Subjects -> MEDICAL SCIENCES (Total: 8529 journals)
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MEDICAL SCIENCES (2342 journals)                  1 2 3 4 5 6 7 8 | Last

Showing 1 - 200 of 3562 Journals sorted alphabetically
16 de Abril     Open Access   (Followers: 3)
3D Printing in Medicine     Open Access   (Followers: 5)
4 open     Open Access  
AADE in Practice     Hybrid Journal   (Followers: 6)
AAS Open Research     Open Access  
ABCS Health Sciences     Open Access   (Followers: 9)
Abia State University Medical Students' Association Journal     Full-text available via subscription   (Followers: 2)
AboutOpen     Open Access  
ACIMED     Open Access   (Followers: 1)
ACS Medicinal Chemistry Letters     Hybrid Journal   (Followers: 48)
Acta Bio Medica     Full-text available via subscription   (Followers: 2)
Acta Bioethica     Open Access  
Acta Bioquimica Clinica Latinoamericana     Open Access   (Followers: 1)
Acta Científica Estudiantil     Open Access  
Acta Facultatis Medicae Naissensis     Open Access   (Followers: 1)
Acta Herediana     Open Access  
Acta Informatica Medica     Open Access  
Acta Medica (Hradec Králové)     Open Access  
Acta Medica Bulgarica     Open Access  
Acta Medica Colombiana     Open Access   (Followers: 1)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Medica Indonesiana     Open Access  
Acta Medica International     Open Access  
Acta medica Lituanica     Open Access  
Acta Medica Marisiensis     Open Access  
Acta Medica Martiniana     Open Access  
Acta Medica Nagasakiensia     Open Access   (Followers: 1)
Acta Medica Peruana     Open Access   (Followers: 2)
Acta Médica Portuguesa     Open Access  
Acta Medica Saliniana     Open Access  
Acta Scientiarum. Health Sciences     Open Access   (Followers: 2)
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 6)
Acupuncture and Natural Medicine     Open Access  
Addiction Science & Clinical Practice     Open Access   (Followers: 8)
Addictive Behaviors Reports     Open Access   (Followers: 9)
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / Health Sciences Journal of Adıyaman University     Open Access   (Followers: 1)
Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi     Open Access   (Followers: 1)
Advanced Biomedical Research     Open Access  
Advanced Health Care Technologies     Open Access   (Followers: 10)
Advanced Science, Engineering and Medicine     Partially Free   (Followers: 9)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Bioscience and Clinical Medicine     Open Access   (Followers: 8)
Advances in Cell and Gene Therapy     Hybrid Journal   (Followers: 2)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 27)
Advances in Clinical Radiology     Full-text available via subscription   (Followers: 2)
Advances in Life Course Research     Hybrid Journal   (Followers: 10)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Medical Education and Practice     Open Access   (Followers: 32)
Advances in Medical Ethics     Open Access   (Followers: 1)
Advances in Medical Research     Open Access   (Followers: 2)
Advances in Medical Sciences     Hybrid Journal   (Followers: 9)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Medicine     Open Access   (Followers: 3)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 5)
Advances in Molecular Oncology     Open Access   (Followers: 2)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7)
Advances in Parkinson's Disease     Open Access   (Followers: 1)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Preventive Medicine     Open Access   (Followers: 6)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20)
Advances in Regenerative Medicine     Open Access   (Followers: 3)
Advances in Skeletal Muscle Function Assessment     Open Access  
Advances in Therapy     Hybrid Journal   (Followers: 5)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 2)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 15)
Advances in Virus Research     Full-text available via subscription   (Followers: 6)
Advances in Wound Care     Hybrid Journal   (Followers: 14)
Aerospace Medicine and Human Performance     Full-text available via subscription   (Followers: 13)
African Health Sciences     Open Access   (Followers: 4)
African Journal of Biomedical Research     Open Access   (Followers: 1)
African Journal of Clinical and Experimental Microbiology     Open Access   (Followers: 4)
African Journal of Laboratory Medicine     Open Access   (Followers: 2)
African Journal of Medical and Health Sciences     Open Access   (Followers: 3)
African Journal of Thoracic and Critical Care Medicine     Open Access  
African Journal of Trauma     Open Access   (Followers: 1)
Afrimedic Journal     Open Access   (Followers: 2)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 9)
AJOB Empirical Bioethics     Hybrid Journal   (Followers: 3)
AJSP: Reviews & Reports     Hybrid Journal  
Aktuelle Ernährungsmedizin     Hybrid Journal   (Followers: 4)
Al-Azhar Assiut Medical Journal     Open Access   (Followers: 2)
Al-Qadisiah Medical Journal     Open Access   (Followers: 1)
Alerta : Revista Científica del Instituto Nacional de Salud     Open Access  
Alexandria Journal of Medicine     Open Access   (Followers: 1)
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 3)
Alpha Omegan     Full-text available via subscription  
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 2)
Althea Medical Journal     Open Access   (Followers: 2)
American Journal of Biomedical Engineering     Open Access   (Followers: 15)
American Journal of Biomedical Research     Open Access   (Followers: 2)
American Journal of Biomedicine     Full-text available via subscription   (Followers: 7)
American Journal of Chinese Medicine, The     Hybrid Journal   (Followers: 4)
American Journal of Clinical Medicine Research     Open Access   (Followers: 8)
American Journal of Family Therapy     Hybrid Journal   (Followers: 10)
American Journal of Law & Medicine     Full-text available via subscription   (Followers: 12)
American Journal of Lifestyle Medicine     Hybrid Journal   (Followers: 6)
American Journal of Managed Care     Full-text available via subscription   (Followers: 12)
American Journal of Medical Case Reports     Open Access   (Followers: 1)
American Journal of Medical Sciences and Medicine     Open Access   (Followers: 4)
