Subjects -> MEDICAL SCIENCES (Total: 8529 journals)
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MEDICAL SCIENCES (2342 journals)            First | 3 4 5 6 7 8 9 10 | Last

Showing 1201 - 1400 of 3562 Journals sorted alphabetically
Journal of Health Economics and Outcomes Research     Open Access   (Followers: 1)
Journal of Health Promotion and Behavior     Open Access  
Journal of Health Research and Reviews     Open Access  
Journal of Health Science and Medical Research     Open Access  
Journal of Health Science Research     Open Access  
Journal of Health Sciences     Open Access   (Followers: 1)
Journal of health sciences     Open Access  
Journal of Health Sciences / Sağlık Bilimleri Dergisi     Open Access  
Journal of Health Sciences and Medicine     Open Access  
Journal of Health Sciences and Surveillance System     Open Access  
Journal of Health Sciences Scholarship     Open Access  
Journal of Health Specialties     Open Access  
Journal of Health Studies     Open Access  
Journal of Healthcare Informatics Research     Hybrid Journal   (Followers: 1)
Journal of Heavy Metal Toxicity and Diseases     Open Access  
Journal of Helminthology     Hybrid Journal   (Followers: 2)
Journal of Herbs Spices & Medicinal Plants     Hybrid Journal  
Journal of HIV for Clinical and Scientific Research     Open Access   (Followers: 1)
Journal of Hospital Medicine     Hybrid Journal   (Followers: 10)
Journal of Huazhong University of Science and Technology [Medical Sciences]     Hybrid Journal  
Journal of Human Hypertension     Hybrid Journal   (Followers: 3)
Journal of Human Rhythm     Open Access  
Journal of Human Transcriptome     Open Access  
Journal of Ideas in Health     Open Access  
Journal of Inflammation     Open Access   (Followers: 2)
Journal of Inflammation Research     Open Access  
Journal of Injury and Violence Research     Open Access   (Followers: 7)
Journal of Innovation in Health Informatics     Open Access   (Followers: 17)
Journal of Institute of Medicine     Open Access  
Journal of Insulin Resistance     Open Access   (Followers: 1)
Journal of Interactional Research in Communication Disorders     Hybrid Journal   (Followers: 5)
Journal of Interferon & Cytokine Research     Hybrid Journal   (Followers: 3)
Journal of International Medical Research     Open Access   (Followers: 4)
Journal of Interventional Medicine     Open Access   (Followers: 1)
Journal of Investigative Medicine     Hybrid Journal   (Followers: 3)
Journal of Islamabad Medical & Dental College     Open Access  
Journal of Istanbul Faculty of Medicine     Open Access  
Journal of Karnali Academy of Health Sciences     Open Access   (Followers: 1)
Journal of Kathmandu Medical College     Open Access   (Followers: 1)
Journal of King Abdulaziz University : Medical Sciences     Open Access   (Followers: 2)
Journal of Laboratory Medicine     Hybrid Journal   (Followers: 27)
Journal of Laryngology and Voice     Open Access   (Followers: 11)
Journal of Lasers in Medical Sciences     Open Access  
Journal of Law, Medicine & Ethics     Hybrid Journal   (Followers: 24)
Journal of Legal Medicine     Hybrid Journal   (Followers: 7)
Journal of Limb Lengthening & Reconstruction     Open Access  
Journal of Lumbini Medical College     Open Access   (Followers: 1)
Journal of Mahatma Gandhi Institute of Medical Sciences     Open Access  
Journal of Manipulative and Physiological Therapeutics     Hybrid Journal   (Followers: 6)
Journal of Manmohan Memorial Institute of Health Sciences     Open Access   (Followers: 1)
Journal of Marine Medical Society     Open Access  
Journal of Materials Science : Materials in Medicine     Hybrid Journal   (Followers: 4)
Journal of Maternal and Child Health     Open Access  
Journal of Mechanics in Medicine and Biology     Hybrid Journal  
Journal of Medical and Biological Engineering     Hybrid Journal   (Followers: 4)
Journal of Medical and Biomedical Sciences     Open Access   (Followers: 2)
Journal of Medical Case Reports     Open Access   (Followers: 1)
Journal of Medical Cases     Open Access   (Followers: 6)
Journal of Medical Colleges of PLA     Full-text available via subscription  
Journal of Medical Disorders     Open Access  
Journal of Medical Economics     Hybrid Journal   (Followers: 8)
Journal of Medical Education and Curricular Development     Open Access   (Followers: 6)
Journal of Medical Ethics     Partially Free   (Followers: 25)
Journal of Medical Ethics and History of Medicine     Open Access   (Followers: 15)
Journal of Medical Humanities     Hybrid Journal   (Followers: 21)
Journal of Medical Hypotheses and Ideas     Open Access  
Journal of Medical Imaging and Health Informatics     Full-text available via subscription   (Followers: 1)
Journal of Medical Investigation and Practice     Open Access  
Journal of Medical Laboratory and Diagnosis     Open Access  
Journal of Medical Law and Ethics     Full-text available via subscription   (Followers: 15)
Journal of Medical Microbiology     Full-text available via subscription   (Followers: 6)
Journal of Medical Sciences     Open Access  
Journal of Medical Sciences     Open Access  
Journal of Medical Screening     Hybrid Journal   (Followers: 6)
Journal of Medical Signals and Sensors     Open Access   (Followers: 3)
Journal of Medical Society     Open Access  
Journal of Medical Systems     Hybrid Journal  
Journal of Medical Toxicology     Hybrid Journal   (Followers: 6)
Journal of Medical Ultrasound     Open Access   (Followers: 2)
Journal of Medicinal Botany     Open Access  
Journal of Medicinal Chemistry     Hybrid Journal   (Followers: 197)
Journal of Medicine     Open Access   (Followers: 1)
Journal of Medicine and Biomedical Research     Open Access   (Followers: 1)
Journal of Medicine and Philosophy     Hybrid Journal   (Followers: 8)
Journal of Medicine and the Person     Hybrid Journal  
Journal of Medicine in Scientific Research     Open Access  
Journal of Medicine in the Tropics     Open Access  
Journal of Medicine Research and Development     Open Access   (Followers: 3)
Journal of Medicine, Physiology and Biophysics     Open Access   (Followers: 5)
Journal of Medicines Development Sciences     Open Access   (Followers: 1)
Journal of Metabolomics & Systems Biology     Open Access  
Journal of Mind and Medical Sciences     Open Access   (Followers: 1)
Journal of Molecular Medicine     Hybrid Journal   (Followers: 11)
Journal of Movement Disorders     Open Access   (Followers: 2)
Journal of Muscle Research and Cell Motility     Hybrid Journal   (Followers: 1)
Journal of Nanotechnology in Engineering and Medicine     Full-text available via subscription   (Followers: 6)
Journal of Natural Medicines     Hybrid Journal  
Journal of Natural Science, Biology and Medicine     Open Access   (Followers: 3)
Journal of Nature and Science of Medicine     Open Access   (Followers: 4)
Journal of Negative and No Positive Results     Open Access  
Journal of Nepalgunj Medical College     Open Access  
Journal of Neurocritical Care     Open Access  
Journal of Neurodegenerative Diseases     Open Access   (Followers: 2)
