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Publisher: Springer-Verlag   (Total: 2335 journals)

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Showing 1201 - 1400 of 2335 Journals sorted alphabetically
J. of Community Health     Hybrid Journal   (Followers: 8, SJR: 0.921, h-index: 44)
J. of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology     Hybrid Journal   (Followers: 7, SJR: 1.087, h-index: 74)
J. of Comparative Physiology B : Biochemical, Systemic, and Environmental Physiology     Hybrid Journal   (Followers: 4, SJR: 1.126, h-index: 59)
J. of Compassionate Health Care     Open Access   (Followers: 2)
J. of Computational Analysis and Applications     Hybrid Journal   (SJR: 0.291, h-index: 19)
J. of Computational Electronics     Hybrid Journal   (Followers: 4, SJR: 0.511, h-index: 20)
J. of Computational Neuroscience     Hybrid Journal   (Followers: 24, SJR: 1.068, h-index: 60)
J. of Computer and Systems Sciences Intl.     Hybrid Journal   (SJR: 0.27, h-index: 13)
J. of Computer Science and Technology     Open Access   (Followers: 5, SJR: 0.437, h-index: 31)
J. of Computer Virology and Hacking Techniques     Hybrid Journal   (Followers: 6, SJR: 0.151, h-index: 2)
J. of Computer-Aided Molecular Design     Hybrid Journal   (Followers: 3, SJR: 0.995, h-index: 78)
J. of Computers in Education     Hybrid Journal   (Followers: 8)
J. of Computing in Higher Education     Hybrid Journal   (Followers: 13, SJR: 0.363, h-index: 21)
J. of Consumer Policy     Hybrid Journal   (Followers: 7, SJR: 0.704, h-index: 30)
J. of Contemporary Mathematical Analysis     Hybrid Journal   (SJR: 0.237, h-index: 5)
J. of Contemporary Physics (Armenian Academy of Sciences)     Hybrid Journal   (Followers: 11, SJR: 0.197, h-index: 6)
J. of Contemporary Psychotherapy     Hybrid Journal   (Followers: 5, SJR: 0.397, h-index: 23)
J. of Control Theory and Applications     Hybrid Journal   (Followers: 2, SJR: 0.359, h-index: 19)
J. of Control, Automation and Electrical Systems     Hybrid Journal   (Followers: 9, SJR: 0.231, h-index: 9)
J. of Crop Science and Biotechnology     Hybrid Journal   (Followers: 7)
J. of Cross-Cultural Gerontology     Hybrid Journal   (Followers: 5, SJR: 0.631, h-index: 29)
J. of Cryptographic Engineering     Partially Free   (Followers: 5, SJR: 0.989, h-index: 11)
J. of Cryptology     Hybrid Journal   (Followers: 2, SJR: 1.443, h-index: 55)
J. of Cultural Economics     Hybrid Journal   (Followers: 4, SJR: 0.539, h-index: 29)
J. of Database Marketing & Customer Strategy Management     Hybrid Journal   (Followers: 8, SJR: 0.149, h-index: 8)
J. of Derivatives & Hedge Funds     Hybrid Journal   (Followers: 9, SJR: 0.114, h-index: 5)
J. of Developmental and Physical Disabilities     Hybrid Journal   (Followers: 8, SJR: 0.574, h-index: 29)
J. of Digital Imaging     Hybrid Journal   (Followers: 10, SJR: 0.578, h-index: 35)
J. of Direct Data and Digital Marketing Practice     Hybrid Journal   (Followers: 8, SJR: 0.154, h-index: 6)
J. of Dynamical and Control Systems     Hybrid Journal   (Followers: 2, SJR: 0.4, h-index: 26)
J. of Dynamics and Differential Equations     Hybrid Journal   (SJR: 1.418, h-index: 31)
J. of Earth Science     Hybrid Journal   (Followers: 8, SJR: 0.483, h-index: 16)
J. of Earth System Science     Open Access   (Followers: 43, SJR: 0.448, h-index: 32)
J. of East Asian Linguistics     Hybrid Journal   (Followers: 5, SJR: 0.537, h-index: 20)
J. of Echocardiography     Hybrid Journal   (Followers: 4, SJR: 0.22, h-index: 3)
J. of Economic Growth     Hybrid Journal   (Followers: 27, SJR: 3.273, h-index: 63)
J. of Economic Interaction and Coordination     Hybrid Journal   (SJR: 0.263, h-index: 12)
J. of Economics     Hybrid Journal   (Followers: 17, SJR: 0.418, h-index: 23)
J. of Economics and Finance     Hybrid Journal   (Followers: 6, SJR: 0.272, h-index: 19)
J. of Educational Change     Hybrid Journal   (Followers: 7, SJR: 0.961, h-index: 21)
J. of Elasticity     Hybrid Journal   (Followers: 6, SJR: 0.851, h-index: 45)
J. of Electroceramics     Hybrid Journal   (SJR: 0.577, h-index: 57)
J. of Electronic Materials     Hybrid Journal   (Followers: 4, SJR: 0.609, h-index: 75)
J. of Electronic Testing     Hybrid Journal   (Followers: 2, SJR: 0.372, h-index: 27)
J. of Electronics (China)     Hybrid Journal   (Followers: 4, SJR: 0.112, h-index: 9)
J. of Elementary Science Education     Hybrid Journal   (Followers: 9)
J. of Engineering Mathematics     Hybrid Journal   (SJR: 0.347, h-index: 37)
J. of Engineering Physics and Thermophysics     Hybrid Journal   (Followers: 1, SJR: 0.288, h-index: 11)
J. of Engineering Research     Open Access   (Followers: 1, SJR: 0.145, h-index: 5)
J. of Engineering Thermophysics     Hybrid Journal   (Followers: 2, SJR: 0.763, h-index: 9)
J. of Environmental Studies and Sciences     Partially Free   (Followers: 2)
J. of Ethology     Hybrid Journal   (Followers: 2, SJR: 0.609, h-index: 25)
J. of Evolution Equations     Hybrid Journal   (SJR: 0.826, h-index: 26)
J. of Evolutionary Biochemistry and Physiology     Hybrid Journal   (SJR: 0.145, h-index: 11)
J. of Evolutionary Economics     Hybrid Journal   (Followers: 8, SJR: 0.492, h-index: 52)
J. of Experimental and Theoretical Physics     Hybrid Journal   (Followers: 3, SJR: 0.458, h-index: 39)
J. of Experimental Criminology     Hybrid Journal   (Followers: 44, SJR: 1.445, h-index: 28)
J. of Failure Analysis and Prevention     Hybrid Journal   (Followers: 5, SJR: 0.261, h-index: 15)
J. of Family and Economic Issues     Hybrid Journal   (Followers: 6, SJR: 0.396, h-index: 32)
J. of Family Violence     Hybrid Journal   (Followers: 36, SJR: 0.639, h-index: 56)
J. of Financial Services Marketing     Hybrid Journal   (Followers: 3, SJR: 0.273, h-index: 10)
J. of Financial Services Research     Hybrid Journal   (Followers: 22, SJR: 0.572, h-index: 36)
J. of Fixed Point Theory and Applications     Hybrid Journal   (SJR: 0.644, h-index: 13)
J. of Fluorescence     Hybrid Journal   (Followers: 3, SJR: 0.465, h-index: 56)
J. of Food Measurement and Characterization     Hybrid Journal   (SJR: 0.307, h-index: 4)
J. of Food Science and Technology     Hybrid Journal   (Followers: 6, SJR: 0.441, h-index: 29)
J. of Forest Research     Hybrid Journal   (Followers: 3, SJR: 0.495, h-index: 27)
J. of Forestry Research     Hybrid Journal   (Followers: 6, SJR: 0.304, h-index: 14)
J. of Fourier Analysis and Applications     Hybrid Journal   (Followers: 1, SJR: 1.18, h-index: 42)
J. of Friction and Wear     Hybrid Journal   (Followers: 7, SJR: 0.373, h-index: 7)
J. of Fusion Energy     Hybrid Journal   (Followers: 3, SJR: 0.387, h-index: 19)
J. of Gambling Studies     Hybrid Journal   (Followers: 6, SJR: 1.171, h-index: 57)
J. of Gastroenterology     Hybrid Journal   (Followers: 12, SJR: 1.651, h-index: 88)
J. of Gastrointestinal Cancer     Hybrid Journal   (Followers: 3, SJR: 0.304, h-index: 39)
J. of Gastrointestinal Surgery     Hybrid Journal   (Followers: 6, SJR: 1.64, h-index: 99)
J. of General Internal Medicine     Hybrid Journal   (Followers: 16, SJR: 1.804, h-index: 134)
J. of General Plant Pathology     Hybrid Journal   (SJR: 0.554, h-index: 22)
J. of Genetic Counseling     Hybrid Journal   (Followers: 5, SJR: 0.902, h-index: 39)
J. of Genetics     Open Access   (Followers: 4, SJR: 0.458, h-index: 28)
J. of Geodesy     Hybrid Journal   (Followers: 8, SJR: 2.173, h-index: 56)
J. of Geographical Sciences     Hybrid Journal   (Followers: 1, SJR: 0.8, h-index: 23)
J. of Geographical Systems     Hybrid Journal   (Followers: 4, SJR: 0.822, h-index: 39)
J. of Geometric Analysis     Hybrid Journal   (SJR: 1.491, h-index: 27)
J. of Geometry     Hybrid Journal   (Followers: 1, SJR: 0.272, h-index: 15)
J. of Global Optimization     Hybrid Journal   (Followers: 4, SJR: 0.992, h-index: 60)
J. of Global Policy and Governance     Hybrid Journal   (Followers: 9)
J. of Grid Computing     Hybrid Journal   (Followers: 1, SJR: 1.414, h-index: 37)
J. of Hand and Microsurgery     Hybrid Journal   (Followers: 1)
J. of Happiness Studies     Hybrid Journal   (Followers: 23, SJR: 0.881, h-index: 39)
J. of Hematopathology     Hybrid Journal   (Followers: 4, SJR: 0.2, h-index: 13)
J. of Heuristics     Hybrid Journal   (Followers: 5, SJR: 1.308, h-index: 50)
J. of High Energy Physics     Hybrid Journal   (Followers: 19, SJR: 1.052, h-index: 153)
J. of Homotopy and Related Structures     Hybrid Journal   (SJR: 0.232, h-index: 2)
J. of Housing and the Built Environment     Hybrid Journal   (Followers: 7, SJR: 0.648, h-index: 28)
J. of Huazhong University of Science and Technology [Medical Sciences]     Hybrid Journal   (SJR: 0.344, h-index: 19)
J. of Ichthyology     Hybrid Journal   (Followers: 3, SJR: 0.304, h-index: 10)
J. of Immigrant and Minority Health     Hybrid Journal   (Followers: 11, SJR: 0.759, h-index: 37)
J. of Inclusion Phenomena and Macrocyclic Chemistry     Hybrid Journal   (Followers: 1, SJR: 0.331, h-index: 46)
J. of Indian Philosophy     Hybrid Journal   (Followers: 12, SJR: 0.127, h-index: 12)
