Subjects -> MEDICAL SCIENCES (Total: 8669 journals)
    - ANAESTHESIOLOGY (120 journals)
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    - MEDICAL SCIENCES (2406 journals)
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    - SPORTS MEDICINE (81 journals)
    - SURGERY (406 journals)

MEDICAL SCIENCES (2406 journals)            First | 1 2 3 4 5 6 7 8 | Last

Showing 201 - 400 of 3562 Journals sorted alphabetically
Asian Biomedicine     Open Access   (Followers: 2)
Asian Journal of Cell Biology     Open Access   (Followers: 6)
Asian Journal of Health     Open Access   (Followers: 3)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 5)
Asian Journal of Medical and Pharmaceutical Researches     Open Access   (Followers: 2)
Asian Journal of Medical Sciences     Open Access   (Followers: 2)
Asian Journal of Medicine and Health     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access   (Followers: 1)
Asian Journal of Scientific Research     Open Access   (Followers: 3)
Asian Journal of Transfusion Science     Open Access   (Followers: 1)
Asian Medicine     Hybrid Journal   (Followers: 5)
Asian Pacific Journal of Cancer Prevention     Open Access  
Asian Pacific Journal of Health Sciences     Open Access   (Followers: 10)
ASPIRATOR : Journal of Vector-borne Disease Studies     Open Access  
Astrocyte     Open Access  
Atención Familiar     Open Access  
Atención Primaria     Open Access   (Followers: 2)
Atención Primaria Práctica     Open Access   (Followers: 1)
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche     Open Access  
Audiology - Communication Research     Open Access   (Followers: 10)
AUP Advances     Open Access   (Followers: 7)
Auris Nasus Larynx     Full-text available via subscription  
Australasian Journal of Ultrasound in Medicine (AJUM)     Hybrid Journal   (Followers: 1)
Australian Coeliac     Full-text available via subscription   (Followers: 2)
Australian Family Physician     Full-text available via subscription   (Followers: 3)
Australian Journal of Medical Science     Full-text available via subscription   (Followers: 3)
Autopsy and Case Reports     Open Access  
Avicenna     Open Access   (Followers: 3)
Avicenna Journal of Clinical Medicine     Open Access  
Avicenna Journal of Medicine     Open Access   (Followers: 1)
Bangabandhu Sheikh Mujib Medical University Journal     Open Access   (Followers: 1)
Bangladesh Journal of Anatomy     Open Access   (Followers: 2)
Bangladesh Journal of Bioethics     Open Access  
Bangladesh Journal of Medical Biochemistry     Open Access   (Followers: 4)
Bangladesh Journal of Medical Education     Open Access   (Followers: 2)
Bangladesh Journal of Medical Microbiology     Open Access   (Followers: 4)
Bangladesh Journal of Medical Physics     Open Access   (Followers: 1)
Bangladesh Journal of Medical Science     Open Access  
Bangladesh Journal of Medicine     Open Access   (Followers: 1)
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Bangladesh Journal of Scientific Research     Open Access   (Followers: 1)
Bangladesh Medical Journal     Open Access  
Bangladesh Medical Journal Khulna     Open Access  
Basal Ganglia     Hybrid Journal  
Basic Sciences of Medicine     Open Access   (Followers: 1)
Batı Karadeniz Tıp Dergisi / Medical Journal of Western Black Sea     Open Access  
Baylor University Medical Center Proceedings     Hybrid Journal  
BBA Clinical     Open Access  
BC Medical Journal     Free  
Benha Medical Journal     Open Access  
Beni-Suef University Journal of Basic and Applied Sciences     Open Access   (Followers: 3)
Bijblijven     Hybrid Journal  
Bijzijn     Hybrid Journal   (Followers: 1)
Bijzijn XL     Hybrid Journal  
Bio-Algorithms and Med-Systems     Hybrid Journal   (Followers: 2)
BioDiscovery     Open Access   (Followers: 2)
Bioelectromagnetics     Hybrid Journal   (Followers: 2)
Bioelectronic Medicine     Open Access   (Followers: 1)
Bioengineering & Translational Medicine     Open Access  
Bioethics     Hybrid Journal   (Followers: 19)
Bioethics Research Notes     Full-text available via subscription   (Followers: 15)
Biologics in Therapy     Open Access  
Biology of Sex Differences     Open Access   (Followers: 2)
Biomarker Research     Open Access   (Followers: 3)
Biomarkers in Medicine     Hybrid Journal   (Followers: 2)
BioMed Research International     Open Access   (Followers: 5)
Biomédica     Open Access  
Biomedical & Life Sciences Collection     Full-text available via subscription   (Followers: 3)
Biomedical and Biotechnology Research Journal     Open Access   (Followers: 1)
Biomedical Engineering     Hybrid Journal   (Followers: 16)
Biomedical Engineering and Computational Biology     Open Access   (Followers: 13)
Biomedical Engineering Letters     Hybrid Journal   (Followers: 6)
Biomedical Engineering Research     Open Access   (Followers: 7)
Biomedical Informatics Insights     Open Access   (Followers: 9)
Biomedical Journal     Open Access   (Followers: 4)
Biomedical Materials     Hybrid Journal   (Followers: 7)
Biomedical Microdevices     Hybrid Journal   (Followers: 9)
Biomedical Optics Express     Open Access   (Followers: 6)
Biomedical Photonics     Open Access  
Biomedical Reports     Full-text available via subscription  
Biomedical Research Reports     Full-text available via subscription   (Followers: 2)
Biomedical Safety & Standards     Full-text available via subscription   (Followers: 9)
Biomedical Science and Engineering     Open Access   (Followers: 7)
BioMedicine     Open Access  
Biomedicine Hub     Open Access  
Biomedicines     Open Access   (Followers: 1)
Biomedika     Open Access  
Biomolecular and Health Science Journal     Open Access   (Followers: 1)
Biophysics Reports     Open Access  
BioPsychoSocial Medicine     Open Access   (Followers: 8)
Biosafety and Health     Open Access   (Followers: 2)
Biosalud     Open Access   (Followers: 1)
Biostatistics & Epidemiology     Hybrid Journal   (Followers: 2)
Birat Journal of Health Sciences     Open Access  
BIRDEM Medical Journal     Open Access   (Followers: 1)
Birth Defects Research     Hybrid Journal  
Birth Defects Research Part A : Clinical and Molecular Teratology     Hybrid Journal   (Followers: 3)
Birth Defects Research Part C : Embryo Today : Reviews     Hybrid Journal  
