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MEDICAL SCIENCES (2406 journals)            First | 1 2 3 4 5 6 7 8 | Last

Showing 201 - 400 of 3562 Journals sorted alphabetically
Asian Biomedicine     Open Access   (Followers: 2)
Asian Journal of Cell Biology     Open Access   (Followers: 6)
Asian Journal of Health     Open Access   (Followers: 3)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 5)
Asian Journal of Medical and Pharmaceutical Researches     Open Access   (Followers: 2)
Asian Journal of Medical Sciences     Open Access   (Followers: 2)
Asian Journal of Medicine and Health     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access   (Followers: 1)
Asian Journal of Scientific Research     Open Access   (Followers: 3)
Asian Journal of Transfusion Science     Open Access   (Followers: 1)
Asian Medicine     Hybrid Journal   (Followers: 5)
Asian Pacific Journal of Cancer Prevention     Open Access  
Asian Pacific Journal of Health Sciences     Open Access   (Followers: 10)
ASPIRATOR : Journal of Vector-borne Disease Studies     Open Access  
Astrocyte     Open Access  
Atención Familiar     Open Access  
Atención Primaria     Open Access   (Followers: 2)
Atención Primaria Práctica     Open Access   (Followers: 1)
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche     Open Access  
Audiology - Communication Research     Open Access   (Followers: 10)
AUP Advances     Open Access   (Followers: 7)
Auris Nasus Larynx     Full-text available via subscription  
Australasian Journal of Ultrasound in Medicine (AJUM)     Hybrid Journal   (Followers: 1)
Australian Coeliac     Full-text available via subscription   (Followers: 2)
Australian Family Physician     Full-text available via subscription   (Followers: 3)
Australian Journal of Medical Science     Full-text available via subscription   (Followers: 3)
Autopsy and Case Reports     Open Access  
Avicenna     Open Access   (Followers: 3)
Avicenna Journal of Clinical Medicine     Open Access  
Avicenna Journal of Medicine     Open Access   (Followers: 1)
Bangabandhu Sheikh Mujib Medical University Journal     Open Access   (Followers: 1)
Bangladesh Journal of Anatomy     Open Access   (Followers: 2)
Bangladesh Journal of Bioethics     Open Access  
Bangladesh Journal of Medical Biochemistry     Open Access   (Followers: 4)
Bangladesh Journal of Medical Education     Open Access   (Followers: 2)
Bangladesh Journal of Medical Microbiology     Open Access   (Followers: 4)
Bangladesh Journal of Medical Physics     Open Access   (Followers: 1)
Bangladesh Journal of Medical Science     Open Access  
Bangladesh Journal of Medicine     Open Access   (Followers: 1)
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Bangladesh Journal of Scientific Research     Open Access   (Followers: 1)
Bangladesh Medical Journal     Open Access  
Bangladesh Medical Journal Khulna     Open Access  
Basal Ganglia     Hybrid Journal  
Basic Sciences of Medicine     Open Access   (Followers: 1)
Batı Karadeniz Tıp Dergisi / Medical Journal of Western Black Sea     Open Access  
Baylor University Medical Center Proceedings     Hybrid Journal  
BBA Clinical     Open Access  
BC Medical Journal     Free  
Benha Medical Journal     Open Access  
Beni-Suef University Journal of Basic and Applied Sciences     Open Access   (Followers: 3)
Bijblijven     Hybrid Journal  
Bijzijn     Hybrid Journal   (Followers: 1)
Bijzijn XL     Hybrid Journal  
Bio-Algorithms and Med-Systems     Hybrid Journal   (Followers: 2)
BioDiscovery     Open Access   (Followers: 2)
Bioelectromagnetics     Hybrid Journal   (Followers: 2)
Bioelectronic Medicine     Open Access   (Followers: 1)
Bioengineering & Translational Medicine     Open Access  
Bioethics     Hybrid Journal   (Followers: 19)
Bioethics Research Notes     Full-text available via subscription   (Followers: 15)
Biologics in Therapy     Open Access  
Biology of Sex Differences     Open Access   (Followers: 2)
Biomarker Research     Open Access   (Followers: 3)
Biomarkers in Medicine     Hybrid Journal   (Followers: 2)
