Subjects -> MEDICAL SCIENCES (Total: 8690 journals)
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MEDICAL SCIENCES (2415 journals)            First | 3 4 5 6 7 8 9 10 | Last

Showing 1201 - 1400 of 3562 Journals sorted alphabetically
Journal of Evaluation In Clinical Practice     Hybrid Journal   (Followers: 6)
Journal of Evidence-Based Healthcare     Open Access   (Followers: 1)
Journal of Evidence-Based Integrative Medicine     Open Access   (Followers: 18)
Journal of Evidence-Based Medicine     Partially Free   (Followers: 4)
Journal of Exercise Science & Fitness     Open Access   (Followers: 29)
Journal of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
Journal of Family and Community Medicine     Open Access   (Followers: 3)
Journal of Family Medicine and Primary Care     Open Access   (Followers: 11)
Journal of Foot and Ankle Research     Open Access   (Followers: 6)
Journal of Forensic Science and Research     Open Access   (Followers: 2)
Journal of Gandaki Medical College-Nepal     Open Access  
Journal of Generic Medicines     Hybrid Journal   (Followers: 2)
Journal of Geographical Sciences     Hybrid Journal   (Followers: 1)
Journal of Global Antimicrobial Resistance     Hybrid Journal   (Followers: 3)
Journal of Hand Therapy     Hybrid Journal   (Followers: 19)
Journal of Head & Neck Physicians and Surgeons     Open Access   (Followers: 2)
Journal of Health & Medical Informatics     Open Access   (Followers: 62)
Journal of Health and Biological Sciences     Open Access   (Followers: 1)
Journal of Health Design     Open Access   (Followers: 1)
Journal of Health Economics and Outcomes Research     Open Access   (Followers: 1)
Journal of Health Promotion and Behavior     Open Access  
Journal of Health Research and Reviews     Open Access  
Journal of Health Science and Medical Research     Open Access  
Journal of Health Science Research     Open Access  
Journal of Health Sciences     Open Access   (Followers: 1)
Journal of health sciences     Open Access  
Journal of Health Sciences / Sağlık Bilimleri Dergisi     Open Access  
Journal of Health Sciences and Medicine     Open Access  
Journal of Health Sciences and Medicine     Open Access   (Followers: 6)
Journal of Health Sciences and Surveillance System     Open Access  
Journal of Health Sciences Scholarship     Open Access  
Journal of Health Specialties     Open Access  
Journal of Health Studies     Open Access  
Journal of Healthcare Informatics Research     Hybrid Journal   (Followers: 1)
Journal of Heavy Metal Toxicity and Diseases     Open Access  
Journal of Helminthology     Hybrid Journal   (Followers: 2)
Journal of Herbs Spices & Medicinal Plants     Hybrid Journal  
Journal of HIV for Clinical and Scientific Research     Open Access   (Followers: 2)
Journal of Hospital Medicine     Hybrid Journal   (Followers: 11)
Journal of Huazhong University of Science and Technology [Medical Sciences]     Hybrid Journal  
Journal of Human Hypertension     Hybrid Journal   (Followers: 3)
Journal of Human Rhythm     Open Access  
Journal of Human Transcriptome     Open Access  
Journal of Ideas in Health     Open Access  
Journal of Inflammation     Open Access   (Followers: 2)
Journal of Inflammation Research     Open Access  
Journal of Injury and Violence Research     Open Access   (Followers: 6)
Journal of Innovation in Health Informatics     Open Access   (Followers: 17)
Journal of Institute of Medicine     Open Access  
Journal of Insulin Resistance     Open Access   (Followers: 1)
Journal of Interactional Research in Communication Disorders     Hybrid Journal   (Followers: 5)
Journal of Interferon & Cytokine Research     Hybrid Journal   (Followers: 3)
Journal of International Medical Research     Open Access   (Followers: 3)
Journal of Interventional Medicine     Open Access   (Followers: 1)
Journal of Investigative Medicine     Hybrid Journal   (Followers: 3)
Journal of Islamabad Medical & Dental College     Open Access   (Followers: 2)
Journal of Istanbul Faculty of Medicine     Open Access  
Journal of Karnali Academy of Health Sciences     Open Access   (Followers: 1)
Journal of Kathmandu Medical College     Open Access   (Followers: 1)
Journal of King Abdulaziz University : Medical Sciences     Open Access   (Followers: 2)
Journal of Laboratory Medicine     Hybrid Journal   (Followers: 27)
Journal of Laryngology and Voice     Open Access   (Followers: 11)
Journal of Lasers in Medical Sciences     Open Access  
Journal of Law, Medicine & Ethics     Hybrid Journal   (Followers: 28)
Journal of Legal Medicine     Hybrid Journal   (Followers: 7)
Journal of Limb Lengthening & Reconstruction     Open Access  
Journal of Lumbini Medical College     Open Access   (Followers: 1)
Journal of Mahatma Gandhi Institute of Medical Sciences     Open Access  
Journal of Manipulative and Physiological Therapeutics     Hybrid Journal   (Followers: 6)
Journal of Manmohan Memorial Institute of Health Sciences     Open Access   (Followers: 1)
Journal of Marine Medical Society     Open Access  
Journal of Materials Science : Materials in Medicine     Hybrid Journal   (Followers: 4)
Journal of Maternal and Child Health     Open Access  
Journal of Mechanics in Medicine and Biology     Hybrid Journal  
Journal of Medical and Biological Engineering     Hybrid Journal   (Followers: 4)
Journal of Medical and Biomedical Sciences     Open Access   (Followers: 2)
Journal of Medical Case Reports     Open Access   (Followers: 1)
Journal of Medical Cases     Open Access   (Followers: 6)
Journal of Medical Colleges of PLA     Full-text available via subscription  
Journal of Medical Disorders     Open Access  
Journal of Medical Economics     Hybrid Journal   (Followers: 8)
Journal of Medical Education and Curricular Development     Open Access   (Followers: 6)
Journal of Medical Ethics     Partially Free   (Followers: 27)
Journal of Medical Ethics and History of Medicine     Open Access   (Followers: 19)
Journal of Medical Humanities     Hybrid Journal   (Followers: 21)
Journal of Medical Hypotheses and Ideas     Open Access  
Journal of Medical Imaging and Health Informatics     Full-text available via subscription   (Followers: 1)
Journal of Medical Investigation and Practice     Open Access  
Journal of Medical Laboratory and Diagnosis     Open Access  
Journal of Medical Law and Ethics     Full-text available via subscription   (Followers: 17)
Journal of Medical Microbiology     Full-text available via subscription   (Followers: 6)
Journal of Medical Sciences     Open Access  
Journal of Medical Sciences     Open Access  
Journal of Medical Screening     Hybrid Journal   (Followers: 6)
Journal of Medical Signals and Sensors     Open Access   (Followers: 3)
Journal of Medical Society     Open Access  
Journal of Medical Systems     Hybrid Journal  
Journal of Medical Toxicology     Hybrid Journal   (Followers: 6)
Journal of Medical Ultrasound     Open Access   (Followers: 2)
Journal of Medicinal Botany     Open Access  
Journal of Medicinal Chemistry     Hybrid Journal   (Followers: 208)
Journal of Medicine     Open Access   (Followers: 1)
Journal of Medicine and Biomedical Research     Open Access   (Followers: 1)
Journal of Medicine and Philosophy     Hybrid Journal   (Followers: 9)
Journal of Medicine and the Person     Hybrid Journal  
Journal of Medicine in Scientific Research     Open Access  
Journal of Medicine in the Tropics     Open Access  
Journal of Medicine Research and Development     Open Access   (Followers: 3)
Journal of Medicine, Physiology and Biophysics     Open Access   (Followers: 5)
Journal of Medicines Development Sciences     Open Access   (Followers: 1)
Journal of Metabolomics & Systems Biology     Open Access   (Followers: 2)
Journal of Mind and Medical Sciences     Open Access   (Followers: 1)
Journal of Molecular Medicine     Hybrid Journal   (Followers: 11)
Journal of Movement Disorders     Open Access   (Followers: 2)
Journal of Multidisciplinary Research in Healthcare     Open Access   (Followers: 3)
Journal of Muscle Research and Cell Motility     Hybrid Journal   (Followers: 1)
Journal of Nanotechnology in Engineering and Medicine     Full-text available via subscription   (Followers: 6)
Journal of Nanotheranostics     Open Access   (Followers: 1)
Journal of Natural Medicines     Hybrid Journal  
Journal of Natural Science, Biology and Medicine     Open Access   (Followers: 3)
Journal of Nature and Science of Medicine     Open Access   (Followers: 4)
Journal of Negative and No Positive Results     Open Access  
Journal of Nepalgunj Medical College     Open Access  
Journal of Neurocritical Care     Open Access  
Journal of Neurodegenerative Diseases     Open Access   (Followers: 2)
Journal of Neurorestoratology     Open Access  
Journal of Neuroscience and Neurological Disorders     Open Access  
Journal of Nobel Medical College     Open Access  
Journal of Obesity and Bariatrics     Open Access   (Followers: 2)
Journal of Occupational Health     Open Access  
Journal of Occupational Therapy Education     Open Access   (Followers: 12)
Journal of Ocular Biology, Diseases, and Informatics     Hybrid Journal  
Journal of Oral Biology and Craniofacial Research     Full-text available via subscription  
Journal of Oral Health and Craniofacial Science     Open Access  
Journal of Orofacial Sciences     Open Access  
Journal of Otorhinolaryngology, Hearing and Balance Medicine     Open Access   (Followers: 1)
Journal of Ovarian Research     Open Access  
Journal of Ozone Therapy     Open Access  
Journal of Palliative Medicine     Hybrid Journal   (Followers: 47)
Journal of Paramedical Sciences & Rehabilitation     Open Access  
Journal of Parkinsonism and Restless Legs Syndrome     Open Access   (Followers: 2)
Journal of Parkinson’s Disease and Alzheimer’s Disease     Open Access   (Followers: 1)
Journal of Participatory Medicine     Open Access  
Journal of Patan Academy of Health Sciences     Open Access  
Journal of Pathogens     Open Access   (Followers: 1)
Journal of Patient Experience     Open Access  
Journal of Patient Safety and Risk Management     Hybrid Journal   (Followers: 2)
Journal of Patient-Centered Research and Reviews     Open Access  
Journal of Patient-Reported Outcomes     Open Access  
Journal of Periodontal Research     Hybrid Journal  
Journal of Personalized Medicine     Open Access   (Followers: 3)
Journal of Pest Science     Hybrid Journal   (Followers: 1)
Journal of Pharmaceutical Policy and Practice     Open Access   (Followers: 4)
Journal of Physiobiochemical Metabolism     Hybrid Journal   (Followers: 2)
Journal of Physiology-Paris     Hybrid Journal   (Followers: 2)
Journal of Pioneering Medical Sciences     Open Access  
Journal of Postgraduate Medicine     Open Access  
Journal of Pregnancy     Open Access   (Followers: 4)
Journal of Prevention & Intervention Community     Hybrid Journal   (Followers: 7)
Journal of Preventive Medicine and Public Health     Open Access  
Journal of Primary Prevention     Hybrid Journal   (Followers: 7)
Journal of Prosthodontic Research     Full-text available via subscription   (Followers: 1)
Journal of Prosthodontics     Hybrid Journal   (Followers: 2)
Journal of Receptor, Ligand and Channel Research     Open Access   (Followers: 1)
Journal of Regenerative Medicine     Partially Free   (Followers: 4)
Journal of Research in Medical Sciences     Open Access   (Followers: 2)
Journal of Science and Applications : Biomedicine     Open Access   (Followers: 1)
Journal of Science and Technology (Ghana)     Open Access   (Followers: 3)
Journal of Scientific Innovation in Medicine     Open Access  
Journal of Scientific Perspectives     Open Access   (Followers: 1)
Journal of Sensory Studies     Hybrid Journal   (Followers: 4)
Journal of Shaheed Suhrawardy Medical College     Open Access  
Journal of Shoulder and Elbow Arthroplasty     Open Access  
Journal of Sleep Disorders : Treatment & Care     Hybrid Journal   (Followers: 10)
Journal of South American Earth Sciences     Hybrid Journal   (Followers: 5)
Journal of Spinal Cord Medicine     Hybrid Journal   (Followers: 5)
Journal of Spinal Disorders & Techniques     Hybrid Journal   (Followers: 2)
Journal of Sports Medicine and Allied Health Sciences : Official Journal of the Ohio Athletic Trainers Association     Open Access   (Followers: 1)
Journal of Stem Cell Therapy and Transplantation     Open Access   (Followers: 1)
Journal of Stomal Therapy Australia     Full-text available via subscription   (Followers: 1)
Journal of Strength and Conditioning Research     Hybrid Journal   (Followers: 77)
Journal of Substance Use     Hybrid Journal   (Followers: 15)
Journal of Surgical Academia     Open Access   (Followers: 1)
Journal of Surgical and Clinical Research     Open Access  
Journal of Surgical Case Reports     Open Access  
Journal of Surgical Education     Full-text available via subscription   (Followers: 3)
Journal of Surgical Technique and Case Report     Open Access  
Journal of Systemic Therapies     Full-text available via subscription   (Followers: 3)
Journal of Taibah University Medical Sciences     Open Access  
Journal of Telemedicine and Telecare     Hybrid Journal   (Followers: 12)
Journal of The Academy of Clinical Microbiologists     Open Access  
Journal of the American Association for Laboratory Animal Science     Full-text available via subscription   (Followers: 9)
Journal of the American College of Certified Wound Specialists     Hybrid Journal   (Followers: 2)
Journal of the American College of Clinical Wound Specialists     Hybrid Journal   (Followers: 2)
Journal of the American Medical Directors Association     Hybrid Journal   (Followers: 5)
Journal of the American Medical Informatics Association : JAMIA     Hybrid Journal   (Followers: 36)
Journal of the American Podiatric Medical Association     Full-text available via subscription   (Followers: 7)
Journal of the Anatomical Society of India     Full-text available via subscription  
Journal of the Anus, Rectum and Colon     Open Access  
Journal of The Arab Society for Medical Research     Open Access  

