Subjects -> MEDICAL SCIENCES (Total: 8690 journals)
    - ALLERGOLOGY AND IMMUNOLOGY (220 journals)
    - ANAESTHESIOLOGY (121 journals)
    - CARDIOVASCULAR DISEASES (338 journals)
    - CHIROPRACTIC, HOMEOPATHY, OSTEOPATHY (21 journals)
    - COMMUNICABLE DISEASES, EPIDEMIOLOGY (236 journals)
    - DENTISTRY (294 journals)
    - DERMATOLOGY AND VENEREOLOGY (163 journals)
    - EMERGENCY AND INTENSIVE CRITICAL CARE (124 journals)
    - ENDOCRINOLOGY (151 journals)
    - FORENSIC SCIENCES (42 journals)
    - GASTROENTEROLOGY AND HEPATOLOGY (189 journals)
    - GERONTOLOGY AND GERIATRICS (138 journals)
    - HEMATOLOGY (158 journals)
    - HYPNOSIS (4 journals)
    - INTERNAL MEDICINE (178 journals)
    - LABORATORY AND EXPERIMENTAL MEDICINE (99 journals)
    - MEDICAL GENETICS (58 journals)
    - MEDICAL SCIENCES (2415 journals)
    - NURSES AND NURSING (370 journals)
    - OBSTETRICS AND GYNECOLOGY (207 journals)
    - ONCOLOGY (386 journals)
    - OPHTHALMOLOGY AND OPTOMETRY (141 journals)
    - ORTHOPEDICS AND TRAUMATOLOGY (170 journals)
    - OTORHINOLARYNGOLOGY (83 journals)
    - PATHOLOGY (100 journals)
    - PEDIATRICS (275 journals)
    - PHYSICAL MEDICINE AND REHABILITATION (158 journals)
    - PSYCHIATRY AND NEUROLOGY (833 journals)
    - RADIOLOGY AND NUCLEAR MEDICINE (192 journals)
    - RESPIRATORY DISEASES (105 journals)
    - RHEUMATOLOGY (79 journals)
    - SPORTS MEDICINE (81 journals)
    - SURGERY (406 journals)
    - UROLOGY, NEPHROLOGY AND ANDROLOGY (155 journals)