BioMed Research International     Open Access   (Followers: 5)
Biomédica     Open Access  
Biomedical & Life Sciences Collection     Full-text available via subscription   (Followers: 3)
Biomedical and Biotechnology Research Journal     Open Access   (Followers: 1)
Biomedical Engineering     Hybrid Journal   (Followers: 16)
Biomedical Engineering and Computational Biology     Open Access   (Followers: 13)
Biomedical Engineering Letters     Hybrid Journal   (Followers: 6)
Biomedical Engineering Research     Open Access   (Followers: 7)
Biomedical Informatics Insights     Open Access   (Followers: 9)
Biomedical Journal     Open Access   (Followers: 4)
Biomedical Materials     Hybrid Journal   (Followers: 7)
Biomedical Microdevices     Hybrid Journal   (Followers: 9)
Biomedical Optics Express     Open Access   (Followers: 6)
Biomedical Photonics     Open Access  
Biomedical Reports     Full-text available via subscription  
Biomedical Research Reports     Full-text available via subscription   (Followers: 2)
Biomedical Safety & Standards     Full-text available via subscription   (Followers: 9)
Biomedical Science and Engineering     Open Access   (Followers: 7)
BioMedicine     Open Access  
Biomedicine Hub     Open Access  
Biomedicines     Open Access   (Followers: 1)
Biomedika     Open Access  
Biomolecular and Health Science Journal     Open Access   (Followers: 1)
Biophysics Reports     Open Access  
BioPsychoSocial Medicine     Open Access   (Followers: 8)
Biosafety and Health     Open Access   (Followers: 2)
Biosalud     Open Access   (Followers: 1)
Biostatistics & Epidemiology     Hybrid Journal   (Followers: 2)
Birat Journal of Health Sciences     Open Access  
BIRDEM Medical Journal     Open Access   (Followers: 1)
Birth Defects Research     Hybrid Journal  
Birth Defects Research Part A : Clinical and Molecular Teratology     Hybrid Journal   (Followers: 3)
Birth Defects Research Part C : Embryo Today : Reviews     Hybrid Journal  
BJR|Open     Open Access   (Followers: 1)
BJS Open     Open Access   (Followers: 1)
Black Sea Journal of Health Science     Open Access  
BLDE University Journal of Health Sciences     Open Access  
Blickpunkt Medizin     Hybrid Journal  
BMC Biomedical Engineering     Open Access  
BMC Medical Ethics     Open Access   (Followers: 22)
BMC Medical Research Methodology     Open Access   (Followers: 9)
BMC Medicine     Open Access   (Followers: 14)
BMC Obesity     Open Access   (Followers: 7)
BMC Proceedings     Full-text available via subscription   (Followers: 2)
BMC Research Notes     Open Access   (Followers: 4)
BMC Sports Science, Medicine and Rehabilitation     Open Access   (Followers: 34)
BMH Medical Journal     Open Access   (Followers: 2)
BMI Journal : Bariátrica & Metabólica Iberoamericana     Open Access  
BMJ     Hybrid Journal   (Followers: 1886)
BMJ Case Reports     Hybrid Journal   (Followers: 28)
BMJ Evidence-Based Medicine     Hybrid Journal   (Followers: 4)
BMJ Global Health     Open Access   (Followers: 3)
BMJ Innovations     Hybrid Journal   (Followers: 6)
BMJ Leader     Hybrid Journal  
BMJ Open     Open Access   (Followers: 44)
BMJ Open Quality     Open Access   (Followers: 19)
BMJ Open Science     Open Access   (Followers: 1)
BMJ Sexual & Reproductive Health     Hybrid Journal   (Followers: 2)
BMJ Surgery, Interventions, & Health Technologies     Open Access  
Bodine Journal     Open Access  
Boletín del Consejo Académico de Ética en Medicina     Open Access  
Boletín del ECEMC     Open Access  
Boletin Médico de Postgrado     Open Access  
Boletín Médico del Hospital Infantil de México     Open Access  
Bone     Hybrid Journal   (Followers: 18)
Bone and Tissue Regeneration Insights     Open Access   (Followers: 2)
Bone Marrow Research     Open Access   (Followers: 2)
Bone Reports     Open Access  
Bosnian Journal of Basic Medical Sciences     Open Access  
Bozok Tıp Dergisi / Bozok Medical Journal     Open Access  
Brachytherapy     Full-text available via subscription   (Followers: 6)
Brain and Development     Full-text available via subscription   (Followers: 5)
