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Publisher: Springer-Verlag (Total: 2352 journals)

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Showing 1 - 200 of 2352 Journals sorted alphabetically
3D Research     Hybrid Journal   (Followers: 18, SJR: 0.214, h-index: 10)
4OR: A Quarterly J. of Operations Research     Hybrid Journal   (Followers: 9, SJR: 1.073, h-index: 25)
AAPS J.     Hybrid Journal   (Followers: 20, SJR: 1.192, h-index: 74)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6, SJR: 0.718, h-index: 54)
Abdominal Imaging     Hybrid Journal   (Followers: 14, SJR: 0.723, h-index: 60)
Abhandlungen aus dem Mathematischen Seminar der Universitat Hamburg     Hybrid Journal   (Followers: 3, SJR: 0.447, h-index: 12)
Academic Psychiatry     Full-text available via subscription   (Followers: 22, SJR: 0.492, h-index: 32)
Academic Questions     Hybrid Journal   (Followers: 7, SJR: 0.135, h-index: 6)
Accreditation and Quality Assurance: J. for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 26, SJR: 0.378, h-index: 30)
Acoustical Physics     Hybrid Journal   (Followers: 11, SJR: 0.355, h-index: 20)
Acoustics Australia     Hybrid Journal  
Acta Analytica     Hybrid Journal   (Followers: 7, SJR: 0.387, h-index: 6)
Acta Applicandae Mathematicae     Hybrid Journal   (Followers: 1, SJR: 0.624, h-index: 34)
Acta Biotheoretica     Hybrid Journal   (Followers: 5, SJR: 0.419, h-index: 25)
Acta Diabetologica     Hybrid Journal   (Followers: 14, SJR: 1.318, h-index: 46)
Acta Endoscopica     Hybrid Journal   (Followers: 1, SJR: 0.113, h-index: 8)
acta ethologica     Hybrid Journal   (Followers: 4, SJR: 0.465, h-index: 23)
Acta Geochimica     Hybrid Journal   (Followers: 5)
Acta Geodaetica et Geophysica     Hybrid Journal   (Followers: 1, SJR: 0.294, h-index: 13)
Acta Geotechnica     Hybrid Journal   (Followers: 7, SJR: 1.818, h-index: 22)
Acta Informatica     Hybrid Journal   (Followers: 5, SJR: 0.524, h-index: 32)
Acta Mathematica     Hybrid Journal   (Followers: 11, SJR: 8.021, h-index: 47)
Acta Mathematica Hungarica     Hybrid Journal   (Followers: 2, SJR: 0.53, h-index: 29)
Acta Mathematica Sinica, English Series     Hybrid Journal   (Followers: 5, SJR: 0.406, h-index: 30)
Acta Mathematica Vietnamica     Hybrid Journal   (SJR: 0.451, h-index: 5)
Acta Mathematicae Applicatae Sinica, English Series     Hybrid Journal   (SJR: 0.22, h-index: 20)
Acta Mechanica     Hybrid Journal   (Followers: 20, SJR: 0.898, h-index: 52)
Acta Mechanica Sinica     Hybrid Journal   (Followers: 5, SJR: 0.426, h-index: 29)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 5, SJR: 0.525, h-index: 18)
Acta Meteorologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.524, h-index: 14)
Acta Neurochirurgica     Hybrid Journal   (Followers: 6, SJR: 0.833, h-index: 73)
Acta Neurologica Belgica     Hybrid Journal   (SJR: 0.348, h-index: 27)
Acta Neuropathologica     Hybrid Journal   (Followers: 5, SJR: 6.61, h-index: 117)
Acta Oceanologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.295, h-index: 17)
Acta Parasitologica     Hybrid Journal   (Followers: 9, SJR: 0.581, h-index: 28)
Acta Physiologiae Plantarum     Hybrid Journal   (Followers: 2, SJR: 0.551, h-index: 39)
Acta Politica     Hybrid Journal   (Followers: 13, SJR: 0.658, h-index: 20)
Activitas Nervosa Superior     Hybrid Journal  
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 5, SJR: 0.103, h-index: 4)
ADHD Attention Deficit and Hyperactivity Disorders     Hybrid Journal   (Followers: 23, SJR: 0.871, h-index: 15)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 8)
Administration and Policy in Mental Health and Mental Health Services Research     Partially Free   (Followers: 15, SJR: 0.795, h-index: 40)
Adsorption     Hybrid Journal   (Followers: 4, SJR: 0.774, h-index: 52)
Advances in Applied Clifford Algebras     Hybrid Journal   (Followers: 3, SJR: 0.319, h-index: 15)
Advances in Atmospheric Sciences     Hybrid Journal   (Followers: 34, SJR: 0.959, h-index: 44)
Advances in Computational Mathematics     Hybrid Journal   (Followers: 15, SJR: 1.255, h-index: 44)
Advances in Contraception     Hybrid Journal   (Followers: 3)
Advances in Data Analysis and Classification     Hybrid Journal   (Followers: 52, SJR: 1.113, h-index: 14)
Advances in Gerontology     Partially Free   (Followers: 9, SJR: 0.141, h-index: 3)
Advances in Health Sciences Education     Hybrid Journal   (Followers: 22, SJR: 1.397, h-index: 42)
Advances in Manufacturing     Hybrid Journal   (Followers: 3, SJR: 0.2, h-index: 4)
Advances in Polymer Science     Hybrid Journal   (Followers: 41, SJR: 0.637, h-index: 89)
Advances in Therapy     Hybrid Journal   (Followers: 5, SJR: 0.79, h-index: 44)
Aegean Review of the Law of the Sea and Maritime Law     Hybrid Journal   (Followers: 7)
Aequationes Mathematicae     Hybrid Journal   (Followers: 2, SJR: 0.882, h-index: 23)
Aerobiologia     Hybrid Journal   (Followers: 1, SJR: 0.511, h-index: 36)
Aesthetic Plastic Surgery     Hybrid Journal   (Followers: 9, SJR: 0.821, h-index: 49)
African Archaeological Review     Hybrid Journal   (Followers: 15, SJR: 0.612, h-index: 24)
Afrika Matematika     Hybrid Journal   (Followers: 1, SJR: 0.248, h-index: 6)
AGE     Hybrid Journal   (Followers: 7, SJR: 1.358, h-index: 33)
Ageing Intl.     Hybrid Journal   (Followers: 7, SJR: 0.337, h-index: 10)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
Aging Clinical and Experimental Research     Hybrid Journal   (Followers: 3, SJR: 0.529, h-index: 55)
Agricultural Research     Hybrid Journal   (Followers: 3)
Agriculture and Human Values     Hybrid Journal   (Followers: 12, SJR: 1.197, h-index: 49)
Agroforestry Systems     Hybrid Journal   (Followers: 19, SJR: 0.64, h-index: 56)
Agronomy for Sustainable Development     Hybrid Journal   (Followers: 10, SJR: 1.732, h-index: 59)
AI & Society     Hybrid Journal   (Followers: 7, SJR: 0.171, h-index: 19)
AIDS and Behavior     Hybrid Journal   (Followers: 13, SJR: 2.006, h-index: 71)
Air Quality, Atmosphere & Health     Hybrid Journal   (Followers: 4, SJR: 0.706, h-index: 19)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Algebra and Logic     Hybrid Journal   (Followers: 4, SJR: 0.566, h-index: 18)
Algebra Universalis     Hybrid Journal   (Followers: 2, SJR: 0.388, h-index: 22)
Algebras and Representation Theory     Hybrid Journal   (Followers: 1, SJR: 0.868, h-index: 20)
Algorithmica     Hybrid Journal   (Followers: 8, SJR: 0.898, h-index: 56)
Allergo J.     Full-text available via subscription   (Followers: 1, SJR: 0.183, h-index: 20)
Allergo J. Intl.     Hybrid Journal   (Followers: 2)
Alpine Botany     Hybrid Journal   (Followers: 5, SJR: 0.729, h-index: 20)
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 3, SJR: 1.392, h-index: 32)
AMBIO     Hybrid Journal   (Followers: 15, SJR: 1.094, h-index: 87)
American J. of Cardiovascular Drugs     Hybrid Journal   (Followers: 15, SJR: 0.864, h-index: 39)
American J. of Community Psychology     Hybrid Journal   (Followers: 24, SJR: 1.237, h-index: 83)
American J. of Criminal Justice     Hybrid Journal   (Followers: 6, SJR: 0.634, h-index: 13)
American J. of Cultural Sociology     Hybrid Journal   (Followers: 12, SJR: 0.283, h-index: 3)
American J. of Dance Therapy     Hybrid Journal   (Followers: 4, SJR: 0.175, h-index: 13)
American J. of Potato Research     Hybrid Journal   (Followers: 2, SJR: 0.558, h-index: 35)
American J. of Psychoanalysis     Hybrid Journal   (Followers: 22, SJR: 0.293, h-index: 13)
American Sociologist     Hybrid Journal   (Followers: 14, SJR: 0.18, h-index: 13)
Amino Acids     Hybrid Journal   (Followers: 8, SJR: 1.362, h-index: 83)
AMS Review     Partially Free   (Followers: 4)
Analog Integrated Circuits and Signal Processing     Hybrid Journal   (Followers: 7, SJR: 0.21, h-index: 37)
Analysis and Mathematical Physics     Hybrid Journal   (Followers: 3, SJR: 0.665, h-index: 7)
Analysis in Theory and Applications     Hybrid Journal   (Followers: 1)
Analysis of Verbal Behavior     Hybrid Journal   (Followers: 5)
Analytical and Bioanalytical Chemistry     Hybrid Journal   (Followers: 30, SJR: 1.096, h-index: 123)
Anatomical Science Intl.     Hybrid Journal   (Followers: 2, SJR: 0.301, h-index: 26)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3, SJR: 2.212, h-index: 69)
Animal Cognition     Hybrid Journal   (Followers: 16, SJR: 1.122, h-index: 55)
Annales françaises de médecine d'urgence     Hybrid Journal   (Followers: 1, SJR: 0.156, h-index: 4)
Annales Henri Poincaré     Hybrid Journal   (Followers: 3, SJR: 1.377, h-index: 32)
