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  Subjects -> MEDICAL SCIENCES (Total: 7268 journals)
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MEDICAL SCIENCES (1810 journals)                  1 2 3 4 5 6 7 8 | Last

Showing 1 - 200 of 3562 Journals sorted alphabetically
16 de Abril     Open Access  
AADE in Practice     Hybrid Journal   (Followers: 4)
ABCS Health Sciences     Open Access   (Followers: 1)
Abia State University Medical Students' Association Journal     Full-text available via subscription  
ACIMED     Open Access   (Followers: 1)
ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 39)
Acta Bio Medica     Full-text available via subscription   (Followers: 2)
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Acta Bioquimica Clinica Latinoamericana     Open Access   (Followers: 1)
Acta Facultatis Medicae Naissensis     Open Access  
Acta Informatica Medica     Open Access   (Followers: 1)
Acta Medica Bulgarica     Open Access  
Acta Medica Colombiana     Open Access   (Followers: 1)
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Acta Medica Indonesiana     Open Access  
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Acta Scientiarum. Health Sciences     Open Access  
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 2)
Addiction Science & Clinical Practice     Open Access   (Followers: 7)
Addictive Behaviors Reports     Open Access   (Followers: 5)
Advanced Health Care Technologies     Open Access   (Followers: 4)
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Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20)
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Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5)
Advances in Wound Care     Hybrid Journal   (Followers: 10)
African Health Sciences     Open Access   (Followers: 2)
African Journal of Biomedical Research     Open Access  
African Journal of Clinical and Experimental Microbiology     Open Access   (Followers: 1)
African Journal of Laboratory Medicine     Open Access   (Followers: 2)
African Journal of Medical and Health Sciences     Open Access   (Followers: 1)
African Journal of Trauma     Open Access  
Afrimedic Journal     Open Access   (Followers: 2)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 8)
AJOB Primary Research     Partially Free   (Followers: 3)
Aktuelle Ernährungsmedizin     Hybrid Journal   (Followers: 4)
Al-Azhar Assiut Medical Journal     Open Access  
Alexandria Journal of Medicine     Open Access  
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 2)
Alpha Omegan     Full-text available via subscription  
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 3)
American Journal of Biomedical Engineering     Open Access   (Followers: 11)
American Journal of Biomedical Research     Open Access   (Followers: 2)
American Journal of Biomedicine     Full-text available via subscription   (Followers: 6)
American Journal of Chinese Medicine, The     Hybrid Journal   (Followers: 5)
American Journal of Clinical Medicine Research     Open Access   (Followers: 6)
American Journal of Family Therapy     Hybrid Journal   (Followers: 11)
American Journal of Law & Medicine     Full-text available via subscription   (Followers: 13)
American Journal of Lifestyle Medicine     Hybrid Journal   (Followers: 5)
American Journal of Managed Care     Full-text available via subscription   (Followers: 11)
American Journal of Medical Case Reports     Open Access   (Followers: 1)
American Journal of Medical Sciences and Medicine     Open Access   (Followers: 1)
American Journal of Medicine     Hybrid Journal   (Followers: 45)
American Journal of Medicine and Medical Sciences     Open Access   (Followers: 1)
American Journal of Medicine Studies     Open Access  
American Journal of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American Journal of the Medical Sciences     Hybrid Journal   (Followers: 12)
American Journal on Addictions     Hybrid Journal   (Followers: 9)
American Medical Journal     Open Access   (Followers: 4)
American medical news     Free   (Followers: 3)
American Medical Writers Association Journal     Full-text available via subscription   (Followers: 2)
Amyloid: The Journal of Protein Folding Disorders     Hybrid Journal   (Followers: 4)
Anales de la Facultad de Medicina     Open Access  
Anales de la Facultad de Medicina, Universidad de la República, Uruguay     Open Access  
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1)
Analgesia & Resuscitation : Current Research     Hybrid Journal   (Followers: 2)
Anatomical Science International     Hybrid Journal   (Followers: 2)
Anatomical Sciences Education     Hybrid Journal   (Followers: 1)
Anatomy Research International     Open Access   (Followers: 2)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3)
Annales de Pathologie     Full-text available via subscription  
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 3)
Annals of African Medicine     Open Access   (Followers: 1)
Annals of Anatomy - Anatomischer Anzeiger     Hybrid Journal   (Followers: 2)
Annals of Bioanthropology     Open Access   (Followers: 3)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18)
Annals of Biomedical Sciences     Full-text available via subscription   (Followers: 3)
Annals of Clinical Microbiology and Antimicrobials     Open Access   (Followers: 8)
Annals of Family Medicine     Open Access   (Followers: 13)
Annals of Fundeni Hospital     Open Access   (Followers: 1)
Annals of Ibadan Postgraduate Medicine     Open Access  
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Medicine     Hybrid Journal   (Followers: 11)
