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  Subjects -> MEDICAL SCIENCES (Total: 7854 journals)
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MEDICAL SCIENCES (2040 journals)                  1 2 3 4 5 6 7 8 | Last

Showing 1 - 200 of 3562 Journals sorted alphabetically
16 de Abril     Open Access  
3D Printing in Medicine     Open Access   (Followers: 1)
AADE in Practice     Hybrid Journal   (Followers: 5)
ABCS Health Sciences     Open Access   (Followers: 3)
Abia State University Medical Students' Association Journal     Full-text available via subscription  
ACIMED     Open Access   (Followers: 1)
ACS Medicinal Chemistry Letters     Hybrid Journal   (Followers: 42)
Acta Bio Medica     Full-text available via subscription   (Followers: 2)
Acta Bioethica     Open Access  
Acta Bioquimica Clinica Latinoamericana     Open Access   (Followers: 1)
Acta Facultatis Medicae Naissensis     Open Access  
Acta Informatica Medica     Open Access   (Followers: 1)
Acta Medica (Hradec Králové)     Open Access  
Acta Medica Bulgarica     Open Access  
Acta Medica Colombiana     Open Access   (Followers: 1)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Medica Indonesiana     Open Access  
Acta Medica International     Open Access  
Acta medica Lituanica     Open Access  
Acta Medica Marisiensis     Open Access  
Acta Medica Martiniana     Open Access  
Acta Medica Nagasakiensia     Open Access  
Acta Medica Peruana     Open Access   (Followers: 2)
Acta Médica Portuguesa     Open Access  
Acta Medica Saliniana     Open Access  
Acta Scientiarum. Health Sciences     Open Access   (Followers: 1)
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 4)
Acupuncture and Natural Medicine     Open Access  
Addiction Science & Clinical Practice     Open Access   (Followers: 8)
Addictive Behaviors Reports     Open Access   (Followers: 8)
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / Health Sciences Journal of Adıyaman University     Open Access  
Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi     Open Access  
Advanced Biomedical Research     Open Access  
Advanced Health Care Technologies     Open Access   (Followers: 4)
Advanced Science, Engineering and Medicine     Partially Free   (Followers: 7)
Advances in Bioscience and Clinical Medicine     Open Access   (Followers: 5)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 29)
Advances in Life Course Research     Hybrid Journal   (Followers: 8)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Medical Education and Practice     Open Access   (Followers: 26)
Advances in Medical Ethics     Open Access  
Advances in Medical Research     Open Access  
Advances in Medical Sciences     Hybrid Journal   (Followers: 6)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Medicine     Open Access   (Followers: 3)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4)
Advances in Molecular Oncology     Open Access   (Followers: 2)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7)
Advances in Parkinson's Disease     Open Access  
Advances in Phytomedicine     Full-text available via subscription  
Advances in Preventive Medicine     Open Access   (Followers: 6)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20)
Advances in Regenerative Medicine     Open Access   (Followers: 3)
Advances in Skeletal Muscle Function Assessment     Open Access  
Advances in Therapy     Hybrid Journal   (Followers: 5)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5)
Advances in Wound Care     Hybrid Journal   (Followers: 11)
Aerospace Medicine and Human Performance     Full-text available via subscription   (Followers: 11)
African Health Sciences     Open Access   (Followers: 3)
African Journal of Biomedical Research     Open Access   (Followers: 1)
African Journal of Clinical and Experimental Microbiology     Open Access   (Followers: 2)
African Journal of Laboratory Medicine     Open Access   (Followers: 2)
African Journal of Medical and Health Sciences     Open Access   (Followers: 2)
African Journal of Trauma     Open Access   (Followers: 1)
Afrimedic Journal     Open Access   (Followers: 2)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 8)
AJOB Primary Research     Partially Free   (Followers: 3)
AJSP: Reviews & Reports     Hybrid Journal  
Aktuelle Ernährungsmedizin     Hybrid Journal   (Followers: 4)
Al-Azhar Assiut Medical Journal     Open Access  
Alexandria Journal of Medicine     Open Access   (Followers: 1)
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 2)
Alpha Omegan     Full-text available via subscription  
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 3)
Althea Medical Journal     Open Access  
American Journal of Biomedical Engineering     Open Access   (Followers: 13)
American Journal of Biomedical Research     Open Access   (Followers: 2)
American Journal of Biomedicine     Full-text available via subscription   (Followers: 7)
American Journal of Chinese Medicine, The     Hybrid Journal   (Followers: 4)
American Journal of Clinical Medicine Research     Open Access   (Followers: 7)
American Journal of Family Therapy     Hybrid Journal   (Followers: 11)
American Journal of Law & Medicine     Full-text available via subscription   (Followers: 11)
American Journal of Lifestyle Medicine     Hybrid Journal   (Followers: 5)
American Journal of Managed Care     Full-text available via subscription   (Followers: 11)
American Journal of Medical Case Reports     Open Access   (Followers: 1)
American Journal of Medical Sciences and Medicine     Open Access   (Followers: 4)
American Journal of Medicine     Hybrid Journal   (Followers: 47)
American Journal of Medicine and Medical Sciences     Open Access   (Followers: 1)
American Journal of Medicine Studies     Open Access   (Followers: 1)
American Journal of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American Journal of the Medical Sciences     Hybrid Journal   (Followers: 12)
American Journal on Addictions     Hybrid Journal   (Followers: 9)
American medical news     Free   (Followers: 3)
American Medical Writers Association Journal     Full-text available via subscription   (Followers: 5)
Amyloid: The Journal of Protein Folding Disorders     Hybrid Journal   (Followers: 5)
Anales de la Facultad de Medicina     Open Access  