J. of Indian Prosthodontic Society     Open Access   (Followers: 1, SJR: 0.164, h-index: 7)
J. of Industrial Microbiology and Biotechnology     Hybrid Journal   (Followers: 15, SJR: 0.966, h-index: 80)
J. of Industry, Competition and Trade     Hybrid Journal   (Followers: 8, SJR: 0.327, h-index: 15)
J. of Infection and Chemotherapy     Hybrid Journal   (Followers: 1, SJR: 0.673, h-index: 46)
J. of Information Technology     Hybrid Journal   (Followers: 54, SJR: 1.474, h-index: 55)
J. of Information Technology Teaching Cases     Hybrid Journal   (Followers: 8)
J. of Infrared, Millimeter and Terahertz Waves     Hybrid Journal   (Followers: 2, SJR: 1.25, h-index: 36)
J. of Inherited Metabolic Disease     Hybrid Journal   (Followers: 2, SJR: 1.389, h-index: 77)
J. of Inorganic and Organometallic Polymers and Materials     Partially Free   (Followers: 9, SJR: 0.338, h-index: 33)
J. of Insect Behavior     Hybrid Journal   (Followers: 9, SJR: 0.569, h-index: 39)
J. of Insect Conservation     Hybrid Journal   (Followers: 10, SJR: 0.872, h-index: 43)
J. of Intelligent and Robotic Systems     Hybrid Journal   (Followers: 2, SJR: 0.629, h-index: 43)
J. of Intelligent Information Systems     Hybrid Journal   (Followers: 1, SJR: 0.691, h-index: 43)
J. of Intelligent Manufacturing     Hybrid Journal   (Followers: 3, SJR: 1.397, h-index: 54)
J. of Interventional Cardiac Electrophysiology     Hybrid Journal   (SJR: 0.93, h-index: 43)
J. of Intl. Business Studies     Hybrid Journal   (Followers: 30, SJR: 4.208, h-index: 130)
J. of Intl. Entrepreneurship     Hybrid Journal   (Followers: 9, SJR: 0.549, h-index: 23)
J. of Intl. Migration and Integration / Revue de l integration et de la migration internationale     Hybrid Journal   (Followers: 13, SJR: 0.308, h-index: 13)
J. of Intl. Relations and Development     Hybrid Journal   (Followers: 20, SJR: 0.793, h-index: 22)
J. of Labor Research     Hybrid Journal   (Followers: 17, SJR: 0.394, h-index: 27)
J. of Logic, Language and Information     Hybrid Journal   (Followers: 7, SJR: 0.288, h-index: 25)
J. of Low Temperature Physics     Hybrid Journal   (Followers: 3, SJR: 0.531, h-index: 52)
J. of Machinery Manufacture and Reliability     Hybrid Journal   (Followers: 2, SJR: 0.203, h-index: 7)
J. of Mammalian Evolution     Hybrid Journal   (Followers: 5, SJR: 1.134, h-index: 37)
J. of Mammary Gland Biology and Neoplasia     Hybrid Journal   (Followers: 2, SJR: 2.252, h-index: 83)
J. of Management and Governance     Hybrid Journal   (Followers: 13, SJR: 0.805, h-index: 33)
J. of Management Control     Hybrid Journal   (Followers: 4, SJR: 0.605, h-index: 6)
J. of Marine Science and Application     Hybrid Journal   (Followers: 3, SJR: 0.439, h-index: 11)
J. of Marine Science and Technology     Hybrid Journal   (Followers: 3, SJR: 0.235, h-index: 19)
J. of Maritime Archaeology     Hybrid Journal   (Followers: 21, SJR: 0.228, h-index: 8)
J. of Market-Focused Management     Hybrid Journal   (Followers: 2)
J. of Marketing Analytics     Hybrid Journal   (Followers: 4)
J. of Material Cycles and Waste Management     Hybrid Journal   (Followers: 3, SJR: 0.449, h-index: 22)
J. of Materials Engineering and Performance     Hybrid Journal   (Followers: 22, SJR: 0.544, h-index: 40)
J. of Materials Science     Hybrid Journal   (Followers: 20, SJR: 0.836, h-index: 123)
J. of Materials Science : Materials in Electronics     Hybrid Journal   (Followers: 5)
J. of Materials Science : Materials in Medicine     Hybrid Journal   (Followers: 5)
J. of Mathematical Biology     Hybrid Journal   (Followers: 12, SJR: 1.011, h-index: 71)
J. of Mathematical Chemistry     Hybrid Journal   (Followers: 5, SJR: 0.497, h-index: 45)
J. of Mathematical Fluid Mechanics     Hybrid Journal   (Followers: 6, SJR: 1.22, h-index: 22)
J. of Mathematical Imaging and Vision     Hybrid Journal   (Followers: 4, SJR: 0.901, h-index: 53)
J. of Mathematical Modelling and Algorithms     Hybrid Journal   (Followers: 2, SJR: 0.414, h-index: 23)
J. of Mathematical Sciences     Hybrid Journal   (SJR: 0.272, h-index: 23)
J. of Mathematics Teacher Education     Hybrid Journal   (Followers: 14, SJR: 1.062, h-index: 20)
J. of Maxillofacial and Oral Surgery     Hybrid Journal   (Followers: 2)
J. of Mechanical Science and Technology     Hybrid Journal   (Followers: 6, SJR: 0.589, h-index: 26)
J. of Medical and Biological Engineering     Hybrid Journal   (Followers: 1, SJR: 0.387, h-index: 18)
J. of Medical Humanities     Hybrid Journal   (Followers: 22, SJR: 0.299, h-index: 18)
J. of Medical Systems     Hybrid Journal   (Followers: 1, SJR: 0.717, h-index: 44)
J. of Medical Toxicology     Hybrid Journal   (Followers: 4, SJR: 0.874, h-index: 28)
J. of Medical Ultrasonics     Hybrid Journal   (Followers: 2, SJR: 0.18, h-index: 13)
J. of Medicine and the Person     Hybrid Journal  
J. of Membrane Biology     Hybrid Journal   (Followers: 2, SJR: 0.738, h-index: 82)
J. of Micro-Bio Robotics     Hybrid Journal   (SJR: 0.28, h-index: 3)
J. of Microbiology     Hybrid Journal   (Followers: 8, SJR: 0.741, h-index: 43)
J. of Mining Science     Hybrid Journal   (Followers: 5, SJR: 0.317, h-index: 16)
J. of Molecular Evolution     Hybrid Journal   (Followers: 9, SJR: 0.952, h-index: 108)
J. of Molecular Histology     Hybrid Journal   (Followers: 2, SJR: 0.755, h-index: 48)
J. of Molecular Medicine     Hybrid Journal   (Followers: 15, SJR: 2.165, h-index: 113)
J. of Molecular Modeling     Hybrid Journal   (Followers: 4, SJR: 0.466, h-index: 50)
J. of Molecular Neuroscience     Partially Free   (Followers: 11, SJR: 0.988, h-index: 69)
J. of Mountain Science     Hybrid Journal   (Followers: 4, SJR: 0.418, h-index: 15)
J. of Muscle Research and Cell Motility     Hybrid Journal   (Followers: 1, SJR: 1.264, h-index: 55)
J. of Nanoparticle Research     Hybrid Journal   (Followers: 3, SJR: 0.583, h-index: 84)
J. of Natural Medicines     Hybrid Journal   (SJR: 0.602, h-index: 28)
J. of Near-Death Studies     Hybrid Journal   (Followers: 2)
J. of Nephrology     Hybrid Journal   (Followers: 5, SJR: 0.689, h-index: 55)
J. of Network and Systems Management     Hybrid Journal   (SJR: 0.466, h-index: 26)
J. of Neural Transmission     Hybrid Journal   (Followers: 2, SJR: 1.034, h-index: 86)
J. of Neuro-Oncology     Hybrid Journal   (Followers: 3, SJR: 1.274, h-index: 90)
J. of Neuroimmune Pharmacology     Hybrid Journal   (Followers: 1, SJR: 1.662, h-index: 45)
J. of Neurology     Hybrid Journal   (Followers: 15, SJR: 1.429, h-index: 105)
J. of NeuroVirology     Hybrid Journal   (Followers: 1, SJR: 0.979, h-index: 69)
J. of Nondestructive Evaluation     Hybrid Journal   (Followers: 9, SJR: 0.863, h-index: 27)
J. of Nonlinear Science     Hybrid Journal   (Followers: 1, SJR: 1.887, h-index: 42)
J. of Nonverbal Behavior     Hybrid Journal   (Followers: 5, SJR: 0.723, h-index: 47)
J. of Nuclear Cardiology     Hybrid Journal   (SJR: 1.024, h-index: 68)
J. of Nutrition, Health and Aging     Hybrid Journal   (Followers: 20, SJR: 0.919, h-index: 60)
J. of Obstetrics and Gynecology of India     Hybrid Journal   (Followers: 6, SJR: 0.214, h-index: 6)
J. of Occupational Rehabilitation     Hybrid Journal   (Followers: 15, SJR: 0.811, h-index: 51)
J. of Ocean Engineering and Marine Energy     Hybrid Journal   (Followers: 1)
J. of Ocean University of China (English Edition)     Hybrid Journal   (Followers: 1, SJR: 0.237, h-index: 11)
J. of Oceanography     Hybrid Journal   (Followers: 10, SJR: 0.796, h-index: 52)
J. of Ocular Biology, Diseases, and Informatics     Hybrid Journal   (SJR: 0.183, h-index: 11)
J. of Optical and Fiber Communications Reports     Hybrid Journal   (Followers: 3)
J. of Optics     Hybrid Journal   (Followers: 8, SJR: 0.214, h-index: 8)
J. of Optimization Theory and Applications     Hybrid Journal   (Followers: 4, SJR: 0.898, h-index: 65)
J. of Ornithology     Hybrid Journal   (Followers: 22)
J. of Orofacial Orthopedics / Fortschritte der Kieferorthopädie     Hybrid Journal   (SJR: 0.574, h-index: 33)
J. of Orthopaedic Science     Hybrid Journal   (Followers: 6, SJR: 0.708, h-index: 48)
J. of Paleolimnology     Hybrid Journal   (Followers: 5, SJR: 0.984, h-index: 64)
J. of Parasitic Diseases     Hybrid Journal   (Followers: 2, SJR: 0.298, h-index: 9)
J. of Pediatric Neuropsychology     Hybrid Journal   (Followers: 3)
J. of Pest Science     Hybrid Journal   (Followers: 2, SJR: 1.341, h-index: 28)
J. of Pharmaceutical Health Care and Sciences     Open Access  
J. of Pharmaceutical Innovation     Hybrid Journal   (Followers: 8, SJR: 0.524, h-index: 17)
J. of Pharmaceutical Investigation     Hybrid Journal   (Followers: 1, SJR: 0.331, h-index: 6)
J. of Pharmacokinetics and Pharmacodynamics     Hybrid Journal   (Followers: 18, SJR: 0.708, h-index: 46)
J. of Phase Equilibria and Diffusion     Hybrid Journal   (Followers: 18, SJR: 0.433, h-index: 36)
J. of Philosophical Logic     Hybrid Journal   (Followers: 8, SJR: 0.704, h-index: 26)
J. of Physiology and Biochemistry     Hybrid Journal   (Followers: 3, SJR: 0.87, h-index: 33)