MEDICAL SCIENCES (2415 journals)            First | 3 4 5 6 7 8 9 10 | Last

Showing 1201 - 1400 of 3562 Journals sorted alphabetically
Journal of Evaluation In Clinical Practice     Hybrid Journal   (Followers: 6)
Journal of Evidence-Based Healthcare     Open Access   (Followers: 1)
Journal of Evidence-Based Integrative Medicine     Open Access   (Followers: 18)
Journal of Evidence-Based Medicine     Partially Free   (Followers: 4)
Journal of Exercise Science & Fitness     Open Access   (Followers: 29)
Journal of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
Journal of Family and Community Medicine     Open Access   (Followers: 3)
Journal of Family Medicine and Primary Care     Open Access   (Followers: 11)
Journal of Foot and Ankle Research     Open Access   (Followers: 6)
Journal of Forensic Science and Research     Open Access   (Followers: 2)
Journal of Gandaki Medical College-Nepal     Open Access  
Journal of Generic Medicines     Hybrid Journal   (Followers: 2)
Journal of Geographical Sciences     Hybrid Journal   (Followers: 1)
Journal of Global Antimicrobial Resistance     Hybrid Journal   (Followers: 3)
Journal of Hand Therapy     Hybrid Journal   (Followers: 19)
Journal of Head & Neck Physicians and Surgeons     Open Access   (Followers: 2)
Journal of Health & Medical Informatics     Open Access   (Followers: 62)
Journal of Health and Biological Sciences     Open Access   (Followers: 1)
Journal of Health Design     Open Access   (Followers: 1)
Journal of Health Economics and Outcomes Research     Open Access   (Followers: 1)
Journal of Health Promotion and Behavior     Open Access  
Journal of Health Research and Reviews     Open Access  
Journal of Health Science and Medical Research     Open Access  
Journal of Health Science Research     Open Access  
Journal of Health Sciences     Open Access   (Followers: 1)
Journal of health sciences     Open Access  
Journal of Health Sciences / Sağlık Bilimleri Dergisi     Open Access  
Journal of Health Sciences and Medicine     Open Access  
Journal of Health Sciences and Medicine     Open Access   (Followers: 6)
Journal of Health Sciences and Surveillance System     Open Access  
Journal of Health Sciences Scholarship     Open Access  
Journal of Health Specialties     Open Access  
Journal of Health Studies     Open Access  
Journal of Healthcare Informatics Research     Hybrid Journal   (Followers: 1)
Journal of Heavy Metal Toxicity and Diseases     Open Access  
Journal of Helminthology     Hybrid Journal   (Followers: 2)
Journal of Herbs Spices & Medicinal Plants     Hybrid Journal  
Journal of HIV for Clinical and Scientific Research     Open Access   (Followers: 2)
Journal of Hospital Medicine     Hybrid Journal   (Followers: 11)
Journal of Huazhong University of Science and Technology [Medical Sciences]     Hybrid Journal  
Journal of Human Hypertension     Hybrid Journal   (Followers: 3)
Journal of Human Rhythm     Open Access  
Journal of Human Transcriptome     Open Access  
Journal of Ideas in Health     Open Access  
Journal of Inflammation     Open Access   (Followers: 2)
Journal of Inflammation Research     Open Access  
Journal of Injury and Violence Research     Open Access   (Followers: 6)
Journal of Innovation in Health Informatics     Open Access   (Followers: 17)
Journal of Institute of Medicine     Open Access  
Journal of Insulin Resistance     Open Access   (Followers: 1)
Journal of Interactional Research in Communication Disorders     Hybrid Journal   (Followers: 5)
Journal of Interferon & Cytokine Research     Hybrid Journal   (Followers: 3)
Journal of International Medical Research     Open Access   (Followers: 3)
Journal of Interventional Medicine     Open Access   (Followers: 1)
Journal of Investigative Medicine     Hybrid Journal   (Followers: 3)
Journal of Islamabad Medical & Dental College     Open Access   (Followers: 2)
Journal of Istanbul Faculty of Medicine     Open Access  
Journal of Karnali Academy of Health Sciences     Open Access   (Followers: 1)
Journal of Kathmandu Medical College     Open Access   (Followers: 1)
Journal of King Abdulaziz University : Medical Sciences     Open Access   (Followers: 2)
Journal of Laboratory Medicine     Hybrid Journal   (Followers: 27)
Journal of Laryngology and Voice     Open Access   (Followers: 11)
Journal of Lasers in Medical Sciences     Open Access  
Journal of Law, Medicine & Ethics     Hybrid Journal   (Followers: 28)
Journal of Legal Medicine     Hybrid Journal   (Followers: 7)
Journal of Limb Lengthening & Reconstruction     Open Access  
Journal of Lumbini Medical College     Open Access   (Followers: 1)
Journal of Mahatma Gandhi Institute of Medical Sciences     Open Access  
Journal of Manipulative and Physiological Therapeutics     Hybrid Journal   (Followers: 6)
Journal of Manmohan Memorial Institute of Health Sciences     Open Access   (Followers: 1)
Journal of Marine Medical Society     Open Access  
Journal of Materials Science : Materials in Medicine     Hybrid Journal   (Followers: 4)
Journal of Maternal and Child Health     Open Access  
Journal of Mechanics in Medicine and Biology     Hybrid Journal  
Journal of Medical and Biological Engineering     Hybrid Journal   (Followers: 4)
Journal of Medical and Biomedical Sciences     Open Access   (Followers: 2)
Journal of Medical Case Reports     Open Access   (Followers: 1)
Journal of Medical Cases     Open Access   (Followers: 6)
Journal of Medical Colleges of PLA     Full-text available via subscription  
Journal of Medical Disorders     Open Access  
Journal of Medical Economics     Hybrid Journal   (Followers: 8)
Journal of Medical Education and Curricular Development     Open Access   (Followers: 6)
Journal of Medical Ethics     Partially Free   (Followers: 27)
Journal of Medical Ethics and History of Medicine     Open Access   (Followers: 19)
Journal of Medical Humanities     Hybrid Journal   (Followers: 21)
Journal of Medical Hypotheses and Ideas     Open Access  
Journal of Medical Imaging and Health Informatics     Full-text available via subscription   (Followers: 1)
Journal of Medical Investigation and Practice     Open Access  
Journal of Medical Laboratory and Diagnosis     Open Access  
Journal of Medical Law and Ethics     Full-text available via subscription   (Followers: 17)
Journal of Medical Microbiology     Full-text available via subscription   (Followers: 6)
Journal of Medical Sciences     Open Access  
Journal of Medical Sciences     Open Access  
Journal of Medical Screening     Hybrid Journal   (Followers: 6)
Journal of Medical Signals and Sensors     Open Access   (Followers: 3)
Journal of Medical Society     Open Access  
Journal of Medical Systems     Hybrid Journal  
Journal of Medical Toxicology     Hybrid Journal   (Followers: 6)
Journal of Medical Ultrasound     Open Access   (Followers: 2)
Journal of Medicinal Botany     Open Access  
Journal of Medicinal Chemistry     Hybrid Journal   (Followers: 208)
Journal of Medicine     Open Access   (Followers: 1)
Journal of Medicine and Biomedical Research     Open Access   (Followers: 1)
Journal of Medicine and Philosophy     Hybrid Journal   (Followers: 9)
Journal of Medicine and the Person     Hybrid Journal  
Journal of Medicine in Scientific Research     Open Access  
Journal of Medicine in the Tropics     Open Access  
Journal of Medicine Research and Development     Open Access   (Followers: 3)
Journal of Medicine, Physiology and Biophysics     Open Access   (Followers: 5)
Journal of Medicines Development Sciences     Open Access   (Followers: 1)
Journal of Metabolomics & Systems Biology     Open Access   (Followers: 2)
Journal of Mind and Medical Sciences     Open Access   (Followers: 1)
Journal of Molecular Medicine     Hybrid Journal   (Followers: 11)
Journal of Movement Disorders     Open Access   (Followers: 2)
Journal of Multidisciplinary Research in Healthcare     Open Access   (Followers: 3)
Journal of Muscle Research and Cell Motility     Hybrid Journal   (Followers: 1)
Journal of Nanotechnology in Engineering and Medicine     Full-text available via subscription   (Followers: 6)
Journal of Nanotheranostics     Open Access   (Followers: 1)
Journal of Natural Medicines     Hybrid Journal  
Journal of Natural Science, Biology and Medicine     Open Access   (Followers: 3)
Journal of Nature and Science of Medicine     Open Access   (Followers: 4)
Journal of Negative and No Positive Results     Open Access  
Journal of Nepalgunj Medical College     Open Access  
Journal of Neurocritical Care     Open Access  
Journal of Neurodegenerative Diseases     Open Access   (Followers: 2)
Journal of Neurorestoratology     Open Access  
Journal of Neuroscience and Neurological Disorders     Open Access  
Journal of Nobel Medical College     Open Access  
Journal of Obesity and Bariatrics     Open Access   (Followers: 2)
Journal of Occupational Health     Open Access  
Journal of Occupational Therapy Education     Open Access   (Followers: 12)
Journal of Ocular Biology, Diseases, and Informatics     Hybrid Journal  
Journal of Oral Biology and Craniofacial Research     Full-text available via subscription  
Journal of Oral Health and Craniofacial Science     Open Access  
Journal of Orofacial Sciences     Open Access  
Journal of Otorhinolaryngology, Hearing and Balance Medicine     Open Access   (Followers: 1)
Journal of Ovarian Research     Open Access  
Journal of Ozone Therapy     Open Access  
Journal of Palliative Medicine     Hybrid Journal   (Followers: 47)
Journal of Paramedical Sciences & Rehabilitation     Open Access  
Journal of Parkinsonism and Restless Legs Syndrome     Open Access   (Followers: 2)
Journal of Parkinson’s Disease and Alzheimer’s Disease     Open Access   (Followers: 1)
Journal of Participatory Medicine     Open Access  
Journal of Patan Academy of Health Sciences     Open Access  
Journal of Pathogens     Open Access   (Followers: 1)
Journal of Patient Experience     Open Access  
Journal of Patient Safety and Risk Management     Hybrid Journal   (Followers: 2)
Journal of Patient-Centered Research and Reviews     Open Access  
Journal of Patient-Reported Outcomes     Open Access  
Journal of Periodontal Research     Hybrid Journal  
Journal of Personalized Medicine     Open Access   (Followers: 3)
Journal of Pest Science     Hybrid Journal   (Followers: 1)
Journal of Pharmaceutical Policy and Practice     Open Access   (Followers: 4)
Journal of Physiobiochemical Metabolism     Hybrid Journal   (Followers: 2)
Journal of Physiology-Paris     Hybrid Journal   (Followers: 2)
Journal of Pioneering Medical Sciences     Open Access  
Journal of Postgraduate Medicine     Open Access  
Journal of Pregnancy     Open Access   (Followers: 4)
Journal of Prevention & Intervention Community     Hybrid Journal   (Followers: 7)
Journal of Preventive Medicine and Public Health     Open Access  
Journal of Primary Prevention     Hybrid Journal   (Followers: 7)
Journal of Prosthodontic Research     Full-text available via subscription   (Followers: 1)
Journal of Prosthodontics     Hybrid Journal   (Followers: 2)
Journal of Receptor, Ligand and Channel Research     Open Access   (Followers: 1)
Journal of Regenerative Medicine     Partially Free   (Followers: 4)
Journal of Research in Medical Sciences     Open Access   (Followers: 2)
Journal of Science and Applications : Biomedicine     Open Access   (Followers: 1)
Journal of Science and Technology (Ghana)     Open Access   (Followers: 3)
Journal of Scientific Innovation in Medicine     Open Access  
Journal of Scientific Perspectives     Open Access   (Followers: 1)
Journal of Sensory Studies     Hybrid Journal   (Followers: 4)
Journal of Shaheed Suhrawardy Medical College     Open Access  
Journal of Shoulder and Elbow Arthroplasty     Open Access  
Journal of Sleep Disorders : Treatment & Care     Hybrid Journal   (Followers: 10)
Journal of South American Earth Sciences     Hybrid Journal   (Followers: 5)
Journal of Spinal Cord Medicine     Hybrid Journal   (Followers: 5)
Journal of Spinal Disorders & Techniques     Hybrid Journal   (Followers: 2)
Journal of Sports Medicine and Allied Health Sciences : Official Journal of the Ohio Athletic Trainers Association     Open Access   (Followers: 1)
Journal of Stem Cell Therapy and Transplantation     Open Access   (Followers: 1)
Journal of Stomal Therapy Australia     Full-text available via subscription   (Followers: 1)
Journal of Strength and Conditioning Research     Hybrid Journal   (Followers: 77)
Journal of Substance Use     Hybrid Journal   (Followers: 15)
Journal of Surgical Academia     Open Access   (Followers: 1)
Journal of Surgical and Clinical Research     Open Access  
Journal of Surgical Case Reports     Open Access  
Journal of Surgical Education     Full-text available via subscription   (Followers: 3)
Journal of Surgical Technique and Case Report     Open Access  
Journal of Systemic Therapies     Full-text available via subscription   (Followers: 3)
Journal of Taibah University Medical Sciences     Open Access  
Journal of Telemedicine and Telecare     Hybrid Journal   (Followers: 12)
Journal of The Academy of Clinical Microbiologists     Open Access  
Journal of the American Association for Laboratory Animal Science     Full-text available via subscription   (Followers: 9)
Journal of the American College of Certified Wound Specialists     Hybrid Journal   (Followers: 2)
Journal of the American College of Clinical Wound Specialists     Hybrid Journal   (Followers: 2)
Journal of the American Medical Directors Association     Hybrid Journal   (Followers: 5)
Journal of the American Medical Informatics Association : JAMIA     Hybrid Journal   (Followers: 36)
Journal of the American Podiatric Medical Association     Full-text available via subscription   (Followers: 7)
Journal of the Anatomical Society of India     Full-text available via subscription  
Journal of the Anus, Rectum and Colon     Open Access  
Journal of The Arab Society for Medical Research     Open Access  

  First | 3 4 5 6 7 8 9 10 | Last

Similar Journals
Journal Cover
Journal of Medical Hypotheses and Ideas
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2251-7294
Published by Elsevier Homepage  [3200 journals]
  • Psyllium seed may be effective in the treatment of gastroesophageal reflux
           disease (GERD) in patients with functional constipation

    • Authors: Mousalreza Hosseini; Masoumeh Salari; Roshanak Salari
      Abstract: Publication date: Available online 2 December 2015
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Mousalreza Hosseini, Masoumeh Salari, Roshanak Salari
      GERD, return of stomach contents into the esophagus, is one of the most common gastrointestinal disorders in medicine. Its common symptoms are heartburn and acid reflux. Usually, patients with GERD history develop clinical signs such as heartburn accompanied by functional constipation. Omeprazole, a proton pump inhibitor (PPIs), is a drug of choice for GERD but all patients do not respond to the drug and long-term use of these drugs leads to infections. According to the same physiopathology mechanisms of chronic constipation and GERD, improvement of functional constipation may be effective in relieving symptoms of GERD. According to the effectiveness of psyllium seeds in chronic constipation symptoms, it is predicted to be effective in treating GERD in patients with chronic constipation.
      Graphical abstract image