American Journal of Medicine     Hybrid Journal   (Followers: 51)
American Journal of Medicine and Medical Sciences     Open Access   (Followers: 1)
American Journal of Medicine Studies     Open Access   (Followers: 3)
American Journal of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American Journal of the Medical Sciences     Hybrid Journal   (Followers: 12)
American Journal on Addictions     Hybrid Journal   (Followers: 10)
American medical news     Free   (Followers: 3)
American Medical Writers Association Journal     Full-text available via subscription   (Followers: 6)
Amyloid: The Journal of Protein Folding Disorders     Hybrid Journal   (Followers: 5)
Anales de la Facultad de Medicina     Open Access  
Anales de la Facultad de Medicina, Universidad de la República, Uruguay     Open Access  
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1)
Analgesia & Resuscitation : Current Research     Hybrid Journal   (Followers: 6)
Anatolian Clinic the Journal of Medical Sciences     Open Access  
Anatomica Medical Journal     Open Access  
Anatomical Science International     Hybrid Journal   (Followers: 3)
Anatomical Sciences Education     Hybrid Journal   (Followers: 2)
Anatomy     Open Access   (Followers: 3)
Anatomy Research International     Open Access   (Followers: 4)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3)
Ankara Medical Journal     Open Access   (Followers: 2)
Ankara Üniversitesi Tıp Fakültesi Mecmuası     Open Access  
Annales de Pathologie     Full-text available via subscription  
Annales des Sciences de la Santé     Open Access  
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 3)
Annals of African Medicine     Open Access   (Followers: 2)
Annals of Anatomy - Anatomischer Anzeiger     Hybrid Journal   (Followers: 3)
Annals of Bioanthropology     Open Access   (Followers: 5)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 19)
Annals of Biomedical Sciences     Full-text available via subscription   (Followers: 4)
Annals of Clinical Hypertension     Open Access  
Annals of Clinical Microbiology and Antimicrobials     Open Access   (Followers: 14)
Annals of Family Medicine     Open Access   (Followers: 15)
Annals of Health Research     Open Access   (Followers: 1)
Annals of Ibadan Postgraduate Medicine     Open Access  
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Medicine     Hybrid Journal   (Followers: 12)
Annals of Medicine and Surgery     Open Access   (Followers: 7)
Annals of Microbiology     Hybrid Journal   (Followers: 13)
Annals of Musculoskeletal Medicine     Open Access   (Followers: 1)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Rehabilitation Medicine     Open Access  
Annals of Saudi Medicine     Open Access  
Annals of the College of Medicine, Mosul     Open Access   (Followers: 1)
Annals of the New York Academy of Sciences     Hybrid Journal   (Followers: 5)
Annals of The Royal College of Surgeons of England     Full-text available via subscription   (Followers: 3)
Annals of the RussianAacademy of Medical Sciences     Open Access  
Annual Reports in Medicinal Chemistry     Full-text available via subscription   (Followers: 7)
Annual Reports on NMR Spectroscopy     Full-text available via subscription   (Followers: 5)
Annual Review of Medicine     Full-text available via subscription   (Followers: 18)
Anthropological Review     Open Access   (Followers: 24)
Anthropologie et santé     Open Access   (Followers: 5)
Antibiotics     Open Access   (Followers: 9)
Antibodies     Open Access   (Followers: 2)
Antibody Reports     Open Access  
Antibody Technology Journal     Open Access   (Followers: 1)
Antibody Therapeutics     Open Access  
Anuradhapura Medical Journal     Open Access  
Anwer Khan Modern Medical College Journal     Open Access   (Followers: 2)
Apmis     Hybrid Journal   (Followers: 2)
Apparence(s)     Open Access   (Followers: 1)
Applied Clinical Informatics     Hybrid Journal   (Followers: 4)
Applied Clinical Research, Clinical Trials and Regulatory Affairs     Hybrid Journal   (Followers: 2)
Applied Medical Informatics     Open Access   (Followers: 14)
Arab Journal of Nephrology and Transplantation     Open Access   (Followers: 1)
Archive of Biomedical Science and Engineering     Open Access   (Followers: 1)
Archive of Clinical Medicine     Open Access   (Followers: 1)
Archive of Community Health     Open Access   (Followers: 1)
Archives Medical Review Journal / Arşiv Kaynak Tarama Dergisi     Open Access  
Archives of Asthma, Allergy and Immunology     Open Access  
Archives of Clinical Hypertension     Open Access   (Followers: 1)
Archives of Medical and Biomedical Research     Open Access   (Followers: 3)
Archives of Medical Laboratory Sciences     Open Access   (Followers: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 4)
Archives of Medicine and Surgery     Open Access  
Archives of Organ Transplantation     Open Access   (Followers: 1)
Archives of Preventive Medicine     Open Access   (Followers: 1)
Archives of Pulmonology and Respiratory Care     Open Access   (Followers: 1)
Archives of Renal Diseases and Management     Open Access   (Followers: 1)
Archives of Trauma Research     Open Access   (Followers: 4)
Archivos de Medicina (Manizales)     Open Access  
ArgoSpine News & Journal     Hybrid Journal  
Arquivos Brasileiros de Oftalmologia     Open Access   (Followers: 1)
Arquivos de Ciências da Saúde     Open Access  
Arquivos de Medicina     Open Access  
Ars Medica : Revista de Ciencias Médicas     Open Access  
ARS Medica Tomitana     Open Access   (Followers: 1)
Art Therapy: Journal of the American Art Therapy Association     Hybrid Journal   (Followers: 18)
Arterial Hypertension     Open Access   (Followers: 1)
Artificial Intelligence in Medicine     Hybrid Journal   (Followers: 18)
Artificial Organs     Hybrid Journal   (Followers: 1)
ASHA Leader     Open Access   (Followers: 3)
Asia Pacific Family Medicine Journal     Open Access   (Followers: 2)
Asia Pacific Journal of Clinical Nutrition     Full-text available via subscription   (Followers: 13)
Asia Pacific Journal of Clinical Trials : Nervous System Diseases     Open Access  
Asian Bioethics Review     Full-text available via subscription   (Followers: 3)
Asian Biomedicine     Open Access   (Followers: 2)
Asian Journal of Cell Biology     Open Access   (Followers: 6)
Asian Journal of Health     Open Access   (Followers: 3)

