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Publisher: Springer-Verlag (Total: 2570 journals)

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Showing 1 - 200 of 2570 Journals sorted alphabetically
3D Printing in Medicine     Open Access   (Followers: 4)
3D Research     Hybrid Journal   (Followers: 22, SJR: 0.222, CiteScore: 1)
4OR: A Quarterly J. of Operations Research     Hybrid Journal   (Followers: 11, SJR: 0.825, CiteScore: 1)
AAPS J.     Hybrid Journal   (Followers: 29, SJR: 1.118, CiteScore: 4)
AAPS PharmSciTech     Hybrid Journal   (Followers: 8, SJR: 0.752, CiteScore: 3)
Abdominal Radiology     Hybrid Journal   (Followers: 19, SJR: 0.866, CiteScore: 2)
Abhandlungen aus dem Mathematischen Seminar der Universitat Hamburg     Hybrid Journal   (Followers: 4, SJR: 0.439, CiteScore: 0)
Academic Psychiatry     Full-text available via subscription   (Followers: 30, SJR: 0.53, CiteScore: 1)
Academic Questions     Hybrid Journal   (Followers: 9, SJR: 0.106, CiteScore: 0)
Accreditation and Quality Assurance: J. for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 33, SJR: 0.316, CiteScore: 1)
Acoustical Physics     Hybrid Journal   (Followers: 11, SJR: 0.359, CiteScore: 1)
Acoustics Australia     Hybrid Journal   (Followers: 1, SJR: 0.232, CiteScore: 1)
Acta Analytica     Hybrid Journal   (Followers: 7, SJR: 0.367, CiteScore: 0)
Acta Applicandae Mathematicae     Hybrid Journal   (Followers: 1, SJR: 0.675, CiteScore: 1)
Acta Biotheoretica     Hybrid Journal   (Followers: 3, SJR: 0.284, CiteScore: 1)
Acta Diabetologica     Hybrid Journal   (Followers: 19, SJR: 1.587, CiteScore: 3)
Acta Endoscopica     Hybrid Journal   (Followers: 1)
acta ethologica     Hybrid Journal   (Followers: 4, SJR: 0.769, CiteScore: 1)
Acta Geochimica     Hybrid Journal   (Followers: 7, SJR: 0.24, CiteScore: 1)
Acta Geodaetica et Geophysica     Hybrid Journal   (Followers: 3, SJR: 0.305, CiteScore: 1)
Acta Geophysica     Hybrid Journal   (Followers: 11, SJR: 0.312, CiteScore: 1)
Acta Geotechnica     Hybrid Journal   (Followers: 7, SJR: 1.588, CiteScore: 3)
Acta Informatica     Hybrid Journal   (Followers: 5, SJR: 0.517, CiteScore: 1)
Acta Mathematica     Hybrid Journal   (Followers: 12, SJR: 7.066, CiteScore: 3)
Acta Mathematica Hungarica     Hybrid Journal   (Followers: 2, SJR: 0.452, CiteScore: 1)
Acta Mathematica Sinica, English Series     Hybrid Journal   (Followers: 6, SJR: 0.379, CiteScore: 1)
Acta Mathematica Vietnamica     Hybrid Journal   (SJR: 0.27, CiteScore: 0)
Acta Mathematicae Applicatae Sinica, English Series     Hybrid Journal   (SJR: 0.208, CiteScore: 0)
Acta Mechanica     Hybrid Journal   (Followers: 24, SJR: 1.04, CiteScore: 2)
Acta Mechanica Sinica     Hybrid Journal   (Followers: 5, SJR: 0.607, CiteScore: 2)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 8, SJR: 0.576, CiteScore: 2)
Acta Meteorologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.638, CiteScore: 1)
Acta Neurochirurgica     Hybrid Journal   (Followers: 7, SJR: 0.822, CiteScore: 2)
Acta Neurologica Belgica     Hybrid Journal   (Followers: 2, SJR: 0.376, CiteScore: 1)
Acta Neuropathologica     Hybrid Journal   (Followers: 4, SJR: 7.589, CiteScore: 12)
Acta Oceanologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.334, CiteScore: 1)
Acta Physiologiae Plantarum     Hybrid Journal   (Followers: 4, SJR: 0.574, CiteScore: 2)
Acta Politica     Hybrid Journal   (Followers: 19, SJR: 0.605, CiteScore: 1)
Activitas Nervosa Superior     Hybrid Journal   (SJR: 0.147, CiteScore: 0)
Adaptive Human Behavior and Physiology     Hybrid Journal  
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 9, SJR: 0.103, CiteScore: 0)
ADHD Attention Deficit and Hyperactivity Disorders     Hybrid Journal   (Followers: 28, SJR: 0.72, CiteScore: 2)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 10)
Administration and Policy in Mental Health and Mental Health Services Research     Partially Free   (Followers: 19, SJR: 1.005, CiteScore: 2)
Adolescent Research Review     Hybrid Journal   (Followers: 1)
Adsorption     Hybrid Journal   (Followers: 5, SJR: 0.703, CiteScore: 2)
Advanced Composites and Hybrid Materials     Hybrid Journal  
Advanced Fiber Materials     Full-text available via subscription  
Advances in Applied Clifford Algebras     Hybrid Journal   (Followers: 4, SJR: 0.698, CiteScore: 1)
Advances in Astronautics Science and Technology     Hybrid Journal  
Advances in Atmospheric Sciences     Hybrid Journal   (Followers: 40, SJR: 0.956, CiteScore: 2)
Advances in Computational Mathematics     Hybrid Journal   (Followers: 22, SJR: 0.812, CiteScore: 1)
Advances in Contraception     Hybrid Journal   (Followers: 3)
