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Publisher: Springer-Verlag   (Total: 2336 journals)

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Showing 1201 - 1400 of 2336 Journals sorted alphabetically
J. of Community Genetics     Hybrid Journal   (Followers: 1, SJR: 0.727, h-index: 14)
J. of Community Health     Hybrid Journal   (Followers: 8, SJR: 0.921, h-index: 44)
J. of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology     Hybrid Journal   (Followers: 7, SJR: 1.087, h-index: 74)
J. of Comparative Physiology B : Biochemical, Systemic, and Environmental Physiology     Hybrid Journal   (Followers: 4, SJR: 1.126, h-index: 59)
J. of Compassionate Health Care     Open Access   (Followers: 1)
J. of Computational Analysis and Applications     Hybrid Journal   (SJR: 0.291, h-index: 19)
J. of Computational Electronics     Hybrid Journal   (Followers: 4, SJR: 0.511, h-index: 20)
J. of Computational Neuroscience     Hybrid Journal   (Followers: 20, SJR: 1.068, h-index: 60)
J. of Computer and Systems Sciences Intl.     Hybrid Journal   (SJR: 0.27, h-index: 13)
J. of Computer Science and Technology     Open Access   (Followers: 5, SJR: 0.437, h-index: 31)
J. of Computer Virology and Hacking Techniques     Hybrid Journal   (Followers: 7, SJR: 0.151, h-index: 2)
J. of Computer-Aided Molecular Design     Hybrid Journal   (Followers: 3, SJR: 0.995, h-index: 78)
J. of Computers in Education     Hybrid Journal   (Followers: 8)
J. of Computing in Higher Education     Hybrid Journal   (Followers: 13, SJR: 0.363, h-index: 21)
J. of Consumer Policy     Hybrid Journal   (Followers: 5, SJR: 0.704, h-index: 30)
J. of Contemporary Mathematical Analysis     Hybrid Journal   (SJR: 0.237, h-index: 5)
J. of Contemporary Physics (Armenian Academy of Sciences)     Hybrid Journal   (Followers: 11, SJR: 0.197, h-index: 6)
J. of Contemporary Psychotherapy     Hybrid Journal   (Followers: 5, SJR: 0.397, h-index: 23)
J. of Control Theory and Applications     Hybrid Journal   (Followers: 2, SJR: 0.359, h-index: 19)
J. of Control, Automation and Electrical Systems     Hybrid Journal   (Followers: 7, SJR: 0.231, h-index: 9)
J. of Crop Science and Biotechnology     Hybrid Journal   (Followers: 7)
J. of Cross-Cultural Gerontology     Hybrid Journal   (Followers: 5, SJR: 0.631, h-index: 29)
J. of Cryptographic Engineering     Partially Free   (Followers: 5, SJR: 0.989, h-index: 11)
J. of Cryptology     Hybrid Journal   (Followers: 2, SJR: 1.443, h-index: 55)
J. of Cultural Economics     Hybrid Journal   (Followers: 4, SJR: 0.539, h-index: 29)
J. of Database Marketing & Customer Strategy Management     Hybrid Journal   (Followers: 8, SJR: 0.149, h-index: 8)
J. of Derivatives & Hedge Funds     Hybrid Journal   (Followers: 7, SJR: 0.114, h-index: 5)
J. of Developmental and Physical Disabilities     Hybrid Journal   (Followers: 8, SJR: 0.574, h-index: 29)
J. of Digital Imaging     Hybrid Journal   (Followers: 9, SJR: 0.578, h-index: 35)
J. of Direct Data and Digital Marketing Practice     Hybrid Journal   (Followers: 8, SJR: 0.154, h-index: 6)
J. of Dynamical and Control Systems     Hybrid Journal   (Followers: 2, SJR: 0.4, h-index: 26)
J. of Dynamics and Differential Equations     Hybrid Journal   (SJR: 1.418, h-index: 31)
J. of Earth Science     Hybrid Journal   (Followers: 8, SJR: 0.483, h-index: 16)
J. of Earth System Science     Open Access   (Followers: 43, SJR: 0.448, h-index: 32)
J. of East Asian Linguistics     Hybrid Journal   (Followers: 5, SJR: 0.537, h-index: 20)
J. of Echocardiography     Hybrid Journal   (Followers: 4, SJR: 0.22, h-index: 3)
J. of Economic Growth     Hybrid Journal   (Followers: 23, SJR: 3.273, h-index: 63)
J. of Economic Interaction and Coordination     Hybrid Journal   (SJR: 0.263, h-index: 12)
J. of Economics     Hybrid Journal   (Followers: 10, SJR: 0.418, h-index: 23)
J. of Economics and Finance     Hybrid Journal   (Followers: 6, SJR: 0.272, h-index: 19)
J. of Educational Change     Hybrid Journal   (Followers: 7, SJR: 0.961, h-index: 21)
J. of Elasticity     Hybrid Journal   (Followers: 5, SJR: 0.851, h-index: 45)
J. of Electroceramics     Hybrid Journal   (SJR: 0.577, h-index: 57)
J. of Electronic Materials     Hybrid Journal   (Followers: 3, SJR: 0.609, h-index: 75)
J. of Electronic Testing     Hybrid Journal   (Followers: 2, SJR: 0.372, h-index: 27)
J. of Electronics (China)     Hybrid Journal   (Followers: 4, SJR: 0.112, h-index: 9)
J. of Elementary Science Education     Hybrid Journal   (Followers: 8)
J. of Engineering Mathematics     Hybrid Journal   (SJR: 0.347, h-index: 37)
J. of Engineering Physics and Thermophysics     Hybrid Journal   (Followers: 1, SJR: 0.288, h-index: 11)
J. of Engineering Research     Open Access   (SJR: 0.145, h-index: 5)
J. of Engineering Thermophysics     Hybrid Journal   (Followers: 2, SJR: 0.763, h-index: 9)
J. of Environmental Studies and Sciences     Partially Free   (Followers: 2)
J. of Ethology     Hybrid Journal   (Followers: 2, SJR: 0.609, h-index: 25)
J. of Evolution Equations     Hybrid Journal   (SJR: 0.826, h-index: 26)
J. of Evolutionary Biochemistry and Physiology     Hybrid Journal   (SJR: 0.145, h-index: 11)
J. of Evolutionary Economics     Hybrid Journal   (Followers: 8, SJR: 0.492, h-index: 52)
J. of Experimental and Theoretical Physics     Hybrid Journal   (Followers: 3, SJR: 0.458, h-index: 39)
J. of Experimental Criminology     Hybrid Journal   (Followers: 40, SJR: 1.445, h-index: 28)
J. of Failure Analysis and Prevention     Hybrid Journal   (Followers: 5, SJR: 0.261, h-index: 15)
J. of Family and Economic Issues     Hybrid Journal   (Followers: 6, SJR: 0.396, h-index: 32)
J. of Family Violence     Hybrid Journal   (Followers: 31, SJR: 0.639, h-index: 56)
J. of Financial Services Marketing     Hybrid Journal   (Followers: 3, SJR: 0.273, h-index: 10)
J. of Financial Services Research     Hybrid Journal   (Followers: 16, SJR: 0.572, h-index: 36)
J. of Fixed Point Theory and Applications     Hybrid Journal   (SJR: 0.644, h-index: 13)