        1 2 3 4 5 6 7 8 | Last

Similar Journals
Journal Cover
Advances in Medical Sciences
Journal Prestige (SJR): 0.694
Citation Impact (citeScore): 2
Number of Followers: 9  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1896-1126 - ISSN (Online) 1898-4002
Published by Elsevier Homepage  [3203 journals]
  • Clarithromycin effectively enhances doxorubicin-induced cytotoxicity and
           apoptosis in MCF7 cells through dysregulation of autophagy
    • Abstract: Publication date: September 2020Source: Advances in Medical Sciences, Volume 65, Issue 2Author(s): Nahid Amani, Mohammad Shokrzadeh, Fatemeh Shaki
       
  • He said, she said: Sex differences in peripheral artery disease
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Shahbaz A. Malik, Andrew M. Goldsweig
       
  • Auditory evoked potentials might have the potential to serve as early
           indicators related to amyloid beta peptide toxicity
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Enis Hidisoglu, Piraye Yargicoglu
       
  • Geographic disparities in the application of endovascular repair of
           unruptured abdominal aortic aneurysm - Polish population analysis
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Bartosz Symonides, Andrzej Śliwczyński, Zbigniew Gałązka, Jarosław Pinkas, Zbigniew Gaciong
       
  • Treatment and its side effects in ANCA-associated vasculitides – Study
           based on POLVAS registry data
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Grzegorz Biedroń, Anna Włudarczyk, Katarzyna Wawrzycka-Adamczyk, Krzysztof Wójcik, Jan Sznajd, Zbigniew Zdrojewski, Anna Masiak, Zenobia Czuszyńska, Maria Majdan, Radosław Jeleniewicz, Marian Klinger, Katarzyna Jakuszko, Olumide Olatubosun Rowaiye, Marek Brzosko, Iwona Brzosko, Alicja Dębska-Ślizień, Hanna Storoniak, Witold Tłustochowicz, Joanna Kur-Zalewska, Małgorzata Wisłowska
       
  • Total blood lymphocyte count as a prognostic factor among unselected
           inpatients
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Krzysztof Tojek, Wioletta Banaś, Beata Czerniak, Gabriel Kowalczyk, Beata Szukay, Wanda Korzycka-Wilińska, Zbigniew Banaszkiewicz, Jacek Budzyński
       
  • Comparative effectiveness of 8 versus 12 weeks of
           Ombitasvir/Paritaprevir/ritonavir and Dasabuvir in treatment-naïve
           
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Dorota Zarębska-Michaluk, Anna Piekarska, Jerzy Jaroszewicz, Jakub Klapaczyński, Włodzimierz Mazur, Rafał Krygier, Teresa Belica-Wdowik, Barbara Baka-Ćwierz, Ewa Janczewska, Paweł Pabjan, Beata Dobracka, Beata Lorenc, Magdalena Tudrujek-Zdunek, Krzysztof Tomasiewicz, Marek Sitko, Aleksander Garlicki, Agnieszka Czauż-Andrzejuk, Jolanta Citko, Dorota Dybowska, Waldemar Halota
       
  • Value of magnetic resonance enterography in diagnosis and treatment follow
           up in Crohn’s disease in children
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Elżbieta Krzesiek, Ewa Nienartowicz, Barbara IwańczakAbstractPurposeCrohn’s disease (CD) is a chronic inflammatory disease which can affect all parts of the gastrointestinal tract. Magnetic resonance enterography (MRE) enables detection of pathologic changes in the small intestine, which are not accessible by conventional endoscopy. The aim of the study was to assess the value of MRE in imaging of small bowel lesions, their location and extent, in CD patients and its correlation with clinical and endoscopic activity.Materials and methodsMRE was performed in 108 children with CD, aged 5.5 to 18 years. The diagnosis was based on the Porto criteria. Location and clinical manifestation was evaluated according to the Paris classification. Clinical CD activity was assessed with PCDAI and endoscopic activity with SES-CD. In 36 children, control MRE was performed.ResultsThe most common endoscopic location of the disease was the colon (41.7%), terminal ileum and colon (24.1%). Inflammation as the main clinical manifestation was dominant (81.5%). In MRE, inflammatory changes were found in 40.8% of children, strictures in 11.1%. The EIA value (activity in MRE) increased along with PCDAI score and SES-CD. MRE performed during follow up, showed transmural healing in 16.7% of patients and improvement in 55.5%.ConclusionsMRE is an efficient diagnostic tool in proper characterization of disease location in pediatric CD. As positive correlation of the results of MRE with the endoscopic and clinical activity has been found, taking into account good tolerance and non-invasiveness of the procedure it can be recommended to be used in reassessment.
       
  • Role of Apelin/APJ axis in cancer development and progression
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Javad Masoumi, Abdollah Jafarzadeh, Hossein Khorramdelazad, Morteza Abbasloui, Jalal Abdolalizadeh, Najmeh JamaliAbstractApelin is an endogenous peptide, which is expressed in a vast board of organs such as the brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The apelin receptor, called angiotensin-like-receptor 1 (APJ), is also expressed in the brain, spleen, placenta, heart, liver, intestine, prostate, thymus, testis, ovary, lungs, kidneys, stomach, and adipose tissue. The apelin/APJ axis is involved in a number of physiological and pathological processes. The apelin expression is increased in various kinds of cancer and the apelin/APJ axis plays a key role in the development of tumors through enhancing angiogenesis, metastasis, cell proliferation and also through the development of cancer stem cells and drug resistance. The apelin also stops the apoptosis of cancer cells. The apelin/APJ axis was considered in this review as an attractive therapeutic target for cancer treatment.
       
  • Gender differences and long-term clinical outcomes in patients with
           chronic total occlusions of infrainguinal lower limb arteries treated from
           retrograde access with peripheral vascular interventions
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Artur Pawlik, Rafał Januszek, Zoltan Ruzsa, Viktor Óriás, Paweł Kleczyński, Joanna Wojtasik-Bakalarz, Saleh Arif, Andras Nyerges, Michał Chyrchel, Agata Stanek, Dariusz Dudek, Stanisław BartuśAbstractPurposeWe sought to investigate gender-related differences in clinical outcomes after peripheral vascular interventions (PVIs) from retrograde access in patients with chronic total occlusions (CTOs) of the infrainguinal arteries.Patients and methodsA total of 939 consecutive patients undergoing PVI were enrolled in the study. Patients with peripheral artery diseases (PAD) and CTOs were treated with PVI from retrograde access according to the local protocol. The participants were divided according to gender. Retrograde access included distal puncturing to reach the CTO. The mean follow-up lasted 1,144.9 ± 664.3 days. Baseline characteristics, procedural and long-term outcomes were compared according to gender.ResultsWomen represented 37.4% of the study population, and more frequently suffered from hypertension (92% vs. 86%, p = 0.001) and diabetes (54% vs. 46%, p = 0.02). Males more often presented with chronic obstructive pulmonary disease (14.8% vs. 6.8%, p = 0.0003), coronary artery disease (45.4% vs. 32.7%, p = 0.0001), smoking (60.4% vs. 45%, p = 0.007) and prior PVI (25% vs. 17%, p = 0.005). The Kaplan-Meier survival curves at 5 years did not reveal gender-related differences in mortality (p = 0.8), whereas men were at a significantly higher risk of re-PVI during the follow-up period (p = 0.047). Male gender was an independent predictor of re-PVI (Hazard ratio: 1.276; 95% confidence interval: 1.015–1.614, p = 0.03).ConclusionMales are at increased risk of re-PVI compared to females with PAD and CTOs of infrainguinal arteries treated with PVI from retrograde access.
       
