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ALLERGOLOGY AND IMMUNOLOGY (216 journals)                  1 2 | Last

Showing 1 - 200 of 216 Journals sorted alphabetically
Acta Microbiologica et Immunologica Hungarica     Full-text available via subscription   (Followers: 5)
Advances in Immunology     Full-text available via subscription   (Followers: 39)
AIDS Research and Therapy     Open Access   (Followers: 15)
Alergologia Polska : Polish Journal of Allergology     Full-text available via subscription   (Followers: 2)
Allergies     Open Access   (Followers: 2)
Allergo Journal     Full-text available via subscription   (Followers: 2)
Allergo Journal International     Hybrid Journal   (Followers: 2)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1)
Allergology International     Open Access   (Followers: 5)
Allergy     Hybrid Journal   (Followers: 50)
Allergy & Rhinology     Open Access   (Followers: 4)
Allergy and Asthma Proceedings     Full-text available via subscription   (Followers: 14)
Allergy, Asthma and Clinical Immunology     Open Access   (Followers: 26)
American Journal of Epidemiology     Hybrid Journal   (Followers: 220)
American Journal of Immunology     Open Access   (Followers: 23)
American Journal of Preventive Medicine     Hybrid Journal   (Followers: 29)
American Journal of Reproductive Immunology     Hybrid Journal   (Followers: 6)
American Journal of Rhinology and Allergy     Hybrid Journal   (Followers: 9)
Annals of Allergy, Asthma and Immunology     Hybrid Journal   (Followers: 14)
Annals of Allergy, Asthma, and Immunology     Hybrid Journal  
Annual Review of Immunology     Full-text available via subscription   (Followers: 51)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 5)
Applied Immunohistochemistry & Molecular Morphology     Hybrid Journal   (Followers: 17)
Archives of Asthma, Allergy and Immunology     Open Access  
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2)
Autoimmune Diseases     Open Access   (Followers: 3)
Autoimmunity     Hybrid Journal   (Followers: 9)
Autoimmunity Highlights     Open Access   (Followers: 2)
Autoimmunity Reviews     Hybrid Journal   (Followers: 3)
BMC Immunology     Open Access   (Followers: 11)
Cancer Immunology, Immunotherapy     Hybrid Journal   (Followers: 22)
Case Reports in Immunology     Open Access   (Followers: 6)
Cellular & Molecular Immunology     Hybrid Journal   (Followers: 15)
Cellular Immunology     Hybrid Journal   (Followers: 31)
Chronic Diseases and Injuries in Canada     Free   (Followers: 1)
Clinica Chimica Acta     Hybrid Journal   (Followers: 28)
Clinical & Experimental Allergy     Hybrid Journal   (Followers: 7)
Clinical & Experimental Allergy Reviews     Hybrid Journal   (Followers: 1)
Clinical & Experimental Immunology     Hybrid Journal   (Followers: 18)
Clinical & Translational Immunology     Open Access   (Followers: 8)
Clinical and Experimental Neuroimmunology     Hybrid Journal   (Followers: 1)
Clinical and Molecular Allergy     Open Access   (Followers: 5)
Clinical and Translational Allergy     Open Access   (Followers: 2)
Clinical Immunology     Hybrid Journal   (Followers: 25)
Clinical Immunology, Endocrine & Metabolic Drugs     Hybrid Journal  
Clinical Reviews in Allergy and Immunology     Hybrid Journal   (Followers: 12)
Comparative Immunology, Microbiology and Infectious Diseases     Hybrid Journal   (Followers: 14)
Critical Reviews in Immunology     Full-text available via subscription   (Followers: 15)
Current Allergy & Clinical Immunology     Open Access   (Followers: 8)
Current Allergy and Asthma Reports     Hybrid Journal   (Followers: 2)
Current Immunology Reviews     Hybrid Journal   (Followers: 10)
Current Opinion in Allergy and Clinical Immunology     Hybrid Journal   (Followers: 8)
Current Opinion in Immunology     Hybrid Journal   (Followers: 44)
Current Opinion in Virology     Hybrid Journal   (Followers: 1)
Current Protocols in Immunology     Hybrid Journal  
Current Treatment Options in Allergy     Hybrid Journal   (Followers: 2)
Developmental & Comparative Immunology     Hybrid Journal   (Followers: 7)
Egyptian Journal of Pediatric Allergy and Immunology     Open Access   (Followers: 2)
Emerging Infectious Diseases     Open Access   (Followers: 30)
Epidemiologic Methods     Hybrid Journal   (Followers: 4)
European Annals of Allergy and Clinical Immunology     Open Access   (Followers: 5)
European Journal of Immunology     Hybrid Journal   (Followers: 39)
European Journal of Microbiology and Immunology     Open Access   (Followers: 11)
Expert Review of Clinical Immunology     Full-text available via subscription   (Followers: 5)
Expert Review of Vaccines     Full-text available via subscription   (Followers: 4)
Food and Agricultural Immunology     Open Access   (Followers: 2)
Frontiers in Immunology     Open Access   (Followers: 20)
Future Virology     Hybrid Journal   (Followers: 8)
Genes & Immunity     Hybrid Journal   (Followers: 8)
Global Journal of Allergy     Open Access   (Followers: 1)
Handbook of Systemic Autoimmune Diseases     Full-text available via subscription   (Followers: 2)
HLA Immune Response Genetics     Hybrid Journal  
HNO Nachrichten     Full-text available via subscription  
Human Immunology     Hybrid Journal   (Followers: 18)
Human Vaccines & Immunotherapeutics     Full-text available via subscription   (Followers: 2)
Hypersensitivity     Open Access   (Followers: 1)
Immunity     Full-text available via subscription   (Followers: 66)
Immunity & Ageing     Open Access   (Followers: 10)
Immunity, Inflammation and Disease     Open Access   (Followers: 6)
Immuno-analyse & Biologie Spécialisée     Full-text available via subscription   (Followers: 2)
Immunobiology     Hybrid Journal   (Followers: 9)
Immunoendocrinology     Open Access   (Followers: 1)
Immunogenetics     Hybrid Journal   (Followers: 6)
ImmunoHorizons     Open Access  
Immunologic Research     Hybrid Journal   (Followers: 6)
Immunological Investigations: A Journal of Molecular and Cellular Immunology     Hybrid Journal   (Followers: 2)
Immunological Medicine     Open Access  
Immunological Reviews     Hybrid Journal   (Followers: 27)
Immunology     Hybrid Journal   (Followers: 38)
Immunology & Cell Biology     Hybrid Journal   (Followers: 9)
Immunology and Allergy Clinics of North America     Full-text available via subscription   (Followers: 6)
Immunology and Immunogenetic Insights     Open Access   (Followers: 5)
Immunology and Infectious Diseases     Open Access   (Followers: 9)
Immunology Innovation     Open Access   (Followers: 2)
Immunology Letters     Hybrid Journal   (Followers: 13)
Immunology, Endocrine & Metabolic Agents - Medicinal Chemistry     Hybrid Journal   (Followers: 3)
Immunome Research     Open Access   (Followers: 6)
ImmunoTargets and Therapy     Open Access   (Followers: 2)
Immunotherapy     Hybrid Journal   (Followers: 7)
Immunotoxicology of Drugs and Chemicals: an Experimental and Clinical Approach     Full-text available via subscription   (Followers: 1)
Indian Journal of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Infectious Diseases: Research and Treatment     Open Access   (Followers: 4)
Inflammation & Allergy - Drug Targets     Hybrid Journal   (Followers: 2)
Inmunología     Full-text available via subscription   (Followers: 2)
Innate Immunity     Hybrid Journal   (Followers: 7)
International Archives of Allergy and Immunology     Full-text available via subscription   (Followers: 1)
International Forum of Allergy & Rhinology     Hybrid Journal   (Followers: 4)
International Immunology     Hybrid Journal   (Followers: 3)
International Immunopharmacology     Hybrid Journal   (Followers: 2)
International Journal of Immunological Studies     Hybrid Journal   (Followers: 1)
International Journal of Immunopathology and Pharmacology     Full-text available via subscription   (Followers: 2)
International Journal of Immunotherapy and Cancer Research     Open Access   (Followers: 1)
International Journal of Infectious Diseases     Open Access   (Followers: 10)
International Journal of Virology     Open Access   (Followers: 2)
International Reviews Of Immunology     Hybrid Journal   (Followers: 4)
Internet Journal of Rheumatology and Clinical Immunology     Open Access   (Followers: 5)
Iranian Journal of Allergy, Asthma and Immunology     Open Access  