J. of Fluorescence     Hybrid Journal   (Followers: 3, SJR: 0.465, h-index: 56)
J. of Food Measurement and Characterization     Hybrid Journal   (SJR: 0.307, h-index: 4)
J. of Food Science and Technology     Hybrid Journal   (Followers: 5, SJR: 0.441, h-index: 29)
J. of Forest Research     Hybrid Journal   (Followers: 3, SJR: 0.495, h-index: 27)
J. of Forestry Research     Hybrid Journal   (Followers: 6, SJR: 0.304, h-index: 14)
J. of Fourier Analysis and Applications     Hybrid Journal   (Followers: 1, SJR: 1.18, h-index: 42)
J. of Friction and Wear     Hybrid Journal   (Followers: 6, SJR: 0.373, h-index: 7)
J. of Fusion Energy     Hybrid Journal   (Followers: 3, SJR: 0.387, h-index: 19)
J. of Gambling Studies     Hybrid Journal   (Followers: 4, SJR: 1.171, h-index: 57)
J. of Gastroenterology     Hybrid Journal   (Followers: 11, SJR: 1.651, h-index: 88)
J. of Gastrointestinal Cancer     Hybrid Journal   (Followers: 3, SJR: 0.304, h-index: 39)
J. of Gastrointestinal Surgery     Hybrid Journal   (Followers: 6, SJR: 1.64, h-index: 99)
J. of General Internal Medicine     Hybrid Journal   (Followers: 13, SJR: 1.804, h-index: 134)
J. of General Plant Pathology     Hybrid Journal   (SJR: 0.554, h-index: 22)
J. of Genetic Counseling     Hybrid Journal   (Followers: 5, SJR: 0.902, h-index: 39)
J. of Genetics     Open Access   (Followers: 4, SJR: 0.458, h-index: 28)
J. of Geodesy     Hybrid Journal   (Followers: 8, SJR: 2.173, h-index: 56)
J. of Geographical Sciences     Hybrid Journal   (Followers: 1, SJR: 0.8, h-index: 23)
J. of Geographical Systems     Hybrid Journal   (Followers: 3, SJR: 0.822, h-index: 39)
J. of Geometric Analysis     Hybrid Journal   (SJR: 1.491, h-index: 27)
J. of Geometry     Hybrid Journal   (Followers: 1, SJR: 0.272, h-index: 15)
J. of Global Optimization     Hybrid Journal   (Followers: 4, SJR: 0.992, h-index: 60)
J. of Global Policy and Governance     Hybrid Journal   (Followers: 8)
J. of Grid Computing     Hybrid Journal   (SJR: 1.414, h-index: 37)
J. of Hand and Microsurgery     Hybrid Journal   (Followers: 1)
J. of Happiness Studies     Hybrid Journal   (Followers: 17, SJR: 0.881, h-index: 39)
J. of Hematopathology     Hybrid Journal   (Followers: 4, SJR: 0.2, h-index: 13)
J. of Heuristics     Hybrid Journal   (Followers: 5, SJR: 1.308, h-index: 50)
J. of High Energy Physics     Hybrid Journal   (Followers: 19, SJR: 1.052, h-index: 153)
J. of Homotopy and Related Structures     Hybrid Journal   (SJR: 0.232, h-index: 2)
J. of Housing and the Built Environment     Hybrid Journal   (Followers: 6, SJR: 0.648, h-index: 28)
J. of Huazhong University of Science and Technology [Medical Sciences]     Hybrid Journal   (SJR: 0.344, h-index: 19)
J. of Ichthyology     Hybrid Journal   (Followers: 3, SJR: 0.304, h-index: 10)
J. of Immigrant and Minority Health     Hybrid Journal   (Followers: 10, SJR: 0.759, h-index: 37)
J. of Inclusion Phenomena and Macrocyclic Chemistry     Hybrid Journal   (Followers: 1, SJR: 0.331, h-index: 46)
J. of Indian Philosophy     Hybrid Journal   (Followers: 11, SJR: 0.127, h-index: 12)
J. of Indian Prosthodontic Society     Open Access   (SJR: 0.164, h-index: 7)
J. of Industrial Microbiology and Biotechnology     Hybrid Journal   (Followers: 14, SJR: 0.966, h-index: 80)
J. of Industry, Competition and Trade     Hybrid Journal   (Followers: 6, SJR: 0.327, h-index: 15)
J. of Infection and Chemotherapy     Hybrid Journal   (Followers: 1, SJR: 0.673, h-index: 46)
J. of Information Technology     Hybrid Journal   (Followers: 50, SJR: 1.474, h-index: 55)
J. of Information Technology Teaching Cases     Hybrid Journal   (Followers: 8)
J. of Infrared, Millimeter and Terahertz Waves     Hybrid Journal   (Followers: 2, SJR: 1.25, h-index: 36)
J. of Inherited Metabolic Disease     Hybrid Journal   (Followers: 2, SJR: 1.389, h-index: 77)
J. of Inorganic and Organometallic Polymers and Materials     Partially Free   (Followers: 8, SJR: 0.338, h-index: 33)
J. of Insect Behavior     Hybrid Journal   (Followers: 9, SJR: 0.569, h-index: 39)
J. of Insect Conservation     Hybrid Journal   (Followers: 10, SJR: 0.872, h-index: 43)
J. of Intelligent and Robotic Systems     Hybrid Journal   (Followers: 2, SJR: 0.629, h-index: 43)
J. of Intelligent Information Systems     Hybrid Journal   (Followers: 1, SJR: 0.691, h-index: 43)
J. of Intelligent Manufacturing     Hybrid Journal   (Followers: 4, SJR: 1.397, h-index: 54)
J. of Interventional Cardiac Electrophysiology     Hybrid Journal   (SJR: 0.93, h-index: 43)
J. of Intl. Business Studies     Hybrid Journal   (Followers: 28, SJR: 4.208, h-index: 130)
J. of Intl. Entrepreneurship     Hybrid Journal   (Followers: 9, SJR: 0.549, h-index: 23)
J. of Intl. Migration and Integration / Revue de l integration et de la migration internationale     Hybrid Journal   (Followers: 12, SJR: 0.308, h-index: 13)
J. of Intl. Relations and Development     Hybrid Journal   (Followers: 20, SJR: 0.793, h-index: 22)
J. of Labor Research     Hybrid Journal   (Followers: 17, SJR: 0.394, h-index: 27)
J. of Logic, Language and Information     Hybrid Journal   (Followers: 7, SJR: 0.288, h-index: 25)
J. of Low Temperature Physics     Hybrid Journal   (Followers: 2, SJR: 0.531, h-index: 52)
J. of Machinery Manufacture and Reliability     Hybrid Journal   (Followers: 2, SJR: 0.203, h-index: 7)
J. of Mammalian Evolution     Hybrid Journal   (Followers: 5, SJR: 1.134, h-index: 37)
J. of Mammary Gland Biology and Neoplasia     Hybrid Journal   (Followers: 1, SJR: 2.252, h-index: 83)
J. of Management and Governance     Hybrid Journal   (Followers: 12, SJR: 0.805, h-index: 33)
J. of Management Control     Hybrid Journal   (Followers: 4, SJR: 0.605, h-index: 6)
J. of Marine Science and Application     Hybrid Journal   (Followers: 3, SJR: 0.439, h-index: 11)
J. of Marine Science and Technology     Hybrid Journal   (Followers: 3, SJR: 0.235, h-index: 19)
J. of Maritime Archaeology     Hybrid Journal   (Followers: 21, SJR: 0.228, h-index: 8)
