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Publisher: Springer-Verlag   (Total: 2335 journals)

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Showing 1201 - 1400 of 2335 Journals sorted alphabetically
J. of Community Health     Hybrid Journal   (Followers: 8, SJR: 0.921, h-index: 44)
J. of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology     Hybrid Journal   (Followers: 7, SJR: 1.087, h-index: 74)
J. of Comparative Physiology B : Biochemical, Systemic, and Environmental Physiology     Hybrid Journal   (Followers: 4, SJR: 1.126, h-index: 59)
J. of Compassionate Health Care     Open Access   (Followers: 1)
J. of Computational Analysis and Applications     Hybrid Journal   (SJR: 0.291, h-index: 19)
J. of Computational Electronics     Hybrid Journal   (Followers: 4, SJR: 0.511, h-index: 20)
J. of Computational Neuroscience     Hybrid Journal   (Followers: 24, SJR: 1.068, h-index: 60)
J. of Computer and Systems Sciences Intl.     Hybrid Journal   (SJR: 0.27, h-index: 13)
J. of Computer Science and Technology     Open Access   (Followers: 5, SJR: 0.437, h-index: 31)
J. of Computer Virology and Hacking Techniques     Hybrid Journal   (Followers: 6, SJR: 0.151, h-index: 2)
J. of Computer-Aided Molecular Design     Hybrid Journal   (Followers: 3, SJR: 0.995, h-index: 78)
J. of Computers in Education     Hybrid Journal   (Followers: 8)
J. of Computing in Higher Education     Hybrid Journal   (Followers: 13, SJR: 0.363, h-index: 21)
J. of Consumer Policy     Hybrid Journal   (Followers: 6, SJR: 0.704, h-index: 30)
J. of Contemporary Mathematical Analysis     Hybrid Journal   (SJR: 0.237, h-index: 5)
J. of Contemporary Physics (Armenian Academy of Sciences)     Hybrid Journal   (Followers: 11, SJR: 0.197, h-index: 6)
J. of Contemporary Psychotherapy     Hybrid Journal   (Followers: 5, SJR: 0.397, h-index: 23)
J. of Control Theory and Applications     Hybrid Journal   (Followers: 2, SJR: 0.359, h-index: 19)
J. of Control, Automation and Electrical Systems     Hybrid Journal   (Followers: 8, SJR: 0.231, h-index: 9)
J. of Crop Science and Biotechnology     Hybrid Journal   (Followers: 7)
J. of Cross-Cultural Gerontology     Hybrid Journal   (Followers: 5, SJR: 0.631, h-index: 29)
J. of Cryptographic Engineering     Partially Free   (Followers: 5, SJR: 0.989, h-index: 11)
J. of Cryptology     Hybrid Journal   (Followers: 2, SJR: 1.443, h-index: 55)
J. of Cultural Economics     Hybrid Journal   (Followers: 4, SJR: 0.539, h-index: 29)
J. of Database Marketing & Customer Strategy Management     Hybrid Journal   (Followers: 8, SJR: 0.149, h-index: 8)
J. of Derivatives & Hedge Funds     Hybrid Journal   (Followers: 9, SJR: 0.114, h-index: 5)
J. of Developmental and Physical Disabilities     Hybrid Journal   (Followers: 8, SJR: 0.574, h-index: 29)
J. of Digital Imaging     Hybrid Journal   (Followers: 10, SJR: 0.578, h-index: 35)
J. of Direct Data and Digital Marketing Practice     Hybrid Journal   (Followers: 8, SJR: 0.154, h-index: 6)
J. of Dynamical and Control Systems     Hybrid Journal   (Followers: 2, SJR: 0.4, h-index: 26)
J. of Dynamics and Differential Equations     Hybrid Journal   (SJR: 1.418, h-index: 31)
J. of Earth Science     Hybrid Journal   (Followers: 8, SJR: 0.483, h-index: 16)
J. of Earth System Science     Open Access   (Followers: 43, SJR: 0.448, h-index: 32)
J. of East Asian Linguistics     Hybrid Journal   (Followers: 5, SJR: 0.537, h-index: 20)
J. of Echocardiography     Hybrid Journal   (Followers: 4, SJR: 0.22, h-index: 3)
J. of Economic Growth     Hybrid Journal   (Followers: 28, SJR: 3.273, h-index: 63)
J. of Economic Interaction and Coordination     Hybrid Journal   (SJR: 0.263, h-index: 12)
J. of Economics     Hybrid Journal   (Followers: 17, SJR: 0.418, h-index: 23)
J. of Economics and Finance     Hybrid Journal   (Followers: 6, SJR: 0.272, h-index: 19)
J. of Educational Change     Hybrid Journal   (Followers: 7, SJR: 0.961, h-index: 21)
J. of Elasticity     Hybrid Journal   (Followers: 6, SJR: 0.851, h-index: 45)
J. of Electroceramics     Hybrid Journal   (SJR: 0.577, h-index: 57)
J. of Electronic Materials     Hybrid Journal   (Followers: 4, SJR: 0.609, h-index: 75)
J. of Electronic Testing     Hybrid Journal   (Followers: 2, SJR: 0.372, h-index: 27)
J. of Electronics (China)     Hybrid Journal   (Followers: 4, SJR: 0.112, h-index: 9)
J. of Elementary Science Education     Hybrid Journal   (Followers: 8)
J. of Engineering Mathematics     Hybrid Journal   (SJR: 0.347, h-index: 37)
J. of Engineering Physics and Thermophysics     Hybrid Journal   (Followers: 1, SJR: 0.288, h-index: 11)
J. of Engineering Research     Open Access   (Followers: 1, SJR: 0.145, h-index: 5)
J. of Engineering Thermophysics     Hybrid Journal   (Followers: 2, SJR: 0.763, h-index: 9)
J. of Environmental Studies and Sciences     Partially Free   (Followers: 2)
J. of Ethology     Hybrid Journal   (Followers: 2, SJR: 0.609, h-index: 25)
J. of Evolution Equations     Hybrid Journal   (SJR: 0.826, h-index: 26)
J. of Evolutionary Biochemistry and Physiology     Hybrid Journal   (SJR: 0.145, h-index: 11)
J. of Evolutionary Economics     Hybrid Journal   (Followers: 8, SJR: 0.492, h-index: 52)
J. of Experimental and Theoretical Physics     Hybrid Journal   (Followers: 3, SJR: 0.458, h-index: 39)
J. of Experimental Criminology     Hybrid Journal   (Followers: 43, SJR: 1.445, h-index: 28)
J. of Failure Analysis and Prevention     Hybrid Journal   (Followers: 5, SJR: 0.261, h-index: 15)
J. of Family and Economic Issues     Hybrid Journal   (Followers: 6, SJR: 0.396, h-index: 32)
J. of Family Violence     Hybrid Journal   (Followers: 35, SJR: 0.639, h-index: 56)
J. of Financial Services Marketing     Hybrid Journal   (Followers: 3, SJR: 0.273, h-index: 10)
J. of Financial Services Research     Hybrid Journal   (Followers: 22, SJR: 0.572, h-index: 36)
J. of Fixed Point Theory and Applications     Hybrid Journal   (SJR: 0.644, h-index: 13)