BJR|Open     Open Access   (Followers: 1)
BJS Open     Open Access   (Followers: 1)
Black Sea Journal of Health Science     Open Access  
BLDE University Journal of Health Sciences     Open Access  
Blickpunkt Medizin     Hybrid Journal  
BMC Biomedical Engineering     Open Access  
BMC Medical Ethics     Open Access   (Followers: 22)
BMC Medical Research Methodology     Open Access   (Followers: 9)
BMC Medicine     Open Access   (Followers: 14)
BMC Obesity     Open Access   (Followers: 7)
BMC Proceedings     Full-text available via subscription   (Followers: 2)
BMC Research Notes     Open Access   (Followers: 4)
BMC Sports Science, Medicine and Rehabilitation     Open Access   (Followers: 34)
BMH Medical Journal     Open Access   (Followers: 2)
BMI Journal : Bariátrica & Metabólica Iberoamericana     Open Access  
BMJ     Hybrid Journal   (Followers: 1886)
BMJ Case Reports     Hybrid Journal   (Followers: 28)
BMJ Evidence-Based Medicine     Hybrid Journal   (Followers: 4)
BMJ Global Health     Open Access   (Followers: 3)
BMJ Innovations     Hybrid Journal   (Followers: 6)
BMJ Leader     Hybrid Journal  
BMJ Open     Open Access   (Followers: 44)
BMJ Open Quality     Open Access   (Followers: 19)
BMJ Open Science     Open Access   (Followers: 1)
BMJ Sexual & Reproductive Health     Hybrid Journal   (Followers: 2)
BMJ Surgery, Interventions, & Health Technologies     Open Access  
Bodine Journal     Open Access  
Boletín del Consejo Académico de Ética en Medicina     Open Access  
Boletín del ECEMC     Open Access  
Boletin Médico de Postgrado     Open Access  
Boletín Médico del Hospital Infantil de México     Open Access  
Bone     Hybrid Journal   (Followers: 18)
Bone and Tissue Regeneration Insights     Open Access   (Followers: 2)
Bone Marrow Research     Open Access   (Followers: 2)
Bone Reports     Open Access  
Bosnian Journal of Basic Medical Sciences     Open Access  
Bozok Tıp Dergisi / Bozok Medical Journal     Open Access  
Brachytherapy     Full-text available via subscription   (Followers: 6)
Brain and Development     Full-text available via subscription   (Followers: 5)
Brain Communications     Open Access   (Followers: 2)
Brain Connectivity     Hybrid Journal   (Followers: 5)
Brain Impairment     Full-text available via subscription   (Followers: 2)
Brazilian Journal of Medical and Biological Research     Open Access  
Brazilian Journal of Medicine and Human Health     Open Access  
Brazilian Journal of Pain (BrJP)     Open Access  
Brazilian Journal of Physical Therapy     Open Access   (Followers: 2)
Breastfeeding Review     Full-text available via subscription   (Followers: 19)
British Journal of Biomedical Science     Full-text available via subscription   (Followers: 7)
British Journal of General Practice     Full-text available via subscription   (Followers: 39)
British Journal of Hospital Medicine     Full-text available via subscription   (Followers: 16)
British Medical Bulletin     Hybrid Journal   (Followers: 6)
Buddhachinaraj Medical Journal     Open Access  
Bulletin Amades     Open Access  
Bulletin de la Société de pathologie exotique     Hybrid Journal   (Followers: 1)
Bulletin of Legal Medicine     Open Access  
Bulletin of Medical Sciences     Open Access  
Bulletin of the History of Medicine     Full-text available via subscription   (Followers: 21)
Bulletin of the Menninger Clinic     Full-text available via subscription  
Bulletin of The Royal College of Surgeons of England     Free  
Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products     Open Access  
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz     Hybrid Journal   (Followers: 6)
Burapha Journal of Medicine     Open Access  
Burns     Hybrid Journal   (Followers: 10)
Cadernos de Naturologia e Terapias Complementares     Open Access   (Followers: 1)
Calcified Tissue International     Hybrid Journal   (Followers: 2)
Canadian Bulletin of Medical History     Hybrid Journal  
Canadian Family Physician     Partially Free   (Followers: 13)
Canadian Journal of Pain     Open Access   (Followers: 2)
Canadian Journal of Rural Medicine     Full-text available via subscription   (Followers: 1)
Canadian Medical Association Journal     Open Access   (Followers: 18)
Canadian Medical Education Journal     Open Access   (Followers: 10)
Canadian Prosthetics & Orthotics Journal     Open Access  
Cannabis and Cannabinoid Research     Hybrid Journal   (Followers: 1)
Cardiac Electrophysiology Clinics     Full-text available via subscription   (Followers: 1)
Care Management Journals     Hybrid Journal   (Followers: 5)
Case Reports     Open Access  
Case Reports in Acute Medicine     Open Access   (Followers: 2)
Case Reports in Clinical Medicine     Open Access   (Followers: 2)
Case Reports in Clinical Nutrition     Open Access   (Followers: 1)
Case Reports in Clinical Pathology     Open Access   (Followers: 1)
Case Reports in Medicine     Open Access   (Followers: 3)
Case Reports in Transplantation     Open Access  
Case Reports in Vascular Medicine     Open Access  
Case Reports in Women's Health     Open Access   (Followers: 4)
Case Study and Case Report     Open Access   (Followers: 5)
CASUS : Revista de Investigación y Casos en Salud     Open Access   (Followers: 1)
CBU International Conference Proceedings     Open Access   (Followers: 3)
Cell & Bioscience     Open Access   (Followers: 6)
Cell Adhesion & Migration     Open Access   (Followers: 9)
Cell and Molecular Response to Stress     Full-text available via subscription   (Followers: 2)
Cell and Tissue Transplantation and Therapy     Open Access   (Followers: 2)
Cell Cycle     Full-text available via subscription   (Followers: 6)
Cell Death and Differentiation     Hybrid Journal   (Followers: 8)
Cell Death Discovery     Open Access   (Followers: 1)
Cell Health and Cytoskeleton     Open Access   (Followers: 1)
Cell Medicine     Open Access   (Followers: 6)
Cell Research     Hybrid Journal   (Followers: 8)
Cell Transplantation     Open Access   (Followers: 4)
CEN Case Reports     Hybrid Journal  
Central African Journal of Medicine     Full-text available via subscription  
Cephalalgia Reports     Open Access   (Followers: 2)
Ceylon Journal of Medical Science     Open Access  

