Subjects -> MEDICAL SCIENCES (Total: 8697 journals)
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MEDICAL SCIENCES (2419 journals)                  1 2 3 4 5 6 7 8 | Last

Showing 1 - 200 of 3562 Journals sorted alphabetically
16 de Abril     Open Access   (Followers: 3)
3D Printing in Medicine     Open Access   (Followers: 5)
4 open     Open Access  
AADE in Practice     Hybrid Journal   (Followers: 6)
AAS Open Research     Open Access   (Followers: 2)
ABCS Health Sciences     Open Access   (Followers: 8)
Abia State University Medical Students' Association Journal     Full-text available via subscription   (Followers: 3)
AboutOpen     Open Access  
ACIMED     Open Access   (Followers: 1)
ACS Medicinal Chemistry Letters     Hybrid Journal   (Followers: 50)
Acta Bio Medica     Full-text available via subscription   (Followers: 2)
Acta Bioethica     Open Access  
Acta Bioquimica Clinica Latinoamericana     Open Access   (Followers: 1)
Acta Científica Estudiantil     Open Access  
Acta Facultatis Medicae Naissensis     Open Access   (Followers: 1)
Acta Herediana     Open Access  
Acta Informatica Medica     Open Access   (Followers: 2)
Acta Medica (Hradec Králové)     Open Access  
Acta Medica Bulgarica     Open Access  
Acta Medica Colombiana     Open Access   (Followers: 1)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Medica Indonesiana     Open Access  
Acta Medica International     Open Access  
Acta medica Lituanica     Open Access   (Followers: 1)
Acta Medica Marisiensis     Open Access   (Followers: 1)
Acta Medica Martiniana     Open Access  
Acta Medica Nagasakiensia     Open Access   (Followers: 1)
Acta Medica Peruana     Open Access   (Followers: 2)
Acta Médica Portuguesa     Open Access  
Acta Medica Saliniana     Open Access  
Acta Scientiarum. Health Sciences     Open Access   (Followers: 3)
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 8)
Acupuncture and Natural Medicine     Open Access  
Addiction Science & Clinical Practice     Open Access   (Followers: 9)
Addictive Behaviors Reports     Open Access   (Followers: 9)
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / Health Sciences Journal of Adıyaman University     Open Access   (Followers: 1)
Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi     Open Access   (Followers: 1)
Advanced Biomedical Research     Open Access  
Advanced Health Care Technologies     Open Access   (Followers: 10)
Advanced Science, Engineering and Medicine     Partially Free   (Followers: 9)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Bioscience and Clinical Medicine     Open Access   (Followers: 7)
Advances in Cell and Gene Therapy     Hybrid Journal   (Followers: 1)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 27)
Advances in Clinical Radiology     Full-text available via subscription   (Followers: 3)
Advances in Life Course Research     Hybrid Journal   (Followers: 11)
Advances in Lipobiology     Full-text available via subscription   (Followers: 2)
Advances in Medical Education and Practice     Open Access   (Followers: 32)
Advances in Medical Ethics     Open Access   (Followers: 3)
Advances in Medical Research     Open Access   (Followers: 2)
Advances in Medical Sciences     Hybrid Journal   (Followers: 10)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Medicine     Open Access   (Followers: 3)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 5)
Advances in Molecular Oncology     Open Access   (Followers: 2)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7)
Advances in Parkinson's Disease     Open Access   (Followers: 2)
Advances in Phytomedicine     Full-text available via subscription   (Followers: 1)
Advances in Preventive Medicine     Open Access   (Followers: 6)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 21)
Advances in Regenerative Medicine     Open Access   (Followers: 4)
Advances in Skeletal Muscle Function Assessment     Open Access  
Advances in Therapy     Hybrid Journal   (Followers: 5)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 8)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 15)
Advances in Virus Research     Full-text available via subscription   (Followers: 6)
Advances in Wound Care     Hybrid Journal   (Followers: 14)
Aerospace Medicine and Human Performance     Full-text available via subscription   (Followers: 13)
African Health Sciences     Open Access   (Followers: 5)
African Journal of Biomedical Research     Open Access   (Followers: 1)
African Journal of Clinical and Experimental Microbiology     Open Access   (Followers: 4)
African Journal of Laboratory Medicine     Open Access   (Followers: 2)
African Journal of Medical and Health Sciences     Open Access   (Followers: 3)
African Journal of Thoracic and Critical Care Medicine     Open Access  
African Journal of Trauma     Open Access   (Followers: 1)
Afrimedic Journal     Open Access   (Followers: 3)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 9)
AJOB Empirical Bioethics     Hybrid Journal   (Followers: 3)
AJSP: Reviews & Reports     Hybrid Journal   (Followers: 1)
Aktuelle Ernährungsmedizin     Hybrid Journal   (Followers: 6)
Al-Azhar Assiut Medical Journal     Open Access   (Followers: 2)
Al-Qadisiah Medical Journal     Open Access   (Followers: 1)
Alerta : Revista Científica del Instituto Nacional de Salud     Open Access  
Alexandria Journal of Medicine     Open Access   (Followers: 1)
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 3)
Alpha Omegan     Full-text available via subscription  
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 2)
Althea Medical Journal     Open Access   (Followers: 2)
American Journal of Biomedical Engineering     Open Access   (Followers: 15)
American Journal of Biomedical Research     Open Access   (Followers: 2)
American Journal of Biomedicine     Full-text available via subscription   (Followers: 7)
American Journal of Chinese Medicine, The     Hybrid Journal   (Followers: 4)
American Journal of Clinical Medicine Research     Open Access   (Followers: 8)
American Journal of Family Therapy     Hybrid Journal   (Followers: 10)
American Journal of Law & Medicine     Full-text available via subscription   (Followers: 12)
American Journal of Lifestyle Medicine     Hybrid Journal   (Followers: 7)
American Journal of Managed Care     Full-text available via subscription   (Followers: 13)
American Journal of Medical Case Reports     Open Access   (Followers: 3)
American Journal of Medical Sciences and Medicine     Open Access   (Followers: 5)
American Journal of Medicine     Hybrid Journal   (Followers: 50)
