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Showing 1 - 200 of 3562 Journals sorted alphabetically
16 de Abril     Open Access  
AADE in Practice     Hybrid Journal   (Followers: 4)
ABCS Health Sciences     Open Access   (Followers: 1)
Abia State University Medical Students' Association Journal     Full-text available via subscription  
ACIMED     Open Access   (Followers: 1)
ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 39)
Acta Bio Medica     Full-text available via subscription   (Followers: 2)
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Acta Bioquimica Clinica Latinoamericana     Open Access   (Followers: 1)
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Acta Informatica Medica     Open Access   (Followers: 1)
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Acta Medica Peruana     Open Access   (Followers: 2)
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Acta Scientiarum. Health Sciences     Open Access  
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 2)
Addiction Science & Clinical Practice     Open Access   (Followers: 7)
Addictive Behaviors Reports     Open Access   (Followers: 6)
Advanced Health Care Technologies     Open Access   (Followers: 4)
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Advances in Wound Care     Hybrid Journal   (Followers: 10)
African Health Sciences     Open Access   (Followers: 2)
African Journal of Biomedical Research     Open Access  
African Journal of Clinical and Experimental Microbiology     Open Access   (Followers: 1)
African Journal of Laboratory Medicine     Open Access   (Followers: 2)
African Journal of Medical and Health Sciences     Open Access   (Followers: 2)
African Journal of Trauma     Open Access  
Afrimedic Journal     Open Access   (Followers: 2)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 8)
AJOB Primary Research     Partially Free   (Followers: 3)
Aktuelle Ernährungsmedizin     Hybrid Journal   (Followers: 4)
Al-Azhar Assiut Medical Journal     Open Access  
Alexandria Journal of Medicine     Open Access   (Followers: 1)
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 2)
Alpha Omegan     Full-text available via subscription  
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 3)
American Journal of Biomedical Engineering     Open Access   (Followers: 11)
American Journal of Biomedical Research     Open Access   (Followers: 2)
American Journal of Biomedicine     Full-text available via subscription   (Followers: 6)
American Journal of Chinese Medicine, The     Hybrid Journal   (Followers: 5)
American Journal of Clinical Medicine Research     Open Access   (Followers: 5)
American Journal of Family Therapy     Hybrid Journal   (Followers: 11)
American Journal of Law & Medicine     Full-text available via subscription   (Followers: 12)
American Journal of Lifestyle Medicine     Hybrid Journal   (Followers: 5)
American Journal of Managed Care     Full-text available via subscription   (Followers: 11)
American Journal of Medical Case Reports     Open Access   (Followers: 1)
American Journal of Medical Sciences and Medicine     Open Access   (Followers: 1)
American Journal of Medicine     Hybrid Journal   (Followers: 46)
American Journal of Medicine and Medical Sciences     Open Access   (Followers: 1)
American Journal of Medicine Studies     Open Access  
American Journal of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American Journal of the Medical Sciences     Hybrid Journal   (Followers: 12)
American Journal on Addictions     Hybrid Journal   (Followers: 9)
American Medical Journal     Open Access   (Followers: 4)
American medical news     Free   (Followers: 3)
American Medical Writers Association Journal     Full-text available via subscription   (Followers: 2)
Amyloid: The Journal of Protein Folding Disorders     Hybrid Journal   (Followers: 4)
Anales de la Facultad de Medicina     Open Access  
Anales de la Facultad de Medicina, Universidad de la República, Uruguay     Open Access  
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1)
Analgesia & Resuscitation : Current Research     Hybrid Journal   (Followers: 3)
Anatomical Science International     Hybrid Journal   (Followers: 2)
Anatomical Sciences Education     Hybrid Journal   (Followers: 1)
Anatomy Research International     Open Access   (Followers: 2)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3)
Annales de Pathologie     Full-text available via subscription  
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 3)
Annals of African Medicine     Open Access   (Followers: 1)
Annals of Anatomy - Anatomischer Anzeiger     Hybrid Journal   (Followers: 2)
Annals of Bioanthropology     Open Access   (Followers: 3)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18)
Annals of Biomedical Sciences     Full-text available via subscription   (Followers: 3)
Annals of Clinical Microbiology and Antimicrobials     Open Access   (Followers: 8)
Annals of Family Medicine     Open Access   (Followers: 13)
Annals of Fundeni Hospital     Open Access   (Followers: 1)
Annals of Ibadan Postgraduate Medicine     Open Access  
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Medicine     Hybrid Journal   (Followers: 12)
Annals of Medicine and Surgery     Open Access   (Followers: 5)
Annals of Microbiology     Hybrid Journal   (Followers: 10)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Saudi Medicine     Open Access  
Annals of the New York Academy of Sciences     Hybrid Journal   (Followers: 5)
Annals of The Royal College of Surgeons of England     Full-text available via subscription   (Followers: 3)
Annual Reports in Medicinal Chemistry     Full-text available via subscription   (Followers: 7)
Annual Reports on NMR Spectroscopy     Full-text available via subscription   (Followers: 4)
Annual Review of Medicine     Full-text available via subscription   (Followers: 18)
Anthropological Review     Open Access   (Followers: 24)
Anthropologie et santé     Open Access   (Followers: 5)
Antibiotics     Open Access   (Followers: 9)
Antibodies     Open Access   (Followers: 2)
Antibody Technology Journal     Open Access   (Followers: 1)
Anuradhapura Medical Journal     Open Access  
Anwer Khan Modern Medical College Journal     Open Access   (Followers: 2)
Apmis     Hybrid Journal   (Followers: 1)
Apparence(s)     Open Access   (Followers: 1)
Applied Clinical Informatics     Hybrid Journal   (Followers: 2)
Applied Medical Informatics     Open Access   (Followers: 11)
Arab Journal of Nephrology and Transplantation     Open Access   (Followers: 1)
Arak Medical University Journal     Open Access  
Archive of Clinical Medicine     Open Access   (Followers: 1)
Archive of Community Health     Open Access  
Archives of Biomedical Sciences     Open Access   (Followers: 7)
Archives of Medical and Biomedical Research     Open Access   (Followers: 3)
Archives of Medical Laboratory Sciences     Open Access   (Followers: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Trauma Research     Open Access   (Followers: 2)
Archivos de Medicina (Manizales)     Open Access  
ArgoSpine News & Journal     Hybrid Journal  
Arquivos Brasileiros de Oftalmologia     Open Access  
Arquivos de Ciências da Saúde     Open Access  
Arquivos de Medicina     Open Access  
ARS Medica Tomitana     Open Access   (Followers: 1)
Art Therapy: Journal of the American Art Therapy Association     Full-text available via subscription   (Followers: 10)
Arterial Hypertension     Open Access  
Artificial Intelligence in Medicine     Hybrid Journal   (Followers: 12)
Artificial Organs     Hybrid Journal   (Followers: 1)
Asia Pacific Family Medicine     Open Access  
Asia Pacific Journal of Clinical Nutrition     Full-text available via subscription   (Followers: 9)
Asia Pacific Journal of Clinical Trials : Nervous System Diseases     Open Access  
Asian Bioethics Review     Full-text available via subscription   (Followers: 2)
Asian Journal of Cell Biology     Open Access   (Followers: 6)
Asian Journal of Health     Open Access   (Followers: 3)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 2)
Asian Journal of Medical and Pharmaceutical Researches     Open Access   (Followers: 1)
Asian Journal of Medical Sciences     Open Access   (Followers: 1)
Asian Journal of Scientific Research     Open Access   (Followers: 2)
Asian Journal of Transfusion Science     Open Access   (Followers: 2)
Asian Medicine     Hybrid Journal   (Followers: 4)
ASPIRATOR : Journal of Vector-borne Disease Studies     Open Access  
Astrocyte     Open Access  
Atención Familiar     Open Access  
Atención Primaria     Open Access   (Followers: 1)
Audiology - Communication Research     Open Access   (Followers: 8)
Auris Nasus Larynx     Full-text available via subscription  
Australian Coeliac     Full-text available via subscription   (Followers: 2)
Australian Family Physician     Full-text available via subscription   (Followers: 3)
Australian Journal of Medical Science     Full-text available via subscription   (Followers: 1)
Autopsy and Case Reports     Open Access  
Aviation, Space, and Environmental Medicine     Full-text available via subscription   (Followers: 10)
Avicenna     Open Access   (Followers: 2)
Avicenna Journal of Medicine     Open Access   (Followers: 1)
Bangabandhu Sheikh Mujib Medical University Journal     Open Access   (Followers: 1)
Bangladesh Journal of Anatomy     Open Access   (Followers: 1)
Bangladesh Journal of Bioethics     Open Access  
Bangladesh Journal of Medical Biochemistry     Open Access   (Followers: 3)
Bangladesh Journal of Medical Education     Open Access   (Followers: 2)
Bangladesh Journal of Medical Microbiology     Open Access   (Followers: 3)
Bangladesh Journal of Medical Physics     Open Access  
Bangladesh Journal of Medical Science     Open Access  
Bangladesh Journal of Medicine     Open Access   (Followers: 1)
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Bangladesh Journal of Scientific Research     Open Access   (Followers: 2)
Bangladesh Medical Journal     Open Access  
Bangladesh Medical Journal Khulna     Open Access  
Bangladesh Medical Research Council Bulletin     Open Access  
Basal Ganglia     Hybrid Journal  
Basic Sciences of Medicine     Open Access   (Followers: 2)
BBA Clinical     Open Access  
BC Medical Journal     Free  
Benha Medical Journal     Open Access  
Bijblijven     Hybrid Journal  
Bijzijn     Hybrid Journal   (Followers: 2)
Bijzijn XL     Hybrid Journal   (Followers: 1)
Bio-Algorithms and Med-Systems     Hybrid Journal   (Followers: 1)
BioDiscovery     Open Access   (Followers: 2)
Bioelectromagnetics     Hybrid Journal   (Followers: 1)
Bioengineering & Translational Medicine     Open Access  
Bioethics     Hybrid Journal   (Followers: 14)
Bioethics Research Notes     Full-text available via subscription   (Followers: 14)
Biologics in Therapy     Open Access  
Biology of Sex Differences     Open Access   (Followers: 3)