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Journal of Medical Colleges of PLA
Number of Followers: 0  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1000-1948
Published by Elsevier Homepage  [3200 journals]
  • The expressions of brain-derived neurotrophic factor and nerve growth
           factor in purified rat choroid plexus epithelial cells in vitro
    • Abstract: Publication date: October 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 5
      Author(s): Bo CHEN , Xingyu MIAO , Wei SHI , Jingnan PU , Chongxiao LIU , Zhenyu GUO , Fangru WANG
      Objective To detect the expressions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in purified rat choroid plexus epithelial cells in vitro. Methods Primary and passage choroid plexus epithelial cells were obtained from newborn, one-day Sprague-Dawley rats. The expressions of BDNF and NGF were measured by qRT-PCR and Western blottingting. The secretions of BDNF and NGF were detected by ELISA. Cell supernatants of primary cells, purified cells and passage 1 cells were harvested. Results The expression of BDNF in the purified cells was significantly lower than that in the primary cells (P<0.05), and it in the primary cells and the purified cells was significantly higher than that in the passage 1 cells (P<0.05). The expression of NGF was significantly higher in the purified cells than in the primary cells and the passage 1 cells (P<0.05). It in the passage 1 cells was significantly higher than that in the primary cells (P<0.05). Conclusion The time of CPECs transplantation for central nervous system diseases should be selected based on their secretory function and features, which could lead to better and more effective treatment.

      PubDate: 2013-12-17T22:23:18Z
       
  • Panhandle PCR strategy to amplify the upstream unknown sequence of the Pr1
           gene of pythium guiyangense
    • Abstract: Publication date: October 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 5
      Author(s): Siliang DUAN , Xiaoqing SU , Sheng YU
      Objective Based on a partialsubtilisin-like protease, Pr1 genomic sequence of Pythium guiyangense which has been cloned before, Panhandle PCR strategy was used to amplify the upstream flanking sequence adjacent to the known sequence of the Pr1 gene. Methods The genomic DNA was firstly digested with Bam H I and then treated with calf intestinal alkaline phosphatase(CIAP). Next, a 5′ phosphorylated oligonucleotide was ligated to the 5′ ends of Bam H I -digested DNA. After denaturation, intrastrand annealing and polymerase extension, a pan with a handle was formed, and lastly the nested PCR was performed. Results A 864 bp product was amplified, which was adjacent to the known sequence of Pr1 gene. The gene has been accessed by GenBank (Accession:JQ975036). Conclusion Panhandle PCR is a quick and convenient approach for amplifying and identifying unknown partner genes, which facilitates cloning full-length Pr1 gene.

      PubDate: 2013-12-17T22:23:18Z
       
  • The effect of spleen on the change of Treg cells during mouse pregnancy
    • Abstract: Publication date: October 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 5
      Author(s): Qing GAO , Mu LI , Shu ZHANG , Rui ZHOU , Jinfang WU , Zongfang LI
      Objective To analyze the effect of spleen on the Treg cells during pregnancy. Methods The mononuclear cells were separated from the peripheral, spleen and uterus or placenta blood. Flow cytometry was employed to analyze the percent of Treg cells in total T cells in different stages of pregnancy. Immunohistochemical staining was used to make sure the distribution of Treg in spleen in different stages of pregnancy. Results The results of immunohistochemical staining showed that compared with spleen Treg cells in normal unpregnant mice, spleen Treg cells on day 7 and 14 of pregnancy significantly increased. After splenectomy, peripheral blood and placenta Treg cells on day 7 of pregnancy markedly decreased as compared with the normal pregnancy (P<0.01). And the cells on day 14 of pregnancy were markedly recovered as compared with the normal pregnancy. Conclusion Our study indicated that the spleen and its Treg cells might play important roles in transient tolerance during pregnancy.