Journal of Neurorestoratology     Open Access  
Journal of Neuroscience and Neurological Disorders     Open Access  
Journal of Nobel Medical College     Open Access  
Journal of Obesity and Bariatrics     Open Access  
Journal of Occupational Health     Open Access  
Journal of Occupational Therapy Education     Open Access   (Followers: 9)
Journal of Ocular Biology, Diseases, and Informatics     Hybrid Journal  
Journal of Oral Biology and Craniofacial Research     Full-text available via subscription  
Journal of Oral Health and Craniofacial Science     Open Access  
Journal of Orofacial Sciences     Open Access  
Journal of Otorhinolaryngology, Hearing and Balance Medicine     Open Access   (Followers: 1)
Journal of Ovarian Research     Open Access  
Journal of Ozone Therapy     Open Access  
Journal of Palliative Medicine     Hybrid Journal   (Followers: 47)
Journal of Paramedical Sciences & Rehabilitation     Open Access  
Journal of Parkinsonism and Restless Legs Syndrome     Open Access   (Followers: 2)
Journal of Parkinson’s Disease and Alzheimer’s Disease     Open Access  
Journal of Participatory Medicine     Open Access  
Journal of Patan Academy of Health Sciences     Open Access  
Journal of Pathogens     Open Access   (Followers: 1)
Journal of Patient Experience     Open Access  
Journal of Patient Safety and Risk Management     Hybrid Journal   (Followers: 1)
Journal of Patient-Centered Research and Reviews     Open Access  
Journal of Patient-Reported Outcomes     Open Access  
Journal of Periodontal Research     Hybrid Journal  
Journal of Personalized Medicine     Open Access   (Followers: 3)
Journal of Pest Science     Hybrid Journal   (Followers: 1)
Journal of Pharmaceutical Policy and Practice     Open Access   (Followers: 4)
Journal of Physiobiochemical Metabolism     Hybrid Journal   (Followers: 2)
Journal of Physiology-Paris     Hybrid Journal   (Followers: 2)
Journal of Pioneering Medical Sciences     Open Access  
Journal of Postgraduate Medicine     Open Access  
Journal of Pregnancy     Open Access   (Followers: 4)
Journal of Prevention & Intervention Community     Hybrid Journal   (Followers: 6)
Journal of Preventive Medicine and Public Health     Open Access  
Journal of Primary Prevention     Hybrid Journal   (Followers: 7)
Journal of Prosthodontic Research     Full-text available via subscription   (Followers: 1)
Journal of Prosthodontics     Hybrid Journal   (Followers: 2)
Journal of Receptor, Ligand and Channel Research     Open Access  
Journal of Regenerative Medicine     Partially Free   (Followers: 3)
Journal of Research in Medical Sciences     Open Access   (Followers: 2)
Journal of Science and Applications : Biomedicine     Open Access   (Followers: 1)
Journal of Science and Technology (Ghana)     Open Access   (Followers: 3)
Journal of Scientific Innovation in Medicine     Open Access  
Journal of Scientific Perspectives     Open Access   (Followers: 1)
Journal of Sensory Studies     Hybrid Journal   (Followers: 4)
Journal of Shaheed Suhrawardy Medical College     Open Access  
Journal of Shoulder and Elbow Arthroplasty     Open Access  
Journal of Sleep Disorders : Treatment & Care     Hybrid Journal   (Followers: 10)
Journal of South American Earth Sciences     Hybrid Journal   (Followers: 5)
Journal of Spinal Cord Medicine     Hybrid Journal   (Followers: 4)
Journal of Spinal Disorders & Techniques     Hybrid Journal   (Followers: 2)
Journal of Sports Medicine and Allied Health Sciences : Official Journal of the Ohio Athletic Trainers Association     Open Access   (Followers: 1)
Journal of Stem Cell Therapy and Transplantation     Open Access   (Followers: 1)
Journal of Stomal Therapy Australia     Full-text available via subscription  
Journal of Strength and Conditioning Research     Hybrid Journal   (Followers: 73)
Journal of Substance Use     Hybrid Journal   (Followers: 14)
Journal of Surgical Academia     Open Access   (Followers: 1)
Journal of Surgical and Clinical Research     Open Access  
Journal of Surgical Case Reports     Open Access  
Journal of Surgical Education     Full-text available via subscription   (Followers: 3)
Journal of Surgical Technique and Case Report     Open Access  
Journal of Systemic Therapies     Full-text available via subscription   (Followers: 3)
Journal of Taibah University Medical Sciences     Open Access  
Journal of Telemedicine and Telecare     Hybrid Journal   (Followers: 12)
Journal of The Academy of Clinical Microbiologists     Open Access  
Journal of the American Association for Laboratory Animal Science     Full-text available via subscription   (Followers: 7)
Journal of the American College of Certified Wound Specialists     Hybrid Journal   (Followers: 2)
Journal of the American College of Clinical Wound Specialists     Hybrid Journal   (Followers: 2)
Journal of the American Medical Directors Association     Hybrid Journal   (Followers: 6)
Journal of the American Medical Informatics Association : JAMIA     Hybrid Journal   (Followers: 35)
Journal of the American Podiatric Medical Association     Full-text available via subscription   (Followers: 7)
Journal of the Anatomical Society of India     Full-text available via subscription  
Journal of the Anus, Rectum and Colon     Open Access  
Journal of The Arab Society for Medical Research     Open Access  
Journal of the Australasian College of Nutritional and Environmental Medicine     Full-text available via subscription  
Journal of the Australasian Society of Aerospace Medicine     Open Access   (Followers: 1)
Journal of the Ceylon College of Physicians     Open Access  
Journal of the Chinese Medical Association     Open Access   (Followers: 2)
Journal of the College of Community Physicians of Sri Lanka     Open Access  
Journal of The Egyptian Public Health Association     Open Access   (Followers: 1)
Journal of the Formosan Medical Association     Open Access   (Followers: 2)
Journal of the Ghana Science Association     Full-text available via subscription   (Followers: 3)
Journal of the Grodno State Medical University     Open Access   (Followers: 1)
Journal of the History of Medicine and Allied Sciences     Hybrid Journal   (Followers: 17)
Journal of the International Society for Telemedicine and eHealth     Open Access   (Followers: 3)
Journal of the Learning Sciences     Hybrid Journal   (Followers: 17)
Journal of the Medical Library Association     Open Access   (Followers: 284)
Journal of the Medical Sciences (Berkala ilmu Kedokteran)     Open Access   (Followers: 1)
Journal of the National Medical Association     Full-text available via subscription  
Journal of the Peripheral Nervous System     Hybrid Journal   (Followers: 3)
Journal of the Postgraduate Institute of Medicine     Open Access  
Journal of the Renin-Angiotensin-Aldosterone System     Open Access   (Followers: 1)
Journal of the Royal Society of Medicine     Hybrid Journal   (Followers: 2)
Journal of the Ruhunu Clinical Society     Open Access  
Journal of the Scientific Society     Open Access   (Followers: 1)
Journal of the Siena Academy of Sciences     Open Access   (Followers: 1)

