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MEDICAL SCIENCES (2268 journals)            First | 1 2 3 4 5 6 7 8 | Last

Showing 201 - 400 of 3562 Journals sorted alphabetically
Audiology - Communication Research     Open Access   (Followers: 10)
Auris Nasus Larynx     Full-text available via subscription  
Australasian Journal of Ultrasound in Medicine (AJUM)     Hybrid Journal  
Australian Coeliac     Full-text available via subscription   (Followers: 1)
Australian Family Physician     Full-text available via subscription   (Followers: 3)
Australian Journal of Medical Science     Full-text available via subscription   (Followers: 2)
Autopsy and Case Reports     Open Access  
Avicenna     Open Access   (Followers: 3)
Avicenna Journal of Clinical Medicine     Open Access  
Avicenna Journal of Medicine     Open Access   (Followers: 1)
Bangabandhu Sheikh Mujib Medical University Journal     Open Access   (Followers: 1)
Bangladesh Journal of Anatomy     Open Access   (Followers: 2)
Bangladesh Journal of Bioethics     Open Access  
Bangladesh Journal of Medical Biochemistry     Open Access   (Followers: 4)
Bangladesh Journal of Medical Education     Open Access   (Followers: 2)
Bangladesh Journal of Medical Microbiology     Open Access   (Followers: 4)
Bangladesh Journal of Medical Physics     Open Access   (Followers: 1)
Bangladesh Journal of Medical Science     Open Access  
Bangladesh Journal of Medicine     Open Access   (Followers: 1)
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Bangladesh Journal of Scientific Research     Open Access   (Followers: 1)
Bangladesh Medical Journal     Open Access  
Bangladesh Medical Journal Khulna     Open Access  
Basal Ganglia     Hybrid Journal  
Basic Sciences of Medicine     Open Access   (Followers: 2)
Batı Karadeniz Tıp Dergisi / Medical Journal of Western Black Sea     Open Access  
Baylor University Medical Center Proceedings     Hybrid Journal  
BBA Clinical     Open Access  
BC Medical Journal     Free  
Benha Medical Journal     Open Access  
Beni-Suef University Journal of Basic and Applied Sciences     Open Access   (Followers: 4)
Bijblijven     Hybrid Journal  
Bijzijn     Hybrid Journal   (Followers: 1)
Bijzijn XL     Hybrid Journal  
Bio-Algorithms and Med-Systems     Hybrid Journal   (Followers: 2)
BioDiscovery     Open Access   (Followers: 2)
Bioelectromagnetics     Hybrid Journal   (Followers: 2)
Bioelectronic Medicine     Open Access   (Followers: 1)
Bioengineering & Translational Medicine     Open Access  
Bioethics     Hybrid Journal   (Followers: 17)
Bioethics Research Notes     Full-text available via subscription   (Followers: 14)
Biologics in Therapy     Open Access  
Biology of Sex Differences     Open Access   (Followers: 2)
Biomarker Research     Open Access   (Followers: 3)
Biomarkers in Medicine     Hybrid Journal   (Followers: 2)
BioMed Research International     Open Access   (Followers: 4)
Biomédica     Open Access  
Biomedical & Life Sciences Collection     Full-text available via subscription   (Followers: 3)
Biomedical and Biotechnology Research Journal     Open Access   (Followers: 1)
Biomedical Engineering     Hybrid Journal   (Followers: 17)
Biomedical Engineering and Computational Biology     Open Access   (Followers: 13)
Biomedical Engineering Letters     Hybrid Journal   (Followers: 6)
Biomedical Engineering Research     Open Access   (Followers: 7)
Biomedical Informatics Insights     Open Access   (Followers: 8)
Biomedical Journal     Open Access   (Followers: 3)
Biomedical Materials     Hybrid Journal   (Followers: 7)
Biomedical Microdevices     Hybrid Journal   (Followers: 8)
Biomedical Optics Express     Open Access   (Followers: 6)
Biomedical Photonics     Open Access  
Biomedical Reports     Full-text available via subscription  
Biomedical Research Reports     Full-text available via subscription   (Followers: 2)
Biomedical Safety & Standards     Full-text available via subscription   (Followers: 8)
Biomedical Science and Engineering     Open Access   (Followers: 7)
BioMedicine     Open Access  