Brain Communications     Open Access   (Followers: 2)
Brain Connectivity     Hybrid Journal   (Followers: 5)
Brain Impairment     Full-text available via subscription   (Followers: 2)
Brazilian Journal of Medical and Biological Research     Open Access  
Brazilian Journal of Medicine and Human Health     Open Access  
Brazilian Journal of Pain (BrJP)     Open Access  
Brazilian Journal of Physical Therapy     Open Access   (Followers: 2)
Breastfeeding Review     Full-text available via subscription   (Followers: 19)
British Journal of Biomedical Science     Full-text available via subscription   (Followers: 7)
British Journal of General Practice     Full-text available via subscription   (Followers: 39)
British Journal of Hospital Medicine     Full-text available via subscription   (Followers: 16)
British Medical Bulletin     Hybrid Journal   (Followers: 6)
Buddhachinaraj Medical Journal     Open Access  
Bulletin Amades     Open Access  
Bulletin de la Société de pathologie exotique     Hybrid Journal   (Followers: 1)
Bulletin of Legal Medicine     Open Access  
Bulletin of Medical Sciences     Open Access  
Bulletin of the History of Medicine     Full-text available via subscription   (Followers: 21)
Bulletin of the Menninger Clinic     Full-text available via subscription  
Bulletin of The Royal College of Surgeons of England     Free  
Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products     Open Access  
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz     Hybrid Journal   (Followers: 6)
Burapha Journal of Medicine     Open Access  
Burns     Hybrid Journal   (Followers: 10)
Cadernos de Naturologia e Terapias Complementares     Open Access   (Followers: 1)
Calcified Tissue International     Hybrid Journal   (Followers: 2)
Canadian Bulletin of Medical History     Hybrid Journal  
Canadian Family Physician     Partially Free   (Followers: 13)
Canadian Journal of Pain     Open Access   (Followers: 2)
Canadian Journal of Rural Medicine     Full-text available via subscription   (Followers: 1)
Canadian Medical Association Journal     Open Access   (Followers: 18)
Canadian Medical Education Journal     Open Access   (Followers: 10)
Canadian Prosthetics & Orthotics Journal     Open Access  
Cannabis and Cannabinoid Research     Hybrid Journal   (Followers: 1)
Cardiac Electrophysiology Clinics     Full-text available via subscription   (Followers: 1)
Care Management Journals     Hybrid Journal   (Followers: 5)
Case Reports     Open Access  
Case Reports in Acute Medicine     Open Access   (Followers: 2)
Case Reports in Clinical Medicine     Open Access   (Followers: 2)
Case Reports in Clinical Nutrition     Open Access   (Followers: 1)
Case Reports in Clinical Pathology     Open Access   (Followers: 1)
Case Reports in Medicine     Open Access   (Followers: 3)
Case Reports in Transplantation     Open Access  
Case Reports in Vascular Medicine     Open Access  
Case Reports in Women's Health     Open Access   (Followers: 4)
Case Study and Case Report     Open Access   (Followers: 5)
CASUS : Revista de Investigación y Casos en Salud     Open Access   (Followers: 1)
CBU International Conference Proceedings     Open Access   (Followers: 3)
Cell & Bioscience     Open Access   (Followers: 6)
Cell Adhesion & Migration     Open Access   (Followers: 9)
Cell and Molecular Response to Stress     Full-text available via subscription   (Followers: 2)
Cell and Tissue Transplantation and Therapy     Open Access   (Followers: 2)
Cell Cycle     Full-text available via subscription   (Followers: 6)
Cell Death and Differentiation     Hybrid Journal   (Followers: 8)
Cell Death Discovery     Open Access   (Followers: 1)
Cell Health and Cytoskeleton     Open Access   (Followers: 1)
Cell Medicine     Open Access   (Followers: 6)
Cell Research     Hybrid Journal   (Followers: 8)
Cell Transplantation     Open Access   (Followers: 4)
CEN Case Reports     Hybrid Journal  
Central African Journal of Medicine     Full-text available via subscription  
Cephalalgia Reports     Open Access   (Followers: 2)
Ceylon Journal of Medical Science     Open Access  

