Publisher: Springer-Verlag (Total: 2570 journals)

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Showing 1 - 200 of 2570 Journals sorted alphabetically
3D Printing in Medicine     Open Access   (Followers: 4)
3D Research     Hybrid Journal   (Followers: 21, SJR: 0.222, CiteScore: 1)
4OR: A Quarterly J. of Operations Research     Hybrid Journal   (Followers: 11, SJR: 0.825, CiteScore: 1)
AAPS J.     Hybrid Journal   (Followers: 30, SJR: 1.118, CiteScore: 4)
AAPS PharmSciTech     Hybrid Journal   (Followers: 9, SJR: 0.752, CiteScore: 3)
Abdominal Radiology     Hybrid Journal   (Followers: 20, SJR: 0.866, CiteScore: 2)
Abhandlungen aus dem Mathematischen Seminar der Universitat Hamburg     Hybrid Journal   (Followers: 4, SJR: 0.439, CiteScore: 0)
Academic Psychiatry     Full-text available via subscription   (Followers: 31, SJR: 0.53, CiteScore: 1)
Academic Questions     Hybrid Journal   (Followers: 9, SJR: 0.106, CiteScore: 0)
Accreditation and Quality Assurance: J. for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 33, SJR: 0.316, CiteScore: 1)
Acoustical Physics     Hybrid Journal   (Followers: 11, SJR: 0.359, CiteScore: 1)
Acoustics Australia     Hybrid Journal   (Followers: 1, SJR: 0.232, CiteScore: 1)
Acta Analytica     Hybrid Journal   (Followers: 7, SJR: 0.367, CiteScore: 0)
Acta Applicandae Mathematicae     Hybrid Journal   (Followers: 1, SJR: 0.675, CiteScore: 1)
Acta Biotheoretica     Hybrid Journal   (Followers: 3, SJR: 0.284, CiteScore: 1)
Acta Diabetologica     Hybrid Journal   (Followers: 19, SJR: 1.587, CiteScore: 3)
Acta Endoscopica     Hybrid Journal   (Followers: 1)
acta ethologica     Hybrid Journal   (Followers: 4, SJR: 0.769, CiteScore: 1)
Acta Geochimica     Hybrid Journal   (Followers: 7, SJR: 0.24, CiteScore: 1)
Acta Geodaetica et Geophysica     Hybrid Journal   (Followers: 3, SJR: 0.305, CiteScore: 1)
Acta Geophysica     Hybrid Journal   (Followers: 11, SJR: 0.312, CiteScore: 1)
Acta Geotechnica     Hybrid Journal   (Followers: 7, SJR: 1.588, CiteScore: 3)
Acta Informatica     Hybrid Journal   (Followers: 5, SJR: 0.517, CiteScore: 1)
Acta Mathematica     Hybrid Journal   (Followers: 12, SJR: 7.066, CiteScore: 3)
Acta Mathematica Hungarica     Hybrid Journal   (Followers: 2, SJR: 0.452, CiteScore: 1)
Acta Mathematica Sinica, English Series     Hybrid Journal   (Followers: 6, SJR: 0.379, CiteScore: 1)
Acta Mathematica Vietnamica     Hybrid Journal   (SJR: 0.27, CiteScore: 0)
Acta Mathematicae Applicatae Sinica, English Series     Hybrid Journal   (SJR: 0.208, CiteScore: 0)
Acta Mechanica     Hybrid Journal   (Followers: 25, SJR: 1.04, CiteScore: 2)
Acta Mechanica Sinica     Hybrid Journal   (Followers: 5, SJR: 0.607, CiteScore: 2)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 8, SJR: 0.576, CiteScore: 2)
Acta Meteorologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.638, CiteScore: 1)
Acta Neurochirurgica     Hybrid Journal   (Followers: 7, SJR: 0.822, CiteScore: 2)
Acta Neurologica Belgica     Hybrid Journal   (Followers: 3, SJR: 0.376, CiteScore: 1)
Acta Neuropathologica     Hybrid Journal   (Followers: 5, SJR: 7.589, CiteScore: 12)
Acta Oceanologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.334, CiteScore: 1)
Acta Physiologiae Plantarum     Hybrid Journal   (Followers: 4, SJR: 0.574, CiteScore: 2)
Acta Politica     Hybrid Journal   (Followers: 19, SJR: 0.605, CiteScore: 1)
Activitas Nervosa Superior     Hybrid Journal   (SJR: 0.147, CiteScore: 0)
Adaptive Human Behavior and Physiology     Hybrid Journal   (Followers: 1)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 9, SJR: 0.103, CiteScore: 0)
ADHD Attention Deficit and Hyperactivity Disorders     Hybrid Journal   (Followers: 28, SJR: 0.72, CiteScore: 2)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 10)
Administration and Policy in Mental Health and Mental Health Services Research     Partially Free   (Followers: 21, SJR: 1.005, CiteScore: 2)
Adolescent Research Review     Hybrid Journal   (Followers: 2)
Adsorption     Hybrid Journal   (Followers: 5, SJR: 0.703, CiteScore: 2)
Advanced Composites and Hybrid Materials     Hybrid Journal  
Advanced Fiber Materials     Full-text available via subscription  
Advances in Applied Clifford Algebras     Hybrid Journal   (Followers: 4, SJR: 0.698, CiteScore: 1)
