were included in the meta-analysis. Overall, compared with control group for MI, liraglutide intervention significantly improved left ventricular ejection fraction (mean difference [MD] = 4.42; 95% confidence interval [CI] =1.71 to 7.14; P = 0.001), superoxide dismutase (MD = 6.89; 95% CI = 1.80 to 11.98; P = 0.008), and decreased high-sensitivity C‑reactive protein (MD = −0.21; 95% CI = −0.33 to −0.09; P = 0.0006), but had no remarkable influence on major adverse cardiovascular events (risk ratio = 0.56; 95% CI = 0.28–1.09; P = 0.09), recurrence of MI (risk ratio = 0.50; 95% CI = 0.19–1.30; P = 0.16), repeated revascularization (risk ratio = 0.49; 95% CI = 0.17–1.42; P = 0.19), and cardiac death (risk ratio = 0.57; 95% CI = 0.12–2.73; P = 0.48). Conclusions Liraglutide intervention is associated with significantly improved left ventricular ejection fraction and superoxide dismutase, reduced high-sensitivity C‑reactive protein in patients with MI, but has no remarkable impact on major adverse cardiovascular events, recurrence of MI, repeated revascularization or cardiac death.
      PubDate: 2020-08-01
  • After ISCHEMIA: is invasive physiology the only remaining gatekeeper for
           myocardial revascularization in chronic coronary syndromes'
    • Abstract: Abstract The International Study of Comparative Health Effectiveness With Medical And Invasive Approaches (ISCHEMIA) has the potential to be a game changer in terms of the diagnostic and management approach to patients presenting with chronic coronary syndrome, suggesting that coronary revascularization may become almost like a “bail-out” strategy in the treatment of these patients. However, invasive perfusion assessment as a means of detecting the source of myocardial ischaemia at a lesion level, such as fractional flow reserve (FFR), has been validated in the past and established beyond doubt as a key diagnostic tool. The complementary role of the two approaches will be discussed here.
      PubDate: 2020-08-01
  • After ISCHEMIA: Is cardiac MRI a reliable gatekeeper for invasive
           angiography and myocardial revascularization'
    • Abstract: Abstract This review surveys the findings of the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial and puts them into a clinical perspective regarding its effect of the role of cardiac magnetic resonance imaging (CMR) as a well-validated gatekeeper for invasive angiography and myocardial revascularization. Noninvasive stress testing of patients with intermediate-to-high pretest likelihood for obstructive coronary artery disease (CAD) using perfusion CMR provides excellent diagnostic accuracy in detecting ischemic myocardium, and additional information from tissue characterization can guide the management of patients with stable angina toward a more individualized therapy as other non-coronary underlying causes of chest pain can be detected. Since ISCHEMIA failed to show that an invasive strategy using percutaneous coronary intervention or coronary artery bypass grafting was associated with an improved prognosis compared with initial conservative medical therapy among stable patients with moderate-to-severe ischemia, CMR as a multifaceted diagnostic imaging approach to explain patients’ symptoms should be preferred over anatomical and stress testing alone. Nevertheless, the exclusion of left main coronary artery stenosis either by coronary CT or MR angiography may be required. In conclusion, the results of the ISCHEMIA trial are in good accordance with those of the MR-INFORM trial recently published in the New England Journal of Medicine, as the noninvasive management of a large proportion of patients with CAD was shown to be noninferior to current invasive strategies. Recent outcome data from trials may therefore have an impact on future guidelines to further reduce the execution of unnecessary left heart catheterizations.
      PubDate: 2020-08-01
  • Cardiac rehabilitation therapy for coronary slow flow phenomenon
    • Abstract: Objective To evaluate the effectiveness of cardiac rehabilitation on coronary slow flow phenomenon. Method Included were 30 consecutive patients from June 2015 to June 2017. A thrombolysis in myocardial infarction (TIMI) frame evaluation was used to estimate coronary blood flow velocity. All coronary angiography diameters were normal, but blood flow levels did not reach the TIMI level 3. All patients were treated with aspirin and rosuvastatin. Patients were randomly assigned to an experimental group (cardiac rehabilitation treatment group, n = 15) or a control group (normal treatment without cardiac rehabilitation, n = 15). Plasma low density lipoprotein cholesterol (LDL-C), triglyceride (TG), high-sensitivity C reactive protein (hs-CRP), homocysteine (Hcy) and arginine (Arg) expression levels were collected after admission. These indices were reviewed again after 20–30 weeks, improved subjective symptoms were evaluated by multiple outcome criteria (MOCs), and coronary angiography was used to evaluate the velocity of coronary artery blood flow. Result The expression levels of LDL-C and TG in the experimental group were significantly lower than those of the control group (both P < 0.01). The plasma levels of hs-CRP, Hcy and Arg were lower than those in the control group (all P < 0.01). In the experimental group, subjective symptoms of chest pain were significantly improved and the coronary artery blood flow velocity was significantly increased compared with the control group (P < 0.01). Conclusion Cardiac rehabilitation can reduce the plasma levels of LDL-C, TG, hs-CRP, Hcy and Arg, significantly improve the symptoms of coronary slow flow phenomenon and accelerate the speed of coronary artery blood flow.