Anales de la Facultad de Medicina, Universidad de la República, Uruguay     Open Access  
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1)
Analgesia & Resuscitation : Current Research     Hybrid Journal   (Followers: 5)
Anatolian Clinic the Journal of Medical Sciences     Open Access  
Anatomica Medical Journal     Open Access  
Anatomical Science International     Hybrid Journal   (Followers: 3)
Anatomical Sciences Education     Hybrid Journal   (Followers: 1)
Anatomy     Open Access   (Followers: 1)
Anatomy Research International     Open Access   (Followers: 2)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3)
Ankara Medical Journal     Open Access   (Followers: 2)
Ankara Üniversitesi Tıp Fakültesi Mecmuası     Open Access  
Annales de Pathologie     Full-text available via subscription  
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 3)
Annals of African Medicine     Open Access   (Followers: 1)
Annals of Anatomy - Anatomischer Anzeiger     Hybrid Journal   (Followers: 2)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 17)
Annals of Biomedical Sciences     Full-text available via subscription   (Followers: 3)
Annals of Clinical Microbiology and Antimicrobials     Open Access   (Followers: 11)
Annals of Family Medicine     Open Access   (Followers: 14)
Annals of Health Research     Open Access  
Annals of Ibadan Postgraduate Medicine     Open Access  
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Medicine     Hybrid Journal   (Followers: 12)
Annals of Medicine and Surgery     Open Access   (Followers: 7)
Annals of Microbiology     Hybrid Journal   (Followers: 11)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Rehabilitation Medicine     Open Access  
Annals of Saudi Medicine     Open Access  
Annals of the New York Academy of Sciences     Hybrid Journal   (Followers: 5)
Annals of The Royal College of Surgeons of England     Full-text available via subscription   (Followers: 3)
Annual Reports in Medicinal Chemistry     Full-text available via subscription   (Followers: 7)
Annual Reports on NMR Spectroscopy     Full-text available via subscription   (Followers: 4)
Annual Review of Medicine     Full-text available via subscription   (Followers: 17)
Anthropological Review     Open Access   (Followers: 23)
Anthropologie et santé     Open Access   (Followers: 5)
Antibiotics     Open Access   (Followers: 9)
Antibodies     Open Access   (Followers: 2)
Antibody Technology Journal     Open Access   (Followers: 1)
Anuradhapura Medical Journal     Open Access  
Anwer Khan Modern Medical College Journal     Open Access   (Followers: 2)
Apmis     Hybrid Journal   (Followers: 1)
Apparence(s)     Open Access   (Followers: 1)
Applied Clinical Informatics     Hybrid Journal   (Followers: 2)
Applied Clinical Research, Clinical Trials and Regulatory Affairs     Hybrid Journal  
Applied Medical Informatics     Open Access   (Followers: 10)
Arab Journal of Nephrology and Transplantation     Open Access   (Followers: 1)
Arak Medical University Journal     Open Access  
Archive of Clinical Medicine     Open Access   (Followers: 1)
Archive of Community Health     Open Access   (Followers: 1)
Archives Medical Review Journal / Arşiv Kaynak Tarama Dergisi     Open Access  
Archives of Medical and Biomedical Research     Open Access   (Followers: 3)
Archives of Medical Laboratory Sciences     Open Access   (Followers: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Medicine and Surgery     Open Access  
Archives of Trauma Research     Open Access   (Followers: 3)
Archivos de Medicina (Manizales)     Open Access  
ArgoSpine News & Journal     Hybrid Journal  
Arquivos Brasileiros de Oftalmologia     Open Access   (Followers: 1)
Arquivos de Ciências da Saúde     Open Access  
Arquivos de Medicina     Open Access  
Ars Medica : Revista de Ciencias Médicas     Open Access  
ARS Medica Tomitana     Open Access   (Followers: 1)
Art Therapy: Journal of the American Art Therapy Association     Full-text available via subscription   (Followers: 13)
Arterial Hypertension     Open Access   (Followers: 1)
Artificial Intelligence in Medicine     Hybrid Journal   (Followers: 14)
Artificial Organs     Hybrid Journal   (Followers: 1)
ASHA Leader     Open Access  
Asia Pacific Family Medicine     Open Access   (Followers: 1)
Asia Pacific Journal of Clinical Nutrition     Full-text available via subscription   (Followers: 10)
Asia Pacific Journal of Clinical Trials : Nervous System Diseases     Open Access  
Asian Bioethics Review     Full-text available via subscription   (Followers: 3)
Asian Biomedicine     Open Access   (Followers: 2)
Asian Journal of Cell Biology     Open Access   (Followers: 5)
Asian Journal of Health     Open Access   (Followers: 3)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 4)
Asian Journal of Medical and Pharmaceutical Researches     Open Access   (Followers: 1)
Asian Journal of Medical Sciences     Open Access   (Followers: 2)
Asian Journal of Scientific Research     Open Access   (Followers: 3)
Asian Journal of Transfusion Science     Open Access   (Followers: 1)
Asian Medicine     Hybrid Journal   (Followers: 5)
Asian Pacific Journal of Cancer Prevention     Open Access  
ASPIRATOR : Journal of Vector-borne Disease Studies     Open Access  
Astrocyte     Open Access  
Atención Familiar     Open Access  
Atención Primaria     Open Access   (Followers: 1)
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche     Open Access  
Audiology - Communication Research     Open Access   (Followers: 10)
Auris Nasus Larynx     Full-text available via subscription  
Australian Coeliac     Full-text available via subscription   (Followers: 1)
Australian Family Physician     Full-text available via subscription   (Followers: 3)
Australian Journal of Medical Science     Full-text available via subscription   (Followers: 1)
Autopsy and Case Reports     Open Access  
Avicenna     Open Access   (Followers: 3)
Avicenna Journal of Clinical Medicine     Open Access  
Avicenna Journal of Medicine     Open Access   (Followers: 1)
Bangabandhu Sheikh Mujib Medical University Journal     Open Access   (Followers: 1)
Bangladesh Journal of Anatomy     Open Access   (Followers: 1)
Bangladesh Journal of Bioethics     Open Access  
Bangladesh Journal of Medical Biochemistry     Open Access   (Followers: 4)