Annales mathématiques du Québec     Hybrid Journal   (Followers: 4)
Annali dell'Universita di Ferrara     Hybrid Journal   (SJR: 0.504, h-index: 14)
Annali di Matematica Pura ed Applicata     Hybrid Journal   (Followers: 1, SJR: 1.167, h-index: 26)
Annals of Behavioral Medicine     Hybrid Journal   (Followers: 11, SJR: 2.112, h-index: 98)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18, SJR: 1.182, h-index: 94)
Annals of Combinatorics     Hybrid Journal   (Followers: 3, SJR: 0.849, h-index: 15)
Annals of Data Science     Hybrid Journal   (Followers: 9)
Annals of Dyslexia     Hybrid Journal   (Followers: 9, SJR: 0.857, h-index: 40)
Annals of Finance     Hybrid Journal   (Followers: 28, SJR: 0.686, h-index: 14)
Annals of Forest Science     Hybrid Journal   (Followers: 6, SJR: 0.929, h-index: 57)
Annals of Global Analysis and Geometry     Hybrid Journal   (Followers: 1, SJR: 1.136, h-index: 23)
Annals of Hematology     Hybrid Journal   (Followers: 14, SJR: 1.117, h-index: 62)
Annals of Mathematics and Artificial Intelligence     Hybrid Journal   (Followers: 6, SJR: 0.593, h-index: 42)
Annals of Microbiology     Hybrid Journal   (Followers: 10, SJR: 0.402, h-index: 26)
Annals of Nuclear Medicine     Hybrid Journal   (Followers: 5, SJR: 0.68, h-index: 45)
Annals of Operations Research     Hybrid Journal   (Followers: 8, SJR: 1.186, h-index: 78)
Annals of Ophthalmology     Hybrid Journal   (Followers: 11)
Annals of Regional Science     Hybrid Journal   (Followers: 7, SJR: 0.405, h-index: 42)
Annals of Software Engineering     Hybrid Journal   (Followers: 12)
Annals of Solid and Structural Mechanics     Hybrid Journal   (Followers: 10, SJR: 0.553, h-index: 8)
Annals of Surgical Oncology     Hybrid Journal   (Followers: 15, SJR: 1.902, h-index: 127)
Annals of Telecommunications     Hybrid Journal   (Followers: 7, SJR: 0.315, h-index: 25)
Annals of the Institute of Statistical Mathematics     Hybrid Journal   (Followers: 1, SJR: 0.931, h-index: 31)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 5, SJR: 0.992, h-index: 87)
Apidologie     Hybrid Journal   (Followers: 4, SJR: 1.14, h-index: 57)
APOPTOSIS     Hybrid Journal   (Followers: 8, SJR: 1.554, h-index: 87)
Applicable Algebra in Engineering, Communication and Computing     Hybrid Journal   (Followers: 2, SJR: 0.354, h-index: 27)
Applications of Mathematics     Hybrid Journal   (Followers: 1, SJR: 0.274, h-index: 20)
Applied Biochemistry and Biotechnology     Hybrid Journal   (Followers: 44, SJR: 0.575, h-index: 80)
Applied Biochemistry and Microbiology     Hybrid Journal   (Followers: 17, SJR: 0.267, h-index: 26)
Applied Cancer Research     Open Access  
Applied Categorical Structures     Hybrid Journal   (Followers: 2, SJR: 0.361, h-index: 21)
Applied Composite Materials     Hybrid Journal   (Followers: 48, SJR: 0.705, h-index: 35)
Applied Entomology and Zoology     Partially Free   (Followers: 3, SJR: 0.554, h-index: 34)
Applied Geomatics     Hybrid Journal   (Followers: 3, SJR: 0.323, h-index: 9)
Applied Geophysics     Hybrid Journal   (Followers: 8, SJR: 0.541, h-index: 13)
Applied Intelligence     Hybrid Journal   (Followers: 11, SJR: 0.777, h-index: 43)
Applied Magnetic Resonance     Hybrid Journal   (Followers: 4, SJR: 0.358, h-index: 34)
Applied Mathematics & Optimization     Hybrid Journal   (Followers: 4, SJR: 0.955, h-index: 33)
Applied Mathematics - A J. of Chinese Universities     Hybrid Journal   (SJR: 0.275, h-index: 8)
Applied Mathematics and Mechanics     Hybrid Journal   (Followers: 5, SJR: 0.37, h-index: 26)
Applied Microbiology and Biotechnology     Hybrid Journal   (Followers: 62, SJR: 1.262, h-index: 161)
Applied Physics A     Hybrid Journal   (Followers: 7, SJR: 0.535, h-index: 121)
Applied Physics B: Lasers and Optics     Hybrid Journal   (Followers: 23, SJR: 0.983, h-index: 104)
Applied Psychophysiology and Biofeedback     Hybrid Journal   (Followers: 8, SJR: 0.677, h-index: 47)
Applied Research in Quality of Life     Hybrid Journal   (Followers: 11, SJR: 0.288, h-index: 15)
Applied Solar Energy     Hybrid Journal   (Followers: 16, SJR: 0.251, h-index: 6)
Applied Spatial Analysis and Policy     Hybrid Journal   (Followers: 4, SJR: 0.351, h-index: 9)
Aquaculture Intl.     Hybrid Journal   (Followers: 22, SJR: 0.613, h-index: 40)
Aquarium Sciences and Conservation     Hybrid Journal   (Followers: 1)
Aquatic Ecology     Hybrid Journal   (Followers: 30, SJR: 0.646, h-index: 44)
Aquatic Geochemistry     Hybrid Journal   (Followers: 4, SJR: 0.764, h-index: 39)
Aquatic Sciences     Hybrid Journal   (Followers: 13, SJR: 1.172, h-index: 53)
Arabian J. for Science and Engineering     Hybrid Journal   (Followers: 5, SJR: 0.345, h-index: 20)
Arabian J. of Geosciences     Hybrid Journal   (Followers: 1, SJR: 0.417, h-index: 16)
Archaeological and Anthropological Sciences     Hybrid Journal   (Followers: 22, SJR: 1.056, h-index: 15)
Archaeologies     Hybrid Journal   (Followers: 12, SJR: 0.397, h-index: 13)
Archiv der Mathematik     Hybrid Journal   (Followers: 1, SJR: 0.597, h-index: 29)
Archival Science     Hybrid Journal   (Followers: 54, SJR: 0.804, h-index: 22)
Archive for History of Exact Sciences     Hybrid Journal   (Followers: 7, SJR: 0.28, h-index: 15)
Archive for Mathematical Logic     Hybrid Journal   (Followers: 1, SJR: 0.946, h-index: 23)
Archive for Rational Mechanics and Analysis     Hybrid Journal   (SJR: 4.091, h-index: 66)
Archive of Applied Mechanics     Hybrid Journal   (Followers: 5, SJR: 0.865, h-index: 40)
Archives and Museum Informatics     Hybrid Journal   (Followers: 129)
Archives of Computational Methods in Engineering     Hybrid Journal   (Followers: 4, SJR: 2.841, h-index: 40)
Archives of Dermatological Research     Hybrid Journal   (Followers: 6, SJR: 0.9, h-index: 65)
Archives of Environmental Contamination and Toxicology     Hybrid Journal   (Followers: 11, SJR: 0.846, h-index: 84)
Archives of Gynecology and Obstetrics     Hybrid Journal   (Followers: 17, SJR: 0.695, h-index: 47)
Archives of Microbiology     Hybrid Journal   (Followers: 8, SJR: 0.702, h-index: 85)
Archives of Orthopaedic and Trauma Surgery     Hybrid Journal   (Followers: 8, SJR: 1.039, h-index: 56)
Archives of Osteoporosis     Hybrid Journal   (Followers: 2, SJR: 1.092, h-index: 13)
Archives of Sexual Behavior     Hybrid Journal   (Followers: 9, SJR: 1.198, h-index: 74)
Archives of Toxicology     Hybrid Journal   (Followers: 16, SJR: 1.595, h-index: 76)
Archives of Virology     Hybrid Journal   (Followers: 5, SJR: 1.086, h-index: 90)
Archives of Women's Mental Health     Hybrid Journal   (Followers: 14, SJR: 1.264, h-index: 50)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2, SJR: 1.2, h-index: 42)
ArgoSpine News & J.     Hybrid Journal   (SJR: 0.102, h-index: 3)
Argumentation     Hybrid Journal   (Followers: 5, SJR: 0.295, h-index: 18)
Arid Ecosystems     Hybrid Journal   (Followers: 3)
Arkiv för Matematik     Hybrid Journal   (Followers: 1, SJR: 0.948, h-index: 22)
Arnold Mathematical J.     Hybrid Journal   (Followers: 1)
Arthropod-Plant Interactions     Hybrid Journal   (Followers: 2, SJR: 0.797, h-index: 17)
Arthroskopie     Hybrid Journal   (Followers: 1, SJR: 0.145, h-index: 8)
Artificial Intelligence and Law     Hybrid Journal   (Followers: 10, SJR: 0.288, h-index: 25)
Artificial Intelligence Review     Hybrid Journal   (Followers: 14, SJR: 0.948, h-index: 48)
Artificial Life and Robotics     Hybrid Journal   (Followers: 8, SJR: 0.231, h-index: 14)
Asia Europe J.     Hybrid Journal   (Followers: 5, SJR: 0.247, h-index: 9)
Asia Pacific Education Review     Hybrid Journal   (Followers: 11, SJR: 0.371, h-index: 17)
Asia Pacific J. of Management     Hybrid Journal   (Followers: 15, SJR: 1.676, h-index: 50)
Asia-Pacific Education Researcher     Hybrid Journal   (Followers: 11, SJR: 0.353, h-index: 13)
Asia-Pacific Financial Markets     Hybrid Journal   (Followers: 2, SJR: 0.19, h-index: 15)
Asia-Pacific J. of Atmospheric Sciences     Hybrid Journal   (Followers: 20, SJR: 1.006, h-index: 14)
Asian Business & Management     Hybrid Journal   (Followers: 8, SJR: 0.41, h-index: 10)
Asian J. of Business Ethics     Hybrid Journal   (Followers: 7)
Asian J. of Criminology     Hybrid Journal   (Followers: 5, SJR: 0.263, h-index: 8)
AStA Advances in Statistical Analysis     Hybrid Journal   (Followers: 2, SJR: 0.681, h-index: 15)
AStA Wirtschafts- und Sozialstatistisches Archiv     Hybrid Journal   (Followers: 5, SJR: 0.195, h-index: 5)
ästhetische dermatologie & kosmetologie     Full-text available via subscription  

