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Publisher: Springer-Verlag (Total: 2352 journals)

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Showing 1 - 200 of 2352 Journals sorted alphabetically
3D Research     Hybrid Journal   (Followers: 17, SJR: 0.214, h-index: 10)
4OR: A Quarterly J. of Operations Research     Hybrid Journal   (Followers: 10, SJR: 1.073, h-index: 25)
AAPS J.     Hybrid Journal   (Followers: 20, SJR: 1.192, h-index: 74)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6, SJR: 0.718, h-index: 54)
Abdominal Imaging     Hybrid Journal   (Followers: 14, SJR: 0.723, h-index: 60)
Abhandlungen aus dem Mathematischen Seminar der Universitat Hamburg     Hybrid Journal   (Followers: 3, SJR: 0.447, h-index: 12)
Academic Psychiatry     Full-text available via subscription   (Followers: 22, SJR: 0.492, h-index: 32)
Academic Questions     Hybrid Journal   (Followers: 8, SJR: 0.135, h-index: 6)
Accreditation and Quality Assurance: J. for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 26, SJR: 0.378, h-index: 30)
Acoustical Physics     Hybrid Journal   (Followers: 11, SJR: 0.355, h-index: 20)
Acoustics Australia     Hybrid Journal  
Acta Analytica     Hybrid Journal   (Followers: 7, SJR: 0.387, h-index: 6)
Acta Applicandae Mathematicae     Hybrid Journal   (Followers: 1, SJR: 0.624, h-index: 34)
Acta Biotheoretica     Hybrid Journal   (Followers: 5, SJR: 0.419, h-index: 25)
Acta Diabetologica     Hybrid Journal   (Followers: 14, SJR: 1.318, h-index: 46)
Acta Endoscopica     Hybrid Journal   (Followers: 1, SJR: 0.113, h-index: 8)
acta ethologica     Hybrid Journal   (Followers: 4, SJR: 0.465, h-index: 23)
Acta Geochimica     Hybrid Journal   (Followers: 5)
Acta Geodaetica et Geophysica     Hybrid Journal   (Followers: 1, SJR: 0.294, h-index: 13)
Acta Geotechnica     Hybrid Journal   (Followers: 7, SJR: 1.818, h-index: 22)
Acta Informatica     Hybrid Journal   (Followers: 5, SJR: 0.524, h-index: 32)
Acta Mathematica     Hybrid Journal   (Followers: 11, SJR: 8.021, h-index: 47)
Acta Mathematica Hungarica     Hybrid Journal   (Followers: 2, SJR: 0.53, h-index: 29)
Acta Mathematica Sinica, English Series     Hybrid Journal   (Followers: 6, SJR: 0.406, h-index: 30)
Acta Mathematica Vietnamica     Hybrid Journal   (SJR: 0.451, h-index: 5)
Acta Mathematicae Applicatae Sinica, English Series     Hybrid Journal   (SJR: 0.22, h-index: 20)
Acta Mechanica     Hybrid Journal   (Followers: 20, SJR: 0.898, h-index: 52)
Acta Mechanica Sinica     Hybrid Journal   (Followers: 5, SJR: 0.426, h-index: 29)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 5, SJR: 0.525, h-index: 18)
Acta Meteorologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.524, h-index: 14)
Acta Neurochirurgica     Hybrid Journal   (Followers: 6, SJR: 0.833, h-index: 73)
Acta Neurologica Belgica     Hybrid Journal   (SJR: 0.348, h-index: 27)
Acta Neuropathologica     Hybrid Journal   (Followers: 5, SJR: 6.61, h-index: 117)
Acta Oceanologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.295, h-index: 17)
Acta Parasitologica     Hybrid Journal   (Followers: 9, SJR: 0.581, h-index: 28)
Acta Physiologiae Plantarum     Hybrid Journal   (Followers: 2, SJR: 0.551, h-index: 39)