  • Sexual disorders and dyspnoea among women with obstructive sleep apnea
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Szymon Skoczyński, Krzysztof Nowosielski, Łukasz Minarowski, Grzegorz Brożek, Aleksandra Oraczewska, Klaudia Glinka, Karolina Ficek, Beata Kotulska, Ewelina Tobiczyk, Robert Skomro, Robert Mróz, Adam BarczykAbstractPurposeWe aimed to assess sexual function, sexual distress and the prevalence of female sexual dysfunction (FSD) among women with obstructive sleep apnea syndrome (OSA), and to assess if the presence of OSA and dyspnea influences the prevalence of FSD, body image during sexual activity and sexual function.MethodsWe assessed 23 women with new OSA diagnosis and 23 healthy age and body mass index (BMI) matched controls. Sexual functions were evaluated by Changes in Sexual Functioning Questionnaire (CSFQ), sexual dysfunction was diagnosed based on DSM-5 criteria during the semi-structured sexual interview, whereas body image was evaluated by Body Exposure during Sexual Activities Questionnaire (BESAQ). New York Heart Association score (NYHA) and Visual Analogue Scale (VAS) were used to assess dyspnea.ResultsOSA women had worse general sexual function and lower frequency of desire assessed by CSFQ (37.0 vs. 42 and 5 vs. 6), were at higher risk for FSD (CSFQ; 80% vs. 48%) and had a higher NYHA score (II vs. I). The prevalence of FSD did not differ in both groups, nor did sexual dysfunctions or body image (BESAQ). The multiple regression analysis revealed that OSA was associated with lower desire/frequency, higher NYHA scores with decreased desire/interest and worse body image during sexual activity, whereas higher VAS scores with worse desire/frequency.ConclusionsOSA probably does not influence the prevalence of sexual dysfunction in females. However, OSA, as well as the higher level of dyspnea assessed by NYHA, may decrease sexual body image and sexual performance in females.
       
  • The effect of medical treatment on nasal exhaled nitric oxide (NO) in
           patients with persistent allergic rhinitis: A randomized control study
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Anh Vo-Thi-Kim, Tan Van-Quang, Binh Nguyen-Thanh, Dung Dao-Van, Sy Duong-QuyAbstractPurposeThis study aimed to evaluate the role of nasal nitric oxide (NO) in the management of patients with persistent allergic rhinitis (PER).MethodsIt was a randomized and comparative study. The study subjects were classified as controls (healthy subjects) or patients with PER based on defined criteria. All clinical, functional and biological data were collected for analyzing. Nasal fractional exhaled nitric oxide (FENO) was measured by electroluminescence device. Patients with PER were randomized for treatment with antihistamine (ATH) combined with leukotriene receptor antagonists (LRA) or only with intranasal steroids (INS).ResultsDuring two years, 501 subjects were included: 234 control subjects and 267 patients with PER. The levels of nasal NO, total IgE, blood eosinophil counts, and apnea-hypopnea index (AHI) in patients with PER were higher than controls (P 
       
  • Plasma level of laminin 5 and collagen IV in cryptorchidism
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Marta Komarowska, Beata Szymańska, Łukasz Ołdak, Anna Sankiewicz, Ewa Matuszczak, Ewa Gorodkiewicz, Wojciech Debek, Robert Milewski, Adam HermanowiczAbstractPurposeLaminin 5 and collagen IV are the main compounds of the extracellular matrix of the germinal epithelium. The purpose of this study was to evaluate the concentration of these two markers of fibrosis in the plasma of boys with congenital unilateral cryptorchidism.Materials and methodsThe study group comprised 43 boys aged 1–3 years with congenital unilateral cryptorchidism. The control group included 54 healthy, age matched boys, admitted for planned hernioplasty. To assess laminin 5 and collagen IV in the plasma of boys with unilateral cryptorchidism, we used a new biosensor with Surface Plasmon Resonance Imaging technique detection.ResultsThe median concentration of laminin 5 and collagen IV in the serum of boys with congenital, unilateral cryptorchidism was higher than in boys with normal scrotal testis. The difference was statistically significant (p 
       
  • Single-cell analysis on stromal fibroblasts in the microenvironment of
           solid tumours
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Marahaini MusaAbstractBesides malignant cells, the tumour microenvironment consists of various stromal cells such as cancer-associated fibroblasts (CAFs) and myofibroblasts. Accumulation of heterogeneous populations of stromal cells in solid tumours is associated with lower survival rates and cancer recurrence in patients. Certain limitations presented by conventional experimental designs and techniques in cancer research have led to poor understanding of the fundamental basis of cancer niche. Recent developments in single-cell techniques allow more in-depth studies of the tumour microenvironment. Analyses at the single-cell level enables the detection of rare cell types, characterization of intra-tumour cellular heterogeneity and analysis of the lineage output of malignant cells. This subsequently, provides valuable insights on better diagnostic methods and treatment avenues for cancer. This review explores the recent advancements and applications of single-cell technologies in cancer research pertaining to the study of stromal fibroblasts in the microenvironment of solid tumours.
       
  • Influence of infiltration anaesthesia on perioperative outcomes following
           lumbar discectomy under surgical pleth index-guided general anaesthesia: A
           preliminary report from a randomised controlled prospective trial
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Michał Stasiowski, Anna Missir, Aleksandra Pluta, Izabela Szumera, Małgorzata Stasiak, Wojciech Szopa, Bartłomiej Błaszczyk, Bartłomiej Możdżyński, Krzysztof Majchrzak, Michał Tymowski, Ewa Niewiadomska, Piotr Ładziński, Lech Krawczyk, Wojciech KasperaAbstractPurposeSevere postoperative pain (SPP) may occur after lumbar discectomy. To prevent SPP and reduce rescue opioid consumption, infiltration anaesthesia (IA) has been combined with general anaesthesia (GA). This study verified how GA combined with IA facilitated intra- and postoperative demand for opioids and affected the incidence of SPP in patients subjected to open lumbar discectomy.Materials/methodsNinety-nine patients undergoing lumbar discectomy under GA with Surgical Pleth Index (SPI)-guided fentanyl (FNT) administration were randomly assigned to receive IA combined with either 0.2% bupivacaine (BPV) or 0.2% ropivacaine (RPV) with FNT 50 μg and compared with controls (BF, RF, and C groups, respectively).ResultsNinety-four patients were included in the final analysis. Adjusted according to SPI, total intraoperative FNT dosages did not differ between the study groups (p = 0.23). The proportion of patients who reported SPP was the highest in group C (41.9%) than in the RF (12.9%) and BF groups (31.3%) (p 
       