Annals of Medicine and Surgery     Open Access   (Followers: 5)
Annals of Microbiology     Hybrid Journal   (Followers: 10)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Saudi Medicine     Open Access  
Annals of the New York Academy of Sciences     Hybrid Journal   (Followers: 5)
Annals of The Royal College of Surgeons of England     Full-text available via subscription   (Followers: 3)
Annual Reports in Medicinal Chemistry     Full-text available via subscription   (Followers: 7)
Annual Reports on NMR Spectroscopy     Full-text available via subscription   (Followers: 4)
Annual Review of Medicine     Full-text available via subscription   (Followers: 18)
Anthropological Review     Open Access   (Followers: 24)
Anthropologie et santé     Open Access   (Followers: 5)
Antibiotics     Open Access   (Followers: 9)
Antibodies     Open Access   (Followers: 2)
Antibody Technology Journal     Open Access   (Followers: 1)
Anuradhapura Medical Journal     Open Access  
Anwer Khan Modern Medical College Journal     Open Access   (Followers: 2)
Apmis     Hybrid Journal   (Followers: 1)
Apparence(s)     Open Access   (Followers: 1)
Applied Clinical Informatics     Hybrid Journal   (Followers: 2)
Applied Medical Informatics     Open Access   (Followers: 11)
Arab Journal of Nephrology and Transplantation     Open Access   (Followers: 1)
Arak Medical University Journal     Open Access  
Archive of Clinical Medicine     Open Access   (Followers: 1)
Archive of Community Health     Open Access  
Archives of Biomedical Sciences     Open Access   (Followers: 7)
Archives of Medical and Biomedical Research     Open Access   (Followers: 3)
Archives of Medical Laboratory Sciences     Open Access   (Followers: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Trauma Research     Open Access   (Followers: 2)
Archivos de Medicina (Manizales)     Open Access  
ArgoSpine News & Journal     Hybrid Journal  
Arquivos Brasileiros de Oftalmologia     Open Access  
Arquivos de Ciências da Saúde     Open Access  
Arquivos de Medicina     Open Access  
ARS Medica Tomitana     Open Access   (Followers: 1)
Art Therapy: Journal of the American Art Therapy Association     Full-text available via subscription   (Followers: 10)
Arterial Hypertension     Open Access  
Artificial Intelligence in Medicine     Hybrid Journal   (Followers: 12)
Artificial Organs     Hybrid Journal   (Followers: 1)
Asia Pacific Family Medicine     Open Access  
Asia Pacific Journal of Clinical Nutrition     Full-text available via subscription   (Followers: 10)
Asia Pacific Journal of Clinical Trials : Nervous System Diseases     Open Access  
Asian Bioethics Review     Full-text available via subscription   (Followers: 1)
Asian Journal of Cell Biology     Open Access   (Followers: 6)
Asian Journal of Health     Open Access   (Followers: 3)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 2)
Asian Journal of Medical and Pharmaceutical Researches     Open Access   (Followers: 1)
Asian Journal of Medical Sciences     Open Access   (Followers: 1)
Asian Journal of Scientific Research     Open Access   (Followers: 1)
Asian Journal of Transfusion Science     Open Access   (Followers: 2)
Asian Medicine     Hybrid Journal   (Followers: 4)
ASPIRATOR : Journal of Vector-borne Disease Studies     Open Access  
Astrocyte     Open Access  
Atención Familiar     Open Access  
Atención Primaria     Open Access   (Followers: 1)
Audiology - Communication Research     Open Access   (Followers: 8)
Auris Nasus Larynx     Full-text available via subscription  
Australasian Medical Journal     Open Access   (Followers: 3)
Australian Coeliac     Full-text available via subscription   (Followers: 2)
Australian Family Physician     Full-text available via subscription   (Followers: 3)
Australian Journal of Medical Science     Full-text available via subscription   (Followers: 1)
Autopsy and Case Reports     Open Access  
Aviation, Space, and Environmental Medicine     Full-text available via subscription   (Followers: 9)
Avicenna     Open Access   (Followers: 2)
Avicenna Journal of Medicine     Open Access   (Followers: 1)
Bangabandhu Sheikh Mujib Medical University Journal     Open Access   (Followers: 1)
Bangladesh Journal of Anatomy     Open Access   (Followers: 1)
Bangladesh Journal of Bioethics     Open Access  
Bangladesh Journal of Medical Biochemistry     Open Access   (Followers: 3)
Bangladesh Journal of Medical Education     Open Access   (Followers: 2)
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Bangladesh Journal of Medical Physics     Open Access  
Bangladesh Journal of Medical Science     Open Access  
Bangladesh Journal of Medicine     Open Access   (Followers: 1)
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Bangladesh Medical Journal     Open Access  
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Bangladesh Medical Research Council Bulletin     Open Access  
Basal Ganglia     Hybrid Journal  
Basic Sciences of Medicine     Open Access   (Followers: 2)
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BC Medical Journal     Free  
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Bijblijven     Hybrid Journal  
Bijzijn     Hybrid Journal   (Followers: 2)
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Bioengineering & Translational Medicine     Open Access  
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Biologics in Therapy     Open Access  
Biology of Sex Differences     Open Access   (Followers: 4)
Biomarker Research     Open Access   (Followers: 2)