Acta Politica     Hybrid Journal   (Followers: 13, SJR: 0.658, h-index: 20)
Activitas Nervosa Superior     Hybrid Journal  
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 5, SJR: 0.103, h-index: 4)
ADHD Attention Deficit and Hyperactivity Disorders     Hybrid Journal   (Followers: 22, SJR: 0.871, h-index: 15)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 8)
Administration and Policy in Mental Health and Mental Health Services Research     Partially Free   (Followers: 15, SJR: 0.795, h-index: 40)
Adsorption     Hybrid Journal   (Followers: 4, SJR: 0.774, h-index: 52)
Advances in Applied Clifford Algebras     Hybrid Journal   (Followers: 3, SJR: 0.319, h-index: 15)
Advances in Atmospheric Sciences     Hybrid Journal   (Followers: 34, SJR: 0.959, h-index: 44)
Advances in Computational Mathematics     Hybrid Journal   (Followers: 15, SJR: 1.255, h-index: 44)
Advances in Contraception     Hybrid Journal   (Followers: 3)
Advances in Data Analysis and Classification     Hybrid Journal   (Followers: 51, SJR: 1.113, h-index: 14)
Advances in Gerontology     Partially Free   (Followers: 8, SJR: 0.141, h-index: 3)
Advances in Health Sciences Education     Hybrid Journal   (Followers: 22, SJR: 1.397, h-index: 42)
Advances in Manufacturing     Hybrid Journal   (Followers: 3, SJR: 0.2, h-index: 4)
Advances in Polymer Science     Hybrid Journal   (Followers: 41, SJR: 0.637, h-index: 89)
Advances in Therapy     Hybrid Journal   (Followers: 5, SJR: 0.79, h-index: 44)
Aegean Review of the Law of the Sea and Maritime Law     Hybrid Journal   (Followers: 7)
Aequationes Mathematicae     Hybrid Journal   (Followers: 2, SJR: 0.882, h-index: 23)
Aerobiologia     Hybrid Journal   (Followers: 1, SJR: 0.511, h-index: 36)
Aesthetic Plastic Surgery     Hybrid Journal   (Followers: 9, SJR: 0.821, h-index: 49)
African Archaeological Review     Hybrid Journal   (Followers: 15, SJR: 0.612, h-index: 24)
Afrika Matematika     Hybrid Journal   (Followers: 1, SJR: 0.248, h-index: 6)
AGE     Hybrid Journal   (Followers: 7, SJR: 1.358, h-index: 33)
Ageing Intl.     Hybrid Journal   (Followers: 7, SJR: 0.337, h-index: 10)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
Aging Clinical and Experimental Research     Hybrid Journal   (Followers: 3, SJR: 0.529, h-index: 55)
Agricultural Research     Hybrid Journal   (Followers: 3)
Agriculture and Human Values     Hybrid Journal   (Followers: 12, SJR: 1.197, h-index: 49)
Agroforestry Systems     Hybrid Journal   (Followers: 19, SJR: 0.64, h-index: 56)
Agronomy for Sustainable Development     Hybrid Journal   (Followers: 10, SJR: 1.732, h-index: 59)
AI & Society     Hybrid Journal   (Followers: 7, SJR: 0.171, h-index: 19)
AIDS and Behavior     Hybrid Journal   (Followers: 13, SJR: 2.006, h-index: 71)
Air Quality, Atmosphere & Health     Hybrid Journal   (Followers: 4, SJR: 0.706, h-index: 19)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Algebra and Logic     Hybrid Journal   (Followers: 4, SJR: 0.566, h-index: 18)
Algebra Universalis     Hybrid Journal   (Followers: 2, SJR: 0.388, h-index: 22)
Algebras and Representation Theory     Hybrid Journal   (Followers: 1, SJR: 0.868, h-index: 20)