      PubDate: 2020-08-01
  • New oral anticoagulants for nonvalvular atrial fibrillation with
           peripheral artery disease: a meta-analysis
    • Abstract: Background New oral anticoagulants (NOACs) are as effective and safe as warfarin for patients with non-valvular atrial fibrillation (NVAF). Limited evidence is available regarding outcomes for NVAF patients with peripheral artery disease (PAD). Methods A systematic search of Medline, Embase, and the Cochrane Library was performed. Two reviewers independently performed data extraction and quality assessment using the Cochrane Collaboration tool for assessing risk of bias. All primary publications and secondary analyses comparing NOACs with other oral anticoagulation regimens for the prevention of stroke in patients with both NVAF and PAD from phase III clinical trials were evaluated. The primary outcomes were stroke, systemic embolism (SE), major bleeding, and intracranial hemorrhage (ICH), and the secondary outcomes were cardiovascular (CV) mortality, all-cause mortality, and myocardial infarction (MI). Results Three articles were included in this study. The pooled results showed a relative risk for stroke/SE with NOACs of 0.86 (95% confidence interval [CI]: 0.53–1.39), for major bleeding, 1.12 (95% CI: 0.70–1.81), for ICH, 0.47 (95% CI: 0.16–1.36), for CV mortality, 0.77 (95% CI: 0.57–1.04), for all-cause mortality, 0.91 (95% CI: 0.70–1.19), and for MI, 1.10 (95% CI: 0.64–1.90). Conclusion The findings show that NOACs are effective and safe for preventing stroke/SE in patients with both NVAF and PAD.
      PubDate: 2020-07-29
  • Erratum to: Outcomes of anatomical vs. functional testing for coronary
           artery disease
    • Abstract: In the above-mentioned article, in the section “Other randomized controlled studies, meta-analyses, and registry data” two subheadings were swapped by mistake. The sections concerned must instead be headed as …
      PubDate: 2020-07-06
  • Troponinerhöhung beim akuten ischämischen Schlaganfall – unspezifisch
           oder Ausdruck eines akuten Myokardinfarkts'
    • Abstract: Zusammenfassung Für alle Patienten mit akutem ischämischen Schlaganfall wird die routinemäßige Troponinbestimmung empfohlen. Bei 20–55 % dieser Patienten ist der Troponinwert erhöht, wobei hierfür neben der ischämischen auch die nichtischämische Myokardschädigung sowie im Besonderen der neurokardiogene Myokardschaden ursächlich sein können. Bei Patienten mit akutem ischämischen Schlaganfall wird die Prävalenz einer bisher nicht bekannten koronaren Herzkrankheit mit bis zu 27 % angegeben und ist für dieses Kollektiv prognosebestimmend. Allerdings können bei Schlaganfallpatienten mit Troponinerhöhung im Vergleich zu Patienten mit einem Nicht-ST-Strecken-Hebungs-Myokardinfarkt seltener relevante Koronarstenosen nachgewiesen werden. Das Risiko einer sekundären intrazerebralen Hämorrhagie durch die Notwendigkeit einer dualen Thrombozytenaggregationshemmung verdeutlicht die herausfordernde Indikationsstellung zur invasiven Koronardiagnostik und -revaskularisation. Daher sind eine der Dringlichkeit angemessene diagnostische Aufarbeitung und interdisziplinäre Risikoevaluation notwendig, um ein sinnvolles therapeutisches Vorgehen mit Zeitpunkt der Intervention sowie Art und Dauer der Blutverdünnung festlegen zu können. Neben konventionellen Untersuchungsmethoden steht hierfür immer häufiger auch eine erweiterte kardiale Bildgebung zur Verfügung. Diese Übersichtsarbeit möchte einen pragmatischen und klinisch orientierten Ansatz zum diagnostischen und therapeutischen Vorgehen unter Berücksichtigung der vorhandenen Evidenz aufzeigen.