  First | 1 2 3 4 5 6 7 8 | Last

Similar Journals
Journal Cover
Biomedical and Biotechnology Research Journal
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2588-9834 - ISSN (Online) 2588-9842
Published by Medknow Publishers Homepage  [427 journals]
  • Probiotics: The marvelous factor and health benefits

    • Authors: S Vijayaram, S Kannan
      Pages: 1 - 8
      Abstract: S Vijayaram, S Kannan
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):1-8
      The aim of this study is well stated to address in recent advances on probiotics in the past 50 years. Probiotics are the living cell organisms. It is a presence in human and animal gut. The probiotic organisms are natural antibiotics in the human-animal gut. This reviews the main role mechanisms of action in probiotics such as probiotics are antibiotics, probiotics in antibacterial activity, probiotic action in fish gut bacteria, dietary supplements of probiotics, gastrointestinal microbiota of fishes, microbial community of the gastrointestinal tract of fish, bioactive compounds from probiotic bacteria, probiotic uses in cancer therapeutic applications, and applications of probiotics. The most common probiotics are used in many ways such as boosting the immune system, inhibition of pathogenic organism, prevention of cancer, reduction of inflammatory bowel disease, reducing cholesterol level, and synthesis of Vitamin A. Nowadays, food products are mainly involved in chemical preservatives. These preservative agents are causing the disease to affect the human health. The probiotic food products are used to the development of human-animal health.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):1-8
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_87_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Exploring potential of phage therapy for tuberculosis using model organism

    • Authors: Vijay Singh Gondil, Sanjay Chhibber
      Pages: 9 - 15
      Abstract: Vijay Singh Gondil, Sanjay Chhibber
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):9-15
      Antibiotics, one of the miracle discoveries of the 20th century after world war revolutionized the treatment and prophylaxis of infectious diseases. Antibiotics led to an increase in the quality of health-care system but with the emergence of antibiotic-resistant bacterial strains compromised their very potential. The WHO calls bacterial resistance as one of the major threats to global health, food security, and development today. Antibiotic resistance poses a need of alternative therapy to conventional antibiotics. As proved in preantibiotic era phage therapy is effective against a number of successful pathogens and can be used as an alternative strategy to restrain stern infections such as antibiotic resistance tuberculosis (TB). In the present paper, effectiveness of phage therapy and use of model organisms for developing treatment strategy for antibiotic-resistant TB is discussed so as to explore new possibilities in battle against antibiotic resistance.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):9-15
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_93_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Anti-tuberculosis therapy: Urgency for new drugs and integrative approach

    • Authors: Lingaraja Jena, Bhaskar C Harinath
      Pages: 16 - 19
      Abstract: Lingaraja Jena, Bhaskar C Harinath
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):16-19
      Tuberculosis (TB) remains the major health problem causing morbidity and mortality throughout the world. Increase in multidrug resistant, extensively drug-resistant, and totally drug-resistant cases of tuberculosis are causing concern to the health administrators of TB control programs. In spite of tremendous research on drug targets and drugs in TB, no new drug which is safer and more effective, has come out. This mini-review focuses on different important drug targets in Mycobacterium tuberculosis reported and emphasizes the urgency for new drug development and integrative approach for successful control of TB.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):16-19
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_108_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Advances in protein tertiary structure prediction

    • Authors: Tayebeh Farhadi
      Pages: 20 - 25
      Abstract: Tayebeh Farhadi
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):20-25
      Proteins are composed of linear chains of amino acids that form a unique three-dimensional structure in their native environment. Such native structure favors the proteins to perform their biochemical activity. Protein is formed of some levels of structure. The primary structure of a protein is specified by the particular amino acid sequence. In an amino acid sequence, patterns of local bonding can be identified as secondary structure. The final level that forms a tertiary protein structure is composed of the mentioned elements and form after the protein folds into its native state. To find the native structure of proteins, the physicochemical principles as well as identifying the lowest free-energy states are considered as the best properties and to predict target proteins with unknown structures, the bioinformatics-based methods have earned considerable success. Protein structure prediction methods have been mainly classified into three types: ab Initio folding, comparative (homology) modeling and threading. Each mentioned method may be applied for a protein structure, depending on the existence of related experimental structures that are deposited in the PDB. Once an initial model is generated, refinement simulations are conducted to reassemble the global topology and the local structures of the protein chains. Since significant features of a model may be in regions that are structurally distinct from the template, refining of a primary model is influential. A trustful strategy is included a stereo-chemical check and discovering how the model deviates from the basic disciplines of known experimental structures.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):20-25
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_94_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Construction and genetic improvement of copper bioreporter Escherichia
           Coli