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Journal Cover European Surgery
  [SJR: 0.171]   [H-I: 15]   [6 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1682-4016 - ISSN (Online) 1682-8631
   Published by Springer-Verlag Homepage  [2335 journals]
  • The preliminary role of circulating tumor cells obtained from the hepatic
           or portal veins in patients with hepatobiliary–pancreatic cancer
    • Authors: Naokazu Chiba; Yuta Abe; Yosuke Ozawa; Kosuke Hikita; Masaaki Okihara; Toru Sano; Koichi Tomita; Kiminori Takano; Shigeyuki Kawachi
      Pages: 5 - 8
      Abstract: Summary Background Metastases, which result from circulating tumor cells (CTC) that have detached from the primary cancer and survived in distant organs, cause the majority of cancer deaths. The present study aimed to assess the prognostic relevance of CTC in patients with hepatobiliary–pancreatic cancer. Methods A total of 30 consenting patients were enrolled. Pre-resection blood samples were obtained from the hepatic or portal veins of patients, respectively. CTCs were analyzed using the CellSearch system and isolated using antibodies against the epithelial cell adhesion molecule and cytokeratin. Patients were separated into 2 groups based on their CTC counts. The CTC-positive group included patients with baseline CTC counts >10/7.5 ml. Results Of the 30 patients, 12 (40 %) were considered CTC positive. CTC-positive patients had a shorter 1‑year progression-free survival (PFS) than CTC-negative patients (71.1 % vs. 36.4 %, p = 0.0324); however, no difference was observed in the 3‑year overall survival (47.1 % vs. 45.5 %, p = 0.7576). In particular, CTC-positive pancreatic carcinoma patients had a shorter 1‑year PFS (22.2 % vs. 0.0 % for CTC-negative, p = 0.0018). Conclusions Elevated CTC from hepatic or portal veins might predict a shorter PFS in patients with hepatobiliary–pancreatic cancer, particularly those with pancreatic carcinoma.
      PubDate: 2017-02-01
      DOI: 10.1007/s10353-016-0439-8
      Issue No: Vol. 49, No. 1 (2017)
       