Biomedicine Hub     Open Access  
Biomedicines     Open Access   (Followers: 1)
Biomedika     Open Access  
Biomolecular and Health Science Journal     Open Access   (Followers: 1)
Biophysics Reports     Open Access  
BioPsychoSocial Medicine     Open Access   (Followers: 8)
Biosalud     Open Access  
Biostatistics & Epidemiology     Hybrid Journal   (Followers: 1)
Birat Journal of Health Sciences     Open Access  
BIRDEM Medical Journal     Open Access   (Followers: 1)
Birth Defects Research     Hybrid Journal  
Birth Defects Research Part A : Clinical and Molecular Teratology     Hybrid Journal   (Followers: 3)
Birth Defects Research Part C : Embryo Today : Reviews     Hybrid Journal  
BJR|Open     Open Access  
BJS Open     Open Access   (Followers: 1)
Black Sea Journal of Health Science     Open Access  
BLDE University Journal of Health Sciences     Open Access  
Blickpunkt Medizin     Hybrid Journal  
BMC Biomedical Engineering     Open Access  
BMC Medical Ethics     Open Access   (Followers: 21)
BMC Medical Research Methodology     Open Access   (Followers: 9)
BMC Medicine     Open Access   (Followers: 13)
BMC Obesity     Open Access   (Followers: 8)
BMC Proceedings     Full-text available via subscription   (Followers: 1)
BMC Research Notes     Open Access   (Followers: 4)
BMC Sports Science, Medicine and Rehabilitation     Open Access   (Followers: 34)
BMH Medical Journal     Open Access   (Followers: 2)
BMI Journal : Bariátrica & Metabólica Iberoamericana     Open Access  
BMJ     Hybrid Journal   (Followers: 1743)
BMJ Case Reports     Hybrid Journal   (Followers: 26)
BMJ Evidence-Based Medicine     Hybrid Journal   (Followers: 2)
BMJ Global Health     Open Access   (Followers: 3)
BMJ Innovations     Hybrid Journal   (Followers: 6)
BMJ Leader     Hybrid Journal  
BMJ Open     Open Access   (Followers: 42)
BMJ Open Quality     Open Access   (Followers: 19)
BMJ Open Science     Open Access   (Followers: 1)
BMJ Sexual & Reproductive Health     Hybrid Journal   (Followers: 2)
BMJ Surgery, Interventions, & Health Technologies     Open Access  
Bodine Journal     Open Access  
Boletín del Consejo Académico de Ética en Medicina     Open Access  
Boletín del ECEMC     Open Access  
Boletin Médico de Postgrado     Open Access  
Boletín Médico del Hospital Infantil de México     Open Access  
Bone     Hybrid Journal   (Followers: 18)
Bone and Tissue Regeneration Insights     Open Access   (Followers: 2)
Bone Marrow Research     Open Access   (Followers: 2)
Bone Reports     Open Access  
Bosnian Journal of Basic Medical Sciences     Open Access  
Bozok Tıp Dergisi / Bozok Medical Journal     Open Access  
Brachytherapy     Full-text available via subscription   (Followers: 6)
Brain and Development     Full-text available via subscription   (Followers: 5)
Brain Connectivity     Hybrid Journal   (Followers: 5)
Brain Impairment     Full-text available via subscription   (Followers: 2)
Brazilian Journal of Medical and Biological Research     Open Access  
Brazilian Journal of Medicine and Human Health     Open Access  
Brazilian Journal of Pain (BrJP)     Open Access  
Brazilian Journal of Physical Therapy     Open Access   (Followers: 1)
Breastfeeding Review     Full-text available via subscription   (Followers: 18)
British Journal of Biomedical Science     Full-text available via subscription   (Followers: 7)
British Journal of General Practice     Full-text available via subscription   (Followers: 38)
British Journal of Hospital Medicine     Full-text available via subscription   (Followers: 16)
British Medical Bulletin     Hybrid Journal   (Followers: 6)
Buddhachinaraj Medical Journal     Open Access  
Bulletin Amades     Open Access  
Bulletin de la Société de pathologie exotique     Hybrid Journal   (Followers: 1)
Bulletin of Legal Medicine     Open Access  
Bulletin of Medical Sciences     Open Access  
Bulletin of the History of Medicine     Full-text available via subscription   (Followers: 18)
Bulletin of the Menninger Clinic     Full-text available via subscription  
Bulletin of The Royal College of Surgeons of England     Free  
Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products     Open Access  
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz     Hybrid Journal   (Followers: 6)
Burapha Journal of Medicine     Open Access  
Burns     Hybrid Journal   (Followers: 10)
Cadernos de Naturologia e Terapias Complementares     Open Access   (Followers: 1)
Calcified Tissue International     Hybrid Journal   (Followers: 2)
Canadian Bulletin of Medical History     Hybrid Journal  
Canadian Family Physician     Partially Free   (Followers: 13)
Canadian Journal of Pain     Open Access   (Followers: 2)
Canadian Journal of Rural Medicine     Full-text available via subscription   (Followers: 1)
Canadian Medical Association Journal     Open Access   (Followers: 17)
Canadian Medical Education Journal     Open Access   (Followers: 10)
Canadian Prosthetics & Orthotics Journal     Open Access  
Cannabis and Cannabinoid Research     Hybrid Journal   (Followers: 1)
Cardiac Electrophysiology Clinics     Full-text available via subscription   (Followers: 1)
Care Management Journals     Hybrid Journal   (Followers: 5)
Case Reports     Open Access  
Case Reports in Acute Medicine     Open Access  
Case Reports in Clinical Medicine     Open Access   (Followers: 1)
Case Reports in Clinical Nutrition     Open Access   (Followers: 1)
Case Reports in Medicine     Open Access   (Followers: 2)
Case Reports in Transplantation     Open Access  
Case Reports in Vascular Medicine     Open Access  
Case Reports in Women's Health     Open Access   (Followers: 4)
Case Study and Case Report     Open Access   (Followers: 5)
CBU International Conference Proceedings     Open Access   (Followers: 3)
Cell & Bioscience     Open Access   (Followers: 6)
Cell Adhesion & Migration     Open Access   (Followers: 9)
Cell and Molecular Response to Stress     Full-text available via subscription   (Followers: 2)
Cell and Tissue Transplantation and Therapy     Open Access   (Followers: 2)
Cell Cycle     Full-text available via subscription   (Followers: 6)
Cell Death and Differentiation     Hybrid Journal   (Followers: 7)
Cell Death Discovery     Open Access   (Followers: 1)
Cell Health and Cytoskeleton     Open Access   (Followers: 1)
Cell Medicine     Open Access   (Followers: 6)
Cell Research     Hybrid Journal   (Followers: 8)
Cell Transplantation     Open Access   (Followers: 4)
CEN Case Reports     Hybrid Journal  
Central African Journal of Medicine     Full-text available via subscription  
Ceylon Journal of Medical Science     Open Access  
Ceylon Medical Journal     Open Access  
Chattagram Maa-O-Shishu Hospital Medical College Journal     Open Access  
Chiang Mai Medical Journal     Open Access  
ChiangRai Medical Journal     Open Access  
Chimerism     Full-text available via subscription  
Chinese Journal of Integrative Medicine     Hybrid Journal   (Followers: 3)
Chinese Journal of Natural Medicines     Full-text available via subscription   (Followers: 1)
Chinese Medical Journal     Open Access   (Followers: 10)
Chinese Medical Record English Edition     Hybrid Journal  
Chinese Medical Sciences Journal     Full-text available via subscription   (Followers: 2)
Chinese Medicine     Open Access   (Followers: 2)
Chinese Medicine     Open Access   (Followers: 4)
Chisholm Health Ethics Bulletin     Full-text available via subscription   (Followers: 1)
CHRISMED Journal of Health and Research     Open Access   (Followers: 2)
Christian Journal for Global Health     Open Access  
Chronic Diseases and Translational Medicine     Open Access  
Chronic Illness     Hybrid Journal   (Followers: 6)
Chronic Wound Care Management and Research     Open Access   (Followers: 4)
Chronobiology International     Hybrid Journal   (Followers: 3)
ChronoPhysiology and Therapy     Open Access  
Chulalongkorn Medical Bulletin     Open Access  
Chulalongkorn Medical Journal     Open Access  
Ciencia e Innovación en Salud     Open Access  
Ciencia e Investigación Medico Estudiantil Latinoamericana     Open Access  
Ciencias Clínicas     Open Access  

