Publisher: LWW Wolters Kluwer   (Total: 299 journals)

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Showing 1 - 200 of 299 Journals sorted alphabetically
A&A Case Reports     Hybrid Journal   (Followers: 2, SJR: 0.278, CiteScore: 1)
Academic Medicine     Hybrid Journal   (Followers: 74, SJR: 2.53, CiteScore: 2)
ACG Case Reports J.     Open Access  
ACSMs Health & Fitness J.     Full-text available via subscription   (Followers: 15, SJR: 0.207, CiteScore: 0)
Addictive Disorders & Their Treatment     Hybrid Journal   (Followers: 5, SJR: 0.191, CiteScore: 0)
Advanced Emergency Nursing J.     Hybrid Journal   (Followers: 39, SJR: 0.235, CiteScore: 1)
Advances in Anatomic Pathology     Hybrid Journal   (Followers: 21, SJR: 1.012, CiteScore: 3)
Advances in Neonatal Care     Hybrid Journal   (Followers: 47, SJR: 0.438, CiteScore: 1)
Advances in Nursing Science     Hybrid Journal   (Followers: 38, SJR: 0.343, CiteScore: 1)
Advances in Skin & Wound Care     Hybrid Journal   (Followers: 29, SJR: 0.563, CiteScore: 1)
Adverse Drug Reaction Bulletin     Full-text available via subscription   (Followers: 5, SJR: 0.12, CiteScore: 0)
AIDS     Hybrid Journal   (Followers: 23, SJR: 2.919, CiteScore: 4)
AJSP: Reviews & Reports     Hybrid Journal  
Alzheimer Disease & Associated Disorders     Hybrid Journal   (Followers: 19, SJR: 1.157, CiteScore: 2)
American J. of Clinical Oncology     Hybrid Journal   (Followers: 60, SJR: 0.973, CiteScore: 2)
American J. of Dermatopathology     Hybrid Journal   (Followers: 17, SJR: 0.6, CiteScore: 1)
American J. of Forensic Medicine and Pathology     Hybrid Journal   (Followers: 29, SJR: 0.363, CiteScore: 1)
American J. of Gastroenterology, The     Hybrid Journal   (Followers: 175, SJR: 4.197, CiteScore: 5)
American J. of Nursing     Hybrid Journal   (Followers: 80, SJR: 0.284, CiteScore: 0)
American J. of Physical Medicine & Rehabilitation     Hybrid Journal   (Followers: 58, SJR: 0.636, CiteScore: 1)
American J. of Surgical Pathology     Hybrid Journal   (Followers: 38, SJR: 2.531, CiteScore: 6)
American J. of Therapeutics     Hybrid Journal   (Followers: 14, SJR: 0.399, CiteScore: 1)
Anesthesia & Analgesia     Hybrid Journal   (Followers: 254, SJR: 1.472, CiteScore: 3)
Anesthesiology     Hybrid Journal   (Followers: 229, SJR: 2.123, CiteScore: 3)
Annals of Plastic Surgery     Hybrid Journal   (Followers: 22, SJR: 0.893, CiteScore: 1)
Annals of Surgery     Hybrid Journal   (Followers: 77, SJR: 4.361, CiteScore: 5)
Anti-Cancer Drugs     Hybrid Journal   (Followers: 5, SJR: 0.716, CiteScore: 2)
Applied Immunohistochemistry & Molecular Morphology     Hybrid Journal   (Followers: 17, SJR: 0.765, CiteScore: 1)
ASAIO J.     Hybrid Journal   (Followers: 3, SJR: 0.771, CiteScore: 2)
Asia-Pacific J. of Ophthalmology     Full-text available via subscription   (Followers: 3, SJR: 0.64, CiteScore: 1)
Behavioural Pharmacology     Hybrid Journal   (Followers: 2, SJR: 0.916, CiteScore: 2)
Biomedical Safety & Standards     Full-text available via subscription   (Followers: 8)
Blood Coagulation & Fibrinolysis     Hybrid Journal   (Followers: 61, SJR: 0.438, CiteScore: 1)
Blood Pressure Monitoring     Hybrid Journal   (Followers: 1, SJR: 0.537, CiteScore: 1)
Brain & Life     Full-text available via subscription   (Followers: 3)
Canadian J. of Addiction     Hybrid Journal   (Followers: 1)
Cancer J.     Full-text available via subscription   (Followers: 8, SJR: 1.893, CiteScore: 4)
Cancer Nursing     Hybrid Journal   (Followers: 33, SJR: 0.858, CiteScore: 2)
Cardiology in Review     Hybrid Journal   (Followers: 8, SJR: 0.863, CiteScore: 2)
Cardiopulmonary Physical Therapy J.     Hybrid Journal   (Followers: 8)
Cardiovascular Endocrinology & Metabolism     Hybrid Journal   (Followers: 1, SJR: 0.165, CiteScore: 0)
CIN : Computers Informatics Nursing     Hybrid Journal   (Followers: 11, SJR: 0.359, CiteScore: 1)
Clinical and Translational Gastroenterology     Open Access   (SJR: 1.844, CiteScore: 4)
Clinical Dysmorphology     Hybrid Journal   (SJR: 0.268, CiteScore: 0)
Clinical J. of Pain     Hybrid Journal   (Followers: 18, SJR: 1.406, CiteScore: 3)
Clinical J. of Sport Medicine     Hybrid Journal   (Followers: 35, SJR: 0.999, CiteScore: 2)
Clinical Neuropharmacology     Hybrid Journal   (Followers: 3, SJR: 0.506, CiteScore: 1)
Clinical Nuclear Medicine     Hybrid Journal   (Followers: 2, SJR: 0.652, CiteScore: 1)
Clinical Nurse Specialist     Hybrid Journal   (Followers: 28, SJR: 0.256, CiteScore: 0)
Clinical Nutrition Insight     Full-text available via subscription   (Followers: 14)
Clinical Obstetrics & Gynecology     Full-text available via subscription   (Followers: 27, SJR: 0.588, CiteScore: 1)