Advances in Astronautics Science and Technology     Hybrid Journal  
Advances in Atmospheric Sciences     Hybrid Journal   (Followers: 41, SJR: 0.956, CiteScore: 2)
Advances in Computational Mathematics     Hybrid Journal   (Followers: 23, SJR: 0.812, CiteScore: 1)
Advances in Contraception     Hybrid Journal   (Followers: 3)
Advances in Data Analysis and Classification     Hybrid Journal   (Followers: 57, SJR: 1.09, CiteScore: 1)
Advances in Gerontology     Partially Free   (Followers: 8, SJR: 0.144, CiteScore: 0)
Advances in Health Sciences Education     Hybrid Journal   (Followers: 35, SJR: 1.64, CiteScore: 2)
Advances in Manufacturing     Hybrid Journal   (Followers: 3, SJR: 0.475, CiteScore: 2)
Advances in Neurodevelopmental Disorders     Hybrid Journal  
Advances in Polymer Science     Hybrid Journal   (Followers: 49, SJR: 1.04, CiteScore: 3)
Advances in Therapy     Hybrid Journal   (Followers: 5, SJR: 1.075, CiteScore: 3)
Aegean Review of the Law of the Sea and Maritime Law     Hybrid Journal   (Followers: 8)
Aequationes Mathematicae     Hybrid Journal   (Followers: 2, SJR: 0.517, CiteScore: 1)
Aerobiologia     Hybrid Journal   (Followers: 4, SJR: 0.673, CiteScore: 2)
Aerosol Science and Engineering     Hybrid Journal  
Aerospace Systems     Hybrid Journal   (Followers: 1)
Aerotecnica Missili & Spazio : J. of Aerospace Science, Technologies & Systems     Hybrid Journal  
Aesthetic Plastic Surgery     Hybrid Journal   (Followers: 11, SJR: 0.825, CiteScore: 1)
African Archaeological Review     Hybrid Journal   (Followers: 20, SJR: 0.862, CiteScore: 1)
Afrika Matematika     Hybrid Journal   (Followers: 3, SJR: 0.235, CiteScore: 0)
Ageing Intl.     Hybrid Journal   (Followers: 7, SJR: 0.39, CiteScore: 1)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
Aging Clinical and Experimental Research     Hybrid Journal   (Followers: 3, SJR: 0.67, CiteScore: 2)
Agricultural Research     Hybrid Journal   (Followers: 7, SJR: 0.276, CiteScore: 1)
Agriculture and Human Values     Open Access   (Followers: 15, SJR: 1.173, CiteScore: 3)
Agroforestry Systems     Open Access   (Followers: 20, SJR: 0.663, CiteScore: 1)
Agronomy for Sustainable Development     Open Access   (Followers: 19, SJR: 1.864, CiteScore: 6)
AI & Society     Hybrid Journal   (Followers: 9, SJR: 0.227, CiteScore: 1)
AIDS and Behavior     Hybrid Journal   (Followers: 17, SJR: 1.792, CiteScore: 3)
Air Quality, Atmosphere & Health     Hybrid Journal   (Followers: 5, SJR: 0.862, CiteScore: 3)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Algebra and Logic     Hybrid Journal   (Followers: 7, SJR: 0.531, CiteScore: 0)
Algebra Universalis     Hybrid Journal   (Followers: 2, SJR: 0.583, CiteScore: 1)
Algebras and Representation Theory     Hybrid Journal   (Followers: 1, SJR: 1.095, CiteScore: 1)
Algorithmica     Hybrid Journal   (Followers: 9, SJR: 0.56, CiteScore: 1)
Allergo J.     Full-text available via subscription   (Followers: 1, SJR: 0.234, CiteScore: 0)
Allergo J. Intl.     Hybrid Journal   (Followers: 2)
Alpine Botany     Hybrid Journal   (Followers: 5, SJR: 1.11, CiteScore: 3)
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 2)
AMBIO     Hybrid Journal   (Followers: 10, SJR: 1.569, CiteScore: 4)
American J. of Cardiovascular Drugs     Hybrid Journal   (Followers: 17, SJR: 0.951, CiteScore: 3)
American J. of Community Psychology     Hybrid Journal   (Followers: 30, SJR: 1.329, CiteScore: 2)
American J. of Criminal Justice     Hybrid Journal   (Followers: 9, SJR: 0.772, CiteScore: 1)
American J. of Cultural Sociology     Hybrid Journal   (Followers: 19, SJR: 0.46, CiteScore: 1)
American J. of Dance Therapy     Hybrid Journal   (Followers: 7, SJR: 0.181, CiteScore: 0)
American J. of Potato Research     Hybrid Journal   (Followers: 3, SJR: 0.611, CiteScore: 1)
American J. of Psychoanalysis     Hybrid Journal   (Followers: 22, SJR: 0.314, CiteScore: 0)
American Sociologist     Hybrid Journal   (Followers: 16, SJR: 0.35, CiteScore: 0)
Amino Acids     Hybrid Journal   (Followers: 7, SJR: 1.135, CiteScore: 3)
AMS Review     Partially Free   (Followers: 4)
Analog Integrated Circuits and Signal Processing     Hybrid Journal   (Followers: 11, SJR: 0.211, CiteScore: 1)
Analysis and Mathematical Physics     Hybrid Journal   (Followers: 6, SJR: 0.536, CiteScore: 1)
