for Journals by Title or ISSN
for Articles by Keywords

Publisher: Springer-Verlag (Total: 2354 journals)

 A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z  

  First | 3 4 5 6 7 8 9 10 | Last   [Sort by number of followers]   [Restore default list]

Showing 1201 - 1400 of 2354 Journals sorted alphabetically
J. of Clinical Geropsychology     Hybrid Journal   (Followers: 1)
J. of Clinical Immunology     Hybrid Journal   (Followers: 14, SJR: 1.332, h-index: 75)
J. of Clinical Monitoring and Computing     Hybrid Journal   (Followers: 1, SJR: 0.661, h-index: 37)
J. of Clinical Psychology in Medical Settings     Hybrid Journal   (Followers: 13, SJR: 0.46, h-index: 34)
J. of Cluster Science     Hybrid Journal   (SJR: 0.416, h-index: 31)
J. of Coal Science and Engineering (China)     Hybrid Journal   (SJR: 0.188, h-index: 8)
J. of Coastal Conservation     Hybrid Journal   (Followers: 7, SJR: 0.474, h-index: 25)
J. of Coatings Technology and Research     Hybrid Journal   (Followers: 5, SJR: 0.425, h-index: 25)
J. of Combinatorial Optimization     Hybrid Journal   (Followers: 6, SJR: 1.093, h-index: 34)
J. of Communications Technology and Electronics     Hybrid Journal   (Followers: 2, SJR: 0.29, h-index: 16)
J. of Community Genetics     Hybrid Journal   (Followers: 1, SJR: 0.727, h-index: 14)
J. of Community Health     Hybrid Journal   (Followers: 8, SJR: 0.921, h-index: 44)
J. of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology     Hybrid Journal   (Followers: 9, SJR: 1.087, h-index: 74)
J. of Comparative Physiology B : Biochemical, Systemic, and Environmental Physiology     Hybrid Journal   (Followers: 4, SJR: 1.126, h-index: 59)
J. of Compassionate Health Care     Open Access   (Followers: 3)
J. of Computational Analysis and Applications     Hybrid Journal   (SJR: 0.291, h-index: 19)
J. of Computational Electronics     Hybrid Journal   (Followers: 4, SJR: 0.511, h-index: 20)
J. of Computational Neuroscience     Hybrid Journal   (Followers: 25, SJR: 1.068, h-index: 60)
J. of Computer and Systems Sciences Intl.     Hybrid Journal   (SJR: 0.27, h-index: 13)
J. of Computer Science and Technology     Open Access   (Followers: 5, SJR: 0.437, h-index: 31)
J. of Computer Virology and Hacking Techniques     Hybrid Journal   (Followers: 6, SJR: 0.151, h-index: 2)
J. of Computer-Aided Molecular Design     Hybrid Journal   (Followers: 3, SJR: 0.995, h-index: 78)
J. of Computers in Education     Hybrid Journal   (Followers: 12)
J. of Computing in Higher Education     Hybrid Journal   (Followers: 13, SJR: 0.363, h-index: 21)
J. of Consumer Policy     Hybrid Journal   (Followers: 7, SJR: 0.704, h-index: 30)
J. of Contemporary Mathematical Analysis     Hybrid Journal   (SJR: 0.237, h-index: 5)
J. of Contemporary Physics (Armenian Academy of Sciences)     Hybrid Journal   (Followers: 11, SJR: 0.197, h-index: 6)
J. of Contemporary Psychotherapy     Hybrid Journal   (Followers: 6, SJR: 0.397, h-index: 23)
J. of Control Theory and Applications     Hybrid Journal   (Followers: 2, SJR: 0.359, h-index: 19)
J. of Control, Automation and Electrical Systems     Hybrid Journal   (Followers: 9, SJR: 0.231, h-index: 9)
J. of Crop Science and Biotechnology     Hybrid Journal   (Followers: 7)
J. of Cross-Cultural Gerontology     Hybrid Journal   (Followers: 6, SJR: 0.631, h-index: 29)
J. of Cryptographic Engineering     Partially Free   (Followers: 5, SJR: 0.989, h-index: 11)
J. of Cryptology     Hybrid Journal   (Followers: 3, SJR: 1.443, h-index: 55)
J. of Cultural Economics     Hybrid Journal   (Followers: 3, SJR: 0.539, h-index: 29)
J. of Database Marketing & Customer Strategy Management     Hybrid Journal   (Followers: 9, SJR: 0.149, h-index: 8)
J. of Derivatives & Hedge Funds     Hybrid Journal   (Followers: 8, SJR: 0.114, h-index: 5)
J. of Developmental and Physical Disabilities     Hybrid Journal   (Followers: 8, SJR: 0.574, h-index: 29)
J. of Digital Imaging     Hybrid Journal   (Followers: 10, SJR: 0.578, h-index: 35)
J. of Direct Data and Digital Marketing Practice     Hybrid Journal   (Followers: 8, SJR: 0.154, h-index: 6)
J. of Dynamical and Control Systems     Hybrid Journal   (Followers: 1, SJR: 0.4, h-index: 26)
J. of Dynamics and Differential Equations     Hybrid Journal   (SJR: 1.418, h-index: 31)
J. of Earth Science     Hybrid Journal   (Followers: 10, SJR: 0.483, h-index: 16)
J. of Earth System Science     Open Access   (Followers: 51, SJR: 0.448, h-index: 32)
J. of East Asian Linguistics     Hybrid Journal   (Followers: 6, SJR: 0.537, h-index: 20)
J. of Echocardiography     Hybrid Journal   (Followers: 4, SJR: 0.22, h-index: 3)
J. of Ecology and Environment     Open Access   (Followers: 1)
J. of Economic Growth     Hybrid Journal   (Followers: 25, SJR: 3.273, h-index: 63)
J. of Economic Interaction and Coordination     Hybrid Journal   (SJR: 0.263, h-index: 12)
J. of Economics     Hybrid Journal   (Followers: 17, SJR: 0.418, h-index: 23)
J. of Economics and Finance     Hybrid Journal   (Followers: 6, SJR: 0.272, h-index: 19)
J. of Educational Change     Hybrid Journal   (Followers: 8, SJR: 0.961, h-index: 21)
J. of Elasticity     Hybrid Journal   (Followers: 6, SJR: 0.851, h-index: 45)
J. of Electroceramics     Hybrid Journal   (SJR: 0.577, h-index: 57)
J. of Electronic Materials     Hybrid Journal   (Followers: 5, SJR: 0.609, h-index: 75)
J. of Electronic Testing     Hybrid Journal   (Followers: 2, SJR: 0.372, h-index: 27)
J. of Electronics (China)     Hybrid Journal   (Followers: 4, SJR: 0.112, h-index: 9)
J. of Elementary Science Education     Hybrid Journal   (Followers: 9)
J. of Elliptic and Parabolic Equations     Hybrid Journal  
J. of Engineering Mathematics     Hybrid Journal   (SJR: 0.347, h-index: 37)
