Publisher: LWW Wolters Kluwer   (Total: 299 journals)

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Showing 1 - 200 of 299 Journals sorted alphabetically
A&A Case Reports     Hybrid Journal   (Followers: 2, SJR: 0.278, CiteScore: 1)
Academic Medicine     Hybrid Journal   (Followers: 74, SJR: 2.53, CiteScore: 2)
ACG Case Reports J.     Open Access  
ACSMs Health & Fitness J.     Full-text available via subscription   (Followers: 15, SJR: 0.207, CiteScore: 0)
Addictive Disorders & Their Treatment     Hybrid Journal   (Followers: 5, SJR: 0.191, CiteScore: 0)
Advanced Emergency Nursing J.     Hybrid Journal   (Followers: 39, SJR: 0.235, CiteScore: 1)
Advances in Anatomic Pathology     Hybrid Journal   (Followers: 21, SJR: 1.012, CiteScore: 3)
Advances in Neonatal Care     Hybrid Journal   (Followers: 47, SJR: 0.438, CiteScore: 1)
Advances in Nursing Science     Hybrid Journal   (Followers: 38, SJR: 0.343, CiteScore: 1)
Advances in Skin & Wound Care     Hybrid Journal   (Followers: 29, SJR: 0.563, CiteScore: 1)
Adverse Drug Reaction Bulletin     Full-text available via subscription   (Followers: 5, SJR: 0.12, CiteScore: 0)
AIDS     Hybrid Journal   (Followers: 23, SJR: 2.919, CiteScore: 4)
AJSP: Reviews & Reports     Hybrid Journal  
Alzheimer Disease & Associated Disorders     Hybrid Journal   (Followers: 19, SJR: 1.157, CiteScore: 2)
American J. of Clinical Oncology     Hybrid Journal   (Followers: 60, SJR: 0.973, CiteScore: 2)
American J. of Dermatopathology     Hybrid Journal   (Followers: 17, SJR: 0.6, CiteScore: 1)
American J. of Forensic Medicine and Pathology     Hybrid Journal   (Followers: 29, SJR: 0.363, CiteScore: 1)
American J. of Gastroenterology, The     Hybrid Journal   (Followers: 175, SJR: 4.197, CiteScore: 5)
American J. of Nursing     Hybrid Journal   (Followers: 80, SJR: 0.284, CiteScore: 0)
American J. of Physical Medicine & Rehabilitation     Hybrid Journal   (Followers: 58, SJR: 0.636, CiteScore: 1)
American J. of Surgical Pathology     Hybrid Journal   (Followers: 38, SJR: 2.531, CiteScore: 6)
American J. of Therapeutics     Hybrid Journal   (Followers: 14, SJR: 0.399, CiteScore: 1)
Anesthesia & Analgesia     Hybrid Journal   (Followers: 254, SJR: 1.472, CiteScore: 3)
Anesthesiology     Hybrid Journal   (Followers: 229, SJR: 2.123, CiteScore: 3)
Annals of Plastic Surgery     Hybrid Journal   (Followers: 22, SJR: 0.893, CiteScore: 1)
Annals of Surgery     Hybrid Journal   (Followers: 77, SJR: 4.361, CiteScore: 5)
Anti-Cancer Drugs     Hybrid Journal   (Followers: 5, SJR: 0.716, CiteScore: 2)
Applied Immunohistochemistry & Molecular Morphology     Hybrid Journal   (Followers: 17, SJR: 0.765, CiteScore: 1)
ASAIO J.     Hybrid Journal   (Followers: 3, SJR: 0.771, CiteScore: 2)
Asia-Pacific J. of Ophthalmology     Full-text available via subscription   (Followers: 3, SJR: 0.64, CiteScore: 1)
Behavioural Pharmacology     Hybrid Journal   (Followers: 2, SJR: 0.916, CiteScore: 2)
Biomedical Safety & Standards     Full-text available via subscription   (Followers: 8)
Blood Coagulation & Fibrinolysis     Hybrid Journal   (Followers: 61, SJR: 0.438, CiteScore: 1)
Blood Pressure Monitoring     Hybrid Journal   (Followers: 1, SJR: 0.537, CiteScore: 1)
Brain & Life     Full-text available via subscription   (Followers: 3)
Canadian J. of Addiction     Hybrid Journal   (Followers: 1)
Cancer J.     Full-text available via subscription   (Followers: 8, SJR: 1.893, CiteScore: 4)
Cancer Nursing     Hybrid Journal   (Followers: 33, SJR: 0.858, CiteScore: 2)
Cardiology in Review     Hybrid Journal   (Followers: 8, SJR: 0.863, CiteScore: 2)
Cardiopulmonary Physical Therapy J.     Hybrid Journal   (Followers: 8)