  First | 1 2 3 4 5 6 7 8 | Last

Similar Journals
Journal Cover
Chulalongkorn Medical Journal
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2651-2343 - ISSN (Online) 2651-0812
Published by Chulalongkorn University Homepage  [11 journals]
  • Celebrating the 72nd Anniversary of Faculty of Medicine, Chulalongkorn
           University

    • Authors: Sittisak Honsawek
      Pages: 65 - 65
      Abstract: It is remarkable to be celebrating the 72nd anniversary of the Faculty of Medicine, Chulalongkorn University, which was established in 1947 in accordance with the royal principles of HM King Ananda Mahidol (RAMA VIII) to develop outstanding and selfless individuals to benefit all mankind. Together, this triad of excellence is known all over the world as the country’s most robust and progressive medical network. In addition, the royal wishes aspired to educate a sufficient number of medical doctors to provide better health care for Thai people and satisfy the public’s demands. The Faculty of Medicine was found in King Chulalongkorn Memorial Hospital, the Thai Red Cross Society and was officially opened on June 11, 1947. With over seven decades of experience and international collaborations, our strong medical heritage anchors our efforts to propel our program into uncharted frontiers medicine. To this day, the Faculty, Hospital, and Red Cross Society remain the pillars of the community, constantly leading the way in medical training and healthcare excellence.
      PubDate: 2019-01-29
      Issue No: Vol. 63, No. 2 (2019)
       
  • Antimicrobial resistance patterns of bacterial colonization in urine of
           patients with spinal cord lesion admitted at Thai Red Cross Rehabilitation
           Center

    • Authors: Sutunchalee Sikanjananun, Sirikwan Panyasriwanit, Wasuwat Kitisomprayoonkul, Chusana Suankrata, Natthiya Tantisiriwat
      Pages: 67 - 72
      Abstract: Background: The emergence of extended spectrum beta-lactamase (ESBL)-producing Escherichia coli and
      Klebsiella pneumoniae at the stand-alone Rehabilitation Center of the Thai Red Cross Society has become a
      concern for treatment of patients with neurogenic bladder. Objective: To identify commonly observed bacterial colonization in urine of patients with spinal cord lesions. Methods: Medical records of all 135 patients with spinal cord lesions and who were admitted to the Thai Red Cross Rehabilitation Center were retrospectively reviewed for demographic data, type of neurogenic bladder and bladder management, and common bacterial colonization in urine specimens with antimicrobial susceptibility reports. Results: Of the 135 spinal cord lesion patients, 100 were male with the median age of 47 years old: 85% of them had neurogenic bladder, 39.8% detrusor overactivity (DO), 35% DO with detrusor sphincter dyssynergia, 24.3% detrusor underactivity, and 1% mixed type. Escherichia coli was the most frequent isolate followed by
      Klebsiella pneumoniae. Both E. coli and K. pneumoniae were multidrug-resistant (MDR) strains: 100% resistant
      to penicillin, fluoroquinolones (FQ), trimethoprim/ sulfamethoxazole (TMP-SMZ), and amoxicillin-clavulanic acid (AMC); 66.7% resistant to cephalosporin; 28.6% resistant to carbapenems; and, 28.6% resistant to aminoglycosides. Conclusion: MDR E.coli and K. pneumoniae were the most commonly observed bacterial colonizations in
      patients with spinal cord lesion who were admitted at our institute. E. coli isolates are highly resistant to almost all antimicrobials except aminoglycosides and carbapenems. K. pneumoniae isolates are highly resistant to all antimicrobials which were firstly found resistant to aminoglycosides and carbapenems in the 2015.
      PubDate: 2019-01-28
      Issue No: Vol. 63, No. 2 (2019)
       