  • Mechanism of pro-apoptotic action of prosthetic restorations on oral
           mucosa cells
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Natalia Domian, Arkadiusz Surażyński, Janusz Szarmach, Żaneta Piotrowska, Irena KasackaAbstractPurposeThe aim of this study was to check the pro-apoptotic mechanism of prosthetic reconstruction on epithelial cells of the oral mucosa.Patients and methodsThe research was carried out on the saliva of healthy patients using prostheses. The sample swabs were stained using the May-Grünwald-Giemsa method and processed by immunohistochemistry for nuclear factor kappa B (NF-κB; p65) and caspase-3. Western blots were used to detect caspase-3, NF-κB, p53 and COX-2 expression.ResultsWe found an increased expression of caspase-3, NF-κB and p53 in the oral epithelial cells of patients using prosthetic restorations compared to the subjects from the control group. No differences in COX-2 expression were found between the groups. The strongest immunoreactivity and expression of caspase-3, NF-κB and p53 were observed in patients using full prosthesis for less than two years.ConclusionsThe results of the conducted research indicate that prosthetic restorations may affect the process of apoptosis of oral mucosa epithelial cells. Lack of difference in expression of COX-2 in the saliva of the studied patients suggests that apoptosis is not caused by inflammatory factors.
       
  • Nasal nitric oxide in upper airways in children with asthma and allergic
           rhinitis
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Sabina Galiniak, Marek Biesiadecki, David Aebisher, Marta RachelAbstractPurposeThe aim of this study is to compare levels of nasal nitric oxide (nNO) in pediatric patients with respiratory diseases.Materials and methodsnNO was measured by an electrochemical analyzer in 179 patients aged 7–15 with asthma, allergic rhinitis or with asthma and allergic rhinitis and in healthy children recruited from a local allergology clinic. Correlations between nNO levels and patient clinical parameters were assessed.ResultsnNO was significantly higher in patients with allergic rhinitis (2316.3 ± 442.33 ppb, p < 0.001) as well as with asthma and allergic rhinitis (2399.9 ± 446.73 ppb, p < 0.001) compared to asthmatic and healthy children (1066.4 ± 416.75; 836.2 ± 333.47 ppb, respectively). A receiver operating characteristic curve analysis revealed that a cut-off value of 1545 ppb nNO and 1459 ppb nNO has sensitivity of 100% and specificity of 100% in distinguishing allergic rhinitis and combined asthma and allergic rhinitis from healthy subjects. A positive correlation between nNO and age and height was determined only in groups of healthy controls. We found no association between nNO level and clinical parameters including percent of eosinophils and total IgE.ConclusionLevels of nNO are currently measured by different analyzers and with different methods, so assessment of nNO is in need of standardization improvement to become a more reliable tool. However, because it is cheap, painless and fast, it may be helpful in combination with recognition of clinical symptoms and typical diagnostic methods, especially in estimation of inflammation.
       
  • Changes in circulating endothelial microvesicles in men after myocardial
           infarction
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Vytautas Žėkas, Rėda Matuzevičienė, Dovilė Karčiauskaitė, Dalius Vitkus, Mantas Radzevičius, Aušra Janiulionienė, Aušra Linkevičiūtė, Sandra Kutkienė, Zita KučinskienėAbstractPurposeThe objective of the study was to determine the differences in the numbers of endothelial microvesicles (EMV) after myocardial infarction (MI) and their association with oxidative stress.Materials and methodsWe included 15 post MI patients and 28 healthy controls. Samples were analysed by flow cytometry. We examined four EMV populations: 1) CD144+, CD42a-, CD61−, 2) CD144+, CD42a+, CD61−, 3) CD105+, CD42a-, CD61−and 4) CD31+, CD42a-, CD61−and determined a percentage of CD62e + EMV. Malondialdehyde concentration was determined by ultra-high performance liquid chromatography.ResultsThe median of EMV counts differed between controls and patients in: CD105+ (10.91 microvesicles/μl vs. 33.68 microvesicles/μl, P = 0.006), CD144+, CD42a+ (312.87 microvesicles/μl vs. 73.29 microvesicles/μl, P 
       
  • Specific overexpression of 15-lipoxygenase in endothelial cells promotes
           cancer cell death in an in vivo Lewis lung carcinoma mouse model
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Maya Sultan, Dikla Ben-Shushan, Michael Peled, Yehuda Kamari, Shulamit Isman, Iris Barshack, Ralf-Jürgen Kuban, Hartmut Kühn, Dror Harats, Aviv ShaishAbstractPurposeLipoxygenases (LOX) have been implicated in carcinogenesis, however both pro- and anti-carcinogenic effects have been reported in different cancer models. Using transgenic mice, which specifically overexpress human 15-lipoxygenase (ALOX15) in endothelial cells (EC), we previously demonstrated significant inhibition of tumor development. In the Lewis lung carcinoma (LLC) model, the primary tumor developed similarly in both wild type (WT) and ALOX15 overexpressing mice. However, metastases development was significantly inhibited in the transgenic mice. Here, we explored the molecular basis for the anti-metastatic effect of endothelial cell specific ALOX15 overexpression.Materials/methodsWe used ALOX15 overexpressing mice, and in-vitro cell model to evaluate the molecular effect of ALOX15 on EC and LLC cells.ResultsWhen LLC cells were injected in WT and ALOX15 overexpressing mice, we observed a higher degree of apoptosis and necrosis in primary and metastatic tumors of ALOX15 overexpressing animals. These anti-carcinogenic and anti-metastatic effects were paralleled by augmented expression of cyclin-dependent kinase inhibitor 1A (CDKN1A; p21) and of the peroxisome proliferators-activated receptor (PPAR)γ and by downregulation of the steady state concentrations of connexin26 mRNA. Consistent with these in vivo effects, ALOX15 overexpression in LLC and HeLa cancer cells in vitro significantly reduced cell viability in culture. In contrast, similar treatment of non-cancerous B2B epithelial cells did not impact cell viability.ConclusionsTaken together, our data suggests that endothelial cell specific overexpression of ALOX15 promotes apoptosis and necrosis in primary and metastatic tumors in mice, by upregulation of P21 and PPARγ expression in adjacent cancer cells.
       