Cardiovascular Endocrinology & Metabolism     Hybrid Journal   (Followers: 1, SJR: 0.165, CiteScore: 0)
CIN : Computers Informatics Nursing     Hybrid Journal   (Followers: 11, SJR: 0.359, CiteScore: 1)
Clinical and Translational Gastroenterology     Open Access   (SJR: 1.844, CiteScore: 4)
Clinical Dysmorphology     Hybrid Journal   (SJR: 0.268, CiteScore: 0)
Clinical J. of Pain     Hybrid Journal   (Followers: 18, SJR: 1.406, CiteScore: 3)
Clinical J. of Sport Medicine     Hybrid Journal   (Followers: 35, SJR: 0.999, CiteScore: 2)
Clinical Neuropharmacology     Hybrid Journal   (Followers: 3, SJR: 0.506, CiteScore: 1)
Clinical Nuclear Medicine     Hybrid Journal   (Followers: 2, SJR: 0.652, CiteScore: 1)
Clinical Nurse Specialist     Hybrid Journal   (Followers: 28, SJR: 0.256, CiteScore: 0)
Clinical Nutrition Insight     Full-text available via subscription   (Followers: 14)
Clinical Obstetrics & Gynecology     Full-text available via subscription   (Followers: 27, SJR: 0.588, CiteScore: 1)
Clinical Orthopaedics and Related Research     Hybrid Journal   (Followers: 97, SJR: 1.908, CiteScore: 3)
Clinical Pulmonary Medicine     Hybrid Journal   (Followers: 2, SJR: 0.215, CiteScore: 0)
Clinical Spine Surgery     Hybrid Journal   (Followers: 2, SJR: 0.738, CiteScore: 1)
Cognitive and Behavioral Neurology     Hybrid Journal   (Followers: 9, SJR: 0.565, CiteScore: 1)
Colombian J. of Anesthesiology : Revista Colombiana de Anestesiología     Hybrid Journal  
Contemporary Diagnostic Radiology     Full-text available via subscription   (Followers: 3)
Contemporary Neurosurgery     Full-text available via subscription   (Followers: 3)
Contemporary Spine Surgery     Full-text available via subscription   (Followers: 4)
Continuum : Lifelong Learning in Neurology     Hybrid Journal   (Followers: 9, SJR: 0.618, CiteScore: 1)
Cornea     Hybrid Journal   (Followers: 12, SJR: 1.578, CiteScore: 2)
Coronary Artery Disease     Hybrid Journal   (Followers: 2, SJR: 0.705, CiteScore: 1)
Critical Care Explorations     Open Access   (Followers: 1)
Critical Care Medicine     Hybrid Journal   (Followers: 359, SJR: 3.116, CiteScore: 3)
Critical Care Nursing Quarterly     Full-text available via subscription   (Followers: 15, SJR: 0.273, CiteScore: 1)
Critical Pathways in Cardiology     Hybrid Journal   (Followers: 4, SJR: 0.411, CiteScore: 1)
Current Opinion in Allergy and Clinical Immunology     Hybrid Journal   (Followers: 8, SJR: 1.244, CiteScore: 3)
Current Opinion in Anaesthesiology     Hybrid Journal   (Followers: 60, SJR: 0.792, CiteScore: 3)
Current Opinion in Cardiology     Hybrid Journal   (Followers: 14, SJR: 0.97, CiteScore: 2)
Current Opinion in Clinical Nutrition & Metabolic Care     Hybrid Journal   (Followers: 21, SJR: 1.521, CiteScore: 4)
Current Opinion in Critical Care     Hybrid Journal   (Followers: 74, SJR: 1.382, CiteScore: 3)
Current Opinion in Endocrinology, Diabetes and Obesity     Hybrid Journal   (Followers: 51, SJR: 1.467, CiteScore: 3)
Current Opinion in Gastroenterology     Hybrid Journal   (Followers: 15, SJR: 1.515, CiteScore: 3)
Current Opinion in Hematology     Hybrid Journal   (Followers: 18, SJR: 1.588, CiteScore: 3)
Current Opinion in HIV and AIDS     Hybrid Journal   (Followers: 11, SJR: 2.286, CiteScore: 4)
Current Opinion in Infectious Diseases     Hybrid Journal   (Followers: 25, SJR: 1.813, CiteScore: 4)
Current Opinion in Lipidology     Hybrid Journal   (Followers: 6, SJR: 1.847, CiteScore: 3)
Current Opinion in Nephrology & Hypertension     Hybrid Journal   (Followers: 10, SJR: 1.513, CiteScore: 3)
Current Opinion in Neurology     Hybrid Journal   (Followers: 24, SJR: 1.929, CiteScore: 4)