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Journal Cover Acta Medica Colombiana
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  This is an Open Access Journal Open Access journal
   ISSN (Print) 0120-2448
   Published by SciELO Homepage  [717 journals]
  • The application of knowledge

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  • Interventional treatment of mitral stenosis

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  • Myeloproliferative neoplasms. From clinic to molecular biology

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  • Long-term clinical and echocardiographic results of patients undergoing
           percutaneous mitral valvuloplasty

    • Abstract: Resumen Antecedentes: la valvuloplastia mitral percutánea con balón (VMPB) es un tratamiento efectivo y recomendado para pacientes con estenosis mitral (EM) moderada o severa. Objetivos: describir las características epidemiológicas, clínicas y ecocardiográficas de pacientes con estenosis mitral sometidos a VMPB en el momento del procedimiento y hacerles seguimiento a 5, 10 y 15 años. Diseño: retrospectiva de una cohorte de pacientes con EM intervenidos con VMPB en la Clínica CardioVID; se analizan las características epidemiológicas, clínicas y ecocardiográficas antes, después del procedimiento y a largo plazo. Se define supervivencia libre de reintervención si durante el tiempo de seguimiento los pacientes no presentan nueva VMPB o cirugía de reemplazo valvular. Los procedimientos fallidos se definen como un área valvular mitral (AVM) pos VMPB<1.5cm2 o insuficiencia mitral>2+. Se define restenosis al tener AVM <1.5 cm2 con pérdida de 50% o más del área ganada con la VMPB. Resultados: se analizaron 162 VMPB realizadas desde enero de 1993 hasta diciembre de 2011. La ecocardiografía pos VMPB mostró que el AVM aumentó de 0.95±0.24cm2 a 1.56±0.33cm2 (p<0.001) medida por planimetría y 0.96±0.24 cm2 a 1.69±0.41 cm2 (p <0.0001) calculada por tiempo de hemipresión. El gradiente medio transvalvular disminuyó desde 14.1±5.7 mmHg a 6.9±3.4 mmHg (p <0.001). La supervivencia libre de reintervención fue 74% a cinco años, 53% a 10 años y 42% a 15 años. El tiempo mediano de supervivencia fue 128.8±26.4 meses (IC 95% 76.8-180.7); en pacientes con procedimiento fallido fue 57.2±6.1 meses y en el grupo de procedimiento exitoso fue 185.4±25.9 meses (p<0.001). Conclusiones: la VMPB es un procedimiento efectivo que produce un aumento significativo del área valvular mitral y retrasa de forma significativa la necesidad de cirugía de reemplazo valvular. EL AVM pos VMPB<1.5 cm2 fue el principal determinante negativo en el pronóstico a largo plazo.Abstract Background: percutaneous mitral balloon valvuloplasty (PMBV) is an effective and recommended treatment for patients with moderate or severe mitral stenosis (MS). Objectives: to describe the epidemiological, clinical and echocardiographic characteristics of patients with mitral stenosis undergoing PMBV at the time of the procedure and to follow up at 5, 10 and 15 years. Design: retrospective review of a cohort of MS patients treated with PMBV at the CardioVID Clinic. The epidemiological, clinical and echocardiographic characteristics are analyzed before, after the procedure and in the long term. Reintervention-free survival is defined if during the follow-up period the patients do not undergo new PMBV or valve replacement surgery. Failed procedures are defined as a mitral valve area (MVA) pos PMBV <1.5cm2 or mitral insufficiency> 2+. Restenosis is defined as having MVA <1.5 cm2 with loss of 50% or more of the area gained with PMBV. Results: 162 PMBV realized from January 1993 to December 2011 were analized. Pos-PMBV echocardiography showed that MVA increased from 0.95 ± 0.24cm2 to 1.56 ± 0.33cm2 (p <0.001) as measured by planimetry and 0.96 ± 0.24 cm2 at 1.69 ± 0.41 cm 2 (p <0.0001) calculated by time of hemi pressure. The mean transvalvular gradient decreased from 14.1 ± 5.7 mmHg to 6.9 ± 3.4 mmHg (p <0.001). Survival free of reintervention was 74% at 5 years, 53% at 10 years and 42% at 15 years. Median survival time was 128.8 ± 26.4 months (95% CI 76.8-180.7); in patients with failed procedure was 57.2 ± 6.1 months and in the successful procedure group it was 185.4 ± 25.9 months (p <0.001). Conclusions: PMBV is an effective procedure that produces a significant increase in the mitral valve area and significantly delays the need for valve replacement surgery. The MVA pos PMBV <1.5 cm2 was the main negative determinant in the long-term prognosis.
       
  • Pulmonary disease caused by Mycobacterium avium complex and
           M. abscessus