      PubDate: 2013-12-17T22:23:18Z
       
  • The effect of lipid metabolism on biological characteristics of hepatic
           stellate cell
    • Abstract: Publication date: October 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 5
      Author(s): Xinyan JING , Xuefeng YANG
      Hepatic stellate cells(HSCs) are a kind of fat-storing cells, the lipid droplets are rich in the Cytoplasm, in which retinyl ester accounts for 42%, triglyceride occupies 28%, cholesterol (total) occupies 13%, phospholipids occupies 4% respectively. Studies have confirmed that thetransforms of HSC phenotype follows the changing of the cell lipid. After the activation of HSC, with HSC phenotype changing from fat-storing cells into myofibroblast, the lipid droplets decreased or disappeared gradually, which means HSCs are under the differentiating process of removing adipose, meawhile triglyceride, and the main content of lipid droplets, also obviously reduced. It was ever declined that during the process of HSC re-fating, the activated HSC would turn into quiescent state. Therefore this shows HSCs fat metabolism is closely related to the biological activity.

      PubDate: 2013-12-17T22:23:18Z
       
  • Progress of safflower (Carthamus tinctorius L.) regeneration through
           tissue culture
    • Abstract: Publication date: October 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 5
      Author(s): Lijiao FAN , Meili GUO
      Background Safflower regeneration through tissue culture has long been limited to low frequency and lack of an efficient protocol that suitable for most safflower cultivars. In past decades, researches had been carried out to investigate safflower regeneration through tissue culture and great progress had been made. Objective To investigate factors that affect safflower regeneration through tissue culture principally. Methods This article summarized available literatures about advancements in safflower regeneration, especially discussed factors affecting safflower tissue culture in detail. Results Safflower regeneration was fairly hard than other congeneric plants, such as chrysanthemum. The genotype, seedling age, type of explants, medium components, plant growth regulators and other additives all had specific influences on safflower tissue culture. More deepgoing researches need to be undertaken to establish an effective safflower regeneration system.

      PubDate: 2013-12-17T22:23:18Z
       
  • Improving endotracheal tube tolerance with intracufflidocaine: a
           meta-analysis of randomized controlled trials
    • Abstract: Publication date: October 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 5
      Author(s): Wei CHEN , Pengling SUN , Liye YANG , Jun PU , Hongbin YUAN , Mouli TIAN
      Objective The aim of this study was to compare the efficacy in alleviating the endotracheal tube related discomfort and the safetyof intracufflidocaine (in different forms) with air and/or normal saline (NS) during general anesthesia with tracheal intubation. Methods Cochrane Central Register of Controlled Trials, PubMed and Embase were searched for relevant studies. Thirteen randomized, controlled trials involving 1 010 patients were ultimately identified. A meta-analysis of all randomized controlled trials fulfilling the predefined criteria was performed. Random-effect model and subgroup studies were used when significant heterogeneity existed among those trials. Results Compared with air and NS, intracufflidocaine could significantly alleviate the severity of sore throat at different time points (15min, 30min, 1h, 2h, 3h, 6h, 12h and 24h after extubation) and the occurrence of cough, restlessness, postoperative nausea and vomiting, dysphonia and hoarseness. Besides intracufflidocaine brought about a significant prolongation of spontaneous ventilation time. It was worth mentioning that, compared withlidocaine or its hydrochloride form, alkalinized lidocainewas much more efficient in reducing the severity of sore throat and prolonging spontaneous ventilation time. Conclusion The present meta-analysis indicates that intracufflidocaine can significantly improve endotracheal tube tolerance and this improvement can be strengthened by alkalinization of lidocaine.

      PubDate: 2013-12-17T22:23:18Z
       
  • Tumor necrosis factor-alpha mediates hyperthermia-induced glioma
           invasiveness decreases
    • Abstract: Publication date: October 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 5
      Author(s): Tian ZHANG , Yibing ZHANG , Lijuan QIN , Yuxin ZHANG
      Background Thermotherapy has already been proved effective for the treatment of various tumors, including glioma. This study was performed to determine whether tumor necrosis factor-alpha was involved in the regulation of this biological process. Methods RT-PCR and immunocytochemistry were used to investigate the levels of tumor necrosis factor-alpha mRNA and heat shock factor-1 protein, respectively, in glioma cells. Radioimmunoassay was used to dynamically monitor contents of TNF-a in nutrient fluid for C6 cells after hyperthermia treatment. Crystal violet staining method was used to detect glioma invasiveness. Results The most obvious increase of heat shock factor-1 protein and tumor necrosis factor -alpha mRNA in C6 cells were observed at 30 min and 60 min after hyperthermia, respectively. In addition, the radioactivity of tumor necrosis factor-alpha in C6 cells' culture fluid also reached peak at 120 min of hyperthermia. The glioma invasiveness decreases and the concentration of tumor necrosis factor-alpha reached the maximum at 120 min of hyperthermia. Conclusion Our results showed that the hyperthermia-mediated glioma invasiveness decreases was due to accelerated release of tumor necrosis factor-alpha, which could cause the decreases of glioma invasiveness by promoting the release heat shock factor-1 from neurospongioma cells.

      PubDate: 2013-12-17T22:23:18Z
       
  • Construction of a HERG mutant L539fs/47-*558W pEGFP vector and the
           expression of the fusion protein in HEK293 cells
    • Abstract: Publication date: August 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 4
      Author(s): Junbo ZHANG , Ying LÜ , Aifeng ZHANG , Chaofeng SUN , Wenqi HAN , Guoliang LI , Jie GAO , Jianhua HUO , Junqiang PAN , Xin ZHOU , Xiaolin NIU
      Objective To construct a human ether-a-go-go-related gene (HERG) nonsense mutant L539fs/47-*558W into the autonomously fluorescent, eukaryotic expression vector pEGFP-C2, and to verify expression of the reconstruct in human embryonic kidney-293 (HEK293) cells. Methods The mutational fragment was subcloned into pEGFP-C2-HERG by double digestion of Sbf I, Eco91 I and rejoining of T4 ligase. After verification, the recombinant pEGFP-C2-L539fs/47-*558W and pEGFP-C2-HERG were respectively transfected into HEK293 cells for 48 h by the Lipofect method to observe the expression location of the fusion protein by laser confocal imaging scanning in vivo. pcDNA3 -L539fs/47-*558W and pcDNA3-HERG were transfected to observe the expression location of the HERG protein by immunofluoresceoce. The mutant protein size was determined by Western blotting. Results The about 1 kb-sized mutation region cDNA fragment from pcDNA3-L539fs/47-*558W and the about 7.2 kb-sized target vector fragment from pcDNA3-HERG were ligated after purification and gel recovery. pEGFP-C2-L539fs/47*-558W, approximately 8.2 kb, was demonstrated successfully been constructed under agarose gel electrophoresis and further sequencing. Laser confocal imaging showed that pEGFP-C2-HERG was mainly expressed in the membrane, whereas truncated mutant-type HERG in the pEGFP-C2 vector was partially located in the cytoplasm, the others were transported to the cell membrane in living HEK293 cells. The same as the immunofluoresceoce results after transfection of pcDNA3-HERG and pcDNA3-L539fs/47-558W. Wild-type HERG-GFP fusion protein expressed 160 and 180 kDa bands. The mutant and mutant-GFP fusion proteins were 70 and 100 kDa, respectively. Conclusion pEGFP-C2-L539fs/47-*558W was successfully constructed by double digestion method GFP had no effect on its protein expression and trafficking in HEK293 cells, which laid a foundation for the further study on L539fs/47-*558W.

      PubDate: 2013-09-26T21:23:17Z
       
  • Risk factors for post-hepatectomy liver dysfunction in primary liver
           cancer patients with concurrent hepatic schistosomiasis and chronic
           hepatitis
    • Abstract: Publication date: August 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 4
      Author(s): Minfeng ZHANG , Weifeng SHEN , Wei ZHONG , Qu LIU , Rongxi SHEN , Jiamei YANG
      Objective The purpose of this study was to analyze risk factors for development of post-hepatectomy liver dysfunction in primary liver cancer (PLC) patients with concurrent hepatic schistosomiasis and chronic hepatitis. Methods A retrospective analysis of 73 PLC patients with concurrent hepatic schistosomiasis and chronic hepatitis, of which 16 patients developed liver dysfunction (persistent ascites or pleural effusion or occurrence of liver-related potentially fatal complications) following hepatectomy, was performed. After clinical characteristics were recorded, preoperative liver function parameters and surgery-related parameters in these patients were assessed. Seventeen potential risk factors for post-hepatectomy liver dysfunction were identified. The association between these potential risk factors and post-hepatectomy liver dysfunction then was analyzed. Results Univariate analysis showed that liver cirrhosis, intraoperative blood loss, and preoperative total bilirubin were associated with the development of post-hepatectomy liver dysfunction. Multivariate logistic regression analysis of these three factors revealed that intraoperative blood loss ≥600 mL and cirrhosis were two independent risk factors for post-hepatectomy liver dysfunction in PLC patients with concurrent hepatic schistosomiasis and chronic hepatitis. Conclusion Keeping intraoperative blood loss below 600 mL can help avoid the development of post-hepatectomy liver dysfunction in liver cancer patients with concurrent hepatic schistosomiasis and chronic hepatitis. For patients with concomitant liver cirrhosis, every effort should be made to minimize potential liver function impairment induced by other adverse factors.