Current Opinion in Obstetrics & Gynecology     Hybrid Journal   (Followers: 13, SJR: 0.992, CiteScore: 3)
Current Opinion in Oncology     Hybrid Journal   (Followers: 24, SJR: 1.217, CiteScore: 3)
Current Opinion in Ophthalmology     Hybrid Journal   (Followers: 31, SJR: 1.434, CiteScore: 3)
Current Opinion in Organ Transplantation     Hybrid Journal   (Followers: 10, SJR: 1.153, CiteScore: 3)
Current Opinion in Otolaryngology & Head & Neck Surgery     Hybrid Journal   (Followers: 12, SJR: 0.683, CiteScore: 2)
Current Opinion in Pediatrics     Hybrid Journal   (Followers: 47, SJR: 1.128, CiteScore: 3)
Current Opinion in Psychiatry     Hybrid Journal   (Followers: 53, SJR: 1.745, CiteScore: 4)
Current Opinion in Pulmonary Medicine     Hybrid Journal   (Followers: 10, SJR: 1.092, CiteScore: 3)
Current Opinion in Rheumatology     Hybrid Journal   (Followers: 18, SJR: 2.187, CiteScore: 4)
Current Opinion in Supportive and Palliative Care     Hybrid Journal   (Followers: 25, SJR: 0.558, CiteScore: 2)
Current Opinion in Urology     Hybrid Journal   (Followers: 11, SJR: 0.949, CiteScore: 2)
Current Orthopaedic Practice     Hybrid Journal   (Followers: 13, SJR: 0.143, CiteScore: 0)
Current Sports Medicine Reports     Full-text available via subscription   (Followers: 22, SJR: 0.448, CiteScore: 1)
Dermatitis     Hybrid Journal   (Followers: 1, SJR: 0.751, CiteScore: 2)
Dermatologic Surgery     Hybrid Journal   (Followers: 8, SJR: 1.168, CiteScore: 1)
Dimensions of Critical Care Nursing     Full-text available via subscription   (Followers: 9, SJR: 0.467, CiteScore: 1)
Diseases of the Colon & Rectum     Hybrid Journal   (Followers: 36, SJR: 1.647, CiteScore: 3)
Ear & Hearing     Hybrid Journal   (Followers: 15, SJR: 1.735, CiteScore: 3)
Egyptian J. of Histology     Partially Free   (SJR: 0.107, CiteScore: 0)
Egyptian J. of Oral and Maxillofacial Surgery     Partially Free   (Followers: 1)
Egyptian J. of Pathology     Partially Free   (Followers: 1)
Emergency Medicine News     Full-text available via subscription   (Followers: 8)
Environmental Epidemiology     Open Access  
Epidemiology     Hybrid Journal   (Followers: 58, SJR: 2.671, CiteScore: 3)
European J. of Anaesthesiology     Hybrid Journal   (Followers: 30, SJR: 1.179, CiteScore: 2)
European J. of Cancer Prevention     Hybrid Journal   (Followers: 3, SJR: 1.021, CiteScore: 2)
European J. of Emergency Medicine     Hybrid Journal   (Followers: 22, SJR: 0.597, CiteScore: 1)
European J. of Gastroenterology & Hepatology     Hybrid Journal   (Followers: 23, SJR: 0.986, CiteScore: 2)
Exercise and Sport Sciences Reviews     Hybrid Journal   (Followers: 54, SJR: 1.943, CiteScore: 4)
Eye & Contact Lens Science and Clinical Practice     Hybrid Journal   (Followers: 4, SJR: 0.949, CiteScore: 2)
Family & Community Health     Hybrid Journal   (Followers: 14, SJR: 0.539, CiteScore: 1)
Female Pelvic Medicine & Reconstructive Surgery     Hybrid Journal   (Followers: 1, SJR: 0.546, CiteScore: 1)
Gastroenterology Nursing     Hybrid Journal   (Followers: 8, SJR: 0.248, CiteScore: 0)
Global Reproductive Health     Open Access  
Harvard Review of Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.375, CiteScore: 3)
Health Care Management Review     Hybrid Journal   (Followers: 15, SJR: 1.244, CiteScore: 2)
Health Physics     Hybrid Journal   (Followers: 7, SJR: 0.528, CiteScore: 1)
Hearing J.     Full-text available via subscription   (Followers: 5, SJR: 0.123, CiteScore: 0)
HemaSphere     Open Access  
Holistic Nursing Practice     Hybrid Journal   (Followers: 6, SJR: 0.239, CiteScore: 1)
Home Healthcare Now     Hybrid Journal   (Followers: 5, SJR: 0.178, CiteScore: 0)
Human Andrology     Partially Free   (Followers: 2)