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Journal Cover Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement
  [SJR: 0.378]   [H-I: 30]   [26 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 0949-1775 - ISSN (Online) 1432-0517
   Published by Springer-Verlag Homepage  [2352 journals]
  • Full method validation in clinical chemistry
    • Authors: Elvar Theodorsson; Bertil Magnusson
      Pages: 235 - 246
      Abstract: Abstract Clinical chemistry is subject to the same principles and standards used in all branches of metrology in chemistry for validation of measurement methods. The use of measuring systems in clinical chemistry is, however, of exceptionally high volume, diverse and involves many laboratories and systems. Samples for measuring the same measurand from a certain patient are likely to encounter several measuring systems over time in the process of diagnosis and treatment of his/her diseases. Several challenges regarding method validation across several laboratories are therefore evident, but rarely addressed in current standards and accreditation practices. The purpose of this is paper to address some of these challenges, making a case that appropriate conventional method validation performed by the manufacturers fulfils only a part of the investigation needed to show that they are fit for purpose in different healthcare circumstances. Method validation across several laboratories using verified commercially available measuring systems can only be performed by the laboratories—users themselves in their own circumstances, and need to be emphasised more by the laboratories themselves and accreditation authorities alike.
      PubDate: 2017-10-01
      DOI: 10.1007/s00769-017-1275-7
      Issue No: Vol. 22, No. 5 (2017)
       