      PubDate: 2015-12-05T03:16:27Z
      DOI: 10.1016/j.jmhi.2015.11.002
      Issue No: Vol. 9, No. 2 (2015)
       
  • Mesenchymal Stem Cells Injection with Core Decompression in the Treatment
           of Kienbock disease

    • Authors: Saeed Reza Mehrpour; Alireza Mobasseri; Behzad Amoozgar
      Abstract: Publication date: Available online 1 December 2015
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Saeed Reza Mehrpour, Alireza Mobasseri, Behzad Amoozgar
      Treatment of Kienbock disease (the avascular necrosis of the lunate) is a matter of debate. Current surgical modalities have their limitations and potential complications. Those modalities are also not based on pathophysiology of the disease. Here we introduce a novel therapeutic option by combining the autologous mesenchymal stem cell injection and the core decompression procedure in the treatment of Kienbock disease. We hypothesized that micro-drilling of the lunate removes the necrotic tissue and induces new bone formation while injection of mesenchymal stem cell provides a poll of multi-potent cells to replace the dead bone. This new treatment modality would provide synergistic effects of the two therapeutic options beside lower potential complications while eliminating the need for current surgical operations.
      Graphical abstract image

      PubDate: 2015-12-05T03:16:27Z
      DOI: 10.1016/j.jmhi.2015.11.001
      Issue No: Vol. 9, No. 2 (2015)
       
  • The Potential Use of Biogas Producing Microorganisms in Radiation
           Protection

    • Authors: Hamid Abdollahi; Mohammadreza Atashzar; Maryam Amini
      Pages: 67 - 71
      Abstract: Publication date: Available online 9 April 2015
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Hamid Abdollahi , Mohammadreza Atashzar , Maryam Amini
      Radiation induced injury is a limiting factor in radiation related approaches from earth to space. Inductions of a wide spectrum of damages in radiotherapy patients due to unwanted normal tissues irradiation and space radiation related diseases in astronauts have been caused many limitations in cancer treatment and space missions. There are many radiation protection/mitigation approaches including: physical, chemical, biological and physiological methods. Radiation protection using these methods is expensive and also has many problems including acute toxicities and difficulties in their targeting to normal tissues. Based on experimental and hypothetical data, showing that medical/biological gases have many protective effects such as antioxidant, anti-inflammatory, anti-apoptotic, and induction of radioresistance, we hypothesize that similar gases which have been produced by microorganisms (biogases) have those properties and may be used as radiation mitigators/protectors in radiation related approaches such as radiotherapy, radiation accidents and in space missions. Isolation microorganism in safe laboratory conditions in enough amounts, finding non-toxic dose of microorganisms that provide highest radioprotection percent, dose reduction factor (DRF) calculation to compare the radioprotective efficacy of the microorganisms, finding the best targeting techniques to deliver those microorganisms into normal tissues, genetically manipulations of microorganism to achieve the highest amount of biogases with lowest side effects can be done for testing the hypothesis.
      Graphical abstract image

      PubDate: 2015-04-12T18:30:49Z
      DOI: 10.1016/j.jmhi.2015.04.001
      Issue No: Vol. 9, No. 2 (2015)
       
  • Implication of bisphosphonate use in the treatment of SAPHO syndrome: case
           report and discussion of current literature

    • Authors: Patricia Gorecki; Philipp Stockmann; Jörg H.W. Distler; Wolfgang Wuest; Daniela Schmidt; Friedrich Wilhelm Neukam; Emeka Nkenke; Falk Wehrhan
      Pages: 72 - 78
      Abstract: Publication date: Available online 25 April 2015
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Patricia Gorecki , Philipp Stockmann , Jörg H.W. Distler , Wolfgang Wuest , Daniela Schmidt , Friedrich Wilhelm Neukam , Emeka Nkenke , Falk Wehrhan
      Even though increasing knowledge is emerging about synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome its pathogenesis remains enigmatic. Women are preferentially affected by SAPHO syndrome. Here we present the case of a 39-year-old woman suffering from this syndrome whose bone involvement was first interpreted as diffuse sclerosing osteomyelitis of the mandible. As treatment with clindamycin did not improve the symptoms, the decision was made to administer bisphosphonates intravenously. This treatment led to a rapid improvement in symptoms, which could be explained by the apparent tendency of bisphosphonates to exert a positive effect on the jaw. With this case report we attempt to offer an explanation for the influence of this group of medications on patients suffering from SAPHO syndrome with mandibular involvement.
      Graphical abstract image

      PubDate: 2015-04-27T11:54:46Z
      DOI: 10.1016/j.jmhi.2015.04.002
      Issue No: Vol. 9, No. 2 (2015)
       
  • The developmental perspective of the chronic alcoholism: who’s holding
           the burden of proof'

    • Authors: Zihni Sulaj; Altin Kuqo; Gentian Vyshka
      Pages: 79 - 85
      Abstract: Publication date: Available online 14 July 2015
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Zihni Sulaj , Altin Kuqo , Gentian Vyshka
      Chronic alcoholism is a public health issue, and several theoretical frameworks have been proposed to explain its nature. The developmental approach to chronic alcoholism has a double contour, with neurobiological theories counting on several aspects of the deleterious effects exerted from ethanol over neural structures. Psychological and neurobiological theories are not intrinsically contradictory to each other. The importance of early experiences and the potential sensory clues leading to ethanol-self administration are integral parts of the developmental neurobiology of an alcoholic. The developmental theories need to consider any further the accumulative and deleterious effects of ethanol during the nervous system maturation.

      PubDate: 2015-07-15T20:01:57Z
      DOI: 10.1016/j.jmhi.2015.07.001
      Issue No: Vol. 9, No. 2 (2015)
       
  • Can nanoparticles be beneficial for the early detection and treatment of
           Alzheimer Disease

    • Authors: Somayeh Mirsadeghi; Rassoul Dinarvand
      Pages: 86 - 87
      Abstract: Publication date: Available online 2 September 2015
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Somayeh Mirsadeghi, Rassoul Dinarvand
      Alzheimer is denominated the disease of century and is a kind of dementia that causes problems with memory, thinking and behavior. Symptoms typically develop slowly and acquire worse over time, turning into severe enough to interfere with daily tasks. Alzheimer’s disease (AD) represents for 60 to 80 percent of dementia cases, but is not a normal part of aging although the greatest known risk factor is increasing age, and the majority of people with AD are 65 and older. However, AD is not just a disease of old age. Up to 5 percent of people with the disease have early onset AD (also known as younger-onset), which often appears when someone is in their 40s or 50s .AD typically progresses slowly in three general stages: mild (early-stage), moderate (middle-stage), and severe (late-stage). Since AD affects people in different ways, each person will experience symptoms or progress through AD stages differently but early detection of symptoms is very important.

      PubDate: 2015-09-06T08:53:24Z
      DOI: 10.1016/j.jmhi.2015.08.001
      Issue No: Vol. 9, No. 2 (2015)
       
  • An appraisal of the Journal of Medical Hypotheses and Ideas: a medium for
           evidence-based scholarly communications

    • Authors: Armen Yuri Gasparyan
      Pages: 88 - 89
      Abstract: Publication date: Available online 9 September 2015
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Armen Yuri Gasparyan


      PubDate: 2015-09-10T09:06:49Z
      DOI: 10.1016/j.jmhi.2015.09.002
      Issue No: Vol. 9, No. 2 (2015)
       
  • Differentiation of Human Endometrial Stem Cells into germ cell - like cell
           in Fibrin Scaffold

    • Authors: Maryam Roya Ramzgouyan; Jafar Ai
      Pages: 90 - 93
      Abstract: Publication date: Available online 8 September 2015
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Maryam Roya Ramzgouyan, Jafar Ai
      Recent studies on stem cells differentiation into germ cells have changed scientists ‘ attitude to reproductive problems as well as infertility topics. It is supposed there are promising and new approaches in treatment of infertile couples and numerous advances will be made in reproductive medicine in near future. Application of embryonic stem cells for clinical trials is limited due to high potent of tumorogenicity and ethical issues .Therefore, pluripotent cells taken from adult tissues or organs, could be a good alternative for gamete production. Herein, we hypothesize to stimulate human endometrial stem cells (hEnSCs) differentiation into germ cell-like cells by culturing in retinoic acid (RA) as 2D medium and then in fibrin as 3D scaffold. Germ cell markers such as DAZL, DDX4 and Dppa3, will be assessed by immunofluorescence and real-time PCR. Fibrin mechanical properties will be examined by rheology analysis and cell viability will be determined by MTT assay. Specific markers expression and the cells’ integrity will be detected by immunofluorescence staining and SEM analysis respectively. We suggest differentiation of hEnSCs into germ cell-like cells in a medium containing 10-5 M RA in which the specific markers were expressed properly in both 2D and 3D medium cultures. Additionally, fibrin scaffold will offer a proper 3D scaffold for hEnSCs-derived germ cell-like cells.
      Graphical abstract image