IJS Global Health     Open Access  
IJS Oncology     Open Access  
Implant Dentistry     Hybrid Journal   (Followers: 7, SJR: 0.712, CiteScore: 1)
Infants and Young Children     Hybrid Journal   (Followers: 7, SJR: 0.412, CiteScore: 1)
Infectious Diseases in Clinical Practice     Hybrid Journal   (Followers: 12, SJR: 0.177, CiteScore: 0)
Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery     Hybrid Journal   (Followers: 1, SJR: 0.432, CiteScore: 1)
Intl. Anesthesiology Clinics     Hybrid Journal   (Followers: 9, SJR: 0.201, CiteScore: 0)
Intl. Clinical Psychopharmacology     Hybrid Journal   (Followers: 2, SJR: 1.086, CiteScore: 3)
Intl. J. of Evidence-Based Healthcare     Hybrid Journal   (Followers: 8, SJR: 0.931, CiteScore: 2)
Intl. J. of Gynecological Pathology     Hybrid Journal   (Followers: 9, SJR: 0.65, CiteScore: 1)
Intl. J. of Rehabilitation Research     Hybrid Journal   (Followers: 20, SJR: 0.583, CiteScore: 2)
Intl. Ophthalmology Clinics     Hybrid Journal   (Followers: 1, SJR: 0.59, CiteScore: 1)
Investigative Radiology     Hybrid Journal   (Followers: 10, SJR: 3.774, CiteScore: 6)
Itch : Intl. Forum for the Study of Itch     Open Access  
J. for Healthcare Quality     Hybrid Journal   (Followers: 24, SJR: 0.633, CiteScore: 1)
J. for Nurses in Professional Development     Hybrid Journal   (Followers: 13, SJR: 0.491, CiteScore: 1)
J. of Acute Care Physical Therapy     Hybrid Journal   (Followers: 1)
J. of Addiction Medicine     Hybrid Journal   (Followers: 7, SJR: 1.063, CiteScore: 2)
J. of Addictions Nursing     Hybrid Journal   (Followers: 7, SJR: 0.229, CiteScore: 0)
J. of Ambulatory Care Management, The     Hybrid Journal   (Followers: 4, SJR: 0.539, CiteScore: 1)
J. of Bronchology & Interventional Pulmonology     Hybrid Journal   (Followers: 5, SJR: 0.455, CiteScore: 1)
J. of Cardiopulmonary Rehabilitation and Prevention     Hybrid Journal   (Followers: 7, SJR: 0.816, CiteScore: 2)
J. of Cardiovascular Medicine     Hybrid Journal   (Followers: 2, SJR: 0.599, CiteScore: 1)
J. of Cardiovascular Nursing     Hybrid Journal   (Followers: 18, SJR: 0.709, CiteScore: 1)
J. of Cardiovascular Pharmacology     Hybrid Journal   (Followers: 7, SJR: 0.917, CiteScore: 2)
J. of Christian Nursing     Hybrid Journal   (Followers: 2, SJR: 0.137, CiteScore: 0)
J. of Clinical Engineering     Full-text available via subscription   (Followers: 1)
J. of Clinical Gastroenterology     Hybrid Journal   (Followers: 11, SJR: 1.245, CiteScore: 2)
J. of Clinical Neuromuscular Disease     Hybrid Journal   (Followers: 1, SJR: 0.358, CiteScore: 1)
J. of Clinical Neurophysiology     Hybrid Journal   (Followers: 3, SJR: 0.629, CiteScore: 2)
J. of Clinical Psychopharmacology     Hybrid Journal   (Followers: 24, SJR: 1.054, CiteScore: 2)
J. of Computer Assisted Tomography     Hybrid Journal   (Followers: 1, SJR: 0.648, CiteScore: 1)
J. of Continuing Education in the Health Professions     Hybrid Journal   (Followers: 12, SJR: 0.606, CiteScore: 1)
J. of Craniofacial Surgery     Hybrid Journal   (Followers: 4, SJR: 0.448, CiteScore: 1)
J. of Developmental & Behavioral Pediatrics     Hybrid Journal   (Followers: 12, SJR: 1.03, CiteScore: 2)
J. of ECT     Hybrid Journal   (Followers: 14, SJR: 0.822, CiteScore: 2)
J. of Forensic Nursing     Hybrid Journal   (Followers: 7, SJR: 0.33, CiteScore: 1)
J. of Geriatric Physical Therapy     Hybrid Journal   (Followers: 11, SJR: 0.691, CiteScore: 2)
J. of Glaucoma     Hybrid Journal   (Followers: 2, SJR: 1.08, CiteScore: 2)
J. of Head Trauma Rehabilitation     Hybrid Journal   (Followers: 16, SJR: 1.545, CiteScore: 3)
J. of Healthcare Management     Hybrid Journal   (Followers: 12, SJR: 0.562, CiteScore: 1)