  • Chemokines profile in patients with chronic heart failure treated with
           cardiac resynchronization therapy
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Katarzyna Ptaszynska-Kopczynska, Emilia Sawicka, Marta Marcinkiewicz-Siemion, Ewa Tarasiuk, Anna Lisowska, Anna Szpakowicz, Marcin Witkowski, Marcin Kaminski, Karol Charkiewicz, Piotr Laudanski, Miroslaw Charkiewicz, Wlodzimierz J. Musial, Karol A. KaminskiAbstractPurposeInflammatory mechanisms have been suggested to play a role in the heart failure with reduced ejection fraction (HF-REF) development, but the role of chemokines is largely unknown. Cardiac resynchronization therapy (CRT) may reverse the HF-REF course.We aimed to evaluate selected chemokines concentrations in HF-REF patients and their relationship with disease severity and clinical response to CRT.Materials and methodsThe study included 37 patients (64.1 ± 11.04 years, 6 females) with HF-REF subjected to CRT, controlled prior to implantation and after 6 months. The control population included 26 healthy volunteers (63.9 ± 8.1 years, 8 females). Serum chemokines concentrations were determined using multiplex method.ResultsHF-REF patients were characterized by the higher baseline MIF, NAP-2 and PF4 concentrations and lower Axl, BTC, IL-9, and IL-18 BPa concentrations comparing to controls. After 6 months of CRT only NAP-2 concentration decreased significantly in comparison to the baseline values.ConclusionsHF-REF patients present altered chemokines profile compared to the control group. The CRT-related alleviation of HF-REF causes only slight changes in the chemokines concentrations especially in the platelet-associated ones. The precise chemokines role in the HF-REF pathogenesis and their prognostic value remains to be established.
       
  • Elevated levels of d-dimer are associated with inflammation and disease
           activity rather than risk of venous thromboembolism in patients with
           granulomatosis with polyangiitis in long term observation
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Anna Borowiec, Rafał Dąbrowski, Ilona Kowalik, Tomasz Rusinowicz, Małorzata Hadzik-Błaszczyk, Renata Krupa, Katarzyna ŻycińskaAbstractPurposeGranulomatosis with polyangiitis (GPA) is one of antineutrophil cytoplasmic autoantibody (ANCA) - associated vasculitis. The disease is characterized by necrotizing inflammation of small vessels causing tissue ischemia in a variety of organs. The aim of the present study was an evaluation of inflammation, coagulation and fibrinolysis biomarkers, and their possible associations with various clinical and laboratory parameters in GPA patients.MethodsA group of 100 consecutive patients with GPA were prospectively followed in the study. In all patients, echocardiography and laboratory tests were performed.ResultsThe patients were followed-up for a median of 4.0 ± 1.9 years. Circulating d-dimer concentrations were elevated in a majority (56%) of GPA patients, and were significantly higher in GPA patients in the active stage compared to those in remission (median 652 vs. 405 ng/ml, p = 0.0002). In 23 patients (23%) venous thromboembolism (VTE) was diagnosed during observation. However, there were no differences in d-dimer concentrations between patients with and without VTE either in active stage or in remission. Correlation analysis showed that the levels of d-dimer correlated with hs-CRP (r = 0.42, p 
       
  • Proven and unproven methods for diagnosis and treatment of infertility
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Marian Szamatowicz, Jacek SzamatowiczAbstractInfertility and subfertility affect a significant part of the population. Among various definitions of this pathology, the most common one is provided by the World Health Organisation; it says that infertility is ‘a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourses’. The global prevalence of infertility is about 50–70 million couples. Since the process of human reproduction involves a large number of factors, a broad spectrum of infertility tests might be applied. Some of the tests focus directly on the pregnancy, some are only partially effective, whereas others should not be recommended for infertile couples. The aim of this review is to present a critical evaluation of the infertility diagnostic process and to discuss the recommendations for its most effective treatment.
       
  • Antibody-free rapid diagnosis of malaria in whole blood with
           surface-enhanced Raman Spectroscopy using Nanostructured Gold Substrate
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Wei Wang, Rui-ling Dong, Dayong Gu, Jian-an He, Pin Yi, Siu-Kai Kong, Ho-Pui Ho, Jacky Fong-Chuen Loo, Wen Wang, Qian WangAbstractPurposeThe aim of this study is to establish a rapid antibody-free diagnostic method of malaria infection with Plasmodium falciparum and Plasmodium vivax in whole blood with Surface-enhanced Raman Spectroscopy using Nanostructured Gold Substrate.Materials and methodsThe blood samples collected from patients were first lysed and centrifuged before dropping on the gold nano-structure (AuNS) substrate. Malaria diagnosis was performed by detecting Raman peaks from Surface Enhanced Raman Spectroscopy (SERS) with a 532 nm laser excitation.ResultsRaman peaks at 1370 cm−1, 1570 cm−1, and 1627 cm−1, known to have high specificity against interference from other mosquito-borne diseases such as Dengue and West Nile virus infection, were selected as the fingerprint markers associated with P. falciparum and P. vivax infection. The limit of detection was 10−5 dilution, corresponding to the concentration of parasitized blood cells of 100/mL. A total number of 25 clinical samples, including 5 from patients with P. falciparum infection, 10 with P. vivax infection and 10 from healthy volunteers, were evaluated to support its clinical practical use. The whole assay on malaria detection took 30 min to complete.ConclusionsWhile the samples analyzed in this work have strong clinical relevance, we have clearly demonstrated that sensitive malaria detection using AuNS-SERS is a practical direction for rapid in-field diagnosis of malaria infection.
       