American Journal of Medicine and Medical Sciences     Open Access   (Followers: 1)
American Journal of Medicine Studies     Open Access   (Followers: 3)
American Journal of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American Journal of the Medical Sciences     Hybrid Journal   (Followers: 12)
American Journal on Addictions     Hybrid Journal   (Followers: 11)
American medical news     Free   (Followers: 3)
American Medical Writers Association Journal     Full-text available via subscription   (Followers: 6)
Amyloid: The Journal of Protein Folding Disorders     Hybrid Journal   (Followers: 5)
Anales de la Facultad de Medicina     Open Access  
Anales de la Facultad de Medicina, Universidad de la República, Uruguay     Open Access  
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1)
Analgesia & Resuscitation : Current Research     Hybrid Journal   (Followers: 7)
Anatolian Clinic the Journal of Medical Sciences     Open Access  
Anatomica Medical Journal     Open Access  
Anatomical Science International     Hybrid Journal   (Followers: 3)
Anatomical Sciences Education     Hybrid Journal   (Followers: 2)
Anatomy     Open Access   (Followers: 3)
Anatomy Research International     Open Access   (Followers: 4)
Androgens : Clinical Research and Therapeutics     Open Access  
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3)
Ankara Medical Journal     Open Access   (Followers: 2)
Ankara Üniversitesi Tıp Fakültesi Mecmuası     Open Access  
Annales de Pathologie     Full-text available via subscription  
Annales des Sciences de la Santé     Open Access  
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 3)
Annals of African Medicine     Open Access   (Followers: 2)
Annals of Anatomy - Anatomischer Anzeiger     Hybrid Journal   (Followers: 3)
Annals of Bioanthropology     Open Access   (Followers: 5)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 19)
Annals of Biomedical Sciences     Full-text available via subscription   (Followers: 4)
Annals of Clinical Hypertension     Open Access  
Annals of Clinical Microbiology and Antimicrobials     Open Access   (Followers: 15)
Annals of Family Medicine     Open Access   (Followers: 18)
Annals of Health Research     Open Access   (Followers: 1)
Annals of Ibadan Postgraduate Medicine     Open Access  
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Medicine     Hybrid Journal   (Followers: 12)
Annals of Medicine and Surgery     Open Access   (Followers: 7)
Annals of Medicine and Surgery Case Reports     Open Access   (Followers: 1)
Annals of Medicine and Surgery Protocols     Open Access   (Followers: 1)
Annals of Microbiology     Hybrid Journal   (Followers: 13)
Annals of Musculoskeletal Medicine     Open Access   (Followers: 2)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Rehabilitation Medicine     Open Access   (Followers: 1)
Annals of Saudi Medicine     Open Access  
Annals of the College of Medicine, Mosul     Open Access   (Followers: 1)
Annals of the New York Academy of Sciences     Hybrid Journal   (Followers: 5)
Annals of The Royal College of Surgeons of England     Full-text available via subscription   (Followers: 3)
Annals of the RussianAacademy of Medical Sciences     Open Access   (Followers: 1)
Annual Reports in Medicinal Chemistry     Full-text available via subscription   (Followers: 7)
Annual Reports on NMR Spectroscopy     Full-text available via subscription   (Followers: 5)
Annual Review of Medicine     Full-text available via subscription   (Followers: 18)
Anthropological Review     Open Access   (Followers: 25)
Anthropologie et santé     Open Access   (Followers: 5)
Antibiotics     Open Access   (Followers: 9)
Antibodies     Open Access   (Followers: 2)
Antibody Reports     Open Access   (Followers: 1)
Antibody Technology Journal     Open Access   (Followers: 1)
Antibody Therapeutics     Open Access   (Followers: 1)
Anuradhapura Medical Journal     Open Access  
Anwer Khan Modern Medical College Journal     Open Access   (Followers: 2)
Apmis     Hybrid Journal   (Followers: 2)
Apparence(s)     Open Access   (Followers: 1)
Applied Clinical Informatics     Hybrid Journal   (Followers: 5)
Applied Clinical Research, Clinical Trials and Regulatory Affairs     Hybrid Journal   (Followers: 2)
Applied Medical Informatics     Open Access   (Followers: 14)
Arab Journal of Nephrology and Transplantation     Open Access   (Followers: 1)
Arabian Journal of Scientific Research / المجلة العربية للبحث العلمي     Open Access   (Followers: 1)
Archive of Biomedical Science and Engineering     Open Access   (Followers: 1)
Archive of Clinical Medicine     Open Access   (Followers: 1)
Archive of Community Health     Open Access   (Followers: 1)
Archives Medical Review Journal / Arşiv Kaynak Tarama Dergisi     Open Access  
Archives of Asthma, Allergy and Immunology     Open Access  
Archives of Clinical Hypertension     Open Access   (Followers: 2)
Archives of Medical and Biomedical Research     Open Access   (Followers: 3)
Archives of Medical Laboratory Sciences     Open Access   (Followers: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 5)
Archives of Medicine and Surgery     Open Access   (Followers: 1)
Archives of Organ Transplantation     Open Access   (Followers: 2)
Archives of Preventive Medicine     Open Access   (Followers: 3)
Archives of Pulmonology and Respiratory Care     Open Access   (Followers: 2)
Archives of Renal Diseases and Management     Open Access   (Followers: 2)
Archives of Trauma Research     Open Access   (Followers: 4)
Archivos de Medicina (Manizales)     Open Access   (Followers: 1)
ArgoSpine News & Journal     Hybrid Journal  
Arquivos Brasileiros de Oftalmologia     Open Access   (Followers: 1)
Arquivos de Ciências da Saúde     Open Access  
Arquivos de Medicina     Open Access   (Followers: 1)
Ars Medica : Revista de Ciencias Médicas     Open Access  
ARS Medica Tomitana     Open Access   (Followers: 1)
Art Therapy: Journal of the American Art Therapy Association     Hybrid Journal   (Followers: 19)
Arterial Hypertension     Open Access   (Followers: 1)
Artificial Intelligence in Medicine     Hybrid Journal   (Followers: 20)
Artificial Organs     Hybrid Journal   (Followers: 1)
ASHA Leader     Open Access   (Followers: 6)
Asia Pacific Family Medicine Journal     Open Access   (Followers: 4)
Asia Pacific Journal of Clinical Nutrition     Full-text available via subscription   (Followers: 13)
Asia Pacific Journal of Clinical Trials : Nervous System Diseases     Open Access   (Followers: 1)