Algorithmica     Hybrid Journal   (Followers: 8, SJR: 0.898, h-index: 56)
Allergo J.     Full-text available via subscription   (Followers: 1, SJR: 0.183, h-index: 20)
Allergo J. Intl.     Hybrid Journal   (Followers: 2)
Alpine Botany     Hybrid Journal   (Followers: 5, SJR: 0.729, h-index: 20)
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 3, SJR: 1.392, h-index: 32)
AMBIO     Hybrid Journal   (Followers: 15, SJR: 1.094, h-index: 87)
American J. of Cardiovascular Drugs     Hybrid Journal   (Followers: 16, SJR: 0.864, h-index: 39)
American J. of Community Psychology     Hybrid Journal   (Followers: 24, SJR: 1.237, h-index: 83)
American J. of Criminal Justice     Hybrid Journal   (Followers: 7, SJR: 0.634, h-index: 13)
American J. of Cultural Sociology     Hybrid Journal   (Followers: 12, SJR: 0.283, h-index: 3)
American J. of Dance Therapy     Hybrid Journal   (Followers: 4, SJR: 0.175, h-index: 13)
American J. of Potato Research     Hybrid Journal   (Followers: 2, SJR: 0.558, h-index: 35)
American J. of Psychoanalysis     Hybrid Journal   (Followers: 22, SJR: 0.293, h-index: 13)
American Sociologist     Hybrid Journal   (Followers: 14, SJR: 0.18, h-index: 13)
Amino Acids     Hybrid Journal   (Followers: 8, SJR: 1.362, h-index: 83)
AMS Review     Partially Free   (Followers: 4)
Analog Integrated Circuits and Signal Processing     Hybrid Journal   (Followers: 7, SJR: 0.21, h-index: 37)
Analysis and Mathematical Physics     Hybrid Journal   (Followers: 3, SJR: 0.665, h-index: 7)
Analysis in Theory and Applications     Hybrid Journal   (Followers: 1)
Analysis of Verbal Behavior     Hybrid Journal   (Followers: 5)
Analytical and Bioanalytical Chemistry     Hybrid Journal   (Followers: 30, SJR: 1.096, h-index: 123)
Anatomical Science Intl.     Hybrid Journal   (Followers: 2, SJR: 0.301, h-index: 26)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3, SJR: 2.212, h-index: 69)
Animal Cognition     Hybrid Journal   (Followers: 16, SJR: 1.122, h-index: 55)
Annales françaises de médecine d'urgence     Hybrid Journal   (Followers: 1, SJR: 0.156, h-index: 4)
Annales Henri Poincaré     Hybrid Journal   (Followers: 3, SJR: 1.377, h-index: 32)
Annales mathématiques du Québec     Hybrid Journal   (Followers: 4)
Annali dell'Universita di Ferrara     Hybrid Journal   (SJR: 0.504, h-index: 14)
Annali di Matematica Pura ed Applicata     Hybrid Journal   (Followers: 1, SJR: 1.167, h-index: 26)
Annals of Behavioral Medicine     Hybrid Journal   (Followers: 11, SJR: 2.112, h-index: 98)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18, SJR: 1.182, h-index: 94)
Annals of Combinatorics     Hybrid Journal   (Followers: 3, SJR: 0.849, h-index: 15)
Annals of Data Science     Hybrid Journal   (Followers: 11)
Annals of Dyslexia     Hybrid Journal   (Followers: 9, SJR: 0.857, h-index: 40)
Annals of Finance     Hybrid Journal   (Followers: 28, SJR: 0.686, h-index: 14)
Annals of Forest Science     Hybrid Journal   (Followers: 6, SJR: 0.929, h-index: 57)
Annals of Global Analysis and Geometry     Hybrid Journal   (Followers: 1, SJR: 1.136, h-index: 23)
Annals of Hematology     Hybrid Journal   (Followers: 14, SJR: 1.117, h-index: 62)