Analysis in Theory and Applications     Hybrid Journal   (Followers: 1)
Analysis of Verbal Behavior     Hybrid Journal   (Followers: 6)
Analytical and Bioanalytical Chemistry     Hybrid Journal   (Followers: 32, SJR: 0.978, CiteScore: 3)
Anatomical Science Intl.     Hybrid Journal   (Followers: 3, SJR: 0.367, CiteScore: 1)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3, SJR: 2.177, CiteScore: 5)
Animal Cognition     Hybrid Journal   (Followers: 23, SJR: 1.389, CiteScore: 3)
Annales françaises de médecine d'urgence     Hybrid Journal   (Followers: 1, SJR: 0.192, CiteScore: 0)
Annales Henri Poincaré     Hybrid Journal   (Followers: 3, SJR: 1.097, CiteScore: 2)
Annales mathématiques du Québec     Hybrid Journal   (Followers: 4, SJR: 0.438, CiteScore: 0)
Annali dell'Universita di Ferrara     Hybrid Journal   (SJR: 0.429, CiteScore: 0)
Annali di Matematica Pura ed Applicata     Hybrid Journal   (Followers: 1, SJR: 1.197, CiteScore: 1)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 19, SJR: 1.042, CiteScore: 3)
Annals of Combinatorics     Hybrid Journal   (Followers: 4, SJR: 0.932, CiteScore: 1)
Annals of Data Science     Hybrid Journal   (Followers: 13)
Annals of Dyslexia     Hybrid Journal   (Followers: 11, SJR: 0.85, CiteScore: 2)
Annals of Finance     Hybrid Journal   (Followers: 35, SJR: 0.579, CiteScore: 1)
Annals of Forest Science     Hybrid Journal   (Followers: 7, SJR: 0.986, CiteScore: 2)
Annals of Global Analysis and Geometry     Hybrid Journal   (Followers: 1, SJR: 1.228, CiteScore: 1)
Annals of Hematology     Hybrid Journal   (Followers: 15, SJR: 1.043, CiteScore: 2)
Annals of Mathematics and Artificial Intelligence     Hybrid Journal   (Followers: 14, SJR: 0.413, CiteScore: 1)
Annals of Microbiology     Hybrid Journal   (Followers: 13, SJR: 0.479, CiteScore: 2)
Annals of Nuclear Medicine     Hybrid Journal   (Followers: 4, SJR: 0.687, CiteScore: 2)
Annals of Operations Research     Hybrid Journal   (Followers: 11, SJR: 0.943, CiteScore: 2)
Annals of Ophthalmology     Hybrid Journal   (Followers: 14)
Annals of PDE     Hybrid Journal  
Annals of Regional Science     Hybrid Journal   (Followers: 9, SJR: 0.614, CiteScore: 1)
Annals of Software Engineering     Hybrid Journal   (Followers: 13)
Annals of Solid and Structural Mechanics     Hybrid Journal   (Followers: 11, SJR: 0.239, CiteScore: 1)
Annals of Surgical Oncology     Hybrid Journal   (Followers: 18, SJR: 1.986, CiteScore: 4)
Annals of Telecommunications     Hybrid Journal   (Followers: 9, SJR: 0.223, CiteScore: 1)
Annals of the Institute of Statistical Mathematics     Hybrid Journal   (Followers: 1, SJR: 1.495, CiteScore: 1)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 5, SJR: 0.834, CiteScore: 2)
Apidologie     Hybrid Journal   (Followers: 5, SJR: 1.22, CiteScore: 3)
APOPTOSIS     Hybrid Journal   (Followers: 9, SJR: 1.424, CiteScore: 4)
Applicable Algebra in Engineering, Communication and Computing     Hybrid Journal   (Followers: 3, SJR: 0.294, CiteScore: 1)
Applications of Mathematics     Hybrid Journal   (Followers: 3, SJR: 0.602, CiteScore: 1)
Applied Biochemistry and Biotechnology     Hybrid Journal   (Followers: 42, SJR: 0.571, CiteScore: 2)
Applied Biochemistry and Microbiology     Hybrid Journal   (Followers: 19, SJR: 0.21, CiteScore: 1)
Applied Categorical Structures     Hybrid Journal   (Followers: 4, SJR: 0.49, CiteScore: 0)
Applied Composite Materials     Hybrid Journal   (Followers: 53, SJR: 0.58, CiteScore: 2)
Applied Entomology and Zoology     Partially Free   (Followers: 7, SJR: 0.422, CiteScore: 1)
Applied Geomatics     Hybrid Journal   (Followers: 3, SJR: 0.733, CiteScore: 3)
Applied Geophysics     Hybrid Journal   (Followers: 10, SJR: 0.488, CiteScore: 1)
Applied Intelligence     Hybrid Journal   (Followers: 15, SJR: 0.6, CiteScore: 2)
Applied Magnetic Resonance     Hybrid Journal   (Followers: 4, SJR: 0.319, CiteScore: 1)
Applied Mathematics & Optimization     Hybrid Journal   (Followers: 10, SJR: 0.886, CiteScore: 1)
Applied Mathematics - A J. of Chinese Universities     Hybrid Journal   (Followers: 1, SJR: 0.17, CiteScore: 0)
Applied Mathematics and Mechanics     Hybrid Journal   (Followers: 5, SJR: 0.461, CiteScore: 1)
Applied Microbiology and Biotechnology     Hybrid Journal   (Followers: 68, SJR: 1.182, CiteScore: 4)