J. of Engineering Physics and Thermophysics     Hybrid Journal   (Followers: 1, SJR: 0.288, h-index: 11)
J. of Engineering Research     Open Access   (Followers: 1, SJR: 0.145, h-index: 5)
J. of Engineering Thermophysics     Hybrid Journal   (Followers: 4, SJR: 0.763, h-index: 9)
J. of Environmental Studies and Sciences     Partially Free   (Followers: 2)
J. of Ethology     Hybrid Journal   (Followers: 2, SJR: 0.609, h-index: 25)
J. of Evolution Equations     Hybrid Journal   (SJR: 0.826, h-index: 26)
J. of Evolutionary Biochemistry and Physiology     Hybrid Journal   (SJR: 0.145, h-index: 11)
J. of Evolutionary Economics     Hybrid Journal   (Followers: 8, SJR: 0.492, h-index: 52)
J. of Experimental and Theoretical Physics     Hybrid Journal   (Followers: 3, SJR: 0.458, h-index: 39)
J. of Experimental Criminology     Hybrid Journal   (Followers: 52, SJR: 1.445, h-index: 28)
J. of Failure Analysis and Prevention     Hybrid Journal   (Followers: 5, SJR: 0.261, h-index: 15)
J. of Family and Economic Issues     Hybrid Journal   (Followers: 6, SJR: 0.396, h-index: 32)
J. of Family Violence     Hybrid Journal   (Followers: 39, SJR: 0.639, h-index: 56)
J. of Financial Services Marketing     Hybrid Journal   (Followers: 3, SJR: 0.273, h-index: 10)
J. of Financial Services Research     Hybrid Journal   (Followers: 25, SJR: 0.572, h-index: 36)
J. of Fixed Point Theory and Applications     Hybrid Journal   (SJR: 0.644, h-index: 13)
J. of Fluorescence     Hybrid Journal   (Followers: 3, SJR: 0.465, h-index: 56)
J. of Food Measurement and Characterization     Hybrid Journal   (SJR: 0.307, h-index: 4)
J. of Food Science and Technology     Hybrid Journal   (Followers: 6, SJR: 0.441, h-index: 29)
J. of Forest Research     Hybrid Journal   (Followers: 3, SJR: 0.495, h-index: 27)
J. of Forestry Research     Hybrid Journal   (Followers: 4, SJR: 0.304, h-index: 14)
J. of Fourier Analysis and Applications     Hybrid Journal   (Followers: 1, SJR: 1.18, h-index: 42)
J. of Friction and Wear     Hybrid Journal   (Followers: 7, SJR: 0.373, h-index: 7)
J. of Fusion Energy     Hybrid Journal   (Followers: 3, SJR: 0.387, h-index: 19)
J. of Gambling Studies     Hybrid Journal   (Followers: 7, SJR: 1.171, h-index: 57)
J. of Gastroenterology     Hybrid Journal   (Followers: 12, SJR: 1.651, h-index: 88)
J. of Gastrointestinal Cancer     Hybrid Journal   (Followers: 4, SJR: 0.304, h-index: 39)
J. of Gastrointestinal Surgery     Hybrid Journal   (Followers: 10, SJR: 1.64, h-index: 99)
J. of General Internal Medicine     Hybrid Journal   (Followers: 18, SJR: 1.804, h-index: 134)
J. of General Plant Pathology     Hybrid Journal   (SJR: 0.554, h-index: 22)
J. of Genetic Counseling     Hybrid Journal   (Followers: 6, SJR: 0.902, h-index: 39)
J. of Genetics     Open Access   (Followers: 5, SJR: 0.458, h-index: 28)
J. of Geodesy     Hybrid Journal   (Followers: 9, SJR: 2.173, h-index: 56)
J. of Geographical Sciences     Hybrid Journal   (Followers: 1, SJR: 0.8, h-index: 23)
J. of Geographical Systems     Hybrid Journal   (Followers: 4, SJR: 0.822, h-index: 39)
J. of Geometric Analysis     Hybrid Journal   (Followers: 2, SJR: 1.491, h-index: 27)
J. of Geometry     Hybrid Journal   (Followers: 1, SJR: 0.272, h-index: 15)
J. of Global Optimization     Hybrid Journal   (Followers: 4, SJR: 0.992, h-index: 60)
J. of Global Policy and Governance     Hybrid Journal   (Followers: 11)
J. of Grid Computing     Hybrid Journal   (Followers: 1, SJR: 1.414, h-index: 37)
J. of Happiness Studies     Hybrid Journal   (Followers: 26, SJR: 0.881, h-index: 39)
J. of Hematopathology     Hybrid Journal   (Followers: 3, SJR: 0.2, h-index: 13)
J. of Heuristics     Hybrid Journal   (Followers: 4, SJR: 1.308, h-index: 50)
J. of High Energy Physics     Hybrid Journal   (Followers: 18, SJR: 1.052, h-index: 153)
J. of Homotopy and Related Structures     Hybrid Journal   (SJR: 0.232, h-index: 2)
J. of Housing and the Built Environment     Hybrid Journal   (Followers: 7, SJR: 0.648, h-index: 28)
J. of Huazhong University of Science and Technology [Medical Sciences]     Hybrid Journal   (SJR: 0.344, h-index: 19)
J. of Ichthyology     Hybrid Journal   (Followers: 3, SJR: 0.304, h-index: 10)
J. of Immigrant and Minority Health     Hybrid Journal   (Followers: 13, SJR: 0.759, h-index: 37)
J. of Inclusion Phenomena and Macrocyclic Chemistry     Hybrid Journal   (Followers: 1, SJR: 0.331, h-index: 46)
J. of Indian Council of Philosophical Research     Hybrid Journal  
J. of Indian Philosophy     Hybrid Journal   (Followers: 12, SJR: 0.127, h-index: 12)
J. of Industrial Microbiology and Biotechnology     Hybrid Journal   (Followers: 16, SJR: 0.966, h-index: 80)
J. of Industry, Competition and Trade     Hybrid Journal   (Followers: 9, SJR: 0.327, h-index: 15)
J. of Infection and Chemotherapy     Hybrid Journal   (Followers: 1, SJR: 0.673, h-index: 46)
J. of Information Technology     Hybrid Journal   (Followers: 59, SJR: 1.474, h-index: 55)
J. of Information Technology Teaching Cases     Hybrid Journal   (Followers: 10)
J. of Infrared, Millimeter and Terahertz Waves     Hybrid Journal   (Followers: 2, SJR: 1.25, h-index: 36)
J. of Inherited Metabolic Disease     Hybrid Journal   (Followers: 2, SJR: 1.389, h-index: 77)
J. of Inorganic and Organometallic Polymers and Materials     Partially Free   (Followers: 9, SJR: 0.338, h-index: 33)
J. of Insect Behavior     Hybrid Journal   (Followers: 8, SJR: 0.569, h-index: 39)
J. of Insect Conservation     Hybrid Journal   (Followers: 10, SJR: 0.872, h-index: 43)
J. of Intelligent and Robotic Systems     Hybrid Journal   (Followers: 3, SJR: 0.629, h-index: 43)