        1 2 3 4 5 6 7 8 | Last

Journal Cover American Journal of Medicine and Medical Sciences
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  This is an Open Access Journal Open Access journal
   ISSN (Print) 2165-901X - ISSN (Online) 2165-9036
   Published by SAP Homepage  [105 journals]
  • A Study on Age at Menarche of School Going Girls in Bangladesh

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Akifa Akther,Rafiqul IslamThe aim of this research is to study age at menarche of school going girls in . For this purpose, the data is acquired from of the classes of five, six, seven and eight during1st June. In this study, it is to investigate the pattern of age at menarche of total respondents and the pattern of height, weight and body mass index by the age of the respondents in accordance with menarche and non-menarche. The age range of the respondents was between 10 to 14 years. Chi-square test and logistic regression analysis are employed in this paper. This study also displays the association of age at menarche with socio-demographic variables of respondents. It is realized from the association that early menarche for school going girl’s height, weight, father income, body mass index, time spent by watching television and father educational qualification were highly significant but mother educational qualification, mother occupation, father occupation, number of siblings, order of birth, time spent by playing and mother time spent were insignificant. In logistic analysis, it was found that only height, weight and time spent by watching TV were significant which have positive effects on age at menarche.
      PubDate: 10/17/2012 17:17:43
  • Level of Awareness of Hpv Involvement in Prostatic Cancer Among Different
           Cadres of Medical Doctors

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Ajobiewe Olu Joseph,Isu Nnena Rosemary,Agwale Simon,Ajobiewe H.F,Dangana AClinicians most times pay less attention to the relevance of HPV in prostatitis either deliberately or ignorantly; hence , this study intends to unravel this sort of attitude through interrogation of the different cadres of doctors. Informed consent research questionnaires were administered to the various cadres of medical doctors at the various locations earmarked for this study -using the Stratified sampling technique . Some questions were deliberately ignored in order to concentrate on the level of awareness of HPV involvement in prostatitis among the various cadres of Medical Doctors. Results showed that the level of awareness among these cadres of doctors were significantly very low (P
      PubDate: 10/17/2012 17:17:43
  • Distance Mesuring of Physical Activity among Students and Workers of
           Moscow State University of Medicine and Dentistry