      PubDate: 2020-07-06
  • Therapeutisches Management des nichtvalvulären Vorhofflimmerns
    • Abstract: Zusammenfassung Vorhofflimmern (VHF) ist die häufigste anhaltende Herzrhythmusstörung und mit einer erhöhten Mortalität assoziiert, sodass eine effektive Differenzialtherapie der Patienten notwendig ist. Nach Risikostratifikation muss, abhängig vom individuellen Schlaganfallrisiko, eine orale Antikoagulation (OAK) eingeleitet werden. Insbesondere bei Kontraindikationen für eine OAK und hohem Blutungs- und/oder Schlaganfallrisiko kann alternativ die Implantation eines Vorhofohrverschlusssystems erwogen werden. Symptomatische Patienten sollten möglichst einer Rhythmuskontrolle zugeführt werden. Hier spielt die Katheterablation (KA) aufgrund der Nutzen-Risiko-Abwägung, auch im Hinblick auf eine dauerhafte medikamentöse Therapie, eine zunehmend große Rolle. Durch eine Pulmonalvenenisolation kann bei einem paroxysmalen VHF mit einer Einjahres-VHF-Freiheitsrate von etwa 70–80 % gerechnet werden. Ein Überlebensvorteil konnte bislang lediglich bei Patienten mit Herzinsuffizienz für die KA nachgewiesen werden, sodass es sich hierbei meist um eine symptomatische Therapie zur Verbesserung der Lebensqualität handelt.
      PubDate: 2020-07-06
  • After ISCHEMIA: Is coronary CTA the new gatekeeper'
    • Abstract: Abstract The ISCHEMIA trial investigated two major principles in the therapy of coronary artery disease (CAD), i.e., symptom relief and improvement of prognosis. Specifically, it was designed to answer the question of whether, after ruling out left main stenosis, a routine interventional strategy in addition to optimal medical therapy can improve clinical outcome. Overall, this hypothesis could not be confirmed. Nevertheless, the trial yields interesting new aspects in the field of cardiac imaging. As a noninvasive diagnostic approach for individuals with suspected coronary artery disease, two different concepts are available: stress testing for ischemia (single-photon emission computed tomography, positron emission tomography, cardiac magnetic resonance imaging, stress echocardiography) and anatomic visualization of coronary artery stenosis by coronary computed tomography (CT) angiography (coronary CTA). While there was no randomized comparison between these two approaches in ISCHEMIA, the good outcome achieved by using coronary CTA as a “gatekeeper” to randomization supports the potential of coronary CTA as a diagnostic tool—both as first- and as second-line—when CAD is suspected. However, the trial also raises new questions in the field of cardiac imaging that need to be addressed in future studies.
      PubDate: 2020-07-03
  • Erratum to: After ISCHEMIA: Is cardiac MRI a reliable gatekeeper for
           invasive angiography and myocardial revascularization'
    • Abstract: In the above mentioned article, the family name of the second author was not given correctly: it is Carerj instead of Careri. The authors apologize for this mistake. The original article has been …
      PubDate: 2020-07-01
  • Neue orale Antidiabetika
    • Abstract: Zusammenfassung In den letzten Jahren hat sich die Therapie des Typ-2-Diabetes durch die Einführung neuer oraler Antidiabetika komplett geändert. Kardiovaskuläre Endpunktstudien belegen die Sicherheit der Dipeptidylpeptidase(DPP)-4-Hemmer und eine kardiovaskuläre Protektion bei GLP(„glucagon-like peptide“)-1-Rezeptor-Agonisten und SGLT2(„sodium-glucose linked transporter 2“)-Hemmern. Die SGLT2-Hemmer reduzieren zusätzlich das Risiko für eine Herzinsuffizienz und haben einen renoprotektiven Effekt. Dies hat zu neuen klinischen Empfehlungen und Leitlinien geführt. Bei Patienten mit hohem und sehr hohem kardiorenalen Risiko werden zur Risikoprotektion unabhängig vom glykosylierten Hämoglobin (HbA1c) SGLT2-Hemmer oder GLP-1-Rezeptor-Agonisten empfohlen, bei bestehendem oder hohem Risiko für eine Herzinsuffizienz SGLT2-Hemmer. Damit steht bei der Wahl der antidiabetischen Therapiestrategie nicht mehr allein die Höhe des HbA1c, sondern v. a. das kardiorenale Risiko im Vordergrund.
      PubDate: 2020-06-29
  • Myocarditis in the era of SARS-CoV-2: one piece of a complex
    • PubDate: 2020-06-08
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