Clinical Orthopaedics and Related Research     Hybrid Journal   (Followers: 97, SJR: 1.908, CiteScore: 3)
Clinical Pulmonary Medicine     Hybrid Journal   (Followers: 2, SJR: 0.215, CiteScore: 0)
Clinical Spine Surgery     Hybrid Journal   (Followers: 2, SJR: 0.738, CiteScore: 1)
Cognitive and Behavioral Neurology     Hybrid Journal   (Followers: 9, SJR: 0.565, CiteScore: 1)
Colombian J. of Anesthesiology : Revista Colombiana de Anestesiología     Hybrid Journal  
Contemporary Diagnostic Radiology     Full-text available via subscription   (Followers: 3)
Contemporary Neurosurgery     Full-text available via subscription   (Followers: 3)
Contemporary Spine Surgery     Full-text available via subscription   (Followers: 4)
Continuum : Lifelong Learning in Neurology     Hybrid Journal   (Followers: 9, SJR: 0.618, CiteScore: 1)
Cornea     Hybrid Journal   (Followers: 12, SJR: 1.578, CiteScore: 2)
Coronary Artery Disease     Hybrid Journal   (Followers: 2, SJR: 0.705, CiteScore: 1)
Critical Care Explorations     Open Access   (Followers: 1)
Critical Care Medicine     Hybrid Journal   (Followers: 359, SJR: 3.116, CiteScore: 3)
Critical Care Nursing Quarterly     Full-text available via subscription   (Followers: 15, SJR: 0.273, CiteScore: 1)
Critical Pathways in Cardiology     Hybrid Journal   (Followers: 4, SJR: 0.411, CiteScore: 1)
Current Opinion in Allergy and Clinical Immunology     Hybrid Journal   (Followers: 8, SJR: 1.244, CiteScore: 3)
Current Opinion in Anaesthesiology     Hybrid Journal   (Followers: 60, SJR: 0.792, CiteScore: 3)
Current Opinion in Cardiology     Hybrid Journal   (Followers: 14, SJR: 0.97, CiteScore: 2)
Current Opinion in Clinical Nutrition & Metabolic Care     Hybrid Journal   (Followers: 21, SJR: 1.521, CiteScore: 4)
Current Opinion in Critical Care     Hybrid Journal   (Followers: 74, SJR: 1.382, CiteScore: 3)
Current Opinion in Endocrinology, Diabetes and Obesity     Hybrid Journal   (Followers: 51, SJR: 1.467, CiteScore: 3)
Current Opinion in Gastroenterology     Hybrid Journal   (Followers: 15, SJR: 1.515, CiteScore: 3)
Current Opinion in Hematology     Hybrid Journal   (Followers: 18, SJR: 1.588, CiteScore: 3)
Current Opinion in HIV and AIDS     Hybrid Journal   (Followers: 11, SJR: 2.286, CiteScore: 4)
Current Opinion in Infectious Diseases     Hybrid Journal   (Followers: 25, SJR: 1.813, CiteScore: 4)
Current Opinion in Lipidology     Hybrid Journal   (Followers: 6, SJR: 1.847, CiteScore: 3)
Current Opinion in Nephrology & Hypertension     Hybrid Journal   (Followers: 10, SJR: 1.513, CiteScore: 3)
Current Opinion in Neurology     Hybrid Journal   (Followers: 24, SJR: 1.929, CiteScore: 4)
Current Opinion in Obstetrics & Gynecology     Hybrid Journal   (Followers: 13, SJR: 0.992, CiteScore: 3)
Current Opinion in Oncology     Hybrid Journal   (Followers: 24, SJR: 1.217, CiteScore: 3)
Current Opinion in Ophthalmology     Hybrid Journal   (Followers: 31, SJR: 1.434, CiteScore: 3)
Current Opinion in Organ Transplantation     Hybrid Journal   (Followers: 10, SJR: 1.153, CiteScore: 3)
Current Opinion in Otolaryngology & Head & Neck Surgery     Hybrid Journal   (Followers: 12, SJR: 0.683, CiteScore: 2)
Current Opinion in Pediatrics     Hybrid Journal   (Followers: 47, SJR: 1.128, CiteScore: 3)
Current Opinion in Psychiatry     Hybrid Journal   (Followers: 53, SJR: 1.745, CiteScore: 4)
Current Opinion in Pulmonary Medicine     Hybrid Journal   (Followers: 10, SJR: 1.092, CiteScore: 3)
Current Opinion in Rheumatology     Hybrid Journal   (Followers: 18, SJR: 2.187, CiteScore: 4)
Current Opinion in Supportive and Palliative Care     Hybrid Journal   (Followers: 25, SJR: 0.558, CiteScore: 2)
Current Opinion in Urology     Hybrid Journal   (Followers: 11, SJR: 0.949, CiteScore: 2)
Current Orthopaedic Practice     Hybrid Journal   (Followers: 13, SJR: 0.143, CiteScore: 0)
Current Sports Medicine Reports     Full-text available via subscription   (Followers: 22, SJR: 0.448, CiteScore: 1)
Dermatitis     Hybrid Journal   (Followers: 1, SJR: 0.751, CiteScore: 2)
Dermatologic Surgery     Hybrid Journal   (Followers: 8, SJR: 1.168, CiteScore: 1)
Dimensions of Critical Care Nursing     Full-text available via subscription   (Followers: 9, SJR: 0.467, CiteScore: 1)
Diseases of the Colon & Rectum     Hybrid Journal   (Followers: 36, SJR: 1.647, CiteScore: 3)
Ear & Hearing     Hybrid Journal   (Followers: 15, SJR: 1.735, CiteScore: 3)
Egyptian J. of Histology     Partially Free   (SJR: 0.107, CiteScore: 0)
Egyptian J. of Oral and Maxillofacial Surgery     Partially Free   (Followers: 1)