Annals of Mathematics and Artificial Intelligence     Hybrid Journal   (Followers: 7, SJR: 0.593, h-index: 42)
Annals of Microbiology     Hybrid Journal   (Followers: 10, SJR: 0.402, h-index: 26)
Annals of Nuclear Medicine     Hybrid Journal   (Followers: 5, SJR: 0.68, h-index: 45)
Annals of Operations Research     Hybrid Journal   (Followers: 8, SJR: 1.186, h-index: 78)
Annals of Ophthalmology     Hybrid Journal   (Followers: 12)
Annals of Regional Science     Hybrid Journal   (Followers: 7, SJR: 0.405, h-index: 42)
Annals of Software Engineering     Hybrid Journal   (Followers: 12)
Annals of Solid and Structural Mechanics     Hybrid Journal   (Followers: 10, SJR: 0.553, h-index: 8)
Annals of Surgical Oncology     Hybrid Journal   (Followers: 16, SJR: 1.902, h-index: 127)
Annals of Telecommunications     Hybrid Journal   (Followers: 7, SJR: 0.315, h-index: 25)
Annals of the Institute of Statistical Mathematics     Hybrid Journal   (Followers: 1, SJR: 0.931, h-index: 31)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 5, SJR: 0.992, h-index: 87)
Apidologie     Hybrid Journal   (Followers: 4, SJR: 1.14, h-index: 57)
APOPTOSIS     Hybrid Journal   (Followers: 8, SJR: 1.554, h-index: 87)
Applicable Algebra in Engineering, Communication and Computing     Hybrid Journal   (Followers: 2, SJR: 0.354, h-index: 27)
Applications of Mathematics     Hybrid Journal   (Followers: 1, SJR: 0.274, h-index: 20)
Applied Biochemistry and Biotechnology     Hybrid Journal   (Followers: 44, SJR: 0.575, h-index: 80)
Applied Biochemistry and Microbiology     Hybrid Journal   (Followers: 17, SJR: 0.267, h-index: 26)
Applied Cancer Research     Open Access  
Applied Categorical Structures     Hybrid Journal   (Followers: 2, SJR: 0.361, h-index: 21)
Applied Composite Materials     Hybrid Journal   (Followers: 48, SJR: 0.705, h-index: 35)
Applied Entomology and Zoology     Partially Free   (Followers: 3, SJR: 0.554, h-index: 34)
Applied Geomatics     Hybrid Journal   (Followers: 3, SJR: 0.323, h-index: 9)
Applied Geophysics     Hybrid Journal   (Followers: 8, SJR: 0.541, h-index: 13)
Applied Intelligence     Hybrid Journal   (Followers: 11, SJR: 0.777, h-index: 43)
Applied Magnetic Resonance     Hybrid Journal   (Followers: 4, SJR: 0.358, h-index: 34)
Applied Mathematics & Optimization     Hybrid Journal   (Followers: 4, SJR: 0.955, h-index: 33)
Applied Mathematics - A J. of Chinese Universities     Hybrid Journal   (SJR: 0.275, h-index: 8)
Applied Mathematics and Mechanics     Hybrid Journal   (Followers: 5, SJR: 0.37, h-index: 26)
Applied Microbiology and Biotechnology     Hybrid Journal   (Followers: 62, SJR: 1.262, h-index: 161)
Applied Physics A     Hybrid Journal   (Followers: 7, SJR: 0.535, h-index: 121)
Applied Physics B: Lasers and Optics     Hybrid Journal   (Followers: 23, SJR: 0.983, h-index: 104)
Applied Psychophysiology and Biofeedback     Hybrid Journal   (Followers: 8, SJR: 0.677, h-index: 47)
Applied Research in Quality of Life     Hybrid Journal   (Followers: 11, SJR: 0.288, h-index: 15)
Applied Solar Energy     Hybrid Journal   (Followers: 17, SJR: 0.251, h-index: 6)
Applied Spatial Analysis and Policy     Hybrid Journal   (Followers: 4, SJR: 0.351, h-index: 9)
