Subjects -> MEDICAL SCIENCES (Total: 8690 journals)
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MEDICAL SCIENCES (2415 journals)            First | 3 4 5 6 7 8 9 10 | Last

Showing 1201 - 1400 of 3562 Journals sorted alphabetically
Journal of European CME     Open Access  
Journal of Evaluation In Clinical Practice     Hybrid Journal   (Followers: 6)
Journal of Evidence-Based Healthcare     Open Access   (Followers: 1)
Journal of Evidence-Based Integrative Medicine     Open Access   (Followers: 18)
Journal of Evidence-Based Medicine     Partially Free   (Followers: 4)
Journal of Exercise Science & Fitness     Open Access   (Followers: 29)
Journal of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
Journal of Family and Community Medicine     Open Access   (Followers: 3)
Journal of Family Medicine and Primary Care     Open Access   (Followers: 11)
Journal of Foot and Ankle Research     Open Access   (Followers: 6)
Journal of Forensic Science and Research     Open Access   (Followers: 2)
Journal of Gandaki Medical College-Nepal     Open Access  
Journal of Generic Medicines     Hybrid Journal   (Followers: 2)
Journal of Geographical Sciences     Hybrid Journal   (Followers: 1)
Journal of Global Antimicrobial Resistance     Hybrid Journal   (Followers: 3)
Journal of Hand Therapy     Hybrid Journal   (Followers: 19)
Journal of Head & Neck Physicians and Surgeons     Open Access   (Followers: 2)
Journal of Health & Medical Informatics     Open Access   (Followers: 62)
Journal of Health and Biological Sciences     Open Access   (Followers: 1)
Journal of Health Design     Open Access   (Followers: 1)
Journal of Health Economics and Outcomes Research     Open Access   (Followers: 1)
Journal of Health Promotion and Behavior     Open Access  
Journal of Health Research and Reviews     Open Access  
Journal of Health Science and Medical Research     Open Access  
Journal of Health Science Research     Open Access  
Journal of Health Sciences     Open Access   (Followers: 1)
Journal of health sciences     Open Access  
Journal of Health Sciences / Sağlık Bilimleri Dergisi     Open Access  
Journal of Health Sciences and Medicine     Open Access  
Journal of Health Sciences and Medicine     Open Access   (Followers: 6)
Journal of Health Sciences and Surveillance System     Open Access  
Journal of Health Sciences Scholarship     Open Access  
Journal of Health Specialties     Open Access  
Journal of Health Studies     Open Access  
Journal of Healthcare Informatics Research     Hybrid Journal   (Followers: 1)
Journal of Heavy Metal Toxicity and Diseases     Open Access  
Journal of Helminthology     Hybrid Journal   (Followers: 2)
Journal of Herbs Spices & Medicinal Plants     Hybrid Journal  
Journal of HIV for Clinical and Scientific Research     Open Access   (Followers: 2)
Journal of Hospital Medicine     Hybrid Journal   (Followers: 11)
Journal of Huazhong University of Science and Technology [Medical Sciences]     Hybrid Journal  
Journal of Human Hypertension     Hybrid Journal   (Followers: 3)
Journal of Human Rhythm     Open Access  
Journal of Human Transcriptome     Open Access  
Journal of Ideas in Health     Open Access  
Journal of Inflammation     Open Access   (Followers: 2)
Journal of Inflammation Research     Open Access  
Journal of Injury and Violence Research     Open Access   (Followers: 6)
Journal of Innovation in Health Informatics     Open Access   (Followers: 17)
Journal of Institute of Medicine     Open Access  
Journal of Insulin Resistance     Open Access   (Followers: 1)
Journal of Interactional Research in Communication Disorders     Hybrid Journal   (Followers: 5)
Journal of Interferon & Cytokine Research     Hybrid Journal   (Followers: 3)
Journal of International Medical Research     Open Access   (Followers: 3)
Journal of Interventional Medicine     Open Access   (Followers: 1)
Journal of Investigative Medicine     Hybrid Journal   (Followers: 3)
Journal of Islamabad Medical & Dental College     Open Access   (Followers: 2)
Journal of Istanbul Faculty of Medicine     Open Access  
Journal of Karnali Academy of Health Sciences     Open Access   (Followers: 1)
Journal of Kathmandu Medical College     Open Access   (Followers: 1)
Journal of King Abdulaziz University : Medical Sciences     Open Access   (Followers: 2)
Journal of Laboratory Medicine     Hybrid Journal   (Followers: 27)
Journal of Laryngology and Voice     Open Access   (Followers: 11)
Journal of Lasers in Medical Sciences     Open Access  
Journal of Law, Medicine & Ethics     Hybrid Journal   (Followers: 27)
Journal of Legal Medicine     Hybrid Journal   (Followers: 7)
Journal of Limb Lengthening & Reconstruction     Open Access  
Journal of Lumbini Medical College     Open Access   (Followers: 1)
Journal of Mahatma Gandhi Institute of Medical Sciences     Open Access  
Journal of Manipulative and Physiological Therapeutics     Hybrid Journal   (Followers: 6)
Journal of Manmohan Memorial Institute of Health Sciences     Open Access   (Followers: 1)
Journal of Marine Medical Society     Open Access  
Journal of Materials Science : Materials in Medicine     Hybrid Journal   (Followers: 4)
Journal of Maternal and Child Health     Open Access  
Journal of Mechanics in Medicine and Biology     Hybrid Journal  
Journal of Medical and Biological Engineering     Hybrid Journal   (Followers: 4)
Journal of Medical and Biomedical Sciences     Open Access   (Followers: 2)
Journal of Medical Case Reports     Open Access   (Followers: 1)
Journal of Medical Cases     Open Access   (Followers: 6)
Journal of Medical Colleges of PLA     Full-text available via subscription  
Journal of Medical Disorders     Open Access  
Journal of Medical Economics     Hybrid Journal   (Followers: 8)
Journal of Medical Education and Curricular Development     Open Access   (Followers: 6)
Journal of Medical Ethics     Partially Free   (Followers: 26)
Journal of Medical Ethics and History of Medicine     Open Access   (Followers: 19)
Journal of Medical Humanities     Hybrid Journal   (Followers: 21)
Journal of Medical Hypotheses and Ideas     Open Access  
Journal of Medical Imaging and Health Informatics     Full-text available via subscription   (Followers: 1)
Journal of Medical Investigation and Practice     Open Access  
Journal of Medical Laboratory and Diagnosis     Open Access  
Journal of Medical Law and Ethics     Full-text available via subscription   (Followers: 17)
Journal of Medical Microbiology     Full-text available via subscription   (Followers: 6)
Journal of Medical Sciences     Open Access  
Journal of Medical Sciences     Open Access  
Journal of Medical Screening     Hybrid Journal   (Followers: 6)
Journal of Medical Signals and Sensors     Open Access   (Followers: 3)
Journal of Medical Society     Open Access  
Journal of Medical Systems     Hybrid Journal  
Journal of Medical Toxicology     Hybrid Journal   (Followers: 6)
Journal of Medical Ultrasound     Open Access   (Followers: 2)
Journal of Medicinal Botany     Open Access  