Advances in Data Analysis and Classification     Hybrid Journal   (Followers: 58, SJR: 1.09, CiteScore: 1)
Advances in Gerontology     Partially Free   (Followers: 8, SJR: 0.144, CiteScore: 0)
Advances in Health Sciences Education     Hybrid Journal   (Followers: 35, SJR: 1.64, CiteScore: 2)
Advances in Manufacturing     Hybrid Journal   (Followers: 3, SJR: 0.475, CiteScore: 2)
Advances in Neurodevelopmental Disorders     Hybrid Journal  
Advances in Polymer Science     Hybrid Journal   (Followers: 49, SJR: 1.04, CiteScore: 3)
Advances in Therapy     Hybrid Journal   (Followers: 5, SJR: 1.075, CiteScore: 3)
Aegean Review of the Law of the Sea and Maritime Law     Hybrid Journal   (Followers: 7)
Aequationes Mathematicae     Hybrid Journal   (Followers: 2, SJR: 0.517, CiteScore: 1)
Aerobiologia     Hybrid Journal   (Followers: 4, SJR: 0.673, CiteScore: 2)
Aerosol Science and Engineering     Hybrid Journal  
Aerospace Systems     Hybrid Journal   (Followers: 1)
Aerotecnica Missili & Spazio : J. of Aerospace Science, Technologies & Systems     Hybrid Journal  
Aesthetic Plastic Surgery     Hybrid Journal   (Followers: 11, SJR: 0.825, CiteScore: 1)
African Archaeological Review     Hybrid Journal   (Followers: 21, SJR: 0.862, CiteScore: 1)
Afrika Matematika     Hybrid Journal   (Followers: 1, SJR: 0.235, CiteScore: 0)
Ageing Intl.     Hybrid Journal   (Followers: 7, SJR: 0.39, CiteScore: 1)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
Aging Clinical and Experimental Research     Hybrid Journal   (Followers: 3, SJR: 0.67, CiteScore: 2)
Agricultural Research     Hybrid Journal   (Followers: 7, SJR: 0.276, CiteScore: 1)
Agriculture and Human Values     Open Access   (Followers: 15, SJR: 1.173, CiteScore: 3)
Agroforestry Systems     Open Access   (Followers: 20, SJR: 0.663, CiteScore: 1)
Agronomy for Sustainable Development     Open Access   (Followers: 15, SJR: 1.864, CiteScore: 6)
AI & Society     Hybrid Journal   (Followers: 9, SJR: 0.227, CiteScore: 1)
AIDS and Behavior     Hybrid Journal   (Followers: 16, SJR: 1.792, CiteScore: 3)
Air Quality, Atmosphere & Health     Hybrid Journal   (Followers: 4, SJR: 0.862, CiteScore: 3)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Algebra and Logic     Hybrid Journal   (Followers: 7, SJR: 0.531, CiteScore: 0)
Algebra Universalis     Hybrid Journal   (Followers: 2, SJR: 0.583, CiteScore: 1)
Algebras and Representation Theory     Hybrid Journal   (Followers: 1, SJR: 1.095, CiteScore: 1)
Algorithmica     Hybrid Journal   (Followers: 9, SJR: 0.56, CiteScore: 1)
Allergo J.     Full-text available via subscription   (Followers: 1, SJR: 0.234, CiteScore: 0)
Allergo J. Intl.     Hybrid Journal   (Followers: 2)
Alpine Botany     Hybrid Journal   (Followers: 5, SJR: 1.11, CiteScore: 3)
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 2)
AMBIO     Hybrid Journal   (Followers: 10, SJR: 1.569, CiteScore: 4)
American J. of Cardiovascular Drugs     Hybrid Journal   (Followers: 17, SJR: 0.951, CiteScore: 3)
American J. of Community Psychology     Hybrid Journal   (Followers: 29, SJR: 1.329, CiteScore: 2)
American J. of Criminal Justice     Hybrid Journal   (Followers: 9, SJR: 0.772, CiteScore: 1)
American J. of Cultural Sociology     Hybrid Journal   (Followers: 18, SJR: 0.46, CiteScore: 1)
American J. of Dance Therapy     Hybrid Journal   (Followers: 7, SJR: 0.181, CiteScore: 0)
American J. of Potato Research     Hybrid Journal   (Followers: 3, SJR: 0.611, CiteScore: 1)
American J. of Psychoanalysis     Hybrid Journal   (Followers: 22, SJR: 0.314, CiteScore: 0)
American Sociologist     Hybrid Journal   (Followers: 16, SJR: 0.35, CiteScore: 0)
Amino Acids     Hybrid Journal   (Followers: 7, SJR: 1.135, CiteScore: 3)
AMS Review     Partially Free   (Followers: 4)
Analog Integrated Circuits and Signal Processing     Hybrid Journal   (Followers: 10, SJR: 0.211, CiteScore: 1)
Analysis and Mathematical Physics     Hybrid Journal   (Followers: 6, SJR: 0.536, CiteScore: 1)
Analysis in Theory and Applications     Hybrid Journal   (Followers: 1)
Analysis of Verbal Behavior     Hybrid Journal   (Followers: 6)
Analytical and Bioanalytical Chemistry     Hybrid Journal   (Followers: 32, SJR: 0.978, CiteScore: 3)
Anatomical Science Intl.     Hybrid Journal   (Followers: 3, SJR: 0.367, CiteScore: 1)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3, SJR: 2.177, CiteScore: 5)
Animal Cognition     Hybrid Journal   (Followers: 23, SJR: 1.389, CiteScore: 3)
Annales françaises de médecine d'urgence     Hybrid Journal   (Followers: 1, SJR: 0.192, CiteScore: 0)
Annales Henri Poincaré     Hybrid Journal   (Followers: 3, SJR: 1.097, CiteScore: 2)