      PubDate: 2013-09-26T21:23:17Z
       
  • Living alone, health and preventive care use among the elderly in
           Shanghai, China
    • Abstract: Publication date: August 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 4
      Author(s): Lijuan LIU , Kun SHA , Weimin REN , Yue WANG
      Objective The purpose of the study was to compare the preventive care use and health between the elderly living alone and living with other individuals and identify strategies to improve the preventive care use among the elderly living alone. Methods A questionnaire including socioeconomic characteristics, preventive care use, health status and Social Support Rate Scale was administered to 240 elderly living alone and 244 elderly living with other individuals in Shanghai, China. Lo gistic regression analysis was used to examine the predictors of preventive care use. Results The elderly living alone were more likely to be single (never married, divorced, separated and widowed), have lower social support and income, utilize less routine physical check-up and blood glucose screenings, have worse self-reported health and have limitations in IADL compared to the elderly living with other individuals. Women, old age, high education, income and social support and close to medical institutions were positively associated with routine physical check-up among the elderly. Conclusion Living alone was associated with less preventive care use and worse health. It was important to provide more social support and economic support for the elderly living alone to increase their preventive health care service utilization and improve their health status.

      PubDate: 2013-09-26T21:23:17Z
       
  • Relationship between tea dust exposure and lung function: a systemic
           literature review
    • Abstract: Publication date: August 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 4
      Author(s): Xiaobei SI , Linyu HUO , Shuo ZHANG
      Background During the production of tea, tea dust has been viewed as a risk factor that may cause the suffering of changes of lung function and respiratory symptoms. Objective To review whether the occupational exposure to tea dust may lead to the changes of lung function and respiratory symptoms. Methods We searched the literatures in March 2012 in the databases of Medline, EMBase, Web of Science, Wan-Fang Database and CNKI. The search condition is “(herb OR tea) AND (lung function OR ventilatory function OR pulmonary function OR spirometric measurement)”. The paper should be pubished in Enghish or Chinese, with internal or external controls. Results Totally 17 papers were included. Both acute and chronic changes of lung function were referred. In addition, the respiratory symptoms such as cough, tightness and etc. were also reported and discussed. Conclusion We concluded that the exposure of tea dust may lead to the changes of lung function and respiratory symptoms.

      PubDate: 2013-09-26T21:23:17Z
       
  • Who hurts who'
    • Abstract: Publication date: August 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 4
      Author(s): Wenhua YAN
      Some criminal cases happen campus in recent years. A typical case is the Fudan poison case. The case is closed, but the effect does not end. The objectives of this paper were explore: the personality profile of poison case offender; effects of poison case and to whom they hurt; how to prevent such criminal case. A ten-person focus group interview was used. Content analysis was used for data.

      PubDate: 2013-09-26T21:23:17Z
       
  • Doctor-patient communication starts from medical students
    • Abstract: Publication date: August 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 4
      Author(s): Buwei WANG
      Currently, with the increasing tensionin doctor-patient relationship and medical disputes, it is of great practical importance to train medical students' communication skills in order to establisha harmonious doctor-patient relationship to improve the quality of clinical teaching. This paper emphasizes the importance of cultivation of communication skills in medical education and suggests ways to improve communication skills among medical students.

      PubDate: 2013-09-26T21:23:17Z
       
  • Facing pressure: How should medical students or future doctors do'
    • Abstract: Publication date: August 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 4
      Author(s): Lu HAO , Deyuan ZHU , Weiye ZHU , Yan ZHANG
      On April 1st 2013, HUANG Yang, a medical master student in Fudan University, was poisoned by his roommate, LIN Senhao. Unfortunately, HUANG died 15 days later. It's quite a shock to the whole society. We have to reconsider our education, and our expectancy to doctors. We have to ask ourselves “How to become a qualified doctor'” Learn to release the pressure from studies and lives; learn to defend ourselves from danger. Is it enough' No! Whatever happened, never do harm to others. Medical humanity is the most important thing we should always remember.

      PubDate: 2013-09-26T21:23:17Z
       
  • Altered gene expression reveals molecular mechanisms underlying
           oridonin-induced apoptosis of multiple myeloma LP-1 cells
    • Abstract: Publication date: June 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 3
      Author(s): Jing ZHAO , Mei ZHANG , Pengcheng HE , Junjie ZHAO , Ying CHEN , Yuan WANG
      Objective To investigate the effect of oridonin on proliferation and invasion of human multiple myeloma LP-1 cells and the underlying mechanism. Methods LP-1 cells in culture medium in vitro were treated with oridonin at the different concentration. Cell proliferation was measured by Microwave Theory and Techniques (MTT) assay and cell apoptotic rate was detected by flow cytometry. Morphology of cell apoptosis was observed by transmission electron microscope. Expressions of Bax, Bcl-2, Caspase-3, NF-κB as well as I-κB mRNA were detected by real-time PCR. Results The MTT assays and flow cytometry revealed that oridonin could inhibit the growth of LP-1 cells and cause apoptosis significantly; the suppression was both in time-and dose-dependent manner. Marked morphological changes of cell apoptosis were found under a transmission electron microscope after the cells were treated with oridonin at 25 μmol/L for 24 h. Along with the apoptotic process, Bcl-2, Caspase-3, NF-κB gene expressions were down-regulated (P<0.05). On the contrast, the Bax and I-κB gene expressions were up-regulated (P<0.05). Conclusion Oridonin could inhibit the proliferation of LP-1 cells via inducing apoptosis. We concluded that oridonin induces apoptosis in LP-1 cells via activation of caspase-3 as well as down-regulation of Bcl-2 and up-regulation of Bax expression. The results suggested that oridonin could induce apoptosis of LP-1 cells through mitochondria- and caspase3-dependent pathways. Meanwhile, the inhibition of NF-κB and the activation of I-κB indicate pro-apoptotic stimuli. In one word, oridonin might be an important potential anti-myeloma reagent.

      PubDate: 2013-09-26T21:23:17Z
       
  • Characteristics of short double stranded RNA against hepatitis C virus: a
           literature-based analysis
    • Abstract: Publication date: June 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 3
      Author(s): Wenbin WU
      Objective To describe the characteristics of short interfering double stranded RNA (dsRNA) against hepatitis C virus (HCV) and to find out the determining factors in design for desirable inhibitory efficacy. Methods The data were collected and analyzed by retrieval of 229 published short dsRNAs designed for degradation of HCV RNA. Results Statistical analyses showed that the most frequently involved short dsRNAs were directing against 5'NTR/core and genotype 1b, accounting for 64.2% and 69.9%, respectively. Inhibitory efficacy varied with the structural characteristics of short dsRNAs, of which the most potential were those directed against HCV core region with inhibitory efficacy of 70.2%. Moreover, the mean inhibitory efficacy of short dsRNAs with GC contents from 30% to 52% was higher than that of those with GC contents out of this range. Conclusion Based on this pooled data in a relatively large sample, the present results provided clues to design for short dsRNAs with more potent inhibitory efficacy.