Applied Physics A     Hybrid Journal   (Followers: 10, SJR: 0.481, CiteScore: 2)
Applied Physics B: Lasers and Optics     Hybrid Journal   (Followers: 26, SJR: 0.74, CiteScore: 2)
Applied Psychophysiology and Biofeedback     Hybrid Journal   (Followers: 8, SJR: 0.519, CiteScore: 2)
Applied Research in Quality of Life     Hybrid Journal   (Followers: 12, SJR: 0.316, CiteScore: 1)
Applied Solar Energy     Hybrid Journal   (Followers: 22, SJR: 0.225, CiteScore: 0)
Applied Spatial Analysis and Policy     Hybrid Journal   (Followers: 6, SJR: 0.542, CiteScore: 1)
Aquaculture Intl.     Hybrid Journal   (Followers: 26, SJR: 0.591, CiteScore: 2)
Aquarium Sciences and Conservation     Hybrid Journal   (Followers: 2)
Aquatic Ecology     Hybrid Journal   (Followers: 38, SJR: 0.656, CiteScore: 2)
Aquatic Geochemistry     Hybrid Journal   (Followers: 3, SJR: 0.591, CiteScore: 1)
Aquatic Sciences     Hybrid Journal   (Followers: 14, SJR: 1.109, CiteScore: 3)
Arabian J. for Science and Engineering     Hybrid Journal   (Followers: 5, SJR: 0.303, CiteScore: 1)
Arabian J. of Geosciences     Hybrid Journal   (Followers: 2, SJR: 0.319, CiteScore: 1)
Archaeological and Anthropological Sciences     Hybrid Journal   (Followers: 22, SJR: 1.052, CiteScore: 2)
Archaeologies     Hybrid Journal   (Followers: 13, SJR: 0.224, CiteScore: 0)
Archiv der Mathematik     Hybrid Journal   (Followers: 1, SJR: 0.725, CiteScore: 1)
Archival Science     Hybrid Journal   (Followers: 70, SJR: 0.745, CiteScore: 2)
Archive for History of Exact Sciences     Hybrid Journal   (Followers: 7, SJR: 0.186, CiteScore: 1)
Archive for Mathematical Logic     Hybrid Journal   (Followers: 3, SJR: 0.909, CiteScore: 1)
Archive for Rational Mechanics and Analysis     Hybrid Journal   (SJR: 3.93, CiteScore: 3)
Archive of Applied Mechanics     Hybrid Journal   (Followers: 6, SJR: 0.79, CiteScore: 2)
Archives and Museum Informatics     Hybrid Journal   (Followers: 176, SJR: 0.101, CiteScore: 0)
Archives of Computational Methods in Engineering     Hybrid Journal   (Followers: 6, SJR: 1.41, CiteScore: 5)
Archives of Dermatological Research     Hybrid Journal   (Followers: 7, SJR: 1.006, CiteScore: 2)
Archives of Environmental Contamination and Toxicology     Hybrid Journal   (Followers: 14, SJR: 0.773, CiteScore: 2)
Archives of Gynecology and Obstetrics     Hybrid Journal   (Followers: 19, SJR: 0.956, CiteScore: 2)
Archives of Microbiology     Hybrid Journal   (Followers: 10, SJR: 0.644, CiteScore: 2)
Archives of Orthopaedic and Trauma Surgery     Hybrid Journal   (Followers: 10, SJR: 1.146, CiteScore: 2)
Archives of Osteoporosis     Hybrid Journal   (Followers: 2, SJR: 0.71, CiteScore: 2)
Archives of Sexual Behavior     Hybrid Journal   (Followers: 11, SJR: 1.493, CiteScore: 3)
Archives of Toxicology     Hybrid Journal   (Followers: 18, SJR: 1.541, CiteScore: 5)
Archives of Virology     Hybrid Journal   (Followers: 5, SJR: 0.973, CiteScore: 2)
Archives of Women's Mental Health     Hybrid Journal   (Followers: 17, SJR: 1.274, CiteScore: 3)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2, SJR: 0.946, CiteScore: 3)
ArgoSpine News & J.     Hybrid Journal  
Argumentation     Hybrid Journal   (Followers: 6, SJR: 0.349, CiteScore: 1)
Arid Ecosystems     Hybrid Journal   (Followers: 3, SJR: 0.2, CiteScore: 0)
Arkiv för Matematik     Hybrid Journal   (Followers: 1, SJR: 0.766, CiteScore: 1)
arktos : The J. of Arctic Geosciences     Hybrid Journal  
Arnold Mathematical J.     Hybrid Journal   (Followers: 1, SJR: 0.355, CiteScore: 0)
Arthropod-Plant Interactions     Hybrid Journal   (Followers: 2, SJR: 0.839, CiteScore: 2)
Arthroskopie     Hybrid Journal   (Followers: 1, SJR: 0.131, CiteScore: 0)
Artificial Intelligence and Law     Hybrid Journal   (Followers: 12, SJR: 0.937, CiteScore: 2)
Artificial Intelligence Review     Hybrid Journal   (Followers: 25, SJR: 0.833, CiteScore: 4)
Artificial Life and Robotics     Hybrid Journal   (Followers: 10, SJR: 0.226, CiteScore: 0)
Asia Europe J.     Hybrid Journal   (Followers: 4, SJR: 0.504, CiteScore: 1)
Asia Pacific Education Review     Hybrid Journal   (Followers: 12, SJR: 0.479, CiteScore: 1)
Asia Pacific J. of Management     Hybrid Journal   (Followers: 17, SJR: 1.185, CiteScore: 2)