Annales mathématiques du Québec     Hybrid Journal   (Followers: 4, SJR: 0.438, CiteScore: 0)
Annali dell'Universita di Ferrara     Hybrid Journal   (SJR: 0.429, CiteScore: 0)
Annali di Matematica Pura ed Applicata     Hybrid Journal   (Followers: 1, SJR: 1.197, CiteScore: 1)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 19, SJR: 1.042, CiteScore: 3)
Annals of Combinatorics     Hybrid Journal   (Followers: 4, SJR: 0.932, CiteScore: 1)
Annals of Data Science     Hybrid Journal   (Followers: 13)
Annals of Dyslexia     Hybrid Journal   (Followers: 10, SJR: 0.85, CiteScore: 2)
Annals of Finance     Hybrid Journal   (Followers: 35, SJR: 0.579, CiteScore: 1)
Annals of Forest Science     Hybrid Journal   (Followers: 7, SJR: 0.986, CiteScore: 2)
Annals of Global Analysis and Geometry     Hybrid Journal   (Followers: 1, SJR: 1.228, CiteScore: 1)
Annals of Hematology     Hybrid Journal   (Followers: 15, SJR: 1.043, CiteScore: 2)
Annals of Mathematics and Artificial Intelligence     Hybrid Journal   (Followers: 13, SJR: 0.413, CiteScore: 1)
Annals of Microbiology     Hybrid Journal   (Followers: 13, SJR: 0.479, CiteScore: 2)
Annals of Nuclear Medicine     Hybrid Journal   (Followers: 5, SJR: 0.687, CiteScore: 2)
Annals of Operations Research     Hybrid Journal   (Followers: 11, SJR: 0.943, CiteScore: 2)
Annals of Ophthalmology     Hybrid Journal   (Followers: 13)
Annals of PDE     Hybrid Journal  
Annals of Regional Science     Hybrid Journal   (Followers: 9, SJR: 0.614, CiteScore: 1)
Annals of Software Engineering     Hybrid Journal   (Followers: 13)
Annals of Solid and Structural Mechanics     Hybrid Journal   (Followers: 11, SJR: 0.239, CiteScore: 1)
Annals of Surgical Oncology     Hybrid Journal   (Followers: 15, SJR: 1.986, CiteScore: 4)
Annals of Telecommunications     Hybrid Journal   (Followers: 9, SJR: 0.223, CiteScore: 1)
Annals of the Institute of Statistical Mathematics     Hybrid Journal   (Followers: 1, SJR: 1.495, CiteScore: 1)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 5, SJR: 0.834, CiteScore: 2)
Apidologie     Hybrid Journal   (Followers: 4, SJR: 1.22, CiteScore: 3)
APOPTOSIS     Hybrid Journal   (Followers: 9, SJR: 1.424, CiteScore: 4)
Applicable Algebra in Engineering, Communication and Computing     Hybrid Journal   (Followers: 3, SJR: 0.294, CiteScore: 1)
Applications of Mathematics     Hybrid Journal   (Followers: 3, SJR: 0.602, CiteScore: 1)
Applied Biochemistry and Biotechnology     Hybrid Journal   (Followers: 44, SJR: 0.571, CiteScore: 2)
Applied Biochemistry and Microbiology     Hybrid Journal   (Followers: 19, SJR: 0.21, CiteScore: 1)
Applied Categorical Structures     Hybrid Journal   (Followers: 4, SJR: 0.49, CiteScore: 0)
Applied Composite Materials     Hybrid Journal   (Followers: 53, SJR: 0.58, CiteScore: 2)
Applied Entomology and Zoology     Partially Free   (Followers: 7, SJR: 0.422, CiteScore: 1)
Applied Geomatics     Hybrid Journal   (Followers: 3, SJR: 0.733, CiteScore: 3)
Applied Geophysics     Hybrid Journal   (Followers: 9, SJR: 0.488, CiteScore: 1)
Applied Intelligence     Hybrid Journal   (Followers: 15, SJR: 0.6, CiteScore: 2)
Applied Magnetic Resonance     Hybrid Journal   (Followers: 4, SJR: 0.319, CiteScore: 1)
Applied Mathematics & Optimization     Hybrid Journal   (Followers: 10, SJR: 0.886, CiteScore: 1)
Applied Mathematics - A J. of Chinese Universities     Hybrid Journal   (Followers: 1, SJR: 0.17, CiteScore: 0)
Applied Mathematics and Mechanics     Hybrid Journal   (Followers: 5, SJR: 0.461, CiteScore: 1)
Applied Microbiology and Biotechnology     Hybrid Journal   (Followers: 68, SJR: 1.182, CiteScore: 4)
Applied Physics A     Hybrid Journal   (Followers: 10, SJR: 0.481, CiteScore: 2)
Applied Physics B: Lasers and Optics     Hybrid Journal   (Followers: 26, SJR: 0.74, CiteScore: 2)
Applied Psychophysiology and Biofeedback     Hybrid Journal   (Followers: 8, SJR: 0.519, CiteScore: 2)
Applied Research in Quality of Life     Hybrid Journal   (Followers: 12, SJR: 0.316, CiteScore: 1)
Applied Solar Energy     Hybrid Journal   (Followers: 22, SJR: 0.225, CiteScore: 0)
Applied Spatial Analysis and Policy     Hybrid Journal   (Followers: 6, SJR: 0.542, CiteScore: 1)
Aquaculture Intl.     Hybrid Journal   (Followers: 26, SJR: 0.591, CiteScore: 2)
Aquarium Sciences and Conservation     Hybrid Journal   (Followers: 2)
Aquatic Ecology     Hybrid Journal   (Followers: 37, SJR: 0.656, CiteScore: 2)
Aquatic Geochemistry     Hybrid Journal   (Followers: 3, SJR: 0.591, CiteScore: 1)
Aquatic Sciences     Hybrid Journal   (Followers: 14, SJR: 1.109, CiteScore: 3)
Arabian J. for Science and Engineering     Hybrid Journal   (Followers: 5, SJR: 0.303, CiteScore: 1)