J. of Hospice & Palliative Nursing     Hybrid Journal   (Followers: 30, SJR: 0.305, CiteScore: 1)
J. of Hypertension     Hybrid Journal   (Followers: 13, SJR: 1.733, CiteScore: 3)
J. of Immunotherapy     Hybrid Journal   (Followers: 7, SJR: 1.373, CiteScore: 4)
J. of Infusion Nursing     Hybrid Journal   (Followers: 4, SJR: 0.251, CiteScore: 1)
J. of Lower Genital Tract Disease     Hybrid Journal   (SJR: 0.602, CiteScore: 1)
J. of Nervous and Mental Disease     Hybrid Journal   (Followers: 6, SJR: 0.988, CiteScore: 2)
J. of Neuro-Ophthalmology     Hybrid Journal   (Followers: 12, SJR: 0.605, CiteScore: 1)
J. of Neurologic Physical Therapy     Hybrid Journal   (Followers: 10, SJR: 1.227, CiteScore: 3)
J. of Neuroscience Nursing     Hybrid Journal   (Followers: 8, SJR: 0.388, CiteScore: 1)
J. of Neurosurgical Anesthesiology     Hybrid Journal   (Followers: 8, SJR: 0.914, CiteScore: 2)
J. of Nursing Administration     Hybrid Journal   (Followers: 32, SJR: 0.727, CiteScore: 1)
J. of Nursing Care Quality     Hybrid Journal   (Followers: 22, SJR: 0.772, CiteScore: 1)
J. of Nursing Research     Open Access   (Followers: 21, SJR: 0.492, CiteScore: 1)
J. of Occupational & Environmental Medicine     Hybrid Journal   (Followers: 22, SJR: 0.812, CiteScore: 1)
J. of Orthopaedic Trauma     Hybrid Journal   (Followers: 19, SJR: 1.451, CiteScore: 2)
J. of Patient Safety     Hybrid Journal   (Followers: 15, SJR: 0.648, CiteScore: 1)
J. of Pediatric Gastroenterology and Nutrition (JPGN)     Hybrid Journal   (Followers: 49, SJR: 1.376, CiteScore: 2)
J. of Pediatric Hematology/Oncology     Hybrid Journal   (Followers: 6, SJR: 0.459, CiteScore: 1)
J. of Pediatric Orthopaedics     Hybrid Journal   (Followers: 14, SJR: 0.913, CiteScore: 2)
J. of Pediatric Orthopaedics B     Hybrid Journal   (Followers: 5, SJR: 0.356, CiteScore: 1)
J. of Pediatric Surgical Nursing     Hybrid Journal   (SJR: 0.123, CiteScore: 0)
J. of Perinatal & Neonatal Nursing     Hybrid Journal   (Followers: 16, SJR: 0.347, CiteScore: 1)
J. of Physical Therapy Education     Hybrid Journal   (Followers: 15)
J. of Prosthetics and Orthotics     Hybrid Journal   (Followers: 13, SJR: 0.214, CiteScore: 0)
J. of Psychiatric Practice     Hybrid Journal   (Followers: 2, SJR: 0.757, CiteScore: 1)
J. of Public Health Management and Practice     Hybrid Journal   (Followers: 5, SJR: 0.797, CiteScore: 1)
J. of Spinal Disorders & Techniques     Hybrid Journal   (Followers: 2, SJR: 1.115, CiteScore: 2)
J. of Strength and Conditioning Research     Hybrid Journal   (Followers: 75, SJR: 1.366, CiteScore: 2)
J. of the American Association of Nurse Practitioners     Hybrid Journal   (Followers: 7)
J. of the Dermatology Nurses' Association     Hybrid Journal   (Followers: 3, SJR: 0.175, CiteScore: 0)
J. of the Egyptian Women’s Dermatologic Society     Partially Free   (SJR: 0.119, CiteScore: 0)
J. of Thoracic Imaging     Hybrid Journal   (Followers: 3, SJR: 0.705, CiteScore: 2)
J. of Trauma and Acute Care Surgery, The     Hybrid Journal   (Followers: 33, SJR: 1.747, CiteScore: 3)
J. of Trauma Nursing     Hybrid Journal   (Followers: 14, SJR: 0.251, CiteScore: 0)
J. of Trauma, The     Full-text available via subscription   (Followers: 22)
J. of Women’s Health Physical Therapy     Partially Free   (Followers: 5)
J. of Wound Ostomy & Continence Nursing     Hybrid Journal   (Followers: 18, SJR: 0.613, CiteScore: 1)
JAAOS : Global Research & Reviews     Open Access   (Followers: 1)

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Similar Journals
Journal Cover
Current Opinion in Obstetrics & Gynecology
Journal Prestige (SJR): 0.992
Citation Impact (citeScore): 3