    • Abstract: Resumen Introducción: después del complejo Mycobacterium tuberculosis, las principales especies de micobacterias causando enfermedad pulmonar son el complejo Mycobacterium avium (MAC) y Mycobacterium abscessus, el tratamiento es prolongado, presentan un amplio perfil de resistencia y algunas veces es necesaria la resección quirúrgica del tejido, dificultando la curación de algunos casos. Objetivo: realizar un análisis de los casos a los que se les aisló de muestras pulmonares MAC y M. abscessus en el periodo de 2012-2014 en el Laboratorio Nacional de Referencia de Colombia. Material y métodos: se realizó un estudio de serie de casos de 42 personas a las que se les aisló de muestras pulmonares MAC y M. abscessus, los cuales fueron identificados mediante pruebas fenotípicas y genotípicas. La fuente de información fue el Formato Único de Vigilancia de las Micobacterias que se recibe con cada uno de los aislados que llegan al INS. Se analizaron las variables edad, sexo, tipo de muestra y presencia de factores de riesgo. Resultados: en 32 de los casos se identificó MAC y en 10 M. abscessus como agente etiológico causante de enfermedad pulmonar, 26 (61.9%) de los casos tenían entre 51 y 86 años. Los principales factores de riesgo fueron: antecedente de tratamiento antituberculosis 16 (38.1%) y persona con VIH 7 (16.7%) y sin factor de riesgo 9 (21.2%) casos. Discusión: este trabajo reporta como agente etiológico MAC y M. abscessus en personas mayores de 50 años sin factores de riesgo, con antecedentes de tuberculosis, indicando que se debe fortalecer la realización de cultivo e identificación de especie en éstas para que tengan un adecuado diagnóstico y tratamiento.Abstract Introduction: after the Mycobacterium tuberculosis complex, the main species of mycobacteria causing lung disease are Mycobacterium avium complex and Mycobacterium abscessus. The treatment is prolonged; they present a broad resistance profile and sometimes the surgical resection of the tissue is necessary, making healing difficult in some cases. Objective: to perform an analysis of the cases to which MAC and M. abscessus were isolated from pulmonary samples in the period from 2012 to 2014 in the National Reference Laboratory of Colombia. Materials and Methods: a case series study of 42 individuals to whom Mac and M. abcessus were isolated from pulmonary samples that were identified by phenotypic and genotypic tests, was carried out. The source of information was the unique format of surveillance of mycobacteria that is received with each of the isolates that come to the National Health Institute. The variables age, sex, type of sample and presence of risk factors were analyzed. Results: in 32 patients MAC was identified as etiological agent causing pulmonary disease and in 10 cases, M. abscessus was the agent. 26 (61.9%) of the patients were between 51 and 86 years of age. The main risk factors were: antecedent of anti-tuberculosis treatment in16 (38.1%),7 with HIV (16.7%) and without risk factor 9 cases (21.2%).
       
  • Cardiovascular risk factors in adolescents in a city of Paraguay

    • Abstract: Resumen Introducción: los factores de riesgo cardiovascular aparecen tempranamente en la niñez y adolescencia. Los principales son: hipertensión arterial, obesidad, la dieta inadecuada, el sedentarismo, el alcoholismo y el tabaquismo. Objetivo: determinar la prevalencia de factores de riesgo cardiovascular en adolescentes del Colegio Nacional de Enseñanza Media Diversificada de Itá (Paraguay) que asistieron al control clínico en meses de marzo y abril del 2015. Metodología: estudio observacional, descriptivo, prospectivo, de corte transversal que incluyó a 132 adolescentes de ambos sexos. Resultados: las prevalencias fueron: hipertensión arterial sistólica 1.5%, sobrepeso 8.3%, obesidad 2.7%, sedentarismo 58.3%, tabaquismo 6.8% y han tomado alcohol ocasionalmente 47.7%. El sobrepeso y la obesidad no mostraron relación estadísticamente significativa con las cifras elevadas de presión arterial. Conclusiones: la prevalencia de hipertensión arterial y exceso de peso encontradas fueron bajas. Llama la atención la alta frecuencia de bajo peso y la tendencia al sedentarismo. Entre los tabaquistas, dos tercios corresponden al sexo femenino.Abstract Introduction: cardiovascular risk factors appear early in childhood and adolescence. The main ones are: arterial hypertension, obesity, inadequate diet, sedentary lifestyle, alcoholism and smoking. Objective: to determine the prevalence of cardiovascular risk factors in adolescents of the National School of Diversified Middle Education of Itá (Paraguay) who attended clinical control in March and April 2.015. Methodology: observational, descriptive, prospective, cross-sectional study that included 132 adolescents of both sexes. Results: prevalences were: systolic arterial hypertension 1.5%, overweight 8.3%, obesity 2.7%, sedentary lifestyle 58.3%, smoking 6.8% and occasional alcohol consumption 47.7%. Overweight and obesity did not show a statistically significant relationship with high blood pressure. Conclusions: the prevalence of arterial hypertension and excess weight found were low. Draws attention the high frequency of low weight and the tendency to sedentarism. Among smokers, twothirds correspond to women.
       
  • Description of the clinical characteristics of chronic myeloproliferative
           neoplasms (MPNs). First report of the colombian registry of MPNs