Arabian J. of Geosciences     Hybrid Journal   (Followers: 2, SJR: 0.319, CiteScore: 1)
Archaeological and Anthropological Sciences     Hybrid Journal   (Followers: 22, SJR: 1.052, CiteScore: 2)
Archaeologies     Hybrid Journal   (Followers: 13, SJR: 0.224, CiteScore: 0)
Archiv der Mathematik     Hybrid Journal   (Followers: 1, SJR: 0.725, CiteScore: 1)
Archival Science     Hybrid Journal   (Followers: 68, SJR: 0.745, CiteScore: 2)
Archive for History of Exact Sciences     Hybrid Journal   (Followers: 7, SJR: 0.186, CiteScore: 1)
Archive for Mathematical Logic     Hybrid Journal   (Followers: 3, SJR: 0.909, CiteScore: 1)
Archive for Rational Mechanics and Analysis     Hybrid Journal   (SJR: 3.93, CiteScore: 3)
Archive of Applied Mechanics     Hybrid Journal   (Followers: 6, SJR: 0.79, CiteScore: 2)
Archives and Museum Informatics     Hybrid Journal   (Followers: 176, SJR: 0.101, CiteScore: 0)
Archives of Computational Methods in Engineering     Hybrid Journal   (Followers: 6, SJR: 1.41, CiteScore: 5)
Archives of Dermatological Research     Hybrid Journal   (Followers: 7, SJR: 1.006, CiteScore: 2)
Archives of Environmental Contamination and Toxicology     Hybrid Journal   (Followers: 14, SJR: 0.773, CiteScore: 2)
Archives of Gynecology and Obstetrics     Hybrid Journal   (Followers: 18, SJR: 0.956, CiteScore: 2)
Archives of Microbiology     Hybrid Journal   (Followers: 10, SJR: 0.644, CiteScore: 2)
Archives of Orthopaedic and Trauma Surgery     Hybrid Journal   (Followers: 9, SJR: 1.146, CiteScore: 2)
Archives of Osteoporosis     Hybrid Journal   (Followers: 2, SJR: 0.71, CiteScore: 2)
Archives of Sexual Behavior     Hybrid Journal   (Followers: 11, SJR: 1.493, CiteScore: 3)
Archives of Toxicology     Hybrid Journal   (Followers: 18, SJR: 1.541, CiteScore: 5)
Archives of Virology     Hybrid Journal   (Followers: 5, SJR: 0.973, CiteScore: 2)
Archives of Women's Mental Health     Hybrid Journal   (Followers: 17, SJR: 1.274, CiteScore: 3)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2, SJR: 0.946, CiteScore: 3)
ArgoSpine News & J.     Hybrid Journal  
Argumentation     Hybrid Journal   (Followers: 6, SJR: 0.349, CiteScore: 1)
Arid Ecosystems     Hybrid Journal   (Followers: 3, SJR: 0.2, CiteScore: 0)
Arkiv för Matematik     Hybrid Journal   (Followers: 1, SJR: 0.766, CiteScore: 1)
arktos : The J. of Arctic Geosciences     Hybrid Journal  
Arnold Mathematical J.     Hybrid Journal   (Followers: 1, SJR: 0.355, CiteScore: 0)
Arthropod-Plant Interactions     Hybrid Journal   (Followers: 2, SJR: 0.839, CiteScore: 2)
Arthroskopie     Hybrid Journal   (Followers: 1, SJR: 0.131, CiteScore: 0)
Artificial Intelligence and Law     Hybrid Journal   (Followers: 12, SJR: 0.937, CiteScore: 2)
Artificial Intelligence Review     Hybrid Journal   (Followers: 22, SJR: 0.833, CiteScore: 4)
Artificial Life and Robotics     Hybrid Journal   (Followers: 10, SJR: 0.226, CiteScore: 0)
Asia Europe J.     Hybrid Journal   (Followers: 4, SJR: 0.504, CiteScore: 1)
Asia Pacific Education Review     Hybrid Journal   (Followers: 12, SJR: 0.479, CiteScore: 1)
Asia Pacific J. of Management     Hybrid Journal   (Followers: 17, SJR: 1.185, CiteScore: 2)

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Similar Journals
Journal Cover
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement
Journal Prestige (SJR): 0.316
Citation Impact (citeScore): 1
Number of Followers: 33  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0949-1775 - ISSN (Online) 1432-0517
Published by Springer-Verlag Homepage  [2570 journals]
  • Comparisons between reproducibility standard deviations (SD R ) derived
           from proficiency tests and from collaborative trials: mycotoxins in food
    • Abstract: Abstract Both proficiency tests and collaborative trials provide information about the reproducibility standard deviation (SDR) of reported results from interlaboratory studies. Prima facie we would expect the former to provide greater SDR values on average. Collaborative trials require the participants to use a closely defined analytical procedure, while no such restriction applies in proficiency tests. Therefore we would expect the individual biases of different measurement principles, procedures and laboratories to contribute an extra uncertainty to the results of proficiency tests. In this paper we compare the SDR statistics derived from the determination of mycotoxins in foodstuffs. Overall there was little difference between the sources, with the implication that proficiency test results could, in this application sector, be used as a benchmark for uncertainty.