  • Small endoscopic sphincterotomy combined with endoscopic papillary
           large-balloon dilation in the treatment of patients with large bile duct
           stones
    • Authors: X. Chu; H. Zhang; R. Qu; G. Huang; C. Guo; F. Wang; M. Cheng
      Pages: 9 - 16
      Abstract: Summary Background To compare the effectiveness and safety of the combination of endoscopic papillary large-balloon dilation (EPLBD) and small endoscopic sphincterotomy (SEST) with either EST or EPLBD alone in the treatment of large bile duct stones. Methods A total of 127 patients with large bile duct stones were enrolled and randomly divided into four treatment groups (the SEST + EPLBD group, the EPLBD + SEST group, the EST group, and the EPLBD group) in a 1:1:1:1 ratio. Evaluation variables included the success rates of complete stone removal, complete stone removal without the use of endoscopic mechanical lithotripsy (EML), and complete stone removal in one session, as well as the occurrence of short- and long-term postoperative complications. Results The overall rate of stone clearance was quite similar among the four treatment groups. There was no significant difference in the rate of complete stone removal without the use of EML among these groups. However, the combination treatment groups required relatively fewer sessions than did the EPLBD group. The incidence rates of short- and long-term complications were relatively lower in the two combination groups than in the EST and EPLBD groups. Conclusions A combination of SEST and EPLBD appears to be safe and effective for patients with large bile duct stones. This combination may have potential safety advantages in comparison with EST or EPLBD alone.
      PubDate: 2017-02-01
      DOI: 10.1007/s10353-016-0388-2
      Issue No: Vol. 49, No. 1 (2017)
       