      PubDate: 2013-09-26T21:23:17Z
       
  • Serum level of galectin-3 and its clinical significance in patients with
           chronic Keshan disease
    • Abstract: Publication date: June 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 3
      Author(s): Yuxiao SUN , Xin LIU , Dengfeng GAO , Xin DONG , Canzhan ZHU , Zhenhua HAN , Yiqiang YUAN , Yanhe ZHU , Xiaolin NIU
      Objective Keshan disease (KD) is a fatal endemic dilated cardiomyopathy with unclear etiology and pathogenesis, and a high mortality in China. Pathologic studies confirmed that different degree of myocardial fibrosis existed in various types of KD. Myocardial fibrosis is an important contributor to the pathophysiology of left ventricular remodeling. Recently, galectin-3 (Gal-3) as a marker of cardiac fibrosis and heart failure was approved by the US FDA. The aim of this study was to evaluate the changes of serum level of Gal-3 in chronic KD (CKD) and their clinical implications. Methods The levels of serum Gal-3 were measured by using enzyme-linked immunosorbent assay (ELISA) in 37 CKD patients and 32 healthy controls. Echocardiography was used to determine parameter of left ventricular ejection fraction (LVEF) and left ventricular end-diastolic dimension (LVEDD). Results The serum concentration of Gal-3 ([95.81±18.99] ng/ml versus [48.16±11.09] ng/ml, t=6.906, P<0.001) and LVEDD ([60.46±7.63] mm versus (42.69±10.66) mm, t=3.61, P<0.01) were significantly higher, while LVEF ([42.69±10.66]% versus [62.16±6.38]%, t=4.679, P<0.01) were significantly lower in CKD patients compared with healthy controls. A negative correlation was found between elevated Gal-3 and lower LVEF (r=−0.882, P<0.001) and a positive correlation was found between elevated Gal-3 levels and enlarged LVEDD (r=0.834, P<0.001) or higher NYHA class (r=0.854, P<0.01) in CKD patients. Conclusion Serum concentration of Gal-3 is strongly correlated with poorer left ventricular systolic function, enlarged LVEDD and higher New York Heart Association (NYHA) class, which may provide indirectly diagnostic information on myocardial fibrosis and heart function in CKD patients.

      PubDate: 2013-09-26T21:23:17Z
       
  • The pain-related behavior changes correlate with the bone damage in a rat
           model of rheumatoid arthritis
    • Abstract: Publication date: June 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 3
      Author(s): Shicheng ZHENG , Kunzheng WANG , Lihong FAN , Zhibin SHI , Junchang CHEN , Hongxiang BAO
      Objective In view of the extensive bone damage in rheumatoid arthritis, we used a commonly utilized animal model to detect behavioral changes in pain-related and the bone damage during the early disease, and to explore the correlation between bone damage and pain-related behavioral changes. Methods Arthritis were induced in Sprague-Dawley (SD) male rats by injecting complete Freund's adjuvant (CFA) into the tails. Pain-related behavior changes were studied using the Hargreaves, VonFrey, and acetone tests on the 0, 7, 14, day and 28 day after CFA injection. The rats were sacrificed according the same schedule. The bone damage of the right proximal tibia was studied by microCT scan and bone histological slices. Results Animals developed soft tissue inflammation and polyarthritis on 7 days after CFA injection, and arthritic score proved obvious arthritis were established within the study period. Mechanical hyperalgesia and cold allodynia were present in the affected hind paw from the 7 day through the 28 day, but the heat hyperalgesia and the mechanical allodynia lasted a short time after CFA injection. Trabecular bone number (Tb.N), Tissue Mineral Content (TMC) and Bone Volume to Tissue Volume (BV/TV) in the proximal tibia by microCT scan were also reduced after induction, especial 14 days after CFA injection. The bone histological slices showed the trabecular bone and proteoglycan diminished, the bone damage severity scores became more severely on the 7 day after CFA injection. Using analysis of covariance, these changes had statistical significance compared with baseline. By linear regression analysis demonstrated mechanical hyperalgesia and cold allodynia correlated well with arthritic score, bone damage parameters and bone damage severity scores. Conclusion Adjuvant-induced arthritis (AA) were observed after CFA injection and lasted within the later experimental period. Pain-related behavioral changes were observed in the early time of AA. Bone damage was also occurred with arthritis development. Pain-related behavioral change correlated well with arthritic score and bone damage parameters.

      PubDate: 2013-09-26T21:23:17Z
       
  • Etiological study of benign esophageal dysphagia with only
           granulation-report of two cases and litertature review
    • Abstract: Publication date: June 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 3
      Author(s): Rui GAO , Yina JIANG , Junke FU , Guangjian ZHANG
      Etiologies of benign esophageal dysphagia are diverse and a panel of clinical and laboratory investigations should be taken to make the right diagnosis. We report herein two cases of benign esophageal dysphagia of non-infectious origin. Imaging tests identified changes similar to malignancies, while only inflamed granulation tissue was discovered in biopsy specimens. Surgical resection was finally applied due to severe symptoms and the histological study revealed only granulation tissue. They were diagnosed as idiopathic cases when all the known non-infectious pathogenesis were carefully ruled out by sound examination results. The differetail diagnosis of benign esophageal dysphagia is quite important as observational data shows that medical therapy should be applied in certain pathogenesis, while esophagectomy might be the most effective solution for other etiologies. Subsequently a comparison of the manifestations of the two cases and those of esophageal dysphagia induced by other non-infectious etiologies was done to shine some light on the differencial diagnosis of benign esophageal dysphagia.

      PubDate: 2013-09-26T21:23:17Z
       
  • Endoscopic trans-minor papilla biliary drainage: a case report
    • Abstract: Publication date: June 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 3
      Author(s): Yamin PAN , Jun WU , Tiantian WANG , Bing HU
      In normal physiological anatomy, common bile duct opens in the major papilla and does not communicate with the minor papilla directly. There is little chance to cannulate biliary system via the minor papilla. There was no report of trans-minor papilla biliary drainage in the literature. We presented a case with malignant obstructive jaundice that underwent trans-minor papilla biliary drainage. A 5F super slim nasobiliary tube was inserted into common bile duct successfully through minor papilla during endoscopic retrograde cholangio-pancreatography (ERCP). The patient did not complain abdominal pain or any discomfort after procedure. Biliary drainage was effective (500-800 ml per day). The patient's jaundice relieved significantly during follow-up.

      PubDate: 2013-09-26T21:23:17Z
       
  • Nursing of adverse effects in patients treated with liver resection plus
           sorafenib for hepatocellular carcinoma: 5 cases report
    • Abstract: Publication date: June 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 3
      Author(s): Hongling WANG , Jing LI , Xueqing SHAO
      There were very few reports of adverse effects in patients treated by liver resection in combination with sorafenib. We present 5 cases of hepatocellular carcinoma treated with liver resection plus sorafenib, trying to observing the adverse effects and seeking the nursing options to the adverse effects. The 5 patients were all males, and the mean age was (38.6±13.4) years. Tumor sizes were (6.7±2.2) cm, and liver function was Child-Pugh class A. Diagnosis of Hepatocellular carcinoma (HCC) was confirmed by postoperative pathology. During the follow-ups, all the 5 patients had different degrees of adverse effects, of which 5 patients had diarrhea, 3 had hand-foot skin reaction, 1 had hypertension and 1 had alopecie. Diarrhea seems common in these patients, and it appeared early after treatment. For those patients with adverse effects, management measures were given immediately, including nursing interventions and some medicines. Psychological and symptomatic nursing guidance can help patients overcome the adverse effects. No patients suffered dose reduction or treatment discontinuation.

      PubDate: 2013-09-26T21:23:17Z
       
  • Lactulose mediates suppression of dextran sulfate sodium-induced colon
           inflammation
    • Abstract: Publication date: April 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 2
      Author(s): Yuedong HAI , Yu HONG , Qi WANG , Xudong LIU , Dexi LI
      Objective Assessment of digestion colonic flora lactulose can be induced to produce hydrogen and prove lactulose with a potential anti-inflammatory effects. Methods We established a mouse model of human ulcerative colitis (UC) by supplying mice with water containing dextran sulfate sodium (DSS). At 7-day, DSS-induced pathogenic outcomes, including loss of body weight, increase of colitis score, pathogenic shortening of colon length, elevated level of TNF-α, IL-1β, malondialdehyde (MDA) and myeloperoxidase (MPO) deficiency in colon lesions, were significantly suppressed by lactulose administration and intraperitoneally injected hydrogen water. Results After eliminating colon microflora by antibiotics, the anti-inflammatory effects of lactulose were significantly compromised. Histological analysis also revealed that the DSS mediated colonic tissue destruction accompanied by neutrophils infiltration was remarkably suppressed by lactulose and hydrogen water. Conclusion The present study indicated that lactulose can prevent the development of DSS-induced colitis and alleviate oxidative stress state in colitis.