J. of Market-Focused Management     Hybrid Journal   (Followers: 2)
J. of Marketing Analytics     Hybrid Journal   (Followers: 3)
J. of Material Cycles and Waste Management     Hybrid Journal   (Followers: 3, SJR: 0.449, h-index: 22)
J. of Materials Engineering and Performance     Hybrid Journal   (Followers: 22, SJR: 0.544, h-index: 40)
J. of Materials Science     Hybrid Journal   (Followers: 19, SJR: 0.836, h-index: 123)
J. of Materials Science : Materials in Electronics     Hybrid Journal   (Followers: 3)
J. of Materials Science : Materials in Medicine     Hybrid Journal   (Followers: 5)
J. of Mathematical Biology     Hybrid Journal   (Followers: 12, SJR: 1.011, h-index: 71)
J. of Mathematical Chemistry     Hybrid Journal   (Followers: 5, SJR: 0.497, h-index: 45)
J. of Mathematical Fluid Mechanics     Hybrid Journal   (Followers: 6, SJR: 1.22, h-index: 22)
J. of Mathematical Imaging and Vision     Hybrid Journal   (Followers: 3, SJR: 0.901, h-index: 53)
J. of Mathematical Modelling and Algorithms     Hybrid Journal   (Followers: 2, SJR: 0.414, h-index: 23)
J. of Mathematical Sciences     Hybrid Journal   (SJR: 0.272, h-index: 23)
J. of Mathematics Teacher Education     Hybrid Journal   (Followers: 13, SJR: 1.062, h-index: 20)
J. of Maxillofacial and Oral Surgery     Hybrid Journal   (Followers: 1)
J. of Mechanical Science and Technology     Hybrid Journal   (Followers: 5, SJR: 0.589, h-index: 26)
J. of Medical and Biological Engineering     Hybrid Journal   (Followers: 1, SJR: 0.387, h-index: 18)
J. of Medical Humanities     Hybrid Journal   (Followers: 20, SJR: 0.299, h-index: 18)
J. of Medical Systems     Hybrid Journal   (Followers: 1, SJR: 0.717, h-index: 44)
J. of Medical Toxicology     Hybrid Journal   (Followers: 4, SJR: 0.874, h-index: 28)
J. of Medical Ultrasonics     Hybrid Journal   (Followers: 2, SJR: 0.18, h-index: 13)
J. of Medicine and the Person     Hybrid Journal  
J. of Membrane Biology     Hybrid Journal   (Followers: 2, SJR: 0.738, h-index: 82)
J. of Micro-Bio Robotics     Hybrid Journal   (SJR: 0.28, h-index: 3)
J. of Microbiology     Hybrid Journal   (Followers: 7, SJR: 0.741, h-index: 43)
J. of Mining Science     Hybrid Journal   (Followers: 5, SJR: 0.317, h-index: 16)
J. of Molecular Evolution     Hybrid Journal   (Followers: 9, SJR: 0.952, h-index: 108)
J. of Molecular Histology     Hybrid Journal   (Followers: 2, SJR: 0.755, h-index: 48)
J. of Molecular Medicine     Hybrid Journal   (Followers: 15, SJR: 2.165, h-index: 113)
J. of Molecular Modeling     Hybrid Journal   (Followers: 4, SJR: 0.466, h-index: 50)
J. of Molecular Neuroscience     Partially Free   (Followers: 10, SJR: 0.988, h-index: 69)
J. of Mountain Science     Hybrid Journal   (Followers: 3, SJR: 0.418, h-index: 15)
J. of Muscle Research and Cell Motility     Hybrid Journal   (Followers: 1, SJR: 1.264, h-index: 55)
J. of Nanoparticle Research     Hybrid Journal   (Followers: 4, SJR: 0.583, h-index: 84)
J. of Natural Medicines     Hybrid Journal   (SJR: 0.602, h-index: 28)
J. of Near-Death Studies     Hybrid Journal   (Followers: 2)
J. of Nephrology     Hybrid Journal   (Followers: 5, SJR: 0.689, h-index: 55)
J. of Network and Systems Management     Hybrid Journal   (SJR: 0.466, h-index: 26)
J. of Neural Transmission     Hybrid Journal   (Followers: 2, SJR: 1.034, h-index: 86)
J. of Neuro-Oncology     Hybrid Journal   (Followers: 4, SJR: 1.274, h-index: 90)
J. of Neuroimmune Pharmacology     Hybrid Journal   (Followers: 1, SJR: 1.662, h-index: 45)
J. of Neurology     Hybrid Journal   (Followers: 13, SJR: 1.429, h-index: 105)
J. of NeuroVirology     Hybrid Journal   (Followers: 1, SJR: 0.979, h-index: 69)
J. of Nondestructive Evaluation     Hybrid Journal   (Followers: 9, SJR: 0.863, h-index: 27)
J. of Nonlinear Science     Hybrid Journal   (Followers: 1, SJR: 1.887, h-index: 42)
J. of Nonverbal Behavior     Hybrid Journal   (Followers: 4, SJR: 0.723, h-index: 47)
J. of Nuclear Cardiology     Hybrid Journal   (SJR: 1.024, h-index: 68)
J. of Nutrition, Health and Aging     Hybrid Journal   (Followers: 19, SJR: 0.919, h-index: 60)
J. of Obstetrics and Gynecology of India     Hybrid Journal   (Followers: 6, SJR: 0.214, h-index: 6)
J. of Occupational Rehabilitation     Hybrid Journal   (Followers: 15, SJR: 0.811, h-index: 51)
J. of Ocean Engineering and Marine Energy     Hybrid Journal   (Followers: 1)
J. of Ocean University of China (English Edition)     Hybrid Journal   (Followers: 1, SJR: 0.237, h-index: 11)
J. of Oceanography     Hybrid Journal   (Followers: 10, SJR: 0.796, h-index: 52)
J. of Ocular Biology, Diseases, and Informatics     Hybrid Journal   (SJR: 0.183, h-index: 11)
J. of Optical and Fiber Communications Reports     Hybrid Journal   (Followers: 3)
J. of Optics     Hybrid Journal   (Followers: 8, SJR: 0.214, h-index: 8)
J. of Optimization Theory and Applications     Hybrid Journal   (Followers: 3, SJR: 0.898, h-index: 65)
J. of Ornithology     Hybrid Journal   (Followers: 21)
J. of Orofacial Orthopedics / Fortschritte der Kieferorthopädie     Hybrid Journal   (SJR: 0.574, h-index: 33)
J. of Orthopaedic Science     Hybrid Journal   (Followers: 5, SJR: 0.708, h-index: 48)
J. of Paleolimnology     Hybrid Journal   (Followers: 5, SJR: 0.984, h-index: 64)
J. of Parasitic Diseases     Hybrid Journal   (Followers: 2, SJR: 0.298, h-index: 9)
J. of Pediatric Neuropsychology     Hybrid Journal   (Followers: 3)
J. of Pest Science     Hybrid Journal   (Followers: 2, SJR: 1.341, h-index: 28)
J. of Pharmaceutical Health Care and Sciences     Open Access  
J. of Pharmaceutical Innovation     Hybrid Journal   (Followers: 8, SJR: 0.524, h-index: 17)
J. of Pharmaceutical Investigation     Hybrid Journal   (Followers: 1, SJR: 0.331, h-index: 6)
J. of Pharmacokinetics and Pharmacodynamics     Hybrid Journal   (Followers: 18, SJR: 0.708, h-index: 46)
J. of Phase Equilibria and Diffusion     Hybrid Journal   (Followers: 18, SJR: 0.433, h-index: 36)
J. of Philosophical Logic     Hybrid Journal   (Followers: 8, SJR: 0.704, h-index: 26)