  • Application of modified small bladder patch-to-bladder double-layer
           sutures to improve renal transplantation in mice
    • Authors: Chen Wenwei; Yang Yirong; Katarzyna M. Stevens; Michal Heger; Xia Peng
      Pages: 17 - 22
      Abstract: Summary Background This study aimed to introduce an improved surgical procedure to reduce the incidence of urinary tract complications after renal transplantation in mice using a modified bladder patch-to-bladder anastomosis technique. Methods Renal isotransplantation was performed in 28 male C57BL/6 mice. The urinary tract was reconstructed with a ureteral anastomosis between the donor’s small bladder patch and the recipient’s bladder. The bladder patch was secured through a cystotomy in the recipient’s bladder mucosa and seromuscular layers, which were sutured in a double-layer manner. The food intake and survival of mice were recorded for 100 days in addition to monitoring appearance, weight, and symptoms of pain. On post-transplantation day 7, the native kidney in the recipients was removed and the transplanted kidney assessed visually. Urine leakage from the transplanted graft was monitored by assessing the degree of ascites. Results The success rate of renal transplantation was 82 % (23 of 28 cases). Arterial thrombosis at the site of anastomosis occurred in 3 cases (11 %) and hemorrhagic shock in 2 cases (7 %). The mean ± SD time of the operation in recipients was 81 ± 5 min. No complications were noted in the successfully transplanted animals. Conclusions The modified procedure of a small bladder patch-to-bladder with double-layer suturing minimizes complications after renal transplantation in mice while requiring the same operating time as other approaches such as ureter to bladder anastomosis, which are associated with more complications.
      PubDate: 2017-02-01
      DOI: 10.1007/s10353-016-0391-7
      Issue No: Vol. 49, No. 1 (2017)
       
  • Contribution of gallbladder polyp surgery to treatment
    • Authors: Tolga Aliyazicioglu; Senol Carilli; Ali Emre; Aziz Kaya; Dursun Bugra; Orhan Bilge; Tunc Yalti; Burcak Kabaoglu; Aydin Alper
      Pages: 23 - 26
      Abstract: Summary Background Surgery is the preferred treatment for gallbladder polyps, not only for relieving the symptoms but also for eliminating the potential risk of malignancy. In our study, we investigated whether patients who had undergone surgery truly had a surgical indication and beyond question required laparoscopic cholecystectomy due to malignancy. Materials and methods 185 patients who were prediagnosed with gallbladder polyps were operated in VKV American Hospital, Istanbul between January 2004 and July 2015. Retrospective data of all patients included patients’ age, gender, symptoms, preoperative ultrasonography, pathology reports, radiologic findings regarding the number and size of the polyps, and postoperative follow-up. Results 140 out of 185 patients were symptomatic before surgery. 85 patients (60.7 %) reported that their symptoms persisted after they had undergone surgery. 20 (14.3 %) of the patients with postoperatively persisting symptoms had no polyps in their pathologic examination. Only 35 out of 140 patients (25 %) reported relief of symptoms following surgery. Postoperative pathologic investigation revealed adenocarcinoma in only 1 patient and adenomatous polyps in 2 patients. Conclusion Postoperative pathologic investigations reveal only a very small percentage of premalignant and malignant polyps among patients who have undergone laparoscopic cholecystectomy. This finding clearly points out that we require new methods to differentiate cholesterol polyps from adenomatous polyps. Furthermore, the surgical indication criteria for patients with gall bladder polyps should be updated to prevent futile operations and morbidity.
      PubDate: 2017-02-01
      DOI: 10.1007/s10353-016-0422-4
      Issue No: Vol. 49, No. 1 (2017)
       
  • A novel glue device for fixation of mesh and peritoneal closure during
           laparoscopic inguinal hernia repair: short- and medium-term results
    • Authors: Bernhard Dauser; Alexander Szyszkowitz; Gerald Seitinger; René H. Fortelny; Friedrich Herbst
      Pages: 27 - 31
      Abstract: Summary Background Mesh fixation during transabdominal preperitoneal (TAPP) hernia repair should be done using nonpenetrating fixation devices in order to reduce acute and chronic pain. Beside fibrin sealant, N‑butyl cyanoacrylate (NBCA) can be applied. However, there are limited data using NBCA exclusively for fixation of mesh and closure of peritoneum following TAPP repair. We therefore studied a novel laparoscopic fixation device (LiquiBand®Fix8™ by Advanced Medical Solutions, Plymouth, UK) addressing these issues. Methods A prospective study was performed in two (different tertiary referral) centres in Austria, including patients undergoing TAPP repair between January and May 2015. The aforementioned device was used for fixation of mesh at predefined reference points (rectus muscle, pubic bone, triangle of doom, triangle of pain) and entire closure of peritoneum whenever possible. Results In a total of 34 (4 female) patients, 40 inguinal hernias were repaired using the TAPP approach. Fixation of mesh at four predefined reference points was successful using a single liquid anchor in 88.1 % (141/160). Thorough closure of peritoneum using NBCA was possible in 36 cases (90.0 %). Twice, additional suturing was done as the device clogged during this step of procedure. Finally, in another 2 patients, the attending surgeon declined using glue at all, as the sigmoid colon attached exerted too much traction. No device-related complication was recorded during 1‑year follow-up. Conclusion Nonpenetrating fixation of mesh during TAPP repair using this novel device is highly effective. In addition, closure of peritoneum using exclusively NBCA is safe and feasible according to our experience
      PubDate: 2017-02-01
      DOI: 10.1007/s10353-016-0450-0
      Issue No: Vol. 49, No. 1 (2017)
       