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Konstantin G. Gurevich,Pavel L. Salmanov,Dmitrii A. PustovalovSince 2007 Moscow State University of Medicine and Dentistry (MSUMD) uses its own teleconferencing facilities. Distance learning courses on health promotion were started. Electronic textbooks in the field of health promotion were made available. Online questionnaire was design to determine physical activity (PA) which is known to be one of risk factors of development of chronic disease. Methods: 846 students and 144 workers of MSUMD were distance tested to detect their usual PA. Results: The used procedure proved to be valid. PA in women demonstrated to be lower than in men; PA of workers was higher than in students. Additional risk factors (i.e. obesity, smoking) were earlier found in students. Conclusion: Female students might have higher risk of noncommunicable diseases than male students in future due to their low PA. It seems to be higher spread of behavior risk factors among students than workers.
      PubDate: 10/17/2012 17:17:43
  • Adolescent Cannabis Use - a Young Adult and Middle Age Urologic and
           Reproductive Dilemma: The Niger Delta Malady

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  H A A Ugboma,H L Aburoma,P UkaigweThe sudden affluence in the Niger delta area of Nigeria due to the oil and gas industry, brought with it certain vices like the increasing use of Cannabis (Marijuana) by its younger population. This exposure to Cannabis has increased the incidence in urological and reproductive pathologies. Frequent marijuana use significantly increase testicular cancer risk and several urologic dysfunctions. This study clinically investigates the epidemiological evidence on the major adverse health effects of cannabis use and the link associated with urological dysfunctions and considers its implications for policy. A cross-sectional sample of 2290 males attending urology primary care clinics and inpatients in healthcare institutions in the Niger Delta Region was undertaken, 75 of the cases were included in the randomized follow-up study from March 2009 to March 2011. Those who use marijuana weekly or who have had exposure to marijuana since adolescents had twice the cancer risk, erectile and infertile anomalies, when compared to men who never smoked marijuana. Cannabis use was associated with urological dysfunctions like erectile dysfunctions, infertility and testicular cancer.
      PubDate: 10/17/2012 17:17:43
  • Chronic Simvastatin Treatments Attenuate Ethanol Withdrawal Syndrome in

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  M. M. S. Carrocini,A. L. R. L. Caxambú,N. S. Kelle,D. D. Lima,J. N. Cruz,D. D. Dal Magro,J. G. P. Cruz Rodent models of ethanol withdrawal-induced anxiety have been used to explore the neurobiology underlying withdrawal and to evaluate the utility of therapeutic agents aimed at reducing withdrawal severity. Of the many tests of anxiety-like behavior, the elevated plus maze and open field are the most commonly used. In general, ethanol withdrawal decreases most or all of the individual behaviors recorded in these tasks, indicating the occurrence of an anxiogenic-like effect of withdrawal in rodents. Effects of sub-chronic simvastatin treatments on ethanol withdrawal syndrome were investigated in rats. Ethanol (7.2% v/v) was given to adult male Wistar rats by a liquid diet for 30 days. Sub-chronic (once daily) simvastatin (1 or 10 mg/kg) or saline were administered to rats by oral gavage. After 24 hours of ethanol withdrawal on the simvastatin treatment rats were observed in behavior tests. The increases the time open arms entries in the elevated plus-maze and grooming in the open-field through the exposure to sub-chronic treatment with simvastatin in rats submitted to ethanol intake, indicating beneficial effects on ethanol withdrawal syndrome. Our results suggest that sub-chronic simvastatin treatment attenuates ethanol withdrawal syndrome in ethanol-dependent rats and this drug may be useful for treatment of ethanol-type dependence.
      PubDate: 10/17/2012 17:17:43
  • Co-Morbid Factors Related to Surgical Complications in Kidney Transplant

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Maroun M. Abou-Jaoude,Haidar Nasser,Alain N. Khalaf,Walid J. Abou-Jaoude,Ziad DaoudWe have studied retrospectively the demographics and different post transplantation morbidities associated with surgical complications in 200 kidney transplant recipients between May 1997 and January 2008. Patients were divided into 2 groups: Group I including 177 patients without surgical complications and Group II including 23 patients who had surgical complications. Baseline demographics and later co-morbidities were analyzed. The baseline characteristics between the 2 groups did not differ significantly, including donor and recipient age and sex, recipient’s body mass index, cause of original renal disease, transplantation date, dialysis duration, recipient’s degree of sensitization and pre-transplantation diabetes. However significant difference between the 2 groups included: pre and post-transplant hemoglobin blood level differences (2.6 ± 1.8 mg/dl in Group I versus 4.1 ± 2.0 mg/dl in Group II), number of post-transplant transfusions (0.4 ± 0.8 in Group I versus 2.2 ± 3.7 in Group II), duration of hospital stay (10.9 ± 4.3 days in Group I, versus 17.5 ± 9.2 days in Group II), mean serum creatinine upon discharge (1.47 ± 0.84 mg/dl in Group I versus 2.7 ± 2.87 mg/dl in Group II), death and graft failure at 6 months post-transplant (2 in Group I versus 2 in Group II and 3 in Group I versus 5 in Group II respectively). We conclude that surgical complications were associated with significant short and long term co-morbidities, including duration of hospital stay, serum creatinine upon discharge, and death and graft failures at 6 months post-transplantation.
      PubDate: 10/17/2012 17:17:43
  • Toxicity Effects of Amlodipine on the Testis Histology in Adult Wistar

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Adefule Adebayo,Adesanya Olamide,Akpan Helen,Huthman Ibrahim Oluwaseun,Soyebo Olusegun,Huthman Adebukola SelimotAmlodipine is one of the calcium channel blocker class of antihypertensives used in the treatment of hypertension. This study was carried out to appraise the toxicity effects of Amlodipine on the testis histology in Adult Wistar rats based on the fact that amilodipine is usually consumed by the elderly who have a slow metabolic rate hence leading to accumulation of the drug in their system causing toxicity. The rats were divided into 3 groups: one group one was given normal saline while group 2 and 3 were administered with 0.052mg/g/BW and 0.104mg/g/BW of amlodipine respectively for 5 weeks. Our preliminary observations showed that administration of Amlodipine lead to an abnormal morphology of the testis in that, it had a deleterious effect on the seminiferous tubules in a dose related fashion.By these preliminary observations, alteration in the testis histology may have implication for infertility in man.
      PubDate: 10/17/2012 17:17:43
  • Effect of Ondansetron alone or in Combination with Dehydrobenzperidole and
           Dexamethasone on Discharge Time Following Gynecological Laparoscopy