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Journal Cover European Surgery
  [SJR: 0.171]   [H-I: 15]   [5 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1682-4016 - ISSN (Online) 1682-8631
   Published by Springer-Verlag Homepage  [2336 journals]
  • Surgical use of fibrin glue-coated collagen patch for non-hemostatic
           indications
    • Authors: Dimitrios Sampanis; Maria Siori
      Pages: 262 - 268
      Abstract: Summary TachoSil and its predecessor products, TachoComb and TachoComb H, have been extensively used in a variety of multidisciplinary surgical settings since being introduced in the early 1990s. However, to date, TachoSil remains the first and only dual action patch for general tissue sealing and is frequently used in variety of surgical indications other than haemostasis. Classically, TachoSil is indicated for improvement of haemostasis. However, there is recently some evidence suggesting that it can be successfully used in promoting tissue healing, which could be useful in various non-hemostatic indications. TachoSil is safe and well tolerated, with occurrence of adverse events similar in TachoSil and non-TachoSil treated patients in controlled trials. The clinical implications of such an approach are obvious. Despite its cost, potential benefits could easily translate into cost savings due to avoidance of complications and to reduction of duration of hospital stay. Existing data are limited and further randomized controlled studies are needed to accurately establish the role of TachoSil for non-hemostatic indications in a variety of surgical indications, such as in abdominal and gastrointestinal surgery, pulmonary surgery, cardiothoracic surgery, renal surgery, gynecology, neurosurgery and more.
      PubDate: 2016-10-01
      DOI: 10.1007/s10353-016-0436-y
      Issue No: Vol. 48, No. 5 (2016)
       