        1 2 3 4 5 6 7 8 | Last

Similar Journals
Journal Cover
Advances in Traditional Medicine
Number of Followers: 8  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 2662-4052 - ISSN (Online) 2662-4060
Published by Springer-Verlag Homepage  [2626 journals]
  • The potential of Arum spp. as a cure for hemorrhoids: chemistry,
           bioactivities, and application
    • Abstract: Abstract Hemorrhoids become pathological when swollen or inflamed. They can be very painful and occasionally cause serious anemia as they often break and hardly heal. Orthodox medicine usually treats hemorrhoids through surgery combined with medication containing the flavonoid diosmin. Our previous ethnobotanical and ethnopharmacological research in Bulgaria (Balkan Peninsula) revealed that Arum maculatum and possibly its relatives were more efficient to cure hemorrhoids. The aim of this study is to review the traditional use, biologically active compounds and pharmacological activities of Arum species. Biologically active compounds identified in various parts of Arum species include: alkaloids, terpenoids, phenolic compounds as well as carbohydrate-binding proteins. Arum species extracts have analgesic, antimicrobial, anti-inflammatory and anticancer properties. According to ethnobotanical data, the most frequent biological activity of several Arum species which deserves special attention is against hemorrhoids and it is still poorly studied with modern pharmacological tests.
      PubDate: 2020-03-04
       
  • Neuroprotective effect of organic and inorganically grown tea on oxidative
           damage in rat model of Alzheimer’s disease
    • Abstract: Abstract Production of improved valued tea is in high demand due to its pharmacological properties against various neurodegenerative diseases like Alzheimer’s disease. In this study, an attempt was made to compare the protective effect of the tea grown under organic and inorganic nutrient management practices against intra-cerebroventricular (i.c.v) colchicine induced memory impairment and oxidative damage in rat model of Alzheimer’s disease (AD). Results showed that chronic intraperitoneal (i.p) administration of tea extract (20 mg/kg i.p) significantly improved the cognitive dysfunction and memory impairment in colchicine treated AD rat model. This beneficial effect occurred with an increase in α-secretase activity, Superoxide dismutase, Catalase activities, and a decrease in Acetylcholinesterase level, Aβ -42 level, Cox-2-linked neuro-inflammation by intraperitoneal injection of tea extract grown organically and inorganically. The amyloid Aβ concentration in the rat model of AD was 84 ± 1.7 pg/mg protein. With administration of tea extract, the amyloid Aβ concentration decreased significantly to 55 ± 1.5, 52 ± 1.3 and 49 ± 1.5 pg/mg protein with the field level management of inorganic, integrated and organic nutrients, respectively. In this study celecoxib (20 mg/kg i.p) is used as a reference standard. This study stated organic tea as a promising neuroprotective agent or adjuvant to prevent AD.
      PubDate: 2020-02-11
       
  • α-Glucosidase inhibitors from Duranta repens modulate p53 signaling
           pathway in diabetes mellitus
    • Abstract: Abstract Hydroalcoholic extract/fraction(s) and scutellarein, a previously reported phytoconstituent from Duranta repens were evaluated for their α-glucosidase inhibitory activity using in vitro method. The reported phytoconstituents were also screened as α-glucosidase inhibitor, probable cytotoxicity, ADMET profile, and side effects via in silico models. Further, probable gene expression profile and pathways involved in diabetes/diabetes complications were also screened. Similarly, network was constructed among α-glucosidase inhibitors, modulated proteins and respective pathways and docking study was performed using autodock4.0. Fraction rich in flavonoids was found to possess the highest α-glucosidase inhibitory activity and the mode of inhibition was uncompetitive. The predicted α-glucosidase inhibitors were less cytotoxic to normal cells with lower side effects compared to acarbose. Similarly, gene-set enrichment analysis identified p53 signaling pathway to be primarily modulated by majority of phytoconstituents. Further, docking study revealed scutellarein to have highest binding affinity with α-glucosidase enzyme. In conclusion, present study identified the fraction rich in flavonoids to possess highest α-glucosidase inhibitory activity and could modulate p53 signaling pathway in diabetic pathogenesis.
      PubDate: 2020-02-03
       