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Journal Cover
Journal of the Chinese Medical Association
Journal Prestige (SJR): 0.5
Citation Impact (citeScore): 1
Number of Followers: 2  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1726-4901
Published by Elsevier Homepage  [3203 journals]
  • Copyright Transfer Agreement

    • Abstract: Publication date: December 2018Source: Journal of the Chinese Medical Association, Volume 81, Issue 12Author(s):
       
  • Instruction for Authors

    • Abstract: Publication date: December 2018Source: Journal of the Chinese Medical Association, Volume 81, Issue 12Author(s):
       
  • Acknowledgments 2018

    • Abstract: Publication date: December 2018Source: Journal of the Chinese Medical Association, Volume 81, Issue 12Author(s):
       
  • Check List

    • Abstract: Publication date: December 2018Source: Journal of the Chinese Medical Association, Volume 81, Issue 12Author(s):
       
  • Authorship and Conflicts of Interest Statement

    • Abstract: Publication date: December 2018Source: Journal of the Chinese Medical Association, Volume 81, Issue 12Author(s):
       
  • Copyright Transfer Agreement

    • Abstract: Publication date: November 2018Source: Journal of the Chinese Medical Association, Volume 81, Issue 11Author(s):
       
  • Instruction for Authors

    • Abstract: Publication date: November 2018Source: Journal of the Chinese Medical Association, Volume 81, Issue 11Author(s):
       
  • Check List

    • Abstract: Publication date: November 2018Source: Journal of the Chinese Medical Association, Volume 81, Issue 11Author(s):
       
  • Assisted reproductive technology and adverse pregnancy outcome- focus
           on maternal death

    • Abstract: Publication date: November 2018Source: Journal of the Chinese Medical Association, Volume 81, Issue 11Author(s): Fa-Kung Lee, Huann-Cheng Horng, Peng-Hui Wang
       
  • Authorship and Conflicts of Interest Statement

    • Abstract: Publication date: November 2018Source: Journal of the Chinese Medical Association, Volume 81, Issue 11Author(s):
       
  • Agreement of post-LASIK corneal power and corneal thickness measurements
           by pentacam and GALILEI corneal tomography systems

    • Abstract: Publication date: Available online 26 September 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Yun-Hsiu Hsieh, Tzu-Heng Weng, Yu-Ching Chou, Kuan-Liang Wu, Chang-Min Liang, Ming-Cheng Tai BackgroundPost-LASIK corneal conditions cannot be accurately measured by traditional optometric approaches. Therefore, we aimed to analyze the agreement of two rotating Scheimpflug cameras in corneal assessment.MethodsFifty otherwise healthy volunteers who had undergone LASIK were recruited in this study. The values of mean and central total corneal power (TCP), including TCP1, TCP2, and TCP-IOL, were measured by GALILEI Scheimpflug camera. The values of total corneal refractive power (TCRP) readings at both 2 mm ring and 3 and 4 mm zones were detected by Pentacam Scheimpflug camera. Central corneal thickness (CCT) and thinnest corneal thickness (TCT) were quantified by GALILEI and Pentacam respectively. Paired t-tests and Bland–Altman analyses were used to evaluate statistical differences between measurement results obtained by GALILEI and by Pentacam.ResultsAmong these 50 subjects, the mean and central TCP1 values (37.31 ± 2.61 and 37.27 ± 2.64) derived from GALILEI measurements were consistent with the TCRP values (37.08 ± 2.76, 37.11 ± 2.74, and 37.19 ± 2.68; P > 0.05) determined by Pentacam at the 2 mm ring apex, 3 mm zone apex, and 4 mm zone apex. There were no statistically significant differences in central corneal thickness (CCT) values measured by the two cameras (463.64 ± 55.67 μm for GALILEI and 470.69 ± 44.04 μm for Pentacam, respectively; P > 0.05). However, the limits of agreement were wide when comparing mean TCP1 (−1.4 to 1.8 D, −1.4 to 1.8 D, and −1.3 to 1.6 D), central TCP1 (−1.2 to 1.6 D, −1.2 to 1.6 D, and −1.2 to 1.4 D) and CCT (−77.2–63.0 μm).ConclusionCorneal power and corneal thickness are disparate post-LASIK evaluation parameters when comparing the utility of GALILEI with that of Pentacam.
       
  • Impact of hypoxic and mesopic environments on visual acuity, contrast
           sensitivity and accommodation in subjects with LASIK surgery and aircrew
           candidate

    • Abstract: Publication date: Available online 15 September 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Hsin-Ting Lin, Hui-Ju Chan, Cheng-Wen Ho, Ming-Cheng Tai, Jiann-Torng Chen, Chang-Min Liang BackgroundThe safety of Laser-assisted in situ keratomileusis (LASIK) in aircrew was unclear, in addition, LASIK was not yet approved for aircrew of Taiwan Air Force. This study was aimed to evaluate visual performance in LASIK eyes in hypoxic and twilight environment.Methods48 myopic eyes of 24 subjects enrolled in this study were divided into LASIK group and control group. Subjects were exposed in hypoxic (15% O2) and mesopic (3 cd/m2) environment. Visual performance was evaluated using the Early Treatment of Diabetic Retinopathy Study (ETDRS) visual chart, and Functional Acuity Contrast Test (FACT) before and after the expirement. Physiological parameters of all subjects were measured and recorded throughout the experiment.ResultsThere was no significant difference of the two groups regarding their age, height, weight, and BMI. There is significant difference of preoperative spherical refractive error between the two groups. The results of physiological parameters were similar between two groups. Under normoxic conditions, there were no significant difference regarding distant vision in photopic and mesopic environments, so as for near vision. As a whole, the contrast sensitivity of the LASIK group were lowered than that of the control group about 35%, under whether normoxic or hypoxic conditions; photopic or mesopic circumstances. Under normoxic conditions, the measured accommodation of the LASIK group were 21% lowered than that of the control group and 31% lowered under hypoxic circumstances.ConclusionThere was no significant difference of visual acuity between the two groups regarding hypoxic and mesopic environment, but reduced contrast sensitivity was significant in LASIK group as compared to those of the control group. Accommodation was significantly lowered in LASIK group, compared with control group, in hypoxic environment. Whether postoperative visual performance after LASIK in aircrew during flying duty is safe might need further investigation.
       