J. of Intelligent Information Systems     Hybrid Journal   (Followers: 1, SJR: 0.691, h-index: 43)
J. of Intelligent Manufacturing     Hybrid Journal   (Followers: 3, SJR: 1.397, h-index: 54)
J. of Interventional Cardiac Electrophysiology     Hybrid Journal   (SJR: 0.93, h-index: 43)
J. of Intl. Business Studies     Hybrid Journal   (Followers: 35, SJR: 4.208, h-index: 130)
J. of Intl. Entrepreneurship     Hybrid Journal   (Followers: 10, SJR: 0.549, h-index: 23)
J. of Intl. Migration and Integration / Revue de l integration et de la migration internationale     Hybrid Journal   (Followers: 14, SJR: 0.308, h-index: 13)
J. of Intl. Relations and Development     Hybrid Journal   (Followers: 21, SJR: 0.793, h-index: 22)
J. of Labor Research     Hybrid Journal   (Followers: 19, SJR: 0.394, h-index: 27)
J. of Logic, Language and Information     Hybrid Journal   (Followers: 7, SJR: 0.288, h-index: 25)
J. of Low Temperature Physics     Hybrid Journal   (Followers: 3, SJR: 0.531, h-index: 52)
J. of Machinery Manufacture and Reliability     Hybrid Journal   (Followers: 2, SJR: 0.203, h-index: 7)
J. of Mammalian Evolution     Hybrid Journal   (Followers: 5, SJR: 1.134, h-index: 37)
J. of Mammary Gland Biology and Neoplasia     Hybrid Journal   (Followers: 2, SJR: 2.252, h-index: 83)
J. of Management and Governance     Hybrid Journal   (Followers: 14, SJR: 0.805, h-index: 33)
J. of Management Control     Hybrid Journal   (Followers: 4, SJR: 0.605, h-index: 6)
J. of Marine Science and Application     Hybrid Journal   (Followers: 2, SJR: 0.439, h-index: 11)
J. of Marine Science and Technology     Hybrid Journal   (Followers: 3, SJR: 0.235, h-index: 19)
J. of Maritime Archaeology     Hybrid Journal   (Followers: 22, SJR: 0.228, h-index: 8)
J. of Market-Focused Management     Hybrid Journal   (Followers: 2)
J. of Marketing Analytics     Hybrid Journal   (Followers: 4)
J. of Material Cycles and Waste Management     Hybrid Journal   (Followers: 3, SJR: 0.449, h-index: 22)
J. of Materials Engineering and Performance     Hybrid Journal   (Followers: 24, SJR: 0.544, h-index: 40)
J. of Materials Science     Hybrid Journal   (Followers: 21, SJR: 0.836, h-index: 123)
J. of Materials Science : Materials in Electronics     Hybrid Journal   (Followers: 6)
J. of Materials Science : Materials in Medicine     Hybrid Journal   (Followers: 5)
J. of Mathematical Biology     Hybrid Journal   (Followers: 11, SJR: 1.011, h-index: 71)
J. of Mathematical Chemistry     Hybrid Journal   (Followers: 4, SJR: 0.497, h-index: 45)
J. of Mathematical Fluid Mechanics     Hybrid Journal   (Followers: 8, SJR: 1.22, h-index: 22)
J. of Mathematical Imaging and Vision     Hybrid Journal   (Followers: 5, SJR: 0.901, h-index: 53)
J. of Mathematical Modelling and Algorithms     Hybrid Journal   (Followers: 2, SJR: 0.414, h-index: 23)
J. of Mathematical Sciences     Hybrid Journal   (SJR: 0.272, h-index: 23)
J. of Mathematics Teacher Education     Hybrid Journal   (Followers: 18, SJR: 1.062, h-index: 20)
J. of Maxillofacial and Oral Surgery     Hybrid Journal   (Followers: 3)
J. of Mechanical Science and Technology     Hybrid Journal   (Followers: 6, SJR: 0.589, h-index: 26)
J. of Medical and Biological Engineering     Hybrid Journal   (Followers: 1, SJR: 0.387, h-index: 18)
J. of Medical Humanities     Hybrid Journal   (Followers: 22, SJR: 0.299, h-index: 18)
J. of Medical Systems     Hybrid Journal   (Followers: 1, SJR: 0.717, h-index: 44)
J. of Medical Toxicology     Hybrid Journal   (Followers: 6, SJR: 0.874, h-index: 28)
J. of Medical Ultrasonics     Hybrid Journal   (Followers: 2, SJR: 0.18, h-index: 13)
J. of Medicine and the Person     Hybrid Journal  
J. of Membrane Biology     Hybrid Journal   (Followers: 2, SJR: 0.738, h-index: 82)
J. of Micro-Bio Robotics     Hybrid Journal   (SJR: 0.28, h-index: 3)
J. of Microbiology     Hybrid Journal   (Followers: 8, SJR: 0.741, h-index: 43)
J. of Mining Science     Hybrid Journal   (Followers: 4, SJR: 0.317, h-index: 16)
J. of Molecular Evolution     Hybrid Journal   (Followers: 9, SJR: 0.952, h-index: 108)
J. of Molecular Histology     Hybrid Journal   (Followers: 4, SJR: 0.755, h-index: 48)
J. of Molecular Medicine     Hybrid Journal   (Followers: 14, SJR: 2.165, h-index: 113)
J. of Molecular Modeling     Hybrid Journal   (Followers: 4, SJR: 0.466, h-index: 50)
J. of Molecular Neuroscience     Partially Free   (Followers: 11, SJR: 0.988, h-index: 69)
J. of Mountain Science     Hybrid Journal   (Followers: 3, SJR: 0.418, h-index: 15)
J. of Muscle Research and Cell Motility     Hybrid Journal   (Followers: 1, SJR: 1.264, h-index: 55)
J. of Nanoparticle Research     Hybrid Journal   (Followers: 3, SJR: 0.583, h-index: 84)
J. of Natural Medicines     Hybrid Journal   (SJR: 0.602, h-index: 28)
J. of Near-Death Studies     Hybrid Journal   (Followers: 2)
J. of Nephrology     Hybrid Journal   (Followers: 4, SJR: 0.689, h-index: 55)
J. of Network and Systems Management     Hybrid Journal   (SJR: 0.466, h-index: 26)
J. of Neural Transmission     Hybrid Journal   (Followers: 2, SJR: 1.034, h-index: 86)
J. of Neuro-Oncology     Hybrid Journal   (Followers: 3, SJR: 1.274, h-index: 90)
J. of Neuroimmune Pharmacology     Hybrid Journal   (Followers: 1, SJR: 1.662, h-index: 45)
J. of Neurology     Hybrid Journal   (Followers: 17, SJR: 1.429, h-index: 105)
J. of NeuroVirology     Hybrid Journal   (Followers: 1, SJR: 0.979, h-index: 69)
J. of Nondestructive Evaluation     Hybrid Journal   (Followers: 11, SJR: 0.863, h-index: 27)
J. of Nonlinear Science     Hybrid Journal   (Followers: 1, SJR: 1.887, h-index: 42)
J. of Nonverbal Behavior     Hybrid Journal   (Followers: 5, SJR: 0.723, h-index: 47)
J. of Nuclear Cardiology     Hybrid Journal   (SJR: 1.024, h-index: 68)