  • Peel extract of Trichosanthes dioica has the potential to ameliorate T 4
           -induced thyrotoxicosis and hyperglycemia in mice
    • Abstract: Abstract Peels of the vegetables are usually considered as kitchen wastes. This view may not hold true for all types of vegetable peels. In this investigation, we have primarily tested the unknown potential of Trichosanthes dioica (T. dioica) peel extract in L-thyroxin (L-T4)-induced thyrotoxicosis and hyperglycemia. Swiss albino male mice were made thyrotoxic by injecting pre-standardized dose of L-thyroxin (L-T4) for 12 days and in them the effects of test peel extract at 25 and 50 mg/kg for 15 consecutive days were investigated. At the end of the experiment the levels of serum thyroxin (T4) and triidothyronine (T3), glucose and hepatic 5′-monodeiodinase I (5′D1) activity, lipid peroxidation and antioxidants levels were determined. L-T4 treatment significantly increased the levels of both the thyroid hormones and 5′DI activity. Hepatic lipid peroxidation (LPO) was significantly increased with a decrease in the levels of antioxidants. Serum glucose level was also found to be significantly elevated. However, administration of test peel extract in the thyrotoxic animals significantly decreased the thyroid hormones concentrations, serum glucose level, hepatic 5′D1 activity and hepatic LPO; but increased the levels of the antioxidants suggesting that the test peel extract has the potential to ameliorate thyrotoxicosis, hyperglycemia and peroxidative process. The peel extract’s antioxidant activity was further exhibited by its free radical, 2, 2-diphenylpicrylhydrazyl (DPPH) and nitric oxide (NO) scavenging abilities. Total polyphenol and flavonoid contents of the test peel appeared to be associated to these beneficial effects.
      PubDate: 2020-01-27
       
  • Antimicrobial activity of endophytic fungi isolated from the mangrove
           plant Sonneratia apetala (Buch.-Ham) from the Sundarbans mangrove forest
    • Abstract: Abstract Endophytic fungi reside in the intercellular space of plant nourished by the plant. In return, they provide bioactive molecules which can play critical roles on plant defense system. Fifty six endophytes were isolated from the leaves, root, bark and fruits of Sonneratia apetala, a pioneer mangrove plant in the Sundarbans, Bangladesh. A total of 56 isolates were obtained and 12 different species within 8 genera were identified using morphological and molecular characteristics. Antimicrobial activity of ethyl acetate (EtOAc) and methanolic (MeOH) extracts of these 12 different species were analyzed by resazurin assay and the minimum inhibitory concentrations (MICs) were determined. The fungal extracts showed antimicrobial activities against more than one tested bacterium or fungus among 5 human pathogenic microbes, i.e. Escherichia coli NCTC 12241, Staphylococcus aureus NCTC 12981, Micrococcus lutus NCTC 7508, Pseudomonas aeruginosa NCTC 7508 and Candida albicans ATCC 90028. Overall, methanolic extracts showed greater activity than that of ethyl acetate extracts. Of the isolates identified, Colletotrichum gloeosporioides, Aspergillus niger and Fusarium equiseti were the most active isolates and showed activity against microorganisms under investigation. Methanolic extracts of C. gloeosporioides and A. niger showed the lowest MIC (0.0024 mg/mL) against P. aeruginosa. The study indicates that endophytic fungi isolated from S. apetala species possess potential antimicrobial properties, which could be further investigated.
      PubDate: 2020-01-09
       
  • Clary sage essential oil and its biological activities
    • Abstract: Abstract Salvia sclarea or “clary sage” is an aromatic plant that is used for various ailments especially among the women. The aim of this investigation was to evaluate the biological activities of clary sage oil with emphasis on its application in women health. The information of this study was extracted by key words of clary sage, S. sclarea, biological activities in references books and electronic resources. The results of investigation exhibited that the chemical composition of clary sage influenced from various ecological, geographical and environmental conditions, but linalool and linalyl acetate is known as main components of clary sage oil. Clary sage oil is used in aromatherapy for women during the menstrual cycle, childbirth and menopause. The modern clinical investigations confirmed the efficacy of clary sage oil as anti-stress, anti-depression and analgesic agents in primary dysmenorrhea. The anti-oxidant, antimicrobial, cytotoxic and anti-inflammatory effects of clary sage have been confirmed. Furthermore, clary sage oil is known as safe oil with no adverse effects. Designing the large clinical study to evaluate the oral efficacy of clary sage oil for women ailments is essential for future studies.
      PubDate: 2020-01-09
       
  • Anti-hypernociceptive effects of methanol extract of Boswellia dalzielii
           on STZ-induced diabetic neuropathic pain
    • Abstract: Abstract Painful neuropathy that can cause hyperalgesia and allodynia is the most common and debilitating complication of diabetes. Both hyperglycemia and oxidative stress clearly play a key role in the progression of diabetic neuropathy. The search for new natural products with combined anti-inflammatory, antioxidant, hypoglycemic and antinociceptive properties is important in the treatment of this disease. The purpose of this study was to evaluate the anti-hypernoceptive effect of the methanolic extract of Boswellia dalzielii in streptozotocin-induced diabetic mice. Thus, the mice were injected with 200 mg/kg of streptozotocin to produce hyperglycemia. Von Frey filaments, hotplate, acetone and formalin tests were used to evaluate anti-nociceptive activity. Assays of catalase, SOD, MDA and NO determined the antioxidant properties. When administered, methanolic extract of Boswellia dalzielii (250 and 500 mg/kg, p.o.) significantly reduced licking/biting behavior during the first and second phase of the formalin test in a dose-dependent manner. Moreover, this extract significantly improved the glycemia of diabetic mice, it also significantly decreased the levels of TNF alpha, IL-1 beta in the serum and the sciatic nerve, decreased the levels of MDA and NO, and then increased the activity of SOD and catalase enzymes. Our results suggest that methanolic extract of Boswellia dalzielii can be a useful therapeutic agent, presumably for both prevention and reversal of pathophysiologic pain. This effect seems to imply hyperglycemic and antioxidant properties of this plant.
      PubDate: 2020-01-09
       