  • Reply

    • Abstract: Publication date: Available online 7 September 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Nafiye Yılmaz, Banu Seven, Hakan Timur, Ayçağ Yorgancı, Hasan Ali İnal, Müberra Namlı Kalem, Ziya Kalem, Özge Han, Banu Bilezikçi
       
  • Fertility-enhancing agents

    • Abstract: Publication date: Available online 7 September 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Fa-Kung Lee, Peng-Hui Wang
       
  • Does continued aspirin mono-therapy lead to a higher bleeding risk after
           total knee arthroplasty'

    • Abstract: Publication date: Available online 7 September 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Cheng-Fong Chen, Shang-Wen Tsai, Po-Kuei Wu, Chao-Ming Chen, Wei-Ming Chen BackgroundEvidence about the risk of bleeding and thromboembolism because of aspirin mono-therapy in total knee arthroplasty (TKA) is scant. We wanted to validate the risks of bleeding and thromboembolism with continued aspirin mono-therapy in unilateral and simultaneous bilateral TKA.MethodsWe enrolled a series of 1655 patients who underwent unilateral or simultaneous bilateral TKA between December 2010 and December 2012. Drainage amount, postoperative hemoglobin level, change in hemoglobin, calculated blood loss, incidence and the amount of blood transfused, and the proportion of thromboembolic events were compared between patients who were and patients who were not on continued aspirin mono-therapy.ResultsCalculated blood loss (969.1 ± 324.9 vs. 904.0 ± 315.5 ml), transfusion amounts (1.3 ± 1.5 vs. 1.0 ± 1.3 IU), and percentage of transfused patients (53.0% vs. 40.2%) were higher in unilateral TKA patients on continued aspirin mono-therapy. Outcome parameters and the proportion of DVT between groups were not significantly different. One patient (0.3%) not on aspirin mono-therapy developed a pulmonary embolism, and two others (0.6%) had cerebrovascular events.ConclusionDespite the slightly higher risks of bleeding, continuing aspirin mono-therapy during TKA might be safe with low risks of perioperative cerebrovascular, cardiovascular, and venous thromboembolic events.
       
  • Effect of ivabradine, a funny current inhibitor, on portal hypertensive
           rats

    • Abstract: Publication date: Available online 6 September 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Ching-Chih Chang, Wen-Shin Lee, Chiao-Lin Chuang, I-Fang Hsin, Shao-Jung Hsu, Hui-Chun Huang, Fa-Yauh Lee, Shou-Dong Lee BackgroundIvabradine is a funny current inhibitor which is administered to patients with congestive heart failure to reduce their heart rate (HR) and attenuate oxidative stress. Chronic liver diseases are characterized by portal hypertension and hyperdynamic circulation with tachycardia. The present study aimed to investigate the effect of ivabradine on portal hypertension.MethodsMale Sprague–Dawley rats received partial portal vein ligation (PVL) to induce portal hypertension. The PVL rats were randomly allocated to receive either vehicle or ivabradine treatment for 10 days. Then the hemodynamic data were collected. The levels of oxidative stress markers and the mRNA expression of nitric oxide synthase (NOS) were measured in the collateral vessel, the superior mesentery artery and the liver. In addition, the collateral vascular responsiveness to arginine vasopressin (AVP) was examined in the ivabradine-treated and vehicle-treated PVL rats.ResultsTreatment with ivabradine significantly lowered the HR (174 ± 20 vs. 374 ± 9 beats/min; p 
       
  • The use of time-domain analysis on the choice of measurement location
           for pulse diagnosis research: A pilot study

    • Abstract: Publication date: Available online 6 September 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Yun-Ning Tsai, Yu-Hsin Chang, Yi-Chia Huang, Sunny Jui-Shan Lin, Shen-Ming Lee, Yung-Yen Cheng, Yi-Chang Su BackgroundPulse diagnosis researches acquiring pulse waves from the wrist radial artery has not yet addressed the issue of whether this information is affected by differences in the hemodynamic characteristics of pressure waves derived from different locations. This study aimed to clarify whether the blood dynamic states are identical with regard to the “three positions and nine indicators” (三部九候) listed in traditional Chinese medicine (TCM).MethodsA total of 37 participants of CAD group and 20 participants of healthy group were recruited, and pressure pulse waves were measured at 18 locations on both hands. A multivariate analysis (MANOVA) was performed with a “randomized block design” using SPSS 22.0 and R 3.4.1 to examine the time-domain parameters that represented certain hemodynamic characteristics.ResultsIn CAD group, the results showed significant differences (p 
       
  • Evaluation of peripheral blood NK cell subsets and cytokines in
           unexplained recurrent miscarriage

    • Abstract: Publication date: Available online 23 August 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Hajar Adib Rad, Zahra Basirat, Amrollah Mostafazadeh, Mahbobeh Faramarzi, Ali Bijani, Hamid Reza Nouri, Shima Soleimani Amiri BackgroundRecurrent miscarriage is considered as one of the main problems in women's reproductive health. The aim of the present study was to evaluate the natural killer cells (NK cells) and cytokines in unexplained recurrent miscarriage and fertile women.MethodsIn this case–control study, 40 women with unexplained recurrent miscarriage were assigned to the case group and 40 fertile women were assigned to the control group. NK cell subsets (CD56+ CD16+/CD56+ CD16-) and cytokines (IL-2/IL-12) levels in the peripheral blood (PB) were used for assessing immunologic problems. The percentage of peripheral blood NK cells (CD56dim/bright) was identified by flow cytometry.ResultsThe obtained results showed a significant difference in CD56+ CD16+ and CD56+ CD16- between the two groups. Also, there was no significant difference in the IL-2 and IL-12 between the two groups. A cut-off value of ≥5.25% (p 
       