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Similar Journals
Journal Cover
Biomedical Journal
Journal Prestige (SJR): 0.674
Citation Impact (citeScore): 2
Number of Followers: 4  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2319-4170 - ISSN (Online) 2320-2890
Published by Elsevier Homepage  [3207 journals]
  • Effects of oral zinc supplementation on patients with noise-induced
           hearing loss associated tinnitus: A clinical trial

    • Abstract: Publication date: Available online 20 March 2019Source: Biomedical JournalAuthor(s): Chun-Wei Yeh, Leng-Hsuan Tseng, Chao-Hui Yang, Chung-Feng HwangAbstractBackgroundZinc plays a vital antioxidant role in human metabolism. Recent studies have demonstrated a correlation between noise-induced hearing loss (NIHL) and oxidative injury; however, no investigation has focused specifically on the subgroup of NIHL associated tinnitus patients. We aimed to evaluate the effectiveness of zinc supplementation in treating NIHL associated tinnitus.MethodsTwenty patients with tinnitus and a typical NIHL audiogram (38 ears) were included in this study. Another 20 healthy subjects were used as the control group. A full medical history assessment was performed, and each subject underwent an otoscopic examination, basic audiologic evaluation, distortion product otoacoustic emissions (DPOAEs), tinnitus-match testing, Tinnitus Handicap Inventory (THI) and serum zinc level analyses. After 2 months of treatment with zinc, all tests were repeated.ResultsThere was a significant difference between pretreatment and post-treatment within the tinnitus group (73.6 vs. 84.6 μg/dl). The pre- and post-treatment difference in serum zinc was significantly higher in the young group (≦50 years) compared to the old group (19.4 ± 11.4 vs. 2.6 ± 9.2 μg/dl, respectively; p = 0.002). There were no statistically significant differences in hearing thresholds, speech reception thresholds, or tinnitus frequency and loudness results before and after treatment. In addition, 17 patients (85%) showed statistically significant improvement of THI-total scores post-treatment, from 38.3 to 30 (p = 0.024).ConclusionsZinc oral supplementation elevated serum zinc levels, especially in younger patients. THI scores improved significantly following zinc treatment in patients with NIHL associated tinnitus. However, no improvements in objective hearing parameters were observed.
  • IFITM3: How genetics influence influenza infection demographically