  • Method validation in analytical sciences: discussions on current practice
           and future challenges
    • Authors: Vicki Barwick; Stephen L. R. Ellison; Elin Gjengedal; Bertil Magnusson; Olivier Molinier; Marina Patriarca; Lorens Sibbesen; Nicole Vanlaethem; Isabelle Vercruysse
      Pages: 253 - 263
      Abstract: Abstract Eurachem held a workshop on method validation in analytical sciences in Gent, Belgium, on 9–10 May 2016. A summary of the working group discussions is provided here. The discussions covered a range of issues concerned with current practice and future challenges in method validation, i.e. setting requirements for a method to be validated; planning validation studies; validation of qualitative and semi-quantitative methods; validation of multi-parameter methods; determination of trueness/bias; assessment of working range; validation in microbiology; and method validation under flexible scope of accreditation. Delegates (129) from 24 different countries and from different backgrounds, e.g. from both public and private laboratories, laboratory associations, accreditation bodies and universities, attended the working groups, thus providing opportunities to collect a variety of views and experiences as well as to identify potential gaps in current guidance and regulations. While the practicalities of assessing method performance characteristics are generally well understood, the issue of setting requirements for those characteristics beforehand is less straightforward. Although a number of documents addressing the principles of method validation are available, guidance on dealing with more complex and ‘non-ideal’ situations, as well as examples of good practice, would be welcomed and greater harmonisation of approaches was deemed necessary. There remains a need for guidance on both the concepts that apply to ‘qualitative’ or ‘nominal’ test methods and on the practical implementation of validation studies in such cases.
      PubDate: 2017-10-01
      DOI: 10.1007/s00769-017-1286-4
      Issue No: Vol. 22, No. 5 (2017)
       