  • Evaluating cerebral hemodynamics using quantitative digital subtraction
           angiography and flat-detector computed tomography perfusion imaging: A
           comparative study in patients with carotid stenosis

    • Abstract: Publication date: Available online 23 August 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Liang-Wei Chen, Chung-Jung Lin, Wan-Yuo Guo, Sheng-Che Hung, Han-Jui Lee, Ko-Kung Chen, Feng-Chi Chang, Chao-Bao Luo, Wei-Fa Chu BackgroundThe efficacy of both quantitative digital subtraction angiography (QDSA) and flat-detector computed tomography perfusion (FD-CTP) is equivalent to that of magnetic resonance perfusion (MRP) in assessing perfusion deficits in carotid stenosis. This study evaluated the feasibility of using FD-CTP to monitor cerebral hemodynamics during carotid stenting.MethodsThirteen patients with extracranial carotid stenosis (>70%) were included. Both QDSA and two FD-CTP sessions were performed before and after carotid stenting. Cerebral circulation time (CCT) was defined as the difference between the time to peak (TTP) of the parietal vein and the cavernous internal carotid artery. For FD-CTP and MRP, regions of interest (ROIs) were placed in the middle cerebral artery territory at the basal ganglia level of both stenotic and contralateral hemispheres for measurement. The TTP ratio (rTTP) was defined as stenotic TTP divided by contralateral TTP; and ratio of cerebral blood volume (rCBV), ratio of mean transit time (rMTT), and ratio of cerebral blood flow (rCBF) were defined similarly. Both CCT and ratio perfusion parameters were compared during stenting.ResultsBefore stenting, only rCBF (r = 0.73) and rTTP (r = 0.58) demonstrated correlations between FD-CTP and MRP; CCT correlated with only rMTT in MRP (r = 0.69). After stenting, only rCBF (r = 0.56) indicated a correlation between FD-CTP and MRP. Regarding cerebral flow after stenting, CCT (4.61 ± 1.6 s) was shortened, rMTT (1.12 ± 0.04) and rTTP (r = 1.05 ± 0.03) decreased, and rCBF (0.91 ± 0.16) increased significantly.ConclusionFD-CTP provides a potentially more comprehensive hemodynamic assessment of parenchymal perfusion changes compared with QDSA during carotid stenting, but FC-CTP requires additional 18 min. FD-CTP confirmed that the normalization of cerebral hemodynamics began immediately and continued for 1–3 days.
       
  • Correlations between serum hepatitis B surface antigen and hepatitis B
           core antibody titers and liver fibrosis in treatment-naïve CHB patients

    • Abstract: Publication date: Available online 22 August 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Min-Ran Li, Huan-Wei Zheng, Shun-Mao Ma, Yun-Yan Liu, Lan-Xia Qie, Jun-Qing Li, De-Hua Wang, Xing-Li Sun, Gui-Fang Ren, Yan-Hua Zheng, Yu-Ling Wang, Er-Hei Dai BackgroundPrevious studies have revealed that quantitative hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (qAnti-HBc) levels can be used as predictors of treatment response in both interferon-α and nucleoside analogue therapies. Few data have been published regarding the relationship between quantitative HBsAg or Anti-HBc levels and liver fibrosis stages in patients with chronic hepatitis B (CHB).MethodsWe conducted a cross-sectional study of treatment-naïve CHB patients. A total of 624 CHB patients were recruited. We assessed the serum HBsAg and qAnti-HBc levels, HBV DNA levels, HBV genotypes, BCP/PC mutations, histological fibrosis staging by Scheuer classification.ResultsIn HBeAg (+) patients, the S0-1 subjects had significantly higher serum HBsAg and lower qAnti-HBc levels than the S2-4 subjects (both p 
       
  • ALBI grade as a new player in hepatocellular carcinoma

    • Abstract: Publication date: Available online 20 August 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Teh-Ia Huo
       
  • Baicalein attenuates neuropathic pain and improves sciatic nerve function
           recovery in rats with partial sciatic nerve transection

    • Abstract: Publication date: Available online 20 August 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Hou-Chuan Lai, Chueng-He Lu, Chih-Shung Wong, Bo-Feng Lin, Shun-Ming Chan, Chan-Yang Kuo, Zhi-Fu Wu BackgroundModulating the inflammatory response to nerve injury may provide therapeutic opportunities by aborting the neurobiological alterations that support the development of persistent pain. Baicalein, a 12-lipoxygenase inhibitor, has anti-inflammation properties. It also demonstrates anti-inflammatory functions by inhibiting lipopolysaccharide-induced barrier disruption, expression of cell adhesion molecules, and adhesion and migration of leukocytes. The aim of the present study was to assess the possibility of early treatment of neuropathic pain via the systemic injection of baicalein in rats with left partial sciatic nerve transection (PST).MethodsWistar rats were divided into Sham, Vehicle, and Baicalein groups. The Vehicle and Baicalein rats underwent PST, whereas the Sham rats were not transected. Baicalein was administered 20 mg/kg/day intraperitoneally for 7 days after PST and after behaviour tests. After PST, rats developed mechanical and cold allodynia, and impaired sciatic nerve function.ResultsBaicalein attenuated mechanical and cold allodynia and improved sciatic nerve function after PST. Baicalein significantly inhibited the expression of tumour necrosis factor α (TNF-α), interleukin 6 (IL-6), and IL-1β on days 14 and 28, and attenuated the activation of astrocytes in the L4–5 spinal cord less than day 28 after PST.ConclusionOur study revealed that early and multiple doses of systemic baicalein attenuated neuropathic pain and improved sciatic nerve function by inhibiting pro-inflammatory cytokine expression and attenuating the activation of astrocytes in the spinal cord.
       
  • Patient response prediction with logistic regression in gastrointestinal
           endoscopy under midazolam-alfentanil sedation performed as well as
           response surface model

    • Abstract: Publication date: Available online 18 August 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Mei-Yung Tsou, Jing-Yang Liou, Chien-Kun Ting, Shih-Pin Lin BackgroundResearchers have used logistic regression (LR) and non-linear response surface models (RSMs) to predict patient responses to sedation. The reduced Greco and hierarchy RSMs have proven to be more appropriate than other RSMs in gastrointestinal endoscopies using midazolam and alfentanil. In this study, we evaluate the performance of a simpler model, LR, and compared it with that of RSM.MethodsThirty-three patients who received esophagogastroduodenoscopy (EGD) and colonoscopy sedation with midazolam and alfentanil were enrolled in the study. LR was performed for the EGD group and validated using the colonoscopy group. The two RSMs were performed using the same process, and performances and receiver operating characteristic (ROC) curves of the models were evaluated.ResultsThe native EGD LR model had an ROC curve area of 0.94. For external validation, the ROC curves were 0.92, 0.94, and 0.94 for the reduced Greco, hierarchy, and LR models, respectively. Pairwise comparison between models was not significant.ConclusionThe LR model performed as well as RSM in generalizing the predicted sedative effect of midazolam and alfentanil during gastrointestinal endoscopies. LR may be used for generalization across patients experiencing procedures with similar stimulus intensities.
       