J. of Fluorescence     Hybrid Journal   (Followers: 3, SJR: 0.465, h-index: 56)
J. of Food Measurement and Characterization     Hybrid Journal   (SJR: 0.307, h-index: 4)
J. of Food Science and Technology     Hybrid Journal   (Followers: 6, SJR: 0.441, h-index: 29)
J. of Forest Research     Hybrid Journal   (Followers: 3, SJR: 0.495, h-index: 27)
J. of Forestry Research     Hybrid Journal   (Followers: 6, SJR: 0.304, h-index: 14)
J. of Fourier Analysis and Applications     Hybrid Journal   (Followers: 1, SJR: 1.18, h-index: 42)
J. of Friction and Wear     Hybrid Journal   (Followers: 7, SJR: 0.373, h-index: 7)
J. of Fusion Energy     Hybrid Journal   (Followers: 3, SJR: 0.387, h-index: 19)
J. of Gambling Studies     Hybrid Journal   (Followers: 6, SJR: 1.171, h-index: 57)
J. of Gastroenterology     Hybrid Journal   (Followers: 11, SJR: 1.651, h-index: 88)
J. of Gastrointestinal Cancer     Hybrid Journal   (Followers: 3, SJR: 0.304, h-index: 39)
J. of Gastrointestinal Surgery     Hybrid Journal   (Followers: 6, SJR: 1.64, h-index: 99)
J. of General Internal Medicine     Hybrid Journal   (Followers: 16, SJR: 1.804, h-index: 134)
J. of General Plant Pathology     Hybrid Journal   (SJR: 0.554, h-index: 22)
J. of Genetic Counseling     Hybrid Journal   (Followers: 5, SJR: 0.902, h-index: 39)
J. of Genetics     Open Access   (Followers: 4, SJR: 0.458, h-index: 28)
J. of Geodesy     Hybrid Journal   (Followers: 8, SJR: 2.173, h-index: 56)
J. of Geographical Sciences     Hybrid Journal   (Followers: 1, SJR: 0.8, h-index: 23)
J. of Geographical Systems     Hybrid Journal   (Followers: 4, SJR: 0.822, h-index: 39)
J. of Geometric Analysis     Hybrid Journal   (SJR: 1.491, h-index: 27)
J. of Geometry     Hybrid Journal   (Followers: 1, SJR: 0.272, h-index: 15)
J. of Global Optimization     Hybrid Journal   (Followers: 4, SJR: 0.992, h-index: 60)
J. of Global Policy and Governance     Hybrid Journal   (Followers: 9)
J. of Grid Computing     Hybrid Journal   (SJR: 1.414, h-index: 37)
J. of Hand and Microsurgery     Hybrid Journal   (Followers: 1)
J. of Happiness Studies     Hybrid Journal   (Followers: 21, SJR: 0.881, h-index: 39)
J. of Hematopathology     Hybrid Journal   (Followers: 4, SJR: 0.2, h-index: 13)
J. of Heuristics     Hybrid Journal   (Followers: 5, SJR: 1.308, h-index: 50)
J. of High Energy Physics     Hybrid Journal   (Followers: 19, SJR: 1.052, h-index: 153)
J. of Homotopy and Related Structures     Hybrid Journal   (SJR: 0.232, h-index: 2)
J. of Housing and the Built Environment     Hybrid Journal   (Followers: 7, SJR: 0.648, h-index: 28)
J. of Huazhong University of Science and Technology [Medical Sciences]     Hybrid Journal   (SJR: 0.344, h-index: 19)
J. of Ichthyology     Hybrid Journal   (Followers: 3, SJR: 0.304, h-index: 10)
J. of Immigrant and Minority Health     Hybrid Journal   (Followers: 10, SJR: 0.759, h-index: 37)
J. of Inclusion Phenomena and Macrocyclic Chemistry     Hybrid Journal   (Followers: 1, SJR: 0.331, h-index: 46)
J. of Indian Philosophy     Hybrid Journal   (Followers: 12, SJR: 0.127, h-index: 12)
J. of Indian Prosthodontic Society     Open Access   (Followers: 1, SJR: 0.164, h-index: 7)
J. of Industrial Microbiology and Biotechnology     Hybrid Journal   (Followers: 14, SJR: 0.966, h-index: 80)
J. of Industry, Competition and Trade     Hybrid Journal   (Followers: 8, SJR: 0.327, h-index: 15)
J. of Infection and Chemotherapy     Hybrid Journal   (Followers: 1, SJR: 0.673, h-index: 46)
J. of Information Technology     Hybrid Journal   (Followers: 52, SJR: 1.474, h-index: 55)
J. of Information Technology Teaching Cases     Hybrid Journal   (Followers: 8)
J. of Infrared, Millimeter and Terahertz Waves     Hybrid Journal   (Followers: 2, SJR: 1.25, h-index: 36)
J. of Inherited Metabolic Disease     Hybrid Journal   (Followers: 2, SJR: 1.389, h-index: 77)
J. of Inorganic and Organometallic Polymers and Materials     Partially Free   (Followers: 8, SJR: 0.338, h-index: 33)
J. of Insect Behavior     Hybrid Journal   (Followers: 9, SJR: 0.569, h-index: 39)
J. of Insect Conservation     Hybrid Journal   (Followers: 10, SJR: 0.872, h-index: 43)
J. of Intelligent and Robotic Systems     Hybrid Journal   (Followers: 2, SJR: 0.629, h-index: 43)
J. of Intelligent Information Systems     Hybrid Journal   (Followers: 1, SJR: 0.691, h-index: 43)
J. of Intelligent Manufacturing     Hybrid Journal   (Followers: 3, SJR: 1.397, h-index: 54)
J. of Interventional Cardiac Electrophysiology     Hybrid Journal   (SJR: 0.93, h-index: 43)
J. of Intl. Business Studies     Hybrid Journal   (Followers: 28, SJR: 4.208, h-index: 130)
J. of Intl. Entrepreneurship     Hybrid Journal   (Followers: 9, SJR: 0.549, h-index: 23)
J. of Intl. Migration and Integration / Revue de l integration et de la migration internationale     Hybrid Journal   (Followers: 12, SJR: 0.308, h-index: 13)
J. of Intl. Relations and Development     Hybrid Journal   (Followers: 20, SJR: 0.793, h-index: 22)
J. of Labor Research     Hybrid Journal   (Followers: 17, SJR: 0.394, h-index: 27)
J. of Logic, Language and Information     Hybrid Journal   (Followers: 7, SJR: 0.288, h-index: 25)
J. of Low Temperature Physics     Hybrid Journal   (Followers: 3, SJR: 0.531, h-index: 52)
J. of Machinery Manufacture and Reliability     Hybrid Journal   (Followers: 2, SJR: 0.203, h-index: 7)
J. of Mammalian Evolution     Hybrid Journal   (Followers: 5, SJR: 1.134, h-index: 37)
J. of Mammary Gland Biology and Neoplasia     Hybrid Journal   (Followers: 2, SJR: 2.252, h-index: 83)
J. of Management and Governance     Hybrid Journal   (Followers: 12, SJR: 0.805, h-index: 33)
J. of Management Control     Hybrid Journal   (Followers: 5, SJR: 0.605, h-index: 6)
J. of Marine Science and Application     Hybrid Journal   (Followers: 3, SJR: 0.439, h-index: 11)
J. of Marine Science and Technology     Hybrid Journal   (Followers: 3, SJR: 0.235, h-index: 19)