Journal of Medicinal Chemistry     Hybrid Journal   (Followers: 206)
Journal of Medicine     Open Access   (Followers: 1)
Journal of Medicine and Biomedical Research     Open Access   (Followers: 1)
Journal of Medicine and Philosophy     Hybrid Journal   (Followers: 9)
Journal of Medicine and the Person     Hybrid Journal  
Journal of Medicine in Scientific Research     Open Access  
Journal of Medicine in the Tropics     Open Access  
Journal of Medicine Research and Development     Open Access   (Followers: 3)
Journal of Medicine, Physiology and Biophysics     Open Access   (Followers: 5)
Journal of Medicines Development Sciences     Open Access   (Followers: 1)
Journal of Metabolomics & Systems Biology     Open Access   (Followers: 2)
Journal of Mind and Medical Sciences     Open Access   (Followers: 1)
Journal of Molecular Medicine     Hybrid Journal   (Followers: 11)
Journal of Movement Disorders     Open Access   (Followers: 2)
Journal of Multidisciplinary Research in Healthcare     Open Access   (Followers: 1)
Journal of Muscle Research and Cell Motility     Hybrid Journal   (Followers: 1)
Journal of Nanotechnology in Engineering and Medicine     Full-text available via subscription   (Followers: 6)
Journal of Nanotheranostics     Open Access   (Followers: 1)
Journal of Natural Medicines     Hybrid Journal  
Journal of Natural Science, Biology and Medicine     Open Access   (Followers: 3)
Journal of Nature and Science of Medicine     Open Access   (Followers: 4)
Journal of Negative and No Positive Results     Open Access  
Journal of Nepalgunj Medical College     Open Access  
Journal of Neurocritical Care     Open Access  
Journal of Neurodegenerative Diseases     Open Access   (Followers: 2)
Journal of Neurorestoratology     Open Access  
Journal of Neuroscience and Neurological Disorders     Open Access  
Journal of Nobel Medical College     Open Access  
Journal of Obesity and Bariatrics     Open Access   (Followers: 2)
Journal of Occupational Health     Open Access  
Journal of Occupational Therapy Education     Open Access   (Followers: 12)
Journal of Ocular Biology, Diseases, and Informatics     Hybrid Journal  
Journal of Oral Biology and Craniofacial Research     Full-text available via subscription  
Journal of Oral Health and Craniofacial Science     Open Access  
Journal of Orofacial Sciences     Open Access  
Journal of Otorhinolaryngology, Hearing and Balance Medicine     Open Access   (Followers: 1)
Journal of Ovarian Research     Open Access  
Journal of Ozone Therapy     Open Access  
Journal of Palliative Medicine     Hybrid Journal   (Followers: 47)
Journal of Paramedical Sciences & Rehabilitation     Open Access  
Journal of Parkinsonism and Restless Legs Syndrome     Open Access   (Followers: 2)
Journal of Parkinson’s Disease and Alzheimer’s Disease     Open Access   (Followers: 1)
Journal of Participatory Medicine     Open Access  
Journal of Patan Academy of Health Sciences     Open Access  
Journal of Pathogens     Open Access   (Followers: 1)
Journal of Patient Experience     Open Access  
Journal of Patient Safety and Risk Management     Hybrid Journal   (Followers: 2)
Journal of Patient-Centered Research and Reviews     Open Access  
Journal of Patient-Reported Outcomes     Open Access  
Journal of Periodontal Research     Hybrid Journal  
Journal of Personalized Medicine     Open Access   (Followers: 3)
Journal of Pest Science     Hybrid Journal   (Followers: 1)
Journal of Pharmaceutical Policy and Practice     Open Access   (Followers: 4)
Journal of Physiobiochemical Metabolism     Hybrid Journal   (Followers: 2)
Journal of Physiology-Paris     Hybrid Journal   (Followers: 2)
Journal of Pioneering Medical Sciences     Open Access  
Journal of Postgraduate Medicine     Open Access  
Journal of Pregnancy     Open Access   (Followers: 4)
Journal of Prevention & Intervention Community     Hybrid Journal   (Followers: 7)
Journal of Preventive Medicine and Public Health     Open Access  
Journal of Primary Prevention     Hybrid Journal   (Followers: 7)
Journal of Prosthodontic Research     Full-text available via subscription   (Followers: 1)
Journal of Prosthodontics     Hybrid Journal   (Followers: 2)
Journal of Receptor, Ligand and Channel Research     Open Access   (Followers: 1)
Journal of Regenerative Medicine     Partially Free   (Followers: 4)
Journal of Research in Medical Sciences     Open Access   (Followers: 2)
Journal of Science and Applications : Biomedicine     Open Access   (Followers: 1)
Journal of Science and Technology (Ghana)     Open Access   (Followers: 3)
Journal of Scientific Innovation in Medicine     Open Access  
Journal of Scientific Perspectives     Open Access   (Followers: 1)
Journal of Sensory Studies     Hybrid Journal   (Followers: 4)
Journal of Shaheed Suhrawardy Medical College     Open Access  
Journal of Shoulder and Elbow Arthroplasty     Open Access  
Journal of Sleep Disorders : Treatment & Care     Hybrid Journal   (Followers: 10)
Journal of South American Earth Sciences     Hybrid Journal   (Followers: 5)
Journal of Spinal Cord Medicine     Hybrid Journal   (Followers: 5)
Journal of Spinal Disorders & Techniques     Hybrid Journal   (Followers: 2)
Journal of Sports Medicine and Allied Health Sciences : Official Journal of the Ohio Athletic Trainers Association     Open Access   (Followers: 1)
Journal of Stem Cell Therapy and Transplantation     Open Access   (Followers: 1)
Journal of Stomal Therapy Australia     Full-text available via subscription   (Followers: 1)
Journal of Strength and Conditioning Research     Hybrid Journal   (Followers: 77)
Journal of Substance Use     Hybrid Journal   (Followers: 15)
Journal of Surgical Academia     Open Access   (Followers: 1)
Journal of Surgical and Clinical Research     Open Access  
Journal of Surgical Case Reports     Open Access  
Journal of Surgical Education     Full-text available via subscription   (Followers: 3)
Journal of Surgical Technique and Case Report     Open Access  
Journal of Systemic Therapies     Full-text available via subscription   (Followers: 3)
Journal of Taibah University Medical Sciences     Open Access  
Journal of Telemedicine and Telecare     Hybrid Journal   (Followers: 12)
Journal of The Academy of Clinical Microbiologists     Open Access  
Journal of the American Association for Laboratory Animal Science     Full-text available via subscription   (Followers: 9)
Journal of the American College of Certified Wound Specialists     Hybrid Journal   (Followers: 2)
Journal of the American College of Clinical Wound Specialists     Hybrid Journal   (Followers: 2)
Journal of the American Medical Directors Association     Hybrid Journal   (Followers: 5)
Journal of the American Medical Informatics Association : JAMIA     Hybrid Journal   (Followers: 36)
Journal of the American Podiatric Medical Association     Full-text available via subscription   (Followers: 7)
Journal of the Anatomical Society of India     Full-text available via subscription  
Journal of the Anus, Rectum and Colon     Open Access  