  • Cognitive impairment and associated factors in the elderly at Pracha Niwet
           Village in Thailand

    • Authors: Chotiman Chinvararak, Natsara Dumrongpiwat, Puangsoi Worakul, Sookjaroen Tangwongchai
      Pages: 73 - 78
      Abstract: Background: Thailand has already become an aging society. Previous studies showed that cognitive impairment is one of the most common problems in the elderly. The prevalence of major neurocognitive disorder globally is between 5 - 7%. Currently, there are still limited data of cognitive impairment in Thailand. Objectives: To determine the prevalence of cognitive impairment and to explore factors associated with it. Methods: A descriptive study was conducted in the elderly aged above 60 years at Pracha Niwet Village from
      September to October 2017. The research instruments consisted of four questionnaires: 1) the demographic data form, 2) the mini – mental state examination: Thai version (MMSE – Thai 2002), 3) the Thai geriatric depression scale (TGDS), and 4) the Thai version of the Pittsburgh sleep quality index (T-PSQI). The prevalence of cognitive impairment was presented by frequency and percentage. The associated factors of cognitive impairment were analyzed by chi-square test, Fisher’s exact test, and Pearson’s correlation coefficient. The predictors of cognitive impairment were analyzed by logistic regression analysis. Results: Among 254 participants with the mean age of 77.1 7.3 years old; 66.5% of them were female. The
      prevalence of cognitive impairment was 7.5% and the mean of MMSE – Thai 2002 score was 25.8 3.6. The
      associated factors of cognitive impairment were hyperlipidemia ( < 0.01) and cardiovascular diseases ( < 0.05). Age, income, sleep duration, and TGDS score were correlated with MMSE – Thai 2002 score (r = -0.435, 0.271, -0.682, and -0.213, respectively). The predictors for cognitive impairment were hyperlipidemia and cardiovascular diseases ( < 0.05). Conclusion: The prevalence of cognitive impairment was 7.5%. The associated factors and predictors of
      cognitive impairment were hyperlipidemia and cardiovascular diseases.
      PubDate: 2019-01-28
      Issue No: Vol. 63, No. 2 (2019)
       
  • Impact of self-contact lens fitting with uncorrected refractive error on
           visual acuity and lens movement in contact lens wearers