        1 2 3 4 5 6 7 8 | Last

Journal Cover
African Journal of Biomedical Research
Journal Prestige (SJR): 0.145
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1119-5096
Published by African Journals Online Homepage  [265 journals]
  • Protective effect of Carica papaya fruit extract against gamma
           

    • Authors: I.O. Imosemi, I.S. Owolabi, O Owoeye, A.O. Malomo
      Abstract: Radiation side effects have been reported to induce oxidative stress by free radical generation. The protective effect of Carica papaya (CP) fruit extract, vitamins C and E against gamma radiation-induced oxidative damage on postnatal developing rat cerebellum was studied. Forty-two female Wistar rats were mated and divided into six groups (n=7). Group A served as control and received water, Group B received a dose of 2.5 Gy irradiation only, Group C received 200 mg/kg aqueous extract of CP only, Group D received 200 mg/kg aqueous extract of CP + 2.5 Gy irradiation, Group E received 500mg/kg Vitamin E + 2.5 Gy irradiation and Group F received 200 mg/kg Vitamin C + 2.5 Gy irradiation. The pregnant rats were exposed to irradiation with radiation from Cobalt 60 delivered by an AECL machine in prone position on 7th day of pregnancy, while aqueous extract of CP, Vitamin E and Vitamin C were administered orally from day 7 of gestation to postnatal day 28. Behavioural and haematological assessments of pups were done on day 21, and killed. Some cerebella of the pups of days 1, 7 14 21 and 28 were fixed in 10% formol-saline for histological and histomorphometric studies, while other cerebella of day 21 were preserved in phosphate buffered saline at 4oC and pH 7.4 for biochemical assays. Data were presented as Mean ± Standard Deviation and analysed using ANOVA at p < 0.05. Results showed in the irradiated rats, a significant reduction in body weight, increased brain weight, decreased time spent on the forelimb grip, decreased haemoglobin (Hb) concentration and increased lipid peroxidation (LPO) and H2O2 levels in the cerebellum compared with the control, CP, vitamins C and E rats at p<0.05. Histologically, there was persistent external granular layer (EGL) as well as reduction in molecular layer (ML) thickness in the irradiated group compared with the control and other treated groups on postnatal day 21. In conclusion, 2.5 Gy whole body irradiation of pregnant rats induced oxidative stress in the developing rat cerebellum. Treatment, with aqueous extract of CP reduced the damage caused by irradiation when compared with vitamins C and E.Keywords: Oxidative stress, gamma- radiation, Carica papaya, developing cerebellum
      PubDate: 2018-02-01
      Issue No: Vol. 21, No. 1 (2018)
       
  • Phytochemical analysis and evaluation of antidiabetic effects in
           alloxan-induced diabetic rats treated with aqueous leaf extract of
           Acanthospermum hispidum