Joint Commission Journal on Quality and Patient Safety     Hybrid Journal   (Followers: 40)
Journal des Anti-infectieux     Full-text available via subscription   (Followers: 2)
Journal of Allergy & Therapy     Open Access   (Followers: 2)
Journal of Clinical & Cellular Immunology     Open Access   (Followers: 3)
Journal of Vaccines & Vaccination     Open Access   (Followers: 4)
Journal of Allergy and Clinical Immunology     Hybrid Journal   (Followers: 31)
Journal of Allergy and Clinical Immunology : In Practice     Full-text available via subscription   (Followers: 13)
Journal of Asthma Allergy Educators     Hybrid Journal   (Followers: 4)
Journal of Asthma and Allergy     Open Access   (Followers: 8)
Journal of Autoimmunity     Hybrid Journal   (Followers: 15)
Journal of Cellular Immunotherapy     Open Access   (Followers: 4)
Journal of Clinical Immunology     Hybrid Journal   (Followers: 14)
Journal of Clinical Immunology and Immunopathology Research     Open Access   (Followers: 5)
Journal of General Virology     Full-text available via subscription   (Followers: 11)
Journal of Immune Based Therapies, Vaccines and Antimicrobials     Open Access   (Followers: 2)
Journal of Immunological Methods     Hybrid Journal   (Followers: 46)
Journal of Immunological Techniques in Infectious Diseases     Hybrid Journal   (Followers: 3)
Journal of Immunology     Full-text available via subscription   (Followers: 68)
Journal of Immunology and Clinical Microbiology     Open Access   (Followers: 2)
Journal of Immunology and Regenerative Medicine     Hybrid Journal   (Followers: 1)
Journal of Immunology Research     Open Access   (Followers: 9)
Journal of Immunotherapy     Hybrid Journal   (Followers: 7)
Journal of Immunotherapy Applications     Open Access  
Journal of Immunotoxicology     Open Access   (Followers: 3)
Journal of Infection Prevention     Hybrid Journal   (Followers: 16)
Journal of Infectious Diseases and Immunity     Open Access   (Followers: 8)
Journal of Innate Immunity     Open Access   (Followers: 6)
Journal of Medical Genetics and Genomics     Open Access   (Followers: 3)
Journal of Microbiology, Immunology and Infection     Open Access   (Followers: 9)
Journal of Neuroimmunology     Hybrid Journal   (Followers: 6)
Journal of NeuroVirology     Hybrid Journal   (Followers: 1)
Journal of Reproductive Immunology     Hybrid Journal   (Followers: 2)
Journal of the Pediatric Infectious Diseases Society     Hybrid Journal   (Followers: 11)
Journal of Translational Autoimmunity     Open Access   (Followers: 2)
Journal of Vaccines and Immunology     Open Access   (Followers: 1)
Medical Immunology     Open Access   (Followers: 20)
Medical Microbiology and Immunology     Hybrid Journal   (Followers: 7)
Microbiology and Immunology     Hybrid Journal   (Followers: 10)
Molecular Immunology     Hybrid Journal   (Followers: 17)
Mucosal Immunology     Hybrid Journal   (Followers: 6)
Nature Immunology     Full-text available via subscription   (Followers: 316)
Nature Reviews Immunology     Full-text available via subscription   (Followers: 301)
Neuroimmunology and Neuroinflammation     Open Access   (Followers: 3)
NeuroImmunoModulation     Full-text available via subscription   (Followers: 2)
Neurology : Neuroimmunology & Neuroinflammation     Open Access   (Followers: 4)
npj Vaccines     Hybrid Journal  
OA Immunology     Open Access  
Ocular Immunology & Inflammation     Hybrid Journal   (Followers: 9)
OncoImmunology     Full-text available via subscription   (Followers: 3)
Open Allergy Journal     Open Access  
Open Cancer Immunology Journal     Open Access  
Open Forum Infectious Diseases     Open Access   (Followers: 4)
Open Immunology Journal     Open Access  
Open Journal of Immunology     Open Access   (Followers: 5)
Open Virology Journal     Open Access  
Oral Microbiology and Immunology     Hybrid Journal   (Followers: 1)
Papillomavirus Research     Open Access  
Parasite Immunology     Hybrid Journal   (Followers: 3)
Pediatric Allergy and Immunology     Hybrid Journal   (Followers: 38)
Perspectives in Vaccinology     Open Access   (Followers: 1)
Photodermatology, Photoimmunology & Photomedicine     Hybrid Journal   (Followers: 3)
Polish Pneumonology and Allergology     Open Access   (Followers: 1)
Procedia in Vaccinology     Open Access   (Followers: 2)
Recent Patents on Inflammation & Allergy Drug Discovery     Hybrid Journal   (Followers: 2)
Research & Reviews : A Journal of Immunology     Full-text available via subscription   (Followers: 6)
Research Journal of Allergy     Open Access   (Followers: 3)
Research Journal of Immunology     Open Access   (Followers: 3)
Results in Immunology     Open Access   (Followers: 4)
Revista Alergia México     Open Access  
Revista Portuguesa de Imunoalergologia     Open Access   (Followers: 2)
Revue Française d'Allergologie     Full-text available via subscription   (Followers: 3)
Russian Journal of Infection and Immunity     Open Access   (Followers: 20)
Scandinavian Journal of Immunology     Hybrid Journal   (Followers: 10)
Science Immunology     Full-text available via subscription   (Followers: 17)
Self/Nonself - Immune Recognition and Signaling     Full-text available via subscription   (Followers: 2)
Seminars in Immunology     Hybrid Journal   (Followers: 13)
Seminars in Immunopathology     Hybrid Journal   (Followers: 3)
Signals     Open Access   (Followers: 1)
Sinusitis     Open Access   (Followers: 1)
South East European Journal of Immunology     Open Access  
Therapeutic Advances in Vaccines     Hybrid Journal   (Followers: 1)
Therapeutic Advances in Vaccines and Immunotherapy     Open Access  
Toxicology and Environmental Health Sciences     Hybrid Journal   (Followers: 6)

        1 2 | Last

Similar Journals
Journal Cover
Annals of Allergy, Asthma, and Immunology
Number of Followers: 0  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1534-4436
Published by Elsevier Homepage  [3204 journals]
  • Information for Authors
    • Citation: Annals of Allergy, Asthma & Immunology 122, 4 (2019)
      PubDate: 2019-04
      DOI: 10.1016/S1081-1206(19)30151-6
      Issue No: Vol. 122, No. 4 (2019)
  • Information for Readers
    • Citation: Annals of Allergy, Asthma & Immunology 122, 4 (2019)
      PubDate: 2019-04
      DOI: 10.1016/S1081-1206(19)30149-8
      Issue No: Vol. 122, No. 4 (2019)
  • Practicing allergy-immunology in the 21st century:
    • Authors: Gailen D. Marshall
      Pages: 353 - 354
      Abstract: All of us who are currently privileged to practice allergy-immunology in western medicine are often struck with the spectrum of technology available to us for diagnosis and management of diseases in the patients for whom we care. Our methods have become increasingly technically sophisticated as more sensitive testing and the introduction of newer and, in many cases, more effective therapies has become ever-increasingly available. As we all know, however, just because things are newer does not automatically make them better or even necessary to provide the optimal care we all seek to offer.
      Citation: Annals of Allergy, Asthma & Immunology 122, 4 (2019)
      PubDate: 2019-04
      DOI: 10.1016/j.anai.2019.02.017
      Issue No: Vol. 122, No. 4 (2019)
  • Author response
    • Authors: Tatjana Welzel; Victoria C. Ziesenitz, Stefanie Seitz, Birgit Donner, Johannes N. van den Anker
      Pages: 434 - 435
      Abstract: Thank you for your feedback regarding our article.1 The following are responses to your queries and comments.
      Citation: Annals of Allergy, Asthma & Immunology 122, 4 (2019)
      PubDate: 2019-04
      DOI: 10.1016/j.anai.2019.01.020
      Issue No: Vol. 122, No. 4 (2019)
  • Management of anaphylaxis and allergies in patients with long QT syndrome
    • Authors: John R. Cohn
      First page: 434
      Abstract: Thank you to you and your colleagues for your valuable and thoughtful paper, “Management of anaphylaxis and allergies in patients with long QT syndrome.”1 Because high-dose antihistamine therapy for chronic urticaria has become increasingly common, we have been considering what (if any) precautions should be taken before prescribing that to a patient, including such seemingly “routine” measures (not routine in an allergist's office), such as getting an electrocardiogram on anyone getting an antihistamine, which is surely a lot of patients.