  First | 3 4 5 6 7 8 9 10 | Last

Similar Journals
Journal Cover
Journal of Health Sciences and Medicine
Number of Followers: 6  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2636-8579
Published by DergiPark Homepage  [214 journals]
  • The relationship between serum homocysteine levels and development of
           coronary collateral circulation in patients with acute coronary syndrome

    • Authors: Muhammed KARADENİZ ; Tuba Betül KARADENİZ , Taner SARAK , Çağlar ALP
      Abstract: Aim:Homocysteine is an amino acid that plays a role in folate metabolism andinhibits endothelial cell proliferation which is important for angiogenesis. Inthis study, we aimed to investigate the relationship between serum homocysteinelevels and coronary collateral development. Materialand Method: 176consecutive patients, with acute coronary syndrome and chronic total occlusion,were divided into two groups according to coronary collateral development. Rentrop0 and 1 were regarded as group I and Rentrop 2 and 3 as group II. Results: Plasma homocysteine levels were 18,2 ± 7,0 μmol/Lin the group I and 15,7 ± 5,1 μmol/L in the group II. Univariate logistic regression analysis showed that meanplatelet volume and homocysteine were associated with poor coronary collateral.Multivariate logistic regression analysis showed that homocysteine level wasindependently associated with poor coronary collateral circulation (OR 1,069[95% CI 1,012-1,130]; P=0,018).Conclusion: In this study clearly demonstrates that high serumhomocysteine level is associated with poor collateral development in patientswithacute coronary syndrome.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Retrospective analysis of clinical and laboratory data at the time of
           admission in type 2 diabetic patients admitted to the internal medicine
           outpatient clinic

    • Authors: Ömer AKYÜREK
      Abstract: ABSTRACTAim: Type 2 diabetes mellitus isa chronic metabolic disease requiring continuous medical care due to insulindeficiency or insulin-effect defects. The aim of this study is to evaluate theclinical and laboratory findings of type 2 diabetes mellitus patients anddiscuss the findings in the light of literature.Materialand Method: This study is a descriptive cross-sectional study with 186 patients overthe age of 18 who were enrolled in three years in the general internal medicineoutpatient clinic of our hospital with the diagnosis code 'type 2 diabetesmellitus.  Results: 186 patients were includedin the study (mean age 59.7±11.5 years). The disease duration of the patientswas 1-27 years, the median was 9 years and 37.1% (n: 69) of them had a diseaseduration of over 10 years. The mean HbA1c of the patients was 7.9±1.7%, themean HDL level was 46.2 ± 10.9 mg/dL, and the median LDL level was 117 mg/dL.In 55.9% (n: 104) of type 2 diabetes mellitus patients, HbA1c level was 7% andabove, and the percentage of the patients with LDL cholesterol level of 100 andabove was 58% (n: 108). Result: New health care policies tomitigate the risk factors of diabetic patients should be planned and suchfactors should be examined in depth for the early detection of diabetes-relatedcomplications and reduction in treatment costs and treated with amultidisciplinary approach. ry approach.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Monocyte to HDL ratio as an indicator of subclinical atherosclerosis in
           diabetic retinopathy