    • Authors: A Chika, D.C. Onyebueke, S.O. Bello
      Abstract: The current study is aimed at investigating the antidiabetic activity of the leaves of Acanthospermum hispidum, a medicinal plant traditionally used to treat diabetes mellitus in North Western Nigeria. Material from the plant was extracted using water (guided by the traditional mode of extraction) and the phytochemicals contained in the extract were analyzed qualitatively and quantitatively. Acute toxicity study of the extract was conducted, and diabetic rats induced using alloxan (80 mg/kg administered intraperitoneally once daily for 3 days) were treated with the extract for 28 days at 3 incremental doses (70, 210 and 700 mg/kg). At the end of the experiment, fasting blood glucose and glycogen content of the liver and skeletal muscle were determined. The study findings indicate that the extract was relatively safe with LD50 above 5000 mg/kg. Treatment with Acanthospermum hispidum extract resulted in a significant (P<0.05) reduction in FBG as well as a significant improvement in oral glucose tolerance at all doses. A significant elevation in the hepatic content of glycogen was also observed at the highest dose (700 mg/kg). Results from this study have demonstrated the potent antidiabetic activity of the aqueous extract of the leaves of Acanthospermum hispidum, thus justifying the traditional claim.Keywords:  Acanthospermum, phytochemicals, antidiabetic, LD50, aqueous extract
      PubDate: 2018-02-01
      Issue No: Vol. 21, No. 1 (2018)
       
  • Erratum: Unripe Musa paradisiaca Fruit Diet Ameliorates Impaired Glucose
           Regulation Caused by Iron-Induced Oxidative Stress. Afr. J. Biomed. Res.
           2017: 20(3):301-308

    • Authors: Samuel B. Olaleye
      Abstract: In the article “Unripe Musa paradisiaca Fruit Diet Ameliorates Impaired Glucose Regulation Caused by Iron-Induced Oxidative Stress” by Ige A.O, Oyekunle A.O, Olaoye M. O and Adewoye E.O which appeared on pages 301-308 of the September 2017 issue, it has been observed that the name of the second author was wrongly typed.The correct authorship of the paper should be Ige A.O, Ojekunle A.O, Olaoye M. O and Adewoye E.O.
      PubDate: 2018-02-01
      Issue No: Vol. 21, No. 1 (2018)
       
  • Predatory publishing and the dilemma of the Nigerian Academic

    • Authors: G.A. Ajuwon, A.J. Ajuwon
      Abstract: Publication through the open access model has provided unrestricted global access to the latest scientific findings to anyone who has access to the internet. Although open access publishing was originally promoted because of the ‘public good’ it promises to deliver, concerns are being raised about this mode of publishing because of the emergence of dubious practices by publishers whose primary interest is profit and not the promotion of access to scientific knowledge. Predatory open access publishing is a phenomenon widespread in developing countries. This article summarizes the published literature on predatory open access publishing, discusses its potential impact on scholarship in Nigeria and offers suggestions to address the problem.Keywords: Predatory publishing, Open Access, Nigerian academic, Journals
      PubDate: 2018-01-31
      Issue No: Vol. 21, No. 1 (2018)
       
  • BRCA1 and BRCA2 gene mutations in breast cancer among west African women

    • Authors: A.A. Zouré, H.A. Bambara, A.Y. Sawadogo, Y Bakri, J Simporé
      Abstract: There is an increase in the prevalence of cancer in Africa, while cancer was previously related to the industrialized countries. In fact, until today studies are scanty in all the African regions to find out more about the reality of the disease. However, in West Africa, there are few reports on the genetic factors of breast cancer. Our review was able to establish that very few studies have described the mutations of the BRCA1 / 2 genes in Africa. The dearth of scientific data in West Africa has impacted negatively on prevention, sensitization and management of breast cancer. We strongly suggest studies in general cancer registries of these countries and particularly on the genetic etiology of breast cancerKeywords: Breast cancer- Genetic risks- BRCA1/2- West Africa
      PubDate: 2018-01-31
      Issue No: Vol. 21, No. 1 (2018)
       
  • Assessment of programmed cell death proteins in oral squamous cell
           carcinoma

    • Authors: S.E. Udeabor, A.O. Adisa, A Orlowska, R.A. Sader, S Ghanaati
      Abstract: Oral squamous cell carcinoma (OSCC) is a significant health concern in Nigeria and although the prevalence is relatively low compared to other populations, late patient presentation, yet to be clearly defined etiology and inadequate facilities for management result in high mortality rates. Chronic inflammation, which borders on immunological concepts of cancer biology have been proposed as contributory. Seeing that immunology is a ‘double-edged sword’ that can be manipulated for therapy, it is needful to explore this model in OSCC found in Nigerian patients. We aim to investigate the expression of and relationship between PD-1, PD-L1 and PD-L2 in OSCC. This is important because there are now immunotherapies that target the cell programmed death pathway. Twenty FFPE blocks of OSCC were prepared for immunohistochemistry to Abcam Mouse monoclonal Anti-PD1 antibody, Rabbit monoclonal Anti-PD-L1 antibody and Rabbit Polyclonal Anti-PD-L2. Cytoplasmic/membrane staining was taken as positive for the antibodies. The Sinicrope scoring method was used to evaluate staining intensity and proportion. We found that tumor associated macrophages and neoplastic cells expressed PD1, PD-L1 and PD-L2 in differing proportions, but most of the cases were negative for these antibodies. Our results have shown that immunotherapy may be relevant when considering the management of OSCC patients in Nigeria.Keywords: programmed cell death, oral squamous cell carcinoma
      PubDate: 2018-01-31
      Issue No: Vol. 21, No. 1 (2018)
       
