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  Subjects -> MEDICAL SCIENCES (Total: 7655 journals)
    - ALLERGOLOGY AND IMMUNOLOGY (196 journals)
    - ANAESTHESIOLOGY (110 journals)
    - CARDIOVASCULAR DISEASES (316 journals)
    - CHIROPRACTIC, HOMEOPATHY, OSTEOPATHY (21 journals)
    - COMMUNICABLE DISEASES, EPIDEMIOLOGY (207 journals)
    - DENTISTRY (258 journals)
    - DERMATOLOGY AND VENEREOLOGY (155 journals)
    - EMERGENCY AND INTENSIVE CRITICAL CARE (112 journals)
    - ENDOCRINOLOGY (143 journals)
    - FORENSIC SCIENCES (38 journals)
    - GASTROENTEROLOGY AND HEPATOLOGY (168 journals)
    - GERONTOLOGY AND GERIATRICS (123 journals)
    - HEMATOLOGY (140 journals)
    - HYPNOSIS (4 journals)
    - INTERNAL MEDICINE (144 journals)
    - LABORATORY AND EXPERIMENTAL MEDICINE (95 journals)
    - MEDICAL GENETICS (59 journals)
    - MEDICAL SCIENCES (1946 journals)
    - NURSES AND NURSING (313 journals)
    - OBSTETRICS AND GYNECOLOGY (189 journals)
    - ONCOLOGY (363 journals)
    - OPHTHALMOLOGY AND OPTOMETRY (126 journals)
    - ORTHOPEDICS AND TRAUMATOLOGY (149 journals)
    - OTORHINOLARYNGOLOGY (80 journals)
    - PATHOLOGY (99 journals)
    - PEDIATRICS (250 journals)
    - PHYSICAL MEDICINE AND REHABILITATION (151 journals)
    - PSYCHIATRY AND NEUROLOGY (772 journals)
    - RADIOLOGY AND NUCLEAR MEDICINE (186 journals)
    - RESPIRATORY DISEASES (96 journals)
    - RHEUMATOLOGY (65 journals)
    - SPORTS MEDICINE (73 journals)
    - SURGERY (370 journals)
    - UROLOGY, NEPHROLOGY AND ANDROLOGY (138 journals)