J. of Maritime Archaeology     Hybrid Journal   (Followers: 21, SJR: 0.228, h-index: 8)
J. of Market-Focused Management     Hybrid Journal   (Followers: 2)
J. of Marketing Analytics     Hybrid Journal   (Followers: 3)
J. of Material Cycles and Waste Management     Hybrid Journal   (Followers: 3, SJR: 0.449, h-index: 22)
J. of Materials Engineering and Performance     Hybrid Journal   (Followers: 22, SJR: 0.544, h-index: 40)
J. of Materials Science     Hybrid Journal   (Followers: 20, SJR: 0.836, h-index: 123)
J. of Materials Science : Materials in Electronics     Hybrid Journal   (Followers: 5)
J. of Materials Science : Materials in Medicine     Hybrid Journal   (Followers: 5)
J. of Mathematical Biology     Hybrid Journal   (Followers: 12, SJR: 1.011, h-index: 71)
J. of Mathematical Chemistry     Hybrid Journal   (Followers: 5, SJR: 0.497, h-index: 45)
J. of Mathematical Fluid Mechanics     Hybrid Journal   (Followers: 6, SJR: 1.22, h-index: 22)
J. of Mathematical Imaging and Vision     Hybrid Journal   (Followers: 4, SJR: 0.901, h-index: 53)
J. of Mathematical Modelling and Algorithms     Hybrid Journal   (Followers: 2, SJR: 0.414, h-index: 23)
J. of Mathematical Sciences     Hybrid Journal   (SJR: 0.272, h-index: 23)
J. of Mathematics Teacher Education     Hybrid Journal   (Followers: 14, SJR: 1.062, h-index: 20)
J. of Maxillofacial and Oral Surgery     Hybrid Journal   (Followers: 2)
J. of Mechanical Science and Technology     Hybrid Journal   (Followers: 6, SJR: 0.589, h-index: 26)
J. of Medical and Biological Engineering     Hybrid Journal   (Followers: 1, SJR: 0.387, h-index: 18)
J. of Medical Humanities     Hybrid Journal   (Followers: 22, SJR: 0.299, h-index: 18)
J. of Medical Systems     Hybrid Journal   (Followers: 1, SJR: 0.717, h-index: 44)
J. of Medical Toxicology     Hybrid Journal   (Followers: 4, SJR: 0.874, h-index: 28)
J. of Medical Ultrasonics     Hybrid Journal   (Followers: 2, SJR: 0.18, h-index: 13)
J. of Medicine and the Person     Hybrid Journal  
J. of Membrane Biology     Hybrid Journal   (Followers: 2, SJR: 0.738, h-index: 82)
J. of Micro-Bio Robotics     Hybrid Journal   (SJR: 0.28, h-index: 3)
J. of Microbiology     Hybrid Journal   (Followers: 7, SJR: 0.741, h-index: 43)
J. of Mining Science     Hybrid Journal   (Followers: 5, SJR: 0.317, h-index: 16)
J. of Molecular Evolution     Hybrid Journal   (Followers: 9, SJR: 0.952, h-index: 108)
J. of Molecular Histology     Hybrid Journal   (Followers: 2, SJR: 0.755, h-index: 48)
J. of Molecular Medicine     Hybrid Journal   (Followers: 15, SJR: 2.165, h-index: 113)
J. of Molecular Modeling     Hybrid Journal   (Followers: 4, SJR: 0.466, h-index: 50)
J. of Molecular Neuroscience     Partially Free   (Followers: 11, SJR: 0.988, h-index: 69)
J. of Mountain Science     Hybrid Journal   (Followers: 4, SJR: 0.418, h-index: 15)
J. of Muscle Research and Cell Motility     Hybrid Journal   (Followers: 1, SJR: 1.264, h-index: 55)
J. of Nanoparticle Research     Hybrid Journal   (Followers: 3, SJR: 0.583, h-index: 84)
J. of Natural Medicines     Hybrid Journal   (SJR: 0.602, h-index: 28)
J. of Near-Death Studies     Hybrid Journal   (Followers: 2)
J. of Nephrology     Hybrid Journal   (Followers: 5, SJR: 0.689, h-index: 55)
J. of Network and Systems Management     Hybrid Journal   (SJR: 0.466, h-index: 26)
J. of Neural Transmission     Hybrid Journal   (Followers: 2, SJR: 1.034, h-index: 86)
J. of Neuro-Oncology     Hybrid Journal   (Followers: 4, SJR: 1.274, h-index: 90)
J. of Neuroimmune Pharmacology     Hybrid Journal   (Followers: 1, SJR: 1.662, h-index: 45)
J. of Neurology     Hybrid Journal   (Followers: 14, SJR: 1.429, h-index: 105)
J. of NeuroVirology     Hybrid Journal   (Followers: 1, SJR: 0.979, h-index: 69)
J. of Nondestructive Evaluation     Hybrid Journal   (Followers: 9, SJR: 0.863, h-index: 27)
J. of Nonlinear Science     Hybrid Journal   (Followers: 1, SJR: 1.887, h-index: 42)
J. of Nonverbal Behavior     Hybrid Journal   (Followers: 5, SJR: 0.723, h-index: 47)
J. of Nuclear Cardiology     Hybrid Journal   (SJR: 1.024, h-index: 68)
J. of Nutrition, Health and Aging     Hybrid Journal   (Followers: 20, SJR: 0.919, h-index: 60)
J. of Obstetrics and Gynecology of India     Hybrid Journal   (Followers: 6, SJR: 0.214, h-index: 6)
J. of Occupational Rehabilitation     Hybrid Journal   (Followers: 15, SJR: 0.811, h-index: 51)
J. of Ocean Engineering and Marine Energy     Hybrid Journal   (Followers: 1)
J. of Ocean University of China (English Edition)     Hybrid Journal   (Followers: 1, SJR: 0.237, h-index: 11)
J. of Oceanography     Hybrid Journal   (Followers: 10, SJR: 0.796, h-index: 52)
J. of Ocular Biology, Diseases, and Informatics     Hybrid Journal   (SJR: 0.183, h-index: 11)
J. of Optical and Fiber Communications Reports     Hybrid Journal   (Followers: 3)
J. of Optics     Hybrid Journal   (Followers: 8, SJR: 0.214, h-index: 8)
J. of Optimization Theory and Applications     Hybrid Journal   (Followers: 4, SJR: 0.898, h-index: 65)
J. of Ornithology     Hybrid Journal   (Followers: 22)
J. of Orofacial Orthopedics / Fortschritte der Kieferorthopädie     Hybrid Journal   (SJR: 0.574, h-index: 33)
J. of Orthopaedic Science     Hybrid Journal   (Followers: 6, SJR: 0.708, h-index: 48)
J. of Paleolimnology     Hybrid Journal   (Followers: 5, SJR: 0.984, h-index: 64)
J. of Parasitic Diseases     Hybrid Journal   (Followers: 2, SJR: 0.298, h-index: 9)
J. of Pediatric Neuropsychology     Hybrid Journal   (Followers: 3)
J. of Pest Science     Hybrid Journal   (Followers: 2, SJR: 1.341, h-index: 28)
J. of Pharmaceutical Health Care and Sciences     Open Access  
J. of Pharmaceutical Innovation     Hybrid Journal   (Followers: 8, SJR: 0.524, h-index: 17)
J. of Pharmaceutical Investigation     Hybrid Journal   (Followers: 1, SJR: 0.331, h-index: 6)
J. of Pharmacokinetics and Pharmacodynamics     Hybrid Journal   (Followers: 18, SJR: 0.708, h-index: 46)