      PubDate: 2015-09-10T09:06:49Z
      DOI: 10.1016/j.jmhi.2015.09.001
      Issue No: Vol. 9, No. 2 (2015)
       
  • Induction of spontaneous neo-angiogenesis and tube formation in human
           endometrial stem cells by bioglass

    • Authors: Atefeh Shamosi; Mehdi Farokhi; Jafar Ai; Esmaeel Sharifi
      Pages: 94 - 98
      Abstract: Publication date: Available online 30 September 2015
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Atefeh Shamosi, Mehdi Farokhi, Jafar Ai, Esmaeel Sharifi
      Endothelial dysfunction is a broad pathological disorder of the endothelium (innermost layer of blood vessels) which is assigned by vasoconstriction, thrombosis and ischemic diseases, alone or with other disorders such as coronary artery disease, hypertension and atherosclerosis. The fundamental imperfection of endothelial layer injury due to decrease the number of functional endothelial progenitor cells and inhibition of endothelial progenitor cell differentiation, resulting into impairment of angiogenesis, vasculogenesis, tube formation properties and endothelial regeneration. Multiple significant therapeutic achievements in impediment and treatment of vascular diseases include the use of antithrombotic agents, statin class of drugs, lifestyle changes, and revascularization therapies. Nevertheless, a certain number of patients with endothelial dysfunction disease are resistant to the usual therapies, so new therapeutic strategies for endothelial dysfunction disease are urgently needed. Recent studies show that stem cell-based therapy has important promise for repair and treatment of vascular dysfunction. In this study, we describe a novel choice for treatment of endothelial dysfunction in vascular regenerative medicine via the human endometrial stem cell culture (as a new source for the increasing the number of endothelial progenitor cells) with Bioglass(angiogenic agent) to investigate the enhancing expression of CD34, CD31 and gene markers of endothelial progenitor cells and endothelial cells. In the end, application of immuno-privileged, readily available sources of adult stem cells like human endometrial stem cells with bioglass would be a promising strategy to increase the number of endothelial progenitor cells and promote spontaneous angiogenesis needed in endothelial layer repair and regeneration.
      Graphical abstract image

      PubDate: 2015-10-01T17:00:56Z
      DOI: 10.1016/j.jmhi.2015.09.004
      Issue No: Vol. 9, No. 2 (2015)
       
  • Reprogramming of Adult Stem/Progenitor Cells into iPSCs Without
           Reprogramming Factors

    • Authors: Behnam Ebrahimi
      Pages: 99 - 103
      Abstract: Publication date: Available online 30 September 2015
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Behnam Ebrahimi
      Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) has attracted considerable attention in both the scientific and public communities. This is due to the importance of iPSCs in drug screening, disease modeling, cell transplantation therapies and regenerative medicine. A lot of efforts have been accomplished to generate iPSCs with fewer reprogramming factors and with higher efficiencies. It has been shown that removal of reprogramming barriers increases the efficiency of iPSC generation from differentiated cells up to 90%. Interestingly, having approximately fast cell cycle kinetics, plasticity and endogenous expression of particular pluripotency regulators make adult stem/progenitor cells potentially elite cells poised to become iPSCs. Moreover, it has been demonstrated that adult stem/progenitor cells are more amenable to pluripotent reprogramming than mature cells. Accordingly, it is hypothesized that certain adult stem cells could be reprogrammed into iPSCs without overexpression of exogenous pluripotency transcription factors by only combinatorial modulation of barriers and enhancers and relying on the endogenous expression of key reprogramming factors (e.g. Oct4, Sox2, etc.).
      Graphical abstract image

      PubDate: 2015-10-01T17:00:56Z
      DOI: 10.1016/j.jmhi.2015.09.003
      Issue No: Vol. 9, No. 2 (2015)
       
  • “Post Modern Medicine” would be “calculable and energy-based
           medicine”: A hypothesis paper

    • Authors: Hila Yousefi; Nima Rezaei
      Pages: 104 - 106
      Abstract: Publication date: December 2015
      Source:Journal of Medical Hypotheses and Ideas, Volume 9, Issue 2
      Author(s): Hila Yousefi, Nima Rezaei
      The approach of current modern medicine towards human body system is solely molecular and cellular. Despite the great efforts, current medicine has not been successful enough, and spectrum of disorders has remained untreated. It emphasizes on the essential need for more careful approach to the body system. Prior to the molecules and cells human body system has been composed of countless of atomic and subatomic particles, considering laws of quantum physics and the principles of chemistry the energy levels of energy photons of these particles play the most crucial role in designing human body characteristics and conformations.In this hypothesis paper, we outline the novel approach towards human body system and concluded that exposing a form of energy to the energy photons of the subatomic particles in one of the molecules of oxygen bound to phosphor in phosphate group would be beneficial therapeutic method regarding all types of cancers, refuting concerns of variety of gene mutations and signaling cascades engaged with engendering and progression of various types of cancers.
      Graphical abstract image

      PubDate: 2015-11-13T21:54:27Z
      DOI: 10.1016/j.jmhi.2015.09.005
      Issue No: Vol. 9, No. 2 (2015)
       
  • Near-IR absorbing quantum dots might be usable for growth factor-based
           differentiation of stem cells

    • Authors: Hassan Niknejad; Masoumeh Mirmasoumi; Behzad Torabi; Nafiseh Deheshkar-Farahani
      Pages: 24 - 28
      Abstract: Publication date: Available online 2 February 2015
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Hassan Niknejad , Masoumeh Mirmasoumi , Behzad Torabi , Nafiseh Deheshkar Farahani
      For stem cell therapy of degenerative diseases, it is necessary to differentiate stem cells into the specific lineage. There are several growth factors which have been used for differentiation of stem cells. Some growth factors can dose-dependently induce differentiation of stem cells so that the increase of growth factor concentration results in production of the higher level of differentiated cells. However, due to the toxicity of some differentiation factors (e.g. retinoic acid), the lower dose of growth factors for the specific lineage differentiation of stem cells is desirable. This paper suggests a new approach in the field of controlled growth factor delivery system using semiconductor nanocrystals; known as quantum dots (QDs). This system contains polymeric microencapsulated growth factor which is conjugated to near infrared (NIR) absorbing QDs. The control release of growth factors from microcapsules in the culture plates can be achieved by irradiation. To modulate growth factor release in response to stem cells needs for differentiation, the intensity and period of irradiation will be controlled. Our hypothesis is based on the fact that QDs can absorb NIR energy and by excitation of electrons and then vibrational relaxation of them become heated when they were irradiated and then release growth factors. We believe that controlled growth factors delivery through the suggested system is an effective method to reduce the amount of growth factors required for differentiation of stem cells.
      Graphical abstract image

      PubDate: 2015-02-07T11:08:49Z
      DOI: 10.1016/j.jmhi.2015.01.003
      Issue No: Vol. 9, No. 1 (2015)
       
  • To decipher the hypoxic pulmonary hypertension: vascular heterogeneity and
           the hypothesis of hypoxic responsive threshold

    • Authors: Hongwei Ma; Dunquan Xu; Yaqiong Wu; Yongtao Ma; Zhichao Li
      Pages: 29 - 37
      Abstract: Publication date: Available online 18 February 2015
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Hongwei Ma , Dunquan Xu , Yaqiong Wu , Yongtao Ma , Zhichao Li
      Pulmonary hypertension (PH) is a complex and multi-factorial chronic disease characterized by progressively increased pulmonary vascular resistance and vascular remodeling, and it has been recognized as ‘the cancer of cardiovascular diseases’ because of its high morbidity and mortality. Pathophysiological changes of pulmonary arteries, which implicate endothelial dysfunction, smooth muscle cell proliferation, and increased vasoconstriction, decrease the lumen area of the pulmonary microvasculature, optimizing the pulmonary ventilation/perfusion ratio as well as causing fixed elevation of pulmonary resistance. Among various types of PH, hypoxic pulmonary hypertension (HPH) which occurs in patients with cardiopulmonary disease or in residents at high altitude has aroused great interest in researchers. Intriguingly, synchronously exposed to the hypoxic circumstances, the peripheral vessels make responses different from pulmonary arteries, which, besides the effects exerted by nervus and the microenvironment (involving the inflammatory mediators, angiotensin II and other ingredients), has always been expounded as the vascular heterogeneity. Nevertheless, nobody has articulated such heterogeneity and its mechanism to date. Based on our prior experiments, we propound the hypothesis of hypoxic responsive threshold (HRT) for the first time, which means that once the partial pressure of oxygen diminishes to certain degree, vessel in different tissues reacts via the reactive oxygen species (ROS)-potassium channels (Kv)-hypoxia inducible factors (HIF) triangle, resulting in hypoxic vasoconstriction and vascular remodeling. HRT, varying according to different parts of the body, has close relationship with normoxic condition of the vessels. Physiological oxygen-rich milieu determines higher pulmonary vascular HRT, which explains why the pulmonary arterioles are more susceptible to hypoxia.
      Graphical abstract image