    • Authors: Pussadee Paensuwan, Pavasut Leedasawat, Wanachat Chaiyasan, Darawan Pejchang
      Pages: 79 - 87
      Abstract: Background: Contact lenses are increasingly popular for refractive error correction. An eye examination and
      contact lens fitting for individual wearers are very important for best visual acuity and fitting accomplishment.
      Most Thai contact lens users buy their lenses from local shops and fitted the lens themselves without
      professional eye care services. This article reports on the impact of self-contact lens fitting on visual acuity and
      lens movement to establishes the requirement of contact lens access control. Objectives: To investigate the impact of self-contact lens fitting focusing on the uncorrected refractive error via visual acuity measurement and to determine the effect of lens base curve on lens movement in contact lens wearers. Methods: A total of sixty eyes of 30 contact lens wearers were recruited. The contact lens parameters were taken from the lenses’ package. Corneal curvature was determined using corneal topography. A best-corrected visual acuity and over-refraction were assessed by placing contact lens of the subjects with or without prescription using a phoropter and a distance chart for Early Treatment Diabetic Retinopathy Study (ETDRS). Lens movement was determined for a proper fitting via ocular micro-bioscope. Results: All subjects used contact lenses with 8.6 mm base curve and 14.2 mm diameter. All of them bought their lenses without a prescription. There was a significant difference between corrected spherical equivalent refraction and subject’s contact lens power ( < 0.001). The poor visual acuity with the subject’s lenses was significantly improved upon over-refraction ( < 0.001). Only half of eligible eyes qualified for an optimal lens movement with their recent contact lens. Conclusion: The self-contact lens fitting without eye examination might induce lens complications. There
      is a high prevalence of contact lens wearers who fitted their lenses depending on their own decision without an eye examination. There is 91.7% of subjects who required an over-refraction to achieve the best visual acuity. Only half of eligible eyes showed appropriate lens movement with the contact lens used. A regular contact lens assessment by eye practitioners should be done prior to and during using contact lens for improvement of best vision.
      PubDate: 2019-01-28
      Issue No: Vol. 63, No. 2 (2019)
       
  • In vitro biocompatibility of novel titanium-based amorphous alloy thin
           film in human osteoblast-like cells

    • Authors: Saran Tantavisut, Boonrat Lohwongwatana, Atchara Khamkongkaeo, Aree Tanavalee, Pairat Tangpornprasert, Pubul Ittiravivong
      Pages: 89 - 93
      Abstract: Background: Toxic free Ti-based amorphous alloy has the potential to be used in biomedical fields due to its
      excellent biocompatibility and osseointegration. Objectives: The purpose of this study was to develop a series of Ti44Zr10Pd10Cu6+ Co23-Ta7 ( = 0, 4, 8)
      and examine their biocompatibility, biological properties, and toxicity in osteoblast-like cells. Methods: Having developed the alloy ingots by induction melting, we used the cast rod as a plasma cathode in a filtered cathodic vacuum arc deposition chamber to coat a 25-nm thin film of amorphous alloy on cover glass slides. These coated cover glass slides were then examined for biocompatibility. The biocompatibility tests in SaOS2 osteoblast-like cells were performed using a methylthiazol tetrazolium assay and alizarin red staining. The medical grade Ti-6Al-4V alloys was studied in parallel as a control material. Results: There was no statistically significant difference in number of living cells between all novel alloys
      compared with Ti-6Al-4V thin film. Alizarin red staining showed that all novel alloy thin film had significantly
      higher percentage area of calcification in comparison with Ti-6Al-4V thin film control ( < 0.05). In term of calcification size, the Ti44Zr10Pd10Cu10Co19Ta7 and Ti44Zr10Pd10Cu14Co15Ta7 showed significantly greater calcification than control ( < 0.05) while Ti44Zr10Pd10Cu6Co23Ta7 also demonstrated larger calcification in comparison with control but no statistical significance ( = 0.27). Conclusion: The results indicated that all investigated Ti-based alloys were found to be non-cytotoxic and
      support differentiation of osteoblast-like cells.
      PubDate: 2019-01-28
      Issue No: Vol. 63, No. 2 (2019)
       