J. of Phase Equilibria and Diffusion     Hybrid Journal   (Followers: 18, SJR: 0.433, h-index: 36)
J. of Philosophical Logic     Hybrid Journal   (Followers: 8, SJR: 0.704, h-index: 26)
J. of Physiology and Biochemistry     Hybrid Journal   (Followers: 3, SJR: 0.87, h-index: 33)

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Journal Cover European Surgery
  [SJR: 0.171]   [H-I: 15]   [5 followers]  Follow
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1682-4016 - ISSN (Online) 1682-8631
   Published by Springer-Verlag Homepage  [2335 journals]
  • The preliminary role of circulating tumor cells obtained from the hepatic
           or portal veins in patients with hepatobiliary–pancreatic cancer
    • Authors: Naokazu Chiba; Yuta Abe; Yosuke Ozawa; Kosuke Hikita; Masaaki Okihara; Toru Sano; Koichi Tomita; Kiminori Takano; Shigeyuki Kawachi
      Pages: 5 - 8
      Abstract: Summary Background Metastases, which result from circulating tumor cells (CTC) that have detached from the primary cancer and survived in distant organs, cause the majority of cancer deaths. The present study aimed to assess the prognostic relevance of CTC in patients with hepatobiliary–pancreatic cancer. Methods A total of 30 consenting patients were enrolled. Pre-resection blood samples were obtained from the hepatic or portal veins of patients, respectively. CTCs were analyzed using the CellSearch system and isolated using antibodies against the epithelial cell adhesion molecule and cytokeratin. Patients were separated into 2 groups based on their CTC counts. The CTC-positive group included patients with baseline CTC counts >10/7.5 ml. Results Of the 30 patients, 12 (40 %) were considered CTC positive. CTC-positive patients had a shorter 1‑year progression-free survival (PFS) than CTC-negative patients (71.1 % vs. 36.4 %, p = 0.0324); however, no difference was observed in the 3‑year overall survival (47.1 % vs. 45.5 %, p = 0.7576). In particular, CTC-positive pancreatic carcinoma patients had a shorter 1‑year PFS (22.2 % vs. 0.0 % for CTC-negative, p = 0.0018). Conclusions Elevated CTC from hepatic or portal veins might predict a shorter PFS in patients with hepatobiliary–pancreatic cancer, particularly those with pancreatic carcinoma.
      PubDate: 2017-02-01
      DOI: 10.1007/s10353-016-0439-8
      Issue No: Vol. 49, No. 1 (2017)
  • Small endoscopic sphincterotomy combined with endoscopic papillary
           large-balloon dilation in the treatment of patients with large bile duct
    • Authors: X. Chu; H. Zhang; R. Qu; G. Huang; C. Guo; F. Wang; M. Cheng
      Pages: 9 - 16
      Abstract: Summary Background To compare the effectiveness and safety of the combination of endoscopic papillary large-balloon dilation (EPLBD) and small endoscopic sphincterotomy (SEST) with either EST or EPLBD alone in the treatment of large bile duct stones. Methods A total of 127 patients with large bile duct stones were enrolled and randomly divided into four treatment groups (the SEST + EPLBD group, the EPLBD + SEST group, the EST group, and the EPLBD group) in a 1:1:1:1 ratio. Evaluation variables included the success rates of complete stone removal, complete stone removal without the use of endoscopic mechanical lithotripsy (EML), and complete stone removal in one session, as well as the occurrence of short- and long-term postoperative complications. Results The overall rate of stone clearance was quite similar among the four treatment groups. There was no significant difference in the rate of complete stone removal without the use of EML among these groups. However, the combination treatment groups required relatively fewer sessions than did the EPLBD group. The incidence rates of short- and long-term complications were relatively lower in the two combination groups than in the EST and EPLBD groups. Conclusions A combination of SEST and EPLBD appears to be safe and effective for patients with large bile duct stones. This combination may have potential safety advantages in comparison with EST or EPLBD alone.
      PubDate: 2017-02-01
      DOI: 10.1007/s10353-016-0388-2
      Issue No: Vol. 49, No. 1 (2017)
  • Application of modified small bladder patch-to-bladder double-layer
           sutures to improve renal transplantation in mice
    • Authors: Chen Wenwei; Yang Yirong; Katarzyna M. Stevens; Michal Heger; Xia Peng
      Pages: 17 - 22
      Abstract: Summary Background This study aimed to introduce an improved surgical procedure to reduce the incidence of urinary tract complications after renal transplantation in mice using a modified bladder patch-to-bladder anastomosis technique. Methods Renal isotransplantation was performed in 28 male C57BL/6 mice. The urinary tract was reconstructed with a ureteral anastomosis between the donor’s small bladder patch and the recipient’s bladder. The bladder patch was secured through a cystotomy in the recipient’s bladder mucosa and seromuscular layers, which were sutured in a double-layer manner. The food intake and survival of mice were recorded for 100 days in addition to monitoring appearance, weight, and symptoms of pain. On post-transplantation day 7, the native kidney in the recipients was removed and the transplanted kidney assessed visually. Urine leakage from the transplanted graft was monitored by assessing the degree of ascites. Results The success rate of renal transplantation was 82 % (23 of 28 cases). Arterial thrombosis at the site of anastomosis occurred in 3 cases (11 %) and hemorrhagic shock in 2 cases (7 %). The mean ± SD time of the operation in recipients was 81 ± 5 min. No complications were noted in the successfully transplanted animals. Conclusions The modified procedure of a small bladder patch-to-bladder with double-layer suturing minimizes complications after renal transplantation in mice while requiring the same operating time as other approaches such as ureter to bladder anastomosis, which are associated with more complications.