  • Pyrrolidine alkaloids and their promises in pharmacotherapy
    • Abstract: Abstract This review aimed at summarizing the literature pertaining to the biological activities of pyrrolidine alkaloids and their derivatives obtained from various sources. For this purpose, an up-to-date search was made in various databases such as PubMed, Science Direct, Web of Science, Scopus, The American Chemical Society and Google Scholar. Findings suggest that to date, a number of pyrrolidine alkaloids have been shown to possess several important biological activities, including antioxidant, anti-inflammatory, antibacterial, antifungal, antiparasitic and anthelmintic, anticancer, anti-hyperglycemic, organ protective, and neuropharmacological activities. Additionally, some alkaloids have been identified to exert toxic effects on the animal organs. Among these alkaloids, bgugaine and irniine are known to cause renal injuries, whereas nicotine and cocaine have been confirmed to cause neurotoxicity in experimental animals. Furthermore, pyrrolidine alkaloids can be some of the best sources of pharmacologically active lead compounds.
      PubDate: 2020-01-09
       
  • Phenolic profiling and anti-Alzheimer’s evaluation of Eremobium
           aegyptiacum
    • Abstract: Abstract The Eremobium aegyptiacum (Spreng.) Schweinf.et Asch.ex Boiss aqueous extract (EAAE) was subjected to phytochemical investigation using LC–ESI–MS analysis. Twenty-seven compounds (one organic acid, two phenolic acids and twenty-four flavonoids) were characterized and tentatively identified. Among the detected compounds, acyl triglycoside derivatives of kaempferol and isorhamnetin are identified in the current study by using LC–MS technique for the first time from this species. EAAE was evaluated for its anti-Alzheimer activity. EAAE dose (156 mg/kg bw/day) was administrated for 6 weeks orally to female adult rats prior treated with AlCl3 (50 mg/Kg b.wt) to induce Alzheimer disease. AChE level, lipid profile (TC, TG and LDL-C) levels, reduced glutathione (GSH) and malondialdehyde (MDA) levels were investigated. EAAE exhibited significant reduction in AChE level (58.57 ± 9 µMSH/min/mg protein) in comparison with AlCl3 group (97.88 ± 9.87 µMSH/min/mg protein). Also, GSH level was increased to 100.09 ± 25.51 mg/g tissue and MDA level was decreased to 1.26 ± 0.1 µmol/g tissue, compared to AlCl3 rats (57.05 ± 12.56 mg/g tissue and 1.96 ± 0.29 µmol/g tissue, respectively). Additionally, lipid profile (TC, TG, LDL-C) levels were significantly reduced to 35.15 ± 4.74, 18.16 ± 3.07 and 35.75 ± 4.17 µmol/g tissue, in comparison with AlCl3 group (65.20 ± 5.54, 27.93 ± 3.51 and 63.84 ± 6.98, respectively). Briefly, EAAE succeeded in amelioration of the increased AChE activity and the antioxidant activity which considered as an important defense mechanism to control the brain injury in AlCl3 rats. This amelioration was parallel to its effect on total cholesterol triglycerides and LDL levels.
      PubDate: 2020-01-06
       
  • Comparative pharmacologic profiles of leaves and hypocotyls of a mangrove
           plant: Bruguiera gymnorrhiza
    • Abstract: Abstract Ethanolic extracts of leaves and hypocotyls of a mangrove plant, Bruguiera gymnorrhiza (Family Rhizophoraceae), were investigated to identify the presence of different phytochemicals and to assess the antihyperglycemic, antidiarrheal, analgesic and antioxidative activity in the current study. Oral glucose tolerance test (OGTT) was performed to investigate the in vivo antihyperglycemic activity and leaves extract (LE) was found to possess significant antihyperglycemic property compared to hypocotyl extract (HE). Therefore, the leaves extract was considered for α-Glucosidase enzyme inhibitory activity test and substantial α-glucosidase enzyme inhibitory property was observed with an IC50 (concentration required to inhibit 50% enzyme) value of 2.670. Antioxidative activity of plant extracts was tested in vitro by evaluating their ability to scavenge DPPH, hydrogen peroxide and hydroxyl radical as well as superoxide anions. In all cases, LE showed greater activity than HE. In addition, LE demonstrated higher amount of total phenolics, flavonoids and tannins indicating higher antioxidant effect compared to HE. For the evaluation of antidiarrheal effect in castor oil induced diarrheal mice, both extracts showed significant inhibition of defecation at doses 250 and 500 mg/kg body weight. Finally, for acetic acid-induced writhing method to evaluate the analgesic activity, significant percentage inhibition of writhing (P < 0.05 vs. control) was observed for both extracts at lower and higher doses. Altogether, these studies justified the plant’s usage in folklore medication.
      PubDate: 2020-01-03
       