    • Abstract: Publication date: Available online 20 March 2019Source: Biomedical JournalAuthor(s): Dannielle Wellington, Henry Laurenson-Schafer, Adi Abdel-Haq, Tao DongAbstractThe role of host genetics in influenza infection is unclear despite decades of interest. Confounding factors such as age, sex, ethnicity and environmental factors have made it difficult to assess the role of genetics without influence. In recent years a single nucleotide polymorphism, interferon-induced transmembrane protein 3 (IFITM3) rs12252, has been shown to alter the severity of influenza infection in Asian populations. In this review we investigate this polymorphism as well as several others suggested to alter the host's defence against influenza infection. In addition, we highlight the open questions surrounding the viral restriction protein IFITM3 with the hope that by answering some of these questions we can elucidate the mechanism of IFITM3 viral restriction and therefore how this restriction is altered due to the rs12252 polymorphism.
  • The dual role of innate immunity during influenza

    • Abstract: Publication date: Available online 20 March 2019Source: Biomedical JournalAuthor(s): Carmelo Biondo, Germana Lentini, Concetta Beninati, Giuseppe TetiAbstractOne of the distinguishing features of the 1918 pandemic is the occurrence of massive, potentially detrimental, activation of the innate immune system in critically ill patients. Whether this reflects an intrinsic capacity of the virus to induce an exaggerated inflammatory responses or its remarkable ability to reproduce in vivo is still open to debate. Tremendous progress has recently been made in our understanding of innate immune responses to influenza infection and it is now time to translate this knowledge into therapeutic strategies, particularly in view of the possible occurrence of future outbreaks caused by virulent strains.
  • Evaluation of the fracture resistance of root filled thin walled teeth
           restored with different post systems

    • Abstract: Publication date: Available online 20 March 2019Source: Biomedical JournalAuthor(s): Caner Öztürk, Serdar Polat, Makbule Tunçdemir, Fehmi Gönüldaş, Emre ŞekerAbstractBackgroundRestoration of the teeth with extensive root canals with different post systems is a challenge for clinicians. Evaluation of these systems is important for clinical success. The aim of this study was to compare the fracture resistance and fracture mode of endodontically treated thin-walled teeth which restored with different post systems.MethodsEighty extracted and endodontically treated maxillary canines were divided into 4 groups (n = 20) and the thickness of the radicular dentin walls was reduced by using diamond burs. Each root was embedded in an autopolymerizing resin with a 0.25 mm layer of vinyl polysiloxane material to simulate the periodontal ligament. The subgroups were restored with one of the following post systems: only composite resin (Group 1), cast post (Group 2), glass-fiber post (Group 3), and I-TFC post (Group 4). The samples were subjected to a gradually increasing force (0,5 mm/min). The force required to fracture was recorded, and the data were analyzed with ANOVA, Tukey test's and Chi–Square test (p 
  • Association between periodontal pathogens and systemic disease

    • Abstract: Publication date: Available online 2 March 2019Source: Biomedical JournalAuthor(s): Fiona Q. Bui, Cassio Luiz Coutinho Almeida-da-Silva, Brandon Huynh, Alston Trinh, Jessica Liu, Jacob Woodward, Homer Asadi, David M. OjciusAbstractA growing body of literature suggests that there is a link between periodontitis and systemic diseases. These diseases include cardiovascular disease, gastrointestinal and colorectal cancer, diabetes and insulin resistance, and Alzheimer's disease, as well as respiratory tract infection and adverse pregnancy outcomes. The presence of periodontal pathogens and their metabolic by-products in the mouth may in fact modulate the immune response beyond the oral cavity, thus promoting the development of systemic conditions. A cause-and-effect relationship has not been established yet for most of the diseases, and the mediators of the association are still being identified. A better understanding of the systemic effects of oral microorganisms will contribute to the goal of using the oral cavity to diagnose and possibly treat non-oral systemic disease.
  • Legacy of the influenza pandemic 1918: Introduction