    • Authors: Seyfullah KAN ; Adnan KARAİBRAHİMOĞLU
      Abstract: ABSTRACTAim: Incidence of cardiovasculardiseases is gradually increasing in patients with diabetic retinopathy (DR).MHR (Monocyte/HDL ratio), is a novel marker related with cardiovascular andcerebrovascular diseases. The aim of this study was to investigate therelationship between a subclinical atherosclerosis marker, carotid intima mediathickness (CIMT), and MHR in diabetic retinopathy patients without an apparentcardiovascular disease. Materialand Method: 106 diabetic patients without an apparentcardiovascular disease and 35 healthy controls matched for age, gender and bodymass index (BMI) were included in this study. The patients were separeted into four groups which were proliferativediabetic retinopahy (PDR , n=30), nonproliferative diabetic retinopathy (NPDR,n=35), diabetic patients without retinopathy (n=41) and control group (n=35).Anthropometric, biochemical parameteres and CIMT were measured. Correlation andregression analysis were done to assess the relation between MHR and CIMT. Results:MHR wassignificantly different betweengroups and significantly higher in PDR group (p < .001). CIMT, a marker for atherosclerosis, significantlydiffered between groups (p <.001). CIMT levels were significantly higher in PDR while similar values werefound in other than groups. In PDR group, a significant correlation was foundbetween MHR and CIMT ( r=0.96; p < .001). According to binary logistic regression analysis,MHR had a significant effect on CIMT [ β=0.206, (%95 CI : 1.004-1.505), P=0.046].Conclusion: This study showed that  in patients with diabetic retinopathy, highlevels of MHR which is a non-invasive, simple and inexpensive marker, might beuseful for determination of subclinical cardiovascular risk. This study whichis the first in literature that investigated the relation between MHR and CIMTin diabetic retinopathy might have a benefit on early detection of cardiac riskin diabetic patients without an apparent cardiovascular disease.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • The significance of ankle-brachial index in determining peripheral artery
           disease in patients with type 2 diabetes mellitus over 40 years of age and
           the relationship of peripheral artery disease with chronic complications
           of diabetes

    • Authors: Tuğçe Nur YİĞENOĞLU ; Medine Nur KEBAPÇI , Hülya ÖZEN
      Abstract: Introduction: Peripheral artery disease(PAD) acts as an important predictor of mortality and morbidity incerebrovascular and cardiovascular diseases. The incidence of PAD was reportedto be 2 to 4 times higher in diabetic patients compared with non-diabeticpatients. Ankle brachial  index (ABI) isan easily applicable method for the diagnosis of PAD. The aim of this study isto determine the prevalence of PAD by using ABI in patients with Type 2Diabetes Mellitus (DM) over 40 years of age, compare the results with lowerextremity arterial Doppler ultrasonography (USG) and to reveal the relationshipbetween chronic complications of DM and PAD. Material and Method: The study included111 DM patients over 40 years of age. ABI; was calculated by dividing thehigher systolic blood pressures (SBP) taken from both ankle levels to thehigher SBPs measured in both arms and defined as "ABI-1". ABI-2 wascalculated by dividing the lower SBPs taken from both ankle levels to thehigher SBPs measured from both arms. ABI values ​​calculated by both methodswere divided into 3 groups according to cut off values. ABI values ​​of 0.9 andless in Group 1, ​​between 0.9 and 1.30 in Group 2, ​​between 0.9 and 1.40 inGroup 3 were interpreted in favor of PAD. Results: The prevalence of PAD was19.8%. The most specific group for detecting PAD was ABI-2G1, and the mostsensitive groups were ABI-1G2 and ABI-2G2. A significant relationship was foundbetween PAD and clopidogrel use, decreased vibration sensation, age, durationof DM, insulin resistance, glomerular filtration rate, albuminuria,homocysteine ​​and uric acid levels. Conclusion: ABI is a sensitive methodfor detecting PAD. Thesuperior side of our study compared to the other studies is that the ABI iscalculated by 2 methods and ABI values are divided into 3 groups according tocut off values (≤0,9 ; ≤0,9 - >1,30 ; ≤0,9 - >1,40).
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Factors influencing study of physiotherapy and preferred choice of
           specialisation among final year physiotherapy students in Nigeria

    • Authors: Ayodeji FABUNMİ ; Babafemi ADEBAJO , Theresa AKİNOLA
      Abstract: Introduction:Over the yearsincreasing number of students are seeking admission to study Physiotherapy inthe universities leading to increased preference for specialisation as comparedwith general practice. This aim of this study was to identify factorsinfluencing the study of physiotherapy and preferred choice of specialisation. Material and Method: The research was across-sectional survey involving final year physiotherapy students in threetraining institutions in South-West, Nigeria. The questionnaire is in three sections(section A sought responses on Socio-demographic characteristics, section B on factorsinfluencing the study of Physiotherapy and section C on preferred choice ofspecialization). Content validation was carried out to eliminate ambiguity andensure that all items of the questionnaire are relevant and well understood. Descriptivestatistics of percentages, bar chart and mean was used to summarize data onage, factors influencing study of physiotherapy, the level of influence of eachfactor on preferred specialization areas of each participant and the factorsinfluencing the choice of specialization. Result: There was a response rate of 72.2%and mean age was 22.69±2.32 years. Out of the eight factors influencing studyof physiotherapy, ‘Desire to help people optimise their physical health and ‘Personalinterest’ had the greatest influence with mean scores of 3.24 and 3.18 respectively.Ninety-eight participants (94.26%) were interested in pursuing postgraduatespecialization in Physiotherapy. Orthopaedics and Musculoskeletal physiotherapyis the most preferred specialization while Geriatrics is the least preferredspecialization. Male students have preference for Sports while female havepreference for Paediatric specialty. Conclusion: Exposure to specialties inPhysiotherapy like Geriatrics and Cardio-pulmonary may help improve interest inthose areas and hence increased preference for those specialties.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Investigation of the anti-cancer effect of Rheum Ribes L.'s ethanol
           extracts on malign melanoma cells