      Citation: Annals of Allergy, Asthma & Immunology 122, 4 (2019)
      PubDate: 2019-04
      DOI: 10.1016/j.anai.2019.01.019
      Issue No: Vol. 122, No. 4 (2019)
  • Comparison of allergic rhinitis outcomes of the Environmental Exposure
           Unit and Nasal Allergen Challenge Model
    • Authors: Mark W. Tenn; Lisa M. Steacy, Daniel E. Adams, Terry J. Walker, Anne K. Ellis
      Abstract: Traditional field studies are one of the earliest study designs used to assess the clinical efficacy of allergic rhinitis (AR) medications.1 However, accurately attributing clinical improvement to new treatments using this design can be difficult due to confounding factors such as variable weather conditions and airborne allergen levels.1,2 Controlled allergen challenge facilities (CACFs) such as the Environmental Exposure Unit (EEU) and direct nasal allergen challenge (NAC) models were developed to provide allergen exposure under tightly controlled conditions.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-04-05
      DOI: 10.1016/j.anai.2019.04.003
  • The Development and Evaluation of Peer Food Allergy Education Videos for
           School- Age Youth
    • Authors: Jialing Jiang; Joel Gallagher, Jolanta Szkodon, Maaria Syed, Karina Gobin, Ruchi Gupta, Lucy Bilaver
      Abstract: Food allergy (FA) affects nearly 8% of children in the United States.1 Approximately 16-18% of children have experienced an allergic reaction at school,2,3 and 25% of first-time anaphylactic reactions occur at school.4 Children with FA feel that peer support decreases risk-taking and promotes safety.5 Peer education may be effective in improving FA knowledge among children, due to legitimized content by peers, whom children often trust over adults at this age.6 It may also improve the safety of children with FA.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-04-05
      DOI: 10.1016/j.anai.2019.04.002
  • Improving Allergy Skin Testing Proficiency
    • Authors: Rachna R. Dave; Catherine M. Hammond, Charles W. Stewart, D.Betty Lew
      Abstract: Skin prick/puncture testing (SPT) is currently considered the “gold standard” method for epicutaneous allergy testing. There are multiple advantages of SPT compared to in vitro testing. It is less expensive, less invasive, and provides faster, highly specific results, and a better correlation with inhalant allergy symptoms1. However, there are noted disadvantages to the SPT method, largely based on variability factors. These include controllable variables, such as patient medications (antihistamines, psychotropic agents, high dose oral corticosteroids, and immunotherapy), the device used for the SPT, and the technique and proficiency of the test administrator.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-04-05
      DOI: 10.1016/j.anai.2019.04.001
  • Anti-Eosinophil Therapy is associated with Decreased Body Mass Index in
           Severe Asthmatics: a Preliminary Retrospective Analysis
    • Authors: Merin Kuruvilla; Meera Patrawala, Joshua M. Levy, Jennifer Shih, Frances E. Lee
      Abstract: The type 2 high endotype of asthma with adult onset is often characterized by severe persistent, steroid refractory eosinophilic inflammation. Interleukin-5 (IL-5) is a pivotal cytokine for eosinophil survival. The amelioration of eosinophilic inflammation through anti-IL-5 therapies (mepolizumab, reslizumab, and benralizumab) has been demonstrated to reduce exacerbations and improve control, and overall well-tolerated.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-04-04
      DOI: 10.1016/j.anai.2019.03.031
  • Exploring Latent Classes to Identify Prenatal and Early-life Sources of
           Racial Disparities in Allergic Disease
    • Authors: Ganesa Wegienka; Alexandra Sitarik, Albert M. Levin, Edward M. Zoratti, Dennis Ownby, Christine Cole Johnson, Suzanne Havstad
      Abstract: We previously reported that racial differences in rates of allergic disease outcomes emerge as early as age 2 years, but could not explain the differences by examining a series of individual factors.(1, 2) Hypothesizing that racial differences are not entirely due to genetic factors, this challenge called for the application of an analytical approach that would simultaneously address the interrelatedness of the factors given power constraints. Latent class (LC) analysis uses underlying relationships between selected variables to group individuals.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-04-04
      DOI: 10.1016/j.anai.2019.03.030
  • Pediatricians underestimate parent receptiveness to early peanut
    • Authors: Michelle Lai; Scott H. Sicherer
      Abstract: Peanut allergy prevalence has increased.1 The Learning Early About Peanut (LEAP) study found early peanut introduction to high-risk infants reduced the risk of peanut allergy.2 In response, the National Institute of Allergy and Infectious Diseases (NIAID) convened an Expert Panel that published guidelines for early peanut introduction.3 There are potential barriers to guideline implementation. The recommendations are quite different from ones espoused 20 years ago.4 Further, peanut is not a common weaning food and the medicalization of peanut introduction could be problematic.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-04-03
      DOI: 10.1016/j.anai.2019.03.034
  • “Early Immunologic Changes During the Onset of Atopic
    • Authors: Patrick M. Brunner
      Abstract: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, characterized by a fluctuating course, intense itch, and strongly inflamed skin lesions,1 putatively caused by a complex interaction of genetic, immune and environmental factors.2 AD is a highly heritable disease, showing strong associations with filaggrin (FLG) gene null mutations and Th2 signaling pathways,2 that have implications for epithelial barrier and skin inflammatory properties in affected individuals, respectively.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-04-03
      DOI: 10.1016/j.anai.2019.03.033
  • Development Of A Progesterone-Specific IgE Assay For Diagnosing Patients
           With Suspected Progestogen Hypersensitivity
    • Authors: Debajyoti Ghosh; Jonathan Bernstein
      Abstract: Progestogen hypersensitivity (PH; a.k.a autoimmune progesterone dermatitis) was first reported 50 years ago in a woman whose symptoms correlated with the luteal phase of her menstrual cycle.1 Of note, her symptoms were partially resolved with estrogen administration. Since this case, PH cases manifesting as a spectrum of dermatologic eruptions in the presence or absence of anaphylactic symptoms have been reported. The classic presentation of PH symptoms is an onset beginning during the second half of the cycle when progesterone levels begin to increase.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-04-03
      DOI: 10.1016/j.anai.2019.03.032
  • Perception and practice of sublingual immunotherapy among practicing
           allergists in the United States: a follow-up survey.
    • Authors: Anita Sivam; Mike Tankersley, ACAAI Immunotherapy Diagnostics Committee
      Abstract: The use of subcutaneous immunotherapy (SCIT) is a well-established treatment modality for allergic rhinoconjunctivitis since it was initially described by Noon and Freeman in 1911.1 This is the only disease-modifying treatment available. Sublingual immunotherapy (SLIT) has been used in Europe for decades, but is gaining popularity in the United States, especially with the recent FDA-approval of several SLIT products. Current products include ORALAIR® (Stallergenes; Antony, France) which contains 5 northern grass pollens (Kentucky blue grass, orchard, perennial rye, sweet vernal, and Timothy), GRASTEK® (Merck; Whitehouse Station, NJ) which contains Timothy grass pollen, RAGWITEK® (Merck) which contains short ragweed, and ODACTRA® (ALK; Swindon, Wiltshire, UK) which contains house dust mite.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-04-01
      DOI: 10.1016/j.anai.2019.03.023
  • "What do allergists in practice need to know about non-IgE-mediated food
    • Authors: S. Mehr; Terri Brown-Whitehorn
      Abstract: Unlike IgE mediated food allergy (FA), where one pathophysiological mechanism explains one disease process, non-IgE FA encapsulates a number of disease states caused by different mechanisms (reviewed in1,2) but unified in their ability to cause gastrointestinal inflammation. The commonest non-IgE mediated disorders encountered and managed by allergists include food protein induced allergic proctocolitis (FPIAP), eosinophilic esophagitis (EoE), food protein induced enteropathy (FPE), and food protein induced enterocolitis syndrome (FPIES).
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-29
      DOI: 10.1016/j.anai.2019.03.025
  • Effect of topical pramoxine hydrochloride on discomfort, wheal and flare
           associated to epicutaneous allergy test
    • Authors: Erika Watts; Giannina Coppola Fasick, Erving Arroyo-Flores, Marievelisse Soto-Salgado, Sylvette Nazario
      Abstract: Prick-puncture test is the primary diagnostic modality for Immunoglobulin E (IgE) mediated hypersensitivity reactions1. Allergen extracts are applied to the skin with a prick-puncture device. Wheal and flare diameters are measured fifteen minutes after application and compared with positive (histamine) and negative (saline) controls2. Although this technique is very sensitive for the diagnosis of IgE mediated hypersensitivities, it is occasionally deferred because of concerns for discomfort, particularly among children.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-27
      DOI: 10.1016/j.anai.2019.03.029
  • The Emerging Biologic Therapies on Food Allergy
    • Authors: Sultan Albuhairi; Rima Rachid
      Abstract: Food allergy affects ∼8% of children and up to 5% of adults. Standard-of-care consists of food avoidance and keeping rescue epinephrine and antihistamines available.1 While oral (OIT) and/or epicutaneous immunotherapy (EPIT) products may receive FDA within the next 1-2 years, these require long-term compliance and are not known to lead a cure and may cause recurrent allergic reactions. A number of biologics has been used to treat atopic diseases and asthma but only few have been evaluated to date in food allergy (Table1).