    • Abstract: Publication date: Available online 28 February 2019Source: Biomedical JournalAuthor(s): Siamon Gordon
  • Effects of standardized Zataria multiflora extract and its major
           ingredient, Carvacrol, on Adriamycin-induced hepatotoxicity in rat

    • Abstract: Publication date: December 2018Source: Biomedical Journal, Volume 41, Issue 6Author(s): Reza Mohebbati, Maryam Paseban, Mohammad Soukhtanloo, Mohammad Jalili-Nik, Mohammad Naser Shafei, Amirali Jahani Yazdi, Abolfazl Khajavi RadAbstractBackgroundAt a glance commentaryScientific background on the subjectSince Adriamycin is used as an anticancer drug among various communities and is one of its side-effects, it is important to find a way to prevent this complication. Of these, medicinal plants such as Zataria multiflora can be important in preventing the complications.What this study adds to the fieldThis study shows that carvacrol has a stronger effect on the liver antioxidant system as well as hepatic enzymes activity than the whole plant extract, and then carvacrol can be more helpful than whole plant in the treatment of hepatic damage caused by Adriamycin.Due to antioxidant effects of Zataria multiflora (ZM) and Carvacrol (CAR) in many cases and the prominent role of reactive oxygen species (ROS) in hepatotoxicity induced by Adriamycin (ADR), the aim of this study is to investigate the effects of ZM and CAR on ADR-induced hepatotoxicity.MethodsTwenty four male Wistar rats were randomly divided into four groups including: 1)Control, 2)Adriamycin (ADR), 3,4) ZM + ADR and CAR + ADR that received ZM and CAR for 28 consecutive days. Blood samples were collected on the days 0, 14 and 28 to determine the alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Also, the hepatic redox markers were evaluated.ResultsADR significantly increased ALP, ALT and AST in comparison with the control (p 
  • Basal-bolus or premixed' Shedding light on optimal insulin regime for
           type 1 diabetes

    • Abstract: Publication date: December 2018Source: Biomedical Journal, Volume 41, Issue 6Author(s): Emma Louise WaltonAbstractIn this issue of the Biomedical Journal, we highlight original research that will help to guide the choice of insulin administration regimes for children with type 1 diabetes. We also investigate whether a common medication for attention deficit/hyperactivity disorder worsens sleep problems among these children, and discover a new approach to maximize the lifetime of a fragile piece of surgical equipment.
  • Commentary: Lico A causes ER stress and apoptosis via up-regulating
           miR-144-3p in human lung cancer cell line H292

    • Abstract: Publication date: December 2018Source: Biomedical Journal, Volume 41, Issue 6Author(s): Yuanliang Yan, Zhicheng Gong, Zhijie XuAbstractNatural compound licochalcone A (lico A), a main constituent of flavonoids, has been proved to induce ER stress and apoptosis in cancer cells. However, the underlying anti-tumor mechanism of lico A remains to be clarified in detail. A recently-published report from the journal Frontiers in Pharmacology evaluated the miRNA-based mechanism for lico A on its anti-cancer effect. They found that lico A significantly promoted the tumor-suppressor miR-144-3p expression, so as to up-regulate ER stress-response protein CHOP (CCAAT/-enhancer-binding protein homologous protein) by down-regulating nuclear factor E2-related factor 2 (Nrf2), finally inducing apoptotic cell death in lung cancer. Their findings pave the path toward a more understanding of miRNA-based drugs for cancer treatment in the future.
  • Relationship between sonography of sternocleidomastoid muscle and cervical
           passive range of motion in infants with congenital muscular torticollis

    • Abstract: Publication date: December 2018Source: Biomedical Journal, Volume 41, Issue 6Author(s): Chu-Hsu Lin, Hung-Chih Hsu, Yu-Jen Hou, Kai-Hua Chen, Shang-Hong Lai, Wen-Ming ChangAbstractBackgroundAn abnormal sternocleidomastoid muscle in congenital muscular torticollis can be classified into one of the four types via sonography. However, this categorization lacks quantitative measurements. The purpose of the study was to determine quantitative measurements of the sonograms via image analysis.MethodsInfants younger than 12 months of age suspected of having congenital muscular torticollis were included. Intraclass correlation coefficient estimates for interobserver reliability and a simple regression analysis for criterion validity were calculated. Spearman correlation analysis was then performed. The analyzed parameters included cervical passive range of motion for lateral flexion and rotation, area, brightness, max/min Feret's diameters, and muscular width/thickness.ResultsOf the 29 (4.0 ± 2.6 months) screened infants, 13 (1.9 ± 1.7 months) were included. Nine were male, and 4 were female. Seven infants with mass were ultrasonographically classified into type I, and the other six infants were classified into type II. The affected/unaffected side ratios of cervical passive range of motion for lateral flexion and rotation were 0.92 ± 0.13 and 0.88 ± 0.16, respectively. The parameters measured on the sonograms were reliable, and the max/min Feret's diameters were valid measurements. The affected/unaffected side ratio of cervical passive range of motion for rotation significantly correlated with the affected/unaffected side ratios of the sternocleidomastoid muscle sonogram on area (r = −0.62, p = 0.03) and min Feret's diameter (r = −0.69, p = 0.01).ConclusionsThe area and min Feret's diameter were efficacious parameters for image analysis on sternocleidomastoid sonograms, and the min Feret's diameter would be more suitable than thickness for measuring the thickening SCM in transverse view. A healthy control group, more data and follow-up would be needed to confirm the changes on the SCM sonograms for clinical decision.
  • Surgical technique to achieve high durability of flexible ureteroscopes: A
           single hospital experience