      PubDate: 2019-12-02
  • First Indonesian proficiency testing using reference value from isotope
           dilution mass spectrometry method for benzoic acid, methyl paraben, and n
           -butyl paraben in sweet soy sauce
    • Abstract: Abstract Research Center for Chemistry-Indonesian Institute of Sciences (RCChem-LIPI) has successfully organized proficiency testing (PT) for the determination of benzoic acid, methyl paraben, and n-butyl paraben in sweet soy sauce. This is the first PT in Indonesia that uses reference values derived from a primary method gas chromatography–isotope dilution mass spectrometry method. Twenty participants from four economies registered in this PT. This paper presents the procedures in the preparation of the PT samples, the homogeneity and stability checks, as well as in the determination of the assigned values. The test samples were a candidate certified reference material prepared in accordance with ISO 17034 and ISO Guide 35. The performance evaluation of participants’ results was conducted in accordance with ISO 13528 by using the PROLab™ software. This paper also discusses the approaches taken in the calculation of the performance’s scores which were set according to the criterion required in homogeneity check, stability check, and limit of uncertainty.
      PubDate: 2019-12-01
  • Upgrading the Iranian national laboratory standard to conform to ISO
    • Abstract: Abstract The Reference Health Laboratory (RHL) of Iran is the national authority responsible for making policies and plans for providing quality laboratory services throughout the country. RHL composed a national laboratory standard in 2007 as the minimum mandatory quality requirements for clinical laboratories. The reference of that standard was ISO 15189:2007, with considerable modifications. It also contained many technical details from other credible references to become applicable for Iranian laboratories. Shortly afterward, complying with the national standard became a condition for renewing laboratory licenses. The success rate of license renewal in 2016 revealed that the majority of laboratories had implemented the main requirements of the standard. Therefore, we decided to upgrade the national standard and make it more compatible with ISO 15189:2012. Nevertheless, we tried to keep it comprehensible and user friendly, and adjusted it to the national regulations. To ensure that the new edition matches the local needs, all laboratory stakeholders were involved in revising the related sections. The second edition of the national laboratory standard is used as a scale for competency assessment. It follows the structure and format of the ISO 15189:2012. The content is also similar, although some explanations, examples and regulatory requirements are added to clarify or adapt it to the local condition. Here, we reviewed the process of upgrading the standard and discussed why and how we elaborated on certain sections of the international standard to make it easily understandable and facilitate its application while preserving the format and structure of the ISO 15189.
      PubDate: 2019-12-01
  • Non-carcinogenic health risk assessment of nitrate in bottled drinking
           waters sold in Iranian markets: A Monte Carlo simulation
    • Abstract: Abstract The main objective of the current research was to evaluate nitrate content in different brands of bottled drinking waters sold in Iranian markets using the available data in the literature and to assess the health risk associated with the consumption of drinking water containing this contaminant. The concentrations of nitrate in different brands of bottled waters in Iranian markets from 16 previous studies during 2010–2018 were derived and used for human health risk assessment. PubMed, Scopus, Science Direct, Web of Science, and Google Scholar and also Iranian database (Irandoc) were searched to find all published studies regarding the levels of nitrate in bottled drinking waters in Iran. The health risk assessment was estimated using chronic daily intake and hazard quotient based on the methodology suggested by the USEPA. The levels of nitrate in published studies varied considerably, ranging from 0.1 mg/L to 35.2 mg/L which were less than the regulatory limit of 45 mg/L for drinking water set by the USEPA. The ranges of CDI values for bottled waters were as follows: 5.13×10−4 mg/(kg d) – 8.38×10−1 mg/(kg d) [mean 3.93×10−1 mg/(kg d)], 1.58×10−5 mg/(kg d) – 2.58×10−2 mg/(kg d) [mean 1.21×10−2 mg/(kg d)], 1.09×10−6 mg/(kg d) – 1.78×10−3 mg/(kg d) [mean 8.33×10−4 mg/(kg d)] for men, women, and children, respectively. The results showed that health risk in all the studies was well within the safe zone (HQ < 1) during all the years, which indicates that these bottled waters do not induce non-carcinogenic risk. The order of non-carcinogenic health risks in studied groups was as: men > women > children.
      PubDate: 2019-12-01
  • Preparation of a reserpine certified reference material for calibration
           and analysis of liquid chromatography
    • Abstract: Abstract A certified reference material (CRM) for reserpine was investigated by raw material purification, qualitative analysis, quantitative analysis, homogeneity testing, stability testing, characterization, and uncertainty evaluation. The candidate reference material was prepared by recrystallization of purchased reserpine. After purification and drying, the candidate materials were enclosed in brown glass bottles. The chemical composition of the candidate reserpine reference material was confirmed by infrared spectroscopy, high-resolution mass spectrometry, and nuclear magnetic resonance. The homogeneity and stability of several sample bottles of the candidates were studied by stratified random sampling. With the cooperation of eight qualified laboratories, the purity of reserpine was analyzed by a mass balance method (including area normalization, water content, ash content and residual solvent analyses by liquid chromatography) with a certified purity mass fraction of 99.3 % and an expanded uncertainty of 0.5 % (k = 2). This reference material has been identified as a Chinese national-grade secondary CRM, which is numbered GBW(E) 090901, and is expected to be used in the calibration of instruments such as those used for liquid chromatography or method evaluations in food, medicine, environmental, and cosmetic analyses.