    • Authors: Adnan KİRMİT ; Kasım TAKIM , Ezgi DURMUŞ , Eray Metin GÜLER , Vildan Betül YENİGÜN , Huri BULUT , Abdurrahim KOÇYİĞİT
      Abstract: Objective: Işkın (Rheum ribes L.), China, India, Iran and Turkey are grow in the wild and are used for many medical purposes. The aim of this study is to investigate the anti-cancer effectiveness of ethanol extracts of the roots, stems and bark of the Rheum ribes L against malignant melanoma cells. Material and Method: Root, stem and bark parts of the plant dried at room temperature were powdered with a mixer and incubated with 50% ethanol for 24 hours. In the extracts obtained after the organic phase is evaporated in a rotary evaporator and the water phase is separated in the lyophilizer; firstly, total phenol and total flavanoid content level and total antioxidant capacity were measured by photometric methods. Cultured malignant melanoma cells (B16F10) were incubated at different concentrations of these extracts for 24 hours. After incubation; cytotoxicity levels was determined with the colorometric MTT method [3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide], and the apoptosis level by Acridine Orange-Ethidium Bromide (AO-EB) double staining method. Results: When examining the results of both cytotoxicity and apoptosis, it was observed that the highest cytotoxic (87.57 ± 4.3%) and apoptotic (59.76 ± 3.57) effects were achieved with root extracts at the same concentrations (p <0.001). According to MTT results, IC50 value of root extracts was determined to be 61 µg/mL and cell death at 500 µg/mL as 91.92 ± 3.9. Conclusion: It has been concluded that Rheum ribes L. plant has anticancer activity on malignant melanoma cells and the root extract has a higher anti-cancer drug potential compared to the stem and barks of the plant.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Prevalence and risk factors of hemodynamic instability during endoscopic
           transsphenoidal pituitary surgery: a retrospective analysis

    • Authors: Fahri ACAR ; Oya KILCI , Gülçin Hilal ÖZTÜRK ALAY , Canan ÜN , Hidayet ÜNAL , Derya GOKCİNAR
      Abstract: Objective: Intraoperative hemodynamic instability in patients undergoing endoscopic transsphenoidal pituitary surgery (ETSS) for pituitary adenoma may lead to significant complications. We aimed to investigate the prevalence of hemodynamic instability and its associated risk factors in these patients.Methods: This retrospective study included patients who underwent ETSS at Ankara Numune Training and Research Hospital between 14 January 2010 and 20 March 2014. Intraoperatively occurring episodes of bradycardia, hypotension, and hypertension were recorded. Distribution of hemodynamic instability was determined based on age groups, ASA class, tumor type, and anesthesia method.Results: A total of 323 patients met the study criteria. Mean age of the patients was 46.88 ± 13.91 years and 54.5% were female. Intraoperative bradycardia was detected in 137 patients (42.41%), hypotension in 57 patients (17.65%), and hypertension in five patients (1.55%). Hemodynamic instability occurred in all of the patients over the age of 51. Patients classified as ASA III were more likely to have hemodynamic instability than patients with ASA I and ASA II (p<0.05). All 18 patients who were transferred to intensive care unit were in the age group of 61 years and over. The rate of hemodynamic instability was higher in patients with non-functioning tumor compared to that in patients with functioning tumors.Conclusion: The rate of intraoperative hemodynamic instability in patients undergoing ETSS is higher in older patients than that in young patients. The elderly has multiple comorbidities and are more sensitive to anesthetic agents. This group needs a carefully planned anesthetic management during perioperative period.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Effects of tryptophan, a precursor for melatonin, on IVF outcomes and
           Doppler parameters

    • Authors: Fatma Devran BILDIRCIN ; Handan ÇELİK , Ayşe ÖZDEMİR , Pervin KARLI , Bahattin AVCI , Sertaç BATIOĞLU
      Abstract: Aims: Melatonin is the most powerful antioxidant and protects sperm, oocyte and embryo against oxidative stress. The effect of tryptophan, which is the building block of melatonin, on follicular melatonin levels and IVF outcomes is unknown. The objective of this study was to investigate the effect of tryptophan administration, a precursor for melatonin, on the levels of intrafollicular melatonin with the aim to reveal the correlation between tryptophan and the total number and quality of oocytes as well as clinical pregnancy rates. In addition, we aimed to examine the effect of melatonin increased by tryptophan on uterine and ovarian blood flow.Methods: Out of 103 patients who applied to Ondokuzmayis University IVF clinic for IVF treatment, 51 patients were administered a 100 mg dose of tryptophan orally (Group A) and 50 control patients who were randomly selected did not receive tryptophan (Group B). Firstly, follicular melatonin levels were compared between Group A receiving tryptophan and Group B without tryptophan. Both groups were also compared according to the oocyte count, oocyte count, fertilized oocyte count, embryo count and pregnancy rates, ultimately. In addition, all patients were measured for uterine and ovarian artery blood flow by vaginal ultrasound on the day of OPU..Results: There were no differences in age (32.16 ± 3.82 years vs 33.06 ± 4.44 years) (p = 0.276), BMI (28.45 ± 2.82 kg/m)2 vs 28.15 ± 3.03kg/m2 (p = 0.602) and peak estradiol levels (2451.69 ± 469.75 pg/ml vs 2420.26 ± 443.71 pg / ml) (p = 0.73) between the groups. Group A exhibited high levels of melatonin in the follicular fluid with a mean value of 259.8 pg/ml, whereas Group B had 91.3 pg/ml (p <0.001). There were found significant differences in the oocyte count (9.08 ± 3.22 vs 7.66 ± 1.89) (p = 0,008), mature oocyte count (7.2 ± 2.8 vs 6.1 ± 1.8) (p = 0,021) and fertilized oocyte count (6.35 ± 2.44 vs 5.28 ± 1.69) between group A and group B. Pregnancy rates were higher in group A (35.3%). The pregnancy rate (30%) was lower in Group B, which did not receive tryptophan and had low melatonin levels in follicular fluid. However, there was no statistically significant difference. Uterine, ovarian artery systolic and diastolic blood flows of Group A were significantly lower than Group B (P <0.001).Conclusions: Administration of tryptophan to IVF patients significantly increases the level of melatonin in follicular fluid. The results demonstrate that high levels of melatonin in follicular fluid may increase oocyte count and quality although they do not significantly improve clinical pregnancy rates.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • The value of late phase imaging with FDG-PET/CT in liver metastases of
           colorectal carcinoma