      PubDate: 2013-05-26T06:28:56Z
       
  • Changes of bone mineral in steroid-induced osteonecrosis in rabbits
    • Abstract: Publication date: April 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 2
      Author(s): Tao WANG , Kunzheng WANG , Lei WANG , Jian GUO , Ying GAO , Zengtie ZHANG , Liaosha JIN , Chunsheng WANG , Wei WANG
      Objective To investigate the significance of bone mineral changes in the pathogenic process of steroid-induced osteonecrosis in rabbits. Methods Seventy adult female Japanese White rabbits were randomly divided into five groups. Animals in steroid group received an intramuscular injection of methylprednisolone acetate (4 mg/kg) once a week, and killed in four different time after first treatment. Animals in control group received an intramuscular injection with the same volume of normal saline, while 150 kU penicillin was injected twice a week for preventing infection in all groups. The contents of serum calcium (Ca) and phosphorus (P) were determined and the bone mineral densities of the femoral head and neck were measured at the 2nd, 4th, 8th and 10th weeks after first treatment. Meanwhile the general condition such as weight, spirit and hair of rabbits was observed. Results Compared with the control group, the weight of rabbits in steroid group lost since the first week, and progressively aggravated; the bone mineral density of the femoral head and neck was lowered since the 2nd and 4th week respectively (P<0.05, P<0.01), and lowered more quickly in femoral neck than in femoral head. In steroid group, the bone mineral density of the femoral neck at the 10th week was significantly lower than that at the 8th week (P<0.05). Compared with the control group, the serum levels of Ca and P in steroid group were lowered since the 2nd week (P<0.05, P<0.01). In steroid group, the serum Ca level at the 10th week was lower than that at the 8th week, and the serum P level was lowered more quickly than Ca level was. Conclusion Osteonecrosis appears in rabbits shortly after corticoids are first administered, and osteonecrosis in rabbits is chronologically associated with the onset of hypocalcaemia, hypophosphatemia and lowered bone mineral density. Steroid-induced osteonecrosis may be relevant to bone mineral loss and density lowering of the femoral head and neck.

      PubDate: 2013-05-26T06:28:56Z
       
  • The diagnosis of hyperkalemia induced by potassium chloride in
           experimental rabbits
    • Abstract: Publication date: April 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 2
      Author(s): Hong LIU , Qiaoling FENG , Wei ZHANG , Yongjun XIE , Xingguo LIU
      Objective To observe the electrocardiogram (ECG) and heart rate in a rabbit model of hyperkalemia induced by potassium chloride, and provide theoretical and experimental reference for timely diagnosis of hyperkalemia clinically. Methods Forty rabbits were randomly assigned into four groups. 0.9% isotonic saline solution was perfused in the group I, while l.0%, 4.0% and 10.0% potassium chloride solutions were perfused in the other groups, respectively, to induce hyperkalemia. Results The changes of serum potassium, ECG and heart rate before perfusion were significantly (P<0.05) different from those after perfusion in the other groups compared with group I. The effect of ECG variability rates was well consistent (Kappa = 0.724, P<0.01) with that of serum potassium on diagnostic tests in the other groups. The area under ROC curve in diagnosis effect of ECG variability rates and serum potassium on hyperkalaemia was much significantly larger (P<0.01 and P<0.05) compared with 0.5. There was a significantly positive correlation between ECG variability rates and serum potassium (r= 0.865, P<0.05 for bilateral Pearson test). There was certain positive correlation between heart rate and serum potassium, but the correlation was poor (r= 0.526, R 2=0.277). Conclusion A combination of serum potassium, ECG variability rates and heart rate should be considered and analyzed by synthesis to establish an accurate and timely diagnosis for hyperkalemia.

      PubDate: 2013-05-26T06:28:56Z
       
  • Design of portable and intelligent infuser device for rapid fluid
           transfusion based on micro-electro-mechanical system
    • Abstract: Publication date: April 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 2
      Author(s): Qing WANG , Yinbao CHONG , An ZHAO , Jiuling LIU
      Objective A novel portable and intelligent fluid resuscitation infuser is proposed in this paper. It satisfies the demands of long time use in harsh environment, such as traffic accident, natural disaster, battlefield, evacuation, pre-hospital emergency and so on. Methods Miniature linear motor and liquid blood cartridge compose the pump body. It's based on the biological impedance method to measure and control, which resolve the disadvantage of traditional infuser devi large power dissipation, big size, AC power supply only and can't be use in field. The whole device weights 250 gram and sizes as two mobile phone together. Results Model device experiment shows: six number 7 standard AAA size alkaline batteries will run the pump for approximately 8–10 h at 6 liters per hour; IV bag can be placed at any position of patient, even under the stretcher. Conclusion It provides accurate and reliable intravenous infusion for first-aid treatment in field.

      PubDate: 2013-05-26T06:28:56Z
       
  • Surgery and follow-up care for auricular keloid: a report of 156 cases
    • Abstract: Publication date: April 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 2
      Author(s): Liang CHEN , Chuan CAO , Xiaoge LI , Dongyun YANG , LI Shirong
      Objective To treat and prevent auricular keloid so as to imporve the cure rate and lower the rate of recurrence. Methods Taking 156 sufferers of auriclar keloid at the orthopaedics department of the Southwest Hospital under the Third Military Medical University from June, 2008 to June, 2011 as the research subject, this research carried out retrospective analysis and summary of different surgical methods with the clinical data of subsequent treatments, including medicament, radiotheropy, pressure, etc. Results There was no auricular cartilage necrosis and deformation in the total of 156 cases. It was found that 134 cases were cured in a year of postoperative follow-up, getting the care rate to 85.9%. The treatment was effective on 20 cases, with the effective rate of 12.8%, while it was ineffective on 2 cases, with the ineffective rate being 1.3%. However, two cases showed tendency towards recurrence, which were treated effectively by non-surgical methods like local hormone injection. There was neither recurrence nor apparent hyperplasia of hypertrophic scars on the rest cases, with the auricle and the earlobe in good shape. Conclusion By auricular keloid excision and stripping surgery, surgical suture tension was reduced. Glucocorticoid and radiotherapy were instantly applied to inhibit pyperplasia of cicatrical tissue. Subsequently, pressure, anti-scarring drugs and silicone membrane were adopted to ensure fine postoperative apperance and reduce recurrence. These methods were proved to be effective and they provided systematic and effective treatment for auricular keloid.

      PubDate: 2013-05-26T06:28:56Z
       
  • Heparin-induced thrombocytopenia associated with pulmonary embolism after
           total knee arthroplasty: a case report and review of literatures
    • Abstract: Publication date: April 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 2
      Author(s): Hengfeng YUAN , Weidong XU
      Type II heparin-induced thrombocytopenia (HIT) is a life-threatening adverse drug reaction initiated by heparin administration. We described a rare case of LMWH-induced HIT complicated with proven pulmonary embolism (PE) in a 75-year-old male patient who hospitalized with diagnose of right knee osteoarthritis and was underwent total knee arthroplasty. The patient was successfully treated with argatroban. Early recognition and timely alternative therapy are of great importance in the treatment of this severe disorder.

      PubDate: 2013-05-26T06:28:56Z
       
  • An epidemic of violence on medical personnel: are we prepared
    • Abstract: Publication date: April 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 2
      Author(s): Han ZHANG , Yan ZHANG
      The incidence of violence against doctors has been increasing, both in China and worldwide. Very often we hear doctors being molested, thrashed and abused by lay public for a trivial medical malpractice or even no fault of theirs. The once glittering halo of medical workers is being shredded thanks to the stressed health system and a lack of evaluation for risk of violence of the patients. Modern China sees a wide disparity between industry standards in rural and urban areas. People seeking health care service are often scared, can't get timely service and turn their anger towards those around them. To change a whole system in this giant nation is too hard a rock. Therefore, our focus is on the prompt awareness and preparation of a possible patient violence. The simplest approaches seem to be the most effective. Medical staffs should re-learn empathy on patients and be better trained on recognizing and reducing conflicts.

      PubDate: 2013-05-26T06:28:56Z
       
  • Humanistic caring: the core of nursing
    • Abstract: Publication date: April 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 2
      Author(s): Qiuting CAO
      The voice of calling for humanistic concern is always from uncountable doctor-patient conflicts, from which we often hear a doctor is killed or injured for disputes. Prejudice has been rooted in mind that all doctors and nurses are interest-centered and cold-blooded. To some extent, it's true that patterned questions with a poker face are always more than gentle words with warm smile. Nurses are the ones who keep patients company for the longest time. Therefore, caring matters more for them. The explicit concept of “caring” will be introduced and we will attach great importance to how nurses can achieve caring. From the following aspects: the practices of loving kindness, the instillation of faith and hope, sensitivity to indicators of disease, improvement of healing environment, communication arts etc, you will understand why nurse is the symbol of angel. We can begin with caring about people around us. Our duty is not only to deal the ill but to warm the chill.

      PubDate: 2013-05-26T06:28:56Z
       
  • English forum on medical humanity for medical students in China —
           Interviews with President SUN Yinghao and Professor HU Jiyue, SMMU
    • Abstract: February 2013
      Publication year: 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 1



      PubDate: 2013-03-18T03:09:48Z
       
  • English Forum on Medical Humanities of SMMU: An interdisciplinary
           innovative teaching practice
    • Abstract: February 2013
      Publication year: 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 1

      To conform to the college English teaching reform from English for General Purposes (EGP) to English for Academic Purposes (EAP) in the vital transfer era, the Foreign Language Department of Second Military Medical University (SMMU) launched an English for Medical Academic Purpose (EMAP) curriculum with English Forum on Medical Humanities (EFMH), a project-based teaching practice. Based on Rogers' learner-centered humanistic teaching approach which emphasizes students' involvement and experiences in learning, EFMH puts students and their practice in a central place. After four-year exploration and operation, the Forum has developed from a small-scaled embryo into an internationalized, standardized and professionalized event, having produced fruitful outcomes. It is expected that the success of EFMH will provide inspiring experiences and enlightenments for higher medical education in terms of academic English teaching and teachers' responsibilities to foster high-quality medical students.