  • Detection, inhibition and molecular analysis of multidrug resistant
           aerobic gram-negative clinical isolates from a tertiary hospital in
           Nigeria

    • Authors: A.O. Adeluola, K.S. Oyedeji, U.E. Mendie, J.R. Johnson, J.R. Porter
      Abstract: The challenge of combating the ever emerging multi-drug resistant (MDR) clinical isolates in the face of a slow rate of discovery of new classes of antibiotics is a problem in antibiotic chemotherapy. This study was aimed at (i) linking phenotypic antibiotic drug-resistance characteristics detected in randomly-sampled clinical isolates with detectable genetic markers. (ii) screening a suspected efflux pump inhibitor (EPI) [1-(3-(trifluoromethyl)benzyl]-piperazine (TFMBP)], which could be helpful in combating this challenge. Fifty-one isolates; 28 Klebsiella pneumonia, 3 E. Coli, 1 Enterobacter cloacae, 1 E. aerogenes, 5 Proteus mirabilis, 4 Providencia rettgeri, 1 P. stuartii, 1 Serratia liquefaciens, 6 S. odorifera, and 1 Acinetobacter baumannii obtained from infections of urinary tract, upper respiratory tract, gastrointestinal tract, ear swab, eye swab, and blood culture were screened for (i) antibiotic-susceptibility over a range of 11 classes of antibiotics, (ii) β-lactamase production, (iii) ESBL production and (iv) Efflux pump activity (EPA) in the presence and absence of 1-[3-(trifluoromethyl) benzyl]-piperazine (TFMBP). Molecular analysis was done using DNA extraction by boiling and the randomly-amplified polymorphic DNA (RAPD) polymerase chain reaction (PCR) procedure with 2% agarose gel electrophoresis stained with ethidium bromide at 10 μg/ml and visualized by UV trans-illumination. AmpC β-lactamase (4%) and K1 β-lactamase (5.8%) were detected with no carbapenemase producers. AcrA and AcrB marker genes were detected in 12% of the isolates while blaCTX-M (8%) and blaTEM (4%) were also detected. Antibiotic resistance due to EPA can be combated with a suitable EPI as demonstrated by TFMBP when combined with specific antibiotics.Keywords: TFMBP, Efflux Pump Activity, ESBL, MDR, Carbapenemase
      PubDate: 2018-01-31
      Issue No: Vol. 21, No. 1 (2018)
       
  • Onchocercal DNA amplification using beta actin gene primers compared with
           first internal transcribed spacer sequences for monitoring onchocerciasis
           eradication strategy

    • Authors: H.O. Osue, H.I. Inabo, S.E. Yakubu, P.A. Audu, M Mamman
      Abstract: Ongoing treatment control strategy against onchocerciasis or river blindness will need efficient diagnostic method to evaluate the mass drug administration with ivermectin (Mectizan®). Sole reliance on classical parasitological method of skin snip microscopy for detecting microfilaria has proved less sensitive during post-control period. Detecting any parts of the parasite stages such as antigens, enzymes and nucleic acids (DNA and RNA) is a definitive diagnosis and highly sensitive. This study was to evaluate the diagnostic reliability of the beta actin gene primer pair to confirm its suitability for validating presence or absence of skin microfilaria at post-treatment. DNA extracted from skin snip samples (n=15) from an onchocerciasis mesoendemic area, three from non-endemic, two adult worm fragments and blank wells with only master mix (n=7) were subjected to endpoint polymerase chain reaction (PCR) analysis. Four of the samples had shown reactivity with first internal transcribed spacer (ITS1) primer pair. The amplicons were sequenced and subjected to basic local alignment search tool (BLAST). Out of the 12 amplicons in agarose gel, there were 6 sharp and 6 faint bands of 100bp molecular weight as documented. The sharp bands included 3 ITS1 and one field positive samples, and 2 positive controls. The BLAST analysis showed moderate homology with beta actin with accession number M84916 available in the public GenBank database, and with the positive control sequences. This study has shown that DNA amplification with beta actin gene may be very specific and more sensitive compared with the ITS gene primer sequences.Keywords: Beta actin, DNA amplification, Onchocerca volvulus, polymerase chain reaction; sequence alignment, skin microfilaria
      PubDate: 2018-01-31
      Issue No: Vol. 21, No. 1 (2018)
       
  • Dietary pattern, lifestyle and nutritional status of hypertensive
           outpatients attending University College Hospital, Ibadan, Nigeria