J. of Nutrition, Health and Aging     Hybrid Journal   (Followers: 26, SJR: 0.919, h-index: 60)
J. of Obstetrics and Gynecology of India     Hybrid Journal   (Followers: 5, SJR: 0.214, h-index: 6)
J. of Occupational Rehabilitation     Hybrid Journal   (Followers: 16, SJR: 0.811, h-index: 51)
J. of Ocean Engineering and Marine Energy     Hybrid Journal   (Followers: 3)
J. of Ocean University of China (English Edition)     Hybrid Journal   (Followers: 1, SJR: 0.237, h-index: 11)
J. of Oceanography     Hybrid Journal   (Followers: 10, SJR: 0.796, h-index: 52)
J. of Ocular Biology, Diseases, and Informatics     Hybrid Journal   (SJR: 0.183, h-index: 11)
J. of Optical and Fiber Communications Reports     Hybrid Journal   (Followers: 4)
J. of Optics     Hybrid Journal   (Followers: 8, SJR: 0.214, h-index: 8)
J. of Optimization Theory and Applications     Hybrid Journal   (Followers: 5, SJR: 0.898, h-index: 65)
J. of Ornithology     Hybrid Journal   (Followers: 24)
J. of Orofacial Orthopedics / Fortschritte der Kieferorthopädie     Hybrid Journal   (SJR: 0.574, h-index: 33)

  First | 3 4 5 6 7 8 9 10 | Last   [Sort by number of followers]   [Restore default list]

Journal Cover European Surgery
  [SJR: 0.171]   [H-I: 15]   [7 followers]  Follow
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1682-4016 - ISSN (Online) 1682-8631
   Published by Springer-Verlag Homepage  [2354 journals]
  • Effects of teduglutide on histological parameters of intestinal
           anastomotic healing
    • Authors: Beatriz P. Costa; Maria A. Cipriano; Ana C. Gonçalves; Ana M. Abrantes; Paulo Matafome; Raquel Seiça; Ana B. Sarmento-Ribeiro; M. Filomena Botelho; Francisco Castro-Sousa
      Pages: 218 - 227
      Abstract: Summary Background Intestinal anastomotic failure continues to be one of the most relevant surgical incidents. Teduglutide is an enterotrophic long-acting equivalent of glucagon-like peptide-2 (GLP-2) recommended for the treatment of adult patients with short bowel syndrome. This study evaluates the effects of short-term teduglutide administration on histological parameters of intestinal anastomotic healing in an animal model. Methods Wistar rats (n = 31) were submitted to ileal resection and standard anastomosis, with or without postoperative teduglutide ministration, and sacrificed at the third or seventh day with tissue and blood sampling. Intestinal anastomotic healing was assessed with the modified Houdart–Hutschenreiter classification after hematoxylin and eosin staining. Collagen content and distribution were evaluated with the Gordon and Sweet technique; neoangiogenesis and epithelial proliferation indexes with anti-CD31 and anti-Ki67 immunostaining, respectively. GLP-2 plasma levels were determined by quantitative enzyme immunoassay. Results Teduglutide administration was associated with higher levels of reepithelialization (P = 0.022) and a higher neoangiogenesis index (neovessel density = 16.0 ± 10.8/mm2 vs. 5.3 ± 3.4/mm2; P = 0.0001) at the seventh postoperative day. Lower expression of type I collagen (P = 0.015) and higher content of type III collagen (P = 0.007) in the submucosa were also documented at the seventh day in teduglutide-treated animals. Drug administration was not associated with statistically significant differences of GLP-2 plasma levels. Conclusion These findings indicate a positive impact of teduglutide on the reepithelialization and neoangiogenesis events of the proliferative phase of intestinal anastomotic repair. Additional studies are necessary to clarify its effects on the fibrogenesis process.
      PubDate: 2017-10-01
      DOI: 10.1007/s10353-017-0478-9
      Issue No: Vol. 49, No. 5 (2017)
  • Update on the management of Barrett’s esophagus in Austria
    • Authors: M. Riegler; I. Kristo; M. Nikolic; E. Rieder; S. F. Schoppmann
      Abstract: Summary Background Barrett’s esophagus (BE) is the premalignant manifestation of gastroesophageal reflux disease (GERD). Radiofrequency ablation (RFA) with and without endoscopic resection (ER) is a novel treatment for BE. Methods Here we present a single-center update of the recommendations of a recent (June 2015) interdisciplinary expert panel meeting on the management of BE with dysplasia as well as cancer-positive and cancer-negative BE. We conducted a PubMed search of studies published in 2016 and 2017 on the topic of BE and RFA. Results Our update reconfirms that BE positive for T1a cancer as well as low- and high-grade dysplasia justifies the use of RFA ± ER, offering an 80–100% rate of BE clearance. RFA ± ER of dysplastic BE is tenfold more effective for cancer prevention when compared with surveillance. Risk factors for recurrence and follow-up treatments include baseline histopathology (dysplasia/T1a cancer), esophagitis, hiatal hernia >3 cm, smoking habits, BE segments >3 cm, and >10 years of GERD symptoms. A baseline diagnosis for dysplasia and T1a cancer should include a second expert pathologist opinion. Recent data justify the use of RFA for nondysplastic BE only in controlled clinical trials. Antireflux surgery can be offered to those with function-test-proven, GERD-symptom-positive BE before, during, or after RFA ± ER. Additionally, there is growing evidence that the intake of a sugar-rich diet is positively correlated with the development of GERD, BE, and cancer. Conclusion RFA ± ER should be offered for dysplastic BE and T1a cancer after ER as well as for nondysplastic BE with additional risk factors in controlled trials. Antireflux surgery can be offered to patients with function-test-proven GERD-symptom-positive BE. Diet considerations should be included in the management of GERD and BE.