Egyptian J. of Pathology     Partially Free   (Followers: 1)
Emergency Medicine News     Full-text available via subscription   (Followers: 8)
Environmental Epidemiology     Open Access  
Epidemiology     Hybrid Journal   (Followers: 58, SJR: 2.671, CiteScore: 3)
European J. of Anaesthesiology     Hybrid Journal   (Followers: 30, SJR: 1.179, CiteScore: 2)
European J. of Cancer Prevention     Hybrid Journal   (Followers: 3, SJR: 1.021, CiteScore: 2)
European J. of Emergency Medicine     Hybrid Journal   (Followers: 22, SJR: 0.597, CiteScore: 1)
European J. of Gastroenterology & Hepatology     Hybrid Journal   (Followers: 23, SJR: 0.986, CiteScore: 2)
Exercise and Sport Sciences Reviews     Hybrid Journal   (Followers: 54, SJR: 1.943, CiteScore: 4)
Eye & Contact Lens Science and Clinical Practice     Hybrid Journal   (Followers: 4, SJR: 0.949, CiteScore: 2)
Family & Community Health     Hybrid Journal   (Followers: 14, SJR: 0.539, CiteScore: 1)
Female Pelvic Medicine & Reconstructive Surgery     Hybrid Journal   (Followers: 1, SJR: 0.546, CiteScore: 1)
Gastroenterology Nursing     Hybrid Journal   (Followers: 8, SJR: 0.248, CiteScore: 0)
Global Reproductive Health     Open Access  
Harvard Review of Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.375, CiteScore: 3)
Health Care Management Review     Hybrid Journal   (Followers: 15, SJR: 1.244, CiteScore: 2)
Health Physics     Hybrid Journal   (Followers: 7, SJR: 0.528, CiteScore: 1)
Hearing J.     Full-text available via subscription   (Followers: 5, SJR: 0.123, CiteScore: 0)
HemaSphere     Open Access  
Holistic Nursing Practice     Hybrid Journal   (Followers: 6, SJR: 0.239, CiteScore: 1)
Home Healthcare Now     Hybrid Journal   (Followers: 5, SJR: 0.178, CiteScore: 0)
Human Andrology     Partially Free   (Followers: 2)
IJS Global Health     Open Access  
IJS Oncology     Open Access  
Implant Dentistry     Hybrid Journal   (Followers: 7, SJR: 0.712, CiteScore: 1)
Infants and Young Children     Hybrid Journal   (Followers: 7, SJR: 0.412, CiteScore: 1)
Infectious Diseases in Clinical Practice     Hybrid Journal   (Followers: 12, SJR: 0.177, CiteScore: 0)
Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery     Hybrid Journal   (Followers: 1, SJR: 0.432, CiteScore: 1)
Intl. Anesthesiology Clinics     Hybrid Journal   (Followers: 9, SJR: 0.201, CiteScore: 0)
Intl. Clinical Psychopharmacology     Hybrid Journal   (Followers: 2, SJR: 1.086, CiteScore: 3)
Intl. J. of Evidence-Based Healthcare     Hybrid Journal   (Followers: 8, SJR: 0.931, CiteScore: 2)
Intl. J. of Gynecological Pathology     Hybrid Journal   (Followers: 9, SJR: 0.65, CiteScore: 1)
Intl. J. of Rehabilitation Research     Hybrid Journal   (Followers: 20, SJR: 0.583, CiteScore: 2)
Intl. Ophthalmology Clinics     Hybrid Journal   (Followers: 1, SJR: 0.59, CiteScore: 1)
Investigative Radiology     Hybrid Journal   (Followers: 10, SJR: 3.774, CiteScore: 6)
Itch : Intl. Forum for the Study of Itch     Open Access  
J. for Healthcare Quality     Hybrid Journal   (Followers: 24, SJR: 0.633, CiteScore: 1)
J. for Nurses in Professional Development     Hybrid Journal   (Followers: 13, SJR: 0.491, CiteScore: 1)
J. of Acute Care Physical Therapy     Hybrid Journal   (Followers: 1)
J. of Addiction Medicine     Hybrid Journal   (Followers: 7, SJR: 1.063, CiteScore: 2)
J. of Addictions Nursing     Hybrid Journal   (Followers: 7, SJR: 0.229, CiteScore: 0)
J. of Ambulatory Care Management, The     Hybrid Journal   (Followers: 4, SJR: 0.539, CiteScore: 1)
J. of Bronchology & Interventional Pulmonology     Hybrid Journal   (Followers: 5, SJR: 0.455, CiteScore: 1)
J. of Cardiopulmonary Rehabilitation and Prevention     Hybrid Journal   (Followers: 7, SJR: 0.816, CiteScore: 2)
J. of Cardiovascular Medicine     Hybrid Journal   (Followers: 2, SJR: 0.599, CiteScore: 1)
J. of Cardiovascular Nursing     Hybrid Journal   (Followers: 18, SJR: 0.709, CiteScore: 1)
J. of Cardiovascular Pharmacology     Hybrid Journal   (Followers: 7, SJR: 0.917, CiteScore: 2)
J. of Christian Nursing     Hybrid Journal   (Followers: 2, SJR: 0.137, CiteScore: 0)
J. of Clinical Engineering     Full-text available via subscription   (Followers: 1)
J. of Clinical Gastroenterology     Hybrid Journal   (Followers: 11, SJR: 1.245, CiteScore: 2)
J. of Clinical Neuromuscular Disease     Hybrid Journal   (Followers: 1, SJR: 0.358, CiteScore: 1)
J. of Clinical Neurophysiology     Hybrid Journal   (Followers: 3, SJR: 0.629, CiteScore: 2)
J. of Clinical Psychopharmacology     Hybrid Journal   (Followers: 24, SJR: 1.054, CiteScore: 2)
J. of Computer Assisted Tomography     Hybrid Journal   (Followers: 1, SJR: 0.648, CiteScore: 1)