      PubDate: 2017-02-01
      DOI: 10.1007/s10353-016-0391-7
      Issue No: Vol. 49, No. 1 (2017)
  • Contribution of gallbladder polyp surgery to treatment
    • Authors: Tolga Aliyazicioglu; Senol Carilli; Ali Emre; Aziz Kaya; Dursun Bugra; Orhan Bilge; Tunc Yalti; Burcak Kabaoglu; Aydin Alper
      Pages: 23 - 26
      Abstract: Summary Background Surgery is the preferred treatment for gallbladder polyps, not only for relieving the symptoms but also for eliminating the potential risk of malignancy. In our study, we investigated whether patients who had undergone surgery truly had a surgical indication and beyond question required laparoscopic cholecystectomy due to malignancy. Materials and methods 185 patients who were prediagnosed with gallbladder polyps were operated in VKV American Hospital, Istanbul between January 2004 and July 2015. Retrospective data of all patients included patients’ age, gender, symptoms, preoperative ultrasonography, pathology reports, radiologic findings regarding the number and size of the polyps, and postoperative follow-up. Results 140 out of 185 patients were symptomatic before surgery. 85 patients (60.7 %) reported that their symptoms persisted after they had undergone surgery. 20 (14.3 %) of the patients with postoperatively persisting symptoms had no polyps in their pathologic examination. Only 35 out of 140 patients (25 %) reported relief of symptoms following surgery. Postoperative pathologic investigation revealed adenocarcinoma in only 1 patient and adenomatous polyps in 2 patients. Conclusion Postoperative pathologic investigations reveal only a very small percentage of premalignant and malignant polyps among patients who have undergone laparoscopic cholecystectomy. This finding clearly points out that we require new methods to differentiate cholesterol polyps from adenomatous polyps. Furthermore, the surgical indication criteria for patients with gall bladder polyps should be updated to prevent futile operations and morbidity.
      PubDate: 2017-02-01
      DOI: 10.1007/s10353-016-0422-4
      Issue No: Vol. 49, No. 1 (2017)
  • A novel glue device for fixation of mesh and peritoneal closure during
           laparoscopic inguinal hernia repair: short- and medium-term results
    • Authors: Bernhard Dauser; Alexander Szyszkowitz; Gerald Seitinger; René H. Fortelny; Friedrich Herbst
      Pages: 27 - 31
      Abstract: Summary Background Mesh fixation during transabdominal preperitoneal (TAPP) hernia repair should be done using nonpenetrating fixation devices in order to reduce acute and chronic pain. Beside fibrin sealant, N‑butyl cyanoacrylate (NBCA) can be applied. However, there are limited data using NBCA exclusively for fixation of mesh and closure of peritoneum following TAPP repair. We therefore studied a novel laparoscopic fixation device (LiquiBand®Fix8™ by Advanced Medical Solutions, Plymouth, UK) addressing these issues. Methods A prospective study was performed in two (different tertiary referral) centres in Austria, including patients undergoing TAPP repair between January and May 2015. The aforementioned device was used for fixation of mesh at predefined reference points (rectus muscle, pubic bone, triangle of doom, triangle of pain) and entire closure of peritoneum whenever possible. Results In a total of 34 (4 female) patients, 40 inguinal hernias were repaired using the TAPP approach. Fixation of mesh at four predefined reference points was successful using a single liquid anchor in 88.1 % (141/160). Thorough closure of peritoneum using NBCA was possible in 36 cases (90.0 %). Twice, additional suturing was done as the device clogged during this step of procedure. Finally, in another 2 patients, the attending surgeon declined using glue at all, as the sigmoid colon attached exerted too much traction. No device-related complication was recorded during 1‑year follow-up. Conclusion Nonpenetrating fixation of mesh during TAPP repair using this novel device is highly effective. In addition, closure of peritoneum using exclusively NBCA is safe and feasible according to our experience
      PubDate: 2017-02-01
      DOI: 10.1007/s10353-016-0450-0
      Issue No: Vol. 49, No. 1 (2017)
  • Impact of ultrasound examination shortly after kidney transplantation
    • Authors: Christoph Schwarz; Jakob Mühlbacher; Georg A. Böhmig; Marin Purtic; Eleonore Pablik; Lukas Unger; Ivan Kristo; Thomas Soliman; Gabriela A. Berlakovich
      Abstract: Summary Background Ultrasound is routinely performed at our transplant unit within the first 48 h of kidney transplantation (KTX). The objective of this study was to evaluate the association of ultrasound results and, in particular, elevated resistance indices (RIs) with the occurrence of surgical complications and allograft outcomes. Methods The study included all kidney allograft recipients undergoing transplantation at our center between January 2010 and December 2011 (N = 329). Ultrasound examination was performed on 315 recipients (95.7%). Results Delayed graft function was more common in subjects with a high RI (≥0.7) than in patients with an RI < 0.7 (47.2 vs. 28.2%; p = 0.032). A lack of arterial signal was detected in eight patients (2.5%), of whom five had a vascular complication that required surgical therapy. In 12 patients (3.8%), RI was 1 without any other signs of vascular impairment. Even though such values can be a sign of venous thrombosis, no case was observed in any of these patients. Conclusions The results of our study suggest that ultrasound evaluation of the transplanted kidney shortly after transplantation is a valuable tool not only for detecting vascular complications but also as a predictor of graft outcome regarding delayed graft function.
      PubDate: 2017-02-16
      DOI: 10.1007/s10353-017-0467-z
  • Caudate resection for primary and metastatic liver tumors
    • Authors: Georgios C. Sotiropoulos; Petros Charalampoudis; Paraskevas Stamopoulos; Nikolaos Machairas; Eleftherios D. Spartalis; Stylianos Kykalos; Gregory Kouraklis
      Abstract: Summary Background Surgical procedures involving the caudate lobe of the liver are characterized as the most demanding operations in liver surgery. Methods Liver resections including the caudate lobe performed at our institution by one senior hepatobiliary surgeon in a 2-year period were reviewed for the purposes of this study. Indications comprised primary and metastatic liver lesions. Results In a total of 60 hepatectomies, 12 patients underwent caudate lobe resection (20%). This was either isolated resection of segment I (n = 3) or combined with right, left, extended left hepatectomy or atypical resections in one, three, one, and four instances, respectively. Vascular resections/reconstructions were necessary in six cases (three cases each for portal vein and vena cava). All but one patient were directly extubated. Median hospital stay was 10.5 days. Surgical complications were classified as Dindo–Clavien grades I (n = 4), II (n = 4), IIIa (n = 1), IIIb (n = 2), and IV (n = 1). Conclusion Surgery for tumors located in the caudate lobe is feasible and can be safely performed by experienced teams.