    • Abstract: Publication date: December 2018Source: Biomedical Journal, Volume 41, Issue 6Author(s): Cheng-Chia Lin, Lawrence Shih-Hsin Wu, Shian-Shiang Huang, Cheng-Feng Lin, Wen-Hsiang Chen, Chun-Te WuAbstractBackgroundTo describe a novel operative technique resulting in extended durability and improved ease of use of current flexible ureteroscopes (FURS). A surgical method employing a modified technique of using an Olympus digital flexible URF-V ureteroscope was developed.MethodsWe retrospectively studied 546 patients who underwent retrograde intrarenal surgery (RIRS) using this modified approach performed by a single surgeon at our hospital, and investigated the outcome and durability of the ureteroscope.ResultsThrough the study period, the URF-V ureteroscope required repair five times in total. During factory maintenance, distal working channel damage was noted twice, and outer bending rubber damage was noted once. The most recent two repairs were required due to laser penetration. Despite the damage and repairs, the deflection system was almost entirely intact after high-frequency use. The durability of FURS determines the efficacy of RIRS for renal stones.ConclusionIn this report, we described our modified upside-down technique for manipulation of FURS under unequal dual deflection in order to preserve the deflection apparatus, which yielded a greatly prolonged durability. Additionally, the use of mimic drive turning decreased the time needed to train urologists.
  • Effects of bilateral or unilateral lower body resistance exercises on
           markers of skeletal muscle damage

    • Abstract: Publication date: December 2018Source: Biomedical Journal, Volume 41, Issue 6Author(s): Ozkan Isik, Ilkay DoganAbstractBackgroundIt is known that different intensity exercises create skeletal muscle damage at different levels. The purpose of the study was to compare effects of bilateral or unilateral lower body resistance exercise on markers of skeletal muscle damage.MethodsThe Brzycki Formula was used to calculate participants' one repetition maximum strength for each movement and limb, separately. Blood samples were obtained before exercise, immediately after exercise, and 30 min after exercise for both types of exercise. Creatine Kinase (CK), Lactate Dehydrogenase (LDH), Aspartate Aminotransferase (AST), and Alanine Aminotransferase (ALT) levels were analyzed. Data was analyzed using two-way repeated measures ANOVA.ResultsWhen CK, AST, and ALT levels were compared according to time points, a statistical difference was found (p 
  • Subjective and objective assessments of sleep problems in children with
           attention deficit/hyperactivity disorder and the effects of
           methylphenidate treatment

    • Abstract: Publication date: December 2018Source: Biomedical Journal, Volume 41, Issue 6Author(s): Wei-Chih Chin, Yu-Shu Huang, Ya-Hsin Chou, Chih-Huan Wang, Kuang-Tai Chen, Jen Fu Hsu, Shih-Chieh HsuAbstractBackgroundto investigate the sleep problems in children with different ADHD presentations and effects of methylphenidate (MPH) on the sleep problems of children with ADHD by both subjective and objective measurements.Methods71 children with ADHD and 30 controls were included. 35 had ADHD with predominantly inattentive presentation (ADHD-I) and 36 with predominantly hyperactive/impulsive or combined presentation (ADHD-C). We used the pediatric sleep questionnaire (PSQ) and a nocturnal polysomnography (PSG) to assess the sleep problems in children with ADHD before and 6 months after being treated with methylphenidate (0.3–0.7 mg/kg/dose).ResultsPSG showed significantly higher apnea-hypopnea index and hypopnea counts, and lower slow-wave sleep percentage in children with ADHD. The results of PSQ reported by parents showed significantly higher rates of delay initiation of sleep, sleep onset latency, sleep fragment, daytime sleepiness, enuresis, bruxism, nightmares, periodic limb movement disorder (PLMD), and snoring in children with ADHD compared to normal controls. Comparisons of ADHD presentations revealed no significant difference between ADHD-I and ADHD-C by either PSG or PSQ measurements. After 6-month MPH treatment, the PSG showed significantly increased total sleep time and reduced periodic limb movement index (PLMI). The PSQ indicated significant reduction in bruxism and snoring in ADHD-I, as well as nightmares in ADHD-C, and both subgroups showed significant reduction in PLMD.Conclusionsubjective and objective approaches produced inconsistent findings regarding the sleep problems in children with ADHD. Besides, MPH didn't worsen the sleep problems in children with ADHD.
  • Dengue outbreaks and the geographic distribution of dengue vectors in
           Taiwan: A 20-year epidemiological analysis