Number of Followers: 13  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1040-872X - ISSN (Online) 1473-656X
Published by LWW Wolters Kluwer Homepage  [299 journals]
  • Editorial introductions
    • Abstract: imageNo abstract available
      PubDate: Mon, 01 Jun 2020 00:00:00 GMT-
       
  • Editorial: Challenges in ART diagnostics
    • Authors: Garcia Velasco; Juan A.; Seli, Emre
      Abstract: No abstract available
      PubDate: Mon, 01 Jun 2020 00:00:00 GMT-
       
  • The vaginal microbiome as a tool to predict IVF success
    • Authors: Schoenmakers; Sam; Laven, Joop
      Abstract: imagePurpose of review Herein, we present an overview of the recent microbiome research and findings within the field of reproductive medicine and its relation with the outcome of Assisted reproductive technology (ART). Analyses of the microbiome composition all throughout the female reproductive trace during the process of assisted reproductive techniques are discussed.Recent findings Only the vaginal microbiome can be sampled without possible risks of contamination. Although this also seems to apply to the cervical microbiome, collection has to be performed with extreme caution. Because of the high risk of cross contamination, results of microbial composition of all other sites of the female reproductive tract have to be interpreted with caution. The vaginal composition prior to the start of hormonal treatment for ART seems to be predictive of in vitro fertilization/in vitro fertilization-intracytoplasmic sperm injection (IVF/IVF-ICSI) outcome, with mainly a highly negative predictive value.Summary The local microbiota, especially the absence or presence of specific microbes, within parts of the female reproductive tract seem to be associated with the outcome of ART.
      PubDate: Mon, 01 Jun 2020 00:00:00 GMT-
       
  • Extracellular vesicles as a potential diagnostic tool in assisted
           reproduction
    • Authors: Giacomini; Elisa; Makieva, Sofia; Murdica, Valentina; Vago, Riccardo; Viganó, Paola
      Abstract: imagePurpose of review Extracellular vesicles have emerged as a promising field of research for their potential to serve as biomarkers. In the pathophysiology of reproduction, they have attracted significant attention because of their diverse roles in gametogenesis and embryo-endometrial cross-talk. Advances in extracellular vesicle translational potential are herein reviewed with a particular focus in oocyte competence, semen quality diagnostics, embryo selection and detection of endometrial receptivity.Recent findings Specific miRNAs present in follicular fluid-derived extracellular vesicles have been associated with follicle development and oocyte maturation. Some proteins known to regulate sperm function and capacitation such as glycodelin, and CRISP1 have been found as overrepresented in semen exosomes isolated from severe asthenozoospermic compared to normozoospermic men. In vitro developed human embryos can secrete extracellular vesicles whose propitiousness for preimplantation genetic testing is being increasingly investigated. Endometrial cell-derived extracellular vesicles recovered from uterine flushings might represent a reservoir of molecular markers potentially exploited for monitoring the endometrial status.Summary Accumulated knowledge on extracellular vesicles deriving from endometrium, follicular fluid, embryos or male reproductive system may be translated to clinical practice to inform diagnostics in assisted reproduction technology (ART). Validation studies and technology developments are required to implement the profiling of extracellular vesicles as diagnostic tests in ART.