      PubDate: 2017-02-15
      DOI: 10.1007/s10353-017-0466-0
  • Laparoscopic appendectomy using only two 5 mm trocars
    • Authors: Hugo Bonatti
      Abstract: Summary Background Laparoscopic appendectomy is now the standard and most surgeons use two 5 mm and one 10–12 mm port; the latter placed into the umbilicus. Various attempts have been made to reduce the number and sizes of ports for this procedure. Case report A 22-year-old male with acute right lower quadrant pain came to our emergency room. His white blood count (WBC) was 15000 l/ml and on CT scan signs of acute appendicitis were found. He was taken to the operating room. His abdomen was accessed with a Verres in the left upper quadrant (LUQ) and once pneumoperitoneum was established a 5 mm trocar was placed under visual control into the left lower quadrant (LLQ). A phlegmonous appendix was found attached to the right abdominal wall. The Verres needle was exchanged for another 5 mm trocar. A Maryland grasper was used to bluntly create a window between appendix base and mesoappendix. The appendiceal artery was dissected out and secured with a 5 mm clip and the mesoappendix was cut off the appendix. Two endoloops were lassoed around the appendix and tied at the appendix base and the specimen was amputated between the ties. The appendix was pulled with the distal tie towards the LUQ port, which was removed. The appendix base was grabbed with a Kelly clamp and the specimen was pulled through the port site. Pneumoperitoneum was released and the LLQ port removed and the skin closed. The patient was discharged after 2 h and had a completely uneventful recovery. Conclusion In selected cases with favorable anatomy, laparoscopic appendectomy with two 5 mm ports may be possible. Miniaturizing this procedure while carefully weighing patient safety and costs should be a goal for laparoscopic appendectomy.
      PubDate: 2017-02-10
      DOI: 10.1007/s10353-017-0465-1
  • Fecal occult blood test/fecal carcinoembriogenic antigen dual rapid test
           as a useful tool for colorectal cancer screening
    • Authors: Maru Kim; Hyung-Jin Kim; In Kyu Lee; Seong-Taek Oh; Kyungja Han
      Abstract: Summary Background There are several screening tools for colorectal cancer (CRC). Most are limited in their application. The fecal occult blood test (FOBT) is a first-step screen for CRC that is limited by low sensitivity. This study aimed to prove the efficacy of combined FOBT and fecal carcinoembryogenic antigen (fCEA) as a CRC screening test. Methods Stool samples were collected preoperatively from 166 CRC patients expected to undergo elective surgery and from normal control patients. A fecal CEA/FOBT dual kit was created and the results from the use of this dual kit were compared against other clinicopathologic parameters. Results FOBT was positive in 103 of the 166 (62.0%) CRC patients and fCEA was positive in 114 (68.7%) patients, showing a statistically positive relationship. Among 63 FOBT negative patients, 29 (17%) cases were CEA positive. Thus, the CEA/FOBT dual test could detect CRC in 79.5% of the patients (132/166). The sensitivity and specificity of the dual FOBT/CEA test was 79.5% and 97.9%, respectively. Conclusions The FOBT/CEA dual test has increased sensitivity compared to the FOBT test and may have merit as a screening device for colorectal cancer. Population-based studies are required to confirm this potential.
      PubDate: 2017-02-03
      DOI: 10.1007/s10353-017-0464-2
  • Laparoscopic removal of an accessory spleen for recurrent idiopathic
           thrombocytopenic purpura 5 years after laparoscopic splenectomy using
           perioperative eltrombopag conditioning
    • Authors: Hugo Bonatti; Daniel Medina; Natalia Kubicki; Stephen Kavic
      Abstract: Summary Background Treatment of idiopathic thrombocytopenic purpura (ITP) refractory to medical management consists of splenectomy with a high success rate. Recurrent ITP may be due to re-growth of a missed accessory spleen. Methods The clinical course of a 59-year-old female who had undergone laparoscopic splenectomy for ITP refractory to medical management 5 years ago developed a sudden drop in her platelet count to as low as 1 K/ml and she developed purpura. Results On liver/spleen scan and CT scan a 5 × 5 cm mass containing splenic tissue was found close to the tail of the pancreas. Eltrombopag (Promacta®) was used to stabilize her platelet count. During laparoscopy dense adhesion of the omentum to the abdominal wall and stomach from her previous splenectomy had to be divided. The colon was identified, the lesser sack opened through the gastrocolic ligament and the splenic flexure was taken down. The stomach was lifted anteriorly and medially to expose the tail of the pancreas and superior and dorsal to the pancreas at the previous splenic hilum the mass was identified and carefully dissected off the pancreas, kidney and adrenal gland. An endo GI with a white load was used to divide the vascular pedicle, which originated from a side branch of the splenic artery and splenic vein at the tail of the pancreas and secured with an endoloop. The accessory spleen was placed into an endobag, cut in small pieces and removed through the 10–12 mm port. The patient recovered well from the procedure without any complications and her platelet count normalized within a few weeks. Discussion Re-growth of splenic tissue causing recurrent ITP is a rare condition but should be considered. Laparoscopic removal of accessory spleens can be safely done. Newly developed agents are helpful in the management of ITP patients.
      PubDate: 2017-01-18
      DOI: 10.1007/s10353-016-0461-x
  • Erratum zu: Bariatrische Eingriffe in der Therapie des Diabetes mellitus
           Typ II
    • Authors: Stephan Kriwanek; Nada Loibner; Philipp Patri; Mathias Hofmann
      PubDate: 2017-01-16
      DOI: 10.1007/s10353-016-0463-8
  • Preoperative nutritional counseling versus standard care prior to
           bariatric surgery
    • Authors: Stavros A. Antoniou; Anastasia Anastasiadou; George A. Antoniou; Frank-Alexander Granderath; Antonios Kafatos
      Abstract: Summary Background Little is known about the effect of preoperative nutritional counseling on operative outcomes of bariatric surgery. Aim To identify and evaluate the effect of nutritional counseling on perioperative morbidity and postoperative weight loss. Methods The database of Medline was queried in May 2016. Randomized controlled trials comparing nutritional counseling of any form with standard care and providing data on perioperative morbidity or weight loss were considered. Pooled risk ratio (RR) or mean difference with 95% confidence intervals (CI) were computed. Results Three randomized controlled trials were identified. The RR for postoperative complications was 0.80 (95% CI 0.22–2.86) and the mean weight loss was −11.62 kg (95% CI 0.72 to −23.96). There was high evidence of heterogeneity among reports. No data on operative morbidity were available. Conclusion Current data are not adequately robust to support preoperative nutritional intervention as an effective modality to prevent perioperative morbidity and to achieve more optimal postoperative weight control. In the absence of opposing evidence, nutritional counseling prior to surgery may be conventionally recommended.