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-27
      DOI: 10.1016/j.anai.2019.03.028
  • Prediction of acute asthma exacerbation severity and interrater
           reliability of manual pulsus paradoxus measurement
    • Authors: Donald H. Arnold; Adam A. Vukovic, Cosby G. Arnold, Cody Penrod, Jonas A. Pologe
      Abstract: Pulsus paradoxus (PP) represents an exaggeration of the normal fluctuation of left ventricular stroke volume and systolic blood pressure during the respiratory cycle.1 This physiologic phenomenon was first described by Lower in 1669 and the term pulsus paradoxus first applied by Kussmaul in 1873.2 PP measurement is recommended to identify or assess the severity of acute asthma exacerbations, tension pneumothorax, cardiac tamponade and other potentially life-threatening disorders.3
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-27
      DOI: 10.1016/j.anai.2019.03.027
  • Food Allergy, Eosinophilic Esophagitis and the Enigma of IgG4
    • Authors: Emily C. McGowan; Thomas A.E. Platts-Mills, Jeffrey M. Wilson
      Abstract: The recognition that IgE, formerly known as reagin, is central to the pathogenesis of allergic disease dates back nearly a century to the seminal work of Prausnitz and Kustner. By contrast, IgG4 represents an antibody subclass that is often increased in the setting of allergic disease but whose role in disease pathogenesis is less clear1. Reports in the 1980s suggested that allergen-specific IgG4 could play a role as an anaphylactic antibody, but subsequent research cast significant doubt on this possibility.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-27
      DOI: 10.1016/j.anai.2019.03.024
  • Gadolinium induced anaphylaxis with positive skin tests
    • Authors: Guillermo Rodriguez-Nava; Alex M. Kesler, Ismael Carrilo-Martin, Alexei Gonzalez-Estrada
      Abstract: Gadolinium is a heavy metal element with paramagnetic properties used as contrast in Magnetic Resonance Imaging (MRI) studies. There are nine types of gadolinium-based contrast agents (GBCAs), that may be classified as ionic or nonionic and linear or macrocyclic.1 Hypersensitivity reactions (HSR) to GBCAs are uncommon (0.004 to 0.7%), but anaphylaxis (0.001 to 0.01%2) and fatalities have occurred. These less frequent acute reactions were once considered non-immunological. However, there are few case reports implicating an IgE-dependent allergic mechanism.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-26
      DOI: 10.1016/j.anai.2019.03.022
  • Alpha-gal phenotypes- lessons from various patient populations
    • Authors: Michael Levin; Danijela Apostolovic, Tilo Biedermann, Scott P. Commins, Onyinye I. Iweala, Thomas A.E. Platts-Mills, Eleonora Savi, Marianne van Hage, Jeffrey M. Wilson
      Abstract: Galactose alpha-1,3-galactose (alpha-gal) is a carbohydrate epitope found on proteins and lipids in non-primate mammals and present in foods (particularly organ or fat-rich red meat) and medications, where it causes delayed onset and immediate onset anaphylaxis respectively. Several species of ticks contain alpha-gal epitopes and possibly salivary adjuvants that promote high titre sensitisation and clinical reactivity. Risk factors for alpha-gal syndrome include exposure to ticks of particular species.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-25
      DOI: 10.1016/j.anai.2019.03.021
  • Feeding Difficulties in Children with non-IgE mediated Food Allergic
           Gastrointestinal Disorders
    • Authors: Mirna Chehade; Rosan Meyer, Alexia Beauregard
      Abstract: Food allergies can involve the gastrointestinal (GI) tract in various ways. Immunoglobulin E (IgE)-mediated food allergies typically cause nausea and vomiting, which can occur almost immediately following ingestion of the culprit food, often while the food is still being consumed, and/or diarrhea, which may occur promptly or may be delayed by several hours.1 In contrast, non-IgE-mediated food allergic reactions are more delayed. They occur with repetitive exposure to the culprit food(s) and typically result in chronic inflammation affecting various parts of the gastrointestinal (GI) tract with associated symptoms (Table 1).
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-25
      DOI: 10.1016/j.anai.2019.03.020
  • The Prevalence of Atopic Dermatitis in Children with Food Allergy
    • Authors: Waheeda Samady; Christopher Warren, Simran Kohli, Rohan Jain, Lucy Bilaver, Anthony J. Mancini, Ruchi Gupta
      Abstract: Food allergy (FA) impacts approximately 8% of children in the U.S.1 The strongest and most established risk factor for the development of FA is atopic dermatitis (AD), a pruritic inflammatory skin disease that is most common in children.2 The HealthNuts cohort study found that one in five Australian infants with AD were allergic to peanut, egg white, or sesame compared to 1 in 25 infants without AD,2 indicating a strong link between AD and FA. A leading theory for how AD predisposes to the development of FA is referred to as the Dual Allergen Exposure Hypothesis, which proposes that allergic sensitization to food can occur through cutaneous exposure and the altered skin barrier in AD results in increased permeability to food allergens.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-25
      DOI: 10.1016/j.anai.2019.03.019
  • Efficacy and safety of olopatadine/mometasone combination nasal spray for
           the treatment of seasonal allergic rhinitis
    • Authors: Gary N. Gross; Gary Berman, Niran J. Amar, Cynthia F. Caracta, Sudeesh K. Tantry
      Abstract: Allergic rhinitis (AR) is a nasal inflammatory response caused by an exaggerated immunological reaction to an allergen that is generally characterized by one or more symptoms of nasal congestion, sneezing, rhinorrhea, and nasal itching.1 AR is one of the most common chronic diseases in both pediatric and adult patients, affecting 5.6 million children2 and 19.9 million adults in the US.3 While AR is typically categorized as perennial (PAR; occurring year-round) or seasonal (SAR; occurring in a specific pollen season), the distinction between these can be difficult to determine as some patients can have both SAR and PAR, and SAR can occur year-round in tropical or warm climates.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-22
      DOI: 10.1016/j.anai.2019.03.017
  • From the pages of AllergyWatch June 2019
    • Authors: Stanley M. Fineman; David A. Khan, John J. Oppenheimer
      Abstract: Childhood food allergies resolve over time in some patients, but little is known about the mechanisms by which food allergy develops or resolves. Recent evidence suggests that activation of the innate immune system in early life might play a causal role in predisposing to food allergy. This study examined innate immune profiles associated with the development of egg allergy and natural tolerance in childhood, including the effects of serum vitamin D. The study used peripheral blood mononuclear cell samples longitudinally collected from 54 infants enrolled in the population-based HealthNuts study: 36 who had egg allergy at age 1 year and 18 with no food allergy.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-22
      DOI: 10.1016/j.anai.2019.03.016
  • Life-long learning and the ABAI: practice improvement comes of age
    • Authors: Mitchell H. Grayson; John Oppenheimer, Mariana Castells, Anna Nowak-Wegrzyn
      Abstract: ANW receives grants from DBV Technologies, Astellas Pharma, Nutricia, and Nestle; receives royalties from UpToDate; serves on advisory boards for the Gerber Institute, Merck, ALK-Abello, Regeneron; and is the deputy editor for the Annals of Allergy Asthma and Immunology.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-22
      DOI: 10.1016/j.anai.2019.03.015
  • In Memoriam: Douglas C. Heiner, MD, PhD (1925-2018)
    • Authors: Sami L. Bahna
      Abstract: Dr. Douglas Cragun Heiner, 93, passed away peacefully of natural causes at home in Alpine, Utah on September 19, 2018. He graduated from the University of Pennsylvania School of Medicine with Honors in 1950. After a one-year internship, he began active duty at the U.S. Army Hospital in Aberdeen, Maryland then ordered to the Expeditionary U.S. Army Headquarters in Seoul, Korea, where he served for 15 months as a preventive medicine officer.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-22
      DOI: 10.1016/j.anai.2019.03.014
  • Caregiver perceptions of when to offer an oral food challenge for children
           with food allergy
    • Authors: Monica T. Kraft; Rebecca Scherzer, Elizabeth A. Erwin, Irene Mikhail
      Abstract: Food allergy (FA) is a rising public health concern, affecting up to 5% of the pediatric population.1 Oral food challenges (OFCs) are the gold standard for diagnosing FA.2 Although the decision to undergo an OFC is multifactorial, current guidelines suggest considering an OFC when the likelihood of passing the challenge is approximately 50%.3 Prior studies have shown that performing an OFC is associated with better quality of life (QOL) among caregivers of individuals with FA and reduced parental burden of FA, regardless of challenge outcome.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-22
      DOI: 10.1016/j.anai.2019.03.010
  • Sexual Intercourse as a Trigger of Inducible Urticaria
    • Authors: Mario Geller
      Abstract: Aerobic exercises can precipitate inducible urticarias. Cholinergic urticaria and exercise-induced anaphylaxis are good examples of these triggers1-2. The same can happen in patients with delayed pressure urticaria when areas of the body are compressed during exercises3. To our knowledge, sexual intercourse has not been documented for triggering inducible urticarias. We are presenting two cases of inducible urticaria precipitated by sexual intercourse: exercise-induced anaphylaxis and delayed pressure urticaria.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-20
      DOI: 10.1016/j.anai.2019.03.012
  • Association Between Fungal Spore Exposure in Inner-City Schools and Asthma
    • Authors: Sachin N. Baxi; William J. Sheehan, Joanne E. Sordillo, Michael L. Muilenberg, Christine A. Rogers, Jonathan M. Gaffin, Perdita Permaul, Peggy S. Lai, Margee Louisias, Carter R. Petty, Chunxia Fu, Diane R. Gold, Wanda Phipatanakul
      Abstract: Asthma is the most common chronic disease among children. Poorly controlled asthma can cause disturbed sleep, limited activity and missed school days. The environment is one of many factors that influence asthma morbidity1, 2. Several studies and meta-analyses have recognized that home fungus exposure may be associated with development or worsening of asthma3-9. Children spend a large portion of their day in school; however, few studies have provided a comprehensive assessment of fungus in the school classroom and the possible effects on students with asthma10-13.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-20
      DOI: 10.1016/j.anai.2019.03.011
  • Understanding Patient Experiences with Allergen Immunotherapy: “Living
           with Allergies Study”
    • Authors: Brian Stone; Ellyn Charap, Heather L. Black