    • Authors: Kimia Taghavi, Puria Motamed Fath, Saman Hosseinkhani, Mohammad Mirzaei, Hadi Behrooj, Arda Kiani, Atefeh Abedini, Fatemeh Razavi
      Pages: 26 - 30
      Abstract: Kimia Taghavi, Puria Motamed Fath, Saman Hosseinkhani, Mohammad Mirzaei, Hadi Behrooj, Arda Kiani, Atefeh Abedini, Fatemeh Razavi
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):26-30
      Background: Copper is a pollutant compound which can cause earnest toxicity in human and some organisms. Bioreporters are frugal and non-toxic detectors for pollution compounds. Precedent designed recombinant Escherichia coli copper bioreporters with the lux gene of Vibrio fischeri or Aequorin luciferase of Jellyfish does not provide a high sensitivity. The aim of current study was to design an incipient Copper bioreporter with applying firefly luciferase and Copper resistance promoter of P. syringae pv.Tomato in Escherichia coli XL1-Blue. Methods: Recombinant pGL3 was obtained by applying the pGL3-Control vector to Escherichia coli XL1-Blue, by Polymerase Chain Reaction method and double digestion. Recombinant Escherichia coli cells were cultured with applying different concentrations of copper sulphate to study the activity of luciferase by Luminometer. Copper bioreporter specificity was resolute by different concentrations of Zinc sulfate and Ferric sulfate. Results: Recombinant Escherichia coli BL21, with copper promoter gene in pGL3 Vector showed the highest Luciferase activity in 0.1 millimolar of Copper sulfate. The highest Luciferase activity was in 0.09 millimolar and 1.0 millimolar of Zinc sulfate and Ferric sulfate respectively. Conclusion: Current study provided a categorical bioreporter for detecting copper, utilizing firefly luciferase with a high specificity (96.1%). By optimizing inhibitor factors, application of current copper bioreporter can be developed in human life.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):26-30
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_65_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Identification and development of oxoquinazoline derivatives as novel
           mycobacterial inhibitors targeting cell wall synthesis enzyme

    • Authors: Prasanthi Malapati, Krishna Siva Vagolu, Dhramarajan Sriram
      Pages: 31 - 38
      Abstract: Prasanthi Malapati, Krishna Siva Vagolu, Dhramarajan Sriram
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):31-38
      Background: Tuberculosis (TB) still remains the leading cause of death worldwide and was unanswered till date. Available treatment strategies have many drawbacks such as longer treatment period, side effects, and drug interactions, which result in patient noncompliance. In the present work, we thrived to develop inhibitors against unexplored key target glutamate racemase. Methods: Lead was identified from in-house database using differential scanning fluorimetry, inhibitors were developed by lead derivatization technique and evaluated them by various biological assays. Results: In oxoquinazoline series, compounds 18 (10.1 ± 0.62 μM) and 22 (5.23 ± 0.34 μM) were found to be the most promising potent inhibitors among all. These compounds also showed their inhibition on replicating and nonreplicating bacteria. Conclusion: Our attempt to develop the potent novel inhibitors against Mycobacterium tuberculosis resulted in developing few promising inhibitors, yet these compounds need further studies to answer all questions in drug discovery. Further optimization of compounds can result in still better compounds for treating TB.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):31-38
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_101_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Outdoor air pollution affects tuberculosis development based on
           geographical information system modeling

    • Authors: Esmaeil Rajaei, Maryam Hadadi, Majid Madadi, Jafar Aghajani, Mohanad Mohsin Ahmad, Poopak Farnia, Jalaledin Ghanavi, Parissa Farnia, Ali Akbar Velayati
      Pages: 39 - 45
      Abstract: Esmaeil Rajaei, Maryam Hadadi, Majid Madadi, Jafar Aghajani, Mohanad Mohsin Ahmad, Poopak Farnia, Jalaledin Ghanavi, Parissa Farnia, Ali Akbar Velayati
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):39-45
      Background : Daily intake of air is 30 Ib as compared with 2-Ib of food and 4½ of water. Thereby, breathing-contaminated air is as harmful as drinking or eating contaminated water or food, respectively. Recent research has highlighted the extent of outdoor air pollution in large cities and warranted high-quality studies to clarify the magnitude of the problem. Here, we evaluated the possible association between tuberculosis (TB) development and exposure to outdoor air pollution in a metropolitan city of Tehran. Methods: Extraction and analysis of relevant data. Investigation performed on TB patients (n = 1167) that were residing in Tehran for the past 10 years. The average concentration of sulfur dioxide (SO2), nitrogen dioxide, carbon monoxide (CO), and particles with an aerodynamic diameter of ≤ 2.5μm (PM2.5) and ≤ 10.0 (PM10) was measured from Tehran Air Quality Control Corporation (TAQCC). Patient and ecological informations were analyzed using geographical information system. Results: Based on TAQCC, Tehran had an average of 180–250 polluted days per year for the last 10 years. The high incidence of pulmonary TB (18 to 31/100,000) was detected in populations which were exposed to high concentration of CO (2.7 to 5.2 parts per million, 95% confidence interval [CI]; 1.10 to 1.90) and PM2.5(35 to 42μg/m3; 95% CI 1.03 to 1.80). The level of SO2,NO, and PM10was also high but not significantly related to TB (P > 0.05). Conclusion: The long-term exposure to PM2.5 and CO was positively associated with TB development.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):39-45
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_5_18
      Issue No: Vol. 2, No. 1 (2018)
       