  • Impact of miR-SNP rs2910164 on miR-146a expression in osteoarthritic
           chondrocytes
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Ioanna Papathanasiou, Evanthia Mourmoura, Charalampos Balis, Aspasia TsezouAbstractPurposeMiR-146a acts as a negative inflammatory mediator in different diseases and has been implicated in osteoarthritis (OA) pathogenesis. In our study, we investigated the association between miR-SNP rs2910164 and OA susceptibility and its role on the expression of miR-146a, inflammatory and catabolic mediators in osteoarthritic chondrocytes.Materials and methodsGenetic association analysis was performed in 1688 knee OA patients and healthy individuals of Greek origin. Genomic DNA was extracted from blood and genotyped for rs2910164 (G > C) using Restriction-Fragment Length Polymorphism (RFLP). Total RNA was extracted from chondrocytes of 18 OA patients and miR-146a, IL-1 Receptor-Associated Kinase 1 (IRAK-1), TNF Receptor-Associated Factor 6 (TRAF-6), A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 (ADAMTS-5), Matrix Metalloproteinase-13 (MMP-13), Interleukin-6 (IL-6), Interleukin-1 Beta (IL-1β) and Tumor Necrosis Factor-Alpha (TNF-α) expression was evaluated using quantitative Real-Time PCR (qRT-PCR).ResultsOA patients carrying rs2910164-GC and CC genotypes did not have an increased risk for OA development compared to GG genotype carriers. MiR-146a expression in OA chondrocytes was significantly lower in patients with rs2910164-GC genotype than in the GG carriers. OA patients carrying the rs2910164-GC genotype in their chondrocytes exhibited increased IRAK-1, TRAF-6, MMP-13, IL-1β and IL-6 expression levels compared with rs2910164-GG carriers.ConclusionWe demonstrate, for the first time, that miR-SNP rs2910164 in miR-146a gene is associated with reduced miR-146a and increased inflammatory and catabolic mediators’ expression in OA chondrocytes. Our data imply that genetic variations in miRNAs linked to OA pathogenesis may regulate their expression levels, suggesting new therapeutic strategies for patients with cartilage diseases.
       
  • CRB1rd8 mutation influences the age-related macular degeneration phenotype
           of NRF2 knockout mice and favors choroidal neovascularization
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Elisabeth Richert, Alexa Klettner, Claus von der Burchard, Johann Roider, Jan TodeAbstractPurposeWe examined the influence of retinal degeneration 8 (rd8) mutation of crumbs homolog 1 (CRB1) gene on age-related macular degeneration (AMD) phenotype in nuclear factor E2-related factor 2 knock out (NRF2−/−) mouse model.MethodsCRB1rd8 mutation genotype was determined by polymerase chain reaction from tail clips in 73 NRF2−/− mice originating from C57BL/6J background on mixed C57BL/6J and C57BL/6N ancestry. The clinical grade of AMD-like fundus alterations was determined by funduscopy, optical coherence tomography (OCT) and fluorescein angiography (FLA) at the age of 9 or 12 months.ResultsTwelve NRF2−/− mice were wildtype CRB1+/+, 61 NRF2−/− were homozygous CRB1rd8/rd8. NRF2−/−CRB1rd8/rd8 mice had a significantly higher probability to show an advanced grade (grade 4 and 5) of AMD-like fundus alterations known to appear in NRF2−/− mice. Choroidal neovascularization (CNV) was only detected in NRF2−/−CRB1rd8/rd8 homozygous mice.ConclusionsHomozygous CRB1rd8/rd8 mutation is common in commercial vendor mice strains of C57BL/6J origin if partly on C57BL/6N ancestry. The mutation has an influence on the extent of AMD-like retinal alterations in NRF2−/− mice and favors CNV formation.
       
  • Vitamin D deficiency and thyroid autoantibody fluctuations in patients
           
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Maria Teresa Płazińska, Agata Czarnywojtek, Nadia Sawicka-Gutaj, Małgorzata Zgorzalewicz-Stachowiak, Barbara Czarnocka, Paweł Gut, Maria Karlinska, Marta Fichna, Adam Stachowski, Marek Ruchała, Iwona Krela-Kaźmierczak, Leszek KrólickiAbstractPurposeThe aim of this study was to evaluate the association between vitamin D (vitD) and changes in the titers of anti-TSH receptor (TSHR-Abs), antithyroglobulin (Tg-Abs), and antiperoxidase (TPO-Abs) autoantibodies.Materials/methodsThe study involved 269 patients with Graves’ disease (GD), divided into four subgroups (1–4), i.e. 65 smokers treated with vitD(+) (1), 76 smokers not treated with vitD(−) (2), 61 non-smokers treated with vitD(+) (3) and 67 non-smokers with vitD(−) (4). All thyroid parameters were analyzed at entry and 1, 3, 6, 9 and 12 months later.ResultsThe titer of TSHR-Abs in group 3 was significantly lower than in groups 1 and 2 across all time points. At 3, 6 and 12 months, the titers of TSHR-Abs were also lower in group 4 compared to groups 1 and 2. At 9 months, the titers in group 3 were lower than in all other groups. There was a significant inverse correlation between baseline levels of vitD and baseline titers of Tg-Abs (in group 1 only), Tg-Abs after 12 months (in group 1 only), TPO-Abs after 12 months (in groups 1 and 3), fT4 (in group 4 only), and a significant positive correlation with TPO-Abs (in group 2 only). VitD levels at 12 months were inversely correlated with Tg-Abs in group 1.ConclusionsVitD measurements in patients with GD, especially smokers with an increased TSHR-Ab titers before 131I therapy, are recommended. Immunological remission is more likely in patients with GD who receive vitD, particularly smokers.
       
  • Normal tolerance limits for side-to-side differences in diameters of major
           lower limbs arteries of 228 healthy subjects
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Krzysztof Jan Kubarewicz, Andrzej Ustymowicz, Dorota Czyzewska, Marcin Jakub Kaminski, Rafal Sledziewski, Jaroslaw KrejzaAbstractPurposeTo determine reference values and tolerance limits of between-side differences for the calibers of the common femoral artery (CFA), superficial femoral artery (SFA), popliteal artery (PA), dorsalis pedis artery (DPA), and posterior tibial artery (PTA).Materials and methodsCalibers of arteries, defined as the largest distance between internal hyperechogenic lines of the intima-media complex of the arterial wall, were measured during the diastole phase determined from echo-tracking B mode ultrasound scanning and grey-scale ultrasound in 228 healthy volunteers aged 18–81 years (43.1 ± 16.7).ResultsThe mean, 95% confidence and tolerance limits covering 90% of population for left and right side of each artery were: CFA: 8.1 mm, 7.9–8.3 mm, 6.0–10.3 mm; 8.1 mm, 7.9–8.5 mm, 5.9–10.2 mm; SFA: 6.2 mm, 6.0–6.3 mm, 4.7–7.6 mm; 6.1 mm, 6.0–6.3 mm, 4.7–7.6 mm; PA: 6.1 mm, 6.0–6.2 mm, 4.6–7.6 mm; 6.1 mm, 5.9–6.2 mm, 4.5–7.6 mm; DPA: 2.0 mm, 1.9–2.0 mm, 1.2–2.7 mm; 2.0 mm, 1.9–2.0 mm, 1.2–2.8 mm; PTA: 2.1 mm, 2.0–2.1 mm, 1.4–2.8 mm; 2.1 mm, 2.1–2.2 mm, 1.4–2.8 mm, respectively. Tolerance limits for between-side differences and ratios were: CFA - 0.5–0.7 mm, 0.9–1.1; SFA - 0.5–0.6 mm, 0.9–1.1; PA - 0.5–0.5 mm, 0.9–1.1; DPA -0.4-0.4 mm, 0.8–1.2; PTA - 0.4–0.4 mm, 0.8–1.2. Regression analysis showed weight and age dependency of vessels diameters. There are no differences between men and woman in vessels size, except in DPA's, when body weight and age are taken into account in a regression analysis.ConclusionsWe estimated normal reference tolerance limits of side-to-side differences in diameters of lower limb arteries. The limits can inform an investigator what differences in diameters occur in healthy individuals, and hence can serve as cut-offs in diagnostic and screening strategies.
       