      PubDate: 2015-02-18T12:49:05Z
      DOI: 10.1016/j.jmhi.2015.01.002
      Issue No: Vol. 9, No. 1 (2015)
       
  • Antibody against α-gliadin 33-mer peptide: Is the key initiating factor
           for development of multiple sclerosis during gluten sensitivity'

    • Authors: Aram Mokarizadeh; Parisa Esmaeili; Hamid Soraya; Kambiz Hassanzadeh; Ali Jalili; Mohammad Abdi; Mohammad Reza Faryabi
      Pages: 38 - 44
      Abstract: Publication date: March 2015
      Source:Journal of Medical Hypotheses and Ideas, Volume 9, Issue 1
      Author(s): Aram Mokarizadeh , Parisa Esmaeili , Hamid Soraya , Kambiz Hassanzadeh , Ali Jalili , Mohammad Abdi , Mohammad Reza Faryabi
      Despite great advances in clarifying the pathogenesis of multiple sclerosis (MS), the exact underlying mechanism has not been definitely established. However, the responsibility of cross-reactive antibodies as the initiating factor in MS pathogenesis is a novel idea. Recently, an antibody against-α-gliadin 33-mer peptide which is found in most patients with gluten sensitivity have shown to cross-react significantly with various neural antigens including asialoganglioside, synapsin, and myelin basic protein (MBP). Furthermore, evidence indicates that IL-17, circulating immune complexes and even antibodies produced during gluten sensitivity can contribute to blood–brain barrier (BBB) permeability. Accordingly, extravasation of these anti-α-gliadin antibodies (AGA; especially IgG isotype) through the impaired BBB thought to target asialoganglioside, synapsin, and MBP in neurons. This opsonization may trigger a series of cascade pathways including complement activation, antibody-dependent microglial cytotoxicity against neurons, secretion of inflammatory mediators, myelin sheath damage, chemokine expression, CNS inflammation, BBB disruption and then leukocyte infiltration. The present hypothesis introduces a new antibody-dependent alternative pathway which may lead to multiple sclerosis (MS) during gluten sensitivity.
      Graphical abstract image

      PubDate: 2015-04-04T14:06:21Z
      DOI: 10.1016/j.jmhi.2015.02.002
      Issue No: Vol. 9, No. 1 (2015)
       
  • Functional representation of vision within the mind: A visual
           consciousness model based in 3D default space

    • Authors: Ravinder Jerath; Molly W. Crawford; Vernon A. Barnes
      Pages: 45 - 56
      Abstract: Publication date: Available online 9 March 2015
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Ravinder Jerath , Molly W. Crawford , Vernon A. Barnes
      The human eyes and brain, which have finite boundaries, create a “virtual” space within our central nervous system that interprets and perceives a space that appears boundless and infinite. Using insights from studies on the visual system, we propose a novel fast processing mechanism involving the eyes, visual pathways, and cortex where external vision is imperceptibly processed in our brain in real time creating an internal representation of external space that appears as an external view. We introduce the existence of a three-dimension default space consisting of intrapersonal body space that serves as the framework where visual and non-visual sensory information is sensed and experienced. We propose that the thalamus integrates processed information from corticothalamic feedback loops and fills-in the neural component of 3D default space with an internal visual representation of external space, leading to the experience of visual consciousness. This visual space inherently evades perception so we have introduced three easy clinical tests that can assist in experiencing this visual space. We also review visual neuroanatomical pathways, binocular vision, neurological disorders, and visual phenomenon to elucidate how the representation of external visible space is recreated within the mind.
      Graphical abstract image

      PubDate: 2015-03-10T20:24:50Z
      DOI: 10.1016/j.jmhi.2015.02.001
      Issue No: Vol. 9, No. 1 (2015)
       
  • The progression of cancer and metastasis formation: an epigenetic
           hypothesis

    • Abstract: Publication date: Available online 30 January 2015
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): R. Alelú-Paz
      The molecular mechanisms of tumor metastasis remain largely unknown and undefined. A recent model suggests that a minor population of cells (cancer stem cells) is programmed to preferentially metastasize to specific organs based on their gene expression patterns. These cells have the ability to generate tumors after implantation into animal hosts, to self-renew and give rise to non-stem cells. In this paper I hypothesize that epigenetic mechanisms could play an important role in tumor metastasis through the reorganization of the bivalent chromatin marks in cancer stem cells in three phases: 1) the reprogramming of epigenetic marks in differentiation master regulator genes responsible for the differentiation to one particular lineage 2) the resolution of these bivalent chromatin marks forces cells to develop the necessary mechanisms to migrate to a new niche and 3) the epigenetic activation of the tissue-specific genes associated with the specific target organ and, simultaneously, the repression of genes associated with alternative developmental pathways.
      Graphical abstract image

      PubDate: 2015-02-02T10:46:37Z
       
  • A comparison of downloads, readership and citations data for the Journal
           of Medical Hypotheses and Ideas

    • Authors: Azam Bazrafshan; Ali Akbar Haghdoost; Morteza Zare
      Pages: 1 - 4
      Abstract: Publication date: March 2015
      Source:Journal of Medical Hypotheses and Ideas, Volume 9, Issue 1
      Author(s): Azam Bazrafshan , Ali Akbar Haghdoost , Morteza Zare
      This article reflects the comparison of downloads, readership and citation data for the Journal of Medical Hypotheses and Ideas. A brief analysis of the journal’s recent performance indicates that the journal articles appear to have a high rate of downloads around the world. Its published articles are from a variety of countries and the odds of accepted articles for publication is surprisingly even across regions. However, the rate of received citations to the published articles indicated a lack of considerable impact in scholarly publications. This approach has double value as it shows the overall impact of the journal in social web as well as scholarly publications and also provides future directions for the journal’s editorial boards. Altmetrics was also proposed as an alternative to the widely used citation and usage indicators in tracking the impact of individual articles.
      Graphical abstract image Highlights

      PubDate: 2014-07-27T07:05:27Z
      DOI: 10.1016/j.jmhi.2014.06.001
      Issue No: Vol. 9, No. 1 (2014)
       
  • Injection of botulinum toxin A in lateral pterygoid muscle as a novel
           method for prevention of traumatic temporomandibular joint ankylosis

    • Authors: Jiewen Dai; Hongbo Yu; Min Zhu; Steve Guofang Shen
      Pages: 5 - 8
      Abstract: Publication date: March 2015
      Source:Journal of Medical Hypotheses and Ideas, Volume 9, Issue 1
      Author(s): Jiewen Dai , Hongbo Yu , Min Zhu , Steve Guofang Shen
      Temporomandibular joint (TMJ) ankylosis can restrict the mandibular movement, followed by resulting in numerous problems. To understand the mechanism of TMJ ankylosis (TMJA) and prevent the generation of TMJA is urgent necessary. Although many factors contribute to it, trauma is the most common cause of TMJA. The mechanisms of TMJA are still unclear, and the distraction osteogenesis of the lateral pterygoid muscle (LPM) may play an important role. Injection of very small amounts of botulinum toxin type A (BTA) can temporarily block the muscle’s impulse and has been revealed to be an effective treatment method for many temporomandibular disorders. In this article, we make a hypothesis that LPM injection of BTA as a novel method for immobilization of mandible, followed by preventing the traumatic TMJA. Furthermore, the side effects of local injection of BTA also are minimal, temporary, reversible and self-limiting. If this strategy is validated, LPM injection of BTA will be a cost effective way to be administrated to prevent the traumatic TMJA.
      Graphical abstract image Highlights

      PubDate: 2014-07-27T07:05:27Z
      DOI: 10.1016/j.jmhi.2014.06.002
      Issue No: Vol. 9, No. 1 (2014)
       
  • Beta-amyloid exhibits antagonistic effects on alpha 7 nicotinic
           acetylcholine receptors in orchestrated manner