      PubDate: 2019-11-25
  • External quality assessment for molecular diagnostic laboratories in
           Belgium: Can we improve it'
    • Abstract: Abstract External quality assessment (EQA) is an essential part of performance monitoring for molecular laboratories. At the moment, a national law regulates participation in EQA schemes for clinical biology and pathology in Belgium. This study aimed (1) to get insights on how laboratories organize their EQA participation, (2) to poll satisfaction with the current situation (selection of EQA programs in advance by a governmental body), (3) to provide guidance for choosing the most relevant EQA provider and (4) to propose a new model for national performance monitoring. A survey was sent to Belgian laboratories performing molecular tests in the field of microbiology, hematology and pathology with (1) general questions on how they select an EQA provider and (2) their satisfaction of each provider. In total, 25 molecular laboratories [microbiology (N = 13), hematology (N = 8) and pathology (N = 4)] from 14 different hospitals completed the survey regarding their EQA organization. All three laboratory groups indicated to prefer EQA schemes using real patient materials as well as those with varying targets and concentrations. For molecular microbiology and hematology, schemes with a syndromic approach are sought. Since annual participation in EQA becomes burdensome in most laboratories, this paper also offers a risk-based strategy for determining the participation frequency. Based on the needs of Belgian laboratories, three proposals were made: (1) for the proper selection of an EQA scheme, (2) for determining the minimal participation frequency and (3) for the national organization of EQA schemes.
      PubDate: 2019-11-25
  • Food safety management systems based on ISO 22000:2018 methodology of
           hazard analysis compared to ISO 22000:2005
    • Abstract: Abstract The purpose of this study was to compare the difference of the methodologies between ISO 22000:2005 and ISO 22000:2018. Compared to the methodology of food safety management system ISO 22000:2005, the methodology of ISO 22000:2018 has not been seen yet. The methodology established in this study was based on the differences of ISO 22000:2018 and ISO 22000:2005 and the abundant experiences of author toward the counseling of verification. The high-level structural management of ISO 22000:2018 can be integrated with other management systems. The risk which was assessed through the severity and possibilities could be converted into an opportunity according to the new method of risk evaluation of ISO 22000:2018 based on the CODEX HACCP. Relatedly, through the implementation of the HACCP system, the key regulatory terms relevant for adherence to ISO 22000:2018 have been added and revised. In particular, the new regulations state that the members of food safety management committees must either possess the expertise required to determine hazards or seek the assistance of outside experts when necessary. This regulation must be effectively implemented in the FSMS of small- and medium-sized enterprises throughout the world. In addition, the key terms and definitions of ISO 22000:2018 such as critical control points, prerequisite programs, and operation prerequisite programs are more clearly defined and consistent with the standard operating procedures of effective food safety management systems. ISO 22000:2018 also pays greater attention to the two “plan, do, check, action” (PDCA) cycles including food safety management system and food safety level. These two PDCA cycles emphasize the need for independent operation but should also be implemented such that they have close synergy and harmony with each other. This methodology was used for the verification of ISO 22000:2018 of seven factories.
      PubDate: 2019-11-13
  • Assessing the performance of measurement devices for continuously
           monitoring of organic matter and nutrient in river water
    • Abstract: Abstract The evaluation of the metrological performance parameters of 27 water quality monitoring devices for continuously measuring nutrients and organic matter in river waters was conducted both under controlled conditions in the laboratory and under field conditions during a 3-month field trial. It consisted of (i) designing protocols to assess metrological performance parameters under controlled and field conditions of monitoring devices (ii) selecting a site to conduct a field trial (iii) selecting monitoring devices and (iv) conducting the testing. The results obtained for the devices measuring nitrate, total nitrogen and organic carbon are presented in this paper. The performances evaluated under controlled conditions were very acceptable with the vast majority of the monitoring devices being characterized by a repeatability below 5 %, a bias below 10 %, a linearity deviation below 10 % and a combined expanded uncertainty below 15 %. Moreover, the monitoring devices tested were found to have quantification limits suitable with regard to the concentration levels measured in the Oise River between October 2015 and February 2016. Finally, from the results obtained as well as the feedback on testing a great variety of monitoring devices, it was possible to draw some recommendations for improving the measurements using the devices tested.
      PubDate: 2019-10-30
  • Results of a proficiency testing on the calibration of clinical
           liquid-in-glass thermometer
    • Abstract: Abstract This article reports evaluation results of a proficiency testing conducted between clinical labs and Research Centre for Metrology-LIPI (RCM-LIPI), within the framework of calibration of clinical liquid-in-glass thermometer (CLIGT). RCM-LIPI is the pilot lab and has duty in the determination of reference value by linking the results to the SI-traceable National Standards. Two CLIGTs were calibrated against a standard platinum resistance thermometer in RCM-LIPI. Afterward, the CLIGTs were circulated through two calibration loops to eight labs and were calibrated at their calibration facilities using their owned routine procedure. The results show that three of the eight labs failed the comparison with En values greater than one. The article gives suggested solutions to identified measurement issues at these three labs that need attention.