MEDICAL SCIENCES (1946 journals)                  1 2 3 4 5 6 7 8 | Last

Showing 1 - 200 of 3562 Journals sorted alphabetically
16 de Abril     Open Access  
3D Printing in Medicine     Open Access  
AADE in Practice     Hybrid Journal   (Followers: 5)
ABCS Health Sciences     Open Access   (Followers: 3)
Abia State University Medical Students' Association Journal     Full-text available via subscription  
ACIMED     Open Access   (Followers: 1)
ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 41)
Acta Bio Medica     Full-text available via subscription   (Followers: 2)
Acta Bioethica     Open Access  
Acta Bioquimica Clinica Latinoamericana     Open Access   (Followers: 1)
Acta Facultatis Medicae Naissensis     Open Access  
Acta Informatica Medica     Open Access   (Followers: 1)
Acta Medica (Hradec Králové)     Open Access  
Acta Medica Bulgarica     Open Access  
Acta Medica Colombiana     Open Access   (Followers: 1)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Medica Indonesiana     Open Access  
Acta Medica International     Open Access  
Acta medica Lituanica     Open Access  
Acta Medica Marisiensis     Open Access  
Acta Medica Martiniana     Open Access  
Acta Medica Nagasakiensia     Open Access  
Acta Medica Peruana     Open Access   (Followers: 2)
Acta Médica Portuguesa     Open Access  
Acta Medica Saliniana     Open Access  
Acta Scientiarum. Health Sciences     Open Access   (Followers: 1)
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 4)
Acupuncture and Natural Medicine     Open Access  
Addiction Science & Clinical Practice     Open Access   (Followers: 6)
Addictive Behaviors Reports     Open Access   (Followers: 8)
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / Health Sciences Journal of Adıyaman University     Open Access  
Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi     Open Access  
Advanced Biomedical Research     Open Access  
Advanced Health Care Technologies     Open Access   (Followers: 4)
Advanced Science, Engineering and Medicine     Partially Free   (Followers: 7)
Advances in Bioscience and Clinical Medicine     Open Access   (Followers: 5)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28)
Advances in Life Course Research     Hybrid Journal   (Followers: 8)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Medical Education and Practice     Open Access   (Followers: 25)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Medicine     Open Access   (Followers: 2)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4)
Advances in Molecular Oncology     Open Access   (Followers: 2)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7)
Advances in Parkinson's Disease     Open Access  
Advances in Phytomedicine     Full-text available via subscription  
Advances in Preventive Medicine     Open Access   (Followers: 5)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 19)
Advances in Skeletal Muscle Function Assessment     Open Access  
Advances in Therapy     Hybrid Journal   (Followers: 5)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5)
Advances in Wound Care     Hybrid Journal   (Followers: 10)
African Health Sciences     Open Access   (Followers: 2)
African Journal of Biomedical Research     Open Access  
African Journal of Clinical and Experimental Microbiology     Open Access   (Followers: 1)
African Journal of Laboratory Medicine     Open Access   (Followers: 2)
African Journal of Medical and Health Sciences     Open Access   (Followers: 2)
African Journal of Trauma     Open Access   (Followers: 1)
Afrimedic Journal     Open Access   (Followers: 2)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 8)
AJOB Primary Research     Partially Free   (Followers: 3)
AJSP: Reviews & Reports     Hybrid Journal  
Aktuelle Ernährungsmedizin     Hybrid Journal   (Followers: 4)
Al-Azhar Assiut Medical Journal     Open Access  
Alexandria Journal of Medicine     Open Access   (Followers: 1)
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 2)
Alpha Omegan     Full-text available via subscription  
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 3)
American Journal of Biomedical Engineering     Open Access   (Followers: 12)
American Journal of Biomedical Research     Open Access   (Followers: 2)
American Journal of Biomedicine     Full-text available via subscription   (Followers: 7)
American Journal of Chinese Medicine, The     Hybrid Journal   (Followers: 4)
American Journal of Clinical Medicine Research     Open Access   (Followers: 6)
American Journal of Family Therapy     Hybrid Journal   (Followers: 11)
American Journal of Law & Medicine     Full-text available via subscription   (Followers: 11)
American Journal of Lifestyle Medicine     Hybrid Journal   (Followers: 5)
American Journal of Managed Care     Full-text available via subscription   (Followers: 11)
American Journal of Medical Case Reports     Open Access   (Followers: 1)
American Journal of Medical Sciences and Medicine     Open Access   (Followers: 3)
American Journal of Medicine     Hybrid Journal   (Followers: 43)
American Journal of Medicine and Medical Sciences     Open Access   (Followers: 1)
American Journal of Medicine Studies     Open Access  
American Journal of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American Journal of the Medical Sciences     Hybrid Journal   (Followers: 12)
American Journal on Addictions     Hybrid Journal   (Followers: 7)
American medical news     Free   (Followers: 3)
American Medical Writers Association Journal     Full-text available via subscription   (Followers: 5)
Amyloid: The Journal of Protein Folding Disorders     Hybrid Journal   (Followers: 5)
Anales de la Facultad de Medicina     Open Access  
Anales de la Facultad de Medicina, Universidad de la República, Uruguay     Open Access  
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1)
Analgesia & Resuscitation : Current Research     Hybrid Journal   (Followers: 5)
Anatolian Clinic the Journal of Medical Sciences     Open Access  
Anatomical Science International     Hybrid Journal   (Followers: 2)
Anatomical Sciences Education     Hybrid Journal   (Followers: 1)
Anatomy     Open Access  