    • Authors: O.O. Olaitan, G.T. Fadupin, A.A. Adebiyi
      Abstract: Inappropriate eating habits and sedentary lifestyle predispose to hypertension. This study assessed dietary pattern, lifestyle and nutritional status of hypertensive outpatients attending Cardiology Clinic of University College Hospital, Ibadan. This research was descriptive and cross-sectional, including 92 hypertensive patients (37 males; 55 females). Interviewer-administered and Food Frequency Questionnaires were used for socio-demographic and lifestyle data, and dietary pattern respectively. The patients’ anthropometry was assessed. Mean of their last four blood pressure readings was calculated. Descriptive and inferential statistics were employed at p<0.05. The patients’ mean age was 55.7±13.32 years. Majority were married. Many had secondary and tertiary education. Up to 87.0% did not drink alcohol and 98.9% never smoked cigarette. Most of them worked for 6 days while 53.2% engaged in moderate physical fitness 1-2 days a week but less than 30 minutes per day. Only few (26.1%) received dietary counseling from dietitians. Breakfast was mostly consumed. Half of them cooked their foods at home while others ate with food vendors every week. Fruits and vegetables were rarely consumed. Large number had Body Mass Index ≥ 25kg/m2. BMI of the male and female patients was statistically different (χ2= 10.299, p<0.006). Most females and males of the hypertensive patients had waist-to-hip ratio above cut off points. More than half had uncontrolled blood pressure. Many were young adults and elderly who had not visited dietitians, and did not regularly consume fruits and vegetables. Majority had sedentary lifestyle. Female patients were more obese and overweighed with poor control of hypertension than male patients.Keywords: Dietary pattern, lifestyle, nutrition status, hypertension
      PubDate: 2018-01-31
      Issue No: Vol. 21, No. 1 (2018)
       
  • Knowledge of diets as a modifiable risk factor of obesity among women of
           reproductive age in Ibadan, Nigeria

    • Authors: O.E. Oyewole, Y Ajayi
      Abstract: Knowledge of Women of Reproductive Age (WRA) on diets as a Modifiable Risk Factor (MRF) of obesity was assessed in a descriptive cross-sectional study design. A multi-stage sampling technique and semi-structured, interviewer-administered questionnaire were adopted to elicit information. Knowledge of diets as MRF was assessed on a 12-point scale and poor score was ≤7 while good was >7. Obesity was assessed using Body Mass Index (BMI) and respondents with BMI ≥30kg/m2 were classified as obese. Pattern of consumption of high calorie foods was assessed using a 7-day food frequency questionnaire. Respondents’ age was 29.9±8.7 years and 56.0% had tertiary education. Sixty-two percent had good knowledge of diets as MRF for obesity and prevalence of obesity was 18.6%. Frequently consumed high calorie foods included cocoa-based drinks (24.8%), carbonated sweet drinks (19.6%) and high calorie snacks (15.4%). The MRFs of obesity mentioned by the respondents were bad eating habits, which included frequent consumption of high calorie foods (71.2%), genetic predisposition (48.2%) and inactivity (32.0%). Knowledge of diets as MRF was not significantly associated with BMI at p≤0.05. Respondents aged 30-34 years were more likely to have higher knowledge of healthy eating as MRF of obesity than those aged 15-19 years (OR: 2.6; 95%CI: 1.3–5.2). Despite the awareness on causes of obesity, there was no significant difference between knowledge of diets as risk factors to obesity and BMI. Nutrition education on healthy eating, which encourages consumption of fruits and vegetables and reduced consumption of high calorie foods should be directed at WRA using appropriate health promotion approaches.Keywords: Obesity, Modifiable risk factor, Diets, High calorie foods
      PubDate: 2018-01-31
      Issue No: Vol. 21, No. 1 (2018)
       
  • Neuroprotective potential of Citrullus lanatus seed extract and Vitamin E
           against mercury chloride intoxication in male rat brain

    • Authors: O Owoeye, R.O. Akinbami, M.A. Thomas
      Abstract: Mercury chloride toxicity continues to be relevant in the advent of increased interest in mining activity in Nigeria. The neuroprotective potential of Citrullus lanatus seed extract (CLSE) (Watermelon seed) and vitamin E (VIT E) on mercury chloride intoxication on the frontal cerebral cortex of male rats was investigated. Forty two (42) male rats were randomized into six groups of 7 rats each. Group 1: control group received food and water; Group 2: received CLSE (200 mg/kg); Group 3: received VIT E (500 mg/kg); Group 4: received HgCl2 (4 mg/kg); Group 5: received HgCl2 (4 mg/kg) + VIT E (500 mg/kg) and Group 6: received HgCl2 (4 mg/kg) + CLSE (200 mg/kg). Treatment lasted 14 days and on 15th day of the experiment, gross morphometric, behavioural tests and brain tissue processing using paraffin wax technique were done. While gross body and brain morphometric evaluations were not significantly different, behavioural studies show that CLSE and VIT E significantly (p<0.05) increased the number of lines crossed relative to control. Histology showed that HgCl2 caused degeneration of neurons of the frontal cerebral cortex when compared with the control. Co-treatment of HgCl2 with CLSE and VIT E showed histological features of protection of cerebral neurons from mercury damage. CLSE and VIT E mitigated HgCl2–induced degeneration of frontal cerebral cortical neurons thus demonstrating their neuropotential capacity to protect cerebral cortex neurons from mercury toxicity..Keywords: Citrullus lanatus extract, mercuric chloride, Vitamin E, rat frontal cortex, cortical
      PubDate: 2018-01-31
      Issue No: Vol. 21, No. 1 (2018)
       