  • Cleft lift versus standard excision with primary midline closure for the
           treatment of pilonidal disease. A snapshot of worldwide current practice
    • Authors: F. Guerra; G. Giuliani; S. Amore Bonapasta; D. Coletta; F. La Torre
      Pages: 269 - 272
      Abstract: Summary Background Several surgeries are available to treat pilonidal disease. Methods We analysed the relative effects of conventional excision with primary midline closure compared with the cleft lift procedure on the clinical outcomes of recent published reports. Results A total of 14 studies containing 2089 patients were included in the analysis. At pooled analysis of available data, the cleft lift procedure showed significantly lower rate of recurrence, shorter time to complete wound healing and faster return to daily activities. Conclusions The quality of available inherent evidence is not sufficient to draw definitive conclusions. Although the clinical heterogeneity among studies represents a valid concern, the quantitative synthesis of the recent literature seems to support the use of the cleft lift over conventional excision with primary midline closure.
      PubDate: 2016-10-01
      DOI: 10.1007/s10353-015-0375-z
      Issue No: Vol. 48, No. 5 (2016)
       
  • Targeted therapy in gastric cancer
    • Authors: G. Jomrich; S. F. Schoppmann
      Pages: 278 - 284
      Abstract: Summary Background Gastric cancer is the fourth most common cancer worldwide. Surgery in combination with multimodal therapy provides the only curative therapy until now. The importance of targeted therapy became clear over the last few years. Due to the implication of HER2 and angiogenesis-directed targeted therapies major advances in the treatment of gastric cancer could be reached. Nevertheless, benefits in survival remain unsatisfactory and the development of resistance to monoclonal antibodies is arising. Methods A comprehensive and comparative literature research was performed to evaluate the status of HER2 and angiogenesis-directed targeted therapy in gastric cancer. Results Up to now, trastuzumab and ramucirumab are the only agents showing remarkable benefits in the therapy for the patients suffering from gastric cancer. The limitations of targeted therapies in gastric cancer are mainly associated with the development of secondary resistance. Conclusion Addition of targeted therapy in second-line treatment is beneficial when compared with chemotherapy alone. Nevertheless, results in first-line treatment remain modest. Therefore, new therapeutic agents and combinations in the first-line treatment of gastric cancer are urgently needed and remain to be validated in clinical trials.
      PubDate: 2016-10-01
      DOI: 10.1007/s10353-016-0389-1
      Issue No: Vol. 48, No. 5 (2016)
       
  • Role of needle core biopsy in patients presenting with a breast lump
           associated with trauma
    • Authors: M. A. Parvaiz; C. Richardson; B. Isgar
      Pages: 285 - 289
      Abstract: Summary Background Patients often present to the breast clinic with a lump following trauma to the breast. Routinely, triple assessment is performed on such patients. We investigated whether a proportion of them can be safely diagnosed on the basis of clinical and radiological assessment without the need for histological confirmation. Methods We prospectively assessed all patients with a history of trauma presenting to the breast clinic over a 5-year period. Results We included 135 patients, constituting 1 % of total patients seen. They were divided into two groups for analysis. Group A included patients with trauma-related pathologies (n = 70, 52 %), comprising 47 haematomas and 23 fat necrosis. This group had a higher proportion of anti-coagulant usage (20/70). Owing to concordant clinical and radiological benign features, core biopsy was only carried out in 16 cases (23 %). All patients in this group were followed up to confirm clinical and radiological resolution of findings with no case of delayed cancer diagnosis. Group B included patients with incidental pathologies (n = 65, 48 %), consisting of 23 cancers and 42 benign lesions. Comparatively fewer patients (13/65) were on anti-coagulants. They had a history of minimal trauma and mostly no bruising, but found a lump on self-examination. The 23 cancer patients in this group had prompt triple assessment and no delay in cancer treatment. Conclusion Triple assessment is vital in patients with suspicious clinical or radiological breast lesions. However, a core biopsy can be avoided in patients with a clear history of trauma with concordant clinical and radiological features and follow-up confirming complete resolution of findings.
      PubDate: 2016-10-01
      DOI: 10.1007/s10353-016-0425-1
      Issue No: Vol. 48, No. 5 (2016)
       
  • Hepatic hydatid cysts
    • Authors: Hayder Hussein Ibrahim
      Pages: 290 - 295
      Abstract: Summary Background Hepatic hydatid cystic disease continues to be a serious health problem and is endemic in Iraq. There are of two types of cysts: noncomplicated and complicated cysts. Open surgery is widely practiced for both types. The aim of this study was to evaluate the clinical features, management, and outcome of surgical treatment in both types of cyst. Methods The study included 150 patients operated on between 1996 and 2014. The patients’ demographic data, location, number, size, type of cysts, surgical procedure performed, morbidity, recurrences, and duration of hospital stay were recorded. Results There were 102 female and 48 male patients with an age range of 4–70 years. There were more patients with noncomplicated cysts than complicated cysts – 94 and 56 patients, respectively. The complicated disease group had significantly more pronounced clinical presentations (p < 0.001) and higher postoperative morbidity (p < 0.001), and without significant change in recurrence rate (p = 0.059). Mean postoperative hospitalization time for noncomplicated cysts was 3.2 days, and for complicated cysts 5.6 days (p < 0.001). Conclusion The most common type of hydatid cyst is the noncomplicated type, which has lower complication rates and shorter hospital stay regardless of the management technique of the cyst cavity. Therefore, complicated and noncomplicated cysts should be considered as different forms of the disease entity with different outcomes.
      PubDate: 2016-10-01
      DOI: 10.1007/s10353-016-0431-3
      Issue No: Vol. 48, No. 5 (2016)
       