Anatomy Research International     Open Access   (Followers: 2)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3)
Ankara Medical Journal     Open Access   (Followers: 2)
Ankara Üniversitesi Tıp Fakültesi Mecmuası     Open Access  
Annales de Pathologie     Full-text available via subscription  
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 3)
Annals of African Medicine     Open Access   (Followers: 1)
Annals of Anatomy - Anatomischer Anzeiger     Hybrid Journal   (Followers: 2)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18)
Annals of Biomedical Sciences     Full-text available via subscription   (Followers: 3)
Annals of Clinical Microbiology and Antimicrobials     Open Access   (Followers: 10)
Annals of Family Medicine     Open Access   (Followers: 12)
Annals of Fundeni Hospital     Open Access   (Followers: 1)
Annals of Ibadan Postgraduate Medicine     Open Access  
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Medicine     Hybrid Journal   (Followers: 12)
Annals of Medicine and Surgery     Open Access   (Followers: 7)
Annals of Microbiology     Hybrid Journal   (Followers: 10)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Saudi Medicine     Open Access  
Annals of the New York Academy of Sciences     Hybrid Journal   (Followers: 5)
Annals of The Royal College of Surgeons of England     Full-text available via subscription   (Followers: 3)
Annual Reports in Medicinal Chemistry     Full-text available via subscription   (Followers: 7)
Annual Reports on NMR Spectroscopy     Full-text available via subscription   (Followers: 4)
Annual Review of Medicine     Full-text available via subscription   (Followers: 17)
Anthropological Review     Open Access   (Followers: 23)
Anthropologie et santé     Open Access   (Followers: 5)
Antibiotics     Open Access   (Followers: 9)
Antibodies     Open Access   (Followers: 2)
Antibody Technology Journal     Open Access   (Followers: 1)
Anuradhapura Medical Journal     Open Access  
Anwer Khan Modern Medical College Journal     Open Access   (Followers: 2)
Apmis     Hybrid Journal   (Followers: 1)
Apparence(s)     Open Access   (Followers: 1)
Applied Clinical Research, Clinical Trials and Regulatory Affairs     Hybrid Journal  
Applied Medical Informatics     Open Access   (Followers: 10)
Arab Journal of Nephrology and Transplantation     Open Access   (Followers: 1)
Arak Medical University Journal     Open Access  
Archive of Clinical Medicine     Open Access   (Followers: 1)
Archive of Community Health     Open Access   (Followers: 1)
Archives Medical Review Journal / Arşiv Kaynak Tarama Dergisi     Open Access  
Archives of Medical and Biomedical Research     Open Access   (Followers: 3)
Archives of Medical Laboratory Sciences     Open Access   (Followers: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Medicine and Surgery     Open Access  
Archives of Trauma Research     Open Access   (Followers: 3)
Archivos de Medicina (Manizales)     Open Access  
ArgoSpine News & Journal     Hybrid Journal  
Arquivos Brasileiros de Oftalmologia     Open Access  
Arquivos de Ciências da Saúde     Open Access  
Arquivos de Medicina     Open Access  
Ars Medica : Revista de Ciencias Médicas     Open Access  
ARS Medica Tomitana     Open Access   (Followers: 1)
Art Therapy: Journal of the American Art Therapy Association     Full-text available via subscription   (Followers: 12)
Arterial Hypertension     Open Access   (Followers: 1)
Artificial Intelligence in Medicine     Hybrid Journal   (Followers: 12)
Artificial Organs     Hybrid Journal   (Followers: 1)
ASHA Leader     Open Access  
Asia Pacific Family Medicine     Open Access   (Followers: 1)
Asia Pacific Journal of Clinical Nutrition     Full-text available via subscription   (Followers: 10)
Asia Pacific Journal of Clinical Trials : Nervous System Diseases     Open Access  
Asian Bioethics Review     Full-text available via subscription   (Followers: 3)
Asian Journal of Cell Biology     Open Access   (Followers: 5)
Asian Journal of Health     Open Access   (Followers: 3)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 3)
Asian Journal of Medical and Pharmaceutical Researches     Open Access   (Followers: 1)
Asian Journal of Medical Sciences     Open Access   (Followers: 2)
Asian Journal of Scientific Research     Open Access   (Followers: 3)
Asian Journal of Transfusion Science     Open Access   (Followers: 1)
Asian Medicine     Hybrid Journal   (Followers: 5)
Asian Pacific Journal of Cancer Prevention     Open Access  
ASPIRATOR : Journal of Vector-borne Disease Studies     Open Access  
Astrocyte     Open Access  
Atención Familiar     Open Access  
Atención Primaria     Open Access   (Followers: 1)
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche     Open Access  
Audiology - Communication Research     Open Access   (Followers: 9)
Auris Nasus Larynx     Full-text available via subscription  
Australian Coeliac     Full-text available via subscription   (Followers: 1)
Australian Family Physician     Full-text available via subscription   (Followers: 3)
Australian Journal of Medical Science     Full-text available via subscription   (Followers: 1)
Autopsy and Case Reports     Open Access  
Aviation, Space, and Environmental Medicine     Full-text available via subscription   (Followers: 10)
Avicenna     Open Access   (Followers: 3)
Avicenna Journal of Clinical Medicine     Open Access  
Avicenna Journal of Medicine     Open Access   (Followers: 1)
Bangabandhu Sheikh Mujib Medical University Journal     Open Access   (Followers: 1)
Bangladesh Journal of Anatomy     Open Access   (Followers: 1)
Bangladesh Journal of Bioethics     Open Access  
Bangladesh Journal of Medical Biochemistry     Open Access   (Followers: 3)
Bangladesh Journal of Medical Education     Open Access   (Followers: 2)
Bangladesh Journal of Medical Microbiology     Open Access   (Followers: 3)
Bangladesh Journal of Medical Physics     Open Access  
Bangladesh Journal of Medical Science     Open Access  
Bangladesh Journal of Medicine     Open Access   (Followers: 1)
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Bangladesh Journal of Scientific Research     Open Access   (Followers: 1)
Bangladesh Medical Journal     Open Access  