    • Abstract: Resumen Introducción y objetivos: las neoplasias mieloproliferativas crónicas (NMPC) son relativamente raras, con incidencias que varían entre 0.47-1.03/100 000 habitantes. Se presenta el primer informe del trabajo del registro colombiano de NMPC, cuyo objetivo es describir las características clínicas de estos pacientes en nuestro país. Material y métodos: estudio descriptivo observacional, multicéntrico, retrospectivo y prospectivo en ocho centros del país, de abril de 2013 a diciembre de 2014. Las variables cualitativas se presentan con frecuencias absolutas y relativas; y las cuantitativas se resumen en medidas de tendencia central y dispersión. Resultados: once centros fueron aprobados, ocho ingresaron pacientes. En los primeros 179 casos reportados, 50% eran hombres, la edad promedio al diagnóstico 58.7 años (rango 19-92). Noventa y tres muestran trombocitemia esencial (TE); 55, policitemia vera (PV); y 31, mielofibrosis (MF). El 41% tenía esplenomegalia al diagnóstico; el 20% tuvo complicaciones trombóticas; y 12.85%, sangrado. Sólo en 57.5% se realizó JAK; de ellos, en 53.5% fue positivo, en especial sólo 60% de las PV. El 8% de los casos no tenía estudio de médula ósea, el 29.3% tiene algún grado de fibrosis. El hallazgo más frecuente fue hiperplasia megacariocítica en 59.78%. Más de 50% de pacientes estaban sintomáticos al diagnóstico. Sólo el 11% no recibió tratamiento farmacológico; los más frecuentes fueron hidroxiurea en 149 casos y ASA en 79. Con promedio de seguimiento de 52.6 meses; el 97.21% de los pacientes están vivos. Conclusiones: los hallazgos sugieren que algunas características de las NMPC podrían ser diferentes a lo reportado en otras series, lo que valida la importancia del esfuerzo de recoger información local.Abstract Introduction and objectives: chronic MPNs are relatively rare, with incidences varying between 0.47-1.03 / 100 000 inhabitants. The first report of the work of the Colombian registry of chronic MPNs, whose objective is to describe the clinical characteristics of these patients in our country, is presented. Materials and methods: descriptive observational, multicenter, retrospective and prospective study in eight centers of the country, from April 2013 to December 2014. Qualitative variables are presented with absolute and relative frequencies, and the quantitative ones are summarized in measures of central tendency and dispersion. Results: eleven centers were approved; 8 admitted patients. In the first 179 cases reported, 50% were men; the average age at diagnosis was 58.7 years (range 19-92). Ninety-three present essential thrombocythemia (ET); 55, polycythemia vera (PV); and 31, myelofibrosis (MF). 41% had splenomegaly at diagnosis; 20% had thrombotic complications, and 12.85%, bleeding. JAK was performed in only 57.5%. Of them, in 53.5% was positive, especially in only 60% of the PV. 8% of the cases had no bone marrow study; 29.3% had some degree of fibrosis. The most frequent finding was megakaryocytic hyperplasia in 59.78%. More than 50% of patients were symptomatic at diagnosis. Only 11% did not receive pharmacological treatment, being the most frequent hydroxyurea in 149 cases and ASA in 79, with an average follow-up of 52.6 months. 97.21% of patients are alive. Conclusions: the findings suggest that some characteristics of chronic MPNs could be different from those reported in other series, which validates the importance of the effort to collect local information.
       
  • List of drug tracers/ markers as a tool in pharmacotherapeutic follow-up
           or drug-safety programs

    • Abstract: Resumen Introducción: los resultados negativos asociados a la medicación (RNM), incluyendo las reacciones adversas a medicamentos (RAM) o problemas de seguridad, son un problema clínico relevante, debido a su alta incidencia y a efectos nocivos en la salud. Un medicamento podría ser considerado como trazador/señalador, debido a: 1) una mayor probabilidad de causar RAM o problemas de seguridad; o 2) su utilización para tratar y por tanto identificar pacientes con RAM. Los listados de medicamentos trazadores podrían ser útiles en los programas de farmacoseguridad o seguimiento farmacoterapéutico (SFT). Objetivo: el objetivo de este trabajo fue estructurar un listado de medicamentos trazadores/ señaladores de los pacientes con mayor riesgo de presentar RNM, el cual podría ser útil para seleccionar pacientes para programas de SFT o farmacoseguridad. Obtención de datos: inicialmente, se realizó una revisión estructurada en PubMed/Medline para identificar medicamentos asociados a la presentación de RAM clasificadas como graves o moderadas y con una prevalencia igual o superior a 10%. Posteriormente, el listado de medicamentos identificados, fue comparado y complementado con medicamentos de alta alerta del Institute for Safe Medication Practices (ISMP) y con medicamentos utilizados para el tratamiento de RAM o antídotos. Resultados: se generó un listado general de 139 medicamentos trazadores/señaladores. Conclusiones: este listado podría ser una herramienta para detectar y seleccionar los pacientes que más se podrían beneficiar de los programas de SFT o farmacoseguridad. Se requiere de la realización de estudios diseñados para evaluar la utilidad práctica de dicho listado.Abstract Introduction: negative outcomes associated with medication (NOM), including adverse drug reactions (ADRs) or safety problems, are a relevant clinical problem due to their high incidence and harmful effects on health. A drug could be considered a tracer / marker because of: 1) an increased likelihood of causing ADR or safety problems; or 2) its use to treat and therefore identify patients with ADR. Tracer drug listings could be useful in pharmacological safety or pharmacotherapeutic monitoring programs. Objective: the objective of this study was to structure a list of drug tracer / markers of the patients with the highest risk of presenting NOM, which could be useful to select patients for FFT or pharmacological safety programs. Data collection: initially, a structured review was performed in PubMed / Medline to identify drugs associated with the presentation of ADRs classified as severe or moderate and with a prevalence of 10% or greater. Subsequently, the list of identified medications was compared and complemented with high alert medications of the Institute for Safe Medication Practices (ISMP) and medications used to treat ADRs or antidotes. Results: a general listing of 139 drug tracers / markers was generated. Conclusions: this listing could be a tool to detect and select the patients who could most benefit from the FTS or pharmacological safety programs. Studies designed to evaluate the practical usefulness of this listing are required.
       