  • Mental health status and quality of life of the elderly in rural Saraburi

    • Authors: Thanan Supasiri, Somrat Lertmaharit, Thanapoom Rattananupong, Parinya Kitidumrongsuk, Vitool Lohsoonthorn
      Pages: 95 - 101
      Abstract: Background: Mental health problems are frequently underdiagnosed in older populations. Mental health
      problems and poor quality of life (QoL) can lead to adverse health outcomes and economical loss. Awareness
      of the problems can lead to finding their causes and proper managements. Objective: To evaluate the mental health status and QoL of the older population in a community in Saraburi
      Province, Thailand. Methods: Secondary data from a cross-sectional survey with simple random sampling to evaluate mental health status and QoL of the elderly were used. The survey was done by interviewing participants aged 55 years and above by 183 4th-year medical students of the Faculty of Medicine, Chulalongkorn University. The mental health status and QoL were assessed by the Depression Anxiety and Stress Scales (DASS-21) and the Older People’s Quality of Life (OPQOL-brief) questionnaires. Data were analyzed using descriptive and Kruskal Wallis test statistics. Results: Of the 238 participants who completed the questionnaires, 74 (31.1%) had at least one negative emotional state from stress, depression or anxiety. The average QoL score from the OPQOL-brief was 52.04 (SD 8.81) out of 65. The average global QoL was 3.63 (SD 0.91) out of 5. The QoL was significantly different among various levels of stress, depression or anxiety  < 0.001. Conclusion: The study revealed the prevalence of mental health problems which was as high as 31%. These
      mental problems could lead to major physical problems and economical loss; thus, the management such as
      holistic health care should be promoted. The overall QoL in this study population was in the mid- to high- range. The severity of mental problems of the subjects was negatively correlated to the QoL.
      PubDate: 2019-01-28
      Issue No: Vol. 63, No. 2 (2019)
       
  • Reliability and validity of the family state and functioning assessment
           scale

    • Authors: Suchat Supphapitiphon, Napakkawat Buathong, Siriluck Suppapitiporn
      Pages: 103 - 109
      Abstract: Background: Family significantly influences the health of family members in both positive and negative ways.
      There are limited instruments in Thailand for assessing family state and functioning on adult patients. Objectives: To examine the validity and reliability of the family state and functioning assessment scale (FSFAS)
      which was designed to assess the extent one perceived family issues and functioning. Methods: The scale was conducted on 1,200 Thai adults: 800 outpatients attending hospitals and 400
      participants in the community. Of the sample, 70% were women and the mean age was 50.4 years. The psychometric properties of the scale were examined in terms of construct validity and reliability. Exploratory factor analysis with principal components analysis and varimax rotation was performed to assess factor structures. Cronbach’s alpha coefficient was calculated to estimate reliability. Results: Exploratory factor analysis showed that the scale had a five-factor structure (support, discipline,
      communication and problem solving, emotional status and relationship) that accounted for 57.3% of the total
      variance. The final version of the scale consisted of 25 items with a Cronbach’s alpha coefficient of 0.87 for
      the total and 0.70 - 0.84 for the subscales. Conclusions: The scale has acceptable factorial validity and internal consistency reliability which can be a useful instrument for assessing family state and functioning.
      PubDate: 2019-01-28
      Issue No: Vol. 63, No. 2 (2019)
       
  • SCN5A gene exome sequencing profile in sudden unexplained nocturnal death
           syndrome in Thai population

    • Authors: Rachtipan Pitiwararom, Kornkiat Vongpaisarnsin, Udomsak Hoonwijit
      Pages: 111 - 118
      Abstract: Background: Sudden unexplained nocturnal death syndrome (SUNDS) or Lai-tai is a sudden death that often
      occurs in Southeast Asia. The characteristics of SUNDS cases are healthy young males, 20 – 49 yrs., that suddenly die during sleep with no relevant medical history. Previous studies found that SUNDS is similar to Brugada syndrome (BrS) which correlates to SCN5A mutations. Moreover, SCN5A variations affect sodium ion channel functions are different from one populations to anothers. Objective: The aim of this study is to describe the phenotype of SUNDS cases in the Thai population and establish SCN5A gene exome sequencing profiles using Next-Generation sequencing. Methods: All characteristics data of 12 SUNDS cases in the Thai population were collected. Microscopic
      examinations were analyzed. Postmortem genetic testing of SCN5A gene exome sequencing profiles in 12 SUNDS cases using Next-Generation Sequencing were performed. Pathogenicities were predicted using Polyphen-2 for missense variants and Mutationtaster for frameshift mutations. As for combined pathogenicity results, Combined Annotation Dependent Depletion (CADD) scores < 20 were filtered out. After that, SCN5A variants were compared with ExAC, 1000G, ClinVar and previous reports. Descriptive analysis in SUNDS cases characteristics were analyzed using Microsoft Excel 2013. Results: Characteristics of SUNDS cases with microscopic examination in the Thai population were shown. SCN5A gene exome sequencing profile in 12 SUNDS cases in the Thai population were generated. Two frameshift and six missense variants on the SCN5A gene from four SUNDS cases (33.34%) were found that potentially significantly affect sodium channel function. Only G599R has been previously reported. Other variants are novel (T92N, E171G, A178T, L1646fs, N1659S, E1804fs and E2013K). Conclusion: Phenotype and SCN5A gene exome sequencing profiles for SUNDS cases in the Thai population
      were shown. Our results could be useful for forensic pathologists and medical practitioners to keep these variants as a possible risk variants and closely observed in every SUNDS in the Thai population.
      PubDate: 2019-01-28
      Issue No: Vol. 63, No. 2 (2019)
       