        1 2 3 4 5 6 7 8 | Last

Journal Cover
American Journal of Medicine
Number of Followers: 43  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0002-9343 - ISSN (Online) 1555-7162
Published by Elsevier Homepage  [3163 journals]
  • Altruism: A Story in Three Acts,,✰✰✰
    • Abstract: Publication date: Available online 23 June 2018
      Source:The American Journal of Medicine
      Author(s): Dominick Tammaro, James Arrighi, Ross Hilliard, Elizabeth Toll


      PubDate: 2018-06-24T00:46:45Z
       
  • The Reply
    • Abstract: Publication date: Available online 20 June 2018
      Source:The American Journal of Medicine
      Author(s): Joseph S. Alpert


      PubDate: 2018-06-21T00:43:31Z
       
  • Lesson learned through a case of pneumococcal meningitis: sometimes doing
           less is more harmful.
    • Abstract: Publication date: Available online 19 June 2018
      Source:The American Journal of Medicine
      Author(s): Ashish Verma, MuhammadHassaan Shahid, Laura Youngblood


      PubDate: 2018-06-21T00:43:31Z
       
  • The Reply
    • Abstract: Publication date: Available online 19 June 2018
      Source:The American Journal of Medicine
      Author(s): Larry A. Weinrauch, John A. D'Elia, Matthew R. Weir, Suphamai Bunnapradist, Peter V. Finn, Jiankang Liu, Brian Claggett, Anthony P. Monaco


      PubDate: 2018-06-21T00:43:31Z
       
  • Strongyloides Hyperinfection
    • Abstract: Publication date: Available online 19 June 2018
      Source:The American Journal of Medicine
      Author(s): Rhonda Dillon, David J. Riedel


      PubDate: 2018-06-21T00:43:31Z
       
  • Medical Axioms: The Pithy Little Sayings That Reflect Deeper Knowledge
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Joseph S. Alpert


      PubDate: 2018-06-18T00:38:33Z
       
  • Learning to De-Adopt Ineffective Healthcare Practices
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Kevin Selby, Geoffrey D. Barnes


      PubDate: 2018-06-18T00:38:33Z
       
  • Returning to (Electronic) Health Records That Guide and Teach
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Shuai Xu, Arthur Papier


      PubDate: 2018-06-18T00:38:33Z
       
  • Will Cardio-Virology Be the Next Cardio-Oncology'
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Stephen A. Geraci


      PubDate: 2018-06-18T00:38:33Z
       
  • Geographic Variability in Liver Disease-Related Mortality Rates in the
           United States
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Archita P. Desai, Prashanthinie Mohan, Anne M. Roubal, Ricki Bettencourt, Rohit Loomba
      Purpose Liver disease is an important cause of morbidity and mortality in the United States. Geographic variations in the burden of chronic liver disease may have significant impact on public health policies but have not been explored at the national level. The objective of this study is to examine interstate variability in liver disease mortality in the United States. Methods We compared liver disease mortality from the 2010 National Vital Statistics Report on a state level. States in each quartile of liver disease mortality were compared with regard to viral hepatitis death rates, alcohol consumption, obesity, ethnic and racial composition, and household income. Race, ethnicity, and median household income data were derived from the 2010 US Census. Alcohol consumption and obesity data were obtained from the 2010 Behavioral Risk Factor Surveillance System Survey. Results and Conclusion We found significant interstate variability in liver disease mortality, ranging from 6.4 to 17.0 per 100,000. The South and the West carry some of the highest rates of liver disease mortality. In addition to viral hepatitis death rates, there is a strong correlation between higher percentage of Hispanic population and a state's liver disease mortality rate (r = 0.538, P < .001). Lower household income (r = 0.405, P = .003) was also associated with the higher liver disease mortality. While there was a trend between higher obesity rates and higher liver disease mortality, the correlation was not strong and there was no clear association between alcohol consumption and liver disease mortality rates.