J. of Continuing Education in the Health Professions     Hybrid Journal   (Followers: 12, SJR: 0.606, CiteScore: 1)
J. of Craniofacial Surgery     Hybrid Journal   (Followers: 4, SJR: 0.448, CiteScore: 1)
J. of Developmental & Behavioral Pediatrics     Hybrid Journal   (Followers: 12, SJR: 1.03, CiteScore: 2)
J. of ECT     Hybrid Journal   (Followers: 14, SJR: 0.822, CiteScore: 2)
J. of Forensic Nursing     Hybrid Journal   (Followers: 7, SJR: 0.33, CiteScore: 1)
J. of Geriatric Physical Therapy     Hybrid Journal   (Followers: 11, SJR: 0.691, CiteScore: 2)
J. of Glaucoma     Hybrid Journal   (Followers: 2, SJR: 1.08, CiteScore: 2)
J. of Head Trauma Rehabilitation     Hybrid Journal   (Followers: 16, SJR: 1.545, CiteScore: 3)
J. of Healthcare Management     Hybrid Journal   (Followers: 12, SJR: 0.562, CiteScore: 1)
J. of Hospice & Palliative Nursing     Hybrid Journal   (Followers: 30, SJR: 0.305, CiteScore: 1)
J. of Hypertension     Hybrid Journal   (Followers: 13, SJR: 1.733, CiteScore: 3)
J. of Immunotherapy     Hybrid Journal   (Followers: 7, SJR: 1.373, CiteScore: 4)
J. of Infusion Nursing     Hybrid Journal   (Followers: 4, SJR: 0.251, CiteScore: 1)
J. of Lower Genital Tract Disease     Hybrid Journal   (SJR: 0.602, CiteScore: 1)
J. of Nervous and Mental Disease     Hybrid Journal   (Followers: 6, SJR: 0.988, CiteScore: 2)
J. of Neuro-Ophthalmology     Hybrid Journal   (Followers: 12, SJR: 0.605, CiteScore: 1)
J. of Neurologic Physical Therapy     Hybrid Journal   (Followers: 10, SJR: 1.227, CiteScore: 3)
J. of Neuroscience Nursing     Hybrid Journal   (Followers: 8, SJR: 0.388, CiteScore: 1)
J. of Neurosurgical Anesthesiology     Hybrid Journal   (Followers: 8, SJR: 0.914, CiteScore: 2)
J. of Nursing Administration     Hybrid Journal   (Followers: 32, SJR: 0.727, CiteScore: 1)
J. of Nursing Care Quality     Hybrid Journal   (Followers: 22, SJR: 0.772, CiteScore: 1)
J. of Nursing Research     Open Access   (Followers: 21, SJR: 0.492, CiteScore: 1)
J. of Occupational & Environmental Medicine     Hybrid Journal   (Followers: 22, SJR: 0.812, CiteScore: 1)
J. of Orthopaedic Trauma     Hybrid Journal   (Followers: 19, SJR: 1.451, CiteScore: 2)
J. of Patient Safety     Hybrid Journal   (Followers: 15, SJR: 0.648, CiteScore: 1)
J. of Pediatric Gastroenterology and Nutrition (JPGN)     Hybrid Journal   (Followers: 49, SJR: 1.376, CiteScore: 2)
J. of Pediatric Hematology/Oncology     Hybrid Journal   (Followers: 6, SJR: 0.459, CiteScore: 1)
J. of Pediatric Orthopaedics     Hybrid Journal   (Followers: 14, SJR: 0.913, CiteScore: 2)
J. of Pediatric Orthopaedics B     Hybrid Journal   (Followers: 5, SJR: 0.356, CiteScore: 1)
J. of Pediatric Surgical Nursing     Hybrid Journal   (SJR: 0.123, CiteScore: 0)
J. of Perinatal & Neonatal Nursing     Hybrid Journal   (Followers: 16, SJR: 0.347, CiteScore: 1)
J. of Physical Therapy Education     Hybrid Journal   (Followers: 15)
J. of Prosthetics and Orthotics     Hybrid Journal   (Followers: 13, SJR: 0.214, CiteScore: 0)
J. of Psychiatric Practice     Hybrid Journal   (Followers: 2, SJR: 0.757, CiteScore: 1)
J. of Public Health Management and Practice     Hybrid Journal   (Followers: 5, SJR: 0.797, CiteScore: 1)
J. of Spinal Disorders & Techniques     Hybrid Journal   (Followers: 2, SJR: 1.115, CiteScore: 2)
J. of Strength and Conditioning Research     Hybrid Journal   (Followers: 75, SJR: 1.366, CiteScore: 2)
J. of the American Association of Nurse Practitioners     Hybrid Journal   (Followers: 7)
J. of the Dermatology Nurses' Association     Hybrid Journal   (Followers: 3, SJR: 0.175, CiteScore: 0)
J. of the Egyptian Women’s Dermatologic Society     Partially Free   (SJR: 0.119, CiteScore: 0)
J. of Thoracic Imaging     Hybrid Journal   (Followers: 3, SJR: 0.705, CiteScore: 2)
J. of Trauma and Acute Care Surgery, The     Hybrid Journal   (Followers: 33, SJR: 1.747, CiteScore: 3)
J. of Trauma Nursing     Hybrid Journal   (Followers: 14, SJR: 0.251, CiteScore: 0)
J. of Trauma, The     Full-text available via subscription   (Followers: 22)
J. of Women’s Health Physical Therapy     Partially Free   (Followers: 5)
J. of Wound Ostomy & Continence Nursing     Hybrid Journal   (Followers: 18, SJR: 0.613, CiteScore: 1)
JAAOS : Global Research & Reviews     Open Access   (Followers: 1)

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Similar Journals
Journal Cover
Journal of Cardiovascular Pharmacology
Journal Prestige (SJR): 0.917
Citation Impact (citeScore): 2
Number of Followers: 7  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0160-2446 - ISSN (Online) 1533-4023
Published by LWW Wolters Kluwer Homepage  [299 journals]