  • Characterization of α-glucosidase inhibitory activity of Tetracera
           scandens leaves by Fourier transform infrared spectroscopy-based
           metabolomics
    • Abstract: Abstract Tetracera scandens is a medicinal shrub that belongs to Dilleniaceae. The leaves of the plant have been traditionally used in the treatment of diabetes mellitus in Malaysia. The conventional quality control analysis of medicinal plants that relies on the quantification of few major metabolites is considered time-consuming since it requires extensive sample preparation and neglects the possible impacts that the minor metabolites could have on the activity. This study was aimed to investigate the α-glucosidase inhibitory (AGI) potential of different hydromethanolic extracts of T. scandens leaves and to establish a predictive multivariate model that could be used for the quality evaluation of T. scandens leaf based on the Fourier transform infrared (FT-IR) spectra of its extracts. Different solvent ratios (0%, 20%, 40%, 60%, 80% and 100% methanol in water) were used to prepare a total of 36 extracts. The AGI potential and the FT-IR fingerprint spectrum were acquired for each extract. A four components orthogonal partial least squares (OPLS) model (1 + 3 + 0) with R2Y of 0.951 and Q2Y of 0.916 was established to describe the correlation between the fingerprint FT-IR spectra of different T. scandens extracts and their corresponding AGI activities. The carbon-halide, carbon–oxygen single bonds, as well as the hydroxyl and carbonyl groups were identified to be positively correlated with the AGI activity. To sum up, an OPLS model was successfully developed as a rapid quality evaluation method to predict the AGI activity of T. scandens.
      PubDate: 2019-12-23
       
  • In vitro and in silico studies of the antifungal properties of the bulb
           and leaves extracts of Drimia delagoensis Baker (Jessop)
    • Abstract: Abstract Drimia delagoensis (D. delagoensis), a member of the Hyacinthaceae family, is commonly used for the treatment of heartwater and skin ailments by the Zulus in South Africa. In this research study, the bulb and leaves of D. delagoensis were tested for their antifungal efficacy against Aspergillus fumigatus. Eight crude extracts were further analysed to determine the volatile chemical components of the plant using one-dimensional gas chromatography coupled with the time of fight mass spectrometry. The compounds detected from GC-MS were further subjected to molecular docking study to determine prospective relationship between the analysed compounds (1–9) and the active site of the glucosamine-6-phosphate synthase. All the crude extracts were effective against A. fumigatus. However, it was observed that dichloromethane: methanol (1:1) mixture for the bulb extracts had a high minimum fungal concentration values of (7.8 µg/mL) followed by hexane (7.8 µg/mL) and ethyl acetate (7.8 µg/mL). Compounds (9Z,12Z)-9,12-Octadecadienoic acid(R)-2,3-bis[[(E)-2-methyl-2-butenoyl]oxy]propyl ester and 9-Octadecenoic acid (9Z)-,1-methyl-1,2-ethanediyl ester had higher binding affinities of − 47.69 and − 62.36 kcal/mol, respectively when compared to amphotericin B standard drug (− 44.19 kcal/mol). Furthermore, lipophilicity values for ligands, which ranged from − 11.46 to − 27.07, were more significant than those for amphotericin B (− 19.66), and this greater significance could also be ascribed to the potency of the crude extracts against A. fumigatus.
      PubDate: 2019-12-20
       
  • Neuroprotective effect of Salvia splendens extract and its constituents
           against AlCl 3 -induced Alzheimer’s disease in rats
    • Abstract: Abstract Salvia splendens is a species of the genus Salvia that is known for its neuro-therapeutic properties. The present study aimed to investigate the effect of two fractions from the methanolic extract of the aerial parts of S. splendens cultivated in Egypt, the petroleum ether-soluble (PES) and n-butanol-soluble (BS) fractions, against AlCl3-induced Alzheimer’s disease (AD) in rats. Rats treated with AlCl3 (100 mg/kg b.wt. p.o.) for 4 weeks developed behavioral, biochemical and histological changes similar to that of AD. Behavioral deficits were assessed by T-maze test and percentage changes in oxidative stress and AD markers in brain. Extent of DNA damage and histopathological changes were also evaluated. Results revealed that both fractions; PES and BS (at dose of 500 mg/kg b.wt), significantly attenuated AlCl3-induced behavioral impairment in rats. This effect was accompanied by acetylcholinesterase (AChE) activity inhibition (53.18% and 68.66%, respectively), and Aβ deposition reduction (33.3% and 34.3%, respectively). Both fractions markedly decreased oxidative stress markers level (lipid peroxide, protein carbonyl, reduced glutathione and nitric oxide), and inhibited catalase and caspase-3 activities. Also, the content of noradrenaline, adrenaline, 5-HT and dopamine were significantly increased. The fractions preserved the histo-architecture pattern of the hippocampus and cortex from the AlCl3-induced damage. Bioactivity-guided fractionation led to the isolation of two sterols; β-sitosterol and β-sitosterolpalmitate from PES fraction, and 6 phenolic compounds (acacetin, chrysoeriol, apigenin, luteolin, rosmarinic acid and caffeic acid) from BS fraction. Rosmarinic acid and caffeic acid significantly inhibited AChE in vitro (IC50 values of 0.398 mg/mL and 0.327 mg/mL, respectively) compared to physostigmine (IC50 0.227 mg/mL). The BS fraction is standardized (HPLC–DAD) to contain not less than 0.0254% (w/w)of rosmarinic acid and 0.0129% (w/w) of caffeic acid. These findings suggest that S. splendens is beneficial in attenuating AlCl3-induced neurotoxicity in rats.
      PubDate: 2019-12-20
       