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Hanne Ulka Petersen,Claus HemmingsenWe aimed to examine a possible accelerated discharge time after gynecological laparoscopy when treated with a combination of ondansetron, dehydrobenzperidole and dexamethasone as compared to ondansetron alone. Sixty ASA 1-2 women were included in this prospective double-blind study and were randomised to either peroperative ondansetron 4 mg, dehydrobenzperidole 0.625 mg and dexamethasone 8 mg or to ondansetron 4 mg only. General anaesthesia was induced by fentanyl, propofol, mivacurium and maintained by sevoflurane in 50% oxygen. Patients were tracheal intubated and had a orogastric tube during the laparoscopy. The neuromuscular block was allowed to wear of without the use of neostigmine. In case of postoperative nausea and vomiting in the ondansetron only group, escape medication with dehydrobenzperidole and dexamethasone was given. The discharge criteria at the day surgery unit were fulfilled at 7h 45min (range 3h 10min - 24h 16min) after the end of surgery in the women treated with ondansetron only, but was accelerated to 5h 11min (range 3h 9min – 21h 8min) in the women having peroperative treatment with both ondansetron, dehydrobenzperidole and dexamethasone (p
      PubDate: 10/17/2012 17:17:43
  • Oral Administration of Aqueous Leaf Extract of Ocimum Gratissimum
           Ameliorates Polyphagia, Polydipsia and Weight Loss in
           Streptozotocin-Induced Diabetic Rats

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  OKON U. A.,Owo D.U.,Udokang N.E.,Udobang J.A.,Ekpenyong C.E.The effects of oral administration of aqueous leaf extract of Ocimum gratissimum (OG) on food, water intake and weight changes in streptozotocin (STZ)-induced diabetic Albino Wistar rats was studied. Eighteen rats were randomly assigned into 3 groups of 6 rats each for control, diabetic (DM) and diabetic-treated (DMT) groups. Diabetes mellitus was induced in the test groups (DM and DMT) by a single dose of STZ (65 mg/kg, i.p.). The extract was administered per oral to the DMT group at a dose of 1500 mg/k body weight daily for 28 days. All the groups were fed normal rat chow and allowed water freely. The fasting blood glucose levels in the DM and DMT groups were higher (P
      PubDate: 10/17/2012 17:17:43
  • Alleviating Effect of Phyllanthus niruri on Sensorimotor and Cognitive
           Changes Induced by Subacute Chlorpyrifos Exposure in Wistar Rats

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Suleiman F. Ambali,Annas O. Makinde,Muftau Shittu,Stephen A. Adeniyi,Favour O. Mowuogwu Objective: Studies in animal models and humans have shown that chlorpyrifos (CPF) causes sensorimotor and cognitive changes. Apart from inhibiting acetylcholinesterase (AChE), the induction of oxidative stress is one of the other molecular mechanisms implicated in OP-evoked toxicity. The present study evaluated the alleviating effect of Phyllanthus niruri, a flavonoid rich plant, on subacute CPF-evoked sensorimotor and cognitive changes in Wistar rats. Design: Thirty five adult male Wistar rats divided into five groups of seven rats were used for the study. Groups 1 and II were given soya oil (2 ml/kg) and CPF (10.6 mg/kg~1/8th of LD50), respectively. Group III was administered methanol extract of Phyllanthus niruri (MEP) at 500 mg/kg only. Group IV was administered MEP (250 mg/kg) and CPF (10.6 mg/kg), 30 min later while group V was administered with MEP (500 mg/kg) and CPF (10.6 mg/kg), 30 min later. The regimens were administered by gavage once daily for 28 days during which periodic evaluation of sensorimotor and cognitive performances were carried out. Thereafter, the brain was evaluated for AChE activity and malonaldehyde (MDA) concentration. Results: CPF caused deficits in sensorimotor reflexes and cognition, increased brain MDA concentration and decreased AChE activity, which were all mitigated by MEPN. Conclusion: The study concludes that mitigation of sensorimotor and cognitive deficits elicited by CPF was mitigated by MEP partly due to the antilipoperoxidative and acetylcholinesterase restoration properties of its flavonoid constituent.
      PubDate: 10/17/2012 17:17:43
  • Dextrocardia With Situs Inversus Totalis in an Adult Nigerian: a Case

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Uchenna DI,Jesuorobo DE,Anyalechi JISitus inversus with dextrocardia is the complete inversion of position of the thoracic and abdominal viscera. It may be isolated or associated with malformations, especially cardiac or alimentary. It may be discovered in infancy because of associated anomalies but often remains asymptomatic and discovered by chance in adult life. We report a 69 year old Nigerian woman found to have dextrocardia with situs inversus totalis while presenting for treatment for a totally unrelated problem. Her chest radiograph was however erroneously marked by the radiographer as normal resulting in a wrong report. The findings from an electrocardiogram and echocardiography confirmed the location of the heart in the right hemithorax and an abdominal sonogram showed the liver and gall bladder on the left side of the abdomen while the stomach and spleen were located on the right side. This report underscores the need for routine screening by individuals so that such congenital anomalies can be identified and surgical diagnoses in such patients made correctly to prevent surgical complications.
      PubDate: 10/17/2012 17:17:43
  • Formulation and Optimization of Drug-Resin Complex Loaded Mucoadhesive
           Chitosan Beads of Repaglinide Using Factorial Design

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Ashwini R. M.,Mangesh R. B.,Rahul R. P.,Nilkanth S. P.,Devaki C. U.Some ion exchange resins like Cholestyramine (Duolite AP-143), provide extended gastric retention and have the ability to coat the gastric mucosa uniformly. The use of such mucoadhesive ion exchange resins is another attractive approach in the development of targeted formulations for the GIT. In pesent work, a mucoadhesive gastroretentive system for Repaglinide was developed and optimized using Duolite AP-143 resin by RSM. Studies were carried out to develop and optimize oral mucoadhesive beads for Repaglinide using ion exchange resin and chitosan. Resinates prepared were studied for the effect of pH and drug resin ratio on drug loading. Resin and resinates were evaluated for mucoadhesive property using falling liquid film method. Resin and resinates showed sufficient mucoadhesion strength when compared with other mucoadhesive polymers and other ion exchange resins. Dissolution study of Repaglinide resinate showed that Duolite AP-143 was able to sustain the release of drug. The study suggests that the mucoadhesive beads of Repaglinide provide sustained release over 8 h and also shows sufficient mucoadhesive strength with rabbit gastric mucosa.
      PubDate: 10/17/2012 17:17:43
  • Effects of a Single Pill 3-drug Combination of Lamivudine, Nevirapine and
           Zidovudine on Blood Parameters and Liver Histology in Female Wistar Rats