  • Congress, conferences, workshops and courses
    • Pages: 233 - 233
      PubDate: 2017-08-01
      DOI: 10.1007/s00769-017-1278-4
      Issue No: Vol. 22, No. 4 (2017)
       
  • Correction to: Uncertainty estimation of the determination of chemical sum
           parameters in water
    • Authors: Tony Venelinov
      Abstract: Abstract Unfortunately, Eq. 3 was incorrectly presented in the original publication.
      PubDate: 2017-10-10
      DOI: 10.1007/s00769-017-1290-8
       
  • Classification of objects into quality categories in the presence of
           hierarchical decision-making agents
    • Authors: Fiorenzo Franceschini; Domenico Maisano
      Abstract: Abstract In many practical contexts, it is often required to classify some objects of interest into predetermined unordered quality categories. This operation—referred to as quality classification problem—has received considerable attention in many fields of research, such as Analytical Chemistry, Materials Science, Medicine, Manufacturing, Quality Engineering/Management, Decision Analysis. Assuming that multiple agents perform subjective assignments of categories to the objects of interest, a further problem is that of fusing these assignments into global classifications. To this purpose, the mode and the weighted mode are very practical measures, as long as agents are equi-important or their (different) importance is expressed in the form of a set of weights. Unfortunately, these measures are not appropriate for quality classification problems where the agents’ importance is expressed in the form of a rank ordering (hierarchy). The aim of this article is to present a new method, which addresses the latter quality classification problem in a relatively simple and practical way. The peculiarity of this method is that the different importance of agents determines a different priority in considering their assignments and not a different weight of these assignments. A detailed description of the new method is supported by a realistic example in the Analytical Chemistry field.
      PubDate: 2017-10-07
      DOI: 10.1007/s00769-017-1291-7
       
  • The new International Standard ISO 17034: general requirements for the
           competence of reference material producers
    • Authors: Stefanie Trapmann; Angelique Botha; Thomas P. J. Linsinger; Sean Mac Curtain; Hendrik Emons
      Abstract: Abstract The International Organization for Standardization (ISO) has published ISO 17034:2016 on the general requirements for the competence of reference material producers (RMPs). Previously, these requirements were addressed in ISO Guide 34:2009, originally developed by the ISO Committee on Reference Materials (ISO/REMCO). The need for an International Standard was triggered as several accreditation bodies could not accredit to a guide, at all, while in other countries ISO Guide 34 could only serve as accreditation standard in combination with ISO/IEC 17025. For the transformation into a conformity assessment standard of the ISO/IEC 17000 series, the ISO Committee on Conformity assessment (ISO/CASCO) and ISO/REMCO joined forces. A Joint Working Group, formed by experts and stakeholders from both committees, finalised the transformation within 2 years. During the transformation, the structure of ISO 17034 has been aligned with other ISO/IEC 17000 series standards and the content of ISO 17034 has been harmonised with the recent editions of other relevant ISO Guides. Requirements for the production of reference materials (RMs) were elaborated on more clearly in the new standard, specifying the requirements for (non-certified) reference materials and the additional requirements for certified reference materials. The new International Standard ISO 17034:2016 supersedes ISO Guide 34:2009.
      PubDate: 2017-09-26
      DOI: 10.1007/s00769-017-1285-5
       