  • Comparative study of LoopampTM Mycobacterium tuberculosis Complex Kit for
           Rapid Detection of Mycobacterium tuberculosis complex in cameroon

    • Authors: Valerie Flore Donkeng Donfack, Laure Ngando, Eric Walter Yone Pefura, Dieudonné Shubesi Che, Ghislaine Ateba, Jean Joel Rim Bigna, Jean Louis Abena Foe, Christopher Kuaban, Sara Eyangoh
      Pages: 46 - 52
      Abstract: Valerie Flore Donkeng Donfack, Laure Ngando, Eric Walter Yone Pefura, Dieudonné Shubesi Che, Ghislaine Ateba, Jean Joel Rim Bigna, Jean Louis Abena Foe, Christopher Kuaban, Sara Eyangoh
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):46-52
      Background: The most practical test for identifying tuberculosis (TB) in developing countries remains smear microscopy. However, due to its low sensitivity, a new point-of-care diagnostic method has been developed. The purpose of this study was to assess the performance of TB-Loop-mediated isothermal amplification (TB-LAMP) test on sputum samples of suspected TB cases. Methods: Suspected pulmonary TB patients (527) from Jamot Hospital and without any history of anti-TB treatment were consecutively included in the study. Smear microscopy, TB-LAMP, GeneXpert® MTB/RIF, and liquid culture using BACTEC 960 Mycobacteria Growth Indicator Tube (MGIT) were performed on sputum samples collected from these patients. The sensitivity and specificity of TB-LAMP were compared with smear microscopy and GeneXpert® MTB/RIF. MGIT culture was the gold standard. Results: TB-LAMP and smear microscopy showed sensitivities of 82.6% (95% confidence interval [CI], 76.9–87.2) and 53.6% (95% CI, 46.8–60.3), respectively, and specificities of 96.0% (95% CI, 93.2–97.7) and 99.0% (95% CI, 97.1–99.7), respectively. The sensitivity and specificity of TB-LAMP were similar to GeneXpert®, (89.9%; 95% CI, 85.0–93.3 and 97.0%; 95% CI, 94.4–98.4). Conclusion: TB-LAMP is more sensitive than currently used microscopy. It presents a favorable diagnostic tool for TB in peripheral laboratories with limited equipment, such as those in developing countries.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):46-52
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_86_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Studies on 3H-levamisole binding to murine splenic lymphocytes, normal,
           malignant human lymphocytes and fate of levamisole in cell culture

    • Authors: B Nageshwari, Ramchander Merugu
      Pages: 53 - 58
      Abstract: B Nageshwari, Ramchander Merugu
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):53-58
      Background: Levamisole at high concentrations has been shown to have anticancer and immunosuppressive actions. Methods: In the present study, fate of levamisole in cell culture and 3 H-levamisole binding to murine splenic lymphocytes, normal and malignant human lymphocytes has been investigated. Results: High-performance liquid chromatography analysis of cell culture supernatants of myeloma cells treated with levamisole has shown that products of levamisole appeared with progressive culture period indicating a metabolic transformation. 3 H-levamisole binding assays indicate that the binding was signifi cantly higher in lysates of lipopolysaccharide-stimulated murine splenic lymphocytes as compared to whole cells. Conclusion: The degradation of levamisole could be one more possible reason for the high concentration of levamisole required to get the desirable cytotoxic effect on myeloma cells.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):53-58
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_106_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Cytotoxicity effects of endodontic irrigants on permanent and primary cell
           lines