  • Valorization and identification of bioactive compounds of a spice
           Ammodaucus leucotrichus
    • Abstract: Abstract Ammodaucus leucotrichus Cosson & Durieu is a spice largely used in traditional medicine in North African countries especially in Algerian Sahara. This study was conducted to identify the phenolic compounds of aerial parts organic extracts and also to evaluate their in vitro antioxidant and antimicrobial activities. The antioxidant activity was assessed by three methods: DPPH reducing activity, ferric reducing power and phosphomolybdate method. The antimicrobial activity was assessed against fifteen pathogen reference microbial strains using Agar diffusion and broth microdilution assays. HPLC analysis allowed the identification of two flavonoids (naringenin and quercetin), three phenolic acids (sinapic, ferulic and p-coumaric) and vanillin. It was found that the highest abundance in polyphenol, flavonoid and flavonol contents and also the strongest antioxidant activities were recorded in the ethyl acetate and n-butanol fractions with IC50 for DPPH assay of 30 ± 1.4 µg/mL, EC50 for FRAP assay of 24 ± 1.1 µg/mL and a reductive activity on phosphomolybdate of 134.79 ± 1.8 µg AAE/mg. The extracts showed a broad spectrum of antimicrobial activities for the most tested microorganisms with inhibition zones ranging from 7 to 10 mm and MIC values ranging from 3.125 to 25 mg/mL. The most interesting activities were attributed to the ethyl acetate fractions notably against Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Listeria monocytogenes, Acinetobacter baumannii and Micrococcus luteus. These results pointed out that A. leucotrichus exhibit an appreciable antibacterial and antioxidant activities which are probably due to the wide range, the high contents of phenolic classes of secondary metabolites detected and the synergistic interactions between them.
      PubDate: 2019-12-17
       
  • Aster yomena has anti-arthritic activity against septic arthritis induced
           by Candida albicans : its terpenoid constituent is the most effective and
           has synergy with indomethacin
    • Abstract: Abstract In recent, various pharmacological activities of Aster yomena have been determined, but its anti-arthritic activity remains unknown until now. The aim of the present study was to investigate whether A. yomena has anti-arthritic activity against septic arthritis caused by Candida albicans, a major etiological agent causing septic arthritis. In experiments, three types of A. yomena extracts such as 70% ethanol extract (EEAY) and its n-buthanol fraction (BuF) and ethyl acetate fraction (EAF) were tested. The color tests and the GC–MS analysis revealed that BuF and EAF contained terpenoid and polyphenolic, respectively. Results from the anti-inflammatory tests showed that BuF-activity at 50 μg/ml was closely equivalent to EEAY- or EAF-activity at 500 μg/ml, indicating that BuF was 10 times more potent than EAF and EEAY. In the mouse model of the arthritis, the footpad swelling of BuF (100 μg/mouse/time)-, and EEAY(1000 μg/mouse/time)-, and indomethacin (IMC; 30 μg/mouse/time)-treated mice groups decreased at a similar rate until the end of the observation. At Day 9, the highest peak of arthritic induction, there were app. 15.4%, 27.8%, and 48.2%—reductions of footpad swelling, corresponding to IMC-, BuF-, or EEAY-treatment, respectively. In terms of dosage comparison, the BuF effectiveness was assessed to be 10 folds more efficient than EEAY effectiveness. When compared to IMC potency, the BuF potency was almost twice more effective than the IMC. EAF’s anti-arthritic activity was alternatively determined because of its killing of test mice. The determination was done if EAF contains chlorogenic acid (CRA), which is known to have such anti-arthritic activity (Lee et al. in Int Immunopharmacol 8:1681–1685, 2008). The HPLC analysis revealed EAF contained CRA, a polyphenolic. This indicates CRA in EAF could be involved in the activity. BuF, the most effective extract, had synergy with IMC, a clinically available anti-inflammatory agent. The BuF synergism was exhibited at 12.5 time lower dose of EEAY in a similar pattern as EEAY was. In conclusion, for the first time, we provide insights into the potential of A. yomena against the septic arthritis. The terpenoid constituent is the most effective for the anti-arthritic activity and for synergy with IMC.
      PubDate: 2019-12-12
       
  • Toxological evaluation of Cyperus compressus Linn., a traditionally used
           anthelmintic plant in India
    • Abstract: Abstract This study reports the toxicological evaluation findings of Cyperus compressus Linn., (Cyperaceae), whose root decoction is used in India to treat the intestinal helminthic infestations. The acute oral toxicity (AOT) of C. compressus root extract (CRE) was conducted in Swiss mice, following OECD guidelines 407. The sub-acute toxicity study of CRE was undertaken in Wistar rats, using three doses viz., 175, 350 and 700 mg/kg, involving haematological, biochemical and transmission electron microscopy (TEM) parameters. AOT study revealed the median lethal dose of CRE to be above 2000 mg/kg. The sub-acute study of CRE revealed elevated levels of serum glutamic oxaloacetic transaminase in male rats, only in high extract-treated group, but the serum glutamic pyruvic transaminase was found to be elevated both in male and female animals. TEM studies of kidney and liver of animals also revealed considerable deformities in the nucleus and mitochondria in the form of damages to nuclear membrane, cristae and to double layered membrane of mitochondria, only in the high-extract treated group of animals. The root decoction of C. compressus show presence of toxicity in the highest dose tested animals. Therefore, the use of this plant extract against intestinal helminthiasis raises concerns about its safety.
      PubDate: 2019-12-09
       