  • The effect of inhaled salbutamol on the outcomes of transient tachypnea of
           the newborn

    • Abstract: Publication date: Available online 18 August 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Arash Malakian, Masoud Dehdashtian, Mohammad Raza Aramesh, Mohammad Hassan Aletayeb, Solmaz Heidari BackgroundTransient tachypnea of the newborn (TTN) is a self-limiting disease that results from a reduction in the rate of lung fluid clearance in neonates. A delay in lung fluid absorption in neonates disrupts the transition from intrauterine to extrauterine life. Use of beta-adrenergic antagonists, such as salbutamol, accelerates lung fluid clearance. The current study aimed to evaluate the effect of inhaled salbutamol on the clinical progression of TTN treatment.MethodsIn the current triple-blind clinical trial, a total of 148 inpatients diagnosed with TTN were randomly divided into 2 groups. The treatment group (n = 74) received inhaled salbutamol and the placebo group (n = 74) received inhaled normal saline. The drug administration was started 6 h after birth and continued in the case of continued respiratory distress and the need for oxygen as adjuvant therapy for up to 72 h maximum after the initiation of treatment. To evaluate the response to treatment with inhaled salbutamol, we assessed the respiratory rate (RR), heart rate (HR), fraction of inspired oxygen (FIO2) level, and O2 saturation at intervals of 30 min as well as 1 h and 4 h after drug administration. The results were compared between the groups.ResultsThe results of the current study indicated a significant difference between the treatment and placebo groups in the treatment duration, hospitalization duration, need for continuous positive airway pressure therapy (CPAP), and time of oral feeding initiation. In addition, no complication was observed during the treatment. It is noteworthy that, following the improvement of disease symptoms and reduction of hospitalization. This reduction may decrease the treatment costs and anxiety of parents, which was associated with proper mental and economic outcomes.ConclusionAlthough, in the current study, drug administration was continued for 72 h maximum, the prescription of at most 4 doses of salbutamol may have had maximum efficiency in the remediation process. To evaluate the therapeutic role of inhaled salbutamol, further studies are recommended.
       
  • Comparison of cancer detection between 18- and 12-core prostate biopsy in
           Asian patients with prostate-specific antigen levels of 4–20 ng/mL

    • Abstract: Publication date: Available online 9 August 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Bo-Ren Wang, Cheng Che Chen, Ren-Hao Zheng, Ju-Chuan Hu, Yen-Chuan Ou BackgroundAlthough prostate biopsy is an accepted option for cancer detection, there is little data regarding the clinical outcome of 18-core transrectal ultrasound (TRUS)-guided biopsy. This retrospective study compared cancer detection rates and biopsy complications between 12- and 18-core TRUS biopsy in Asian patients with prostate-specific antigen (PSA) levels between 4.0 and 20.0 ng/mL.MethodsIn total, 1120 consecutive patients with PSA levels between 4.0 and 20.0 ng/mL were divided into the 12-core (552 patients) and 18-core TRUS biopsy (568 patients) groups. The clinical outcomes of the 12- and 18-core TRUS-biopsy groups were compared. Clinical outcomes were evaluated by comparing the prostate cancer detection rates and post-biopsy complication rates.ResultsThere were no significant group differences in the PSA levels, but the mean age was significantly older in the 12-core biopsy group than in the 18-core biopsy group (mean age, 67.0 vs. 64.0 years, respectively; p = 0.001). The abnormal digital rectal examination rate was higher in the 12-core biopsy group than in the 18-core biopsy group (39.9% vs. 24.5%, respectively; p 
       
  • Histological study of the protective role of ginger on piroxicam-induced
           liver toxicity in mice

    • Abstract: Publication date: Available online 9 August 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Marwa Sayed Badawi BackgroundPiroxicam is a non-steroidal anti-inflammatory drug widely used in rheumatic diseases. It has analgesic and antipyretic activity, and is one of the drugs being introduced in clinical practice. Piroxicam-hepatotoxicity has been reported as one of its principal side effects. Several natural antioxidants were found to be effective against drug induced toxicity. Ginger is known by its antioxidant activities and hepatoprotective effects. The present study aimed at studying the protective effect of Ginger on Piroxicam-induced histopathological changes in livers of male mice.MethodsForty adult mice were randomly divided into 4 groups: Group I served as the control group. Group ІІ received Ginger orally in a dose of 200 mg/kg per day for four weeks. Group ІІI received Piroxicam intraperitoneally in a dose of 0.3 mg/kg per day for four weeks. Group ІV received (Piroxicam + Ginger). At the end of the experiment, liver functions were estimated and then the liver was removed, and sampled for histopathological, immunohistochemistry and biochemical studies.ResultsAdministration of ginger decreased elevated serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) and immunoexpression of the proapoptotic protein (Bax), induced by piroxicam. It increased immunoexpression of the antiapoptotic protein (Bcl2). It also ameliorated the morphological changes induced by piroxicam.ConclusionPiroxicam has toxic effects on the liver as indicated by biochemical, histological and immunohistochemical results. Ginger has protective effects against piroxicam-hepatotoxicity by reducing serum marker enzymes, liver fibrosis and apoptosis.
       