    • Abstract: Publication date: October 2018Source: Biomedical Journal, Volume 41, Issue 5Author(s): Wei-June ChenAbstractDengue fever is an important mosquito-borne viral infectious disease that mostly occurs in tropical and subtropical areas of the world. According to epidemiological data from the Center for Disease Control of Taiwan, more than 98.62% of outbreaks of indigenous total dengue cases were reported in the southern part of Taiwan. Southern Taiwan is an aggregate area encompassing Tainan, Kaohsiung, and Pingtung, all of which are located below the Tropic of Cancer (23º35′N). With a few exceptions, dengue outbreaks mainly occur in southern Taiwan which is highly associated or overlaps with the prevalence of Aedes aegypti. A.aegypti is presumed to be absent from the northern part of Taiwan, while Aedes albopictus breeds in areas throughout the island. According a collection of 20 years of epidemiological data from Taiwan, the inability of A. aegypti to survive the winter weather in northern Taiwan may account for its restricted geographical distribution and that of dengue outbreaks it transmits. A.aegypti, unlike temperate strains of A. albopictus, lacks embryonic diapause signaled by a short photoperiod which thus reduces its cold-hardiness. Therefore it is intolerant of low temperatures that frequently accompany rains and unable to survive during winter in the northern part of Taiwan.
  • Dengue in Taiwan: Pointing the finger at Aedes aegypti

    • Abstract: Publication date: October 2018Source: Biomedical Journal, Volume 41, Issue 5Author(s): Emma Louise WaltonAbstractIn this issue of the Biomedical Journal we explore the history of dengue infection in Taiwan and what current trends have to say about the vector responsible for transmitting the disease on the island. We focus on original research reporting the development of a new perfusion bioreactor to engineer bone from human cord blood stem cells. Finally, we look at trends in osteoporosis in Taiwan and how they highlight the success of public health campaigns.
  • Improved osteogenic differentiation of umbilical cord blood MSCs using
           custom made perfusion bioreactor

    • Abstract: Publication date: October 2018Source: Biomedical Journal, Volume 41, Issue 5Author(s): Bhaskar Birru, Naveen Kumar Mekala, Sreenivasa Rao ParchaAbstractBackground3D cell culture is an appropriate method to develop engineered bone tissue, where different bioreactors have been designed to mitigate the challenges in 3D culture. Currently, we tailored a perfusion reactor to witness human mesenchymal stem cells (MSCs) proliferation and differentiation over polylactic acid-polyethylene glycol (PLA/PEG) composite scaffolds.MethodsThe composite scaffolds with different weight ratios of PLA and PEG were prepared using solvent casting-particulate leaching technique. Human umbilcal card blood MSCs were cultured under dynamic and static conditions to elucidate the role of dynamic fluid flow in osteogenesis of MSCs.ResultsThe human MSCs distribution over the scaffolds was confirmed with fluorescent microscopy. Alkaline phosphatase (ALP), calcium mineralization, and collagen formation were found to be higher in PLA90 scaffolds than PLA100 and PLA75. PLA90 scaffolds with better cell adhesion/proliferartion were considered for bioreactor studies and they exhibited enhanced ALP, Ca+2 mineralization and collagen formation under dynamic perfusion than static culture. We further confirmed our observation by looking at expression levels of osteogenic marker (Runx2 and osteonectin) in differentiated MSCs subjected to perfusion culture compared to static culture.ConclusionThe results of the current investigation once again proves that dynamic perfusion cultures improve the osteogenic differentiation of MSCs over hybrid polymer scaffolds (PLA90) for effective bone regeneration.
  • Depressant effect of geraniol on the central nervous system of rats:
           Behavior and ECoG power spectra

    • Abstract: Publication date: October 2018Source: Biomedical Journal, Volume 41, Issue 5Author(s): Katty Anne A.L. Medeiros, José R. dos Santos, Thaís Cristina de S. Melo, Marina F. de Souza, Luciano de G. Santos, Auderlan M. de Gois, Rachel R. Cintra, Lívia Cristina R.F. Lins, Alessandra M. Ribeiro, Murilo MarchioroAbstractGeraniol is a monoterpene alcohol that is derived from the essential oils of aromatic plants, with anti-inflammatory, antimicrobial, antioxidant and neuroprotective properties. This study characterized the effect of geraniol on behavior and brainwave patterns in rats. Male rats were submitted to administration of geraniol (25, 50 and 100 mg/kg). The hole board (HB) and open field (OF) tests were performed to evaluate anxiety and motor behavior, respectively. In addition, barbiturate-induced sleeping time (BIST) was used to analyze sedative effect. Finally, electrocorticogram (ECoG) recordings were used to characterize brain-wave patterns. The results showed that geraniol treatment in rats decreased the distance traveled, rearing numbers and lead to increase in immobility time in HB and OF tests. In BIST test, geraniol treatment increased sleep duration but not sleep latency in the animals. Furthermore, geraniol-treated animals demonstrated an increase in the percentage of delta waves in the total spectrum power. Taken together, our results suggested that geraniol exerted a depressant effect on the central nervous system of rats.
  • The streptozotocin-high fat diet induced diabetic mouse model exhibits
           severe skin damage and alterations in local lipid mediators