  • Sperm morphology and characteristics in male rats treated with leaf
           extract Combretum sordidum

    • Authors: O.A. Oridupa, B.B. Samuel, A.A. Amolegbe
      Abstract: This study assessed the reproductive toxicity potential of Combretum sordidum, a medicinal plant used in West Africa as an antioxidant and antimicrobial recipee. Male Wistar rats (25) were orally administered with the acetone extract of C. sordidum a dose of 100, 200, 400 or 800mg/kg for 14 days. On day 15, the rats were humanely sacrificed and semen samples were collected to determine the sperm morphology and characteristics. Histology of the testes was also carried out to assess for the effect of the extract. The extract caused morphological changes of the sperm cells, predominantly secondary abnormality. Primary abnormality observed was rudimentary tail and secondary abnormalities included bent mid-piece, curved mid-piece, bent tail, curved tail, tail-less head, head-less tail and looped tail. The reduction in primary abnormality as opposed to the increase in secondary abnormalities shows that administration over a period of time does not adversely affect spermatogenesis but causes morphological changes of the spermatozoa during maturation and storage at the epididymis. The reduction in sperm count and motility at high doses are indicative of a decline in sperm quality. Although, these semen parameters fall within the recommended range, chronic administration of the extract of C. sordidum may lead to infertility and further progress to sterility. It is therefore recommended that C. sordidum should not be administered at doses exceeding 200mg/kg and chronic exposure should be avoided in males with reproductive potentials.Keywords: Toxicology, Male reproduction, Combretum sordidum, Wistar rat
      PubDate: 2018-01-31
      Issue No: Vol. 21, No. 1 (2018)
       
  • Humoral immune response of broilers fed with Moringa oleifera supplemented
           

    • Authors: A.G. Balami, P.A. Abdu, A.M. Wakawa, T Aluwong, S.B. Oladele, S.J. Enam
      Abstract: Infectious bursal disease virus has been reported to be one of the very important immunosuppressive agents in poultry. Therefore, the present study was conducted to evaluate the immune modulating effect of Moringa oleifera leaf (MOL) supplemented feed in broilers. Two-hundred-and-forty-day old Ross 308 hybrid broiler chicks were assigned into groups A, B, C and D of 60 chicks each in deep litter type housing. Groups A and B were fed with formulated broiler starter and finisher feeds, containing 5% MOL for 4 and 3 weeks, respectively, while groups C and D were fed with formulated broiler starter and finisher feed without MOL for 4 and 3 weeks, respectively. Broilers in groups A and C were vaccinated intramuscularly with 0.5 ml of inactivated intermediate strain of infectious bursal disease (IBD) vaccine at 14 and 21 days of age, respectively and inactivated Newcastle disease virus (NDV) vaccine (Komorov strain) at 18 days of age, while those in groups B and D served as positive and negative control. Blood was collected from 10 broilers in each group via the wing vein on 14, 21, 35, and 38 days of age to determine the antibody titres of the various groups of broilers using Enzyme linked immunosorbent assay (ELISA). Significant decrease (p = 0.001) was observed in the mean IBD antibody titre of birds in group A at 21 days of age and significant increase at 35 days of age. Birds in group B showed a significant decrease (p = 0.000) in antibody mean titre at 21 days of age and a significant (P = 0.002) increase at 35, 38 and 42 days of age. Significant decrease (p = 0.000) was observed in the mean antibody titre of broilers in group C at 21 days of age and a significant increase (p = 0.022) was observed at 35 days of age. The antibody mean titre of broilers in group D showed a significant decrease (p = 0.000) at 21 days of age, and a significant (p = 0.000) increase at 35 days of age. Broilers fed with MOL supplemented diet need to be vaccinated to have a high antibody titre against IBD.Keywords: Broilers, Moringa oleifera leaf, IBD, Antibody
      PubDate: 2018-01-31
      Issue No: Vol. 21, No. 1 (2018)
       
  • Dental formula and dental abnormalities observed in the Eidolon helvum
           (Fruit Bat) captured from the wild