      PubDate: 2018-06-18T00:38:33Z
       
  • A Review of Women's Neurology
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Mary Angela O'Neal
      Concern about what is best practice when caring for women with neurologic disease is a common clinical scenario. Therefore, knowledge about women's health issues and their intersection with neurologic disorders is imperative. This review will discuss the appropriate gender-based considerations in epilepsy, multiple sclerosis, migraine, autoimmune disease, sleep disorders, stroke, and paraneoplastic disorders.

      PubDate: 2018-06-18T00:38:33Z
       
  • Management of Common Benign Anorectal Disease: What All Physicians Need to
           Know
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): David Parés, Herand Abcarian
      Benign anorectal conditions produce anal pain, rectal bleeding, or discharge from the perianal region, which are highly prevalent symptoms in the general population. Hemorrhoidal disease, anal fissure, perianal abscess, proctalgia syndromes, and pruritus anii are the most common clinical disorders. Well-trained physicians, irrespective of their specialty, can treat most of these disorders and refer them to a specialist in proctology only when necessary. The aim of this review is to provide a practical guide to the management of benign anorectal disorders in terms of their initial management and the criteria for specialist referral.

      PubDate: 2018-06-18T00:38:33Z
       
  • New Injectable Agents for the Treatment of Type 2 Diabetes Part 1 –
           Injectable Insulins
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Christa M. George, AhYoung Byun, Amanda Howard-Thompson
      The United States Food and Drug Administration has recently approved several new insulin products and new formulations of existing insulin products. These new products may provide advantages over older products, such as a lower risk of nocturnal hypoglycemia and ease of dosing; however, they are costly. The first of 2 articles in a series, this review will describe the potential advantages and disadvantages of these new insulin products.

      PubDate: 2018-06-18T00:38:33Z
       
  • Cannabinoids in Patients with Nausea and Vomiting Associated with
           Malignancy and Its Treatments
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Jose M. Garcia, Tatyana A. Shamliyan


      PubDate: 2018-06-18T00:38:33Z
       
  • Eliminating In-Hospital Fecal Occult Blood Testing: Our Experience with
           Disinvestment
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Arjun Gupta, Zhouwen Tang, Deepak Agrawal


      PubDate: 2018-06-18T00:38:33Z
       
  • A Congenital Culprit: Anomalous Origin of the Left Coronary Artery from
           the Pulmonary Artery
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Pooja Prasad, Benjamin R. Stripe, Ezra A. Amsterdam, Gagan D. Singh


      PubDate: 2018-06-18T00:38:33Z
       
  • A Binge and a Breach: Cardiac Tamponade Caused by Haemophilus influenzae
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Anthony J. Kanelidis, Drew Oehler, Cassandra L. Oehler, Jonathan Rosenberg, Jonathan D. Paul


      PubDate: 2018-06-18T00:38:33Z
       
  • No Ordinary Back Pain: Malignant Spinal Cord Compression
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Shing Fung Lee, Frank Chi Sing Wong, Stewart Yuk Tung


      PubDate: 2018-06-18T00:38:33Z
       
  • Gradually Transformed: Parry–Romberg Syndrome
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Carlos Felipe Matute, Felipe Jose Matute, Daniel Cardona, Daniel G. Federman