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Adesanya Olamide Adewale,Otulana Olatoye Jubril,Huthman Ibrahim Oluwaseun,Huthman Adebukola Selimot,Adesanya Rotimi AyoolaDue to the stigma associated with HIV infection, HIV infected persons in Nigeria, have been found to remove the packs of their drugs and transferring the contents into non antiretroviral drug containers especially multivitamin containers, as a result unwary individuals have stumbled on such drugs and accidentally consumed it eventually leading to a host of complains such as dizziness, vague dreams, cramps etc. We therefore decided to study the effects of a single pill 3-drug combination of Lamivudine, Nevirapine and Zidovudine on the liver histology and blood parameters in the adult female rats. The rats were divided into two groups of 5 animals per group: one group received drug at a dose of 1.85mg/100g BW dissolved in normal saline while the control group received normal saline 0.5ml/100g BW for three weeks. From our observation we discovered that there was an aberration in liver histology of the experimental group in that the central vein was dilated as compared to the control group and also discovered that the drug had some effect on the blood parameters, which include among other things a significant decrease in PCV and a significant increase in WBC. The enlargement of the central vein of the liver observed in this study may be due to the presence of Nevirapine in the drug regimen and this may be of serious implication on liver function.
      PubDate: 10/17/2012 17:17:43
  • Correlation Between Koilocytes, HPV DNA and CD4 Cells Count in Male
           and Female HIV Cohorts

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Ajobiewe Olu Joseph,Isu Nnena Rosemary,Agwale SimonThe study x-rays the relationship between Koilocytes and [Cluster of Differentiation]CD4 Count from HIV positive unisex cohorts aged 15 -40 years and above. The cohorts, were randomly tested for the presence of koilocytes, using their semen and endocervical swab samples respectively at some top Hospitals in Abuja, F.C.T. Nigeria. Their blood samples were tested for CD4 count. Papanicolaou staining technique was adopted-for demonstrating koilocytes. Results showed that, high koilocytes count of 39.0% and low CD4 Count of 350 lymphocyte counts /µl were observed; and low monthly mean koilocytes count of 7.60% and high CD4 Count of 687 lymphocytes counts/ µl were observed in the female and male cohorts respectively. High monthly prevalence count of koilocytes and low CD4 Count in the female cohorts and verse versa in the male cohorts were significantly correlated (P
      PubDate: 10/17/2012 17:17:43
  • A Multi-scale Bayesian Hypothesis Testing Approach for the Analysis of
           Prepulse Inhibition Test

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Hong bo Zhou,Qiang Cheng,Hong -Ju Yang,Hai yun XuPrepulse inhibition (PPI) deficits have been seen in various neuropsychiatric disorders, such as schizophrenia, Tourette’s syndrome and Huntington’s disease. How to effectively distinct these PPI deficit subjects from normal ones is a challenging task because the PPI data measured from animal experiments are usually erroneous, incomplete, and unstable. In this paper, we introduce a novel multi-scale Bayesian hypothesis testing (MBHT) method to rectify the PPI data. Specifically, we regard any startle response signal as a deteriorated result from a hypothesis and reconstruct the complete and stable signal using a Bayesian hypothesis testing approach. The multi-scale analysis here is necessary because we cannot directly estimate the proper scale for a hypothesis even we have some statistical quantities of the whole population. By carrying out two sets of animal experiments using different medicines, we show that this MBHT method is much more robust than the conventional method. The analytic methodology proposed in this work can also be applied to similar animal experiments.
      PubDate: 10/17/2012 17:17:43
  • Surgical Decompression of Pudendal Nerve by Transperineal Approach Using a
           Balloon Probe

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Eric de Bisschop,Rajeshree Nundlall²Since 2009 may to 31 january 2012, 512 patients (371 females, 141 males) have benefited from a pudendal nerve (PN) decompression by transperineal approach using a ballon probe. These patients had clinical symptoms of pudendal neuralgia. Neurophysiological tests based on the staged sacral reflexes, on ultrasound investigations of pudendal vessels and on a pelvic floor ultrasounds evoked a zone of compressive hyperpressure at the level of the axis infrapiriformis area-ischiorectal fossa. All of these 512 patients, injection block at the level of the infrapiriformis area appeared positive between 1 to 9 months. Patients were known for this pathology since many years. Among these 512 patients, 66 had already PN decompression, 27 by transgluteal approach, 36 by transvaginal (♀)/transischiorectal (♂) approach and 3 by transperineal approach (Shakik extended) but without clinical efficiency.All of these 512 patients, surgical decompression was done by transperineal approach using a balloon probe.Surgical methodology, post-op follow up and results are reported hereby, which appear quite successful with few risks to make worse the pathology and no risk on pelvic static.
      PubDate: 10/17/2012 17:17:43
  • Quality of Life after Cardiac Rehabilitation for Patients with Heart
           Failure: 18 months follow-up

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Elias F. Porto,Claudia Kümpel,José R. Leite,Aline A. Andrade,Natália C. Oliveira,Leslie A. PortesThe aim of this study was to evaluate the effects of a supervised cardiac rehabilitation (CR) program on long-term quality of life (QoL) of patients with heart failure (HF).Methods: A sample of 21 HF patients, previously sedentary, NYHA II, was randomly divided into two groups: the CR group (N = 13) and the control group (CG = 8). The CR consisted of sessions of 120 minutes/day, 3 times/week,for 60 days. CR group performed their activities under supervision at a rehabilitation clinic, and CG received standard care and was instructed to exercise at home. All patients underwent a maximal symptom-limited test at the beginning and after 30 and 60 days of CR. QoL was monitored after 60-days, 6, 12 and 18 months of CR. Results:Two-way ANOVA for repeated measures, followed by Tukey’s test for statistical analysis showed significantimprovement in peak VO2 at 30 and 60-days of CR (p
      PubDate: 10/17/2012 17:17:43
  • A Transatlantic Comparative Study of Acute Dysphagia Services