      PubDate: 2017-01-13
      DOI: 10.1007/s10353-016-0459-4
  • Prediction of 30-day mortality after emergency surgery for colorectal
    • Authors: Tomoyuki Abe; Ken Shirabe; Norifumi Harimoto; Tomonobu Gion; Takashi Nagaie; Kiyoshi Kajiyama
      Abstract: Summary Background We aimed to validate the use of two physiologic and operative severity scoring systems for the enumeration of mortality and morbidity (Portsmouth, P‑POSSUM; colorectal, Cr-POSSUM) for the prediction of 30-day mortality after emergency surgery for colorectal perforation. Methods We retrospectively reviewed the records of a consecutive series of patients who had undergone emergency surgery for colorectal perforation between April 2001 and July 2007 at our hospital. The study population was stratified into two groups according to whether the patients survived longer than 30 days postoperatively or died within 30 days of surgery. Two scoring systems (P-POSSUM and Cr-POSSUM) were used to predict mortality risk in each patient based on patient- and disease-related risk factors. The prediction capability for each scoring system was calculated based on the area under the receiver-operator characteristic curve. Results The 30-day mortality rate was 12% (8/66 patients). Significant differences between patients who died within 30 days postoperatively and those who survived were noted regarding age, but not regarding comorbidities or preoperative laboratory data. Patient-related factors, rather than surgical factors, had a significantly greater influence on postoperative outcomes (p = 0.025), but the operative severity score did not contribute significantly. The P‑POSSUM score was a significant predictor of 30-day mortality (p = 0.0075). Conclusions Our findings demonstrate that P‑POSSUM and Cr-POSSUM can both be used to predict mortality after emergency surgery for colorectal perforation. While not explicitly developed for colorectal surgery, P‑POSSUM represents a promising tool for monitoring outcomes after emergency surgery for colorectal perforation.
      PubDate: 2017-01-13
      DOI: 10.1007/s10353-016-0460-y
  • Doing the job in surgery 2017: you and your theories
    • Authors: F. M. Riegler
      PubDate: 2017-01-13
      DOI: 10.1007/s10353-016-0462-9
  • Viability of five different pre- and intraoperative imaging methods for
           autologous breast reconstruction
    • Authors: K. F. Schrögendorfer; S. Nickl; M. Keck; D. B. Lumenta; C. Loewe; M. Gschwandtner; W. Haslik; J. Nedomansky
      Pages: 326 - 333
      Abstract: Summary Background Autologous breast reconstruction is an integral part in the treatment of breast cancer. While computed tomography angiography (CTA) is an established preoperative diagnostic tool for microsurgeons, no study has so far evaluated and compared five different imaging methods and their value for the reconstructive team. In order to determine the feasibility of each of the tools for routine or specialized diagnostic application, the methods’ efficiency and informative value were analyzed. Methods We retrospectively analyzed imaging data of 41 patients used for perforator location and assessment for regional perfusion and vessel patency in patients undergoing autologous breast reconstruction with deep inferior epigastric perforator flap (DIEP), transverse rectus abdominis muscle flap (TRAM), or transverse myocutaneous gracilis flap (TMG). Five different imaging techniques were used: hand held Doppler (HHD), CT angiography (CTA), macroscopic indocyanine green (ICG) video angiography, microscope-integrated ICG video angiography, and laser Doppler imaging (LDI). Results CTA proved to be the best tool for preoperative determination of the highly variable anatomy of the abdominal region, whereas HHD showed the same information on perforator localization with some false-positive results. Intraoperative HHD was an excellent tool for dissection and vessel patency judgment. Microscope-integrated ICG was an excellent tool to document the patency of microanastomoses. In our series, macroscopic perfusion measurement with ICG or LDI was only justified in special situations, where information on perfusion of abdominal or mastectomy flaps was required. LDI did not add any additional information. Conclusion Preoperative assessment should be performed by CTA with verification of the perforator location by HHD. Intraoperative HHD and microscope-integrated ICG contribute most toward the evaluation of vessel patency. ICG and LDI should only be used for special indications.
      PubDate: 2016-12-01
      DOI: 10.1007/s10353-016-0449-6
      Issue No: Vol. 48, No. 6 (2016)
  • The importance of diagnostic awareness of groove pancreatitis
    • Authors: Erkan Oymaci; Serdar Akdoğan; Nurettin Kahramansoy; Ahmet Deniz Uçar; Savaş Yakan; Ayvaz Ulaş Urgancı; Özgür Esen Sipahi; Nazif Erkan; Mehmet Yildirim
      Pages: 357 - 360
      Abstract: Summary Background Groove pancreatitis is a form of focal chronic pancreatitis in the pancreatic tissue between the duodenal wall and the intrapancreatic portion of the common bile duct. Groove pancreatitis, paraduodenal pancreatitis, and duodenal dystrophy are regarded as synonyms by some authors whereas others use the term duodenal dystrophy. We aimed to review this rare entity and discuss its clinical features, diagnosis, and therapy. Methods We present a series of three cases of groove pancreatitis diagnosed at a tertiary medical center with a detailed review of the current medical literature. Results All patient were treated with conservative medical therapy, which consists of spasmolytic and analgesic therapy as well as antibiotic and enteral nutrition during hospitalization. Endoscopic drainage with endoscopic retrograde cholangiopancreatography (ERCP) was performed for two patients. No complications were observed after the ERCP procedure. Conclusion Groove pancreatitis can simulate, mask, or coexist with pancreatic carcinoma and it can be difficult to differentiate from adenocarcinoma. Clinical, radiological, and histological features may be helpful in making the differential diagnosis and should be keep in mind in the differential diagnosis of pancreatic head masses or duodenal wall stenosis.
      PubDate: 2016-12-01
      DOI: 10.1007/s10353-016-0424-2
      Issue No: Vol. 48, No. 6 (2016)
  • Cystic tumors of the pancreas
    • Authors: Thomas Sautner
      Pages: 376 - 377
      PubDate: 2016-12-01
      DOI: 10.1007/s10353-016-0448-7
      Issue No: Vol. 48, No. 6 (2016)
  • Surgery of acute severe ulcerative colitis. Subtotal colectomy: when and
           how to do it'
    • Authors: Rosario Fornaro; Elisa Caratto; Michela Caratto; Camilla Sticchi; Alexander Salerno; Rita Bianchi; Stefano Scabini; Marco Casaccia
      Abstract: Summary Purpose The aim of this review is to focus attention on the role of surgery in the management of acute ulcerative colitis (UC). UC is a chronic inflammatory disease of the mucosa of the large intestine. Methods We have examined the data from the literature of the past 20 years and we have analyzed the role of emergency surgery. A medical literature search was conducted using Medline, Embase, Ovid Journals, and Science Direct. Results Acute severe colitis (ASC) occurs in 12–25% of patients affected by UC. Patients with ASC should be managed by a multidisciplinary team. Aggressive medical or surgical treatment is undertaken with the final aim of reducing mortality. Intravenous corticosteroids are the mainstay of therapy. Medical rescue therapy based on cyclosporine or infliximab should be considered if there is no response to corticosteroids after 3 days. In the event that there has been no response to medical rescue therapy after 4–7 days, the patient must undergo urgent colectomy surgery. Prolonged observation is counterproductive as over time it increases the risk of toxic megacolon and of perforation burdened with a very high mortality rate. Conclusions The best possible treatment is represented by subtotal colectomy with ileostomy and preservation of a long rectal stump. Emergency colectomy is characterized by high morbidity and low mortality rates.