    • Authors: Aylin AKBULUT ; Burcu ESEN AKKAŞ, Nahide GÖKÇORA , Neşe İLGİN KARABACAK, Mehmet Tevfik KİTAPÇI
      Abstract: Aim: Our aim was investigated the role of late phase imaging with F18-FDG-PET/CT in colorectal carcinoma patients with liver metastases. Method: Dual phase FDG-PET/CT scan was retrospectively evaluated in colorectal carcinoma patients with liver metastases. Late phase imaging was acquired 92-253 minutes (mean 158.53±35.7 minutes) after the FDG injection. Sixty-eight metastatic lesions were determined in 37 patients. Mean lesion SUVmax and lesion-to non-tumorous liver tissue ratio were calculated and results of routine FDG-PET imaging were compared with late phase imaging. Results: Metastatic lesion sizes were 9 to230 mm (mean 3.71±3.7 cm). SUVmax values of the metastasis and non-tumorous liver SUVmax for routine and late-phase imaging were as follows; 7.19±3.8, 10.3±5.4; 2.98±0.7, 2.41±0.6 respectively. Metastatic liver lesions, SUVmax values were increased (p 0.01) and non-tumorous liver SUV max values were decreased (p 0.01) in late phase imaging. Compared to routine imaging, in late phase lesion to non-tumorous liver tissue was increased (p 0.001). Lesion retention index was 45.74± 31.8% and the non-tumorous liver index was decreased 18.63 ± 10.4%. Conclusion: The results of this study indicates that normal liver FDG uptake decreases in time and late phase imaging improves the tumor to normal tissue ratio and enable differentiation of metastatic liver lesions from normal liver.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • A rare cause of severe earache: a tick in the external auditory canal

    • Authors: Ceyhun AKSAKAL
      Abstract: Although tick is rarely seen in the external auditorycanal, it may cause pain and tinnitus in the ear. In addition, it is alsoimportant in terms of causing Crimean-Congo hemorrhagic fever disease. In thisreport, we presented the treatment of a 60-year-old patient who was admitted tothe Emergency Service with pain in the left ear and who had a tick in theexternal auditory canal together with literature data. Removing he tick fromthe external ear canal with the alligator forceps in a careful manner is importantin terms of preventing many diseases that might occur due to the tick. 
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • The effects of dialysis modalities on sexual hormone levels in male
           patients

    • Authors: Kadir Gökhan ATILGAN ; Mehmet Deniz AYLI , Ali YALCİNDAĞ , Fatih YAY , Ebru GÖK OĞUZ , Gülay ULUSAL OKYAY , Fatma AYERDEN EBİNÇ
      Abstract: Introduction:Low testosterone level is association with low quality of life and cardiovascular risk factors. The dialysis modality effects on testosterone levels remain unclear. To investigate the haemodialysis (HD) and peritoneal dialysis (PD) effects on male sexual hormones.Material and Method:Serum total testosterone (TT), free testosterone (FT), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL) and sex hormone-binding globulin (SHBG) were investigated. Serum TT below 3 ng/ml was considered a low TT. Sociodemographic data and an Index of Independence in Activities of Daily Living were recorded. Results:This study included adult male HD (n = 71) and PD (n = 24) patients. Age and dialysis duration were similar between groups. Serum TT and FT levels were significantly higher in the PD group (p = 0.01 and p = 0.05, respectively). There were no differences between the HD and PD groups with regard to SHBG, FSH, LH or PRL levels (p = 0.353, p = 0.858, p = 0.410 and p = 0.410, respectively). The number of patients who were capable of performing Index of Independence in Activities of Daily Living was higher in the PD group (p = 0.033) and with normal TT levels (p = 0.027). Binary regression analysis showed more favourable effects in the PD group on testosterone levels (OR = 4.659; 1.477–14.704 95% CI Exp B). Conclusion:PD has favourable effects on testosterone levels compared to HD. Mental and physical well being resulting from PD and its technique affect TT levels.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Cervical aortic arch

    • Authors: Sefa TÜRKOĞLU ; Cihan BEDEL
      Abstract: Cervical aortic arch is an unusualcongenital anomaly. Itis usually symptomatic in childhood, but sometimes this abnormality isdiagnosed during radiological examination because of unrelated causes inasymptomatic adults.  We aimed to reporta case of cervical aortic arch andreview of the literature  which  presentedwith cough and shortness of breath. 
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Investigation of the neutrophil/lymphocyte and monocyte to high-density
           lipoprotein cholesterol ratios in differentiated thyroid cancers