  • Preparation and characterization of demineralized bone matrix/chitosan
           composite scaffolds for bone tissue engineering

    • Authors: Panudda Dechwongya, Korbtham Sathirakul, Baldur Kristjánsson, Suwabun Chirachanchai, Sittisak Honsawek
      Pages: 119 - 126
      Abstract: Background: A propitious alternative to supply bone substitutes is to develop living tissue substitutes based
      on biodegradable materials. Demineralized bone matrix (DBM) can support and promote osteogenesis; scaffold is also attractive for use in bone tissue engineering. Chitosan scaffold has been shown to possess biological and mechanical properties suitable for tissue engineering and clinical applications. Objectives: This study aimed to develop a novel DBM/chitosan composite scaffold and to investigate whether
      or not it has the ability to support the attachment and proliferation of human periosteal cells in vitro for bone
      tissue engineering. Methods: Chitosan and DBM/chitosan scaffolds (ratios 1:1 and 1:2) were fabricated with a low-cost, freeze-drying technique via thermally induced phase separation. The microstructure, mechanical performance, and biological activity of the scaffolds were studied. Scanning electron microscopy was employed to monitor the surface variation of chitosan and DBM/chitosan porous scaffolds. Results: Both scaffolds had porosities and pore sizes between 80 and 250 microns. The compressive modulus
      of DBM/chitosan composite scaffolds was significantly higher than chitosan scaffolds. Growth of cells on 1:1 and 1:2 DBM/chitosan scaffolds had similar patterns throughout the cell-culture period and was significantly higher than that on chitosan scaffold on culture-day 14. The DBM/chitosan scaffolds have been developed with adequate pore structure and mechanical properties to serve as a support for periosteal cell growth. Conclusion: DBM/chitosan composite scaffolds have mechanical properties and porosity sufficient to support
      ingrowth of new bone tissue. Cell attachment and proliferation findings indicate that DBM/chitosan composite scaffolds may be used as promising materials for bone tissue engineering application
      PubDate: 2019-01-28
      Issue No: Vol. 63, No. 2 (2019)
       
  • MRI of cranial nerve enhancement: King Chulalongkorn Memorial Hospital
           (KCMH) case series

    • Authors: Supak Chutiphaijit, Sasitorn Petcharunpaisan
      Pages: 127 - 134
      Abstract: Abnormal enhancement of cranial nerves (CNs) can be observed in a variety of disease. We present eight
      cases of cranial nerve (CN) enhancement, including inflammatory process, hematologic malignancy, perineural spreading of extracranial tumor, cerebrospinal fluid seeding of high grade primary brain tumor, demyelination and post radiation change. Based on our case series, the findings cover board differential diagnoses. The use of contrast enhanced 3-dimensional (3D) T1-weighted image (T1WI) magnetic resonance imaging (MRI) and reasonable MRI sequences can increase conspicuity of the finding. Furthermore, incorporating underlying disease, clinical duration, and associated intracranial / extracranial findings may help narrow the probable etiologies.
      PubDate: 2019-01-28
      Issue No: Vol. 63, No. 2 (2019)
       
 
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