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Roger D. Newman,Tony LongThis was the first study to compare acute dysphagia service provision directly between the UK and the US. It examined variations in acute dysphagia services between the UK and the US, determined clinicians’ perceptions of their own service and that of their transatlantic counterparts, and elicited the reason for variation. An online survey was distributed to randomly-allocated teaching hospitals in the UK and the US, and speech and language therapists working with acute dysphagia responded anonymously via an automated system. Content analysis was employed to convert free-text responses to numeric data, and then this and existing numeric responses were subjected to descriptive statistical analysis. Variability was high, with the US having on average 0.95 whole time equivalent more clinicians per hospital than the UK. This resulted in an increased number of new patients examined and increased frequency of review of existing patients compared to the UK. In contrast, the UK had significantly increased waiting times with no patient being assessed on the same day as referral (compared to 63.6% of US responses). Notable variation was also seen in objective or instrumental assessment, with most US patients receiving videofluoroscopy or fiberoptic endoscopic evaluation of swallowing (compared to only one UK hospital). Finance was found to be at the root of the variation. However, the more extensive US service was found to be more cost-effective.
      PubDate: 10/17/2012 17:17:43
  • Phytochemistry and Toxicity Studies of Telfairia Occidentalis Aqueous
           Leaves Extract on Liver Biochemical Indices in Wistar Rats

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Ekpenyong C. E,Akpan E. E,Udoh N. SThis study assessed the effect of oral administration of aqueous extract of Telfairiaoccidentalis (TO) leaves on liver biochemical indices in Wistar albino rats. Fifty rats weighing 150-200g were divided into 2 groups A and B, to test for acute (10 days) and sub-acute (4 weeks) effect respectively. Each group consisted of 25 rats, which were further divided into 5 sub-groups 1, 2, 3, 4 and 5. Sub-group 1 served as control and was orally gavaged with standard animal feed only, while sub-groups 2, 3, 4 and 5 were the test groups. In addition to the standard animal feed, 500mg/kg, 1000mg/kg, 2000mg/kg and 4000mg/kg of the extract was orally gavaged to the test groups 2, 3, 4 and 5 respectively. The standard animal feed given to the control and test groups contained the same amount of daily calories and protein. The acute and sub-acute administration of the extract caused significant differences in values of Aspartate amino Transferase(AST), Aspartate to Alanine amino Transferase(AST/ALT) ratio, Total protein, Albumin, Globulin, Albumin/Globulin ratio, Total body weight, Total and Conjugated bilirubin (P < 0.001) between test and control groups. Serum levels of other parameters were statistically non-significant. There was no obvious evidence of hepato-toxicity detected in this study.
      PubDate: 10/17/2012 17:17:43
  • Antioxidants Status in Acute Lymphoblastic Leukemic Patients

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  M. E. El-Sabagh,K. S. Ramadan,I. M. A. El-slam,A. M. IbrahimALL is the most common form of childhood cancer. Sufferers are treated with chemotherapy, which is associated with the production of free radicals. The aim of this study was to investigate the oxidative stress markers and some antioxidants status among Acute Lymphoblastic Leukemia patients. This study included 40 children newly diagnosed ALL before chemotherapy (mean age, 8.2 ±2) compared to 20 healthy controls (mean age, 7.6 ±1.4). The same of 40 patients of ALL undergoing chemotherapy treatment for 3 months. Oxidative stress, blood antioxidants status, kidney and liver profiles were measured in all groups. Our results showed that Antioxidants levels and Hb were significant decreased in ALL patients (P> 0.05) compared to control group, then antioxidants levels were more significant decreasing after ALL patients undergoing chemotherapy. In contrast MDA, 8dG, leukocytes count and Lymphoblast were significant increased (P> 0.05) compared to control group. Also, Urea and creatinine levels were found no significant difference between different groups, there was mild increase after chemotherapy but not significant. On other hand, ALT and AST were found no significant difference between healthy control and ALL patients. But their levels were found statistically significant to be increased in ALL patients after chemotherapy compared to before chemotherapy. In. conclusion, there are possible link between decreased antioxidants and increased levels of cells alterations due to oxidative damage in ALL, and this appear to be associated with complications of treatment
      PubDate: 10/17/2012 17:17:42
  • Pro-Angiogenic Mediators as Targets for Chemotherapy of Colorectal

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  N. M. Abdel-Hamid,M. Farid,A. Eldemeri,M. Atwa,N. AnbarPurpose Angiogenesis and chronic inflammation are codependent in pathogenesis of colorectal carcinoma (CRC). We aim to assess whether vascular endothelial growth factor (VEGF), nitric oxide (NO) and total lipase (TL) activity being contributors to angiogenesis, are targets for CRC chemotherapy. Methods we enrolled 60 subjects, 20 volunteers (10 males and 10 females) were assigned as control (group I). Forty CRC patients, 20 locally advanced (group II), subjected to surgery and chemotherapy (5-fluorouracil (5-FU, 425 mg/m2) plus leucovorin (LV, 20 mg/m2), IV, daily for 5 consecutive days, repeated every 3 to 5 weeks for 6 courses). The other 20 patients, were metastatic, (group III), followed up, given only adjuvant chemotherapy. Results Serum carcino embryonic antigen (CEA), cancer antigen (CA19.9), VEGF, NO concentrations and TL activity were significantly elevated in CRC compared to control and in Gp III compared to Gp II patients, but were down-regulated by chemotherapy. VEGF, NO and TL helped in diagnosis and follow up of CRC, although they were not returned to reference intervals. In conclusion, the response to chemotherapy of VEGF, NO and TL substantiates an anti-angiogenic potential in controlling CRC. AFP level was not changed in secondary metastatic hepatocellular carcinoma (HCC), seemingly, it rises only in primary HCCs
      PubDate: 10/17/2012 17:17:42
  • Evaluation of Hepatoprotective and Anticancer Properties of Aqueous Olive
           Leaf Extract in Chemically Induced Hepatocellular Carcinoma in Rats

