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AJSP: Reviews & Reports
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Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1082-9784 - ISSN (Online) 1533-4015
Published by Wolters Kluwer Health

[1 journal]

Glandular Lesions of the Uterine Cervix: Cytology and Histology Updates
- Authors: Duggan; Máire A.
  Abstract: No abstract available
  PubDate: Thu, 01 Mar 2018 00:00:00 GMT-
Adenocarcinoma of the Uterine Cervix: Measuring, Staging, and Synoptic
Reporting
- Authors: McCluggage; W. Glenn
  Abstract: Adenocarcinoma of the cervix is increasing in incidence in relative and real terms given the reduction in cervical squamous carcinomas in many developed countries. In this review, various aspects relating to the pathological staging of cervical carcinomas are discussed with emphasis on adenocarcinomas. These include the distinction between adenocarcinoma in situ and invasive lesions and the measurement of invasive adenocarcinomas; both of these issues are often more difficult than with the corresponding squamous lesions. The measurement of multifocal cervical carcinomas is covered with discussion of the International Collaboration on Cancer Reporting recommendations, although these were chiefly proposed for multifocal squamous carcinomas. The issue of adnexal involvement in cervical adenocarcinoma is discussed. A checklist of parameters that should be included on the pathology report of resection specimens of cervical carcinomas is presented, again with particular reference to the International Collaboration on Cancer Reporting recommendations. The advantages of synoptic reporting, in comparison to free text reporting, are discussed.
  PubDate: Thu, 01 Mar 2018 00:00:00 GMT-
Primary Adenocarcinoma of the Uterine Cervix: Classification and Grading
- Authors: Pirog; Edyta Catalina
  Abstract: Cervical adenocarcinomas are a group of malignancies with several distinct histologic tumor types, which include endocervical usual type, endometrioid, intestinal, villoglandular, gastric, signet ring, serous, clear cell, and mesonephric. Diagnosis of cervical adenocarcinoma, in particular early diagnosis, and classification of the tumor type may pose a significant challenge. The goal of this article is to review the current classification, diagnostic criteria, adjunct markers, and differential diagnosis of various subtypes of cervical adenocarcinomas. The article presents up-to-date summary of such problematic issues as differentiating glandular tumors from benign mimics, differentiating early invasive lesions from adenocarcinoma in situ, determining the tumor type, and, finally, differentiating primary cervical adenocarcinoma from uterine endometrioid adenocarcinoma. Discussion of human papillomavirus detection in different tumor types is provided.
  PubDate: Thu, 01 Mar 2018 00:00:00 GMT-
Glandular Pseudoneoplasms of the Uterine Cervix
- Authors: Harrison; Beth T.; Nucci, Marisa R.
  Abstract: Several benign glandular lesions of the uterine cervix can mimic malignancy. These glandular pseudoneoplasms include microglandular hyperplasia, lobular and diffuse laminar types of endocervical glandular hyperplasia, tunnel clusters, adenomyoma of endocervical type, mesonephric hyperplasia, ectopic prostate, endometriosis and tuboendometrioid metaplasia, and the Arias-Stella reaction, among others. Each of these entities may show a variety of unusual morphologic features that complicate the diagnosis. This review covers the clinical and pathologic features of this selected group of glandular pseudoneoplasms, as well as the immunohistochemical and molecular markers that distinguish them from premalignant and malignant lesions in the differential diagnosis. New developments in the molecular characterization of the latter are briefly discussed in regard to their potential utility in the diagnosis of selected challenging cases. For example, recurrent KRAS mutations distinguish microglandular-like endometrial adenocarcinoma from microglandular hyperplasia, as well as mesonephric and mesonephric-like carcinomas from mesonephric hyperplasia; a p53 mutant phenotype favors minimal deviation or gastric-type adenocarcinoma over lobular endocervical glandular hyperplasia (typical), tunnel clusters, endocervical adenomyomas, and other lesions, and p16 positivity has emerged as a very useful marker of human papillomavirus–related neoplasia in the appropriate clinicopathologic setting.
  PubDate: Thu, 01 Mar 2018 00:00:00 GMT-
Case Review: Gastric-Type Adenocarcinoma of the Uterine Cervix and
Precursor Lesions
- Authors: Park; Kay J.
  Abstract: A case of gastric-type endocervical adenocarcinoma that was originally diagnosed as possibly of endometrial or pancreatobiliary/upper gastrointestinal tract origin is reported. This report reviews the pertinent medical literature, differential diagnoses, etiology, and pitfalls of this disease, as well as use of immunohistochemistry and human papillomavirus (HPV) testing in establishing the diagnosis. The morphology of these tumors can range from extremely well differentiated (minimal deviation adenocarcinoma) to poorly differentiated, and therefore, the differential diagnosis can be quite varied. On one end of the spectrum, the tumor can be difficult to differentiate from benign endocervical glands, whereas at the other end, it can be difficult to determine the origin of the tumor. Because these tumors are not associated with HPV infection, the use of ancillary studies such as p16 can be misleading, and these may not be detected on standard Papanicolaou cytology with HPV screening. Molecular testing was also performed in this case with a TP53 hotpot mutation detected, along with mutations in ELF3 and PTPRS.
  PubDate: Thu, 01 Mar 2018 00:00:00 GMT-
Metastatic Adenocarcinoma to the Uterine Cervix Versus Primary Cervical
Adenocarcinoma
- Authors: Djordjevic; Bojana; Busca, Aurelia; Parra-Herran, Carlos
  Abstract: Adenocarcinoma metastases to the cervix can originate from the endometrium, the upper müllerian tract, or from extramüllerian sites such as the gastrointestinal and pancreatobiliary tract, bladder, breast, lung, or even the salivary gland. In some cases, the metastatic lesions have signet-ring morphology, infiltrative pattern, and/or extensive lymphovascular spread. In others, however, the distinction between a primary cervical lesion and a metastasis to the cervix is more challenging because metastases may mimic endocervical adenocarcinoma in situ by colonizing the native endocervical mucosa through intraepithelial spread. Careful morphologic interpretation, combined with immunohistochemistry, human papillomavirus molecular testing, and clinical correlation, is required in order to arrive at the correct diagnosis.
  PubDate: Thu, 01 Mar 2018 00:00:00 GMT-
The “Atypical Glandular Cells” Papanicolaou Test: Recent
Updates
- Authors: Li; Zaibo; Zhao, Chengquan
  Abstract: Atypical glandular cells are gynecologic cytology abnormalities representing glandular cells with morphologic changes that exceed obvious reactive/reparative changes, but fall short of an interpretation of adenocarcinoma either quantitatively or qualitatively. This cytological diagnosis occurs in less than 1% of the results of gynecologic cytology tests (0.2%–0.8%) but potentially reflects a wide range of conditions, from benign changes and cervical squamous/glandular precursor lesions, to invasive cervical or other gynecologic cancers. In this article, we aim at reviewing different subcategories, potential ancillary studies, histological follow-up results, and clinical management of atypical glandular cells.
  PubDate: Thu, 01 Mar 2018 00:00:00 GMT-