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MEDICAL SCIENCES (2235 journals)                  1 2 3 4 5 6 7 8 | Last

Showing 1 - 200 of 3562 Journals sorted alphabetically
16 de Abril     Open Access   (Followers: 1)
3D Printing in Medicine     Open Access   (Followers: 4)
4 open     Open Access  
AADE in Practice     Hybrid Journal   (Followers: 6)
ABCS Health Sciences     Open Access   (Followers: 7)
Abia State University Medical Students' Association Journal     Full-text available via subscription   (Followers: 2)
AboutOpen     Open Access  
ACIMED     Open Access   (Followers: 1)
ACS Medicinal Chemistry Letters     Hybrid Journal   (Followers: 46)
Acta Bio Medica     Full-text available via subscription   (Followers: 2)
Acta Bioethica     Open Access  
Acta Bioquimica Clinica Latinoamericana     Open Access   (Followers: 1)
Acta Científica Estudiantil     Open Access  
Acta Facultatis Medicae Naissensis     Open Access  
Acta Herediana     Open Access  
Acta Informatica Medica     Open Access  
Acta Medica (Hradec Králové)     Open Access  
Acta Medica Bulgarica     Open Access  
Acta Medica Colombiana     Open Access   (Followers: 1)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Medica Indonesiana     Open Access  
Acta Medica International     Open Access  
Acta medica Lituanica     Open Access  
Acta Medica Marisiensis     Open Access  
Acta Medica Martiniana     Open Access  
Acta Medica Nagasakiensia     Open Access   (Followers: 1)
Acta Medica Peruana     Open Access   (Followers: 2)
Acta Médica Portuguesa     Open Access  
Acta Medica Saliniana     Open Access  
Acta Scientiarum. Health Sciences     Open Access   (Followers: 2)
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 6)
Acupuncture and Natural Medicine     Open Access  
Addiction Science & Clinical Practice     Open Access   (Followers: 8)
Addictive Behaviors Reports     Open Access   (Followers: 9)
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / Health Sciences Journal of Adıyaman University     Open Access   (Followers: 1)
Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi     Open Access  
Advanced Biomedical Research     Open Access  
Advanced Health Care Technologies     Open Access   (Followers: 8)
Advanced Science, Engineering and Medicine     Partially Free   (Followers: 8)
Advanced Therapeutics     Hybrid Journal  
Advances in Bioscience and Clinical Medicine     Open Access   (Followers: 7)
Advances in Cell and Gene Therapy     Hybrid Journal  
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 26)
Advances in Life Course Research     Hybrid Journal   (Followers: 9)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Medical Education and Practice     Open Access   (Followers: 32)
Advances in Medical Ethics     Open Access   (Followers: 1)
Advances in Medical Research     Open Access   (Followers: 1)
Advances in Medical Sciences     Hybrid Journal   (Followers: 9)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Medicine     Open Access   (Followers: 3)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 5)
Advances in Molecular Oncology     Open Access   (Followers: 2)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7)
Advances in Parkinson's Disease     Open Access  
Advances in Phytomedicine     Full-text available via subscription  
Advances in Preventive Medicine     Open Access   (Followers: 6)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20)
Advances in Regenerative Medicine     Open Access   (Followers: 3)
Advances in Skeletal Muscle Function Assessment     Open Access  
Advances in Therapy     Hybrid Journal   (Followers: 5)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 15)
Advances in Virus Research     Full-text available via subscription   (Followers: 6)
Advances in Wound Care     Hybrid Journal   (Followers: 12)
Aerospace Medicine and Human Performance     Full-text available via subscription   (Followers: 13)
African Health Sciences     Open Access   (Followers: 3)
African Journal of Biomedical Research     Open Access   (Followers: 1)
African Journal of Clinical and Experimental Microbiology     Open Access   (Followers: 4)
African Journal of Laboratory Medicine     Open Access   (Followers: 2)
African Journal of Medical and Health Sciences     Open Access   (Followers: 3)
African Journal of Thoracic and Critical Care Medicine     Open Access  
African Journal of Trauma     Open Access   (Followers: 1)
Afrimedic Journal     Open Access   (Followers: 2)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 9)
AJOB Empirical Bioethics     Hybrid Journal   (Followers: 3)
AJSP: Reviews & Reports     Hybrid Journal  
Aktuelle Ernährungsmedizin     Hybrid Journal   (Followers: 4)
Al-Azhar Assiut Medical Journal     Open Access   (Followers: 2)