    • Authors: Saeed Sadigh-Eteghad; Mahnaz Talebi; Mehdi Farhoudi; Samad E.J. Golzari; Babak Sabermarouf; Javad Mahmoudi
      Pages: 49 - 52
      Abstract: Publication date: Available online 12 February 2014
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Saeed Sadigh-Eteghad , Mahnaz Talebi , Mehdi Farhoudi , Samad E.J. Golzari , Babak Sabermarouf , Javad Mahmoudi
      Although beta-amyloid (Aβ) has been regarded as the principal toxic factor in the pathogenesis of Alzheimer’s disease (AD), it plays important physiological roles in such phenomena as neuron survival, synaptic plasticity and memory formation. There are numerous plausible reasons to assume that all of the mentioned pathological and physiological functions of Aβ may be partially mediated via alpha 7 nicotinic acetylcholine receptor (nAChR). Agonistic and antagonistic aspects of Aβ on nAChRs may explain this paradox in peptide – receptor function. It seems that Aβ shows antagonistic effects on α7 nAChR in a dose-dependent manner, and its pathologic function may partially correlate with antagonization of the receptor. If this hypothesis is supported, the related mechanisms of neurotoxicity, neuroprotection, memory formation and AD pathogenesis might be identified. In addition, such knowledge helps make more valid interpretation of neuron signaling and better design of AD animal models. Also, it may provide new insights into AD therapy development via reducing the amount of Aβ and inhibition of peptide aggregation.

      PubDate: 2014-02-12T17:24:35Z
      DOI: 10.1016/j.jmhi.2014.01.001
      Issue No: Vol. 8, No. 2 (2014)
       
  • Combination of IMOD™ and Arbidol to increase their immunomodulatory
           effects as a novel medicine to prevent and cure influenza and some other
           infectious diseases

    • Authors: Mahmoud Arastoo; Hamid Reza Khorram Khorshid; Ramin Radmanesh; Farhad Gharibdoust
      Pages: 53 - 56
      Abstract: Publication date: Available online 28 February 2014
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Mahmoud Arastoo , Hamid Reza Khorram Khorshid , Ramin Radmanesh , Farhad Gharibdoust
      Viral diseases such as influenza which are easily transferable from person to person or even country to country pose one of the biggest threats to today’s health. Viruses such as avian influenza viruses (N1H5 and H9N1) have been reported to spread in the present decade and very recently, the novel coronavirus that has caused many life threatening illnesses and deaths all around the world has received much attention. To prevent these highly contagious viral infections, we have proposed the combination of IMODTM and Arbidol to increase their immunomodulatory effects as a novel medicine to prevent and cure influenza and some other infectious diseases such as hepatitis B and C. On one hand, IMODTM within the last few years has been proven to safely and effectively increase the life expectancy for HIV infected individuals by increasing CD4 lymphocytes. On the other hand, Arbidol, an anti-viral agent has been used safely and effectively in the last two decades to prevent and cure all types of influenza and flu. Therefore, the combination of both in a single dosage to further increase CD4 lymphocytes and interferon gamma (IFN-γ) could be a better choice for treatment of viral infections. This proposal tries to provide enough support and background for approval of a randomized clinical trial by the relevant team of investigators.

      PubDate: 2014-03-04T17:16:11Z
      DOI: 10.1016/j.jmhi.2014.02.001
      Issue No: Vol. 8, No. 2 (2014)
       
  • Science for the benefits of all; The way from idea to product

    • Authors: Faheem Maqbool; Haji Bahadar; Mohammad Abdollahi
      Pages: 74 - 77
      Abstract: Publication date: Available online 26 February 2014
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Faheem Maqbool , Haji Bahadar , Mohammad Abdollahi
      Science is a knowledge based on hypotheses, observations, and experiments. From its very beginning science has served the humanity and will continue to do so until the needs of human being are fulfilled. History is rich of many scientists who have contributed to different fields of science free of politics, religion, cast, and region. Every human being must have the right to use science and technology for beneficial purposes. Mutual coordination between academia and industries is extremely important for the growth of science. The spread of ideas is only possible with publication and distribution of information to all in the world. Unpublished new ideas will remain hidden. With no doubt, many of publications and products get the spirit from the very first ideas. It is necessary that all scientists share their ideas, opening new opportunities for others to work in the various aspects them. We are of the view that, to find a solution to our problems or satisfy human needs, it is important to ponder new ways in science, generate new ideas and share with others, so the concept of “science for the benefits of all” remain alive forever.
      Graphical abstract image Highlights

      PubDate: 2014-02-26T19:25:40Z
      DOI: 10.1016/j.jmhi.2014.02.002
      Issue No: Vol. 8, No. 2 (2014)
       
  • Constructing a 3D-printable, bioceramic sheathed articular spacer assembly
           for infected hip arthroplasty

    • Authors: Yuan Zhang; Jie Zhu Zhibing Wang Yue Zhou Xia Zhang
      Abstract: Publication date: Available online 15 December 2014
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Yuan Zhang , Jie Zhu , Zhibing Wang , Yue Zhou , Xia Zhang
      Total hip arthroplasty (THA) has progressed to be one of the most cost-effective surgical procedures to relieve pain and restore function to the pathological hip. Official retrospective statistics revealed over 500,000 cases of THA were performed per annum in the US alone, but failure cases brought about more than 40,000 revision procedures among them. The revision surgery is usually hard to manipulate due to the formidable difficulty of repairing the critical bone defect. Plenty of attempts aiming at tackling this problem have been dedicated by both tissue engineering and clinical investigators. Despite of the initial success, it is still a great challenge to overcome atypical intertrochanteric and diaphyseal defects of proximal femur to reach a satisfied therapeutic outcome in terms of long-term survivorship of the prosthesis. Given the interdisciplinary integration of biomaterial fabrication, bone tissue engineering, rapid prototyping, and biomacromolecule/drug delivery, we propose a hypothesis to construct a biphasic articular spacer to reach the dual goal of infection control and bone regeneration in this study. To be specific, this complex is consisted by a geometry-specific calcium phosphate sheath, derived from computer aided design and low temperature 3D printing, and an axial bone cement pillar delivering antibiotics. Theoretically, this modularized spacer possesses the potency of enhanced osteogenesis, controlled release of specific drugs, and co-delivery of growth factors. If this strategy is validated, further effort can be made to strengthen the printability of calcium phosphate using the 3D printing technique, and to accelerate its translation from lab to clinics.
      Graphical abstract image

      PubDate: 2014-12-18T09:21:59Z
       
  • Transdermal bFGF delivery using low-frequency sonophoresis: an innovative
           potential therapy for osteoradionecrosis of jaws

    • Authors: Zhihui Zhou; Weiwei Fan Miaojie Lang Yanliang Wang
      Abstract: Publication date: Available online 6 October 2014
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Zhihui Zhou , Weiwei Fan , Miaojie Lang , Yanliang Wang
      Osteoradionecrosis of jaws (ORNJ) is a serious complication of radiotherapy for patients with head and neck cancer. As of yet, no universally accepted treatment exists for this chronic pathologic condition. It has been shown that ultrasound is an effective, non-invasive adjunctive therapy in ORNJ, as ultrasound can result in the increase of angiogenesis and bone production, which are essential for ORNJ healing. Recently, low-frequency ultrasound has been demonstrated to enhance transdermal delivery of macromolecules and hydrophilic drugs (low-frequency sonophoresis, LFS). As a biological macromolecule, basic fibroblast growth factor (bFGF) also has potential osteoinductive and angiogenic properties. Herein, we present a hypothesis that LFS-mediated transdermal bFGF delivery is capable of improving the healing of ORNJ and will be a new effective adjunctive therapy to surgery. This treatment combines low-frequency ultrasound with bFGF to respectively promote vascularly compromised bone and soft tissue wound healing, and is expected to be more effective than ultrasound therapy alone.
      Graphical abstract image

      PubDate: 2014-10-08T08:30:46Z
       
  • IL-24: A Novel Gene Therapy Candidate For Immune System Up-Regulation in
           Hodgkin’s Lymphoma