  • Cardiovascular Considerations in Treating Patients With Coronavirus
           Disease 2019 (COVID-19)
    • Authors: Dixon; Dave L.; Van Tassell, Benjamin W.; Vecchié, Alessandra; Bonaventura, Aldo; Talasaz, Azita H.; Kakavand, Hessam; D'Ascenzo, Fabrizio; Perciaccante, Antonio; Castagno, Davide; Ammirati, Enrico; Biondi-Zoccai, Giuseppe; Stevens, Michael P.; Abbate, Antonio
      Abstract: image : A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly across the globe since December 2019. Coronavirus disease 2019 (COVID-19) has a significantly higher mortality rate than seasonal influenza and has disproportionately affected older adults, especially those with cardiovascular disease and related risk factors. Adverse cardiovascular sequelae, such as myocarditis, acute myocardial infarction, and heart failure, have been reported in patients with COVID-19. No established treatment is currently available; however, several therapies, including remdesivir, hydroxychloroquine and chloroquine, and interleukin (IL)-6 inhibitors, are being used off-label and evaluated in ongoing clinical trials. Considering these therapies are not familiar to cardiovascular clinicians managing these patients, this review describes the pharmacology of these therapies in the context of their use in patients with cardiovascular-related conditions.
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
  • Deciphering the Dynamics and Therapeutic Potential of the Cardiac cGMP
           Cascade: An Update on Where We Are and What We Need to Know
    • Authors: Lukowski; Robert; Booz, George W.
      Abstract: No abstract available
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
  • Multiplicity of Nitric Oxide and Natriuretic Peptide Signaling in Heart
    • Authors: Preedy; Michael E. J.; Baliga, Reshma S.; Hobbs, Adrian J.
      Abstract: image : Heart failure (HF) is a common consequence of several cardiovascular diseases and is understood as a vicious cycle of cardiac and hemodynamic decline. The current inventory of treatments either alleviates the pathophysiological features (eg, cardiac dysfunction, neurohumoral activation, and ventricular remodeling) and/or targets any underlying pathologies (eg, hypertension and myocardial infarction). Yet, since these do not provide a cure, the morbidity and mortality associated with HF remains high. Therefore, the disease constitutes an unmet medical need, and novel therapies are desperately needed. Cyclic guanosine-3′,5′-monophosphate (cGMP), synthesized by nitric oxide (NO)- and natriuretic peptide (NP)-responsive guanylyl cyclase (GC) enzymes, exerts numerous protective effects on cardiac contractility, hypertrophy, fibrosis, and apoptosis. Impaired cGMP signaling, which can occur after GC deactivation and the upregulation of cyclic nucleotide-hydrolyzing phosphodiesterases (PDEs), promotes cardiac dysfunction. In this study, we review the role that NO/cGMP and NP/cGMP signaling plays in HF. After considering disease etiology, the physiological effects of cGMP in the heart are discussed. We then assess the evidence from preclinical models and patients that compromised cGMP signaling contributes to the HF phenotype. Finally, the potential of pharmacologically harnessing cardioprotective cGMP to rectify the present paucity of effective HF treatments is examined.
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
  • cGMP Signaling and Modulation in Heart Failure
    • Authors: Blanton; Robert M.
      Abstract: image : Cyclic GMP (cGMP) represents a classic intracellular second messenger molecule. Over the past 2 decades, important discoveries have identified that cGMP signaling becomes deranged in heart failure (HF) and that cGMP and its main kinase effector, protein kinase G, generally oppose the biological abnormalities contributing to HF, in experimental studies. These findings have influenced the design of clinical trials of cGMP-augmenting drugs in HF patients. At present, the trial results of cGMP-augmenting therapies in HF remain mixed. As detailed in this review, strong evidence now exists that protein kinase G opposes pathologic cardiac remodeling through regulation of diverse biological processes and myocardial substrates. Potential reasons for the failures of cGMP-augmenting drugs in HF may be related to biological mechanisms opposing cGMP or because of certain features of clinical trials, all of which are discussed.
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
  • Cardiac cGMP Signaling in Health and Disease: Location, Location, Location
    • Authors: Cuello; Friederike; Nikolaev, Viacheslav O.