      Abstract: For patients with allergic rhinoconjunctivitis (AR) who are considering allergen immunotherapy (AIT), uncertainty over treatment choice due to whether the treatment fits with one’s values and lifestyle may be common and problematic. Furthermore, a review of AIT adherence found that premature discontinuation occurred at rates ranging from 6% to 84% for subcutaneous immunotherapy (SCIT) and 21% to 93% for sublingual immunotherapy (SLIT).1 Although shared decision making (SDM) between physicians and patients has been shown to impact adherence in other therapeutic areas,2, 3 there is little insight into the role it may or may not play in patient decisions about AIT.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-20
      DOI: 10.1016/j.anai.2019.03.009
  • “Rituximab hypersensitivity and desensitization: A personalized approach
           to treat cancer and connective tissue diseases”
    • Authors: Barbara C. Yang; Mariana C. Castells
      Abstract: Rituximab is a chimeric monoclonal anti-CD20 antibody with wide use in cancer (lymphoma) and connective tissue diseases (rheumatoid arthritis, and vasculitis)1. Hypersensitivity reactions to rituximab can range from type I IgE-mediated reaction (urticaria, shortness of breath, hypotension, or anaphylaxis), to cytokine-mediated reaction (fevers, chills, rigors), or a mix of both, thus limiting the use of rituximab as first line therapy for many cases. Desensitization is a new therapeutic approach which can be performed with rituximab to offset these reactions.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-15
      DOI: 10.1016/j.anai.2019.03.008
  • Clinical standardization of two controlled allergen challenge facilities
           – The Environmental Exposure Unit and the Biogenics Research Chamber
    • Authors: Anne K. Ellis; Robert L. Jacobs, Mark W. Tenn, Lisa M. Steacy, Daniel E. Adams, Terry J. Walker, Alkis G. Togias, Daniel A. Ramirez, Charles P. Andrews, Cynthia M. Visness, Robert L. James, Cynthia G. Rather
      Abstract: To overcome the confounding factors present in natural exposure allergy studies, controlled allergen challenge facilities (CACFs) were developed to provide exposures under tightly regulated conditions.1 CACF engineering allows the creation of stable, controlled environments for studies in disparate geographical regions to mitigate the confounding factors of traditional natural exposure studies of varying aeroallergens, wind, rain, humidity, temperature and differences in the magnitude of pollen exposure between study participants due to individual exposures.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-13
      DOI: 10.1016/j.anai.2019.03.007
  • Venom Shortages: What’s an Allergist to do' Part 1, The Issues
    • Authors: J.Allen Meadows; David B.K. Golden, James Tracy, Erika Gonzalez Reyes, James Sublett
      Abstract: Venom immunotherapy (VIT) for the management of stinging insect allergy has been an important service provided by allergists for nearly four decades.1 Venom extracts are unique in a number of ways. Directly measured in micrograms compared to potency measures as used in other forms of immunotherapy, they were also the first standardized extracts used in clinical practice. In addition, they are the only approved treatment for the prevention of anaphylaxis. In 1978, the landmark work published by Hunt et al.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-13
      DOI: 10.1016/j.anai.2019.03.006
  • Challenges and safety of beta lactam desensitization during extracorporeal
           membrane oxygenation
    • Authors: Dinah Foer; Kathleen Marquis, Natasha Romero, Mariana C. Castells
      Abstract: Extracorporeal membrane oxygenation (ECMO) is an advanced life support therapy used in patients with refractory cardiac and/or respiratory failure. The growth of ECMO use internationally over the past decade has been exponential1 paralleling an increase in lung transplant volume4. Trends at our institution, an urban, tertiary academic medical center reflects this growth, approximately doubling in volume each year and paralleling the increase of transplants in CF patients. ECMO has been used as a temporizing measure for progressive respiratory failure in patients with cystic fibrosis (CF) as a bridge to lung transplant2.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-13
      DOI: 10.1016/j.anai.2019.03.005
  • Delayed and Protracted Allergic Reaction to Oral Lidocaine
    • Authors: Sanan Neha; Lee Jenny, Baxter Christina, Jeskey Jack, Hostoffer Robert
      Abstract: Lidocaine is widely used in the peri-procedural setting for pain control. Local anesthetics (LA) are generally well tolerated, and allergic reactions reported are less than 1 % (1). Symptoms range from skin erythema, urticaria to anaphylactic shock (2-4). There have been no reported cases of allergic reactions to oral viscous lidocaine. We present the first case of a delayed, protracted allergic reaction to oral viscous lidocaine with positive intradermal testing.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-13
      DOI: 10.1016/j.anai.2019.03.004
  • Evaluating Penicillin Allergies in Children Using a Standard EMR-based
    • Authors: Cathleen A. Collins; David Choe, Dylan Mochizuki, Christopher R. Cannavino
      Abstract: A 2016 AAAAI position statement recommended routine evaluation of penicillin allergies due to the burden of pervasive mislabeled or outgrown allergies.1 Overdiagnosis of penicillin allergies is an increasingly recognized public health problem, resulting in longer hospitalizations, use of costly antibiotics with potential harmful side effects and infection with resistant organisms.2 The scale of the problem is daunting; for example, at Rady Children’s Hospital San Diego (RCHSD), with 1.4 million children in its EMR, there are more than 40,000 (2.8%) children labeled with penicillin allergies.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-13
      DOI: 10.1016/j.anai.2019.03.002
  • Venom Shortages: What’s an Allergist to do' Part Two: Potential
    • Authors: J.Allen Meadows; David B.K. Golden, James Tracy, Erika Gonzalez Reyes, James Sublett
      Abstract: The surprise announcement in March 2018 that ALK was leaving the North American venom market permanently changed the landscape for venom immunotherapy. The American College of Allergy Asthma and Immunology (College) and the American Academy of Allergy Asthma and Immunology (Academy) have jointly communicated with Jubilant HollisterStier (JHS) about long-term product and supply issues. Even with reassurances of price and supply stability given to the two national allergy organizations by the remaining venom vendor, the Advocacy Council of the American College of Allergy, Asthma and Immunology continued to receive calls and emails expressing concerns about pricing and availability of venom extracts.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-13
      DOI: 10.1016/j.anai.2019.03.001
  • Asthma and Academic Performance in Urban Children
    • Authors: Daphne Koinis-Mitchell; Sheryl J. Kopel, Michael L. Farrow, Elizabeth L. McQuaid, Jack H. Nassau
      Abstract: Urban minority children are at increased risk for asthma morbidity.1 Factors related to urban living, such as exposure to urban stressors violence, neighborhood stress,2,3,4 environmental irritants and allergens,5 poorer medication adherence,6 and cultural factors related to ethnic background (e.g., acculturative stress, discrimination),7 place this group at greater risk for poorer asthma control and morbidity. When asthma is poorly controlled, children are at greater risk for decrements in other areas of functioning, such as academic performance.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-11
      DOI: 10.1016/j.anai.2019.02.030
  • Diverse age-incidence patterns of atopic sensitisation in an unselected
           Finnish population up to 12 years
    • Authors: Kaisa Pyrhönen; Petri Kulmala, Simo Näyhä, Esa Läärä
      Abstract: The clinically observed progression of atopic diseases is often described in terms of an ‘atopic march’; from atopic eczema to respiratory allergies (allergic rhinitis and/or asthma)1-5. The incidence of atopic manifestations has previously been defined by using the first date of hospital admission for these conditions or dispensed prescription of specific medication6 or by the age at diagnoses of atopic manifestations7.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-07
      DOI: 10.1016/j.anai.2019.02.027
  • Childhood asthma from a health equity perspective: The case of Latin
           America and the Caribbean
    • Authors: Arachu Castro
      Abstract: Asthma is the most frequent chronic non-communicable disease of childhood in the world1 and is particularly prevalent in urban settlements, where traffic-related pollution and 3 household dampness—particularly common in slums—can lead to oxidative stress and airway
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-06
      DOI: 10.1016/j.anai.2019.02.029
  • Experience in patch testing: A 6-year retrospective review from a single
           academic allergy practice
    • Authors: Britta K. Sundquist; Barbara Yang, M. Ashgar Pasha
      Abstract: Contact dermatitis is an inflammatory cutaneous reaction induced by an exogenous agent coming into direct contact with the skin and is characterized by pruritic, well-defined, eczematous dermatitis with vesicles, or erythematous papules.[1-3] Irritant contact dermatitis (ICD) accounts for >80% of cases and occurs as a result of direct damage to the skin by physical agents or chemicals without prior sensitization.[4] Only 20% of cases of contact dermatitis have an underlying allergic mechanism. Allergic contact dermatitis (ACD) is a delayed, type IV (T-cell mediated) hypersensitivity reaction occurring in susceptible individuals with prior sensitization.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-06
      DOI: 10.1016/j.anai.2019.02.028
  • Asthma, Copd And Home Environments: Interventions With Older Adults
    • Authors: David A. Turcotte; Susan Woskie, Rebecca Gore, Emily Chaves, Kelechi L. Adejumo
      Abstract: The World Health Organization estimates that at least 300 million people suffer from asthma worldwide.1 Over 17.7 million adults suffer from asthma compared to the 6.3 million children who are also afflicted with asthma in the United States (U.S.).2 Older adults ages 65 and over with asthma are the fastest growing age-group in the U.S.3 Studies in the United States show that asthma and other reactive airway diseases are under-diagnosed among the elderly, that asthma-related morbidity and mortality among the elderly is increasing4 and that nationally the number of older adults dying from asthma is 14 times higher compared to those 18-35 years of age.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-01
      DOI: 10.1016/j.anai.2019.02.026
  • Airway Hyperresponsiveness in young Children with Respiratory Symptoms: A
           Five-Year Follow-Up
    • Authors: Satu Kalliola; L. Pekka Malmberg, Kristiina Malmström, Anna Pelkonen, Mika J. Mäkelä
      Abstract: Lower respiratory symptoms with wheeze are common in early childhood (1). Most young children cease to wheeze before school age (2), but some early childhood risk factors may determine the lifelong respiratory outcome. Clinical characteristics associated with persistent wheeze include maternal smoking, parental asthma, severity of wheezing, atopy and elevated IgE (3,4). Increased airway hyperresponsiveness (AHR) in infancy has also been connected to persistent symptoms later in life (5-7).