  • Anatomic Variations of Biliary Ducts: Magnetic Resonance
           Cholangiopancreatography Findings of 1041 Consecutive Patients
    • Authors: M. Adatepe; Z. H. Adibelli; O. S. Esen; C. Imamoglu; M. Yildirim; N. Erkan
      Pages: 296 - 303
      Abstract: Background It is important for surgical purposes to know the biliary tract anatomy and its variations in detail. The aim of the study was to evaluate the frequency of anatomical variations of the biliary tract at hepatic bifurcation level and also at cystic duct level using magnetic resonance cholangiopancreatography (MRCP). Methods A total of 1041 patients (between 16 and 102 years of age, 600 women 441 men with mean age of 60.6) were included in the study. The MRCP imaging was carried out with a 1.5 Tesla magnetic resonance imaging (MRI) device by using heavily T2-weighted sequences. Results Among the 1041 patients included in the study, 424 (40.7 %) showed anatomical variations at different levels of the biliary tree, and 12 of these patients (1.15 %) had two anatomical variations. Typical anatomy was present in 57.2 % of the females and 62.1 % males. The highest incidence of variation at the level of bifurcation was trifurcation with 133 patients (12.8 %) and at the level of cystic duct was the medial cystic duct insertion with 56 patients (5.37 %). Conclusions Trifurcation and medial cystic duct insertion seem to be more frequent in females compared to males. It is necessary to have the knowledge of these variations to avoid possible complications and also help to achieve the most effective result. MRCP is a helpful and noninvasive technique of diagnosing bile duct variations; a preoperative description of these variations may prevent various surgical complications, and we recommend a routine preoperative MRCP especially before laparoscopic cholecystectomy, liver resection surgery and liver transplant surgery.
      PubDate: 2016-10-01
      DOI: 10.1007/s10353-016-0393-5
      Issue No: Vol. 48, No. 5 (2016)
       
  • Video-assisted mediastinoscopic removal of ectopic parathyroid adenoma
           combined with standard cervical exploration
    • Authors: Petr Libánský; Danylo Yershov; Svatopluk Adámek; Jan Šimonek; Martina Fialová; Jozef Kubinyi; Robert Lischke
      Pages: 315 - 317
      Abstract: Summary Background Primary hyperparathyroidism (HPT) is one of the most common endocrine disorders. The standard treatment is surgical removal via a cervical incision. In rare cases, abnormal parathyroid tissue may be present in the mediastinum and therefore inaccessible through the standard incision. Case report A 57-year-old female presented in our clinic with high ionized calcium and high parathyroid hormone levels. A technetium-99m sestamibi scan showed a focal mass in the superior mediastinum. A single-stage cervical exploration and video-assisted mediastinoscopic (VAM) removal of the intrathoracic ectopic parathyroid adenoma was performed. Results Our approach proved to be successful. There were no surgical complications and the patient was discharged on postoperative day 2. Conclusion We suggest that in the case of occult mediastinal hyperfunctioning parathyroid tissue, a VAM is a valuable extension of the standard explorative neck surgery.
      PubDate: 2016-10-01
      DOI: 10.1007/s10353-016-0413-5
      Issue No: Vol. 48, No. 5 (2016)
       
  • Personalized treatment of breast cancer
    • Authors: Hubert Hauser
      Pages: 320 - 321
      PubDate: 2016-10-07
      DOI: 10.1007/s10353-016-0444-y
      Issue No: Vol. 48, No. 5 (2016)
       
  • Bariatrische Eingriffe in der Therapie des Diabetes mellitus Typ II
    • Authors: Stephan Kriwanek; Nada Loibner; Philipp Patri; Mathias Hofmann
      Abstract: Zusammenfassung Mithilfe bariatrischer Eingriffe kann der adipositasassoziierte Diabetes mellitus Typ II günstig beeinflusst werden. Der antidiabetische Effekt ist durch eine Erhöhung der Insulinsensitivität bedingt. Ausmaß und Dauer der Remission hängen wesentlich von dem Schweregrad und der Dauer des Diabetes zum Zeitpunkt der Operation ab. Am meisten profitieren adipöse Patientinnen und Patienten mit einem Prädiabetes. Bariatrische Eingriffe sind bei massiv adipösen Diabetikern wirksamer als nichtoperative Verfahren.
      PubDate: 2016-11-28
      DOI: 10.1007/s10353-016-0446-9
       
  • Effect of different doses of 2‑aminoethoxydiphenyl borate on intestinal
           ischemia-reperfusion injury
    • Authors: Murat Basbug; Murat Yildar; İsmail Yaman; Faruk Cavdar; Ömer Faruk Özkan; Hasan Aksit; Musa Ozgür Ozyigit; Figen Aslan; Hayrullah Derici
      Abstract: Summary Background Acute mesenteric ischemia is a life-threatening clinical entity. 2‑Aminoethoxydiphenyl borate (2-APB) is a membrane-permeable modulator of intracellular inositol triphosphate-induced calcium release. We investigated the effects of different 2‑APB doses on intestinal ischemia-reperfusion injury in an experimental rat model. Methods We divided 24 Wistar albino rats into four groups: sham, control, ischemia-reperfusion +2 mg/kg 2‑APB, and ischemia-reperfusion +4 mg/kg 2‑APB. The sham group only underwent laparotomy for 1 h 30 min. A 30-min period of mesenteric ischemia was induced in the control and two treatment groups, followed by 1 h of reperfusion. Before the laparotomy, 2 mg/kg and 4 mg/kg 2‑APB was administered i.v. in the treatments groups, and blood samples were collected after reperfusion. Serum levels of malondialdehyde, superoxide dismutase, glutathione, total antioxidant capacity, tumor necrosis factor (TNF)-α, and interleukin-6 were analyzed. Intestinal tissues were taken for histopathological, DNA fragmentation, and terminal deoxynucleotidyl transferase dUTP nick end labeling analyses to determine the proportion of apoptotic cells. Results 2-APB reduced serum malondialdehyde, TNF-α, and interleukin-6 levels. However, superoxide dismutase and total antioxidant capacity levels increased significantly in the 4‑mg/kg 2‑APB group (p < 0.05). The intestinal histopathological injury scores were significantly higher in the control group; these injuries were prevented in the 4‑mg/kg 2‑APB dose group. DNA damage after ischemia-perfusion decreased significantly in the 4‑mg/kg 2‑APB group compared with the control group. Conclusion 2-APB decreases oxidative stress and cell injury. Administering 4 mg/kg 2‑APB prevented ischemia-perfusion injury by diminishing histological damage.
      PubDate: 2016-11-16
      DOI: 10.1007/s10353-016-0452-y
       