  • On the deepest issues of the medical profession

    • Abstract: Resumen Introducción: los resultados negativos asociados a la medicación (RNM), incluyendo las reacciones adversas a medicamentos (RAM) o problemas de seguridad, son un problema clínico relevante, debido a su alta incidencia y a efectos nocivos en la salud. Un medicamento podría ser considerado como trazador/señalador, debido a: 1) una mayor probabilidad de causar RAM o problemas de seguridad; o 2) su utilización para tratar y por tanto identificar pacientes con RAM. Los listados de medicamentos trazadores podrían ser útiles en los programas de farmacoseguridad o seguimiento farmacoterapéutico (SFT). Objetivo: el objetivo de este trabajo fue estructurar un listado de medicamentos trazadores/ señaladores de los pacientes con mayor riesgo de presentar RNM, el cual podría ser útil para seleccionar pacientes para programas de SFT o farmacoseguridad. Obtención de datos: inicialmente, se realizó una revisión estructurada en PubMed/Medline para identificar medicamentos asociados a la presentación de RAM clasificadas como graves o moderadas y con una prevalencia igual o superior a 10%. Posteriormente, el listado de medicamentos identificados, fue comparado y complementado con medicamentos de alta alerta del Institute for Safe Medication Practices (ISMP) y con medicamentos utilizados para el tratamiento de RAM o antídotos. Resultados: se generó un listado general de 139 medicamentos trazadores/señaladores. Conclusiones: este listado podría ser una herramienta para detectar y seleccionar los pacientes que más se podrían beneficiar de los programas de SFT o farmacoseguridad. Se requiere de la realización de estudios diseñados para evaluar la utilidad práctica de dicho listado.Abstract Introduction: negative outcomes associated with medication (NOM), including adverse drug reactions (ADRs) or safety problems, are a relevant clinical problem due to their high incidence and harmful effects on health. A drug could be considered a tracer / marker because of: 1) an increased likelihood of causing ADR or safety problems; or 2) its use to treat and therefore identify patients with ADR. Tracer drug listings could be useful in pharmacological safety or pharmacotherapeutic monitoring programs. Objective: the objective of this study was to structure a list of drug tracer / markers of the patients with the highest risk of presenting NOM, which could be useful to select patients for FFT or pharmacological safety programs. Data collection: initially, a structured review was performed in PubMed / Medline to identify drugs associated with the presentation of ADRs classified as severe or moderate and with a prevalence of 10% or greater. Subsequently, the list of identified medications was compared and complemented with high alert medications of the Institute for Safe Medication Practices (ISMP) and medications used to treat ADRs or antidotes. Results: a general listing of 139 drug tracers / markers was generated. Conclusions: this listing could be a tool to detect and select the patients who could most benefit from the FTS or pharmacological safety programs. Studies designed to evaluate the practical usefulness of this listing are required.
       
  • Severe functional mitral regurgitation, Percutaneous mitral valve repair
           with the mitraclip system, a safe option for patients who can not be taken
           to surgery

    • Abstract: Resumen La regurgitación mitral funcional (RMF) es una complicación frecuente en pacientes que cursan con una falla cardiaca dilatada, se desarrolla como consecuencia de la remodelación y crecimiento de cavidades que lleva a un incremento de las fuerzas que traicionan el aparato valvular mitral causando su mal funcionamiento. La RMF es una causa conocida de disnea, deterioro funcional, isquemia miocárdica y de disfunción ventricular, a pesar de la terapia medica disponible, causa deterioro de la calidad de vida de los pacientes y de ingresos frecuentes a los servicios de urgencias por descompensaciones. Reportamos un caso de RMF con riesgo alto para cirugía correctiva, con deterioro de su calidad de vida, llevada a implante de clip mitral de forma exitosa y sin complicaciones.Abstract Functional mitral regurgitation (MR) is a common complication in patients with dilated cardiac failure. It develops as a consequence of the remodeling and growth of cavities leading to an increase in the forces that pull the mitral valve apparatus causing its malfunction. Functional MR is a known cause of dyspnea, functional deterioration, myocardial ischemia and ventricular dysfunction. Despite the available medical therapy it causes deterioration of the quality of life of the patients and frequent admissions to the emergency services due to decompensation. A case of functional MR with high risk for corrective surgery with deterioration of the quality of life that led to a successful mitral valve implant without complications, is presented.
       
  • Idiopathic pulmonary hemosiderosis in an adult patient

    • Abstract: Resumen Se presenta el caso de una paciente de 46 años de edad con cinco años de evolución de episodios intermitentes de hemoptisis cuyo diagnóstico final fue hemosiderosis pulmonar idiopática. Su presentación y características clínicas son comparadas con los otros casos reportados en la literatura.Abstract The case of a 46-year-old patient with five years of evolution of intermittent episodes of hemoptysis whose final diagnosis was idiopathic pulmonary hemosiderosis is reported. Its presentation and clinical characteristics are compared with the other cases reported in the literature.
       