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-01
      DOI: 10.1016/j.anai.2019.02.025
  • Small airway dysfunction may be an indicator of early asthma: findings
           from high-resolution CT
    • Authors: Dan Jiang; Zhimin Wang, Cong Shen, Chenwang Jin, Nan Yu, Jun Wang, Nan Yin, Youmin Guo
      Abstract: Asthma is a common chronic respiratory disease that affects approximately 300 million individuals worldwide and brings a major health care burden 1. Chronic airway inflammation and characteristic structural changes, often described as “airway remodeling”, are observed in the airways of patients with asthma. Evidence from surgically resected lung tissue, autopsy lung specimens, and transbronchial biopsies suggests that airway inflammation and structural changes (subepithelial fibrosis, increased airway smooth muscle, increased blood vessels in the walls of the airways, and mucus hypersecretion) occurs in both the central and peripheral airways 2-9.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-01
      DOI: 10.1016/j.anai.2019.02.024
  • Subcutaneous immunotherapy in patients with eosinophilic esophagitis
    • Authors: Benjamin S. Robey; Swathi Eluri, Craig C. Reed, Maya R. Jerath, Michelle L. Hernandez, Scott P. Commins, Evan S. Dellon
      Abstract: Dr. Dellon is a consultant for Adare, Alivio, Allakos, Banner, Calypso, Enumeral, EsoCap, GSK, Gossamer Bio, Receptos/Celegene, Regeneron, Robarts, and Shire, receives research funding from Allakos, Adare, GSK, Meritage, Miraca, Nutricia, Receptos/Celgene, Regeneron, and Shire, and has received an educational grant from Allakos, Banner, and Holoclara. None of the other authors report and potential conflicts of interest with this study.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-01
      DOI: 10.1016/j.anai.2019.02.022
  • An institutional review of flying hymenoptera venom immunotherapy in
           patients with cutaneous systemic reactions only.
    • Authors: Priya Nath; Christopher Coop
      Abstract: The basis of venom immunotherapy (VIT) can be defined as protection against IgE-mediated immunologic mechanisms such as anaphylaxis.1,2 Most insect stings produce local reactions of swelling, pain, erythema and pruritus, typically peaking by 24-48 hours and resolving within 3-10 days.5 Unfortunately, some patients experience systemic reactions ranging from cutaneous reactions only (characterized by urticaria and/or angioedema, excluding throat, larynx and tongue) to life-threatening systemic anaphylactic reactions (SAR).
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-01
      DOI: 10.1016/j.anai.2019.02.020
  • Chronic spontaneous urticaria and angioedema requiring treatment with
           omalizumab in a patient with hereditary angioedema
    • Authors: Susan Tadros; Grant R. Hayman
      Abstract: A 27-year-old female patient with a history of hereditary angioedema (HAE), diagnosed at the age of 15 years, is routinely followed-up in Immunology clinic. She initially presented with a 3-year history of recurrent angioedema of the extremities and episodic acute abdominal pain with nausea and vomiting. Although there was no clear family history of HAE, she noted that her father had experienced swelling of the hand years before but had not sought medical attention for this. Both parents were advised to have C1 esterase inhibitor level and function tested however, have not yet done so.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-01
      DOI: 10.1016/j.anai.2019.02.019
  • Imported Fire Ant Hypersensitivity and Mastocytosis: A Case Series of
           Successful Venom Immunotherapy
    • Authors: Priya Nath; Karla Adams, Rebecca Schapira, Kathryn Edwards
      Abstract: The prevalence of flying hymenoptera venom hypersensitivity in patients with mast cell activation disorders (MCAD) is approximately 25% versus 2% in the general population.1 Previous studies have reported success with venom immunotherapy (VIT) for flying hymenoptera hypersensitivity in the setting of MCAD.2 To date, there are no cases of hypersensitivity to the imported fire ant (IFA), Solenopsis invicta/Solenopsis richteri specifically, in patients with MCAD in the literature. Moreover, this case series is the first to describe patients with MCAD and documented IFA hypersensitivity who have successfully completed the build-up phase of IFA-whole body extract (WBE) immunotherapy using conventional and rush protocols.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-03-01
      DOI: 10.1016/j.anai.2019.02.018
  • Rapid Onset of Effect of Benralizumab on Morning Peak Expiratory Flow in
           Severe, Uncontrolled Asthma
    • Authors: Geoffrey Chupp; Njira L. Lugogo, Joel N. Kline, Gary T. Ferguson, Ian Hirsch, Mitchell Goldman, James G. Zangrilli, Frank Trudo
      Abstract: Benralizumab (Fasenra™) is an interleukin (IL)-5 receptor alpha–directed cytolytic monoclonal antibody that induces direct, rapid, and nearly complete depletion of eosinophils in the circulation.1 Benralizumab is approved for use in Canada, Europe, Japan, and the United States.2–5 In the United States, it is indicated for the add-on maintenance treatment of patients with severe asthma aged 12 years and older with an eosinophilic phenotype.2 In the SIROCCO (NCT01928771) and CALIMA (NCT01914757) Phase III clinical trials, benralizumab treatment significantly reduced asthma exacerbations, increased lung function, and improved asthma symptoms in patients with severe, uncontrolled asthma and baseline blood eosinophil counts ≥300 cells/μL.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-23
      DOI: 10.1016/j.anai.2019.02.016
  • Cockroach, Dust Mite, and Shrimp Sensitization Correlations in The
           National Health and Nutrition Examination Survey
    • Authors: Emily C. McGowan; Roger Peng, Päivi M. Salo, Darryl C. Zeldin, Corinne A. Keet
      Abstract: Shellfish allergy is a common condition, affecting 1-2% of the U.S. population.1 Tropomyosin, the primary allergen in shrimp, is a muscle protein found in other arthropods, including cockroaches and dust mites (DM), and cross-sensitization to these allergens has been hypothesized to drive shrimp sensitization.2,3 In the National Health and Nutrition Examination Survey (NHANES), it was recently demonstrated that there was a marked decrease in the prevalence of shrimp sensitization between NHANES III (1988-1994) and NHANES 2005-2006.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-22
      DOI: 10.1016/j.anai.2019.02.015
  • Perspective Pro Debate: To introduce solids early or not to introduce,
           this is the question.
    • Authors: Helen R. Fisher; Gideon Lack, George Du Toit
      Abstract: Early life nutrition has the potential to influence long-term health; what an infant consumes and when they consume it is an important and potentially contentious topic. Breast milk alone will not sustain adequate infant growth beyond 6 months of age, solid food introduction is therefore essential to ensure normal growth through childhood. In the following pro debate, we discuss the evidence for solid food introduction commencing early in an infant’s life. The ages we refer to throughout reflect the ages of babies born at full term as prematurity was an exclusion criterion for most studies investigating timings of solid food introduction.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-22
      DOI: 10.1016/j.anai.2019.02.014
  • Utilization of high-fidelity simulation for medical student and resident
           education of allergic-immunologic emergencies
    • Authors: Stephanie L. Mawhirt; Luz Fonacier, Marcella Aquino
      Abstract: The advantages of clinical simulation used in medical education include the acquisition of clinical skills in a controlled setting, promoting a multidisciplinary approach to patient care, and a high degree of learner satisfaction.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-22
      DOI: 10.1016/j.anai.2019.02.013
  • Retrospective review of insurance coverage for patch testing
    • Authors: Azam A. Qureshi; Olabola Awosika, Kamaria Nelson, Spencer Brodsky, Haijun Wang, Alison Ehrlich
      Abstract: To characterize the burden of insurance limitations and its impact on differences in management and execution of patch testing.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-22
      DOI: 10.1016/j.anai.2019.02.012
  • An update on the controversy around offering oral immunotherapy to
           peanut-allergic children outside of research
    • Authors: Lianne Soller; Elissa M. Abrams, Edmond S. Chan
      Abstract: Oral immunotherapy (OIT) has emerged as an exciting treatment with the potential to help food-allergic children tolerate a food they have previously been told to avoid, sometimes for years, and often with substantial emotional and financial costs. However, an abundance of controversy surrounds OIT. This article reviews safety and efficacy, explores arguments in favor of and against use of OIT outside of research, and addresses the role of licensed products for OIT.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-20
      DOI: 10.1016/j.anai.2019.02.011
  • Point-of-care ultrasonography in the allergy and immunology clinic
    • Authors: Samira Jeimy; Andrew Wong-Pack, Shafaz Veettil, Harold Kim
      Abstract: To summarize evidence supporting the use of point-of-care ultrasonography as a clinical tool for allergists and immunologists.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-15
      DOI: 10.1016/j.anai.2019.02.010
  • African American ancestry contribution to asthma and atopic dermatitis
    • Authors: Michelle Daya; Kathleen C. Barnes
      Abstract: Asthma and atopic dermatitis (AD) are complex diseases with striking disparities across racial and ethnic groups, which may be partly attributable to genetic factors. Here we summarize current knowledge from asthma and AD genome-wide association studies (GWAS) and pharmacogenetic studies in African ancestry populations.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-14
      DOI: 10.1016/j.anai.2019.02.009
  • From the pages of AllergyWatch May 2019
    • Authors: Stanley M. Fineman; David A. Khan, Chitra Dinakar
      Abstract: Head and Neck, MOC:
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-14
      DOI: 10.1016/j.anai.2019.02.008
  • Drug Hypersensitivity Reactions in the Americas: Similarities and
    • Authors: Pedro Giavina-Bianchi; Edgardo Jares, Marcelo Vivolo Aun, Bernard Thong
      Abstract: Drugs are the most frequent cause of fatal anaphylaxis worldwide(1). The prevalence of adverse drug reactions (ADRs), including allergy, is known to be related to drug exposure frequency, gender, age, ethnicity and genetic factors, and it varies according to the classes of drugs, definitions of hypersensitivity reactions (HRs) and study design. Drug usage patterns vary significantly with time and geography, both across large countries and around the world(1-3).