      PubDate: Mon, 01 Jun 2020 00:00:00 GMT-
       
  • Testing the endometrium: is there enough evidence to justify clinical
           use'
    • Authors: Rahmati; Mona; Macklon, Nick
      Abstract: imagePurpose of review Embryo implantation remains the limiting factor in assisted reproduction outcomes. To date research has mainly focused on improving embryo quality, numbers and selection as the route to improve treatment results. However, with success rates plateauing, interest in the possibility of modulating the endometrial factor is increasing, and a number of biomarkers are now available that offer the possibility of assessing endometrial function.Recent findings In this review, we review recent evidence for the efficacy of a number of these biomarkers, with emphasis on those that aim to enable improvement in embryo/endometrial developmental synchrony endometrium and that offer an assessment of the degree of immune activation of the endometrium. The emerging field of reproductive tract microbiome analysis is also considered. Finally, nascent biomarkers of materno-foetal dialogue, including noncoding RNAs, microvesicles and endometrial glycans are discussed.Summary Tests of potential clinical value are emerging, but further validation studies are required. The usage of innovative endometrial biomarkers provides the possibility of targeted therapies rather than the blind empirical approaches to face embryo implantation failure. It also enables the possibility of randomized controlled trials of interventions targeting the individual cause rather empirical treatments of undiagnosed recurrent implantation failure.
      PubDate: Mon, 01 Jun 2020 00:00:00 GMT-
       
  • Oocyte activation, oolemma piercing, and real-time viability confirmation
           in human oocytes using electrophysiological techniques
    • Authors: Mor; Amir; Seli, Emre
      Abstract: imagePurpose of review To discuss the recent applications of electrophysiological principles to the optimization and automation of the IVF laboratory.Recent findings There is growing evidence showing improvement of live birth rates following oocyte electro-activation. Novel applications using electrophysiological techniques are now employed to determine oocyte penetration and viability in real-time.Summary In this short review, we summarize the recent advances in the integration of electrophysiological techniques into the assisted reproductive technology laboratories. We describe the potential clinical applications and their advantages such as creation of reliable automated cell injection systems and novel manual intracytoplasmic sperm injection (ICSI) training platforms. We also discuss theoretical adverse effects and ways to mitigate them.
      PubDate: Mon, 01 Jun 2020 00:00:00 GMT-
       
  • Determining diagnostic criteria and cause of recurrent implantation
           failure
    • Authors: Cakiroglu; Yigit; Tiras, Bulent
      Abstract: imagePurpose of review Recurrent implantation failure (RIF) refers to the absence of implantation after repeated transfer of good embryos into a normal uterus. This review discusses the diagnostic criteria and cause of RIF.Recent findings Regardless of the advancements in IVF practice, RIF is still a challenge that has to be solved. Exact definition of RIF is lacking today. For the initial evaluation, a rigorous algorithmic evaluation should be compromised with an individualized principle. Factors that might affect the number and quality of the oocyte and sperm cells should be investigated in order to obtain a good-quality embryo. Embryo assessment should be performed under ideal laboratory circumstances. The uterine environment should be carefully evaluated and the embryo should be transferred into the uterus at the most receptive time. Some of the newly introduced diseases and empirical treatment strategies, such as chronic endometritis, vaginal microbiota, immunologic profile and immunomodulator treatments, can be discussed with the couple under the light of adequate evidence-based information.Summary New diagnostic and treatment modalities are needed to be introduced, which would be safe, efficient and efficacious after well-designed randomized controlled trials.
      PubDate: Mon, 01 Jun 2020 00:00:00 GMT-
       
  • Mitochondrial function in women with polycystic ovary syndrome
    • Authors: Cozzolino; Mauro; Seli, Emre
      Abstract: imagePurpose of review To provide an overview of mitochondrial functional alterations in women with polycystic ovary syndrome (PCOS).Recent findings Although numerous studies have focused on PCOS, the pathophysiological mechanisms that cause this common disease remain unclear. Mitochondria play a central role in energy production, and mitochondrial dysfunction may underlie several abnormalities observed in women with PCOS. Recent studies associated mtDNA mutations and low mtDNA copy number with PCOS, and set out to characterize the potential protective role of mitochondrial and endoplasmic reticulum unfolded protein responses (UPRmt and UPRer).Summary Mitochondrial dysfunction likely plays a role in the pathogenesis of PCOS by increasing reactive oxygen (ROS) and oxidative stress. This occurs in a metabolic milieu often affected by insulin resistance, which is a common finding in women with PCOS, especially in those who are overweight or obese. Mutations in mtDNA and low mtDNA copy number are found in these patients and may have potential as diagnostic modalities for specific PCOS phenotypes. More recently, UPRer and UPRmt are being investigated as potential cellular rescue mechanisms in PCOS, the failure of which may lead to apoptosis, and contribute to decreased reproductive potential.