      PubDate: 2016-12-22
      DOI: 10.1007/s10353-016-0458-5
  • Oxidative stress and angiogenesis in primary hyperparathyroidism
    • Authors: Mariusz Deska; Ewa Romuk; Oliwia Anna Segiet; Grzegorz Buła; Witold Truchanowski; Dominika Stolecka; Ewa Birkner; Jacek Gawrychowski
      Abstract: Summary Background The inappropriate elevation of parathormone (PTH), which regulates the process of angiogenesis in parathyroid tissue, causes the changes of activity of enzymes responsible for the removal of free radicals. Parathyroidectomy (PTX) in patients with primary hyperparathyroidism (PHPT) lowers the level of PTH and leads to the reduction of risk of cardiovascular and all-cause mortality by normalization of the antioxidant status. Therefore, the aims of the study were to assess the activity of antioxidant enzymes and free radical reaction products in patients after parathyroidectomy, and to evaluate the correlation between the systemic oxidative stress and angiogenic parameters. Materials and methods Patients with PHPT treated surgically were enrolled into the study. Total antioxidant capacity (TAC), total oxidative status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), ceruloplasmin (CER), lipid hydroperoxides (LHP) and malondialdehyde (MDA) were measured before and after parathyroidectomy. The immunohistological expression of angiogenic factors in parathyroid specimens was assessed by the BrightVision method from ImmunoLogic using murine monoclonal anti-human: anti-VEGF, anti-CD31 and anti-CD106 antibodies. Results The significant increase of TAC, CER, reduction of TOS, MDA, SOD, especially for cytoplasmic form, and significant decrease of OSI, LHP were observed after PTX. There was no significant correlation between changes of oxidative stress markers and angiogenic parameters: VEGF, CD-31, CD-106 in parathyroid tissue. The correlation level was low and medium. Conclusions Parathyroidectomy causes down-regulation of lipid peroxidation processes and leads to reduction of oxidative stress in patients with PHPT. The decrease in the OSI is the results of down-regulation of oxidative stress in the postoperative period. The change of the antioxidant status has no impact on angiogenesis processes in parathyroid tissue.
      PubDate: 2016-12-14
      DOI: 10.1007/s10353-016-0457-6
  • Marfan syndrome presenting with abdominal aortic aneurysm during pregnancy
    • Authors: J. Pasternak; M. Kaćanski; N. Budakov
      Abstract: Summary Methods We report a case of successfully performed Caesarean section followed by reconstruction of the abdominal aorta in a patient with Marfan syndrome. Results A 35-year-old woman at 37 weeks’ gestation in her second pregnancy was referred with abdominal aortic aneurysm. On admission she was asymptomatic, haemodynamically stable, and without clinical and radiological signs of rupture. Magnetic resonance imaging confirmed that the infrarenal aortic aneurysm continued to the right common iliac artery. Following preoperative assessment, it was decided to finalize gestation and reconstruct the aorta in a one-stage procedure. After a median xyphopubic laparotomy, Mizgav–Ladach Caesarean section and Pomeroy tubal sterilization were performed, followed by aneurysmectomy and aorto-bilateral iliac artery bypass. The postoperative course was uneventful. Both mother and child were doing well at follow-up 3, 9 and 12 months after the intervention. Conclusion To the best of our knowledge, this is the first case of true abdominal aortic aneurysm repair and Caesarean section as a one-stage procedure.
      PubDate: 2016-12-08
      DOI: 10.1007/s10353-016-0456-7
  • Perioperative fluid management
    • Authors: Martin W. Dünser; Arthur Kwizera
      PubDate: 2016-12-01
      DOI: 10.1007/s10353-016-0455-8
  • Effect of different doses of 2‑aminoethoxydiphenyl borate on intestinal
           ischemia-reperfusion injury
    • Authors: Murat Basbug; Murat Yildar; İsmail Yaman; Faruk Cavdar; Ömer Faruk Özkan; Hasan Aksit; Musa Ozgür Ozyigit; Figen Aslan; Hayrullah Derici
      Abstract: Summary Background Acute mesenteric ischemia is a life-threatening clinical entity. 2‑Aminoethoxydiphenyl borate (2-APB) is a membrane-permeable modulator of intracellular inositol triphosphate-induced calcium release. We investigated the effects of different 2‑APB doses on intestinal ischemia-reperfusion injury in an experimental rat model. Methods We divided 24 Wistar albino rats into four groups: sham, control, ischemia-reperfusion +2 mg/kg 2‑APB, and ischemia-reperfusion +4 mg/kg 2‑APB. The sham group only underwent laparotomy for 1 h 30 min. A 30-min period of mesenteric ischemia was induced in the control and two treatment groups, followed by 1 h of reperfusion. Before the laparotomy, 2 mg/kg and 4 mg/kg 2‑APB was administered i.v. in the treatments groups, and blood samples were collected after reperfusion. Serum levels of malondialdehyde, superoxide dismutase, glutathione, total antioxidant capacity, tumor necrosis factor (TNF)-α, and interleukin-6 were analyzed. Intestinal tissues were taken for histopathological, DNA fragmentation, and terminal deoxynucleotidyl transferase dUTP nick end labeling analyses to determine the proportion of apoptotic cells. Results 2-APB reduced serum malondialdehyde, TNF-α, and interleukin-6 levels. However, superoxide dismutase and total antioxidant capacity levels increased significantly in the 4‑mg/kg 2‑APB group (p < 0.05). The intestinal histopathological injury scores were significantly higher in the control group; these injuries were prevented in the 4‑mg/kg 2‑APB dose group. DNA damage after ischemia-perfusion decreased significantly in the 4‑mg/kg 2‑APB group compared with the control group. Conclusion 2-APB decreases oxidative stress and cell injury. Administering 4 mg/kg 2‑APB prevented ischemia-perfusion injury by diminishing histological damage.
      PubDate: 2016-11-16
      DOI: 10.1007/s10353-016-0452-y
  • Erratum to: Surgical approach is superior to palliative treatment in
           oligometastatic lung cancer
    • Authors: Till Ploenes; Alberto Lopez-Pastorini; Erich Stoelben
      PubDate: 2016-11-10
      DOI: 10.1007/s10353-016-0445-x
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