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Similar Journals
Journal Cover
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement
Journal Prestige (SJR): 0.316
Citation Impact (citeScore): 1
Number of Followers: 33  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0949-1775 - ISSN (Online) 1432-0517
Published by Springer-Verlag Homepage  [2570 journals]
  • Short- and long-term stability of electrolytic conductivity certified
           reference materials
    • Abstract: Abstract Electrolytic conductivity is a common parameter measured within industry. Proper usage of electrolytic conductivity sensors requires the periodic calibration using solutions of known conductivity. This parameter can be disseminated through the use of certified reference materials (CRMs) produced according to ISO 17034. A part of the certification of reference materials relates to their stability both in the material they are packaged in and as a function of time, both at the short- and long-time scales. Electrolytic conductivity CRMs produced at DFM A/S are evaluated for the stability in various bottle types, and under various storage and transport conditions. Materials with nominal conductivity values between 10 mS m−1 and 10 mS m−1 are shown to be stable at short-time (~ 1 month) and long-time (expected shelf life and beyond) scales.
      PubDate: 2020-02-18
       
  • Congresses, conferences, workshops and courses
    • PubDate: 2020-02-15
       
  • A new correction for controlling family-wise error rate in multiple
           comparison studies
    • Abstract: Abstract Misleading conclusions can be drawn from multiple comparison studies if the critical p value is set as equivalent to the preselected statistical α level. This incorrect assumption is observed in many research publications where not enough attention was paid to the inflation of the critical p value as a result of increasing the number of comparisons. A new approach is proposed to control the false discovery rate for independent comparisons. The new approach renders more reliable critical p values and allows reducing the inflated values to the original preselected α level.
      PubDate: 2020-02-06
       
  • The modified G6PD deficiency screening test
    • Abstract: Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency, which involves the mutation of the G6PD gene on the X chromosome, is the most common enzyme defect in humans. G6PD produces nicotinamide adenine dinucleotide phosphate (NADPH) for red blood cell protection from oxidative stress. Oxidative stress-induced red blood cell hemolysis in G6PD-deficient patients leads to anemia, jaundice, acute renal failure, and kernicterus in newborns. Currently, the fluorescent spot test (FST) is widely used for G6PD deficiency screening. This test detects NADPH production under UV light. This study purposed to modify the G6PD deficiency screening test based on NADPH production and the ability to detect the results of the color change in the color of the reaction. Blood samples of 60 subjects were collected and screened for G6PD deficiency using FST method. All samples were tested with the modified G6PD screening test and the quantitative assay kit. The results from the modified test showed the color red for normal cases, whereas the color brown indicated G6PD deficiency cases. The cutoff value of G6PD activity detected by the quantitative method was less than 2.9 U/gHb for G6PD deficiency. The precision of this study was 100 %. The results of sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of the modified test were 100 %, 96.7 %, 100 %, and 96.7 %, respectively. The modified G6PD screening test can be used for the screening of G6PD deficiency in newborns, for support through providing more information, and for self-protection from oxidative stress.
      PubDate: 2020-02-05
       
  • How should metrology bodies treat method-defined measurands'
    • Abstract: Abstract This discussion article explores how metrology bodies should approach method-defined measurands (also called operationally defined measurands). It begins by considering the different types of measurement that can be encountered and comparing their difference qualities, before discussing in more detail method-defined measurands and the nature of their current and future treatment by the global metrology system. The discussion highlights work performed within the Consultative Committee for Amount of Substance to address what should be within the scope of the International Committee for Weights and Measures Mutual Recognition Arrangement (CIPM-MRA) when method-defined measurands are considered and also how the metrology community can contribute to ensuring stability and comparability of these measurements outside the formal scope of the CIPM-MRA.
      PubDate: 2020-02-04
       