      PubDate: 2017-12-04
      DOI: 10.1007/s10353-017-0504-y
  • Bile leak from the gallbladder fossa after liver transplantation
    • Authors: Hugo J. R. Bonatti; Michael R. Corey; Joshua T. Taylor; Sunil K. Geevarghese
      Abstract: Summary Background Bile leaks are common complications following liver transplantation (LT). The majority of leaks involve the anastomosis but other sites should be considered. Bile leaks are associated with biliary peritonitis and intra-abdominal abscess formation. Subvesical bile ducts formerly called ducts of Luschka are aberrant bile ducts in the gallbladder fossa. Leaks from this structure have been reported following laparoscopic cholecystectomy. Only three cases of leaks from this duct after LT have been thus far reported. Case report A 43-year-old man with a MELD (model for end stage liver disease) score of 29 underwent an uncomplicated LT for hepatitis C–cirrhosis and reformed alcohol abuse. Four days after discharge he developed significant abdominal pain and leukocytosis of 16,000/ml; AST was 23 IU/l and total bilirubin 2.0 mg/dl. A computed tomography scan showed massive ascites and a perihepatic hematoma. Paracentesis (5 l) revealed 10,000 nucleated cells, 98% neutrophils, and a bilirubin level of 3.4 mg/dl. Antibiotics were started; endoscopic retrograde cholangiopancreatography showed a patent anastomosis but a small leak from a side branch of the right hepatic duct. A transampullary common bile duct stent was placed. The patient developed increasing abdominal pain, ileus, and underwent laparotomy during which the perihepatic hematoma was evacuated and a bile leak from a subvesical bile duct was identified and oversewn. Cultures grew Escherichia coli and antibiotics were continued. The patient recovered from the complication and the biliary stent was removed after the leak had completely sealed. The patient is alive with a well-functioning graft 4 years after the procedure. Conclusion Leaks from subvesical bile ducts are rare complications in LT recipients, but should be recognized as a source of intra-abdominal infection.
      PubDate: 2017-11-30
      DOI: 10.1007/s10353-017-0505-x
  • Combined laparoscopic cholecystectomy and deroofing of a large liver cyst
           with a two trocar technique and use of a needle grasper
    • Authors: Hugo Bonatti; Michael J. Fisher
      Abstract: Summary Background Laparoscopic cholecystectomy (LC) is usually done using four trocars; techniques to further reduce surgical trauma have been developed. Nonparasitic hepatic cysts (HC) are only treated if symptomatic or malignancy is suspected with laparoscopy becoming the preferred approach. Case report A 41-year-old African American male presented with recurrent right (R) upper quadrant (UQ) pain. He was found to have cholecystolithiasis and multiple HCs with the largest located dorsally to segments 4, 5, 8 being >10 cm in diameter. A 5 mm trocar in the left (L) UQ, a 10–12 mm umbilical trocar, and a Teleflex needle grasper between the two trocars were placed. The gallbladder (GB) was removed using a modified dome down technique due to difficult access to the hilum due to the bulging large HC. Following LC, the HC was dissected off the duodenum, gerota fascia, right adrenal gland and inferior vena cava (IVC) and thereafter, the roof was resected using a harmonic scalpel. Resection was incomplete medially due to close proximity with the hilar structures and the IVC. Also a liver wedge biopsy was done. The intra- and postoperative course were uneventful and the patient was discharged after a 23 h observation period. Pathology confirmed chronic cholecystitis, mild hepatic steatosis and inflammation and benign HC wall with chronic inflammation. The patient was asymptomatic for more than 2 years when he developed RUQ pain. On the computed tomography scan, a small recurrent HC close to the liver hilum was identified; however the cause of his pain was a kidney stone. Conclusions Combined LC and HC deroofing is a rare procedure. A minimally invasive technique should be the preferred approach. In our case only two trocars were required and the Teleflex minigrasper completely replaced a trocar-based instrument.
      PubDate: 2017-11-24
      DOI: 10.1007/s10353-017-0499-4
  • Metastasis to the esophagus from primary adenocarcinoma of the lung
    • Authors: Simone Zanghì; Stefano Siboni; Emanuele Asti; Antonella Festa; Luigi Bonavina
      Abstract: Summary Background Metastasis to the esophagus is a rare event that can occur by direct infiltration of malignancies from nearby organs or, more infrequently, via lymphatic or hematogenous spread. Methods We reviewed the hospital charts of a patient presenting with dysphagia in whom a distant metastasis to the esophagus from a primary lung adenocarcinoma was documented. A review of the pertinent literature was performed. Results A 74 year-old man with previous history of lung cancer and transoral septum stapling for Zenker’s diverticulum presented with subtotal dysphagia and chest pain. On upper gastrointestinal endoscopy, a vegetating mass of the middle esophagus, covered by fragile and bleeding mucosa, was found. Esophageal biopsies demonstrated metastasis from a poorly differentiated lung adenocarcinoma with evidence of thyroid transcription factor (TTF) positive neoplastic cells. A computed tomography scan revealed a radiopaque mass in the upper right lung. Combination chemotherapy was initiated and a partially covered stent was placed endoscopically. Conclusions A distant metastatic tumor to the esophagus with mucosal infiltration is an exceptional event. In our patient, immunohistochemistry was useful to confirm the diagnosis of primary lung carcinoma.
      PubDate: 2017-11-24
      DOI: 10.1007/s10353-017-0501-1
  • Clinical and oncological outcomes of single-incision laparoscopic surgery
           for transverse colon cancer
    • Authors: Yasumitsu Hirano; Chikashi Hiranuma; Masakazu Hattori; Kenji Douden; Yasuo Hashizume; Keizo Tanuguchi
      Abstract: Summary Background Single institutional consecutive experiences with single-incision laparoscopic surgery (SILS) for transverse colon cancer are reviewed, and the resulting clinical and oncological outcomes are evaluated. Methods In all, 59 patients (29 women) with a median age of 71.0 years were treated with SILS for clinically diagnosed colon cancer. A tumor located at the hepatic flexure or within about 10 cm distal to the hepatic flexure was treated by right hemicolectomy. Extended right hemicolectomy was performed in cancer which required the ligation of the root of the mid-colic artery. A tumor at the splenic flexure was treated by left hemicolectomy, and transverse colectomy was performed for other transverse colon tumors. Results In 54 patients treated with SILS, the mean skin incision length was 2.67 cm: 26 right hemi-colectomies, 19 transverse colectomies, 4 extended right hemi-colectomies and 2 left hemi-colectomies were performed in this series. The mean operative time and blood loss were 181.9 min and 44.9 mL, respectively. The mean number of harvested lymph nodes was 29.0. Early post-operative complications were occurred in 2 patients (3.7%). The patients were discharged after a mean period of 13.0 postoperative days. Five (11.1%) tumor recurrences or metastases occurred in 45 patients with Stage I to Stage III disease with the median follow-up of 30 months. Conclusions Our initial experiences showed that SILS can be used to treat transverse colon cancer with good clinical and mid-term oncological outcomes.