  • Behind and beyond surgery
    • Authors: F. M. Riegler
      PubDate: 2017-03-15
      DOI: 10.1007/s10353-017-0474-0
       
  • Endoscopic-assisted linea alba reconstruction
    • Authors: Ferdinand Köckerling; Marinos Damianos Botsinis; Christine Rohde; Wolfgang Reinpold; Christine Schug-Pass
      Abstract: Summary Background Patients with symptomatic umbilical, trocar, and/or epigastric hernias and concomitant rectus abdominis diastasis represent a growing clinical problem. The optimal management of this complex hernia situation is the subject of debate in the literature. This paper reports the early results of an innovative surgical technique aimed at managing this hernia situation. Methods Endoscopic-assisted linea alba reconstruction (ELAR) with mesh augmentation is a surgical technique long known in the literature for its good outcome for incisional hernia repair (myofascial release, overlapping herniorrhaphy, Gibson’s operation, shoelace repair, anterior rectus sheath repair, dynamic patch plasty) via a small access route. The early results for 140 patients are presented here. Results Two patients (1.4%) developed postoperative complications requiring redo surgery. These were two cases of diffuse secondary bleeding without an identifiable bleeding source, in one patient with liver cirrhosis and portal hypertension and in another patient receiving treatment with platelet aggregation inhibitors. All other complications were successively managed with conservative treatment. After 1 year, two of 30 patients reported occasional pain, including pain at rest in one patient. Conclusion The ELAR technique with mesh augmentation is an innovative, minimally invasive surgical procedure for treatment of patients with a complex abdominal wall hernia comprising symptomatic umbilical, trocar, and/or epigastric hernias with concomitant rectus abdominis diastasis.
      PubDate: 2017-03-10
      DOI: 10.1007/s10353-017-0473-1
       
  • Endoscopic mini/less open sublay operation for treatment of primary and
           secondary ventral hernias of the abdominal wall
    • Authors: R. Bittner; J. Schwarz
      Abstract: Summary Background Primary and secondary ventral hernias of the abdominal wall are very common conditions; however, the ideal operative treatment has not been found yet. Methods In the traditional open sublay technique, a large trauma to the abdominal wall must be accepted, which carries a high risk of infection, while the laparoscopic intraperitoneal onlay mesh (IPOM) technique is burdened with the need for special and expensive meshes and fixation devices as well. Moreover, the IPOM technique carries a significant risk of bowel injury. In order to avoid the disadvantages of these techniques, we developed an endoscopic technique (endoscopic mini/less open sublay; EMILOS) that allows for complete dissection of the retromuscular space for placement of a huge mesh to reinforce the whole anterior abdominal wall, while performing a 5-cm skin incision only. Results From June 2015 to January 2017, a total of 50 patients were operated on using the MILOS concept, nine patients underwent the original MILOS technique, and 41 patients had the EMILOS operation. The operative steps of this novel endoscopic variation, the EMILOS procedure, are described in detail. The average skin incision was 5.1 cm (3–8), and mean operative time was 160 min (90–255). In 38 patients the size of the mesh was 30 × 20 cm, in two patients 30 × 16 cm, and in one patient 15 × 15 cm. The average hospital stay was 3.2 days. The median pain score (VAS) under physical stress (e. g., climbing stairs) was 2.7. Conclusion The first results of the EMILOS operation are promising. The technique is standardized, reproducible, cost-effective, and allows one to place a large mesh into the retromuscular position, while avoiding severe trauma to the abdominal wall and the transabdominal route.
      PubDate: 2017-03-10
      DOI: 10.1007/s10353-017-0472-2
       
  • Mesh technologies and challenges in modern hernia surgery and abdominal
           wall repair
    • Authors: Alexander H. Petter-Puchner; Simone Gruber-Blum; Heinz Redl; Karl S. Glaser; René H. Fortelny
      Abstract: Summary Hernia surgery is a rapidly evolving field, characterized by an abundance of mesh and fixation materials. This article aims at providing an overview of the most recent and urgent developments in mesh and scaffold technologies.
      PubDate: 2017-03-10
      DOI: 10.1007/s10353-017-0470-4
       
  • What are the needs for education in hernia surgery for the future?
    • Authors: R. Lorenz; B. Stechemesser; W. Reinpold; F. Mayer; F. Köckerling; W. Schröder; R. Fortelny
      Abstract: Summary Introduction Hernia surgery has undergone rapid development in the past decades. The ever greater array of surgical techniques and materials together with the demand for individualized treatment concepts thus present a special challenge not only to qualified surgeons but also when devising education programs for trainee surgeons. To that effect, continuing education and training concepts must be reviewed and possibly new concepts formulated. This study now reports on the findings from a survey on continuing education and training in hernia surgery, while presenting and evaluating the existing concepts. Materials and Methods In 2014 the German Hernia Society (DHG) in cooperation with the Federal Association of German Surgeons (BDC) conducted a broad-based online survey among surgeons on the future of continuing education in hernia surgery. Since 2011 basic courses in hernia surgery have been in place in Germany, and since 2014 in Austria too. In the meantime, further Hernia School levels have also been introduced. We compared the learning effects identified for participants of the two Hernia compact courses in Salzburg in 2014 and 2016. Besides, special questionnaires were designed to explore new and topical issues. Results In total, 1296 surgeons in Germany took part in the BDC / DHG online survey on the future of continuing education in hernia surgery. The vast majority (more than 80%) of respondents deemed the establishment of a systematic, step-by-step and structured continuing education program to be useful or very useful. Evaluation of the basic training courses already conducted revealed that both the theoretical knowledge and practical experience of participants improved thanks to these courses. Conclusion From the perspective of surgeons there is an urgent need for a systematic, structured and step-by-step concept for continuing education hernia surgery. This should include, in addition to theoretical and practical aspects, eLearning, video tutorials, and simulation models. Since to date there is a lack of empirical data, continuous evaluation of the training courses is an important component for further development of such courses. This can markedly enhance the theoretical knowledge and practical experience of participants. Besides, systematic survey of participants helps to continuously tailor the curriculum to future needs.
      PubDate: 2017-02-28
      DOI: 10.1007/s10353-017-0469-x
       