      Abstract: image : 3′,5′-Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger, which critically regulates cardiac pump function and protects from the development of cardiac hypertrophy by acting in various subcellular microdomains. Although clinical studies testing the potential of cGMP elevating drugs in patients suffering from cardiac disease showed promising results, deeper insight into the local actions of these drugs at the subcellular level are indispensable to inspire novel therapeutic strategies. Detailed information on the spatio-temporal dynamics of cGMP production and degradation can be provided by the use of fluorescent biosensors that are capable of monitoring this second messenger at different locations inside the cell with high temporal and spatial resolution. In this review, we will summarize how these emerging new tools have improved our understanding of cardiac cGMP signaling in health and disease, and attempt to anticipate future challenges in the field.
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
  • PCSK9 Inhibitors in Secondary Prevention—An Opportunity for
           Personalized Therapy
    • Authors: Board; Chase; Kelly, Michael S.; Shapiro, Michael D.; Dixon, Dave L.
      Abstract: image : Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide. Low-density lipoprotein cholesterol (LDL-C) is the primary cause of ASCVD and reducing LDL-C levels with statin therapy significantly reduces ASCVD risk; however, significant residual risk remains. Two monoclonal antibodies (mAbs), alirocumab and evolocumab, that target proprotein convertase subtilisin/kexin-type 9 (PCSK9), reduce LDL-C levels by up to 60% when used in combination with statins and significantly reduce the risk of recurrent ASCVD events in both stable secondary prevention and acute coronary syndrome populations. Prespecified analyses of recent randomized controlled trials have shed light on how best to prioritize these therapies to maximize their value in select high-risk groups. These data have also informed recent clinical practice guidelines and scientific statements resulting in an expanded role for PCSK9-mAbs compared with previous guidelines, albeit there are notable differences between these recommendations. Ongoing research is exploring the long-term safety of PCSK9-mAbs and their role in the acute setting and patients without prior myocardial infarction or stroke. Novel therapies that inhibit PCSK9 synthesis via small interfering RNA, such as inclisiran, are also in development and may reduce LDL-C levels similar to PCSK9-mAbs, but with less frequent administration. Nonetheless, the PCSK9-mAbs are a breakthrough therapy and warrant consideration in very high-risk patients who are most likely to benefit. Such a personalized approach can help to ensure cost-effectiveness and maximize their value.
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
  • Thrombocytopenia During Prostacyclin Analogue Therapies of Pulmonary
           Arterial Hypertension—Possible Pathomechanisms and Implications
    • Authors: Grzesk; Grzegorz; Karasek, Danuta; Kusiak, Mateusz
      Abstract: image : Pulmonary arterial hypertension is a quite rare, but problematic disease in everyday cardiologists' practice. Prostanoids are the most important group of drugs used in this disease. One of the biggest problems encountered during treatment with analogs of prostacyclin is thrombocytopenia. Based on hematological guidelines we suggest common therapeutic schemes depending on the number of platelets or the severity of bleeding conducting the therapy.
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
  • Predictors of Statin Intolerance in Patients With a New Diagnosis of
           Atherosclerotic Cardiovascular Disease Within a Large Integrated Health
           Care Institution: The IMPRES Study
    • Authors: Bair; Tami L.; May, Heidi T.; Knowlton, Kirk U.; Anderson, Jeffrey L.; Lappe, Donald L.; Muhlestein, Joseph B.
      Abstract: image : Statins are among the most prescribed medications because of the well-documented benefits of safely lowering low-density lipoprotein cholesterol. However, many patients are unable or unwilling to continue statin therapy because of real or perceived adverse effects. This study sought to increase understanding about which patients are unlikely to tolerate statin therapy. The Intermountain Healthcare's electronic data repository was queried from January 1, 1999, to December 31, 2013, to identify all adults who survived their first encounter of coronary artery disease (CAD), cerebral vascular disease, or peripheral artery disease and received statin therapy during follow-up. Statin intolerance (SI) was identified by the documentation of clinician-noted intolerance or allergy or by the use of pitavastatin. Patients were followed up for ≥3 years or until death. Of the 48,997 patients evaluated, 3049 (6.2%) were documented with SI. Of those with SI, 9.8% were prescribed a low-intensity, 73.4% a moderate-intensity, and 16.8% a high-intensity statin dose. After adjustment for covariables, significant predictors of SI were female sex [odds ratio (OR) = 1.47, P < 0.0001], age (65–74 vs.