      PubDate: 2018-06-18T00:38:33Z
       
  • Rivaroxaban Versus Warfarin and Risk of Post-Thrombotic Syndrome Among
           Patients with Venous Thromboembolism
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Mette Søgaard, Peter Brønnum Nielsen, Flemming Skjøth, Jette Nordstrøm Kjældgaard, Craig I. Coleman, Torben Bjerregaard Larsen
      Background The effectiveness of rivaroxaban to reduce post-thrombotic syndrome in patients with venous thromboembolism is largely unknown. We compared rates of post-thrombotic syndrome in patients given rivaroxaban versus warfarin in a cohort of patients with incident venous thromboembolism receiving routine clinical care. Methods We linked Danish nationwide registries to identify all patients with incident venous thromboembolism who were new users of rivaroxaban or warfarin and compared rates of post-thrombotic syndrome using an inverse probability of treatment-weighting approach to account for baseline confounding. Results We identified 19,957 oral anticoagulation–naive patients with incident venous thromboembolism treated with warfarin or rivaroxaban (mean age, 64 years; 48% were female, 45.5% had pulmonary embolism). The propensity-weighted rate of post-thrombotic syndrome at 3 years follow-up was 0.53 incidents per 100 person-years with rivaroxaban versus 0.55 per 100 person-years with warfarin, yielding a hazard rate of 0.88 (95% confidence interval, 0.66-1.17). This association remained consistent across types of venous thromboembolism (deep venous thrombosis vs pulmonary embolism, and provoked vs unprovoked venous thromboembolism) and when censoring patients with recurrent venous thromboembolism. Conclusions In this clinical practice setting, rivaroxaban was associated with lower but statistically nonsignificant rates of post-thrombotic syndrome, which did not appear to be mediated only by an effect on recurrent venous thromboembolism.

      PubDate: 2018-06-18T00:38:33Z
       
  • Thiazolidinediones and Risk of Atrial Fibrillation Among Patients with
           Diabetes and Coronary Disease
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Jannik Langtved Pallisgaard, Maria Mori Brooks, Bernard R. Chaitman, Derek B. Boothroyd, Marco Perez, Mark A. Hlatky
      Background We sought to determine whether insulin-sensitizing therapy (thiazolidinediones or metformin) decreased the risk of developing atrial fibrillation compared with insulin-providing therapy (insulin, sulfonylurea, or a meglitinide). Thiazolidinediones are insulin sensitizers that also decrease the inflammatory response. Because inflammation is a risk factor for atrial fibrillation, we hypothesized that treating diabetes with thiazolidinediones might decrease the risk of developing atrial fibrillation. Methods The Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial enrolled patients with type 2 diabetes and documented coronary artery disease. All patients were randomized to insulin-sensitizing therapy or insulin-providing therapy. Results A total of 2319 patients entered the study, with 1160 assigned to the insulin-sensitization strategy and 1159 assigned to the insulin-provision strategy. Over a median follow-up of 4.2 years, 90 patients (3.9%) developed new-onset atrial fibrillation. In the intention-to-treat analysis, the incidence of atrial fibrillation was 8.7 per 1000 person-years in patients assigned to insulin sensitization compared with 9.5 in patients assigned to insulin provision with a hazard ratio (HR) of 0.91 (95% confidence interval [CI], 0.60-1.38, P = .66). In a time-varying exposure analysis, the incidence rate per 1000 person-years was 7.2 while exposed to thiazolidinediones and 9.7 while not exposed to thiazolidinediones with an adjusted HR of 0.80 (95% CI, 0.33-1.94, P = .62). In a subset of patients matched on propensity to receive a thiazolidinediones, the HR was 0.75 (95% CI, 0.43-1.30, P = .30). Conclusions We did not find a significant reduction of atrial fibrillation incidence with use of thiazolidinediones.