  • Editorial
    • Authors: René H. Fortelny
      PubDate: 2017-02-27
      DOI: 10.1007/s10353-017-0468-y
       
  • Impact of ultrasound examination shortly after kidney transplantation
    • Authors: Christoph Schwarz; Jakob Mühlbacher; Georg A. Böhmig; Marin Purtic; Eleonore Pablik; Lukas Unger; Ivan Kristo; Thomas Soliman; Gabriela A. Berlakovich
      Abstract: Summary Background Ultrasound is routinely performed at our transplant unit within the first 48 h of kidney transplantation (KTX). The objective of this study was to evaluate the association of ultrasound results and, in particular, elevated resistance indices (RIs) with the occurrence of surgical complications and allograft outcomes. Methods The study included all kidney allograft recipients undergoing transplantation at our center between January 2010 and December 2011 (N = 329). Ultrasound examination was performed on 315 recipients (95.7%). Results Delayed graft function was more common in subjects with a high RI (≥0.7) than in patients with an RI < 0.7 (47.2 vs. 28.2%; p = 0.032). A lack of arterial signal was detected in eight patients (2.5%), of whom five had a vascular complication that required surgical therapy. In 12 patients (3.8%), RI was 1 without any other signs of vascular impairment. Even though such values can be a sign of venous thrombosis, no case was observed in any of these patients. Conclusions The results of our study suggest that ultrasound evaluation of the transplanted kidney shortly after transplantation is a valuable tool not only for detecting vascular complications but also as a predictor of graft outcome regarding delayed graft function.
      PubDate: 2017-02-16
      DOI: 10.1007/s10353-017-0467-z
       
  • Caudate resection for primary and metastatic liver tumors
    • Authors: Georgios C. Sotiropoulos; Petros Charalampoudis; Paraskevas Stamopoulos; Nikolaos Machairas; Eleftherios D. Spartalis; Stylianos Kykalos; Gregory Kouraklis
      Abstract: Summary Background Surgical procedures involving the caudate lobe of the liver are characterized as the most demanding operations in liver surgery. Methods Liver resections including the caudate lobe performed at our institution by one senior hepatobiliary surgeon in a 2-year period were reviewed for the purposes of this study. Indications comprised primary and metastatic liver lesions. Results In a total of 60 hepatectomies, 12 patients underwent caudate lobe resection (20%). This was either isolated resection of segment I (n = 3) or combined with right, left, extended left hepatectomy or atypical resections in one, three, one, and four instances, respectively. Vascular resections/reconstructions were necessary in six cases (three cases each for portal vein and vena cava). All but one patient were directly extubated. Median hospital stay was 10.5 days. Surgical complications were classified as Dindo–Clavien grades I (n = 4), II (n = 4), IIIa (n = 1), IIIb (n = 2), and IV (n = 1). Conclusion Surgery for tumors located in the caudate lobe is feasible and can be safely performed by experienced teams.
      PubDate: 2017-02-15
      DOI: 10.1007/s10353-017-0466-0
       
  • Laparoscopic appendectomy using only two 5 mm trocars
    • Authors: Hugo Bonatti
      Abstract: Summary Background Laparoscopic appendectomy is now the standard and most surgeons use two 5 mm and one 10–12 mm port; the latter placed into the umbilicus. Various attempts have been made to reduce the number and sizes of ports for this procedure. Case report A 22-year-old male with acute right lower quadrant pain came to our emergency room. His white blood count (WBC) was 15000 l/ml and on CT scan signs of acute appendicitis were found. He was taken to the operating room. His abdomen was accessed with a Verres in the left upper quadrant (LUQ) and once pneumoperitoneum was established a 5 mm trocar was placed under visual control into the left lower quadrant (LLQ). A phlegmonous appendix was found attached to the right abdominal wall. The Verres needle was exchanged for another 5 mm trocar. A Maryland grasper was used to bluntly create a window between appendix base and mesoappendix. The appendiceal artery was dissected out and secured with a 5 mm clip and the mesoappendix was cut off the appendix. Two endoloops were lassoed around the appendix and tied at the appendix base and the specimen was amputated between the ties. The appendix was pulled with the distal tie towards the LUQ port, which was removed. The appendix base was grabbed with a Kelly clamp and the specimen was pulled through the port site. Pneumoperitoneum was released and the LLQ port removed and the skin closed. The patient was discharged after 2 h and had a completely uneventful recovery. Conclusion In selected cases with favorable anatomy, laparoscopic appendectomy with two 5 mm ports may be possible. Miniaturizing this procedure while carefully weighing patient safety and costs should be a goal for laparoscopic appendectomy.
      PubDate: 2017-02-10
      DOI: 10.1007/s10353-017-0465-1
       
  • Fecal occult blood test/fecal carcinoembriogenic antigen dual rapid test
           as a useful tool for colorectal cancer screening
    • Authors: Maru Kim; Hyung-Jin Kim; In Kyu Lee; Seong-Taek Oh; Kyungja Han
      Abstract: Summary Background There are several screening tools for colorectal cancer (CRC). Most are limited in their application. The fecal occult blood test (FOBT) is a first-step screen for CRC that is limited by low sensitivity. This study aimed to prove the efficacy of combined FOBT and fecal carcinoembryogenic antigen (fCEA) as a CRC screening test. Methods Stool samples were collected preoperatively from 166 CRC patients expected to undergo elective surgery and from normal control patients. A fecal CEA/FOBT dual kit was created and the results from the use of this dual kit were compared against other clinicopathologic parameters. Results FOBT was positive in 103 of the 166 (62.0%) CRC patients and fCEA was positive in 114 (68.7%) patients, showing a statistically positive relationship. Among 63 FOBT negative patients, 29 (17%) cases were CEA positive. Thus, the CEA/FOBT dual test could detect CRC in 79.5% of the patients (132/166). The sensitivity and specificity of the dual FOBT/CEA test was 79.5% and 97.9%, respectively. Conclusions The FOBT/CEA dual test has increased sensitivity compared to the FOBT test and may have merit as a screening device for colorectal cancer. Population-based studies are required to confirm this potential.
      PubDate: 2017-02-03
      DOI: 10.1007/s10353-017-0464-2
       