ALERTA : Revista Científica del Instituto Nacional de Salud     Open Access  
Alexandria Journal of Medicine     Open Access   (Followers: 1)
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 3)
Alpha Omegan     Full-text available via subscription  
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 2)
Althea Medical Journal     Open Access   (Followers: 2)
American Journal of Biomedical Engineering     Open Access   (Followers: 15)
American Journal of Biomedical Research     Open Access   (Followers: 2)
American Journal of Biomedicine     Full-text available via subscription   (Followers: 7)
American Journal of Chinese Medicine, The     Hybrid Journal   (Followers: 4)
American Journal of Clinical Medicine Research     Open Access   (Followers: 8)
American Journal of Family Therapy     Hybrid Journal   (Followers: 10)
American Journal of Law & Medicine     Full-text available via subscription   (Followers: 11)
American Journal of Lifestyle Medicine     Hybrid Journal   (Followers: 5)
American Journal of Managed Care     Full-text available via subscription   (Followers: 12)
American Journal of Medical Case Reports     Open Access   (Followers: 1)
American Journal of Medical Sciences and Medicine     Open Access   (Followers: 4)
American Journal of Medicine     Hybrid Journal   (Followers: 50)
American Journal of Medicine and Medical Sciences     Open Access   (Followers: 1)
American Journal of Medicine Studies     Open Access   (Followers: 2)
American Journal of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American Journal of the Medical Sciences     Hybrid Journal   (Followers: 12)
American Journal on Addictions     Hybrid Journal   (Followers: 10)
American medical news     Free   (Followers: 3)
American Medical Writers Association Journal     Full-text available via subscription   (Followers: 5)
Amyloid: The Journal of Protein Folding Disorders     Hybrid Journal   (Followers: 5)
Anales de la Facultad de Medicina     Open Access  
Anales de la Facultad de Medicina, Universidad de la República, Uruguay     Open Access  
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1)
Analgesia & Resuscitation : Current Research     Hybrid Journal   (Followers: 6)
Anatolian Clinic the Journal of Medical Sciences     Open Access  
Anatomica Medical Journal     Open Access  
Anatomical Science International     Hybrid Journal   (Followers: 3)
Anatomical Sciences Education     Hybrid Journal   (Followers: 1)
Anatomy     Open Access   (Followers: 2)
Anatomy Research International     Open Access   (Followers: 3)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3)
Ankara Medical Journal     Open Access   (Followers: 2)
Ankara Üniversitesi Tıp Fakültesi Mecmuası     Open Access  
Annales de Pathologie     Full-text available via subscription  
Annales des Sciences de la Santé     Open Access  
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 3)
Annals of African Medicine     Open Access   (Followers: 2)
Annals of Anatomy - Anatomischer Anzeiger     Hybrid Journal   (Followers: 3)
Annals of Bioanthropology     Open Access   (Followers: 5)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 19)
Annals of Biomedical Sciences     Full-text available via subscription   (Followers: 4)
Annals of Clinical Hypertension     Open Access  
Annals of Clinical Microbiology and Antimicrobials     Open Access   (Followers: 14)
Annals of Family Medicine     Open Access   (Followers: 14)
Annals of Health Research     Open Access   (Followers: 1)
Annals of Ibadan Postgraduate Medicine     Open Access  
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Medicine     Hybrid Journal   (Followers: 12)
Annals of Medicine and Surgery     Open Access   (Followers: 7)
Annals of Microbiology     Hybrid Journal   (Followers: 13)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Rehabilitation Medicine     Open Access  
Annals of Saudi Medicine     Open Access  
Annals of the New York Academy of Sciences     Hybrid Journal   (Followers: 5)
Annals of The Royal College of Surgeons of England     Full-text available via subscription   (Followers: 3)
Annual Reports in Medicinal Chemistry     Full-text available via subscription   (Followers: 7)
Annual Reports on NMR Spectroscopy     Full-text available via subscription   (Followers: 5)
Annual Review of Medicine     Full-text available via subscription   (Followers: 17)
Anthropological Review     Open Access   (Followers: 24)
Anthropologie et santé     Open Access   (Followers: 5)
Antibiotics     Open Access   (Followers: 9)
Antibodies     Open Access   (Followers: 2)
Antibody Technology Journal     Open Access   (Followers: 1)
Antibody Therapeutics     Open Access  
Anuradhapura Medical Journal     Open Access  
Anwer Khan Modern Medical College Journal     Open Access   (Followers: 2)