      PubDate: 2018-06-18T00:38:33Z
       
  • Alogliptin in Patients with Type 2 Diabetes Receiving Metformin and
           Sulfonylurea Therapies in the EXAMINE Trial
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): William B. White, Simon R. Heller, Christopher P. Cannon, Heena Howitt, Kamlesh Khunti, Richard M. Bergenstal
      Background We evaluated the antihyperglycemic efficacy and safety of adding the dipeptidyl dipeptidase-4 inhibitor alogliptin to metformin and sulphonylurea in the treatment of type 2 diabetes in the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care Trial. Methods Patients with type 2 diabetes and recent acute coronary syndrome were randomized to alogliptin or placebo and standard of care. Participants were followed for up to 40 (median 18) months. In a subgroup taking metformin and sulphonylurea at baseline, we evaluated change from baseline in glycated hemoglobin (HbA1c), adverse events, cardiovascular outcomes, laboratory data, and other safety parameters. Results There were 1398 patients receiving baseline dual therapy (metformin and sulphonylurea only) randomized to alogliptin (N = 693) or placebo (N = 705); 550 patients receiving alogliptin and 505 patients receiving placebo completed the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care without addition of other antihyperglycemic therapies (P = .008). Changes from baseline to last visit in HbA1c were −0.4% on alogliptin and +0.1% on placebo (P < .001) in all those with baseline dual therapy and −0.4% for alogliptin and +0.2% for placebo (P < .001) in those without additional therapies. Reported rates of hypoglycemia were 8.8% for alogliptin and 6.7% for placebo (P = .16). Cardiovascular death and all-cause mortality rates were lower in those receiving alogliptin compared with those receiving placebo (hazard ratio, 0.49; 95% confidence interval, 0.28-0.84 and hazard ratio, 0.61; 95% confidence interval, 0.38-0.96, respectively). Conclusions Addition of the dipeptidyl peptidase-4 inhibitor alogliptin to dual therapy with metformin plus sulfonylurea significantly reduced HbA1c and was well tolerated. Lower mortality rates were seen in patients treated with alogliptin in this subgroup.

      PubDate: 2018-06-18T00:38:33Z
       
  • Effect of Spironolactone on Myocardial Fibrosis and Other Clinical
           Variables in Patients with Hypertrophic Cardiomyopathy
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Martin S. Maron, Raymond H. Chan, Navin K. Kapur, Iris Z. Jaffe, Adam P. McGraw, Raj Kerur, Barry J. Maron, James E. Udelson
      Background Myocardial fibrosis has proved to be an important marker and determinant in the pathogenesis of hypertrophic cardiomyopathy. In particular, scar formation, if substantial, can promote ventricular tachyarrhythmias or progressive heart failure in the absence of left ventricular outflow obstruction. Therefore, an intervention to mitigate myocardial fibrosis would be potentially advantageous to hypertrophic cardiomyopathy patients. Methods Eligible hypertrophic cardiomyopathy patients were randomized 1:1 in a prospective double-blind fashion to spironolactone 50 mg or placebo to be taken over a 12-month period. The primary endpoint was the effect of mineralocorticoid receptor blockade on serum markers of collagen synthesis and degradation. A number of other functional and morphologic variables and biomarkers comprised secondary exploratory measures. Results Fifty-three hypertrophic cardiomyopathypatients (41 ± 13 years old; 72% men) were randomized; demographic and clinical variable were well matched at baseline. Absolute change between baseline and 12 months did not differ between hypertrophic cardiomyopathy patients treated with spironolactone and those receiving placebo with respect to serum markers of collagen synthesis or degradation, fibrosis by late gadolinium enhancement on cardiac magnetic resonance imaging, or other clinical variables, including objective measure of functional capacity (peak VO2), New York Heart Association functional class, left ventricular wall thickness, mass and volume, and left atrial size, as well as assessment of diastolic function (P = .4-1.0). Conclusions These findings do not support the use of spironolactone in hypertrophic cardiomyopathy to improve left ventricular remodeling by mitigating myocardial fibrosis or altering clinical course.

      PubDate: 2018-06-18T00:38:33Z
       
  • Is the Popularity of Dipeptidyl-Peptidase-4 Inhibitors Justified'
           Insights From Mechanistic Studies and Clinical Trials
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Milton Packer


      PubDate: 2018-06-18T00:38:33Z
       
  • Vena Cava Compression Syndrome in Obesity is Reversed by Bariatric Surgery
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Yvonne Bewarder, Ingrid Kindermann, Michael Böhm


      PubDate: 2018-06-18T00:38:33Z
       
  • From Mechanical to Chemical: A Case of Diabetes Insipidus Induced by
           Concussive Brain Injury
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Muhammad Hassaan Shahid, Ashish Verma, Laura Youngblood


      PubDate: 2018-06-18T00:38:33Z
       
  • Skin and Nasal Involvement: Look for Sarcoidosis!
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Thomas Radulesco, Pierre-André Jarrot, Raphael Cauchois, Nicolas Macagno, Gilles Kaplanski, Patrick Dessi, Justin Michel


      PubDate: 2018-06-18T00:38:33Z
       
  • Sepsis-Associated Encephalopathy with Multiple Microbleeds in Cerebral
           White Matter
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Akihiro Shindo, Kei Suzuki, Yoshiaki Iwashita, Hidekazu Tomimoto