  • Early achievement of full donor chimerism after allogeneic hematopoietic
           stem cell transplantation predicts lower relapse risk in patients with
           acute lymphoblastic leukemia

    • Abstract: Publication date: Available online 9 August 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Chien-Ting Chen, Jyh-Pyng Gau, Jing-Hwang Liu, Tzeon-Jye Chiou, Liang-Tsai Hsiao, Yao-Chung Liu BackgroundAcute lymphoblastic leukemia (ALL) remains one of the most difficult-to-cure hematological malignancies. Allogeneic hematopoietic stem cell transplantation (HSCT) provides curative potential but a substantial proportion of patients eventually will relapse. It is unknown if there are any modifiable factors exists that could improve survival or predict relapse immediately after HSCT is unknown. The aim of this study was to explore whether achieving early (
       
  • Nebulized salbutamol diminish the blood glucose fluctuation in the
           treatment of non-oliguric hyperkalemia of premature infants

    • Abstract: Publication date: Available online 19 July 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Hean-Pat Saw, Cheng-Di Chiu, You-Pen Chiu, Hui-Ru Ji, Jia-Yuh Chen BackgroundHyperkalemia is a risky and potentially life-threatening condition in pre-term infants. Glucose-insulin infusion has been considered a major therapeutic way for non-oligouric hyperkalemia but affects the stability of blood sugar level. We aimed to evaluate the effectiveness of salbutamol nebulization compared to glucose-insulin infusion for the treatment of non-oliguric hyperkalemia in premature infants.MethodsForty premature infants (gestation age ≤36 weeks) with non-oliguric hyperkalemia (central serum potassium level greater than 6.0 mmol/L) within 72 h of birth were enrolled in this study. These infants were randomly assigned into two groups. One group received a regular insulin bolus with glucose infusion (Group A; n = 20), and the other received salbutamol (Ventolin®) by nebulization (Group B; n = 20). Potassium level, blood sugar, heart rate, and blood pressure were recorded for each group before treatment and at 3, 12, 24, 48, and 72 h post-treatment.ResultsThe serum potassium levels were reduced after treatment in both groups. No significant changes in heart rate or blood pressure were observed in either group. The fluctuation in glucose levels was gentler in the salbutamol-treated group than in the glucose-insulin infusion group.ConclusionSalbutamol nebulization is not only as effective as glucose-insulin infusion for treating non-oliguric hyperkalemia in premature infants but can avoid potential side effects such as vigorous blood glucose fluctuations.
       
  • Involvement of S100A4/Mts1 and associated proteins in the protective
           effect of fluoxetine against MCT – Induced pulmonary hypertension in
           rats

    • Abstract: Publication date: Available online 19 July 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Zhan-Hong Song, Han-Ming Wang, Ming Liu, Yang Bai, Yun Wang, Huai-Liang Wang BackgroundPulmonary arterial hypertension (PAH) is a complex pulmonary vasculature disease characterized by remodeling of the pulmonary vessels and a persistent increase in the pulmonary vascular resistance (PVR) with a poor prognosis. Serotonin increases the expression of S100A4/Mts1, which in turn stimulates the proliferation and migration of human pulmonary artery smooth muscle cells through the interaction with RAGE (receptor for advanced glycation end products) and thus S100A4/Mts1 has been implicated in the development of PAH in vitro. Fluoxetine, a selective serotonin re-uptake inhibitor has been shown to protect against PAH. The current study was designed to test whether S100A4 and its associated proteins connected in the development of PAH in vivo as well as to investigate the involvement of those proteins in the protective effect of fluoxetine against PAH.MethodsMCT-induced PAH models were established in Wistar rats by a single intraperitoneal injection of MCT (60 mg/kg). Fluoxetine (2 and 10 mg/kg/day) was intragastrically administered once a day for 3 weeks along with controls. The detection methods followed include Hematoxylin and Eosin (H&E) staining, immunohistochemistry, western blotting and real-time reverse transcription-polymerase chain reaction (RT-PCR).ResultsMCT induced pulmonary hypertension, pulmonary vascular remodeling, and right ventricular hypertrophy significantly increased the expressions of S100A4 and RAGE in the pulmonary arteries, lungs and right ventricle (RV). Fluoxetine dose-dependently inhibited MCT-induced pulmonary arterial hypertension, pulmonary vascular remodeling, and right ventricular hypertrophy and reduced the S100A4 and RAGE. Further analysis revealed that fluoxetine alleviated both the increase of p53, MMP13, MMP2 and MMP9 and the decrease of pp53Ser15 and MDM2 in lungs and RV tissues of MCT-induced PAH rats.ConclusionFrom the present investigation it could be concluded that S100A4/Mts1 and its associated proteins are involved in the evolution of MCT-induced PAH in rats and fluoxetine inhibits MCT-induced PAH in rats mainly through S100A4/RAGE signaling axis and involved factors.
       
  • Use of prokinetic agents or antibiotics is associated with the occurrence
           of spontaneous bacterial peritonitis in cirrhotic patients

    • Abstract: Publication date: Available online 13 July 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Yun-Cheng Hsieh, Ming-Hsun Lee, Kuei-Chuan Lee, Ying-Ying Yang, Ming-Chih Hou, Han-Chieh Lin BackgroundProkinetics have been shown to improve intestinal bacterial overgrowth and dysmotility in cirrhotic patients. Antibiotics are suggested for high risk patients for prophylaxis of spontaneous bacterial peritonitis (SBP). However, limited studies have investigated the association of SBP and these medications. We examined the association of prokinetics or antibiotics use and the first episode of SBP development in patients with cirrhosis.MethodsWe conducted a case-crossover study using the Taiwanese National Health Insurance Research Database from 2001 to 2010. A total of 129 cirrhotic patients with SBP were identified (defined as International Classification of Disease-Ninth Revision-CM codes: 571.xx for cirrhosis; 567.2, 567.8, and 567.9 for ascites; 789.5 for SBP). We investigated the short term (defined as 14-day period) effect of prokinetic agents or antibiotics use on SBP development using conditional logistic regressions with the adjustment of potential confounders.ResultsThe results suggested that prokinetic agents or antibiotics use during the 14 days before SBP were associated with an increased risk of SBP [adjusted odds ratio (OR) = 3.2, 95% confidence interval (CI): 1.02–10.04 for prokinetic agents; and adjusted OR = 2.95, 95% CI: 1.05–5.23 for antibiotics]. In dose analysis, the use of prokinetic agents more than 0.5 defined daily dose was more commonly found in the case period without a statistical difference (adjusted OR = 3.637; 95% CI: 0.69–19.13).ConclusionThe results demonstrated an increased risk of primary SBP development among cirrhotic patients with prokinetic agents or antibiotics use. It is important to closely monitor those patients for the occurrence of SBP.
       