    • Authors: Manikandan Ravinanthanan, Mithra N Hegde, Veena Shetty, Suchetha Kumari
      Pages: 59 - 62
      Abstract: Manikandan Ravinanthanan, Mithra N Hegde, Veena Shetty, Suchetha Kumari
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):59-62
      Background: Irrigants plays a vital role in disinfection of the root canal system. Although concentration dependent, a fine balance between antimicrobial efficacy and biocompatibility need to be maintained at all times. The aim of the present study was to evaluate the cytotoxicity of conventional irrigants on two different cell lines in a dose-dependent manner in vitro. Methods: Sodium hypochlorite (NaOCl), chlorhexidine digluconate (CHX), and iodine potassium iodide (IKI) were prepared in concentrations of 5%, 2.5%, 2%, and 1%. About 0.9% saline served as negative control and Biopure MTADTM (100%) as positive control. Permanent (Henrietta Lacks [HeLa]) and primary (human gingival fibroblast [HGF]) cell lines were chosen to evaluate the cytotoxicity of the irrigants by trypan blue assay. A volume of 30 μl of the cell suspension was treated with 20 μl of irrigants. The cell suspension was loaded into Neubauer chamber after 5 min, and cell count was performed under inverted microscope and expressed as viability percentage. Results: NaOCl at all concentrations was cytotoxic on both cell lines; MTAD on HeLa had nonviable scores with limited viability on HGF. Only 1% IKI had better viability than higher concentrations. Although 1% CHX had higher viability on both cell lines, bactericidal concentration of 2% CHX showed promising results. Conclusion: Target cell line (HGF) appears to be more sensitive than the use of nontarget cell line (HeLa) for evaluating cytotoxicity. NaOCl and MTAD were cytotoxic and should be used with caution. Lower concentrations of CHX appear to be less cytotoxic than any irrigant and concentrations tested.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):59-62
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_92_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • A comparison of three diagnostic platforms for the detection of influenza
           A and B in children

    • Authors: Furqan Kabir, Marvi Tariq, Fatima Aziz, Syed Imran Rizvi, Shahida Qureshi, Asad Ali, Najeeha Talat Iqbal
      Pages: 63 - 67
      Abstract: Furqan Kabir, Marvi Tariq, Fatima Aziz, Syed Imran Rizvi, Shahida Qureshi, Asad Ali, Najeeha Talat Iqbal
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):63-67
      Background: Viral flu is the predominant cause of hospitalization in young children, which invariably leads to enhanced morbidity and mortality in children in developing countries. Initial treatment of viral flu is based on presumptive diagnosis. Bedside testing is not common in clinical settings because of variable sensitivity and specificity of rapid tests in different settings. Methods: To address this issue, we evaluated the performance of Binax influenza A/B rapid testing kit against two robust molecular platforms (quantitative real-time polymerase chain reaction [qRT-PCR] and TaqMan array card [TAC]) in 24 nasopharyngeal (NP) swabs, collected from children under 5 years of age. Results: Binax was found to be less sensitive (56%), but 100% specific compared to qRT-PCR (100%) and TAC (>100%). Using TAC cards, 75% of samples were found to be coinfected with other bacterial and viral targets. Conclusion: Binax flu is suitable for bedside testing in clinical and community settings. The negative results of Binax should be interpreted with caution and confirmed by rapid molecular tests.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):63-67
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_107_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Preparation of chitosan-coated Fe3O4 nanoparticles and assessment of their
           effects on enzymatic antioxidant system as well as high-density
           lipoprotein/low-density lipoprotein lipoproteins on wistar rat