  • Confidence intervals for robust estimates of measurement uncertainty
    • Abstract: Abstract Uncertainties arising at different stages of a measurement process can be estimated using analysis of variance (ANOVA) on duplicated measurements. In some cases, it is also desirable to calculate confidence intervals for these uncertainties. This can be achieved using probability models that assume the measurement data are normally distributed. However, it is often the case in practice that a set of otherwise normally distributed measurement values is contaminated by a small number of outlying values, which may have a disproportionate effect on the variances calculated using the ‘classical’ form of ANOVA. In this case, robust ANOVA methods are able to provide variance estimates that are much closer to the parameters of the underlying normal distributions. A method using bootstrapping to calculate confidence intervals from robust estimates of variances is proposed and evaluated and is shown to work well when the number of outlying values is small. The method has been implemented in a visual basic program.
      PubDate: 2020-02-04
       
  • Reference versus consensus values in proficiency testing of clinical
           chemistry: a statistical comparison based on laboratories results in
           Colombia
    • Abstract: Abstract Proficiency testing or external quality control provides additional means to ensure the quality of laboratory testing results. Various methods can be considered in practice to fulfill this objective. The most commonly applied are comparison of laboratory results with reference or consensus values. In this work, we study the concordance between these schemes based on the review of a large dataset corresponding to clinical chemistry proficiency testing results. The analysis is carried out by using several statistical methodologies (diagnostic tests, contingency tables, and test of hypothesis). Results indicate that the conclusions obtained from these schemes can be in some cases (several analytes) markedly different. This is possibly because some statistical assumptions to apply PT based on consensus values are violated.
      PubDate: 2020-02-03
       
  • Food safety management systems based on ISO 22000:2018 methodology of
           hazard analysis compared to ISO 22000:2005
    • Abstract: Abstract The purpose of this study was to compare the difference of the methodologies between ISO 22000:2005 and ISO 22000:2018. Compared to the methodology of food safety management system ISO 22000:2005, the methodology of ISO 22000:2018 has not been seen yet. The methodology established in this study was based on the differences of ISO 22000:2018 and ISO 22000:2005 and the abundant experiences of author toward the counseling of verification. The high-level structural management of ISO 22000:2018 can be integrated with other management systems. The risk which was assessed through the severity and possibilities could be converted into an opportunity according to the new method of risk evaluation of ISO 22000:2018 based on the CODEX HACCP. Relatedly, through the implementation of the HACCP system, the key regulatory terms relevant for adherence to ISO 22000:2018 have been added and revised. In particular, the new regulations state that the members of food safety management committees must either possess the expertise required to determine hazards or seek the assistance of outside experts when necessary. This regulation must be effectively implemented in the FSMS of small- and medium-sized enterprises throughout the world. In addition, the key terms and definitions of ISO 22000:2018 such as critical control points, prerequisite programs, and operation prerequisite programs are more clearly defined and consistent with the standard operating procedures of effective food safety management systems. ISO 22000:2018 also pays greater attention to the two “plan, do, check, action” (PDCA) cycles including food safety management system and food safety level. These two PDCA cycles emphasize the need for independent operation but should also be implemented such that they have close synergy and harmony with each other. This methodology was used for the verification of ISO 22000:2018 of seven factories.
      PubDate: 2020-02-01
       
  • Assessing the performance of measurement devices for continuously
           monitoring of organic matter and nutrient in river water
    • Abstract: Abstract The evaluation of the metrological performance parameters of 27 water quality monitoring devices for continuously measuring nutrients and organic matter in river waters was conducted both under controlled conditions in the laboratory and under field conditions during a 3-month field trial. It consisted of (i) designing protocols to assess metrological performance parameters under controlled and field conditions of monitoring devices (ii) selecting a site to conduct a field trial (iii) selecting monitoring devices and (iv) conducting the testing. The results obtained for the devices measuring nitrate, total nitrogen and organic carbon are presented in this paper. The performances evaluated under controlled conditions were very acceptable with the vast majority of the monitoring devices being characterized by a repeatability below 5 %, a bias below 10 %, a linearity deviation below 10 % and a combined expanded uncertainty below 15 %. Moreover, the monitoring devices tested were found to have quantification limits suitable with regard to the concentration levels measured in the Oise River between October 2015 and February 2016. Finally, from the results obtained as well as the feedback on testing a great variety of monitoring devices, it was possible to draw some recommendations for improving the measurements using the devices tested.
      PubDate: 2020-02-01
       
  • Results of a proficiency testing on the calibration of clinical
           liquid-in-glass thermometer
    • Abstract: Abstract This article reports evaluation results of a proficiency testing conducted between clinical labs and Research Centre for Metrology-LIPI (RCM-LIPI), within the framework of calibration of clinical liquid-in-glass thermometer (CLIGT). RCM-LIPI is the pilot lab and has duty in the determination of reference value by linking the results to the SI-traceable National Standards. Two CLIGTs were calibrated against a standard platinum resistance thermometer in RCM-LIPI. Afterward, the CLIGTs were circulated through two calibration loops to eight labs and were calibrated at their calibration facilities using their owned routine procedure. The results show that three of the eight labs failed the comparison with En values greater than one. The article gives suggested solutions to identified measurement issues at these three labs that need attention.
      PubDate: 2020-02-01
       