    • Authors: Maryam Erfan; Manesh Abdolreza Esmaeilzadeh Mehri Hajikhan Mirzaei
      Abstract: Publication date: Available online 24 May 2014
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Maryam Erfan Manesh , Abdolreza Esmaeilzadeh , Mehri Hajikhan Mirzaei
      Hodgkin Lymphoma (HL) as a prevalent hematolymphoid malignancy begins in cells of immune system and is characterized by the specific histologic, clinical properties. Abnormality in apoptosis has been recognized as a crucial pathway in its progression. Nowadays, 35% to 40% of patients in stages III and IV, show disease relapse or symptoms of refractory to first-line chemotherapy, it seems that novel treatment strategies are needed to find. Since apoptosis inducing is an important mechanism in cancer treatments, novel anti cancer molecules to induce programmed cell death are required. The authors present a novel therapeutic approach for HL, regards to anti-tumoral and immunomodulatory effects of the mda-7/IL-24. This gene, located in human chromosome 1q32-33, has shown tumor suppressor activity in various human malignant cells in, in vitro, in vivo and even in clinical trial studies. Our hypothesis, was designed to evaluate anti tumoral effects of mda-7/IL-24 in SCID mice model using the adenovirus-based vector. mda-7/IL-24 intrestingly, has antiangiogenic, immunomodulatory and bystander antitumoral activities. mda-7/IL-24 can suppress anti-apoptotic Bcl-2 family proteins, and induces GADD family, Bak, Bax and other pro-apoptosis proteins. This hypothesis suggests that adenovirus vectors expressing mda-7/IL-24 may help for an effective immunotherapies of HL.
      Graphical abstract image Highlights

      PubDate: 2014-05-25T06:16:23Z
       
  • Blocking IRES-mediated Translation Pathway as A New Method to Treat
           Alzheimer’s Disease

    • Authors: Q.Y. Liu
      Abstract: Publication date: Available online 14 May 2014
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Q.Y. Liu
      Scientists theorized that β-amyloid plaques and tau tangles are required for Alzheimer’s disease (AD), and amyloid precursor protein (APP) produce β-amyloid (Aβ) to trigger disease process. However, the normal synaptic function of APP itself is not fully understood. Several findings cast APP as a potential key player in learning and memory under normal condition but disrupted by abnormal accumulation of Aβ under cellular pathological conditions. Herein, there is a hypothesis that AD could be treated by attenuating APP synthesis during cellular pathophysiological stress. In virtue of previous study, it was speculated that cell could not decrease APP synthesis via self-protection maybe because APP synthesizes with internal ribosome entry segment (IRES)-mediated translation. Consequently, the blockage of this translation manner might be a new inoffensive and high-level specificity treatment.
      Graphical abstract image Highlights

      PubDate: 2014-05-14T16:20:31Z
       
  • Using Three-Dimensional Porous Internal Titanium scaffold or Allogenic
           Bone Scaffold for Tissue-engineering Condyle as a Novel Reconstruction of
           mandibular Condylar Defects

    • Abstract: Publication date: Available online 6 December 2013
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Chang-Kui Liu , Cai-xia Jing , Xin-Ying Tan , Juan Xu , Min Hu
      Mandibular destruction resulting from tumors, trauma, congenital, ankylosis and other reasons, leads to disturbed masticatory function. The ideal goal would be to reconstruct a condyle that is similar to the original. However, each of condylar reconstruction approaches in current has specific shortcomings. Tissue engineering can provide a method to overcome these difficulties. Tissue-engineer mandibular condyle composing bone and cartilage has been reported, but the strength and shape of the scaffolds they used can not meet the requirement of the clinical use. Freeze-dried allogenic condylar bone is biocompatible, bioresorbable of low antigenicity and provides the morphology for condyle similar to the original. It is a good scaffold material for tissue-engineering. The three-dimensional porous internal titanium scaffold is also biocompatible, it can be easy to made into the shape that we needed. The two scaffolds have sufficient mechanical strength before no bone formation. So we hypothesize using three-dimensional porous titanium scaffold or allogenic bone scaffold combined with osteogenic, chondrogenic material and bone marrow stromal stem cells in vivo tissue engineering to repair condylar defects. This article is about the hypotheses.
      Graphical abstract image Highlights

      PubDate: 2013-12-10T03:36:13Z
       
  • Mobile phone radiofrequency radiation, is it really bad' is there any
           evidence'

    • Abstract: Publication date: Available online 23 November 2013
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Viroj Wiwanitkit


      PubDate: 2013-11-24T07:54:06Z
       
  • The possible role of peripherally generated cross-reactive IgG in break
           -down of the blood-brain barrier and initiation of multiple sclerosis

    • Abstract: Publication date: Available online 23 November 2013
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Aram Mokarizadeh , Mohammad Abdollahi , Mohammad-Amin Rezvanfar , Mohammad- Reza Rahmani
      The initiating event in multiple sclerosis (MS) pathogenesis has not known yet. However, in general, break down of blood-brain barrier (BBB) and subsequently infiltration of immune cells into central nervous system (CNS) has thought to be the main initiating event. Nonetheless, the mechanism by which BBB gets disrupted and allows immune cells to infiltrate into CNS is not fully understood. There are evidences indicate that prior to cellular infiltration, over passing of peripherally generated cross-reactive IgG through the transiently permeable BBB during systemic inflammation, hypoxia, hyperthermia, transient hypertension or acute stresses may cause to CNS inflammation, BBB break down and then initiation of MS disease. Here, we discuss the possible detailed mechanisms may involve in cross-reactive IgG-mediated MS autoimmunity.
      Graphical abstract image Highlights

      PubDate: 2013-11-24T07:54:06Z
       
  • Vascular Endothelial Growth Factor Blockade: a potential new therapy in
           the management of Cerebral Arteriovenous Malformations

    • Abstract: Publication date: Available online 11 November 2013
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Frederik Jozef Alfons Ivan Vernimmen
      Cerebral Arteriovenous Malformations (AVM) occurs universally in 1.1 per 100000 people. They are the cause of serious neurological morbidity or even death when they bleed. AVM’s are not necessarily static congenital abnormalities. They can undergo internal changes due to angiogenesis resulting in vascular remodelling. They can even re-grow after successful therapy. Vascular endothelial growth factors (VEGF) play an important role in angiogenesis. Drugs are available that block the action of VEGF on VEGFR receptors on the endothelial cell surface. This blockade causes an anti-angiogenetic effect. Anti-angiogenic drugs are widely used as adjuvant therapy in the management of cancers because they suppress the formation of new blood vessels required by the tumour for growth. For similar reasons they are used in the treatment of age related macular degeneration. The present treatment options for AVM’s are surgery, embolization and irradiation either on their own or in combination. Irradiation with Stereotactic Radiosurgery (SRS) offers the advantage of being non invasive, but relies on the late radiation effects to achieve its therapeutic goal of complete obliteration. This latent time (1 – 3 years) during which the risk for a bleed remains is an inherent drawback of SRS. The histopathology of surgical specimens of post SRS AVM’s demonstrates a role of endothelial cells in repairing the radiation damage. Suppressing their activity post SRS by a VEGF Blockade has the potential to enhance the radiation damage and hence speed up the obliteration process and reduce the latent time. It is postulated that such a “VEGF Blockade” could be useful as an adjuvant therapy to SRS. In addition there is also the potential for a neo adjuvant use, whereby a VEGF blockade could cause regression in the size of the AVM, making definite therapy easier. The rationale for the VEGF-blockade concept will be presented and discussed.
      Graphical abstract image

      PubDate: 2013-11-15T15:26:01Z
       
  • A novel device for extracting chyme from gastric cavity

    • Abstract: Publication date: Available online 15 August 2013
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Ai-Juan Shen , Hai-Lin Zhu , Jian-Hua Duan , Min Zou , Ying Jiang
      Negative pressure drainage (NPD) technology is required to extract chyme from the gastric cavity of the patient suffering from stomach disease in order to observe the mucosal condition of the gastric cavity clearly and to avoid being misdiagnosed in gastroscopy. However, there are problems, such as insufficient vacuum and easy clogging, in the current NPD devices. To deal with these problems, by applying the principle of hydraulic check valve, a novel device, convenient to extract chyme from gastric cavity, is discussed in this article, which will meet the clinical demand. The proposed new device has the advantages of enough vacuum degree, smooth drainage without backflow and blockage, and has a better application prospect as compared to existing devices.
      Graphical abstract image

      PubDate: 2013-10-07T16:16:14Z
       
  • Human endometrial adult stem cells can be differentiated into hepatocyte
           cells

    • Abstract: Publication date: Available online 6 August 2013
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Farzaneh Khademi , Javad Verdi , Masoud Soleimani , Reza Roozafzoon , Saeed Heidari Keshel , Reza Raeisossadati , Jafar Ai
      Liver transplantation is the only choice for patients with end-stage liver diseases. Hepatocyte transplantation is a promising alternative for treatment of these groups. However, the major challenge is insufficiency of donor organs that can provide good-quality cells. Therefore, numerous experimental and clinical studies have evaluated the potential of different sources of adult stem cells, which differentiate into hepatocytes, for cell therapy. Endometrial (stem) stromal cells are readily isolated and expandable; moreover, these cells have more clonogenicity and pose less technical problems, so they are considered to possess great autologous therapeutic potential. We propose that endometrial stem (stromal) cells could be an invaluable and realistic source in this regard.
      Graphical abstract image