  • Pleural effusion associated with valproic acid use

    • Abstract: Resumen Las reacciones adversas medicamentosas son ampliamente conocidas, sin embargo, existen algunas reacciones menos frecuentes que otras. El derrame pleural secundario al uso de ácido valproico, es una entidad clínica excepcional y por lo tanto difícilmente diagnosticada. Se presenta el caso de una mujer de 59 años de edad quien padece de parálisis cerebral y epilepsia; recibió manejo con ácido valproico y presento múltiples hospitalizaciones en contexto de neumonía y derrame pleural de difícil manejo, del cual no se encontró etiología infecciosa, oncológica o autoinmune. Después de observar eosinofilia en líquido pleural y en sangre, se sospechó asociación a uso de ácido valproico. Se suspendió el medicamento obteniendo resolución del derrame pleural, confirmando así esta asociación. En la literatura se han reportado muy pocos casos y hacen referencia a aquel derrame pleural de etiología no filiada que puede asociarse con eosinofilia o infiltrado linfocítico (menos frecuente) en el líquido pleural y acompañarse o no de eosinofilia sérica. En todos los reportes se ha encontrado un factor común clínicamente relevante. La resolución completa del derrame pleural al suspender la medicación.Abstract Adverse drug reactions are widely known; however, there are some reactions less frequent than others. The pleural effusion secondary to the use of Valproic acid is an exceptional clinical entity and therefore difficult to diagnose. The case of a 59-year-old woman who suffers from cerebral palsy and epilepsy is presented. She received management with Valproic acid and presented multiple hospitalizations in the context of pneumonia and pleural effusion of difficult management. Infectious, oncological or autoimmune etiology was not found. After observing eosinophilia in pleural fluid and in blood, association with Valproic acid was suspected. The drug was discontinued obtaining resolution of the pleural effusion, thus confirming this association. In the literature, very few cases have been reported and refer to pleural effusion of non-affiliated etiology that may be associated with eosinophilia or lymphocytic infiltrate (less frequent) in the pleural fluid and with or without serum eosinophilia. A clinically relevant common factor has been found in all reports, which is the complete resolution of pleural effusion upon discontinuation of the medication.
       
  • Arthritis mutilans. Catastrophic outcome potentially preventable

    • Abstract: Resumen Las reacciones adversas medicamentosas son ampliamente conocidas, sin embargo, existen algunas reacciones menos frecuentes que otras. El derrame pleural secundario al uso de ácido valproico, es una entidad clínica excepcional y por lo tanto difícilmente diagnosticada. Se presenta el caso de una mujer de 59 años de edad quien padece de parálisis cerebral y epilepsia; recibió manejo con ácido valproico y presento múltiples hospitalizaciones en contexto de neumonía y derrame pleural de difícil manejo, del cual no se encontró etiología infecciosa, oncológica o autoinmune. Después de observar eosinofilia en líquido pleural y en sangre, se sospechó asociación a uso de ácido valproico. Se suspendió el medicamento obteniendo resolución del derrame pleural, confirmando así esta asociación. En la literatura se han reportado muy pocos casos y hacen referencia a aquel derrame pleural de etiología no filiada que puede asociarse con eosinofilia o infiltrado linfocítico (menos frecuente) en el líquido pleural y acompañarse o no de eosinofilia sérica. En todos los reportes se ha encontrado un factor común clínicamente relevante. La resolución completa del derrame pleural al suspender la medicación.Abstract Adverse drug reactions are widely known; however, there are some reactions less frequent than others. The pleural effusion secondary to the use of Valproic acid is an exceptional clinical entity and therefore difficult to diagnose. The case of a 59-year-old woman who suffers from cerebral palsy and epilepsy is presented. She received management with Valproic acid and presented multiple hospitalizations in the context of pneumonia and pleural effusion of difficult management. Infectious, oncological or autoimmune etiology was not found. After observing eosinophilia in pleural fluid and in blood, association with Valproic acid was suspected. The drug was discontinued obtaining resolution of the pleural effusion, thus confirming this association. In the literature, very few cases have been reported and refer to pleural effusion of non-affiliated etiology that may be associated with eosinophilia or lymphocytic infiltrate (less frequent) in the pleural fluid and with or without serum eosinophilia. A clinically relevant common factor has been found in all reports, which is the complete resolution of pleural effusion upon discontinuation of the medication.
       
  • Severe or grave'

    • Abstract: Resumen Las reacciones adversas medicamentosas son ampliamente conocidas, sin embargo, existen algunas reacciones menos frecuentes que otras. El derrame pleural secundario al uso de ácido valproico, es una entidad clínica excepcional y por lo tanto difícilmente diagnosticada. Se presenta el caso de una mujer de 59 años de edad quien padece de parálisis cerebral y epilepsia; recibió manejo con ácido valproico y presento múltiples hospitalizaciones en contexto de neumonía y derrame pleural de difícil manejo, del cual no se encontró etiología infecciosa, oncológica o autoinmune. Después de observar eosinofilia en líquido pleural y en sangre, se sospechó asociación a uso de ácido valproico. Se suspendió el medicamento obteniendo resolución del derrame pleural, confirmando así esta asociación. En la literatura se han reportado muy pocos casos y hacen referencia a aquel derrame pleural de etiología no filiada que puede asociarse con eosinofilia o infiltrado linfocítico (menos frecuente) en el líquido pleural y acompañarse o no de eosinofilia sérica. En todos los reportes se ha encontrado un factor común clínicamente relevante. La resolución completa del derrame pleural al suspender la medicación.Abstract Adverse drug reactions are widely known; however, there are some reactions less frequent than others. The pleural effusion secondary to the use of Valproic acid is an exceptional clinical entity and therefore difficult to diagnose. The case of a 59-year-old woman who suffers from cerebral palsy and epilepsy is presented. She received management with Valproic acid and presented multiple hospitalizations in the context of pneumonia and pleural effusion of difficult management. Infectious, oncological or autoimmune etiology was not found. After observing eosinophilia in pleural fluid and in blood, association with Valproic acid was suspected. The drug was discontinued obtaining resolution of the pleural effusion, thus confirming this association. In the literature, very few cases have been reported and refer to pleural effusion of non-affiliated etiology that may be associated with eosinophilia or lymphocytic infiltrate (less frequent) in the pleural fluid and with or without serum eosinophilia. A clinically relevant common factor has been found in all reports, which is the complete resolution of pleural effusion upon discontinuation of the medication.
       