Apmis     Hybrid Journal   (Followers: 1)
Apparence(s)     Open Access   (Followers: 1)
Applied Clinical Informatics     Hybrid Journal   (Followers: 4)
Applied Clinical Research, Clinical Trials and Regulatory Affairs     Hybrid Journal   (Followers: 2)
Applied Medical Informatics     Open Access   (Followers: 13)
Arab Journal of Nephrology and Transplantation     Open Access   (Followers: 1)
Archive of Clinical Medicine     Open Access   (Followers: 1)
Archive of Community Health     Open Access   (Followers: 1)
Archives Medical Review Journal / Arşiv Kaynak Tarama Dergisi     Open Access  
Archives of Asthma, Allergy and Immunology     Open Access  
Archives of Medical and Biomedical Research     Open Access   (Followers: 3)
Archives of Medical Laboratory Sciences     Open Access   (Followers: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 4)
Archives of Medicine and Surgery     Open Access  
Archives of Trauma Research     Open Access   (Followers: 3)
Archivos de Medicina (Manizales)     Open Access  
ArgoSpine News & Journal     Hybrid Journal  
Arquivos Brasileiros de Oftalmologia     Open Access   (Followers: 1)
Arquivos de Ciências da Saúde     Open Access  
Arquivos de Medicina     Open Access  
Ars Medica : Revista de Ciencias Médicas     Open Access  
ARS Medica Tomitana     Open Access   (Followers: 1)
Art Therapy: Journal of the American Art Therapy Association     Hybrid Journal   (Followers: 17)
Arterial Hypertension     Open Access   (Followers: 1)
Artificial Intelligence in Medicine     Hybrid Journal   (Followers: 18)
Artificial Organs     Hybrid Journal   (Followers: 1)
ASHA Leader     Open Access  
Asia Pacific Family Medicine     Open Access   (Followers: 1)
Asia Pacific Journal of Clinical Nutrition     Full-text available via subscription   (Followers: 12)
Asia Pacific Journal of Clinical Trials : Nervous System Diseases     Open Access  
Asian Bioethics Review     Full-text available via subscription   (Followers: 3)
Asian Biomedicine     Open Access   (Followers: 2)
Asian Journal of Cell Biology     Open Access   (Followers: 5)
Asian Journal of Health     Open Access   (Followers: 3)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 4)
Asian Journal of Medical and Pharmaceutical Researches     Open Access   (Followers: 2)
Asian Journal of Medical Sciences     Open Access   (Followers: 2)
Asian Journal of Scientific Research     Open Access   (Followers: 3)
Asian Journal of Transfusion Science     Open Access   (Followers: 1)
Asian Medicine     Hybrid Journal   (Followers: 5)
Asian Pacific Journal of Cancer Prevention     Open Access  
ASPIRATOR : Journal of Vector-borne Disease Studies     Open Access  
Astrocyte     Open Access  
Atención Familiar     Open Access  
Atención Primaria     Open Access   (Followers: 1)
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche     Open Access  
Audiology - Communication Research     Open Access   (Followers: 10)
Auris Nasus Larynx     Full-text available via subscription  

        1 2 3 4 5 6 7 8 | Last

Similar Journals
Journal Cover
Annual Reports in Medicinal Chemistry
Journal Prestige (SJR): 0.33
Citation Impact (citeScore): 1
Number of Followers: 7  
  Full-text available via subscription Subscription journal
ISSN (Print) 0065-7743
Published by Elsevier Homepage  [3177 journals]
  • Shortcuts to schistosomiasis drug discovery: The state-of-the-art
    • Abstract: Publication date: Available online 18 October 2019Source: Annual Reports in Medicinal ChemistryAuthor(s): José T. Moreira-Filho, Rafael F. Dantas, Mário R. Senger, Arthur C. Silva, Dulcinea M.B. Campos, Eugene Muratov, Floriano P. Silva-Junior, Carolina H. Andrade, Bruno J. NevesAbstractThe exclusive use of praziquantel for the treatment of schistosomiasis has raised concerns about the urgency of new antischistosomal therapies. Nonetheless, pharmaceutical industry still underinvests in new antischistosomal drugs and current drug discovery approaches present technical limitations. So, the demand for innovative antischistosomal drug discovery approaches gain significance in scientific community. In this scenario, the “automation of drug discovery” bears the promise of making better decisions faster and increasing hit rates in the process. Herein, we focus on the current development in antischistosomal lead discovery, specifically referring to the use of automated whole-organism and target-based screens, fragment-based drug design, and cheminformatics-based decision support. We highlight the strengths and pitfalls of each of the above-mentioned approaches and suggest possible roadmaps toward the integration of several strategies, which may contribute to optimizing research outputs and led to more successful and cost-effective drug discovery endeavors.