  • Monitoring of purity and stability of CRMs of multiclass pesticides during
           prolonged storage before and after expiration
    • Abstract: Abstract Certified reference materials (CRMs) are the backbone for qualitative and quantitative determination of pesticides in technical materials, formulations, and food matrices. However, their stringent expiry date, limited shelf life, and diminishing purity with time, limits their use beyond expiry. Stability study of 89 CRMs of multiclass pesticides, stored at − 25 °C, has been conducted to assess the purity of CRMs beyond their expiry date. It was evident that > 96 % of the CRMs remained optimally stable with respect to their observed purity even after their expiry date as per certificate of analysis. Percentage deviations in purity of expired and valid CRMs posited well below 7 % and are within ± 10 % acceptable range as recommended by the SANTE. During 2013–2017, performance of the valid and expired CRMs was evaluated through 44 z-scores obtained in 14 international and national proficiency testing programmes. All the z-scores received for 15 expired and 29 valid CRMs were found satisfactory. Inter-laboratory comparison of 6 randomly selected expired and valid CRMs was tested at three different ISO/IEC 17025 accredited laboratories and their % difference between purities ranged from − 2.35 % to + 0.95 %. It was inferred that by maintaining proper storage conditions and continuous monitoring of purity, the expired CRMs can give comparable results as valid CRMs.
      PubDate: 2020-01-01
       
  • Report on the 42nd meeting of ISO/REMCO
    • Abstract: Abstract The 42nd meeting of the Reference Material Committee of ISO, ISO/REMCO, was held in Daejeon, South Korea, from June 10 to 13, 2019, and was hosted by the Korea Research Institute of Standards and Science (KRISS). This report details and summarizes the progress with the three new work items of the committee for the development of internationally harmonized guidance for the production of reference materials in the fields of qualitative analysis, high-purity reference materials for small organic molecules and high-purity reference materials for metals and metalloids.
      PubDate: 2019-12-23
       
  • Analytical validation of tests in laboratories of anatomic pathology: a
           Belgian population-based study
    • Abstract: Abstract Laboratories of anatomic pathology have to validate each analytical test before it is implemented in daily routine. However, evidence-based guidelines regarding validation of analytical tests are limited. A 2016 survey on test validation was performed in all 77 licensed Belgian anatomic pathology laboratories in order to evaluate the implementation and to highlight the current issues of test validation in Belgian anatomic pathology laboratories. Therefore, standard operating procedures for test validation and validation reports were evaluated for the presence of predefined items. Separate validation procedures for CE/IVD-labeled, laboratory-modified and laboratory-developed tests and a description of how each performance characteristic was validated were lacking in 51 (66 %) laboratories. Moreover, only 9 (12 %) laboratories reported to have written procedures for when and how analytical tests need to be revalidated. Better results were observed regarding the description of the performance characteristics, the co-workers involved, recording and archiving of results and raw data, the content of the validation report, ongoing validation, release and implementation into daily routine. Contrary to the evaluation results of the procedures for test validation, better results for the content of the validation reports were obtained. A lack of clear and predefined objective acceptance criteria for each determined performance characteristic was the most common shortcoming observed in validation reports in Belgian anatomic pathology laboratories. In conclusion, there appears to be a need for further development of guidelines for validation and revalidation of analytical tests performed in anatomic pathology laboratories.
      PubDate: 2019-12-20
       
  • Changing the status of mmHg
    • Abstract: Abstract The new International System of Units (SI) came into force this May, and while the media and public attention are focused on the changes in the base units, there are also other changes introduced. One of them is the abolition of millimetre of mercury (mmHg). This simplifies the SI but also can cause problems to the patients which are extremely conservative user groups (although this unit is still supported by some other authoritative documents). Hence, it is necessary to increase awareness of both the medical doctor and the patients.
      PubDate: 2019-12-07
       
  • Comparisons between reproducibility standard deviations (SD R ) derived
           from proficiency tests and from collaborative trials: mycotoxins in food
    • Abstract: Abstract Both proficiency tests and collaborative trials provide information about the reproducibility standard deviation (SDR) of reported results from interlaboratory studies. Prima facie we would expect the former to provide greater SDR values on average. Collaborative trials require the participants to use a closely defined analytical procedure, while no such restriction applies in proficiency tests. Therefore we would expect the individual biases of different measurement principles, procedures and laboratories to contribute an extra uncertainty to the results of proficiency tests. In this paper we compare the SDR statistics derived from the determination of mycotoxins in foodstuffs. Overall there was little difference between the sources, with the implication that proficiency test results could, in this application sector, be used as a benchmark for uncertainty.
      PubDate: 2019-12-02
       
  • First Indonesian proficiency testing using reference value from isotope
           dilution mass spectrometry method for benzoic acid, methyl paraben, and n
           -butyl paraben in sweet soy sauce
    • Abstract: Abstract Research Center for Chemistry-Indonesian Institute of Sciences (RCChem-LIPI) has successfully organized proficiency testing (PT) for the determination of benzoic acid, methyl paraben, and n-butyl paraben in sweet soy sauce. This is the first PT in Indonesia that uses reference values derived from a primary method gas chromatography–isotope dilution mass spectrometry method. Twenty participants from four economies registered in this PT. This paper presents the procedures in the preparation of the PT samples, the homogeneity and stability checks, as well as in the determination of the assigned values. The test samples were a candidate certified reference material prepared in accordance with ISO 17034 and ISO Guide 35. The performance evaluation of participants’ results was conducted in accordance with ISO 13528 by using the PROLab™ software. This paper also discusses the approaches taken in the calculation of the performance’s scores which were set according to the criterion required in homogeneity check, stability check, and limit of uncertainty.
      PubDate: 2019-12-01
       