  • Syzygium aromaticum L.: phytochemical investigation and comparison of the
           scavenging activity of essential oil, extracts and eugenol
    • Abstract: Abstract Syzygium aromaticum L. is a popular flavor and fragrance spice used in cooking, traditional and modern therapy. No work has compared between the scavenging capacity of the essential oil, extracts and eugenol, or studied that of the hexane extract, as well as its phenolic and flavonoid contents. To reveal more details on phytochemical and scavenging characteristics of Syzygium aromaticum spice, we estimated the scavenging activity of the essential oil, each extract of water, ethanol, ethyl acetate and hexane obtained from clove buds, based on their effective concentration able to scavenge 50% (EC50) of 2,2′-diphenyl-1-picrylhydrazyl, and 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt free radicals. The essential oil showed high scavenging activity (EC50 of 0.40 ± 0.06 and 0.42 ± 0.02 mg/ml), and comprises 13 identified compounds. Eugenol, β-Caryophyllene, eugenyl acetate and α-Humulene are the major components. Comparing extracts, those of ethanol and hexane exhibited the greatest phenolic content (351.83 ± 17.90 and 348.04 ± 24.54 mg of gallic acid equivalent/gextract respectively) and the potent scavenging activities (EC50 of 0.41 ± 0.03 and 0.37 ± 0.00 mg/ml respectively). A moderate flavonoid content was observed, and aqueous extract was the best (21.90 ± 0.16 mg of quercetin equivalent/gextract). According to thin layer chromatography screening, all extracts content eugenol except that of water, this phenol contributes mainly on the scavenging activity and seems to be more active in mixture with terpenes, like in essential oil.
      PubDate: 2019-12-06
       
  • Historical perspective of Algerian pharmacological knowledge
    • Abstract: Abstract Many studies have initiated the use of plant species in traditional Algerian medicine taking into consideration that the Algerian flora is the main source of traditional remedies. In fact, Algerian ethnopharmacology was a combination of ancient knowledge inherited from Islamic civilization and purely empirical uses of substances of different origins; plant, animal and inorganic. The study showed the existence of non-systematic knowledge of plants oriented by knowledge in classical medicine and the use of a large number of ingredients separately or in mixture according to very diverse therapeutic formulas. This study presented the different uses of 134 substances of plant origin, 13 of animal origin and 12 of inorganic origin; these substances have enriched among others the Algerian pharmacopoeia in the eighteenth and nineteenth centuries.
      PubDate: 2019-12-05
       
  • Exploring the bioactive compounds from endophytic bacteria of a medicinal
           plant: Ephedra foliata (Ephedrales: Ephedraceae)
    • Abstract: Abstract To explore the role of endophytic bacteria from a medicinal plant in the production of bioactive compounds, bacterial strains (10 different taxa) were isolated from the surface sterilized stem of healthy Ephedra foliata. The endophytes were related to Firmicutes, Actinobacteria and Proteobacteria. They were identified as members of Bacillus (5 strains), Paenibacillus (2 strains), Brevundimonas (1 strain), Kytococcus (1 strain), and Microbacterium (1 strain). The bacterial metabolites were extracted by chloroform and examined for antimicrobial, antioxidant and anticancer properties. Strain F5 (Paenibacillus) showed moderate antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli. Its antibacterial activity was enhanced 2.3 times in the optimum conditions (starch 1% w/v, malt extract 0.2% w/v, pH 7, temperature 30 °C, inoculum size 3% v/v, and 48 h incubation time, at the basal tryptic soy broth medium). The highest DPPH scavenging capacity (EC50 at 43.0 µg/ml) was observed by the extract of the strain A1 (Microbacterium). The highest cytotoxic activity on HeLa cancerous cell was related to the extract obtain from strain A3 (Kytococcus) and its IC50 values were determined as (µg/ml) 104, 64, and 43 after 24, 48, and 72 h, respectively. Chemical identification of the extracts by tandem mass spectrometry revealed possible presence of alkaloid, aminoglycoside, flavonoid, and terpenoid compounds as previously extracted from other medicinal plants. Our results show the great potential of these endophytes for production of plant-related bioactive compounds.
      PubDate: 2019-12-04
       
  • Ligand-based virtual screening, consensus molecular docking, multi-target
           analysis and comprehensive ADMET profiling and MD stimulation to find out
           noteworthy tyrosine kinase inhibitor with better efficacy and accuracy
    • Abstract: Abstract Inhibition of BCR–ABL tyrosine kinase plays a crucial role in the management of chronic myelogenous leukemia (CML). The suppression of CML is getting harder because of a distinct pattern of resistance. Developing new types of ABL tyrosine kinase inhibitors along with ABL2, CSF1R, KIT, LCK, PDGFRA, and PDGFRB inhibitors is the main objective of this study that may overcome the drug resistance issue. The current study has been conducted using a kinase database containing 177,000 bioactive molecules, the top 135 molecules were selected with the best docking score and subjected to comprehensive ADMET profiling, multi-target analysis. Based on consensus molecular docking score (AutoDock, Chimera, Achilles, and Mcule), 22 molecules have been screened out which later undertaken for ADME/T profiling. After profiling of ADME/T data, selected molecules subjected to docking with multiple targets. Finally, molecular dynamics simulations had performed to screen the binding accuracy of the four lead molecules with ABL1. MD simulations of the desired complex (ABL1, ABL2, CSF1R, KIT, LCK, PDGFRA, and PDGFRB, among them ABL1 was the prime target) performed and found that PCID 10181160 and PCID 72724706 are the most promising inhibitors comparing to imatinib. These lead molecules are the potential CML inhibitors that could resolve the resistance pattern. Further chemical synthesis, wet lab analysis, and experimental validation deserve the utmost attention.
      PubDate: 2019-12-04
       
 
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