  • Recent advances in the design of inhibitors of mycobacterial
           transcriptional regulators to boost thioamides anti-tubercular activity
           and circumvent acquired-resistance
    • Abstract: Publication date: Available online 29 August 2019Source: Annual Reports in Medicinal ChemistryAuthor(s): Nicolas Willand, Marion Flipo, Baptiste Villemagne, Alain Baulard, Benoit DeprezAbstractSince few years, tuberculosis (TB) rivals AIDS as the leading cause of death worldwide. In addition, multidrug-resistant-TB (MDR-TB) has emerged as a major concern. Therapeutic solutions to stem this scourge are based on a 2–4 year treatment regimen of second-line drug cocktails, often associated with serious side effects, which does not facilitate patients compliance. In parallel to the search for new class of antibiotics, the development of alternative strategies to improve the efficacy of drugs already used in the clinic has been proposed. One of these strategies takes advantage of the fact that many anti-TB drugs are bioactivated by specific mycobacterial enzymes. Bioactivation of ethionamide or prothionamide, leading to inhibition of mycolic acids biosynthesis, involves a flavin-dependent Baeyer-Villiger monooxygenase called EthA, which expression is under the control of the transcriptional repressor EthR. A new therapeutic concept emerged from this observation and the development of EthR inhibitors was proposed as a solution to improve ethionamide efficacy. In this chapter, we outline the most recent efforts of different research groups, using modern drug discovery strategies that led to the design, discovery and optimization of the first inhibitors of EthR and boosters of ETH bioactivation in vitro and in vivo. We finally discuss the limitations of this approach and we highlight the breakthroughs in the identification of new chemical series and alternative bioactivation pathways. This discovery paves the way for the clinical development of a combination allowing thioamides to return fully active against all sensitive or resistant clinical isolates.
  • Dealing with schistosomiasis: Current drug discovery strategies
    • Abstract: Publication date: Available online 17 July 2019Source: Annual Reports in Medicinal ChemistryAuthor(s): Sandra Gemma, Stefano Federico, Simone Brogi, Margherita Brindisi, Stefania Butini, Giuseppe CampianiAbstractSchistosomiasis is one of the most prevalent parasitic diseases, accounting for heavy socioeconomical and health burden in endemic countries. The control of this neglected tropical disease mainly relies on mass drug administration of praziquantel, the only effective, safe and affordable drug currently available for both treatment and prevention. New drugs against schistosomiasis are urgently needed for both control and elimination of this pathogenic agent. The most recent hit and lead compounds as potential antischistosomal agents and the strategies used for their identification will be reviewed.
  • Antituberculosis agents: Beyond medicinal chemistry rules
    • Abstract: Publication date: Available online 2 July 2019Source: Annual Reports in Medicinal ChemistryAuthor(s): Marco PieroniAbstractMycobacterial infections are among the most widespread infectious diseases worldwide. For instance, tuberculosis (TB) is one of the top 10 causes of death worldwide and it is the leading cause from a single infectious agent. Of particular concern is the growing number of drug-resistant mycobacterial strains, that requires therapy prolongation and the use of less effective and more toxic drugs. One of the challenges in the treatment of TB is represented by the peculiar structure of the mycobacterial cell wall, which represents an effective defense against external insults, since its poor accessibility. For these reasons, the treatment is based on the administration of a cocktail of antimycobacterial drugs that must be prolonged (6-month standard) promoting, in turn, the occurrence of resistance. The search for novel effective therapeutic regimens has led to a nourished TB pipeline that mostly includes new chemical entities characterized by high killing potency and innovative mechanism of action. Alongside, “non-antimicrobial” host- and pathogen-directed therapies are emerging as effective strategies to support the standard treatment. Analysis of the molecules in the pipeline demonstrates that antituberculosis agents, either antimicrobial or adjuvant, are rarely compliant with the most common medicinal chemistry rules and largely evade the boundaries of drug-likeness, resulting in a “stand-alone” pharmaceutical class. In this chapter, the structural characteristics of several molecules in the TB pipeline are critically reviewed, and useful suggestions for the design of the next-generation antituberculosis drugs, both antimicrobial and adjuvant, are provided.