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  N. M. Abdel-Hamid,M. A. Fawzy,M. A. El-MoselhyObjectives: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. We aimed to test the role of aqueous olive leaf extract (AOLE) in modulating metabolic disorders occurring in hepatic malignancy induced by trichloroacetic acid (TCA). Design: Eight groups of rats were assigned as follows: First, untreated normal control. Second, treated with 5-fluorouracil (5-FU), (75mg/kg), intraperitoneally (IP) once weekly for 3 weeks. Third, treated with oral AOLE (500mg/kg) once daily for 28 days. The 4th group co-treated with AOLE and 5-FU as mentioned above. The 5th group treated with oral daily doses of TCA (500mg/kg) for five days. The 6th group treated with TCA for 5 days, from the sixth day with 5-FU for 3 weeks. Group 7 given TCA then, with AOLE. Group 8 received TCA, 5-FU and AOLE. Blood samples were withdrawn after 28 days from carotid vein. Liver tissues were histologically studied. Results: TCA showed neoplastic tissue features, greatly improved by treatment with AOLE and 5-FU combination. TCA significantly increased blood ALT, AST, alkaline phosphatase (ALP) and acetyl CoA synthase (fatty acid synthase , FAS) activities, total bilirubin (T Bil) , triglycerides (TG), total glycosaminoglycans (TGAGs), alpha-fetoprotein (AFP), reduced serum total lipoprotein lipase (TLPL) activity. AOLE, combined with 5-FU produced a pronounced improvement in most of studied parameters. Conclusion: AOLE showed promising hepatoprotective and adjuvant anticancer properties if combined with 5-FU.
      PubDate: 10/17/2012 17:17:42
  • The Impact of Incubators on Noise Transmission Produced by High-Frequency
           Oscillatory Ventilator Inside the Neonatal Intensive Care Unit

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  H. Salama,A. Azzam,S. A. Omar,K. AbdulhadiUse of HFOV is a common practice inside the neonatal intensive care unit (NICU). There is a concern regarding the level of noise produced by HFOV inside the NICU. Objective: To evaluate and define the noise intensity produced by the high-frequency, oscillatory ventilator sensormedics (HFOV) and the impact of the incubator on the transmission of noise in different places inside the NICU. Methods: Using a noise analyzer, the noise produced by the HFOV sensormedics was measured in two setups: inside a quiet room, and inside the NICU during working hours. Measurements were repeated 2 times: first, inside and outside the tested incubator, second, inside and outside the next incubator. No human newborns were involved in the study; instead, a mannequin was used to simulate a newborn. The noise analyzer was placed next to mannequin mouth while inside the incubator and midway between the mannequin and the ventilator while measurements were taken outside the incubator. Each measurement was recorded against different HFOV ▲P and different frequency settings. Each measurement set lasted five minutes, where the highest and lowest readings were recorded every minute, and the average value of noise intensity was calculated.
      PubDate: 10/17/2012 17:17:42
  • Evaluation of Adenosine Deaminase (Ada) in Tuberculous Pleurisy

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  S. S. HaqueTuberculosis is a global health problem whose morbidity and mortality is increasing, as one-third of the world population is estimated to be infected with Mycobacterium tuberculosis and eight million new active cases occur annually commonest being pulmonary tuberculosis and is often associated with effusion. Delay in diagnosis and treatment results in poor prognosis. Adenosine deaminase estimation was done by Blake-Berman method. The purpose of this study is to find out the role of ADA levels in differentiation of tuberculous and non-tuberculous exudative pleural effusions of different etiologies. Adenosine deaminase values were compared between tuberculous and non-tuberculous groups and difference in these values was statistically significant (*p
      PubDate: 10/17/2012 17:17:42
  • Effect of Selenium on Carbimazole-Induced Histopathological and
           Histochemical Alterations in Prostate of Albino Rats

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Saber A. Sakr,Hoda A. Mahran,Amany E. Nofal,Saber A. Sakr,Hoda A. Mahran,Amany E. NofalCarbimazole is an antithyroid drug used in treatment of hyperthyroidism. The present study is undertaken to evaluate the effect of carbimazole in prostate of albino rats and the ameliorative role of selenium. Treating rats with carbimazole(1.35mg/Kg b.w) daily for 8 weeks caused distinct histological alterations in prostate gland compared with control group. The epithelial cells of prostatic acini exhibited degeneration. Hyperplasia were projected into the lumens of the prostatic acini or to the outside stroma. Most of the intertubular blood vessels were congested. Histomorphological results showed that the heights of the epithelial cells were significantly reduced and the thickness of smooth muscle layer increased. Prostate gland of animals treated with carbimazole showed gradual decrease in the polysaccharide, protein and nucleic acids contents. These results were time-dependent. Treating animals with carbimazole and selenium showed an improvement in the histological structure as well as histochemical components of the prostate gland. It is suggested that the ameliorative effect of selenium against the histological and histochemical changes induced by carbimazole may be due to its antioxidant properties.
      PubDate: 10/17/2012 17:17:42
  • Antifertility Effects of Ethanolic Extract of Xylopia aethiopica on Male
           Reproductive Organ of Wistar Rats

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Eze Kingsley NwangwaThe effects of ethanolic extract of Xylopia aethiopica on male reproductive organ in Wistar rats was studied. A total of twenty-four adult male rats were randomly divided into three experimental groups (n=8). Group 1 (control) was given rat chow and distilled water ad libitum, Group II and III received 0.5mls and 1.0mls of ethanolic extract of Xylopia aethiopica once daily for a period of 28 days. The results showed a significant (P
      PubDate: 10/17/2012 17:17:42
  • Rhinocerebral Mucormycosis: an Unusual Presentation

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Rajeshwari A,Gangadhara Somayaji K. SRhinocerebral mucormycosis is one of the most rapidly progressing and lethal form of fungal infection in humans which usually begins in the nose and paranasal sinuses and can extend to CNS. A 68 year old lady with poorly controlled diabetes presented with fever, disorientation, headache and left sided LMN type of facial palsy. ENT examination revealed a palatal ulcer and mucopus in middle meatus. MRI revealed an infarct in the territory of left superior cerebellar artery and haziness and mucosal thickening in the left maxillary and ethmoidal sinuses. Patient underwent endoscopic medial maxillectomy and debridement of palatal ulcer. Postoperative histopathology was suggestive of zygomycosis. Patient was subsequently treated with Amphotericin B for 4 weeks with good recovery. This case is being reported for its rarity as mucormycosis presenting with cerebellar signs has not been reported in the English literature so far.
      PubDate: 10/17/2012 17:17:42
  • A Simple and Effective Methodology for the Sulfonylation of Alcohols and
           Aniline under Solvent Free Condition at Room Temperature