  • Unveiling the genetic etiology of primary ciliary dyskinesia: When
           standard genetic approach is not enough
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Rute Pereira, Telma Barbosa, Ângela Alves, Rosário Santos, Jorge Oliveira, Mário SousaAbstractPurposePrimary ciliary dyskinesia (PCD) is a ciliopathy caused by dysfunction of motile cilia. As there is still no standard PCD diagnostics, the final diagnosis requires a combination of several tests. The genetic screening is a hallmark for the final diagnosis and requires high-throughput techniques, such as whole-exome sequencing (WES). Nevertheless, WES has limitations that may prevent a definitive genetic diagnosis. Here we present a case that demonstrates how the PCD genetic diagnosis may not be trivial.Materials/methodsA child with PCD and situs inversus totalis (designated as Kartagener syndrome (KS)) was subjected to clinical assessments, ultrastructural analysis of motile cilia, extensive genetic evaluation by WES and chromosomal array analysis, bioinformatic analysis, gene expression analysis and immunofluorescence to identify the genetic etiology. His parents and sister, as well as healthy controls were also evaluated.ResultsHere we show that a disease-causing variant in the USP11 gene and copy number variations in CRHR1 and KRT34 genes may be involved in the patient PCD phenotype. None of these genes were previously reported in PCD patients and here we firstly show its presence and immunolocalization in respiratory cells.ConclusionsThis work highlights how the genetic diagnosis can turn to be rather complex and that combining several approaches may be needed. Overall, our results contribute to increase the understanding of the genetic factors involved in the pathophysiology of PCD/KS, which is of paramount importance to assist the current diagnosis and future development of newer therapies.
       
  • Metabolomic profiling in children with inflammatory bowel disease
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Aleksandra Filimoniuk, Urszula Daniluk, Paulina Samczuk, Natalia Wasilewska, Piotr Jakimiec, Magdalena Kucharska, Dariusz M. Lebensztejn, Michał CiborowskiAbstractUlcerative colitis (UC) and Crohn's disease (CD) represent inflammatory bowel diseases (IBD) with multifactorial pathogenesis, involving genetic, environmental and microbial factors. Interactions between gut microbiota and immune system result in changes in metabolic pathways. Metabolomics is a comprehensive and quantitative (or semi-quantitative) analysis of metabolites synthetized in human's biological system. It has been shown that metabolic profiling might be used to identify disease biomarkers. Recent findings confirmed alterations in the number of metabolites in patients with IBD. However, most of the studies included adult individuals with ongoing treatment which might have affected the metabolite profiling. Therefore, the aim of our study was to collect the knowledge about metabolomics in paediatric patients with CD or UC based on the currently published literature.
       
  • Life with the pancreas: A personal experience
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Jean MorissetAbstractThis review article has primary objective to summarize pancreatic research which has been done in our laboratory since 1965, the first year of the author's registration in the Ph.D. program at the University of Sherbrooke (Canada). It covers the following major topics of pancreatic physiology: controls of pancreatic adaptation to diet, control of pancreatic enzyme secretion, control of pancreatic enzyme synthesis, control of pancreatic growth, intracellular events stimulated during pancreatic growth, pancreas regeneration after pancreatitis and pancreatectomy, the pancreatic cholecystokinin receptor types 1 and 2, growth control and cell signaling in pancreatic cancer cells and finally, cystic fibrosis.
       
  • The clinical applications of a multigene liquid biopsy (NETest) in
           neuroendocrine tumors
    • Abstract: Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Anna Malczewska, Beata Kos-Kudła, Mark Kidd, Ignat Drozdov, Lisa Bodei, Somer Matar, Kjell Oberg, Irvin M. ModlinAbstractPurposeThere are few effective biomarkers for neuroendocrine tumors. Precision oncology strategies have provided liquid biopsies for real-time and tailored decision-making. This has led to the development of the first neuroendocrine tumor liquid biopsy (the NETest). The NETest represents a transcriptomic signature of neuroendocrine tumor (NETs) that captures tumor biology and disease activity. The data have direct clinical application in terms of identifying residual disease, disease progress and the efficacy of treatment. In this overview we assess the available published information on the metrics and clinical efficacy of the NETest.Material and methodsPublished data on the NETest have been collated and analyzed to understand the clinical application of this multianalyte biomarker in NETs.ResultsNETest assay has been validated as a standardized and reproducible clinical laboratory measurement. It is not affected by demographic characteristics, or acid suppressive medication. Clinical utility of the NETest has been documented in gastroenteropancreatic, bronchopulmonary NETs, in paragangliomas and pheochromocytomas. The test facilitates accurate diagnosis of a NET disease, and real-time monitoring of the disease status (stable/progressive disease). It predicts aggressive tumor behavior, identifies operative tumor resection, and efficacy of the medical treatment (e.g. somatostatin analogues), or peptide receptor radionuclide therapy (PRRT). NETest metrics and clinical applications out-perform standard biomarkers like chromogranin A.ConclusionsThe NETest exhibits clinically competent metrics as an effective biomarker for neuroendocrine tumors. Measurement of NET transcripts in blood is a significant advance in neuroendocrine tumor management and demonstrates that blood provides a viable source to identify and monitor tumor status.
       
 
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