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
  • Low-Intensity Ultrasound Modulation May Prevent Myocardial
           Infarction-induced Sympathetic Neural Activation and Ventricular
    • Authors: Wang; Songyun; Li, Binxun; Li, Xuemeng; Wu, Lin; Zhu, Tongjian; Zhao, Dongdong; Jiang, Hong
      Abstract: imageBackground: Low-intensity focused ultrasound (LIFU) has been shown to be a beneficial tool for autonomic nervous system modulation, but its effect on the left stellate ganglion (LSG) remains unknown.Objective: To seek the effect of LIFU on myocardial infarction (MI)-induced LSG activation and ventricular arrhythmias (VAs).Methods: In this study, 20 dogs were included and randomly divided into the LIFU (LIFU & MI, n = 8), Sham (sham LIFU & MI, n = 8), and Control group (sham LIFU & sham MI, n = 4). For each LIFU intervention (1.0–2.0 W, 10 minutes) of the LSG, the LSG function, ventricular effective refractory period (ERP), and temperature were tested pre-intervention and postintervention. Thereafter, MI was induced by left anterior artery ligation and VAs were recorded for 1 hour. At the end, both the LSG and the heart were extracted for biomedical and histological analysis.Results: In the Sham group, no significant change was shown in ventricular ERP or LSG function for any intensity settings of sham LIFU intervention when compared with the group baseline. In the LIFU group, however, both 1.5 and 2.0 W LIFU modulation of LSG resulted in significant prolongation of ERP and attenuation of LSG function. Furthermore, the incidence of VAs was significantly attenuated in the LIFU group compared with the Sham group. Moreover, histological analysis showed that no damage or apoptosis was observed in LSG although a statistically significant increase was shown in temperature (maximal increase
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
  • Case–Control Study on the Interaction Effects of rs10757278
           Polymorphisms at 9p21 Locus and Traditional Risk Factors on Coronary Heart
           Disease in Xinjiang, China
    • Authors: Lu; Wu-Hong; Zhang, Wen-Qian; Zhao, Yun-Juan; Gao, Ya-Ting; Tao, Ning; Ma, Yi-Tong; Liu, Ji-Wen; Wulasihan, Muhuyati
      Abstract: imageObjective: To study the interaction effects of rs10757278 polymorphisms at 9p21 locus and traditional risk factors on coronary heart disease (CHD) in Xinjiang, China.Methods: This case–control study consecutively enrolled 310 unrelated consecutive CHD patients aged 18–70 years old. All study participants were recruited between January and December 2017 from The Heart Center of The First Affiliated Hospital of Xinjiang Medical University. CHD patients were confirmed by coronary angiography (≥50% diameter stenosis in at least one of the major coronary arteries) according to the American Heart Association criteria for the confirmation of CHD. Healthy subjects were randomly selected from the occupational population, who received physical examination in our hospital and matched to cases on the basis of age (±3 years) and sex, those without medical history of cardiovascular diseases, and 536 subjects were selected as the control group after medical history inquiry, physical examination, cardiac ultrasound, electrocardiogram, and other blood biochemical examinations in the hospital. The occupational stress was evaluated by an effort-reward imbalance questionnaire. An epidemiological survey was conducted to collect clinical data. Chi-squared test, analysis of variance, and binary logistic regression analysis were adopted.Results: Both the case and the control groups showed significant difference in smoking, drinking, physical activity, hypertension, diabetes mellitus, family history of CHD, and body mass index (BMI) (all P < 0.05); prevalence of CHD was not related to occupational stress. There was no significant difference in occupational stress level between the 2 groups (P> 0.05); Differences in rs10757278 genotype between the case group and the control groups were statistically significant; binary logistic regression analysis was used to evaluate the risk factors of CHD. After adjustment for age and sex, significant increased risk effects for CHD were found to be associated with smoking [odds ratio (OR) = 2.311; 95% confidence interval (CI): 1.04–2.499; P < 0.001], physical exercise (OR = 1.365; 95% CI: 1.137–1.639; P < 0.001), hypertension (OR = 4.627; 95% CI: 2.165–10.764; P < 0.001), family history of CHD (OR = 4.103; 95% CI: 3.169–6.892; P < 0.001), BMI (OR = 2.484; 95% CI: 2.036–3.03; P < 0.001), and GG genotype at rs10757278 (OR = 1.978; 95% CI: 1.413–2.769; P < 0.001); We noted that a significant interaction association between GG genotype at rs10757278 and CHD differs across categories of smoking, hypertension, family history of CHD, and BMI.Conclusion: GG genotype at rs10757278 may be a risk factor for CHD. And there are interaction effects between GG genotype of rs10757278 in region 9p21 gene and traditional risk factors.
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
  • miR-4286/TGF-β1/Smad3-Negative Feedback Loop Ameliorated Vascular
           Endothelial Cell Damage by Attenuating Apoptosis and Inflammatory Response
    • Authors: He; Zhiyu; Xue, Hao; Liu, Peiying; Han, Dunzheng; Xu, Lingling; Zeng, Xiaojun; Wang, Jinping; Yang, Biqing; Luo, Bihui
      Abstract: image : Atherosclerosis (AS), known as the chronic inflammatory disease, results from the dysfunction of vascular endothelial cells (VECs). Transforming growth factor-β1 (TGF-β1) has been reported to be induced by oxidized low-density lipoprotein (ox-LDL) and contribute to AS-related vascular endothelial cell damage. This work planned to study the mechanism of TGF-β1 in vascular endothelial cell damage. We found that TGF-β1 was activated by ox-LDL in human umbilical vascular endothelial cells (HUVECs). Silence of TGF-β1 reversed the inductive effect of ox-LDL on apoptosis and inflammatory response of HUVECs. Mechanistically, microRNA-4286 (miR-4286) targeted and inhibited TGF-β1 to inhibit Smad3, and Smad3 bound to the promoter of miR-4286 to repress its transcription. Rescue assays indicated that miR-4286 ameliorated the ox-LDL-induced apoptosis and inflammatory response through inhibiting TGF-β1. In conclusion, our study first demonstrated that miR-4286/TGF-β1/Smad3-negative feedback loop ameliorated vascular endothelial cell damage by attenuating apoptosis and inflammatory response, providing new thoughts for promoting the treatment of AS.