      PubDate: 2013-03-18T03:09:48Z
       
  • The blossom of “the rose of surgery” — The birth of
           heart-lung machine
    • Abstract: February 2013
      Publication year: 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 1

      The development of the heart-lung machine made repair of intracardiac lesions possible. One of the key requirements of the heart-lung machine was anticoagulation. Heparin was discovered by a medical student, Jay McLean, working in the laboratory of Dr. William Howell at Johns Hopkins. John Gibbon contributed more to the successful development of the heart-lung machine than anyone else. His interest began as a young doctor since 1930s. Gibbon's work on the heart-lung machine took place over the next 20 years in laboratories at Massachusetts General Hospital, the University of Pennsylvania, and Thomas Jefferson University. In 1937, he reported the first successful demonstration that life could be maintained by an artificial heart and lung, and the native heart and lungs could resume function. After World War II, Dr. Gibbon resumed his work and received support from IBM to build a heart-lung machine on a more sophisticated scale. Eventually, the team developed a larger oxygenator that the IBM engineers incorporated into a new machine. On May 6, 1953, Dr. Gibbon performed the first successful operation using an extracorporeal circuit on an 18-year-old girl with a large atrial septa1 defect. It wasn't until 1958, when a system that involved bubbling blood was perfected, that “heart-lung” machines came of age. Despite so many chill winds and cold rains, “heart-lung” machine, the budding rose of surgery, was eventually blossom brightly in the radiant rays of sunlight. John Gibbon's dream had become a reality. His work serves as an important example to surgeons who are struggling today with the surgical therapies and technologies of tomorrow.

      PubDate: 2013-03-18T03:09:48Z
       
  • Research on psychological factors which influence Doctor-Patient
           communications among outpatients
    • Abstract: February 2013
      Publication year: 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 1

      An Outpatient Department is the first point of contact with the hospital, and good Doctor-Patient communication would improve the service quality of the hospital, so it is important to construct a harmonious Doctor-Patient relationship. This article, from the perspective of psychology, investigates into the common psychological factors which affect the Doctor-Patient communication, the appearance of the communication problem, and make suggestions on possible solutions accordingly.

      PubDate: 2013-03-18T03:09:48Z
       
  • Humanity factors and more: A little heads up for medical students and
           future doctors
    • Abstract: February 2013
      Publication year: 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 1

      Exactly how can we become a successful doctor in the future? It has been widely accepted that chasing perfection in our field of expertise alone is not enough. Here in China, doctors have the liability to do more. Chinese doctors are relatively more prone to confronting difficult situations in a more complex manner. Therefore, the humanity factor in medical practice is discussed, and some essential communication skills are suggested for medical practitioners, with heartfelt anticipation for a better medical environment as well as a more pleasant Doctor-Patient relationship.

      PubDate: 2013-03-18T03:09:48Z
       
  • Continuous sedation until death: Therapeutically and ethically acceptable
    • Abstract: February 2013
      Publication year: 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 1

      If a patient is dying and still suffering great pain, what is the least harmful alternative? Here we prefer continuous sedation until death (CSD). CSD differs from physician-assisted death (PAD) in many aspects. Firstly, CSD is not used to shorten life or cause death, but instead its intention is to relieve suffering. Secondly, once CSD is associated with a reduction in or suspension of food intake, the duration of sedation is too short to have an impact on survival rate. Thirdly, CSD is titrated while PAD is often overdosed. Fourthly, the sanctity of life could be maintained since sedation is used merely as a means of quelling suffering. Last but no least, for unconscious patients, the same medicines are frequently used for both palliative sedation and standard surgical procedures.

      PubDate: 2013-03-18T03:09:48Z
       
  • Doctors' faith
    • Abstract: February 2013
      Publication year: 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 1

      We make some efforts to find some connections between religion and medical science. Medical science can be regarded as sacred and holy as a religion for doctors to believe. The common points between them are the basis to successfully integrate them into doctors' faith. Furthermore, we explain that doctors need a faith to believe so as to meet the demand of humanitarian traits we should have and to do better in the scientific work and win in the battles with the diseases.

      PubDate: 2013-03-18T03:09:48Z
       
  • How to lead foreign students into Traditional Chinese Medicine
    • Abstract: February 2013
      Publication year: 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 1

      Traditional Chinese Medicine (TCM) is becoming much more international and widely accepted. More and more foreign students come to mainland China to study this great yet mysterious discipline. However, the current teaching methods are far from satisfaction. This paper analyzes some existing problems and contradictions present in the teaching practices and suggests some measures for improvement.

      PubDate: 2013-03-18T03:09:48Z
       
  • Investigations and thoughts of the ethics in genetic discrimination
    • Abstract: February 2013
      Publication year: 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 1

      A questionnaire research in ethics was conducted to get the view of students of medical universities in Shanghai on genomics and genetic discrimination. We find that 66% respondents indicated their willingness to understand the genetic information and 79% of respondents mind their own genetic information be aware of by other people. In contrast, 77% of the respondents believe that medical organization are not able to protect personal genetic information from disclose. Hence, it is significant to take some measures to preserve citizen's genetic information privacy. Depending on our results, we put forward our suggestion to this problem.

      PubDate: 2013-03-18T03:09:48Z
       
  • Ethnomedicine: fading or flowering? — Heritage and development
           of Dai Medicine
    • Abstract: February 2013
      Publication year: 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 1

      Ethnomedicine is an important component of ethnic culture, and a part of traditional medicine in China. We undertook great considerations and in-depth investigations of Dai Medicine, as well as analyses of its basic concepts, current situations, and interrelations with Traditional Chinese Medicine. The issues regarding Dai Medicine's heritage and development are also discussed.

      PubDate: 2013-03-18T03:09:48Z
       
  • A genre analysis of medical abstracts by Chinese and English native
           speakers
    • Abstract: February 2013
      Publication year: 2013
      Source:Journal of Medical Colleges of PLA, Volume 28, Issue 1

      This study presents statistical results of a comparison between English abstracts in a leading international medical journal and those in a Chinese one. With a genre analysis and discussion of linguistic features of these abstracts, the paper points out the weak points in the abstracts by Chinese writers and provides some suggestions for writing abstracts of medical research articles.

      PubDate: 2013-03-18T03:09:48Z
       
  • Different morphologic features of rat cochlea progenitor spheres and their
           implications
    • Abstract: December 2012
      Publication year: 2012
      Source:Journal of Medical Colleges of PLA, Volume 27, Issue 6

      Objective To detect the different morphologic features, developmental regulation, potential of proliferation and differentiation of neonatal rat cochlea progenitor spheres. Methods We isolated the cochlea sensory epithelium cells from neonatal rats and cultured them in nonadherent conditions to acquire different morphologic spheres. Then we observed the diameter and compositional change of cell colonies in distinct sphere types on day 3, 6, 9 and 12, and summarized the regularity of development and their conversion. We also detected the proliferative activity of distinct spheres by immunohistochemical staining of Abcg2, Nestin and BrdU. After induced spontaneous differentiation, the spheres were detected in the changes of the marker of hair cell, MyosinVIIA; by immunocytochemical staining, we revealed the potential of how different spheres were converted into hair cell-like cells. Results The acquired three types of suspended spheres are solid, transitional, and hollow. There's morphologic significance among them and they can covert into the other type of spheres among them. The ability of self-renewing and proliferation in distinct spheres vary and all of them have the potential of spontaneously differentiation into hair cell-like cells. Conclusion All the type of spheres not only has the potential of proliferation and differentiation, but also has the potential of spontaneous differentiation into hair cell-like cells. Distinct types of cell spheres neither originate from different progenitor cell subcolonies nor are different stages of the same cell spheres. Solid spheres are most practically useful.