      PubDate: 2019-10-30
  • The role of the CCQM OAWG in providing SI traceable calibrators for
           organic chemical measurements
    • Abstract: Abstract Metrological traceability for organic chemical measurements is a documented unbroken chain of calibrations with stated uncertainties that ideally link the measurement result for a sample to a primary calibrator in appropriate SI units (e.g., mass fraction). A comprehensive chemical purity determination of the organic calibrator is required to ensure a true assessment of this result. We explore the evolution of chemical purity capabilities across metrology institute members of the Consultative Committee for Amount of Substance: Metrology in Chemistry and Biology’s Organic Analysis Working Group (OAWG). The OAWG work program has promoted the development of robust measurement capabilities, using indirect “mass balance” determinations via rigorous assessment of impurities and direct determination using quantitative nuclear magnetic resonance spectroscopy methods. A combination of mass balance and qNMR has been shown to provide a best practice approach. Awareness of the importance of the traceability of organic calibrators continues to grow across stakeholder groups, particularly in key areas such as clinical chemistry where activities related to the Joint Committee for Traceability in Laboratory Medicine have raised the profile of traceable calibrators.
      PubDate: 2019-10-08
  • Enumeration of lactic acid bacteria: lacuna and improvement areas
           highlighted by proficiency testing
    • Abstract: Abstract During the 2011 to 2018 food microbiology proficiency testing (PT) schemes organized by REQUASUD, a systematic analytical issue was detected. For the enumeration of the lactic acid bacteria (LAB), laboratories carrying out the same analytical method (ISO 15214) yielded completely incoherent results while analysing naturally contaminated samples (raw milk, smoked salmon and ham sausage), leading to an atypically large distribution of the PT results. A comprehensive study of these atypical PT results provided insight into the source of systematic errors affecting the LAB enumeration. The main sources of analytical variability turned out to be linked to the ISO 15214:1998 standard. To better harmonize the analytical results, practical improvements can be proposed for the revision of this standard, mainly: the addition of precise criteria for the colony count, a restriction of the allowed incubation conditions and the use of a more selective culture medium (e.g. supplemented with sorbate) to limit the growth of interfering colonies. PT is a privileged observation post to highlight such analytical issues, which would otherwise remain unnoticed. Whenever an unusual distribution of PT results is observed (e.g. high dispersion or non-normal distribution of the values), it is the responsibility of the PT provider to try to identify the causes of non-normality, in a perspective of method improvement. The statistical analysis of atypical PT results requires specific attention: ignoring the non-normality of PT results when it occurs can lead to set an erroneous assigned value, unfairly penalizing participants.
      PubDate: 2019-10-01
  • Improving laboratory economic and environmental performance by the
           implementation of an environmental management system
    • Abstract: Abstract The RCPAQAP is a medium-sized healthcare organisation with a laboratory, logistics and office area. The organisation begun integrating an environmental management system as well as Lean and Business Excellence into its business practice. There have been real and tangible benefits to the organisation in terms of environmental footprint, cultural change and financial performance. There have been significant savings in waste, power and reduced paper usage. The total savings over 3 years were of the order of $800000. There has also been cultural change among the staff. The organisation has achieved accreditation to ISO 14001 and received an award from the Australian Business Excellence Awards scheme. The RCPAQAP has been able to document a process that has led to the successful integration of an EMS into business practice and has recorded real benefits from the exercise.
      PubDate: 2019-10-01
  • Compliance with good manufacturing practices for medicines in Brazil
    • Abstract: Abstract Good manufacturing practices (GMP) ensure that products are consistently produced and controlled according to appropriate quality standards. This study aimed to evaluate the GMP compliance of Brazilian medicine manufacturers over the past 3 years. The outcomes, deficiencies, and significance of these were collected from 485 inspections performed between 2015 and 2017. The nonconformities were arranged by sections of the GMP guidelines to demonstrate the main areas of deficiency. During the evaluation period, 61.4 % of inspected companies were classified as GMP ‘satisfactory’; 23.3 % were classified as ‘on hold’; and 15.3 % of inspections concluded that the company did not comply with GMP and resulted in an ‘unsatisfactory’ classification. At least one deficiency was found in 280 inspections (57.7 %). Critical deficiencies were found in 52 (10.7 %) inspections, major deficiencies were observed in 203 (41.9 %) inspections, and minor deficiencies were observed in 251 (51.8 %) inspections. The most common areas of deficiency were qualification and validation, documentation, and premises. The level of GMP compliance increased over the evaluation period. Updates or additional guidelines for the specific issues in which deficiencies are often identified might be useful to improve industry GMP compliance. The public disclosure of inspection outcomes and deficiencies may encourage the industry to comply with GMP and assist regulatory authorities in the maintenance of regulatory transparency. Knowledge of GMP noncompliance patterns and trends may allow the prioritization of inspections on high-risk areas and facilities, with the main goal of protecting the population from substandard medicines.
      PubDate: 2019-10-01
  • Direct analysis of free-base nicotine in tobacco leaf by headspace
           solid-phase micro-extraction combined with gas chromatography/mass
    • Abstract: Abstract A little nicotine in tobacco leaf is non-ionized, which is also known as free-base nicotine (FBN). The dynamic equation existed between FBN and ionized nicotine can easily change with water content, temperature and pH value. In this study, a method of the direct quantitative analysis for FBN in tobacco leaf by using headspace solid-phase micro-extraction, combined with gas chromatography/mass spectrometry, was developed. The optimum conditions for analysis method, including sample forms, SPME fiber type, pre-equilibrium temperature, pre-equilibrium time, extraction temperature and extraction time, were investigated in detail. Under the optimized conditions, the linear range of the method was 1 mg/mL–100 mg/mL, with a correlation coefficient (r) of 0.9977 and a detection limit of 0.84 μg/g, the repeatability (expressed as relative standard deviation) was 3.35 %, and the recovery of this method was between 99.56 % and 99.80 %. The uncertainty budget was finally done according to the “Guide to the Expression of Uncertainty in Measurement,” and the relative expanded uncertainty was 7.1 % with coverage factor k = 2. This method may be reliable and convenient for tobacco control.