    • Abstract: Publication date: October 2018Source: Biomedical Journal, Volume 41, Issue 5Author(s): Alberto Leguina-Ruzzi, Rina Ortiz, Victoria VelardeAbstractBackgroundType 2 diabetes (T2D) can go undiagnosed for years, leading to a stage where produces complications such as delayed skin wound healing. Animal models have been developed in the last decades to study the pathological progression in this disease. Streptozotocin (STZ), that has a selective pharmacological toxicity toward pancreatic β cells, in addition to high fat diet has been widely used to induce diabetes however no evidence has shown its effects on the skin integrity.MethodsEighteen C57BL/6J male mice, were divided in 3 groups; the first was fed with chow diet and the second was kept on a high fat diet and the third injected with STZ intraperitoneal for 5 days consecutively before starting the diet protocol with high fat. Mice were maintained 5 weeks in total.ResultsWe show that animals treated with STZ-high fat diet exhibit skin injuries without significant alterations on basal insulin and triglycerides, compared to the control. The skin from these animals presents higher levels of oxidative stress, lower levels of adhesion proteins and alterations in lipid mediators, effects that are not produced by the high fat diet itself.ConclusionOur results suggest that this in vivo model represents a relevant approach for studying skin damage induced by diabetes.
  • Size scaling of nucleolus in Caenorhabditis elegans embryos

    • Abstract: Publication date: October 2018Source: Biomedical Journal, Volume 41, Issue 5Author(s): Tian-Hsiang Ma, Po-Hsiang Chen, Bertrand Chin-Ming Tan, Szecheng J. LoAbstractNucleolus is viewed as a plurifunctional center in the cell, tightly linked to ribosome biosynthesis. As a non-membranous structure, how the size of nucleolus is determined is a long outstanding question, and the possibility of “direct size scaling to the nucleus” was raised by genetic studies in fission yeast. Here, we used the model organism Caenorhabditis elegans to test this hypothesis in multi-cellular organisms. We depleted ani-2, ima-3, or C27D9.1 by RNAi feeding, which altered embryo sizes to different extents in ncl-1 mutant worms. DIC imaging provided evidence that in size-altering embryo nucleolar size decreases in small cells and increases in large cells. Furthermore, analyses of nucleolar size in four blastomeres (ABa, ABp, EMS, and P2) within the same embryo of ncl-1 mutants consistently demonstrated the correspondence between cell and nucleolar sizes – the small cells (EMS and P2) have smaller nucleoli in comparison to the large cells (ABa).
  • Secular trends in incidence of osteoporosis in Taiwan: A nationwide
           population-based study

    • Abstract: Publication date: October 2018Source: Biomedical Journal, Volume 41, Issue 5Author(s): Fang-Ping Chen, Ting-Shuo Huang, Tsai-Sheng Fu, Chi-Chin Sun, An-Shine Chao, Tien-Ling TsaiAbstractBackgroundThe present study aimed to assess the changes in trend of osteoporosis among the Taiwanese population from 2001 to 2011.MethodsThe National Health Insurance Research Database (NHIRD) of Taiwan, containing records from approximately 23 million insures from 2001 to 2011, was analyzed. Insurees aged≧50 years with osteoporosis were identified either from previously documented osteoporotic diagnosis or osteoporosis-related fractures according to Clinical Modification (ICD-9-CM) diagnostic code.ResultsThe prevalence of osteoporosis increased from 17.4% in 2001 to 25.0% in 2011. The prevalence trend increased from 2001 to 2005 and plateaued thereafter. During 2001–2005, the incidence rate of hip fracture held steady from 277 to 281 per 100,000 person-years, and decreased thereafter from 262 to 247 per 100,000 person-years. The overall incidence of osteoporosis declined among patients younger than 84 years from 2001 to 2011, especially after 2005. As compared with 2005 and before, the incidence rate of osteoporosis was significantly decreased since 2006.ConclusionsThe secular changes of osteoporosis in Taiwan are quite similar to the trend in western countries. It reveals how osteoporosis awareness and policy interventions can affect the prevalence trend of osteoporosis.
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Heriot-Watt University
Edinburgh, EH14 4AS, UK
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