  • Determination and quality evaluation of six components in Zhou’s
           Prescription through quantitative analysis of multi-components by single
           marker
    • Authors: Cuicui Gu; Fang Wu; Yanmei Cao; Lian Yin; Xu Zhang; Lihong Ye; Zhongying Zhou
      Abstract: Abstract Zhou’s Prescription is a compound prescription with traditional Chinese medicine, which is composed of 13 kinds of herbs and has been used to treat lung cancer in clinical practice for many years in China. Quantitative analysis of multi-components with single marker (QAMS) was used for the first time to analyze Zhou’s Prescription for the mass contents of six active ingredients, and chemometric methods were applied to evaluate its quality. Quercetin was selected as the internal standard serving as basis for relative correction factors (RCFs) determined using different HPLC instruments and columns. The contents of the active ingredients hydroxysafflor yellow A, rutin, hyperoside, isoquercitrin and quercitrin were calculated applying the RCFs. The stability and accuracy of QAMS were tested and verified by an external standard method (ESM). The accuracy was between 94.5 % and 100.4 % demonstrating the consistency of QAMS and ESM. Hierarchical cluster analysis (HCA) and principal component analysis (PCA) were applied to classify 21 batches of Zhou’s Prescription which were composed with supplies of the 13 herbs from different harvests at different producing regions. Among the 21 batches, a significant difference between the contents of the active ingredients was found which can be distinguished by chemometric methods. QAMS proved to be a promising and accurate method to quantify the active ingredients in Zhou’s Prescription also when resources of reference substances are limited. Moreover, the quality of Zhou’s Prescription is determined by the content of active ingredients scaled by HPLC. The method is based on QAMS combined with HCA and PCA to comprehensively evaluate the quality of Zhou’s Prescription composed of herbs of different sources.
      PubDate: 2017-09-18
      DOI: 10.1007/s00769-017-1287-3
       
  • Congress, conferences, workshops and courses
    • PubDate: 2017-09-06
      DOI: 10.1007/s00769-017-1289-1
       
  • Investigation of homogeneity and stability of items for proficiency
           testing of solid recovered fuels (SRF) analysis
    • Authors: Barbara Jagustyn; Agnieszka Plis; Mariusz Mastalerz; Joanna Hrabak; Marek Ściążko
      Abstract: Abstract Solid recovered fuel (SRF) is made of waste and used as a substitute for fossil fuel. Physical and chemical analyses are needed to evaluate the usefulness of the waste in power and heat generation. This paper reports the assessment of homogeneity and stability of laboratory and analytical samples, with different particle size, obtained from three materials of different composition. The components of first material included soft plastics, plastics foam, composite packaging with the content of aluminum foil, cigarette filters, paper, cardboard, textiles, wood, and cotton. The second material mainly contained soft plastics and the needles from artificial Christmas trees, a lower amount of artificial leather, and aluminum foil. The third material was mainly composed of soft plastics and paper. The parameter used in the homogeneity and stability assessment was ash content on a dry basis. The homogeneity and stability assessment was carried out according to ISO 13528:2015; on the basis of a standard deviation for proficiency assessment calculated using the repeatability and reproducibility standard deviations from a previous collaborative study of precision of a measurement method. The homogeneity assessment was carried out using laboratory and analytical samples of SRF. Based on measurements of ash content, laboratory samples as the test items OB1 with a particle size below 4 mm were not sufficiently homogeneous, regardless of the SRF type, among our samples those with the largest particles. The analytical samples as the test items OB2 with a particle size below 1 mm and OB3 with a particle size below 0.5 mm were sufficiently homogeneous. For these samples, the stability assessment was carried out and studied samples were stable. The homogeneity and stability of SRF material were associated not so much with the grinding but the composition of the material.
      PubDate: 2017-08-22
      DOI: 10.1007/s00769-017-1283-7
       
  • Analysis of findings throughout the cycles of accreditation of veterinary
           diagnostic testing laboratories for diseases transmitted by products of
           animal origin
    • Authors: Patricia Weigert de Camargo; Elmiro Rosendo do Nascimento; Maria Helena Cosendey de Aquino
      Abstract: Abstract This work describes the frequency of findings registered in the assessment reports of 23 Brazilian animal health laboratories from 2008 to 2016. The study was conducted in consideration of the ISO/IEC 17025 requirements and normative documents issued by the Brazilian Accreditation Body [General Coordination for Accreditation (Cgcre)]. The general performance of these laboratories throughout the evaluation cycles was investigated. The types and number of findings reported in the assessments of these laboratories were analyzed according to the management and technical requirements of ISO/IEC 17025 and Cgcre’s normative documents. The laboratories’ performance was compared in consideration of the number of findings reported in the first and last assessments of each laboratory investigated.
      PubDate: 2017-08-18
      DOI: 10.1007/s00769-017-1284-6
       
  • Are the present measurement standards still valid after SI
           redefinition'
    • Authors: Franco Pavese
      Abstract: Abstract The SI revision potentially places some basic concerns to all users, one being the validity of their present standards under the new definition. The paper compares what is spelled out in the new SI Brochure draft to what should be specified for practical implementation. The result of the analysis is uncertain for some level of implementation and some standards, with, on the other hand, some positive aspects also illustrated in the paper, not always found explicit in the formal texts.
      PubDate: 2017-08-16
      DOI: 10.1007/s00769-017-1282-8
       