      PubDate: 2019-10-01
  • Congresses, conferences, workshops and courses
    • PubDate: 2019-09-24
  • Modelling European quality assurance procedures for analysers monitoring
           emissions under the EU’s Industrial Emissions Directive
    • Abstract: Abstract A model has been created to investigate the uncertainty of a gas analyser operating according to the European Standard EN 14181, which ensures that the measurement uncertainty meets the requirements of legislation (Industrial Emissions Directive). This paper summarises the validation and initial results from the model, looking at the effect of varying the uncertainty of the reference method used to calibrate the analyser. The legislation allows the reference method an uncertainty of up to 20 %, but this will influence the quality of the calibration of the analyser. The results illustrate the problem and highlight that it becomes a significant issue when the reference method’s uncertainty is greater than 15 %, with the analyser failing its calibration almost half of the time due to poor reference performance at 20 % uncertainty. The model can be used to test future changes to legislation and can help operators to ensure that they would be able to meet such future measurement challenges.
      PubDate: 2019-08-19
  • Revision of ISO 19229 to support the certification of calibration gases
           for purity
    • Abstract: Abstract The second edition of ISO 19229 expands the guidance in its predecessor in two ways. Firstly, it provides more support and examples describing possible experimental approaches for purity analysis. A novelty is that it describes how the beta distribution or some other suitable probability distribution can be used to approximate the distribution of the output quantity, i.e. the fraction of a component. It also provides guidance on how to report coverage intervals in those cases, where the usual approximation from the Guide to the Expression of Uncertainty in Measurement to use the normal or t distribution is inappropriate because of vicinity of zero. Coverage intervals play an important role in conformity assessment, and it is also customary to report measurement uncertainty in the form of a coverage interval, notwithstanding that ISO/IEC 17025 does not explicitly require it. ISO 6141, which sets requirements for certificates of calibration gas mixtures, does require the statement of an expanded uncertainty, which has been interpreted that in the case of a non-symmetric output probability distribution, a coverage interval should be stated, along with the value and the standard uncertainty. This paper gives a brief background to the choices made and examples in ISO 19229.
      PubDate: 2019-08-12
  • Measurement of organochlorine pesticides in drinking water: laboratory
           technical proficiency testing in Mexico
    • Abstract: Abstract An interlaboratory comparison exercise was performed to assess the technical proficiency of laboratories in measuring the organochlorine pesticides in drinking water. The homogeneity and stability of the samples to be used in the test were evaluated, the assigned value and the standard deviation were determined according to ISO Guide 35 and ISO standard 17043, and the results showed that the samples were homogeneous and stable for the study period. The test samples (previously verified, as pesticide-free) and the fortifying solution were distributed to nine laboratories in Mexico and analyzed using their own established analytical methods. The pesticides in the fortifying solution were aldrin, β-endosulfan, heptachlor, lindane (γ-HCH), and p,p′-DDE. The assigned values and reference standard deviations were compared with those obtained by each laboratory to determine the z-score for each pesticide and laboratory, and the results are shown graphically for each pesticide. The acceptable z-scores obtained by the participating laboratories were 20 %, 20 %, 20 %, 40 %, and 16.7 % for aldrin, β-endosulfan, heptachlor, lindane, and p,p′-DDE, respectively. This study also provides a summary of the sample preparation and chromatographic techniques used by the participating laboratories, which highlights the technical problems revealed by the interlaboratory exercise.
      PubDate: 2019-08-07
  • Designing a formulation of synthetic wastewater as proficiency testing
           sample: a feasibility study on a laboratory scale
    • Abstract: Abstract Monitoring water quality is very crucial for sustainability and availability of clean water on earth. Electrolytic conductivity is one of the important water quality parameters to be monitored according to American Environmental Protection Agency, World Health Organization and Ministry of Environment and Forests Republic of Indonesia. Testing laboratories have a significant role in producing the accurate measurement related to the water quality parameters including electrolytic conductivity. Therefore, participating in a proficiency testing (PT) is mandatory, especially for the accredited testing laboratories, to demonstrate the competency of laboratories in doing the measurement. As PT provider, Chemical Metrology Laboratory held annual PT round since 2013. In 2018 PT round, the Chemical Metrology Laboratory provided a PT to measure the electrolytic conductivity of synthetic wastewater. Before preparing the PT test samples, the feasibility study was conducted to determine the best formulation of synthetic wastewater. During this study, two different formulations were compared in terms of simplicity formulation, electrolytic conductivity value, total dissolved solid/electrolytic conductivity conversion value, homogeneity and stability of the synthetic wastewater. The results show that both candidates are sufficient to be used as PT test samples; however, only one candidate was selected due to its ease and simplicity formulation.
      PubDate: 2019-08-03
  • Rounding the expanded uncertainty
    • Abstract: Abstract When reporting expanded uncertainty, rounding the number of significant figures can affect the associated level of confidence. A simple numerical method is used to measure the level of confidence obtained after different rounding methods have been applied. This also offers some insight into the meaning of level of confidence. The findings are consistent with NIST recommendations that, for a level of confidence of 95 %, an expanded uncertainty should be rounded to two significant figures and the accompanying measured value reported in the same precision.
      PubDate: 2019-07-31
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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Fax: +00 44 (0)131 4513327
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