  • A method for shaping a smooth gastric tube
    • Authors: Masahiro Kimura; Hideyuki Ishiguro; Tatsuya Tanaka; Kouji Mizoguchi
      Abstract: Summary Background The quality of the gastric tube commonly used for reconstruction after esophagectomy can influence postoperative progress. Moreover, formation of a gastric tube cannot generally be re-performed. To create a smooth gastric tube, various devices and two or more staplers are used; the use of two or more staplers means that an intersection exists. The intersection is inherently weak, and needs reinforcement as a potential site of leakage. Methods To verify the optimal orientation relative to the previous stapler, we experimented using the stomach of a pig. Difficulty was encountered inserting the stapler when orientation relative to the previous stapler was changed. The shape of the gastric wall and the staples after firing were observed. Results The intersection of the first and second staplers is complicated as the angle increases and the modification required to the stomach also increases. In the part that is not an intersection, almost all of the staples had a perfect form. At 0°, half of the staples had perfect forms, but the remaining half of the staples were distorted in shape. At 90°, none of the staples had perfect shape. Insertion of the stapler was easy and little modification of the stomach wall was needed with the radial stapler. Conclusion Herein we describe some to note at the time of gastric tube creation and our technique for the formation of a well-shaped gastric tube in which the unstapled intersection seems to maintain a natural curve and is not prone to leakage. The use of a radial stapler, in addition to a linear stapler, is a very useful and safe method for the formation of the gastric tube.
      PubDate: 2016-11-16
      DOI: 10.1007/s10353-016-0454-9
       
  • Erratum to: Surgical approach is superior to palliative treatment in
           oligometastatic lung cancer
    • Authors: Till Ploenes; Alberto Lopez-Pastorini; Erich Stoelben
      PubDate: 2016-11-10
      DOI: 10.1007/s10353-016-0445-x
       
  • Seasonal surgery: acting at dawn
    • PubDate: 2016-11-02
      DOI: 10.1007/s10353-016-0453-x
       
  • A novel glue device for fixation of mesh and peritoneal closure during
           laparoscopic inguinal hernia repair: short- and medium-term results
    • Authors: Bernhard Dauser; Alexander Szyszkowitz; Gerald Seitinger; René H. Fortelny; Friedrich Herbst
      Abstract: Summary Background Mesh fixation during transabdominal preperitoneal (TAPP) hernia repair should be done using nonpenetrating fixation devices in order to reduce acute and chronic pain. Beside fibrin sealant, N‑butyl cyanoacrylate (NBCA) can be applied. However, there are limited data using NBCA exclusively for fixation of mesh and closure of peritoneum following TAPP repair. We therefore studied a novel laparoscopic fixation device (LiquiBand®Fix8™ by Advanced Medical Solutions, Plymouth, UK) addressing these issues. Methods A prospective study was performed in two (different tertiary referral) centres in Austria, including patients undergoing TAPP repair between January and May 2015. The aforementioned device was used for fixation of mesh at predefined reference points (rectus muscle, pubic bone, triangle of doom, triangle of pain) and entire closure of peritoneum whenever possible. Results In a total of 34 (4 female) patients, 40 inguinal hernias were repaired using the TAPP approach. Fixation of mesh at four predefined reference points was successful using a single liquid anchor in 88.1 % (141/160). Thorough closure of peritoneum using NBCA was possible in 36 cases (90.0 %). Twice, additional suturing was done as the device clogged during this step of procedure. Finally, in another 2 patients, the attending surgeon declined using glue at all, as the sigmoid colon attached exerted too much traction. No device-related complication was recorded during 1‑year follow-up. Conclusion Nonpenetrating fixation of mesh during TAPP repair using this novel device is highly effective. In addition, closure of peritoneum using exclusively NBCA is safe and feasible according to our experience
      PubDate: 2016-10-21
      DOI: 10.1007/s10353-016-0450-0
       
  • Viability of five different pre- and intraoperative imaging methods for
           autologous breast reconstruction
    • Authors: K. F. Schrögendorfer; S. Nickl; M. Keck; D. B. Lumenta; C. Loewe; M. Gschwandtner; W. Haslik; J. Nedomansky
      Abstract: Summary Background Autologous breast reconstruction is an integral part in the treatment of breast cancer. While computed tomography angiography (CTA) is an established preoperative diagnostic tool for microsurgeons, no study has so far evaluated and compared five different imaging methods and their value for the reconstructive team. In order to determine the feasibility of each of the tools for routine or specialized diagnostic application, the methods’ efficiency and informative value were analyzed. Methods We retrospectively analyzed imaging data of 41 patients used for perforator location and assessment for regional perfusion and vessel patency in patients undergoing autologous breast reconstruction with deep inferior epigastric perforator flap (DIEP), transverse rectus abdominis muscle flap (TRAM), or transverse myocutaneous gracilis flap (TMG). Five different imaging techniques were used: hand held Doppler (HHD), CT angiography (CTA), macroscopic indocyanine green (ICG) video angiography, microscope-integrated ICG video angiography, and laser Doppler imaging (LDI). Results CTA proved to be the best tool for preoperative determination of the highly variable anatomy of the abdominal region, whereas HHD showed the same information on perforator localization with some false-positive results. Intraoperative HHD was an excellent tool for dissection and vessel patency judgment. Microscope-integrated ICG was an excellent tool to document the patency of microanastomoses. In our series, macroscopic perfusion measurement with ICG or LDI was only justified in special situations, where information on perfusion of abdominal or mastectomy flaps was required. LDI did not add any additional information. Conclusion Preoperative assessment should be performed by CTA with verification of the perforator location by HHD. Intraoperative HHD and microscope-integrated ICG contribute most toward the evaluation of vessel patency. ICG and LDI should only be used for special indications.
      PubDate: 2016-10-19
      DOI: 10.1007/s10353-016-0449-6
       