    • Authors: Kenan ÇADIRCI ; Faruk YILDIZ , Havva KESKIN , Muharrem BAYRAK , Hilal KİZİLTUNC OZMEN , Şenay ARIKAN DURMAZ , Ayşe ÇARLIOĞLU
      Abstract: ABSTRACTIntroduction: Thyroid cancers are the most common malignant tumors of endocrine origin. They are classified depending on their histopathological and clinical behaviors. Papillary and follicular cancers are classified as differentiated thyroid carcinomas (DTCs). The neutrophil/lymphocyte ratio (NLR) and the monocyte to high-density lipoprotein cholesterol ratio (MHR) have recently been shown to be powerful markers of oxidative stress and systemic inflammation, and the MHR has been revealed as a potent marker of mortality in coronary heart disease associated with coronary atherosclerosis. The aim of this study was to evaluate these markers in patients diagnosed with DTC. Material and Method: One hundred twenty-five patients newly diagnosed with DTC and a 75-member control group consisting of entirely healthy individuals were included in the study. The patient and control groups were evaluated by investigation of cholesterol and hematological parameters following 12-h fasting. MHR and NLR values were calculated manually on SPSS software.Results: Significant differences were determined between the patient and control groups in terms of mean NLR (3.2±2.8 vs 2.4±1.3, respectively, p=0.013) and MHR (0.038±0.052 vs 0.102±0.079, respectively, p=0.0000) values. In the correlation analysis, positive correlation was determined between the NLR and white cell count (r=0.530, p<0.001), neutrophil count (r=0.293, p<0.001) and CRP (r=0.371, p=0.005), while negative correlation was determined between the NLR and lymphocyte count (r=-0.271, p=0.001).Conclusion: The study data show that DTCs increase systemic inflammation.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Interobserver reliability in the ultrasonic evaluation with graf method of
           developmental dysplasia of the hip: the importance of education for
           ultrasonography classification

    • Authors: Kadri YILDIZ ; Hayrunnisa BEKİS BOZKURT BEKİS, Türkhun ÇETİN , Vahit YILDIZ
      Abstract: Aim: Developmental dysplasia of the hip is a hip deformity that can be diagnosed early by numerous ultrasonic measurements. The purpose of this study was to evaluate the interobserver reliability of ultrasonic measurements using the Graf Ultrasound (USG) method.Methods: Ultrasonic measurements that were used by Graf Ultrasound (USG) method were obtained at presentation for 62 randomized and consecutive patients. Bilateral hip USG measurements were made for each patient. Each USG outcome was evaluated on multiple occasions by an orthopedic surgery specialist, a pediatric specialist, and a 25-year experienced radiologist.The statistical measurements were made by SPSS 20.0 (Windows, IL, USA). Intraclass Correlation Coefficient was determined. 95% Confidence Interval and F Test with True Value 0 was detected. P values were accepted as statistically significantly less than 0,05.Results: At the evaluation before education for Graf USG classification, the results were established. In the interobserver reliabilities, Intraclass Classification Correlations (ICC) values were 0,939 for USG classification evaluation with Graf Method for right hips. ICC values were 0,907 for USG classification evaluation with Graf Method for left hips. At the evaluation after education for Graf USG classification, the results were established. ICC values were 0,975 for USG classification evaluation with Graf Method for right hips. ICC values were 0,970 for USG classification evaluation with Graf Method for left hips. All p values were significant. While before education for Graf USG classification ICC was 0,838 in right hips, 0,765 in left hips; after education, it was 0,928 in right hips, 0,915 in left hips.Conclusion: Diagnosis of DDH deformity with USG is a complex and difficult condition that needs a serious education period. Graf USG method was found to have high interobserver reliability. And also, we detected that education for Graf USG classification increased intra-observer reliability, especially among pediatrists.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Noninvasive assesment in differentiating benign and malign pancreatic
           lesions with endosonographic elastography score and strain ratio

    • Authors: Özlem Gül UTKU ; Bilal ERGÜL , Eylem KARATAY , Cumali EFE , Nesrin TURHAN , Dilek OĞUZ
      Abstract: Background: We aimed to evaluate the diagnostic capability of endoscopic ultrasound elastography (EUS-EG) and strain ratio (SR) for differentiating benign pancreatic lesions from the malign lesions Material and Method: We retrospectively evaluated well collected data of patients who undergone EUS-EG in a single centre during the period of January 2016-June 2019. Patients who had pancreatic disorders were further evaluated for the study. The final diagnosis of solid pancreatic lesions (SPL) was made by histopathologic examination. Control group consisted of patients with chronic pancreatitis (CP) who diagnosed according to Rosemont criteria. Elastography was evaluated by a qualitative (elastography scores) and a quantitative method SR. Results: A total of 66 patients (42 (63.6%)female/42 (63.6%)male) with mean age of 58.88±15.32 (19- 80) were included in the study. Thirty-eight patients had SLP, remain 28 patients were CP. In SPL group, 32 (84.2%) had adenocarcinomas and 6 (15.8%) had neuroendocrine tumors. Among 28 patients with benign pancreatic lessions, 23 (82.1%) had CP while five (17.9%) had autoimmune pancreatitis. Median SR values were significantly higher in patients with SPL than those with CP (44.0 (10.0-110.0) vs 7.0 (2.6-14.6), p<0.001). Elasticity scores were also significantly different between patients with SLP and CP (p<0.001). Elasticity scores were significantly different between adenocarcinomas and CP (p<0.001). A 14 cut-off value of SR had 97% sensitive and 100% specificity for SPL and receiver-operating characteristic curves showed an area under the curve of 0.99.6. Likelihood Ratio test revealed that SR appears as the best parameter in discrimination of lesion type either as benign or malignant (X2 = 54.031, p<0.001).Conclusion: Our study suggested that EUS-elastography and SR scores are highly effective in differentiating malign-benign pancreatitis lesions
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Medical nutrition therapy in cystic fibrosis