      PubDate: 2013-02-12T23:58:22Z
       
  • Tamsulosin as medical expulsive therapy for lower ureterolithiasis: A
           meta-analysis
    • Abstract: December 2012
      Publication year: 2012
      Source:Journal of Medical Colleges of PLA, Volume 27, Issue 6

      Objective To review the evidence for tamsulosin as medical expulsive therapy in enhancing the effectiveness of distal ureteral stone clearance rate. Methods We searched Pubmed/Medline, Embase, CBM and the Cochrane Library up to October 2011. All randomized controlled trials in which tamsulosin was evaluated with distal ureterolithiasis were eligible for the analysis. Outcome measure assessed was stone clearance rate. Two authors independently assessed study quality and extracted data. All data were analyzed using RevMan 5.1. Results Thirteen studies involving 1067 participants met the inclusion criteria. Study duration ranged from 7 to 42 d. The pooled analysis showed an improvement of 41% in stone clearance rate of tamsulosin as medical expulsive therapy for distal ureteral calculi (RR=1.41, 95% CI=1.18 to 1.70). According to stone size (6 mm
      PubDate: 2013-02-12T23:58:22Z
       
  • Low polar volatile constituents from Isodon excisa by GC-MS
    • Abstract: December 2012
      Publication year: 2012
      Source:Journal of Medical Colleges of PLA, Volume 27, Issue 6

      An attempt had been made to isolate and identify the low polar volatile constituents from Isodon excisa. The dried plants were heat extracted with ethanol and then extracted with petroleum ether. The constituents were isolated and analyzed by GC-MS and then we retrieved them on NIST08 mass spectrometry database to determine their structures. Finally, successful results were achieved, 111 compounds were obtained and identified. 105 of them were reported for the first time in Isodon excisa and 22 of them were first found in natural products. Thus, the main constituents of it were found to be Sitosterol (33.28%), 3-Amino-4-pyrazolecarbonitrile (9.55%).

      PubDate: 2013-02-12T23:58:22Z
       
  • Current status of medical support in military operations other than war in
           domestic and overseas
    • Abstract: December 2012
      Publication year: 2012
      Source:Journal of Medical Colleges of PLA, Volume 27, Issue 6

      Objective To investigate the current status of medical support in military operations other than war (MOOTW) in domestic and overseas. Methods This paper mainly adopts the descriptive, comparative and induction research methods. The current status of medical support in MOOTW in China, America, Russia, Israel, Canada, had been studied through some official papers, and series of professional books by analysis the precise date in various kinds of emergency event. Results The contrast shows that there is still a quite huge development in medical support in MOOTW, no matter in China, or in other countries. Conclusion In order to strengthen the forces, besides building professional rescue teams, it is necessary to take a regular revise of plans, according to missions' needs.

      PubDate: 2013-02-12T23:58:22Z
       
  • Health care of elderly military veteran cadres
    • Abstract: December 2012
      Publication year: 2012
      Source:Journal of Medical Colleges of PLA, Volume 27, Issue 6

      With the development of our economy and the improvement of people's living standard, the person's life span has been greatly prolonged. Accordingly, there are more and more requirements on health care. The retired cadres in military sanatoriums are heroes in the revolution of our country, and are treasures to our country. However, with the increase of their age, various kinds of diseases have become the main problem bothering the cadres. At present, our party and government are very concerned about veteran cadres. Hence, the medical workers are facing a new problem and challenge as to how to prevent the diseases and improve the medical treatment, and health care for military veteran cadres. We insist on “the people-oriented service and treatment” and try hard to improve service on “prevention, medical care, rehabilitation, and health care”. In this way, they may suffer from less pain of diseases, have better prognosis, enjoy happier life, and their disease prevalence and mortality may be lower.

      PubDate: 2013-02-12T23:58:22Z
       
  • Health care exploration work for the military empty nest old cadres
    • Abstract: December 2012
      Publication year: 2012
      Source:Journal of Medical Colleges of PLA, Volume 27, Issue 6

      In recent years, the retired veteran cadres have grown older and older, and their numbers have also increased year by year. In this case, how to maintain the physical and mental health of empty nest veteran cadre, and further improve the quality of their life has been a realistic problem many primary health care doctors have to face and solve.

      PubDate: 2013-02-12T23:58:22Z
       
  • Mental health service to military retired cadres
    • Abstract: December 2012
      Publication year: 2012
      Source:Journal of Medical Colleges of PLA, Volume 27, Issue 6

      Military retired cadres were commonly in aged period with high-incidence of diseases. They were troubled with senility, illness, empty-nest syndrome and spouse-bereft, so they were more vulnerable to some psychological problems. Therefore, promoting the mental health service for retired cadres should be highly concerned and more professional service work should be provided to them.

      PubDate: 2013-02-12T23:58:22Z
       
  • Effects of angiotensin-II receptor blockers on β-catenin expression in a
           rat model of experimental streptozotocin-induced early-stage of diabetic
           nephropathy
    • Abstract: October 2012
      Publication year: 2012
      Source:Journal of Medical Colleges of PLA, Volume 27, Issue 5

      Objective Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. The pathogenesis of progressive renal injury is multifactorial and the mechanism by which hyperglycemia causes microangiopathy is still poorly understood. The WNT pathway is activated in DN and regulating β-catenin protein levels is referred to as the canonical Wnt/β-catenin pathway. Because the renin angiotensin system has been reported to be an important contributory factor in the pathophysiology of DN, exogenous administration of angiotensin II receptor antagonist may be beneficial in counteracting some biochemical or functional changes of DN. The aim of the study was to determine the β-catenin expression and the possible protective effects of irbesartan, an angiotensin II type 1 receptor blocker (ARB) in a rat model of streptozotocin(STZ)-induced diabetic nephropathy. Methods STZ-induced DN in rats was assessed biochemically by measuring urine volume, protein and creatinine clearance as well as Kidney weight/body weight (KW/BW) and the index of mesangial expansion. Three groups of male Sprague-dawley rats were used. The first group consisted of non-diabetic control rats (control). The second group was the untreated diabetic rats(STZ+vehicle). The third group consisted of diabeti rats treated with irbesartan, 50 mg/kg for 12 weeks (STZ+irbesartan). Immunohistochemical stainings and real time PCR for β-catenin were performed in renal cortex of rat modals. Results Marked hyperglycemia, polyuria, proteinuria, renal hypertrophy, mesangial matrix expansion and glomerular hyperfiltration were observed in STZ diabetic rats. The levels of microalbuminuria and KW/BW in the STZ+irbesartan group were lower than those in the STZ+vehicle group (P
      PubDate: 2012-12-17T07:06:10Z
       
  • Effect of statins use on the prevention of venous thromboembolism: a
           meta-analysis
    • Abstract: October 2012
      Publication year: 2012
      Source:Journal of Medical Colleges of PLA, Volume 27, Issue 5

      Objective To estimate the effect of statins use on the prevention of venous thromboembolism (VTE). Methods We systematically searched MEDLINE (1980-June 2012), EMBASE (1980-June 2012), Google Scholar, Cochrane Library, and ISI Web of Science, manually reviewed references, and contacted experts. Case-control studies and cohort studies that compared any dose of statin with no statin or placebo are included. Data extraction and study quality evaluation were independently conducted in duplicate. Results 12 studies including four cohort studies and eight case-control studies were identified and eligible for meta-analysis. Upon meta-analysis, statin use was associated with a statistically significant reduction in the odds of developing VTE (OR 0.91, 95% CI 0.86–0.96). Conclusion This meta-analysis of current and available literature suggests that statins can reduce patient's risk of developing VTE. Due to the limitations of observational study, this conclusion should be considered with caution, and additionally, specifical well-designed trials are needed.

      PubDate: 2012-12-17T07:06:10Z
       
  • Octreotide inhibits proliferation and invasion of MHCC97-H cells in vitro
           and in vivo
    • Abstract: October 2012
      Publication year: 2012
      Source:Journal of Medical Colleges of PLA, Volume 27, Issue 5

      Objective To figure out the effect of somatostatin analogue Octreotide on proliferation and invasion of human hepatocellular carcinoma cell MHCC97-H and the underlying mechanism in vitro and in vivo. Methods MHCC97-H cells were treated with Octreotide at the concentration of 0.2 ug/mL in vitro, proliferation related to time was evaluated. After treated with Octreotide at the concentration of 0.2 ug/mL for 48 h, MHCC97-H cells were observed by transmission electron microscope. Cell proliferation was detected by MTT assay after MHCC97-H cells were treated with Octreotide at different concentrations including 0.05, 0.1, 0.2, 0.4, 0.6 and 0.8 ug/mL for 36 h in vitro. 27 nude mice, in which MHCC97-H tumor mass was planted orthotopically, were divided into 3 groups randomly including control group (intraperitoneal injection with equal volume normal saline; n=8), low dose treated group (intraperitoneal injection with Octreotide at 50 ug/kg·d; n=9) and large dose treated group (intraperitoneal injection with Octreotide at 200 ug/kg·d; n=10). All mice were raised for 35 d and sacrificed. The information about survival time, the weight at death point and the pathology change of liver and lung was collected. The expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinases-2 (MMP-2) in mouse HCC tissues were detected by immunohistochemistry finally. Results MTT assays showed that Octreotide inhibited the proliferation of MHCC97-H cells significantly. Apoptosis cells were found by transmission electron microscope after treatment with Octreotide at 0.2 ug/mL for 48 h in vitro. The proliferation was inhibited significantly by Octreotide in a dose-dependant manner (r=0.86, P
      PubDate: 2012-12-17T07:06:10Z
       
 
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