      PubDate: 2018-06-18T00:38:33Z
       
  • Hypertriglyceridemia-Induced Acute Pancreatitis with Normal Pancreatic
           Enzymes
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Sho Kitagawa, Koya Sawai


      PubDate: 2018-06-18T00:38:33Z
       
  • Polymyalgia Rheumatica with Normal Inflammatory Markers
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Shingo Suzuki, Yuta Hirose, Eriko Takeda, Masatomi Ikusaka


      PubDate: 2018-06-18T00:38:33Z
       
  • Importance of Genetic Testing in the Diagnosis of Transthyretin Cardiac
           Amyloidosis
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Jessica R. Golbus, Joanna M. Wells, Michael G. Dickinson, Scott L. Hummel


      PubDate: 2018-06-18T00:38:33Z
       
  • Raccoon Eye Appearance: Amyloidosis
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Hiroki Matsuura, Yoshiaki Anzai, Naoki Kuninaga, Takeshi Maeda


      PubDate: 2018-06-18T00:38:33Z
       
  • How to Attract More Physicians Into Primary Care
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Edward Volpintesta


      PubDate: 2018-06-18T00:38:33Z
       
  • The Reply
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): James E. Dalen


      PubDate: 2018-06-18T00:38:33Z
       
  • Dubious Benefit of Inferior Vena Cava Filters
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Paul A. Bergl


      PubDate: 2018-06-18T00:38:33Z
       
  • The Reply
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Paul D. Stein, Fadi Matta, Mary J. Hughes


      PubDate: 2018-06-18T00:38:33Z
       
  • Comments on Chronic Kidney Disease, Basal Insulin Glargine, and Health
           Outcomes in People with Dysglycemia: The Origin Study
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Saeid Safiri


      PubDate: 2018-06-18T00:38:33Z
       
  • The Reply
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Vasilios Papademetriou


      PubDate: 2018-06-18T00:38:33Z
       
  • Bilateral Tarsal Tunnel Syndrome
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Junpei Komagamine


      PubDate: 2018-06-18T00:38:33Z
       
  • Serum Cardiac Troponin T Levels in Asymptomatic Elderly Nursing Home
           Residents
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Amir Orlev, Robert Klempfner, David Rott
      Background The definition of myocardial infarction relies on elevated troponin levels. However, elevated levels of high sensitive cardiac troponin (hs-cTnT) assays have been reported in elderly patients without acute myocardial infarction. We sought to determine whether elevated hs-cTnT levels have a prognostic value in stable elderly subjects without any acute illness. Methods The study cohort included residents of a nursing home who were asymptomatic without any acute medical problem. Serum hs-cTnT levels were measured, and participants were divided into high and low hs-cTnT groups. We measured hs-cTnT levels of young healthy volunteers as well and compared them with hs-cTnT levels of those nursing home residents. Results Fifty-seven nursing home residents and 14 young volunteers were included in the study. The average age of nursing home residents was 83 ± 14 years, compared with 37 ± 3 years of the volunteers. Levels of hs-cTnT were significantly higher in the elderly compared with the volunteers (0.02 ± 0.016 ng/mL vs 0.005 ± 0.0003 ng/mL; P < .001); accordingly, we chose a cutoff of 0.02 ng/mL hs-cTnT and divided the 57 patients into 2 subgroups for further evaluation. After adjustment for age, gender, and glomerular filtration rate, the hs-cTnT was still an independent predictor of 1-year mortality (relative risk 2.04 [95% conficence interval, 2.009-29.45], P = .003). Conclusions Mild elevations of hs-cTnT levels are common in elderly patients, and hs-cTnT level is an independent marker of mortality risk in this population. For patients older than 70 years, a different hs-cTnT cutoff is required (eg, higher than 0.014 ng/mL).

      PubDate: 2018-06-18T00:38:33Z
       
  • Impact of an Interdisciplinary Computational Research Section in a
           Department of Medicine: An 8-Year Perspective
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Avrum Spira, David Coleman


      PubDate: 2018-06-18T00:38:33Z
       
  • Moments of Wonder
    • Abstract: Publication date: July 2018
      Source:The American Journal of Medicine, Volume 131, Issue 7
      Author(s): Antony Rosen


      PubDate: 2018-06-18T00:38:33Z
       
 
 
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