      PubDate: 2013-10-07T16:16:14Z
       
  • Repair of spinal cord injury by hypoxia-inducible factor-1a-expressing
           neural stem cells

    • Abstract: Publication date: Available online 3 August 2013
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Lei Wang , Da Duan , Zhenyu Zhao , Xiaohua Teng , Lite Ge , Bin Liu , Ming Lu
      Neural stem cell (NSC) transplantation is an effective method of giving a supplement of cells lost and promoting functional recovery after spinal cord injury (SCI). Nonetheless, owing to hostile environments at the injury site, such as ischaemic hypoxia conditions and inflammatory cytokines, poor cell survival and uncontrolled differentiation are consistent problems encountered following NSC transplantation in ischaemic neural tissue. Hypoxia-inducible factor-1a (HIF-1α) provides profound protection to NSCs against negative factors at the injury site. On the other hand, HIF-1 can induce NSCs to differentiate into neurons. We predict that transplanted NSCs modified by an HIF-1α gene would have a better efficacy for promoting neural regeneration and functional reconstruction.
      Graphical abstract image

      PubDate: 2013-10-07T16:16:14Z
       
  • Fibroblast growth factor-21 may be a potential novel drug for preventing
           the development of traumatic TMJ bony ankylosis

    • Abstract: Publication date: Available online 3 August 2013
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Su-Xia Liang , Ying-Bin Yan
      Trauma is the leading cause of temporomandibular joint (TMJ) bony ankylosis. The treatment of the condition poses a significant challenge because of the high incidence of recurrence. We previously proposed a new view that the development of traumatic TMJ bony ankylosis may be a course similar to hypertrophic nonunion, and the ensuing animal experiments preliminarily verified this view through histological analysis and molecular biology examination. In view of the similarity between bone healing and bony ankylosis, and the importance of recruitment and differentiation of mesenchymal stem cells (MSCs) during the course of bone healing, it is reasonable to select MSCs as the breakthrough point for prevention of bony ankylosis. Recent studies reveal that fibroblast growth factor 21 (FGF21), a key mediator of peroxisome proliferator-activated receptor-γ (PPARγ), can promote adipocyte differentiation, inhibit osteoblast differentiation of MSCs and stimulate osteoclast activity by activation of PPARγ. Therefore, we hypothesize that local FGF21 injection may prohibit the onset of traumatic TMJ bony ankylosis through formation of a fat pad separating the condyle from the glenoid fossa, inhibition of new bone formation and promotion of bone resorption in the joint space, which thus may be a potential novel treatment for TMJ bony ankylosis.
      Graphical abstract image

      PubDate: 2013-10-07T16:16:14Z
       
  • Simple and accessible screening method for congenital thrombopathies using
           an impedance haematology counter – reply: The differences between
           impedance aggregometry in whole blood versus aggregometry in PRP. Is there
           a need for caution'

    • Abstract: Publication date: Available online 22 July 2013
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Ingrid Skornova , Jan Stasko , Amalia Ocenasova , Peter Kubisz
      Brahimi et al. in this journal formed a hypothesis that “the platelet count is underestimated, by an automated cell counter, each time platelet aggregates are present in the sample tube.” The addition of a platelet agonist to a stimulated sample tube will lead to the formation of platelet aggregates and hence to a drop in the platelet count. In the case of a hereditary platelet dysfunction, platelet aggregates cannot be formed upon addition of a platelet agonist and the platelet count will remain unchanged. The authors propose a hypothesis to develop “a more accessible screening technique for these hereditary platelet dysfunctions.” In our reply, we critically evaluate this screening method and focus on the importance of the differences between impedance aggregometry in whole blood versus aggregometry in platelet-rich plasma.
      Graphical abstract image

      PubDate: 2013-10-07T16:16:14Z
       
  • Overexpression of MDA-7/IL-24 as an anticancer cytokine in gene therapy of
           thyroid carcinoma

    • Abstract: Publication date: Available online 1 July 2013
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Mehri Hajikhan Mirzaei , Abdolreza Esmaeilzadeh
      The annual incidence of thyroid cancer worldwide is alarming. Despite current various treatments such as surgical resection, radioiodine therapy and chemotherapy/radiotherapy, thyroid carcinoma remains a lethal cancer. Assuredly, the operative and new treatment strategies are necessary to control this malignancy. Gene therapy is regarded as one of the most reliable novel therapeutic methods for hopeless cases of thyroid cancer and those who do not respond to the prevalent treatments. Accumulated evidence suggests that interleukin-24 (IL-24), also known as melanoma differentiation-associated gene-7, has very important roles in regulation of cell differentiation, cell growth and apoptosis, and it is also a promising anticancer agent. Here, we propose that it could be advantageous to evaluate the anti-tumoural effect of IL-24 in a mouse xenograft model of thyroid cancer.
      Graphical abstract image

      PubDate: 2013-10-07T16:16:14Z
       
  • Antiangiogenic effect of silicate nanoparticles on corneal
           neo-vascularisation induced by vascular endothelial growth factor

    • Abstract: Publication date: Available online 25 June 2013
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): Mehrdad Mohammadpour , Mahmoud Jabbarvand , Elham Delrish , Ahad Khoshzaban
      Corneal neo-vascularisation (NV) is a major sight-threatening condition and is caused by infections, degenerative disorders, inflammation and long-time contact lens wear. Corneal NV occurs when the balance between angiogenic and antiangiogenic factors is tipped towards angiogenic molecules. The abnormal vessels may decrease corneal clarity and vision, lead to inflammation and corneal scarring and worsen the prognosis of penetrating keratoplasty if needed. There is no definite therapeutic approach for cornea NV. Medical and surgical therapies used to reduce corneal NV include corticosteroids and non-steroidal anti-inflammatory agents, laser photocoagulation and needle diathermy. Many of these therapies not only have demonstrated limited success but also have associated adverse effects. Therefore, it is very necessary to provide novel therapeutic approaches. Recently, anti-vascular endothelial growth factor (anti-VGEF) therapy has been introduced for the management of corneal NV. Herein, we hypothesise the use of silicate nanoparticles (SiNPs) as a novel treatment for corneal NV. The penetration rate of SiNPs into the cornea is attributed to the size of nanoparticles. Therefore, different sizes of SiNPs (20–50nm) would be prepared and loaded onto the tissue to determine corneal permeability towards them. In addition, SiNPs would be administered into the eye by topical, subconjunctival and corneal intrastromal injection and accumulate in newly formed vessels. This hypothesis has been developed by emphasising on the synthesis of SiNPs, characterisation of size-dependent properties and surface modification for the preparation of homogeneous nanocomposites, generated by a reverse micro-emulsion method. As the importance of concentration, shape and/or size of SiNPs could be key factors exerting their antiangiogenic effects, we suggest using 20–30-nm SiNPs to enhance their ability to penetrate into the corneal epithelium. We hypothesise that topical, subconjunctival and corneal intrastromal injections of SiNPs may effectively inhibit and treat corneal NV. Controlled experimental studies on rabbits are needed to test whether SiNPs are able to effectively inhibit VEGF-induced angiogenesis in every segment of the eye including anterior, middle (ciliary body and trabecular mesh work) and posterior segments.
      Graphical abstract image

      PubDate: 2013-10-07T16:16:14Z
       
  • Role of various flavonoids: Hypotheses on novel approach to treat diabetes

    • Abstract: Publication date: Available online 22 June 2013
      Source:Journal of Medical Hypotheses and Ideas
      Author(s): S. Mohan , L. Nandhakumar
      Basically flavonoids are naturally occurring phenolic compounds that are distributed in plants. They contain wide range of biological activity and lot of research has been carried out on their potential role in treating diabetes and other diseases. Most importantly the flavonoids and their related natural compounds are known to encompass antidiabetic potential, demonstrated in various animal models. Such beneficial flavonoids are less utilized on account of its deprived solubility, decreased bioavailability; first pass metabolism and intestinal degradation. However, flavonoids are capable of improving, stabilizing and long sustaining the insulin secretion, human islets and pancreatic cell respectively. In this article we propose, remarkable antidiabetic activity of flavonoids as well as few approaches on nanoparticulate systems in diabetes induced animal models. The proposed nanoparticulate system of flavonoids is projected to improve the solubility, bioavailability, by passing the first pass metabolism and decreasing susceptibility to intestinal environment as compared to pure flavonoid isolates. Further, this hypothesis exemplifies to enhance the efficacy of flavonoids in a novel way of antidiabetic treatment.
      Graphical abstract image

      PubDate: 2013-10-07T16:16:14Z
       
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


Your IP address: 3.237.71.23
 
Home (Search)
API
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-