      PubDate: Mon, 01 Jun 2020 00:00:00 GMT-
       
  • Frozen embryo transfer and preeclampsia: where is the link'
    • Authors: Dall’Agnol; Henrique; García Velasco, Juan A.
      Abstract: imagePurpose of review Preeclampsia is the leading cause of maternal death and has a higher incidence in patients undergoing assisted reproduction treatments. New studies about the mechanisms by which it is more frequent in this population have emerged. The purpose of this review is to gather current information about the available results on this correlation and its possible physiopathology.Recent findings Recent publications on the physiopathology of preeclampsia indicate that the corpus luteum is the main source of hormonal production until placental formation and that apart from the secretion of estrogen and progesterone, corpus luteum also produces important substances involved in maternal circulatory adaptation, such as relaxin.With the recent increasing number of frozen embryos transfer in natural cycles or under hormonal replacement, this adaptive circulatory process may be unbalanced and predispose this population to preeclampsia.Summary This article provides a review of frozen embryo transfer and available protocols, the highest incidence of gestational hypertensive disorders presented by the infertile population and an overview of the possible impact of the absence of corpus luteum on the genesis of this disease.
      PubDate: Mon, 01 Jun 2020 00:00:00 GMT-
       
  • Anti-Müllerian hormone as a qualitative marker – or just
           quantity'
    • Authors: Kotlyar; Alexander; Seifer, David B.
      Abstract: imagePurpose of review In this review, we will summarize research looking into anti-Müllerian hormone (AMH) as a measure of oocyte quality.Recent findings AMH is a key factor involved in embryogenesis but also in the development of early follicles. Owing to its relatively small inter and intracycle variability, it has become a widely used method of ovarian reserve testing. In the realm of assisted reproductive technology, it has demonstrated a reliable ability to gauge the number of oocytes obtained during an in-vitro fertilization cycle. For these purposes, AMH is a readily measured quantitative tool. However, its qualitative role is as yet undefined.Summary Although levels of this hormone have been associated with fertilization, blastulation, implantation, and clinical pregnancy rates, there is no clear link with live-birth rates. Furthermore, AMH levels do not appear to correspond with risk of fetal trisomy. AMH does show significant predictive value for the risk of premature ovarian insufficiency and time to onset of menopause.
      PubDate: Mon, 01 Jun 2020 00:00:00 GMT-
       
  • Preconception diet, fertility, and later health in pregnancy
    • Authors: Grieger; Jessica A.
      Abstract: imagePurpose of review Women should enter pregnancy in the best possible health. There is increasing recognition of the importance of nutrition for reproductive health; however, key dietary factors in relation to optimizing fertility are nonexistent. The purpose of this review is to investigate dietary factors, preconception, and the association with fertility and later health in pregnancy.Recent findings This article summarizes recent literature assessing preconception dietary intake and the association with fertility, time to pregnancy, and also the relationship with polycystic ovary syndrome and gestational diabetes; these conditions associate with each other, and also with infertility. The impact of paternal diet is also reported.Summary There is recent interest investigating diet and time to pregnancy, suggesting higher intakes of fruit, minimal intake of fast food and sugar sweetened beverages, and a diet lower in glycemic load, may improve time to pregnancy. There is minimal recent literature on paternal diet and impact on fertility. Present advice to women with polycystic ovary syndrome is in line with international recommendations for lifestyle management to improve reproductive outcomes; and for gestational diabetes, prepregnancy may be an optimal time to improve dietary intakes, particularly through consumption of an overall healthy dietary pattern or a Mediterranean-style dietary pattern.
      PubDate: Mon, 01 Jun 2020 00:00:00 GMT-
       
  • Impact of underlying stress in infertility
    • Authors: Santa-Cruz; Diana C.; Agudo, David
      Abstract: imagePurpose of review To review the latest findings about the impact of women's physiological stress on fertility treatment outcomes and the main biomarkers used.Recent findings Women with infertility report high levels of distress that can impact their treatment outcome. The combination of multiple methodologies in psychological stress evaluation result in higher validity, precision and richness in the data. Hair cortisol levels seem to be a promising biomarker to be associated to treatment outcomes.Summary The impact of distress on treatment outcome can be assessed with the help of biomarkers. Decreasing burden of treatment may lead to relevant improvements in assisted reproductive technology outcome.
      PubDate: Mon, 01 Jun 2020 00:00:00 GMT-
       
 
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