    • Authors: O Igado, O Femi-Akinlosotu, T Omobowale, R Ajadi, H Nottidge
      Abstract: Bats are known to be the only flying mammals. Eidolon helvum is a species of fruit bats that is reported to have great economic and health importance, while also having an unsavoury reputation in many cultures in Nigeria. This study investigated the dental formula and dental pathologies of Eidolon helvum captured from the wild. The dental profile of 35 adult bats (20 males, 15 females) was assessed. The animals were observed to have a heterodont dentition. The males were observed to have a total of 30 to 36 teeth, while the females had 30 to 34 teeth. A missing lower incisor was observed in some of the females while the males showed a varying number of upper premolar. Severe attrition and edentulousness were observed in some bats examined. Results obtained from this work may shed more light on the different dental pathologies observed in the adult Eidolon helvum in Nigeria.Keywords:  Eidolon helvum, dental formula, dental abnormalities, attrition
      PubDate: 2018-01-31
      Issue No: Vol. 21, No. 1 (2018)
       
  • Protective effects of aqueous extract of Citrullus lanatus fruit on
           reproductive functions and antioxidant activities in arsenic-treated male
           wistar rats

    • Authors: O.O. Daramola, W.A. Oyeyemi, F.U. Beka, E.A. Ofutet
      Abstract: Arsenic trioxide (As2O3), a known male reproductive toxicant induces it effects majorly through oxidative stress. Citrullus lanatus fruit is widely consumed for its high medicinal values and antioxidant capacities. This study investigated the effects of aqueous extract of Citrullus lanatus fruit (AECL) on reproductive functions and antioxidant activities in arsenic-treated male Wistar rats. Thirty male Wistar rats (150-190 g) were grouped into six and treated as follows; Control, 3 mg/kg As2O3, 100 mg/kg AECL, 200 mg/kg AECL, As2O3+100 mg/kg AECL and As2O3+200 mg/kg AECL. All administration was done orally for thirty days. Caudal sperm, serum hormone levels and testicular antioxidant activities were evaluated. Decreases (p<0.05) in sperm concentration, morphology, viability, and motility were observed in As2O3 group, however, AECL co-administered with As2O3 significantly reversed these effects. Follicle stimulating hormone decreased (p<0.05) in As2O3 group compared with control while significant increase was observed in groups co-treated with AECL and As2O3 relative to As2O3 group. There was an increase (p<0.05) in malondialdehyde level in As2O3 group compared with control while a decrease (p<0.05) was observed in groups co-treated with AECL and As2O3 compared with the As2O3 group. Superoxide dismutase activities decreased (p<0.05) in As2O3 group compared with control but increased (p<0.05) in 200 mg/kg AECL+As2O3 group relative to As2O3 group. Immature spermatids were observed in the seminiferous tubules of As2O3 group, while AECL improved the histology when compared with As2O3 group. The results of this study suggest that aqueous extract of Citrullus lanatus provides protection for sperm cells against arsenic-induced oxidative stress.Keywords:  Eidolon helvum, dental formula, dental abnormalities, attrition
      PubDate: 2018-01-31
      Issue No: Vol. 21, No. 1 (2018)
       
  • Haematological effects of leaf extract of Moringa oleifera Lam in normal
           and myelo-suppressed wistar rats

    • Authors: S.A. Ufelle, K.C. Onyekwelu, P.U. Achukwu, C.O. Ezeh, S Ghasi
      Abstract: Haematological effects of leaves extract of Moringa oleifera Lam were investigated in normal and myelo-suppressed Wistar rats. Acute toxicity and phytochemistry of Moringa oleifera were determined. Wistar-rats (n=35), aged 2 to 3 months, weighing 120 - 170 grams were divided into 5 groups of 7 rats per group, labeled A to E. Groups A and B were induced intraperitoneally with 3mg/kg body weight (b.wt) of cyclophosphamide for 7 days to achieve myelo-suppression. Groups A, B, C and D were orally administered with graded-doses of the extract (A=150, B=300, C=150 and D=300 mg/kg body weight) for 14 days. Group E served as control. Blood samples (3.0 ml) were collected on days 8 and 15 from each rat through the retro orbital plexus of the median canthus into tri-potassium ethylene diamine tetra acetic acid containers and analyzed using haematological auto analyzer (Sysmex KX-21N) following manufacturers guideline. The acute toxicity test of Moringa oleifera leaves revealed an oral LD50 of 3000 mg/kg body weight. Its phytochemical analyses revealed flavonoids ++, alkaloids ++, saponins +, tannins +, proteins ++, carbohydrate +, reducing ssugars +, steroids ++ and terpenoids +. On days 8 and 15 respectively, haemoglobin, haematocrit and total white blood cells of groups C, D and RBC of group D increased significantly (p < 0.05) when compared with the control. Groups A and B revealed dose- and time-dependent non-significant increases (p >0.05) in haemoglobin, haematocrit, red blood cells and total white blood cells on day 15 when compared with day 8.Keywords:  Moringa oleifera, toxicity, phytochemical, myelo-suppression
      PubDate: 2018-01-01
      Issue No: Vol. 21, No. 1 (2018)
       
 
 
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