    • Authors: Bahare Khedri, Kahin Shahanipour, Soheil Fatahian, Fariba Jafary
      Pages: 68 - 73
      Abstract: Bahare Khedri, Kahin Shahanipour, Soheil Fatahian, Fariba Jafary
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):68-73
      Background: Recently, the nanoparticle (NP) application in many fields of medicine due to their specific physical and chemical properties has been developed. Therefore, especially in vivo evaluation of their toxicity is necessary. The aim of this study was to compare the toxicity of Fe3O4NPs coated with biocompatible compounds and uncoated NPs. Methods: Wetted chemical method (or wet chemical method) was used to synthesize Fe3O4NPs. The synthesized NPs were coated with chitosan and the coating interactions were investigated by Fourier-transform infrared spectroscopy. The magnetic and structural properties of Fe3O4and coated Fe3O4NPs were evaluated by transmission electron microscope and X-ray diffraction. The toxicity assessment of Fe3O4and coated Fe3O4NPs was studied in mice by intraperitoneal injections during the 1-month period. Antioxidant enzyme glutathione peroxidase (GPX), malondialdehyde, and low-density lipoprotein/high-density lipoprotein were measured 15 and 30 days after injection. Results: The synthesized NPs have a single phase and spinal structure and their size distribution in the net form is 5–10 nm. Some factors were changed due to the injection of both uncoated and coated NPs. The all-used concentration of chitosan-coated Fe3O4NPs could increase the GPX enzyme activity. The Fe3O4NPs can reduce the GPX enzyme activity in high concentration (50 mg/kg, 100 mg/kg, and 150 mg/kg). Conclusion: The results indicated that NPs based on their dosage and body condition can induce toxicity effects in the body. It should be mentioned that the chitosan-coated ones can decrease their effects.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):68-73
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_98_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Genetic polymorphism of rare mutations in Mycobacterium
           tuberculosis-infected patients in Delhi

    • Authors: Himanshu Vashistha, Mahmud Hanif, Kamal Kishore Chopra, Divya Shrivastava, Ashwani Khanna
      Pages: 74 - 81
      Abstract: Himanshu Vashistha, Mahmud Hanif, Kamal Kishore Chopra, Divya Shrivastava, Ashwani Khanna
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):74-81
      Background: There is a wide variation in existing Mycobacterium tuberculosis strains across the globe, and false results in line probe assay (LPA) can occur due to the presence of unique genetic mutations in different settings. Objectives: An attempt was made to observe uncommon mutations in multidrug-resistant tuberculosis (MDR-TB) strains and determination of genetic diversity by spoligotyping and to study the treatment outcome in patients with uncommon mutations. Materials and Methods: Band pattern analysis of LPA strips was performed as per manufacturer's instructions. DNA sequencing was performed to confirm the presence of uncommon mutations in Intermediate Reference Laboratory in Delhi state. Results: Four uncommon mutations were recognized along with 12 unique spoligotype patterns which serve as an update to worldwide databases. The noteworthy presence of a spoligotype previously rarely seen in India was the SIT53/T1 pattern. Central Asian (CAS) spoligotype was highly associated with MDR followed by Beijing type. During follow-up, the treatment outcomes of cases showing uncommon mutations were considered as cured, after completion of their treatment. Conclusion: The rifampicin resistance appears to be an effective marker of MDR-TB. The presence of uncommon mutations confirms genetic polymorphism that may require treatment targeted at both drug-resistant and drug-susceptible phenotypes for the better management of patients with MDR-TB.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):74-81
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_13_18
      Issue No: Vol. 2, No. 1 (2018)
       
  • Pacemaker site infection caused by Rapidly Growing Nontuberculous
           Mycobacteria (RGM)

    • Authors: Jhansi Vani Devana, Narasimhan Calambur, B Ravinder Reddy
      Pages: 82 - 84
      Abstract: Jhansi Vani Devana, Narasimhan Calambur, B Ravinder Reddy
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):82-84
      There has been an increased use of cardiac pacemaker device utilization in cardiac patients with a corresponding increase of device-related infections in these patients. The common cause of postpacemaker implantation infection is either Gram-positive or Gram-negative bacteria. Infection of pacemaker implantation site due to nontuberculous mycobacteria is rare. Globally, thirty-two cases of pacemaker device infections caused by nontuberculous mycobacteria were reported. It is important to carry out not only species identification of mycobacteria but also drug susceptibility testing to start precise treatment to those patients, who are infected with atypical mycobacteria. We report a patient with pacemaker pocket infection due to Mycobacterium chelonae.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):82-84
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_6_18
      Issue No: Vol. 2, No. 1 (2018)
       
  • Commentary on “Maes R. Tuberculosis serology is useful in rural
           areas: BBRJ 2017;1(2):85-93”

    • Authors: Bhaskar C Harinath, Lingaraja Jena
      Pages: 85 - 86
      Abstract: Bhaskar C Harinath, Lingaraja Jena
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):85-86

      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):85-86
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_100_17
      Issue No: Vol. 2, No. 1 (2018)
       
 
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