      PubDate: 2017-11-16
      DOI: 10.1007/s10353-017-0498-5
  • A propensity score matched case-control comparative study of totally
           laparoscopic distal gastrectomy and laparoscopic-assisted distal
           gastrectomy for early gastric cancer
    • Authors: Sung Don Oh; Sung Jin Oh; Byoung Jo Suh; Jin Yong Shin; Jong Kwon Park
      Abstract: Summary Background Intracorporeal anastomosis remains a difficult procedure. This study was designed to clarify the advantage of totally laparoscopic distal gastrectomy (TLDG) compared with laparoscopic-assisted distal gastrectomy (LADG) regarding short-term surgical outcomes. Methods We retrospectively identified 273 patients who were preoperatively diagnosed with early gastric cancer and underwent LADG or TLDG between March 2010 and May 2016. A propensity score matching analysis was used to create patient groups matched for sex, age, body mass index, previous abdominal surgery history, and American Society of Anesthesiologist score. Results The TLDG group showed statistically shorter operative time (250.9 ± 4.6 min vs. 281.8 ± 7.3 min, p = 0.000), lower estimated blood loss (77.6 ± 3.3 ml vs. 122.4 ± 6.2 ml, p = 0.000), and shorter time to first flatus after surgery (2.9 ± 0.1 days vs. 3.2 ± 0.1 days, p = 0.001) compared with the LADG group. However, there was no specific superiority in terms of the inflammatory profiles on postoperative days 1, 2, 4, and 7 between the two groups. Complication rates were also similar in the two groups (13.3% LADG vs. 6.1% TLDG). Conclusion This study shows that TLDG for early gastric cancer is a safe surgical procedure and superior in cosmesis compared with LADG.
      PubDate: 2017-11-06
      DOI: 10.1007/s10353-017-0495-8
  • Risk reduction of hypocalcemia after thyroidectomy
    • Authors: Cathleen J. O’Neill; M. Jinih; S. Boyle; S. A. Brennan; M. Majeed; A. A. Achakzai; H. P. Redmond
      Abstract: Summary Background Hypocalcemia is a well-described complication associated with total thyroidectomies. We investigated the role of early intraoperative parathyroid hormone (PTH) measurement and relative differences in PTH in predicting those patients at risk of postoperative hypocalcemia. Methods This was a retrospective study. Inclusion criteria were all patients undergoing completion/total thyroidectomy from March 2016 to March 2017 under a single surgeon. All patients had PTH assay performed at induction of anesthesia and intraoperatively (IOPTH) following thyroid excision. The differences in mean between preoperative vs. intraoperative PTH were assessed using a Wilcoxon rank-sum test. Relationships between PTH and ∆PTH with postoperative calcium levels were assessed using Pearson’s correlation and a binomial regression analysis was also performed. Results The cohort comprised 25 female and three male patients. The mean IOPTH level was significantly lower than the preoperative levels (18.6 ± 19.4 vs. 52.11 ± 46.3; two-tailed p <0.0001). The mean postoperative calcium level was significantly lower than the preoperative calcium level (2.22 ± 0.2 mmol/l vs. 2.29 ± 0.16 mmol/l, respectively, p = 0.162). Attempted correlation of IOPTH levels with postoperative calcium yielded a Pearson’s correlation coefficient R of 0.064 (p = 0.748). A weakly negative correlation was found between ∆PTH and postoperative calcium, R = −0.216. Binomial logistic regression analysis was not statistically significant for this cohort (X2 = 10.8; p = 0.216). Conclusion We found no association between PTH levels and postoperative calcium levels. ∆PTH may be a superior parameter in predicting postoperative hypocalcemia in total thyroidectomy. Post hoc analysis of existing study databases could further demonstrate the advantage of ∆PTH in risk stratification.
      PubDate: 2017-11-03
      DOI: 10.1007/s10353-017-0496-7
  • Videoendoscopic pilonidal sinus surgery: early results with a new
    • Authors: Enver Kunduz; Ufuk Oguz Idiz; Erhan Aysan; Mehmet Guzel; Yunus Yapalak; Lutfullah Baskoy
      Abstract: Summary Background We adapted a laparoscopic surgical technique to sacrococcygeal pilonidal sinus disease (SPSD) treatment. Methods The study included 18 cases. All patients were operated on under spinal anesthesia. Two 5‑mm trocars were placed 5 cm lateral to the intergluteal area. Sinus tracts, granulation tissues, and surrounding inflamed areas were dissected and removed through the trocar openings. Results Recurrence was detected in two patients within the first 3 months. Skin burn was observed in one patient and hematoma developed in another patient. All recurrences and complications were seen in the first group of nine cases. The mean follow-up period was 71.5 months (58–79 months). The mean operation time was 44 min and the mean hospital stay was 1 day. Conclusion Herein, we describe for the first time a lateral access videoendoscopic technique. After a learning curve, this minimally invasive new technique for SPSD treatment may reduce recurrences, wound complications, and the wide incision required by other techniques.
      PubDate: 2017-11-03
      DOI: 10.1007/s10353-017-0497-6
  • Dietary sugar and Barrett’s esophagus
    • Authors: M. Riegler; I. Kristo; R. Asari; E. Rieder; S. F. Schoppmann
      Abstract: Summary Introduction Barrett’s esophagus (BE) represents the premalignant morphology of gastroesophageal reflux disease (GERD). Evidence indicates a positive correlation between GERD vs. obesity and increased sugar consumption. Methods Here we analyzed recently published data (2006–2017) on the role of dietary sugar intake for BE development (main focus year 2017). Results Recent investigations found a positive association between obesity, hip waist ratio and dietary sugar intake and Barrett’s esophagus. Conclusion Sugar intake positively associates with BE. A low carbohydrate diet should be recommended for persons with BE and GERD.