  • Cystic tumors of the pancreas
    • Authors: Thomas Sautner
      PubDate: 2016-10-11
      DOI: 10.1007/s10353-016-0448-7
       
  • Programmed death-ligand 1 expression in rectal cancer
    • Authors: G. Jomrich; G. R. Silberhumer; B. Marian; A. Beer; L. Müllauer
      Abstract: Summary Background Colorectal cancer (CRC) is the fourth most common cause of death worldwide. Approximately 30 % of all CRC occurs in the rectum. Improvements in survival rates were achieved thanks to multimodal therapy, combining surgery and chemoradiation. Nevertheless, the prognosis of patients suffering from rectal cancer (RC) remains poor. Programmed cell death protein 1 (PD-1) and its ligand programmed death ligand 1 (PD-L1) regulate tumor immune response. The aim of this study was to analyze the expression of PD-L1 in RC pre- and post-neoadjuvant therapy and evaluate PD-L1 as a biomarker and potential target for therapy. Methods In all, 29 patients with RC treated at the Medical University Vienna who received preoperative chemoradiation were retrospectively enrolled in this study. Expression of PD-L1 was investigated by immunohistochemistry with two different anti-PD-L1 antibodies. Results No PD-L1 expression on cancer cells could be observed in all 29 cases in the specimens before chemoradiation as well as in the surgical specimens after neoadjuvant therapy. In one of the two staining methods performed, five (17.24 %) post-chemoradiation cases showed faint lymphohistiocytic staining. Conclusion No expression of PD-L1 in RC cells before and after chemoradiation was found in our collective of 29 patients. Further investigations to evaluate the role of PD-L1 as a potential therapeutic target in RC are urgently needed.
      PubDate: 2016-10-07
      DOI: 10.1007/s10353-016-0447-8
       
  • Celiac artery compression of patients undergoing pancreatic surgery
           – a case series
    • Authors: A. Pötscher; F. Längle
      Abstract: Summary Background Celiac artery compression due to the median arcuate ligament is a rare but not an uncommon finding in patients undergoing pancreaticoduodenectomy (PD). Due to the interruption of the collateral pathways during surgery, celiac artery compression may be associated with fatal complications. Case reports In this paper, we present three patients with celiac artery compression undergoing PD. In the first case, celiac artery compression was recognized during surgery, but nevertheless the patient died postoperatively because of ongoing Klebsiella sepsis. In the second case, we did not recognize it during initial surgery so further complications could have been avoided. In the third case, compression was detected during PD and the postoperative course was without complications. Conclusion Preoperative abdominal CT scan should be evaluated very carefully in order to identify celiac artery compression. Otherwise absence or limitation of blood flow within the common hepatic artery (CHA) during surgery should lead surgeon to suspect presence of compression of the celiac artery.
      PubDate: 2016-09-15
      DOI: 10.1007/s10353-016-0443-z
       
  • Esophagectomy for eosinophilic esophagitis: how to avoid it
    • Authors: Alfredo J Lucendo
      Abstract: Summary Patients with eosinophilic esophagitis (EoE) can currently benefit from an evidence-based medical and dietary treatment according to knowledge accumulated from observational studies and randomized controlled trials, the results of which were summarized in several systematic reviews and meta-analyses. Surgery is relegated to solving some uncommon complications of EoE and has been exclusively applied in a handful of cases of esophageal perforation. This letter to the editor criticizes the only case of elective esophagectomy carried out in a 27-year-old male with EoE and longstanding dysphagia, which was unresponsive to obstinate endoscopy-based treatment. Despite medical and dietary treatment, strategies in EoE must still be improved and basing the clinical management of sufferers on the application of therapies with demonstrated effectiveness instead of empirical strategies is highly desirable.
      PubDate: 2016-09-08
      DOI: 10.1007/s10353-016-0441-1
       
  • Violent death and trauma in Norse mythology: a systematic reading of
           the Prose Edda
    • Authors: Antonis A. Kousoulis; Konstantinos S. Mylonas; Konstantinos P. Economopoulos
      Abstract: Summary Background This paper attempts to assess surgical knowledge presented in Norse mythology. The Prose Edda constitutes the most comprehensive source of Norse mythology. Literature and myth offer unique educational insights into life practices of previous eras, provided approached with a cautious and unbiased perspective. Methods English translations of Gylfaginning and Skáldskaparmál, texts from the Prose Edda, were systematically reviewed. International Statistical Classification of Diseases and Related Health Problems, 10th edition (ICD-10) definitions for trauma and violent death were utilized. A basic tabulation was followed for the recording of extracted data, including the chapter, characters involved and the text extract. Recorded cases were categorized by applying three distinct classifications and assessed by body part affected, cause of morbidity/mortality and character involved. Results A total of 52 cases of trauma were identified (19 cases in Gylfaginning and 33 in Skaldskaparsmal). In 27 cases of injury the afflicted body region was unspecified, but in the majority of specified cases it concerned a craniofacial trauma. 37 events were an outcome of personal assault, whereas 11 occurred during warfare. Moreover, three cases were suicides and one an accident. Critical assessment of the texts indicates that the predominant theme of Gylfaginning is the struggles of Norse Gods, whilst Skáldskaparmál tales revolve mostly around humans. Notably, a lack of allusion to medical knowledge and surgical practice is observed. Conclusion The systematic reading of the Prose Edda highlights the common theme of violence in Norse Mythology and distinguishes beheading in battle. The absence of documentation on medical practice is in accordance with the fact that Scandinavian mythological texts rarely elaborate on disease.
      PubDate: 2016-08-15
      DOI: 10.1007/s10353-016-0438-9
       
 
 
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