  • Preparation of a reserpine certified reference material for calibration
           and analysis of liquid chromatography
    • Abstract: Abstract A certified reference material (CRM) for reserpine was investigated by raw material purification, qualitative analysis, quantitative analysis, homogeneity testing, stability testing, characterization, and uncertainty evaluation. The candidate reference material was prepared by recrystallization of purchased reserpine. After purification and drying, the candidate materials were enclosed in brown glass bottles. The chemical composition of the candidate reserpine reference material was confirmed by infrared spectroscopy, high-resolution mass spectrometry, and nuclear magnetic resonance. The homogeneity and stability of several sample bottles of the candidates were studied by stratified random sampling. With the cooperation of eight qualified laboratories, the purity of reserpine was analyzed by a mass balance method (including area normalization, water content, ash content and residual solvent analyses by liquid chromatography) with a certified purity mass fraction of 99.3 % and an expanded uncertainty of 0.5 % (k = 2). This reference material has been identified as a Chinese national-grade secondary CRM, which is numbered GBW(E) 090901, and is expected to be used in the calibration of instruments such as those used for liquid chromatography or method evaluations in food, medicine, environmental, and cosmetic analyses.
      PubDate: 2019-11-25
       
  • External quality assessment for molecular diagnostic laboratories in
           Belgium: Can we improve it'
    • Abstract: Abstract External quality assessment (EQA) is an essential part of performance monitoring for molecular laboratories. At the moment, a national law regulates participation in EQA schemes for clinical biology and pathology in Belgium. This study aimed (1) to get insights on how laboratories organize their EQA participation, (2) to poll satisfaction with the current situation (selection of EQA programs in advance by a governmental body), (3) to provide guidance for choosing the most relevant EQA provider and (4) to propose a new model for national performance monitoring. A survey was sent to Belgian laboratories performing molecular tests in the field of microbiology, hematology and pathology with (1) general questions on how they select an EQA provider and (2) their satisfaction of each provider. In total, 25 molecular laboratories [microbiology (N = 13), hematology (N = 8) and pathology (N = 4)] from 14 different hospitals completed the survey regarding their EQA organization. All three laboratory groups indicated to prefer EQA schemes using real patient materials as well as those with varying targets and concentrations. For molecular microbiology and hematology, schemes with a syndromic approach are sought. Since annual participation in EQA becomes burdensome in most laboratories, this paper also offers a risk-based strategy for determining the participation frequency. Based on the needs of Belgian laboratories, three proposals were made: (1) for the proper selection of an EQA scheme, (2) for determining the minimal participation frequency and (3) for the national organization of EQA schemes.
      PubDate: 2019-11-25
       
  • The role of the CCQM OAWG in providing SI traceable calibrators for
           organic chemical measurements
    • Abstract: Abstract Metrological traceability for organic chemical measurements is a documented unbroken chain of calibrations with stated uncertainties that ideally link the measurement result for a sample to a primary calibrator in appropriate SI units (e.g., mass fraction). A comprehensive chemical purity determination of the organic calibrator is required to ensure a true assessment of this result. We explore the evolution of chemical purity capabilities across metrology institute members of the Consultative Committee for Amount of Substance: Metrology in Chemistry and Biology’s Organic Analysis Working Group (OAWG). The OAWG work program has promoted the development of robust measurement capabilities, using indirect “mass balance” determinations via rigorous assessment of impurities and direct determination using quantitative nuclear magnetic resonance spectroscopy methods. A combination of mass balance and qNMR has been shown to provide a best practice approach. Awareness of the importance of the traceability of organic calibrators continues to grow across stakeholder groups, particularly in key areas such as clinical chemistry where activities related to the Joint Committee for Traceability in Laboratory Medicine have raised the profile of traceable calibrators.
      PubDate: 2019-10-08
       
  • Modelling European quality assurance procedures for analysers monitoring
           emissions under the EU’s Industrial Emissions Directive
    • Abstract: Abstract A model has been created to investigate the uncertainty of a gas analyser operating according to the European Standard EN 14181, which ensures that the measurement uncertainty meets the requirements of legislation (Industrial Emissions Directive). This paper summarises the validation and initial results from the model, looking at the effect of varying the uncertainty of the reference method used to calibrate the analyser. The legislation allows the reference method an uncertainty of up to 20 %, but this will influence the quality of the calibration of the analyser. The results illustrate the problem and highlight that it becomes a significant issue when the reference method’s uncertainty is greater than 15 %, with the analyser failing its calibration almost half of the time due to poor reference performance at 20 % uncertainty. The model can be used to test future changes to legislation and can help operators to ensure that they would be able to meet such future measurement challenges.
      PubDate: 2019-08-19
       
 
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