    • Authors: Elif EDE ; Sabiha Zeynep Aydenk KÖSEOĞLU
      Abstract: Cystic fibrosis (CF) is a genetic disorder with multisystem involvement in children and adults. In Newborns, the most frequent occurrence in Europe is the frequency of having a disease in different ethnic origins, ranging from 1/3500 to 1/30000. In order to extend the expected life span and increase the survival rate in patients with CF, it is necessary to put the diagnosis early and to start treatment early. Inadequate use of energy due to digestive failure in CF, increased energy need, gastrointestinal problems and inadequate nutrition due to reduced appetite; Vitamin mineral deficiencies are also frequently seen as malabsorption origin. Malnutrition is seen in CF infants and children because of the increased need for nutrition and the inability to meet the needs. In this review, it is aimed to introduce the principles of medical nutrition therapy principles and nutritional therapy in Cystic Fibrosis.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Effect of concentrated growth factor on random pattern skin flap
           viability: experimental study

    • Authors: Koray GÜRSOY ; Gökhan KOCA , Murat ALIŞIK , Nihat YUMUŞAK , Meliha KORKMAZ , Uğur KOÇER
      Abstract: Introduction: Random pattern skin flaps are used frequently for the reconstruction of random patern skin defects from various causes in plastic and reconstructive surgery. Most frequent complication with these flaps is the necrosis of distal parts due to inadequate blood supply. Various types of techniques have been defined to avoid and reduce flap loss. The aim of this study is to first time evaluate the effect of concentrate growth factor (CGF), which is derived from whole blood and is rich in growth factors, on the survival of random pattern skin flaps.Material and Method: Fifty Sprague-Dawley rats were used for the study. Forty of them were used for the experiment group and ten for the preparation of CGF. Distal based 3x9 cm Mcfarlene flaps were elevated from the back of the rats and in CGF group (n:20), CGF matrix was placed before closure. The control group (n:20) did not get any treatment. On postoperative day 7, the flaps were evaluated by photographic, scintigraphic, and histopathological methods. Results: The median rate of surviving flap areas in control group was 53% (47-58). In CGF group the median rate of flap viability was %58 (55-64). The higher flap viability rates obtained from CGF applied group was found to be statistically significantly higher from control group (p<0,001). For the scintigraphic perfusion area evaluations, the median rate of flap perfusion was 54% (51-60) for the control group and 61% (59-64) for the CGF group. The higher flap perfusion rates obtained from CGF applied group was found to be statistically significantly higher from control group (p=0,001). The median rate of vascularity scores in CGF treated group was 10,0 (8,25-11,75) and 7,5(6,25-9,00) in control group. The difference was found to be statistically significantly higher in the study group (p=0,003). Inflammation scores were not found to be statistically significantly different (p=0,246).Conclusions: This study shows that locally applied CGF under skin flap increases flap viability which might be associated with the increase in angiogenesis. This study for the first time shows that in flap surgery, applying CGF which is rich in growth factors, might have favourable effects on the flaps that are prone to ischemia but further studies are needed.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Distraction osteogenesis and current applications of maxillofacial region:
           systematic review

    • Authors: Neşet AKAY ; Selda AKKAYA
      Abstract: Distraction osteogenesis is a new bone forming technique by stretching the callus. This technique was first developed in the long bones by the Russian orthopedist Ilizarov. Distraction osteogenesis consist of 4 stages; osteotomy period, latent period, distraction period and consolidation period. It is easy, effective and less complicated. Distraction osteogenesis is a developing technique that requires modifications and improvements to be widely used in maxillofacial surgery. A lot of research has been made in material and technique for the development of distraction osteogenesis technique and many improvements have been made. However, although these studies have not yet been completely accurate, they give positive results.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Sodium valproate in association with hyponatremia and syndrome of
           inappropriate secretion of antidiuretic hormone: a case report

    • Authors: Mehmet Hamdi ORUM
      Abstract: Sodium valproate is a drug used inneurological and psychiatric diseases and has side effects such as tremor,drowsiness, Reye-like syndrome, hepatic failure, thrombocytopenia, pancreatitis.Hyponatremia is another serious side effect of sodium valproate. Here, wereport the case of a patient with hyponatremia associated with sodium valproate.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
  • Dosimetric evaluation of the radiation exposure on radiotherapy workers

    • Authors: Fatih GÖKSEL ; Fatih DEMİRCİOĞLU
      Abstract: Aim: Radiotherapy is one of the most commonly used cancer treatment methods and high dose ionizing radiation is used to provide therapeutic effect. Radiation exposure is the biggest occupational problem for radiotherapy personnel working in this radiation environment and serious protection measures must be taken. In this regard, the last 3 years of personal dosimeter values of all the staff working in our radiation oncology clinic were examined and radiation exposure rates were evaluated.Material and Method: Between 2015 and 2018, the data of TLD measurements of personal dosimeters of all personnel were recorded, the amount of doses exposed in the measurement periods, the average doses exposed in the measurement periods according to occupational groups, the annual total dose exposure and the differences between the groups were evaluated.Results: For measurements in a total of 18 periods, the average amount of dose each employee is 0.21 mSv per period. When evaluated according to profession groups they were; 0,20 mSv in physicians, 0,20 mSv in medical physicists and 0,21 mSv in technicians. There was no statistically significant difference between the groups. While evaluating the periods individually, the doses exposed by the occupational groups are similar, but there is a significant difference between the physicians and other workers in the 1st period of 2016 and in the 5th period of 2017 and between the medical physicists and other workers in the 3rd period body doses of 2018 and the fourth period of 2018.Conclusion: Staff training, dosimetric measurements and inspections are extremely important in a radiation oncology center. All of our measurement values performed in our clinic, where we have radiotherapy experience for nearly 30 years, were determined in accordance with international standards. In this direction, it is recommended that all centers working with radiation should make current evaluations meticulously.
      PubDate: Thu, 19 Mar 2020 00:00:00 +030
       
 
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