      PubDate: 2017-10-24
      DOI: 10.1007/s10353-017-0494-9
  • Surgery and quantum physics
    • Authors: F. M. Riegler
      PubDate: 2017-10-04
      DOI: 10.1007/s10353-017-0493-x
  • Preoperative diagnosis of hiatal hernia: barium swallow X-ray,
           high-resolution manometry, or endoscopy'
    • Authors: Michael Weitzendorfer; Gernot Köhler; Stavros A. Antoniou; Leo Pallwein-Prettner; Lisa Manzenreiter; Philipp Schredl; Klaus Emmanuel; Oliver Owen Koch
      Abstract: Summary Background The assessment of hiatal hernias (HH) is typically done with barium swallow X‑ray, upper endoscopy, and by high-resolution esophageal manometry (HRM). The aim of this study was to assess the clinical utility of these methods in terms of HH detection and their correlation to gastroesophageal reflux disease (GERD). Methods A retrospective comparative analysis of patients with symptoms of GERD was carried out. The performance of endoscopy and HRM in diagnosing HH was assessed, taking barium swallow X‑ray as a reference. Furthermore, statistically comparative analysis between detected hernias and the presence of reflux disease in ambulatory impedance-pH monitoring (MII) was performed. Results Overall, 112 patients were analyzed. Barium swallow X‑ray showed no correlation either to HR manometrically or to endoscopically assessed HH. Significant accordance in the detection rate of HH was proved between HRM and gastroesophagoscopy (p < 0.001). Only endoscopically assessed HH showed a significant correlation with GERD (p = 0.047). No correlation between detected hernias and GERD could be found either with HRM or with barium swallow X‑ray. Conclusions Barium swallow X‑ray provided the highest rate of HH detection (76.8%). For the reliable exclusion of HH prior to treatment, all three mentioned investigations appear to be necessary in order of low conformity.
      PubDate: 2017-09-19
      DOI: 10.1007/s10353-017-0492-y
  • “The abdominal catastrophe”
    • Authors: F. Cecere; R. Kafka; M. Maglione; D. Öfner; H. Wykypiel
      Abstract: Summary Introduction An open abdomen with multiple small intestinal fistulas is a highly challenging situation for the entire treating team and, in some cases, ultimately requires small bowel transplantation. Case In May 2015, a 55-year-old female patient was transferred to our department for evaluation for small bowel transplantation. Following appendectomy in childhood, the patient had had a complicated course with consecutive loss of small bowel. In May 2014, an even more complicated perforated sigma diverticulitis followed. The consequence was a small bowel high-output stoma with concomitant short-bowel syndrome. In March 2015, an attempt to reconstruct the passage failed and ended in an open abdomen with eight small intestinal fistulae, a contracted ileostomy and a defunctioned descendostomy. We firstly mobilized the stoma and conditioned the wound with almost daily changing of a vacuum dressing system (VAC®, KCI, International) by using a children’s pacifier. At 6 months after the previous abdominal operation, extensive adhesiolysis and conglomerate resection plus a jejunoileostomy and new installation of the descendostomy was performed. Approximately 80 cm of small intestine, 50 cm of colon plus the ileocecal valve could be preserved. The abdominal wall was closed cutaneously only. After 168 days of hospitalization, the patient was discharged with oral alimentation and supplementary parenteral nutrition only by night. Conclusion With considerable nursing and surgical effort, the need for intestinal transplantation with all its complications can be avoided in selected cases. A children’s pacifier can help to make vacuum-assisted closure of the wound possible.
      PubDate: 2017-09-19
      DOI: 10.1007/s10353-017-0490-0
  • Notch and its oncogenic activity in human malignancies
    • Authors: Marlena Brzozowa-Zasada; Adam Piecuch; Marek Michalski; Oliwia Segiet; Józef Kurek; Marzena Harabin-Słowińska; Romuald Wojnicz
      Abstract: Summary Background Increasing evidence has demonstrated that Notch signaling is deregulated in human hematological malignancies and solid tumors. This signaling has a protumorigenic effect but may also act as a tumor suppressor. How induction of a single pathway gives rise to the opposite effects in different cell types is still unknown. Methods This review article includes available data from peer-reviewed publications associated with the role of Notch signaling during cancer pathogenesis. Results Numerous reports have indicated that alterations in Notch signaling and its oncogenic activity were originally associated with the pathogenesis of T‑cell acute lymphoblastic leukemia/lymphoma (T-ALL), an aggressive hematologic tumor affecting children and adolescents. The possibility that Notch could play a significant role in human breast cancer development comes from studies on mouse mammary tumor virus-induced cancer. Numerous findings over the past several years have indicated that alterations in Notch signaling are also responsible for ovarian cancer development. Mention should also be made of the connection between expression of Notch 3 and increased resistance to chemotherapy, which remains a major obstacle to successful treatment. Notch as an oncogenic factor is also involved in the development of colon cancer, lung carcinoma and Kaposi’s sarcoma. Conclusion Notch is a binary cell fate determinant and its overexpression has been described as oncogenic in a wide array of human malignancies. This finding led to interest in therapeutically targeting this pathway, especially by the use of gamma-secretase inhibitors (GSIs) blocking the cleavage of Notch receptors at the cell membrane by the inhibition of Notch intracellular domain (NICD) releasing. Preclinical cancer models have revealed that GSIs suppress the growth of cancers such as pancreatic, breast and lung cancer.
      PubDate: 2017-09-18
      DOI: 10.1007/s10353-017-0491-z
  • Cholecystocolonic fistula and gallstone obstruction
    • Authors: Alberto Aiolfi; Chiara Ceriani; Marco Sozzi; Stefano Siboni; Luigi Bonavina
      Abstract: Summary Background Mechanical obstruction secondary to colonic impact of a gallstone resulting from a direct cholecystocolonic fistula is a rare event. Although spontaneous resolution has been described, surgical or endoscopic procedures may be required to relieve the obstruction. The overall complication rate related to surgical treatment is relevant because of the acute presentation in elderly patients with multiple comorbidities and high operative risk. Methods An extensive literature search over the last two decades (1997–2017) was conducted. MEDLINE, Embase, and Cochrane databases were consulted. All the articles, case reports, and case series that described the management of colonic gallstone obstruction were included in this narrative review. Results In all, 41 cases of colonic gallstone ileus were included. The majority of the patients were successfully managed with an open (78%), endoscopic (14.6%), or laparoscopic approach (4.9%). Spontaneous resolution of the mechanical obstruction was described in one case (2.5%). The overall morbidity and mortality rates of the surgical-related procedures were 31% and 9.4%, respectively. In the endoscopic groups, there was no procedure-related morbidity and mortality. Conclusion An endoscopic approach may be a better therapeutic option in selected patients with colonic gallstone obstruction unfit for surgery.