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Reza TayebeeSulfonylation is an important reaction in the synthesis of naturally occurring bioactive molecules and is one of the most important methods for the protection of alcohols and amines. However, many efforts have been made towards the development of novel methods for the preparation of the target compounds. Most of these methods are involved the reaction of amine and alcohol compounds with sulfonyl chlorides by using an organic solvent, a base, and under high temperatures. Herein, we introduce our findings on the sulfonylation of aniline, 4-nitroaniline, and some alcohols bearing electron donating or withdrawing substituents with p-toluenesulfonyl chloride under very simple conditions in the absence of any expensive additive, as catalyst, and under solvent free condition at room temperature.
      PubDate: 10/17/2012 17:17:42
  • Antibiotic Resistance Profile of Gram Negative Bacteria Isolated from

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Sani R. A.,Garba S. A,Oyewole O. AAntibiotics resistance profiles of bacteria from surgical wounds were investigated in four (4) General Hospitals (Bida, Kontagora, Minna and Suleja) in Niger State. Five hundred (500) samples (i.e. Two hundred (200) samples in Minna, One hundred (100) samples each Suleja, Kontagora and Bida) of wound exudates from these general hospitals, were analysed. The results showed the presence of Klebsiella Pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Proteus vulgaris in the samples from the wounds. From the five hundred (500) samples collected from all locations, forty two (42) samples had Kl. pneumoniae, sixty four (64) samples had Ps. aeruginosa, fifty two (52) samples had P. vulgaris and one hundred and nine (109) samples had E. coli. E. coli was the most frequently isolated bacteria from wounds in all the locations, while Kl. pneumoniae was the least isolated from wounds in all the locations. All the bacteria were tested for sensitivity against tarivid, pefloxacin, ciprofloxacin, augmentin, gentamycin, streptomycin, ceporex, nalidixic acid, septrin, ampicillin, ampiclox, zinacef, amoxacillin, rocephin, erythromycin. Most of all the isolates were sensitive to ciprofloxacin, pefloxacin and Tarivid while others were resistant to remaining antibiotics. E. coli, Strept. pyogenes and S. aureus showed highest resistance profile and P. vulgaris, Kl. pneumoniae and Ps. aeruginosa showed least resistance profile to most antibiotics used.
      PubDate: 10/17/2012 17:17:42
  • Studies of Antioxidants and Xanthine Oxidase Inhibitory Potentials of Root
           and Aerial Parts of Medicinal Plant Capparis Spinosa L.

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Abderrahmane Baghiani,Djamila Ameni,Sabah Boumerfeg,Moufida Adjadj,Meriem Djarmouni,Noureddine Charef,Seddik Khennouf,Lekhmici ArrarCapparis spinosa aerial part and root extracts were prepared using solvents of varying polarity. Results showed that ethyl acetate extract (EAE) of the aerial part contains the highest concentration of phenolic compounds and flavonoids followed by the chloroform extract (CHE) of roots. The enzymatic methods were realised by the production of uric acid and reduction of cytochrome c. Result showed that all plant extracts were effective either in inhibiting the activity of XO or Cyt C. The IC50 ranges from 0.0226 ± 0.00019 to 4.32 ± 0.15g/l. The non enzymatic methods were conducted using in vitro techniques: In DPPH test, the radical scavenging activity for the root and aerial part extracts decreased in the following order CHE> EAE> CE and EAE> CE> CHE, respectively. In general the aerial part extracts had an antioxidant activity through ß-carotene-linoleate model system and ferric reducing ability greater than that of root part. In conclusion, Capparis spinosa appears to be a valuable plant and could be used to treat conditions where inhibition of XOR and free-radicals scavenging action are warranted.
      PubDate: 10/17/2012 17:17:42
  • Effects of Vitamin B6 on the Brain Glutamate Pyrovate Transaminase and
           Glutamate Oxaloacetate Transaminase in Young and Old Rats

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Manoochehr Messripour,Azadeh MesripourExcessive amounts of extracellular glutamate in brain are excitotoxic and lead to neuronal death. Glutamate pyrovate transamiase (GPT) and glutamate oxaloacetate transaminase (GOT) catalyze transamination of glutamate to alpha ketoglutarate. Because vitamin B6 is essential for the enzymes activities, this study was undertaken to examine the effect of vitamin B6 on age related changes of this enzyme in rat brain. Three and 30 months old male rats were injected with vitamin B6 and the animal’s brains were homogenized in phosphate buffer and the enzymes activities were measured in the supernatant. The activities of the enzymes in aged rats were significantly lower as compared to that of young animals. Vitamin B6 induced activation of the brain enzymes in both ages, however, the activation was significantly pronounced in aged animals. Significant activation of GPT and GOT by vitamin B6 in aged rat brain may be resulted from either lower availability of vitamin B6 in aged animals, or lower affinity of the enzymes for pyridoxal 5-phosphate, which is likely to be related to conformational changes during aging. It is suggested that vitamin B6 may restore the activity of these enzymes during the brain aging.
      PubDate: 10/17/2012 17:17:42
  • Total Antioxidant Capacity in Serum of Plasmodium f alciparum Malarial
           Infected Patients Receiving Artemisinin-Based Combination Therapy

    • Abstract: Publication year:  2011Source:American Journal of Medicine and Medical Sciences,  Volume  1,  Number  1  Onyesom I.,Osioma E.,Omoghene O.This study was undertaken to assess the effect of artemisin-based combination therapy (ACT) on serum total antioxidant capacity (TAC). Eighty (80) consenting patients infected with P. falciparum malaria (40 receiving ACT and 40 yet to be treated) and 40 uninfected individuals in apparent good health were selected. Serum total antioxidant capacity was determined by the trolox equivalent method as earlier described. Results show that P. falciparum malarial infection significantly reduced (p < 0.05) serum TAC (1.25±0.11mM) when compared with values obtained from the uninfected, healthy subjects (1.76±0.09mM) and the infected patients receiving ACT (1.57±0.13Mm). ACT treatment enhanced serum TAC by 25.6% in comparison with the value obtained from malarial infected patients yet to receive treatment. Thus, treatment of P. falciparum malarial infection with ACT significantly (p
      PubDate: 10/17/2012 17:17:42
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