  • Composition of urinary tract stones formed by children in two populations
           in the Uyghur region of China

    • Abstract: Publication date: Available online 13 July 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Jian Huang, Aierken Tuerxun, Hamulati Tusong, Abudukahaer Batuer, Hans-Göran Tiselius, Zhijian Zhao, Zanlin Mai, Guohua Zeng, Wenqi Wu BackgroundTo retrospectively compare the composition of urinary tract stones formed by Uyghur children from the southern (Kashgar) and northern (Urumchi) parts of the Xinjiang region.MethodsThe chemical composition of urinary tract calculi formed by 855 Uyghur children from the two regions in Xinjiang (366 Kashgar and 489 Urumchi) was compared retrospectively. Stone composition was determined by infrared spectroscopy. Factors that might have been of relevance for the findings such as age, gender, stone location and geographic region were also considered.ResultsKashgar children were younger than Urumchi children (2.8 ± 2.7 vs. 4.3 ± 3.7 years, p 
       
  • Characterization and management of various renal cystic lesions by
           sonographic features

    • Abstract: Publication date: Available online 13 July 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Shee-Yen Tay, Chui-Mei Tiu, Bing Hu, Hsin-Kai Wang, Hong-Jen Chiou, Yung-Hui Lin, Yi-Chen Lai, Wing P. Chan, Yi-Hong Chou Renal cysts are common incidental findings in clinical practice. Most renal cysts detected in medical imaging are benign simple cysts. However, some are complicated by hemorrhage or infection or are associated with calcification. In these instances, difficulties can be encountered distinguishing the complicated cysts from cystic renal tumors such as cystic renal cell carcinoma, multilocular cystic nephroma, and mixed epithelial and stromal tumors. The Bosniak classification is widely used to categorize cystic renal lesions but is used to classify those discovered via computed tomography. Ultrasonography (US) and color Doppler US are the most frequently used imaging techniques for abdominal surveys and long-term follow-up because of their noninvasiveness, relatively low cost, wide availability, and frequently, lack of contrast medium. Herein, we review the features of various cystic lesions of the kidney that can be found using US, discuss differential diagnoses using US, and propose a feature-oriented algorithmic approach to classifying renal cystic lesions using US.
       
  • Accuracy of implant placement with a computer-aided fabricated surgical
           template with guided parallel pins: A pilot study

    • Abstract: Publication date: Available online 30 June 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Rai-Jei Chang, Hui-Ling Chen, Liang-Gie Huang, Yong-Kie Wong BackgroundA precise positioning for dental implant placement is important for further prosthesis fabrication and maintenance. Computer-aided surgery has been developed to transfer digitally planned implant positioning to the patient over the past decades. This study aimed to evaluate the accuracy of a computer-aided laboratory-fabricated surgical template. A further objective was to compare the accuracy between in vivo and in vitro groups.MethodsA total of 20 implants were placed in the posterior tooth region through the aid of surgical templates on 17 partially edentulous patients in the in vivo group. The surgical template was fabricated in laboratory after virtual implant planning was completed using computer software. In the in vitro group, the same procedures were performed on the models without placing fixture with the same templates used in surgery. Deviations of the implant access at the implant platform level and apical region, as well as the angle deviations between the virtual planning data and the surgical results, were measured using a follow-up Cone Beam Computerized Tomography (CBCT) investigation, and image fusion with planning data.ResultThe median deviation at platform level, apex and angulation was 0.95 mm (0.3–1.3 mm),1.35 mm (0.1–3.6 mm) and 3.92° (0.44–11.66°) respectively in the in vivo group; and 0.4 mm (0–1.0 mm), 0.65 mm (0.1–1.9 mm), 2.16° (0.17–6.91) respectively in the in vitro group. The in vitro group displayed significantly less deviation (p 
       
  • Linked color imaging can help gastric Helicobacter pylori infection
           diagnosis during endoscopy

    • Abstract: Publication date: Available online 31 May 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Tsung-Hsing Chen, Chen-Ming Hsu, Hao-Tsai Cheng, Yin-Yi Chu, Ming-Yao Su, Jun-Te Hsu, Ta-Sen Yeh, Chang-Fu Kuo, Cheng-Tang Chiu BackgroundEsophagogastroduodenoscopy (EGD) is a standard tool for detection of mucosal and submucosal lesions. However, identification of Helicobacter pylori (H. P) infection using EGD alone is limited in accuracy. Linked color imaging (LCI) is a novel tool to capture real-time image with sufficient contrast to observe mucosal microstructure.MethodsThis study aims to evaluate the applicability of LCI in the identification of H. pylori infection. Consecutive 122 patients scheduled for EGD were included. They were examined with LCI and magnifying endoscopy. The classification of H. pylori was based on pathology results of biopsy and rapid urease test or urea breath test.ResultsWe compared the results based on LCI or magnifying endoscopy to reference classification. Of 122 patients, 36 had H. pylori infection (29.51%). The level of accuracy of diagnosis of H. pylori infections by LCI, magnifying endoscopy, and both LCI and magnifying endoscopy was 78.38%, 81.98%, and 78.38%, respectively. The sensitivity and specificity of each group were 70.97%, 81.25%, and 80.65% and 82.5%, 83.87%, and 76.25%, respectively. The positive predictive values were 59.46%, 64.10%, and 57.78%, respectively, and the negative predictive values were 87.84%, 91.67%, and 92.42%, respectively.ConclusionLCI could be playing a valuable initial screen tool for real-time diagnosis of H. pylori infections. It has a high accuracy of diagnosis of H. pylori infections. Therefore, in patients suspected to have H. pylori infections using LCI, the infections need to be carefully diagnosed using appropriate methods because, as per the consensus, they should be eradicated as soon as possible before precancerous lesions develop.
       
  • Risk factors of the peptic ulcer bleeding in aging uremia patients under
           regular hemodialysis

    • Abstract: Publication date: Available online 31 May 2018Source: Journal of the Chinese Medical AssociationAuthor(s): Xi-Hsuan Lin, Chung-Chi Lin, Yuan-Jen Wang, Jiing-Chyuan Luo, Shih-Hao Young, Ping-Hsien Chen, Ming-Chih Hou, Fa-Yauh Lee BackgroundPrevious studies have shown that uremia patients under hemodialysis (HD) have a significantly higher occurrence of peptic ulcer bleeding (PUB) than healthy controls and that elderly patients remain at high risk of peptic ulcer disease (PUD) and PUB. Here we aimed to identify the risk factors for PUB in aging (≥65-years-old) uremic patients under regular HD.MethodsUsing data from the National Health Insurance Research Database of Taiwan, we compared 18,252 aging regular HD patients and 17,883 age-, gender-, and medication-matched patients without kidney disease (control group). The log-rank test was performed to analyze the differences in accumulated hazard of PUB between the two groups. Cox proportional hazard regressions were performed to evaluate independent risk factors for PUB between the two groups and identify risk factors of PUB in aging HD patients.ResultsIn a 7-year follow-up, aging HD patients had significantly higher incidences of PUB than the matched controls (p 
       
 
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