  • Laparoscopic removal of an accessory spleen for recurrent idiopathic
           thrombocytopenic purpura 5 years after laparoscopic splenectomy using
           perioperative eltrombopag conditioning
    • Authors: Hugo Bonatti; Daniel Medina; Natalia Kubicki; Stephen Kavic
      Abstract: Summary Background Treatment of idiopathic thrombocytopenic purpura (ITP) refractory to medical management consists of splenectomy with a high success rate. Recurrent ITP may be due to re-growth of a missed accessory spleen. Methods The clinical course of a 59-year-old female who had undergone laparoscopic splenectomy for ITP refractory to medical management 5 years ago developed a sudden drop in her platelet count to as low as 1 K/ml and she developed purpura. Results On liver/spleen scan and CT scan a 5 × 5 cm mass containing splenic tissue was found close to the tail of the pancreas. Eltrombopag (Promacta®) was used to stabilize her platelet count. During laparoscopy dense adhesion of the omentum to the abdominal wall and stomach from her previous splenectomy had to be divided. The colon was identified, the lesser sack opened through the gastrocolic ligament and the splenic flexure was taken down. The stomach was lifted anteriorly and medially to expose the tail of the pancreas and superior and dorsal to the pancreas at the previous splenic hilum the mass was identified and carefully dissected off the pancreas, kidney and adrenal gland. An endo GI with a white load was used to divide the vascular pedicle, which originated from a side branch of the splenic artery and splenic vein at the tail of the pancreas and secured with an endoloop. The accessory spleen was placed into an endobag, cut in small pieces and removed through the 10–12 mm port. The patient recovered well from the procedure without any complications and her platelet count normalized within a few weeks. Discussion Re-growth of splenic tissue causing recurrent ITP is a rare condition but should be considered. Laparoscopic removal of accessory spleens can be safely done. Newly developed agents are helpful in the management of ITP patients.
      PubDate: 2017-01-18
      DOI: 10.1007/s10353-016-0461-x
       
  • Doing the job in surgery 2017: you and your theories
    • Authors: F. M. Riegler
      PubDate: 2017-01-13
      DOI: 10.1007/s10353-016-0462-9
       
  • Marfan syndrome presenting with abdominal aortic aneurysm during pregnancy
    • Authors: J. Pasternak; M. Kaćanski; N. Budakov
      Abstract: Summary Methods We report a case of successfully performed Caesarean section followed by reconstruction of the abdominal aorta in a patient with Marfan syndrome. Results A 35-year-old woman at 37 weeks’ gestation in her second pregnancy was referred with abdominal aortic aneurysm. On admission she was asymptomatic, haemodynamically stable, and without clinical and radiological signs of rupture. Magnetic resonance imaging confirmed that the infrarenal aortic aneurysm continued to the right common iliac artery. Following preoperative assessment, it was decided to finalize gestation and reconstruct the aorta in a one-stage procedure. After a median xyphopubic laparotomy, Mizgav–Ladach Caesarean section and Pomeroy tubal sterilization were performed, followed by aneurysmectomy and aorto-bilateral iliac artery bypass. The postoperative course was uneventful. Both mother and child were doing well at follow-up 3, 9 and 12 months after the intervention. Conclusion To the best of our knowledge, this is the first case of true abdominal aortic aneurysm repair and Caesarean section as a one-stage procedure.
      PubDate: 2016-12-08
      DOI: 10.1007/s10353-016-0456-7
       
  • Perioperative fluid management
    • Authors: Martin W. Dünser; Arthur Kwizera
      PubDate: 2016-12-01
      DOI: 10.1007/s10353-016-0455-8
       
  • Effect of different doses of 2‑aminoethoxydiphenyl borate on intestinal
           ischemia-reperfusion injury
    • Authors: Murat Basbug; Murat Yildar; İsmail Yaman; Faruk Cavdar; Ömer Faruk Özkan; Hasan Aksit; Musa Ozgür Ozyigit; Figen Aslan; Hayrullah Derici
      Abstract: Summary Background Acute mesenteric ischemia is a life-threatening clinical entity. 2‑Aminoethoxydiphenyl borate (2-APB) is a membrane-permeable modulator of intracellular inositol triphosphate-induced calcium release. We investigated the effects of different 2‑APB doses on intestinal ischemia-reperfusion injury in an experimental rat model. Methods We divided 24 Wistar albino rats into four groups: sham, control, ischemia-reperfusion +2 mg/kg 2‑APB, and ischemia-reperfusion +4 mg/kg 2‑APB. The sham group only underwent laparotomy for 1 h 30 min. A 30-min period of mesenteric ischemia was induced in the control and two treatment groups, followed by 1 h of reperfusion. Before the laparotomy, 2 mg/kg and 4 mg/kg 2‑APB was administered i.v. in the treatments groups, and blood samples were collected after reperfusion. Serum levels of malondialdehyde, superoxide dismutase, glutathione, total antioxidant capacity, tumor necrosis factor (TNF)-α, and interleukin-6 were analyzed. Intestinal tissues were taken for histopathological, DNA fragmentation, and terminal deoxynucleotidyl transferase dUTP nick end labeling analyses to determine the proportion of apoptotic cells. Results 2-APB reduced serum malondialdehyde, TNF-α, and interleukin-6 levels. However, superoxide dismutase and total antioxidant capacity levels increased significantly in the 4‑mg/kg 2‑APB group (p < 0.05). The intestinal histopathological injury scores were significantly higher in the control group; these injuries were prevented in the 4‑mg/kg 2‑APB dose group. DNA damage after ischemia-perfusion decreased significantly in the 4‑mg/kg 2‑APB group compared with the control group. Conclusion 2-APB decreases oxidative stress and cell injury. Administering 4 mg/kg 2‑APB prevented ischemia-perfusion injury by diminishing histological damage.
      PubDate: 2016-11-16
      DOI: 10.1007/s10353-016-0452-y
       
 
 
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