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
  • Comparison of Positive Inotropic Agents in the Management of Acute
           Decompensated Heart Failure
    • Authors: Kelly; Julie; Cheng, Judy; Malloy, Rhynn; Lupi, Kenneth
      Abstract: image : Current guidelines recommend the consideration of positive inotropes in patients with acute decompensated heart failure (ADHF) who have low cardiac index and evidence of systemic hypoperfusion or congestion. However, there is no evidence detailing the first line agent for the management of ADHF. The purpose of this study was to compare the safety and efficacy of dobutamine to milrinone for the treatment of ADHF. This was a single-center, retrospective study at a tertiary academic medical center, approved by Partner's Health Care Institutional Review Board. Patients included in this study were those admitted with ADHF who received dobutamine or milrinone from June 2015 to July 2017. A total of 95 dobutamine and 40 milrinone patients were included in the analysis. Median hospital length of stay was 12 days in the dobutamine group versus 10 days in the milrinone group (P = 0.34). Rehospitalization within 30 days occurred in 29.5% of patients in the dobutamine group versus 17.5% of patients in the milrinone group (P = 0.15). Median intensive care unit length of stay was 4.5 days in the dobutamine group versus 10 days in the milrinone group (P < 0.01). All other minor end points including all-cause mortality, progression to renal failure within 72 hours, rehospitalization in 90 days, and urine output within 72 hours of therapy were not found to be statistically significant. In addition, a post hoc analysis compared major and minor outcomes between milrinone and dobutamine using linear and logistic regression with adjustment for baseline characteristics. There were not any statistically significant findings in the post hoc analysis. Overall, there were no statistically significant differences in outcomes between the 2 groups other than longer intensive care unit length of stay in the milrinone group.
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
  • The mKATP Channels and protein-kinase C Are Involved in the
           Cardioprotective Effects of Genistein on Estrogen-Deficient Rat Hearts
           Exposed to Ischemia/Reperfusion: Energetic Study
    • Authors: Colareda; Germán A.; Ragone, María Inés; Bonazzola, Patricia; Consolini, Alicia E.
      Abstract: image : Estrogenic deficiency is considered a risk of coronary disease in women. The phytoestrogen genistein could be a safe preventive strategy. The first aim of this work was to validate a model of cardiac stunning in which natural estrogenic deficiency rats, ie, adult young male (YM) and aged female (AgF), are compared with young female rats (YF). The second aim was to study whether the in vivo administration of genistein prevents the stunning in estrogenic deficiency rats. The third aim was to evaluate whether in our estrogenic deficiency model exists a synergy between genistein and estradiol. The fourth aim was to characterize the underlying mechanisms of genistein. Stunning was induced by ischemia/reperfusion (I/R) in isolated hearts inside a calorimeter. The left ventricular pressure (P) and total heat rate (Ht) were simultaneously measured, while diastolic contracture and muscle economy (P/Ht) were calculated. During R, P/Ht and P recovered less in AgF and YM than in YF rat hearts. Genistein through i.p. (GST-ip) improved P and P/Ht in AgF and YM, but not in YF. In YM, the cardioprotections of GST-ip and estradiol were synergistic. After ischemia, GST-ip increased SR Ca2+ leak causing diastolic contracture. The GST-ip cardioprotection neither was affected by blockade of PI3K-Akt, NO synthases, or phosphatases, but it was sensitive to blockade of protein-kinase C and mKATP channels. Results suggest that (1) estrogenic deficiency worsens cardiac stunning, (2) GST-ip was more cardioprotective in estrogenic deficiency and synergistic with estradiol, and (3) cardioprotection of GST-ip depends on the protein-kinase C and mKATP channel pathway activation.
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
  • Nitrate Esters Alleviated Coronary Atherosclerosis Through Inhibition of
           NF-κB–Regulated Macrophage Polarization Shift in Epicardial Adipose
    • Authors: Wei; Chun-Yan; Wang, Yong-Mei; Han, Lu; Chen, Fang-Fang; Li, Yi-Hui; Tang, Meng-Xiong; Zhang, Wei; Wang, Zhi-Hao; Zhong, Ming
      Abstract: image : Nitrate esters have been used in clinical practice for more than one century for the treatment of angina. Their clinical effectiveness is due to vasodilator activity in arteries through a method of delivering nitric oxide or a nitric oxide–like compound. Recently, an increasing numbers of functions of this molecule in biology and pathophysiology have been discovered. Macrophage polarization shift in epicardial adipose tissue (EAT) has been demonstrated to be correlated with the severity of coronary artery disease (CAD). In this study, we aimed to investigate whether nitrate esters could improve coronary atherosclerosis through inhibition of macrophage polarization shift in EAT. A case–control study enrolled 48 subjects in 2 groups: CAD patients with or without nitrate esters treatment. Infiltration of M1/M2 macrophages and the expressions of pro-inflammatory and anti-inflammatory cytokines in EAT and subcutaneous white adipose tissue were investigated by immunohistochemical stain among subjects undergoing coronary artery bypass graft surgery. The expression levels of metabolic genes were investigated by real-time reverse transcription-polymerase chain reaction (RT-PCR). We found that nitrate ester treatment significantly inhibited NF-кB activity and decreased macrophage infiltration and M1/M2 macrophage ratio in EAT in patients with CAD. The expressions of pro-inflammatory cytokines were significantly decreased, along with significantly elevated expressions of anti-inflammatory cytokines in CAD patients with nitrate ester treatment, corresponding EAT dysfunction was ameliorated and the severity of patients with CAD (Gensini score) was significantly decreased. The protective effects on macrophage polarization and EAT function through NF-кB activity inhibition suggested a potential mechanism of nitrate esters in alleviating the severity of CAD.
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
  • [Retracted] Physcion8-O-Β-Glucopyranoside Alleviates Oxidized Low-Density
           Lipoprotein-Induced Human Umbilical Vein Endothelial Cells Injury by
           Inducing Autophagy Via AMPK/SIRT1 Signaling
    • Abstract: No abstract available
      PubDate: Fri, 01 May 2020 00:00:00 GMT-
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