  • Sustainable anti-trypanosomatid drugs: An aspirational goal for medicinal
    • Abstract: Publication date: Available online 20 June 2019Source: Annual Reports in Medicinal ChemistryAuthor(s): Maria Laura BolognesiAbstractAlthough the progress made, poverty-related trypanosomatid diseases remain an area of concern for the drug discovery community. The inadequacy of available treatments, especially in terms of low access, high toxicity and complicated administration regimens, calls for endeavors focused on sustainable principles. These should guide all involved stakeholders, including medicinal chemists. Accordingly, a strategy exploiting privileged-structures-based phenotypic libraries might be useful to identify hits in a cost- and time-effective manner. On these bases, we generated a library by fast assembling phenothiazine, biphenyl and phenylpiperazine privileged fragments via a Huisgen cycloaddition. Thanks to available screening facilities, the library was screened for activity against Trypanosoma brucei and cruzi, Leishmania infantum and donovani, for selectivity against mammalian cells, and for ADME-Tox properties. Despite the small number of synthesized compounds, this strategy led to the successful identification of interesting hits with promising profiles. Another extraordinary possibility is the development of new drugs based on food industry wastes as sustainable starting materials. Toward this aim, we developed a series of novel T. brucei hits obtained by combining a 2-phenoxy-1,4-naphthoquinone scaffold with phenolic constituents from the cashew nut shell liquid (CNSL), a by-product and a pollutant from cashew nut processing factories. We envisage that such compounds, easily obtained from a waste material produced in high quantity in the endemic countries, might be ethically, environmentally and economically sustainable starting point for the development of new anti-trypanosomatid drugs.
  • Multicomponent reactions: A mighty journey partner for infectious tropical
           disease drug discovery
    • Abstract: Publication date: Available online 17 June 2019Source: Annual Reports in Medicinal ChemistryAuthor(s): Diego Muñoz-Torrero, Rodolfo Lavilla, F. Javier Pérez-Areales, Ouldouz GhashghaeiAbstractInfectious tropical diseases such as malaria, tuberculosis, and the so-called neglected tropical diseases are causing tremendous suffering to millions of people and huge impact on national economies, seriously worsening life conditions in the poorest parts of the world, where these diseases are endemic. Despite the existence of drugs for most of these diseases, they are far from adequate. Lack of efficacy, toxicity, and emergence of pathogen resistance are among the most important flaws of currently available drugs. Thus, apart from improving prevention and vector control measures, there is an urgent need for developing new efficacious, safe, and inexpensive drugs that desirably feature novel chemotypes. Multicomponent reactions (MCRs), where three or more reactants are combined in a one-pot reaction, constitute a very powerful tool for such endeavors, inasmuch as they enable a very rapid access to structurally diverse, usually complex scaffolds, shortening the synthesis of the novel drugs and, hence, lowering production costs, and affording original chemotypes. In this chapter, we provide an overview of the application of different types of MCRs to drug discovery against infectious tropical diseases, with particular emphasis on how structural complexity and molecular diversity can be readily introduced through their use.
  • Inhibitors of enzymes in the electron transport chain of Mycobacterium
    • Abstract: Publication date: Available online 8 June 2019Source: Annual Reports in Medicinal ChemistryAuthor(s): Andrew M. Thompson, William A. DennyAbstractThe increasing prevalence of drug resistant tuberculosis has created an urgent need for new antibiotics with novel modes of action. New drug targets include various enzymes in the electron transport pathway that are critical for maintaining growth and survival of the causative bacterium. Following approval of the ATP synthase inhibitor bedaquiline, a large number of compounds with activity against these enzymes have been identified, and a few drug candidates were recently developed that are close to or have already commenced clinical trials. Such progress is indeed promising, although the predominant focus on just three targets (NADH dehydrogenase-2, QcrB in the cytochrome bc1-aa3 supercomplex, and ATP synthase) may need to be reconsidered in light of recent findings. In this chapter, we briefly review the role of each enzyme and summarize the key results for each inhibitor class.
  • The hybrid antimalarial approach
    • Abstract: Publication date: Available online 8 June 2019Source: Annual Reports in Medicinal ChemistryAuthor(s): Princy Gupta, Lovepreet Singh, Kamaljit SinghAbstractThe incidence and prevalence of malaria presents a much worrying trend and seems to negate the global efforts to control malarial infection. This is in part attributed to a smaller number of antimalarials agents as well as emergence of resistance to the most available antimalarial drugs. Hybrid approach encompassing rational antimalarial drug design involving covalent linking of two pharmacophores into a single molecule has come up as an attractive tool, which could offer advantages such as increased (dual) activity, dosage compliance, countering resistance etc. In this chapter, we have presented update on pyrimidine-based hybrid antiplasmodial agents.
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