  • National interlaboratory comparisons in the field of breath alcohol
           analyzers calibration, performed in Poland, 2014–2016
    • Authors: Piotr Janko; Robert Kordulasiński; Jolanta Wasilewska; Elżbieta Lenard
      Abstract: Abstract Proficiency testing (PT) and interlaboratory comparisons (ILC) are basic tools of external quality assurance in testing and calibration laboratories. Seeking to meet the needs and expectations of all stakeholders, the Central Office of Measures (GUM) provides ILC in the field of calibration of breath alcohol analyzers. This article describes a series of twelve bilateral ILCs conducted sequentially from December 2014 until July 2016. Eleven laboratories, accredited or in the process of preparation for accreditation, participated in these comparisons. Comparisons encompassed calibration of the same Intox II EC/IR analyzer at four test points: 0.10 mg/L, 0.25 mg/L, 0.41 mg/L, 1.52 mg/L. The results of participant performance evaluation, the results of the density measurements of participants’ liquid ethanol standards and the results of correlation analysis at four calibration points are presented. Nine out of eleven participants obtained all satisfactory results. One of the remaining laboratories confirmed the effectiveness of implemented remedial actions by successful participation in repeated ILC. Laboratories with satisfactory performance confirmed the declared uncertainty.
      PubDate: 2017-08-09
      DOI: 10.1007/s00769-017-1280-x
       
  • Method validation for determination of amino acids in feed by UPLC
    • Authors: Katarzyna Szkudzińska; Ilona Smutniak; Jolanta Rubaj; Waldemar Korol; Grażyna Bielecka
      Abstract: Abstract The paper presents results of validation of an analytical procedure based on ultra-performance liquid chromatography technique (UPLC) for determination of 17 amino acids in different feeds. The following performance characteristics were determined for the investigated feeds: relative standard deviations of repeatability and intermediate precisions ranged from 0.4 % to 4.6 %, and from 0.8 % to 7.9 %, respectively; recovery rates ranged from 87 % to 104 %, and limit of detection was from 0.06 g kg−1 (methionine) to 0.72 g kg−1 (glutamic acid). Two approaches were used to estimate measurement uncertainty giving values in a range of 5.1 % to 5.5 %. These performance characteristics are in agreement with the values reported in Commission Regulation (EU) No 152/2009 for the ion exchange chromatography with spectrophotometric detection.
      PubDate: 2017-08-01
      DOI: 10.1007/s00769-017-1281-9
       
  • Development of primary standard gas mixtures containing 10 µmol/mol
           oxygen in nitrogen with verification by a two-oven GC-TCD system for
           effective separation of oxygen from argon in presence of plenty of
           nitrogen
    • Authors: Takuya Shimosaka
      Abstract: Abstract Primary standard gas mixtures (PSMs) containing 10 µmol/mol oxygen in nitrogen were prepared in aluminum alloy cylinders from pure nitrogen and oxygen gases according to ISO 6142-1. We developed a system consisting of a gas chromatograph with a thermal conductivity detector (GC-TCD) and two ovens to verify precisely the amount-of-substance fraction of oxygen in the PSMs at a level of 10 µmol/mol. As pure nitrogen gas usually contains argon as an impurity, it is necessary to separate the oxygen peak from the argon peak in order to verify the amount-of-substance fraction of oxygen in the PSMs. Although the use of packed columns is essential in order to achieve high precision using a GC-TCD system, it is notoriously difficult to separate oxygen and argon by this method. To overcome this problem, we used two gas chromatograph ovens: The first oven separates oxygen and argon from the nitrogen, whereas the second oven—held at −15 °C or below—separates oxygen and argon. The two-oven GC-TCD system was able to achieve good resolution between the oxygen and argon peaks. The relative uncertainty in the determination of the oxygen fraction obtained using this system was 0.35 %. In order to avoid adsorption of oxygen onto the inner surface of the aluminum cylinder, we pretreated each cylinder by filling it with a standard gas mixture of oxygen in nitrogen at an oxygen partial pressure similar to that of the PSMs. The cylinders were then evacuated and used for the preparation of the target PSMs. From long-term monitoring using the GC-TCD system, we found the PSMs containing 10 µmol/mol oxygen in nitrogen to be stable for at least 30 months. The expanded combined uncertainties for the PSMs (k = 2) were found to be 0.026 µmol/mol to 0.036 µmol/mol, according to ISO 6142-1.
      PubDate: 2017-07-21
      DOI: 10.1007/s00769-017-1279-3
       
  • G. Férard, R. Dybkaer and X. Fuentes-Arderiu: Compendium of terminology
           and nomenclature of properties in clinical laboratory sciences,
           recommendations 2016 (Silver Book, 2nd ed.)
    • Authors: David B. Hibbert
      PubDate: 2017-07-12
      DOI: 10.1007/s00769-017-1277-5
       
  • Uncertainty evaluation for the determination of the dissolved fraction of
           sulpiride content in tablets
    • Authors: Biying Du
      Abstract: Abstract The aim of this work was to establish a mathematical model to identify the main source of measurement uncertainty, quantify each uncertainty component, and calculate the combined and expanded uncertainties for determination of the fraction of sulpiride dissolved from tablets by UV spectrophotometry. The uncertainties on the absorbance (sample and standard), volumetric flasks and volumetric pipettes have important influence on the overall uncertainty. The average sulpiride fraction released from six tablets was 75.5 %, with an expanded uncertainty of 3.7 % (k = 2). Uncertainty is a relevant tool in assessment of compliance or non-compliance of in-process and final pharmaceutical products. Evaluation of the uncertainty of the dissolution measurement contributes to scientific explanation and interpretation of testing data, and ensures the results to be more accurate, impartial and convincing when testing a sample against specification or legislation.
      PubDate: 2017-06-29
      DOI: 10.1007/s00769-017-1273-9
       