      PubDate: 2017-09-08
      DOI: 10.1007/s10353-017-0489-6
  • Multimodality locoregional treatment strategies for bridging HCC patients
           before liver transplantation
    • Authors: Georg P. Györi; D. Moritz Felsenreich; Gerd R. Silberhumer; Thomas Soliman; Gabriela A. Berlakovich
      Abstract: Summary Background It is current practice that patients with hepatocellular carcinoma (HCC) listed for liver transplantation should receive locoregional treatment if the suspected waiting time for transplantation is longer than 6 months, even in the absence of prospective randomized data. Aim of this study was the comparison of single versus multimodality locoregional treatment strategies on outcomes after liver transplantation. Methods This is a retrospective analysis of 150 HCC patients listed for liver transplantation at our center between 2004 and 2011. Outcomes were analyzed according to modified Response Evaluation Criteria in Solid Tumors (mRECIST) in relation to intention-to-treat and overall survival after liver transplantation. Results Overall, 92 patients (63%) were transplanted in this cohort. The intention-to-treat 1‑, 3‑, 5‑year waiting list survival was 80, 59, and 50% respectively. In RFA-(radiofrequency ablative) and TACE-(transarterial chemoembolisation)-based regimens, rates of transplanted patients were comparable (69 vs. 58%, p = ns). No difference was seen in overall survival after liver transplantation when comparing TACE- and RFA-based regimens. Patients receiving multimodality locoregional therapy had lower overall survival after transplantation (p = 0.05) Conclusion TACE- and RFA-based regimens showed equal outcomes in terms of transplantation rate, tumor response, and post-transplant survival. Patients in need of more than one treatment modality might identify a cohort with poorer post-transplant survival. Points of novelty Direct comparison of TACE and RFA in a multimodality setting, analysis according to mRECIST.
      PubDate: 2017-09-04
      DOI: 10.1007/s10353-017-0487-8
  • A rare case of Calot’s triangle paraganglioma
    • Authors: Alberto Oldani; Renzo Boldorini; Paolo Spina; Sergio Gentilli
      Abstract: Summary Background Paraganglioma is a rare type of neuroendocrine tumor with the ability of neuropeptide and catecholamine secretion. The most common locations of these neoplasms are head and neck regions, retroperitoneal para-aortic and paracaval, renal, and urinary bladder sympathetic plexuses; abdominal paragangliomas at other sites are extremely uncommon. Case presentation A 66-year-old male patient was admitted to our institution with a diagnosis of an infundibular pericholecystic mass. Laparoscopic cholecystectomy and pericholecystic mass radical exeresis was performed; histology achieved a diagnosis of paraganglioma located in Calot’s triangle. Conclusion The report shows an extremely rare case of an extra-adrenal abdominal paraganglioma, successfully managed with a laparoscopic approach.
      PubDate: 2017-09-04
      DOI: 10.1007/s10353-017-0488-7
  • A rare but life-threatening complication of aortic surgery: iliac
           appendiceal fistula
    • Authors: Andrea Bondurri; Lorenza Zampino
      Abstract: Summary Aortoenteric fistulas are rare (<1%) but disastrous complications after open and endovascular aortic surgery. The most frequently involved anatomical sites are abdominal aorta and duodenum. Surgery is the only possible treatment and consists, in most of cases, in an axillobifemoral bypass, a very invasive procedure with a high rate of complications. In the literature, less than 10 cases of direct communication between the right iliac artery and the appendix are described. In this paper, we discuss our experience of a case of iliac appendiceal fistula. We go through clinical presentation, diagnostic path and treatment with a brief look at the literature. Our conclusion is that in some cases a less invasive surgical approach could lead to good results, but the long-term outcomes need to be studied. Iliac appendiceal fistulas are rare variations of aortoenteric fistulas with similar onset. In cases like ours, a less invasive surgical approach could lead to good results.
      PubDate: 2017-07-18
      DOI: 10.1007/s10353-017-0486-9
  • Dual-port vs. single-port laparoscopic colectomy for colon cancer
    • Authors: Jin Yong Shin
      Abstract: Summary Background Dual-port laparoscopic colectomy (DPLC) has emerged as a surgical option that can overcome the technical limitations of single-port laparoscopic colectomy (SPLC). The aim of this study was to compare perioperative outcomes of DPLC and SPLC for colon cancer. Patients and methods This case-control study assessed 119 patients who underwent colon cancer surgery using DPLC (n = 66) and SPLC (n = 53). Results Propensity score matching resulted in 42 pairs of patients, equivalent in distribution of TNM stage and tumor size. Perioperative outcomes and postoperative complications were similar in the two groups, except for a tendency toward less blood loss in the DPLC group (50 ml vs. 100 ml, p = 0.087). Umbilical incision sites were significantly more common in the DPLC than in the SPLC group with left-sided colon cancer (94.4% vs. 66.7%, p = 0.032). In a subgroup of patients with stage II–IV tumors, there were no significant between-group differences in perioperative outcomes. Conclusion These findings show that perioperative outcomes following colon cancer surgery with DPLC were not superior to those achieved with SPLC. DPLC may be associated with better cosmetic outcomes through greater use of an umbilical approach for left-sided colectomies.
      PubDate: 2017-07-14
      DOI: 10.1007/s10353-017-0482-0
  • Does BMI affect the detection of sentinel lymph nodes with indocyanine
           green in early breast cancer patients?
    • Authors: Stephanie Rauch; Anton Haid; Zerina Jasarevic; Christoph H. Saely; Alexander Becherer; Etienne Wenzl
      Abstract: Summary Background Sentinel node biopsy (SNB) has proved to be a useful and safe method for axillary staging in the surgical management of early breast cancer. Sentinel node (SN) detection rates with blue dye (patent blue) and radioisotopes (99m-Tc), either alone or particularly in combination, are high (95% to 100%). Even better detection rates were reported with fluorescent dyes like indocyanine green (ICG). This study was designed to show whether sentinel node detection and mapping of lymphatics with ICG might depend on the body mass index (BMI). Methods Between February 2014 and April 2015, SNB with blue dye, 99m-Tc, and ICG navigation was conducted for 100 consecutive procedures in patients scheduled for surgery of early breast cancer. ICG injection, lymphatic mapping with the Photodynamic Eye (PDE; Hamamatsu Photonics, Hamamatsu, Japan), and identification of the sentinel nodes with blue dye and ICG were followed by a final search for more lymph nodes with a gamma probe. Data were collected prospectively. Results In all patients, up to six sentinel nodes (mean 2.49) were detected. No statistical correlation was found between the BMI and the identification of lymphatics or the detection of lymph nodes with ICG. Lymphatics were successfully identified preoperatively in no more than 79 cases. In 6 patients, a gamma probe was needed for detection. Adverse events or allergic reactions were absent throughout. Conclusions SN detection and lymphatic mapping with ICG were not related to the BMI. Pending answers to as yet unsolved questions, the combined use of blue dye and 99m-Tc imaging should, however, be continued.
      PubDate: 2017-06-09
      DOI: 10.1007/s10353-017-0480-2
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
Home (Search)
Subjects A-Z
Publishers A-Z
Your IP address:
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-2016