  • Embolism or embolia, Paradox embolism or paradogic embolia

    • Abstract: Resumen Las reacciones adversas medicamentosas son ampliamente conocidas, sin embargo, existen algunas reacciones menos frecuentes que otras. El derrame pleural secundario al uso de ácido valproico, es una entidad clínica excepcional y por lo tanto difícilmente diagnosticada. Se presenta el caso de una mujer de 59 años de edad quien padece de parálisis cerebral y epilepsia; recibió manejo con ácido valproico y presento múltiples hospitalizaciones en contexto de neumonía y derrame pleural de difícil manejo, del cual no se encontró etiología infecciosa, oncológica o autoinmune. Después de observar eosinofilia en líquido pleural y en sangre, se sospechó asociación a uso de ácido valproico. Se suspendió el medicamento obteniendo resolución del derrame pleural, confirmando así esta asociación. En la literatura se han reportado muy pocos casos y hacen referencia a aquel derrame pleural de etiología no filiada que puede asociarse con eosinofilia o infiltrado linfocítico (menos frecuente) en el líquido pleural y acompañarse o no de eosinofilia sérica. En todos los reportes se ha encontrado un factor común clínicamente relevante. La resolución completa del derrame pleural al suspender la medicación.Abstract Adverse drug reactions are widely known; however, there are some reactions less frequent than others. The pleural effusion secondary to the use of Valproic acid is an exceptional clinical entity and therefore difficult to diagnose. The case of a 59-year-old woman who suffers from cerebral palsy and epilepsy is presented. She received management with Valproic acid and presented multiple hospitalizations in the context of pneumonia and pleural effusion of difficult management. Infectious, oncological or autoimmune etiology was not found. After observing eosinophilia in pleural fluid and in blood, association with Valproic acid was suspected. The drug was discontinued obtaining resolution of the pleural effusion, thus confirming this association. In the literature, very few cases have been reported and refer to pleural effusion of non-affiliated etiology that may be associated with eosinophilia or lymphocytic infiltrate (less frequent) in the pleural fluid and with or without serum eosinophilia. A clinically relevant common factor has been found in all reports, which is the complete resolution of pleural effusion upon discontinuation of the medication.
       
  • Hypoventilation

    • Abstract: Resumen Las reacciones adversas medicamentosas son ampliamente conocidas, sin embargo, existen algunas reacciones menos frecuentes que otras. El derrame pleural secundario al uso de ácido valproico, es una entidad clínica excepcional y por lo tanto difícilmente diagnosticada. Se presenta el caso de una mujer de 59 años de edad quien padece de parálisis cerebral y epilepsia; recibió manejo con ácido valproico y presento múltiples hospitalizaciones en contexto de neumonía y derrame pleural de difícil manejo, del cual no se encontró etiología infecciosa, oncológica o autoinmune. Después de observar eosinofilia en líquido pleural y en sangre, se sospechó asociación a uso de ácido valproico. Se suspendió el medicamento obteniendo resolución del derrame pleural, confirmando así esta asociación. En la literatura se han reportado muy pocos casos y hacen referencia a aquel derrame pleural de etiología no filiada que puede asociarse con eosinofilia o infiltrado linfocítico (menos frecuente) en el líquido pleural y acompañarse o no de eosinofilia sérica. En todos los reportes se ha encontrado un factor común clínicamente relevante. La resolución completa del derrame pleural al suspender la medicación.Abstract Adverse drug reactions are widely known; however, there are some reactions less frequent than others. The pleural effusion secondary to the use of Valproic acid is an exceptional clinical entity and therefore difficult to diagnose. The case of a 59-year-old woman who suffers from cerebral palsy and epilepsy is presented. She received management with Valproic acid and presented multiple hospitalizations in the context of pneumonia and pleural effusion of difficult management. Infectious, oncological or autoimmune etiology was not found. After observing eosinophilia in pleural fluid and in blood, association with Valproic acid was suspected. The drug was discontinued obtaining resolution of the pleural effusion, thus confirming this association. In the literature, very few cases have been reported and refer to pleural effusion of non-affiliated etiology that may be associated with eosinophilia or lymphocytic infiltrate (less frequent) in the pleural fluid and with or without serum eosinophilia. A clinically relevant common factor has been found in all reports, which is the complete resolution of pleural effusion upon discontinuation of the medication.
       
 
 
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