  • A statistical procedure for the assessment of bias in analytical methods
           using conditional probabilities
    • Authors: Robert B. Frenkel; Ian Farrance
      Abstract: Abstract A new approach is described for the simultaneous treatment of bias and imprecision in clinical chemistry. The approach makes use of the general law of conditional probabilities. The result is a density distribution of the measurand that incorporates both imprecision and bias and avoids the contentious linear combination of these quantities as a ‘total error’. This leads naturally to a figure-of-merit in proficiency testing or method comparison that has intuitive visual appeal. We also discuss an established figure-of-merit in proficiency testing, namely the E n number.
      PubDate: 2017-06-29
      DOI: 10.1007/s00769-017-1274-8
       
  • Development of milk powder reference material and its use for evaluation
           of laboratory performance on analysis of mandatory nutrients for nutrition
           labelling in Thailand
    • Authors: Kunchit Judprasong; Prapasri Puwastien; Jutharat Supanuwat; Sitima Jittinandana; Naruemol Pinprapai
      Abstract: Abstract This study investigated the laboratory performance on the analyses of mandatory nutrients for nutrition labelling in Thailand and aimed to upgrade the proficiency test (PT) material into a reference material (RM). This milk powder with sufficient homogeneity and multiple nutrient compositions provided an acceptable PT material. Twenty ISO 17025 accredited laboratories participated in this study, and analytical performance was investigated using ISO 17043 and ISO 13528 standards. Satisfactory performance ( z ≤ 2, for both within- and between-laboratory variations) was found among participating laboratories on the analyses of total fat, saturated fat, cholesterol, protein, sugar, sodium, vitamin B1, vitamin B2, calcium, iron, moisture, and ash. The values of these nutrients (mean and standard deviation) were applied to upgrade the PT material to be used as a reference material. For a trial, moisture, vitamin B1, and vitamin B2 were selected as three representative nutrients to develop reference values as mean and uncertainty following ISO Guides 34 and 35 for RM production. The mean of moisture, vitamin B1, and vitamin B2 values of 2.34 g/(100 g), 0.64 mg/(100 g), and 0.78 mg/(100 g) were obtained with the relative expanded uncertainty of 12.2 %, 12.7 %, and 9.7 %, respectively. The developed RM can be used as quality control sample or as PT material with reference nutrient values among the laboratories in Thailand.
      PubDate: 2017-05-26
      DOI: 10.1007/s00769-017-1269-5
       
  • Evolution of quality on pharmaceutical design: regulatory requirement?
    • Authors: AnaCerúlia Moraes doCarmo; Marcilio S. S. Cunha-Filho; Guilherme Martins Gelfuso; Tais Gratieri
      Abstract: Abstract Quality by design (QbD) concept was first outlined by quality pioneer Joseph M. Juran, who believed quality could be designed into a product, preventing, therefore, most quality problems, normally related to the way quality was planned. This concept, as others related to quality conception and management, has already been applied by other industries, as automotive, and later introduced to pharmaceutical industry through US Food and Drug Administration and The International Council on Harmonization of Technical Requirements for Medicinal Products for Human Use guidelines. Brazil mostly applies statistical quality control and still does not have specific regulations regarding QbD, neither other countries in Latin America. Thus, the current stage of pharmaceutical quality regulation in Latin America must be understood to implement better strategies that can positively affect the development of drug products to reach advanced levels of quality. This article reviews aspects related to quality of pharmaceutics and assesses data to analyze whether Brazilian pharmaceutical industry can adapt to this scenario as a pilot for other South American countries.
      PubDate: 2017-05-26
      DOI: 10.1007/s00769-017-1270-z
       
  • Establishment of an analytical method for accurate purity evaluations of
           acylcarnitines by using quantitative 1 H NMR spectroscopy
    • Authors: Naoki Saito; Takeshi Saito; Taichi Yamazaki; Yoshinori Fujimine; Toshihide Ihara
      Abstract: Abstract Recently, it has become possible to examine metabolism abnormalities by detecting increases in specific acylcarnitines in blood tests of newborn babies using tandem mass spectrometer. However, acylcarnitine standard solutions with metrological traceability to the International System of Units (SI) for accurate calibration of tandem mass spectrometer are not yet available worldwide. In this study, we examined a quantitative 1H NMR procedure for obtaining accurate and SI-traceable purity evaluations of acylcarnitines having different numbers of carbon atoms as each raw material for their standard solutions. In particular, the solvent composition and measurement temperature were optimized to reduce the influence of water signal overlapping on analyte signals. It was found that, when the signal of that 1H which directly bound to the asymmetric carbon of the acylcarnitine is the target signal, it was possible to reduce overlapping of the water signal on the target signal by using deuterium oxide as a solvent. On the other hand, in the case of an acylcarnitine that was poorly soluble in deuterium oxide, it was possible to reduce overlapping of the water signal on the target signal by adding an appropriate amount of deuterium oxide to methanol-d 4 in which the acylcarnitine had high solubility. At this time, the optimum mixing volume ratio of methanol-d 4/deuterium would be 80:20. The overlapping of the water signal could be also reduced when the measurement temperature was 15 °C to 40 °C. When the measurement temperature was an around room temperature (in this study, 25 °C), fine shimming could be performed easily. Therefore, the optimum temperature would be 25 °C, because fine shimming was essential to quantify any signal area accurately. Finally, this study confirmed that accurate values with SI traceability could be obtained at about 1 % or less expanded uncertainty for five kinds of acylcarnitines.
      PubDate: 2017-04-29
      DOI: 10.1007/s00769-017-1263-y
       
 
 
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