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-14
      DOI: 10.1016/j.anai.2019.02.007
  • Drug-induced enterocolitis syndrome (DIES)
    • Authors: Anders O.J. Van Thuijl; Lonneke J. Landzaat, Olivia Liem, Joyce A.M. Emons, Nicolette J.T. Arends
      Abstract: Drug-induced enterocolitis syndrome (DIES) is a rare, non–IgE-mediated hypersensitivity reaction provoked by drugs that can be severe and lead to shock. Despite the potential severity of the reactions, awareness of DIES is low. In contrast, enterocolitis syndrome induced by food proteins (FPIES) has been better documented. Previous studies have reported the occurrence of hypovolemic shock in approximately 15% of reactions, which indicates that FPIES is a potentially life-threating disease.1 To increase clinical awareness of DIES, we report a case of a child who was referred to our pediatric allergy clinic and was diagnosed with DIES by amoxicillin.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-14
      DOI: 10.1016/j.anai.2019.02.004
  • Does angioedema influence the quality of life in chronic spontaneous
           urticaria patients'
    • Authors: A. Oles-Krykowska; K. Badura-Brzoza, Z. Brzoza
      Abstract: Chronic spontaneous urticaria (CSU) symptoms are wheals in a number of cases accompanied by recurrent angioedema. The proportion of CSU patients manifesting both wheals and angioedema and those reporting only one type of symptoms is different - a similar number of patients experience both symptoms or wheals only, whereas 1–13% experience angioedema only1,2. Symptoms of CSU have a detrimental influence on patients’ quality of life. Additionally, the coexistence between angioedema symptoms and wheals is related to prolonged disease duration2.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-12
      DOI: 10.1016/j.anai.2019.01.023
  • Eliminating health disparities in asthma
    • Authors: Christian Rosas-Salazar; Juan C. Celedón
      Abstract: Health equity, defined as “the attainment of the highest level of health for all people,”1 continues to be a fundamental but difficult-to-achieve goal in the United States, where some racial and ethnic minority groups are disproportionately affected by respiratory diseases, such as asthma. Indeed, the prevalence of asthma is higher in Puerto Ricans (14.3%) and African Americans (11.6%) than in non-Hispanic whites (8.3%) or Mexican Americans (5.7%).2 Moreover, Puerto Ricans and African Americans have higher morbidity and mortality from asthma than non-Hispanic whites.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-08
      DOI: 10.1016/j.anai.2019.02.001
  • Asthma status and risks among lesbian, gay, and bisexual adults in the
           United States
    • Authors: Cindy B. Veldhuis; Jean-Marie Bruzzese, Tonda L. Hughes, Maureen George
      Abstract: Asthma is uncontrolled in up to 71% of adolescents and adults,1 resulting in higher health care costs, more school and work absences, and higher mortality.1,2 Sexual minority (SM) adults (eg, people who identify as lesbian, gay, or bisexual or who have same-sex partners) have higher rates of asthma than their heterosexual counterparts.3,4 However, it is unclear whether rates and risk factors differ by sexual identity subgroups (eg, bisexual, men, lesbian). To address this critical knowledge gap, we conducted a scoping review to systematically search relevant literature following current guidelines.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-02
      DOI: 10.1016/j.anai.2019.01.021
  • Chronic itch management: therapies beyond those targeting the immune
    • Authors: Emilie Fowler; Gil Yosipovitch
      Abstract: Chronic itch can be a debilitating, unrelenting symptom. Over the years, we have advanced our knowledge about immune-mediated itch (eg, atopic dermatitis) and have developed several treatments targeting these immune pathways. Chronic itch that is noninflammatory in nature is more elusive. However, we have gained some understanding of the neural component mediating itch and have made progress in treating this challenging symptom.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-24
      DOI: 10.1016/j.anai.2019.01.016
  • Cost-effectiveness and comparative effectiveness of biologic therapy for
    • Authors: William C. Anderson; Stanley J. Szefler
      First page: 367
      Abstract: To evaluate relevant studies and documents that address the cost-effectiveness and comparative effectiveness of biologics current approved by the US Food and Drug Administration for the treatment of asthma.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-28
      DOI: 10.1016/j.anai.2019.01.018
  • Economic burden of food allergy- A systematic review
    • Authors: Lucy A. Bilaver; Priyam Doshi, Avneet S. Chadha, Linda O’Dweyer, Ruchi S. Gupta
      First page: 373
      Abstract: Food allergy (FA) is a life-threatening condition that is a growing health concern worldwide. Currently in the United States, 8% of children have a parent-reported FA.1 Much of the epidemiological work on FA has focused primarily on children; however, recent estimates have found that 10.8% of adults in the US have a self-reported FA.2 Furthermore, numerous studies have estimated the prevalence of FA in children from countries across Europe including France (6.7%),3 Greece (5.2%),4 and Sweden (6.8%).
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-28
      DOI: 10.1016/j.anai.2019.01.014
  • Characteristics of Inner City Children with Life-Threatening Asthma
    • Authors: Mary Elizabeth Bollinger; Arlene Butz, Mona Tsoukleris, Cassia Lewis-Land, Shawna Mudd, Tricia Morphew
      First page: 381
      Abstract: Poor children living in US inner cities have high prevalence of asthma as well as asthma related morbidity and mortality.(1-3) In 2013, there were 3,640 deaths due to asthma in the US; a rate of 1.1 deaths per 100,000 population.(4) Between 2007-2009, the death rate for African Americans aged 0–14 years was almost eight times greater than for whites in that age group(3). Several risk factors have been identified for fatal and near fatal asthma including a prior asthma admission to an intensive care unit (ICU), overuse of short acting beta agonists, underutilization of controller medication, poor recognition of asthma severity, psychosocial factors and multiple allergen sensitivity(5-8).
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-08
      DOI: 10.1016/j.anai.2019.02.002
  • The efficacy of 0.1% tacrolimus ophthalmic suspension in the treatment of
           severe atopic keratoconjunctivitis
    • Authors: Hiroyuki Yazu; Eisuke Shimizu, Naohiko Aketa, Murat Dogru, Naoko Okada, Kazumi Fukagawa, Hiroshi Fujishima
      First page: 387
      Abstract: Severe atopic keratoconjunctivitis (AKC) is a relatively rare disease, and some cases are refractory to conventional steroid treatment.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-10
      DOI: 10.1016/j.anai.2019.01.004
  • IgE testing can predict food allergy status in patients with moderate to
           severe atopic dermatitis
    • Authors: Pamela A. Frischmeyer-Guerrerio; Marjohn Rasooly, Wenjuan Gu, Samara Levin, Rekha D. Jhamnani, Joshua D. Milner, Kelly Stone, Anthony L. Guerrerio, Joseph Jones, Magnus P. Borres, Erica Brittain
      First page: 393
      Abstract: Diagnosing food allergy in patients with atopic dermatitis (AD) is complicated by their high rate of asymptomatic sensitization to foods, which can lead to misdiagnosis and unnecessary food avoidance.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-09
      DOI: 10.1016/j.anai.2019.01.001
  • Trends in hospitalizations related to anaphylaxis, angioedema and
           urticaria in the United States
    • Authors: Pragya Shrestha; Rashmi Dhital, Dilli Poudel, Anthony Donato, Paras Karmacharya, Timothy Craig
      First page: 401
      Abstract: Allergic disorders are a common clinical disorders with high rates of health care usage.1 Studies from developed countries have suggested an increasing prevalence of allergic diseases. 2–4 However, the data on the epidemiology of anaphylaxis, angioedema and urticaria are limited, with only small cohort studies available. 1,4 Recent studies from the United Kingdom (UK) and Australia have noted marked increase in hospitalizations related to urticaria, angioedema and anaphylaxis.1,4 Epidemiological study and incidence data of these conditions, however, depend on several factors, including diagnostic criteria used, variation in patient surveys, disease incidence in the general population and also diagnostic awareness among physicians.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-12
      DOI: 10.1016/j.anai.2019.02.003
  • Emerging Triggers of FPIES: Lessons from a Pediatric Cohort of 74 Children
           in the US
    • Authors: Andrea C. Blackman; Sara Anvari, Carla M. Davis, Aikaterini Anagnostou
      First page: 407
      Abstract: Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE mediated gastrointestinal food-induced allergic disorder occurring predominantly in infants and young children. Common food triggers and the natural history of FPIES vary according to geographic location. It is a serious condition that is still under-recognized, resulting in a delay in diagnosis and appropriate management. FPIES is characterized by delayed onset of repetitive vomiting occurring approximately 1 to 4 hours after food ingestion.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-02-08
      DOI: 10.1016/j.anai.2019.01.022
  • Pattern of medication use in children with very poorly controlled asthma
    • Authors: Arlene M. Butz; Tricia Morphew, Melissa Bellin, Mary Elizabeth Bollinger, Mona Tsoukleris
      First page: 412
      Abstract: Among the 8 million US children with asthma, approximately 50% experience an acute exacerbation each year.1 Recurrent emergency department visits and hospital admissions often result from poorly controlled asthma. National and international guidelines advise that the goal of asthma management is to achieve well-controlled asthma,2,3 yet asthma remains not well or very poorly controlled in approximately 50% of adult and pediatric patients.4 Achieving well-controlled asthma requires adept use of stepwise therapy and sufficient practitioner time for patient counseling to implement step-up and step-down therapy.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-24
      DOI: 10.1016/j.anai.2019.01.017
  • Evaluation of tryptase after subcutaneous immunotherapy–associated
           systemic reactions
    • Authors: Sofia Szari; Priscilla H. Wong, Howard C. Crisp, Edward Champoux, Tonya S. Rans, Christopher A. Coop
      First page: 413
      Abstract: Tryptase is an objective marker of mast cell burden and degranulation that is often released in conjunction with other mediators during anaphylaxis, resulting in transient elevation.1,2 In addition to elevations in absolute total tryptase levels, a few alternate definitions of tryptase levels elevations have been proposed, including an increase of 135%,3 a peak (SD) peak serum tryptase level of more than 2 + 1.2 times the baseline tryptase level,4 and more recently a reaction to baseline ratio of greater than 2.99.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-23
      DOI: 10.1016/j.anai.2019.01.013
  • Ethanol lock and immunoglobulin load
    • Authors: Catherine A. Popadiuk; Diana R. Lindsey, Milissa U. Jones, Cecilia P. Mikita
      First page: 415
      Abstract: A 3-year-old girl with trichohepatoenteric syndrome (THE-S) was admitted for an Escherichia coli central catheter–associated bloodstream infection. Her medical history includes chronic diarrhea (baseline of 4-5 loose stools per day) with total parenteral nutrition (TPN) via central catheter, failure to thrive (FTT), renovascular hypertension, iron deficiency anemia, liver impairment, multiple catheter infections, and pneumonia. She was born via cesarean section at an estimated gestational age of 35 weeks because of intrauterine growth restriction.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-23
      DOI: 10.1016/j.anai.2019.01.012
  • Disparities persist in asthma-related emergency department visits among
           Chicago children
    • Authors: Anna Volerman; Kristin Kan, Erica Salem, Nik Prachand, Chris M. Warren, Dominique Sighoko, Ruchi S. Gupta
      First page: 417
      Abstract: Disparities in pediatric asthma are well described, with prevalence and morbidity more than 2 times higher among Hispanic and black children as compared with white peers.1 Increased national attention has been focused on racial/ethnic disparities in asthma, with the goal of improving access and quality of care while reducing morbidity, such as emergency department (ED) visits.2 This study examines trends in asthma-related ED visits among Chicago children since 2009, with a particular focus on assessing racial and ethnic disparities, which previous work indicates may be substantial.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-23
      DOI: 10.1016/j.anai.2019.01.011
  • New IgE immediate hypersensitivity reactions on reintroduction of food
           restricted for treatment of eosinophilic esophagitis
    • Authors: Steven J. Gottlieb; Jonathan E. Markowitz, Evan S. Dellon
      First page: 419
      Abstract: Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease. Because EoE is largely food driven, elimination diet (ED) is 1 of the 2 primary modalities used to treat EoE1,2 Options include empiric EDs (6, 4, or 2 food EDs) or targeted EDs based on food allergy testing.3,4 Recently, children with EoE have been reported to develop immediate hypersensitivity reactions with reintroduction of previously immunoglobulin E (IgE) tolerated milk.5–8 Herein, anaphylaxis to previously tolerated wheat in an adult with EoE, and diffuse urticaria from soy reintroduction in a teen with EoE are presented.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-23
      DOI: 10.1016/j.anai.2019.01.010
  • A peripheral cause of asthma
    • Authors: Richard P. Ramonell; Merin Kuruvilla, Gabriel Sica, Remzi Bag, F. Eun-Hyung Lee
      First page: 420
      Abstract: Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is an aggressive subtype of T-cell non-Hodgkin's lymphoma. Despite the poor prognosis associated with PTCL, NOS, prompt diagnosis and treatment are critical to prevent further morbidity and mortality.1 We report a case of new-onset asthma with peripheral eosinophilia, subsequently diagnosed with PTCL, highlighting the need to consider a broad differential in the setting of uncontrolled atypical respiratory symptoms.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-23
      DOI: 10.1016/j.anai.2019.01.009
  • Oral challenge outcomes in children with adverse aminopenicillin
    • Authors: Alysa G. Ellis; Gordon R. Bloomberg
      First page: 422
      Abstract: Aminopenicillins, including ampicillin, amoxicillin, and amoxicillin-clavulanate, commonly cause dermatologic symptoms in children, who become diagnosed as being penicillin allergic. Without further investigation, children are prevented from receiving penicillin antibiotics when indicated as first-line therapy.1,2 There is a need to confirm or negate this diagnosis during childhood, but referral for penicillin testing is frequently deferred. Pediatricians and parents may not be aware of the clinical efficacy of penicillin testing, the effect of this misdiagnosis on future need, and, in young children, concern for the intrusiveness and pain of skin test procedure.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-11
      DOI: 10.1016/j.anai.2019.01.008
  • Concomitant hypersensitivity pneumonitis and occupational asthma caused by
           2 different etiologic agents
    • Authors: Elena Solana; Maria-Jesus Cruz, Christian Romero-Mesones, Xavier Muñoz
      First page: 424
      Abstract: Bronchial asthma is a chronic respiratory disease caused by an inflammatory response of the airway that causes bronchial hyperresponsiveness and variable obstruction to airflow, which is usually reversible.1 Hypersensitivity pneumonitis (HP) occurs as a consequence of an inflammatory response that damages the bronchoalveolar tissue and the pulmonary interstitium.2 Environmental factors are usually involved in the development of both entities; however, in each disease, different immunologic pathways have been implicated.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-11
      DOI: 10.1016/j.anai.2019.01.007
  • Another look at cyclosporine for treating antihistamine-resistant chronic
           spontaneous urticaria
    • Authors: Miles Weinberger
      First page: 425
      Abstract: There are only two treatments with demonstrated efficacy in randomized placebo controlled clinical trials for antihistamine-resistant chronic spontaneous urticaria (CSU), cyclosporine1 and omalizumab.2 The latter is a commercial product that was well studied to obtain FDA approval for marketing as a treatment for CSU within the past 5 years. Cyclosporine is a generic drug that was first demonstrated in a randomized placebo controlled trial to be an effective treatment for CSU almost 20 years ago.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-11
      DOI: 10.1016/j.anai.2019.01.006
  • Anaphylaxis to amoxicillin-clavulanate
    • Authors: Matthew Dudgeon; Ismael Carrillo-Martin, Alexei Gonzalez-Estrada
      First page: 427
      Abstract: Although a common practice, drug hypersensitivity skin tests (STs) have been standardized only with penicillin. Although STs are a practical tool, oral provocation tests (OPTs) are the gold standard in diagnosis of drug hypersensitivity and should be used when available.1 β-Lactams remain the most frequently reported cause of adverse drug reactions.2 Isolated adverse drug reactions to clavulanate, a β-lactamase inhibitor added to amoxicillin to form amoxicillin-clavulanate, remain rarer but have been reported.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-09
      DOI: 10.1016/j.anai.2019.01.005
  • Clinical communication: systemic capillary leak syndrome due to mast cell
    • Authors: Robert C. Van Winkle; J. Jeffrey Malatack, Lawrence B. Schwartz, Stephen J. McGeady
      First page: 428
      Abstract: Allergists and immunologists are consulted when a patient presents with sudden swelling and hypotension, and if there are repeated episodes and a cause is unapparent, idiopathic anaphylaxis (IA) with or without mast cell activation (MCA) may be suspected.1 Systemic capillary leak syndrome (SCLS) is defined by episodic bouts of peripheral edema and the “3 Hs”: hypotension, hemoconcentration, and hypoalbuminemia.2 The clinical findings overlap IA. We report a pediatric patient initially diagnosed with SCLS, but subsequently with IA, and consider whether the 2 are separate syndromes.
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-09
      DOI: 10.1016/j.anai.2019.01.002
  • From the pages of AllergyWatch
    • Authors: John J. Oppenheimer; David Michael Lang, Stanley M. Fineman
      First page: 436
      Abstract: J Allergy Clin Immunol Pract. 2018;6:1274-1286
      Citation: Annals of Allergy, Asthma & Immunology (2019)
      PubDate: 2019-01-24
      DOI: 10.1016/j.anai.2019.01.015
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