Aquaculture Intl.     Hybrid Journal   (Followers: 22, SJR: 0.613, h-index: 40)
Aquarium Sciences and Conservation     Hybrid Journal   (Followers: 1)
Aquatic Ecology     Hybrid Journal   (Followers: 32, SJR: 0.646, h-index: 44)
Aquatic Geochemistry     Hybrid Journal   (Followers: 4, SJR: 0.764, h-index: 39)
Aquatic Sciences     Hybrid Journal   (Followers: 13, SJR: 1.172, h-index: 53)
Arabian J. for Science and Engineering     Hybrid Journal   (Followers: 5, SJR: 0.345, h-index: 20)
Arabian J. of Geosciences     Hybrid Journal   (Followers: 1, SJR: 0.417, h-index: 16)
Archaeological and Anthropological Sciences     Hybrid Journal   (Followers: 23, SJR: 1.056, h-index: 15)
Archaeologies     Hybrid Journal   (Followers: 12, SJR: 0.397, h-index: 13)
Archiv der Mathematik     Hybrid Journal   (Followers: 1, SJR: 0.597, h-index: 29)
Archival Science     Hybrid Journal   (Followers: 56, SJR: 0.804, h-index: 22)
Archive for History of Exact Sciences     Hybrid Journal   (Followers: 8, SJR: 0.28, h-index: 15)
Archive for Mathematical Logic     Hybrid Journal   (Followers: 1, SJR: 0.946, h-index: 23)
Archive for Rational Mechanics and Analysis     Hybrid Journal   (SJR: 4.091, h-index: 66)
Archive of Applied Mechanics     Hybrid Journal   (Followers: 5, SJR: 0.865, h-index: 40)
Archives and Museum Informatics     Hybrid Journal   (Followers: 131)
Archives of Computational Methods in Engineering     Hybrid Journal   (Followers: 4, SJR: 2.841, h-index: 40)
Archives of Dermatological Research     Hybrid Journal   (Followers: 7, SJR: 0.9, h-index: 65)
Archives of Environmental Contamination and Toxicology     Hybrid Journal   (Followers: 11, SJR: 0.846, h-index: 84)
Archives of Gynecology and Obstetrics     Hybrid Journal   (Followers: 17, SJR: 0.695, h-index: 47)
Archives of Microbiology     Hybrid Journal   (Followers: 8, SJR: 0.702, h-index: 85)
Archives of Orthopaedic and Trauma Surgery     Hybrid Journal   (Followers: 8, SJR: 1.039, h-index: 56)
Archives of Osteoporosis     Hybrid Journal   (Followers: 2, SJR: 1.092, h-index: 13)
Archives of Sexual Behavior     Hybrid Journal   (Followers: 9, SJR: 1.198, h-index: 74)
Archives of Toxicology     Hybrid Journal   (Followers: 16, SJR: 1.595, h-index: 76)
Archives of Virology     Hybrid Journal   (Followers: 5, SJR: 1.086, h-index: 90)
Archives of Women's Mental Health     Hybrid Journal   (Followers: 14, SJR: 1.264, h-index: 50)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2, SJR: 1.2, h-index: 42)
ArgoSpine News & J.     Hybrid Journal   (SJR: 0.102, h-index: 3)
Argumentation     Hybrid Journal   (Followers: 5, SJR: 0.295, h-index: 18)
Arid Ecosystems     Hybrid Journal   (Followers: 3)
Arkiv för Matematik     Hybrid Journal   (Followers: 1, SJR: 0.948, h-index: 22)
Arnold Mathematical J.     Hybrid Journal   (Followers: 1)
Arthropod-Plant Interactions     Hybrid Journal   (Followers: 2, SJR: 0.797, h-index: 17)
Arthroskopie     Hybrid Journal   (Followers: 1, SJR: 0.145, h-index: 8)
Artificial Intelligence and Law     Hybrid Journal   (Followers: 10, SJR: 0.288, h-index: 25)
Artificial Intelligence Review     Hybrid Journal   (Followers: 14, SJR: 0.948, h-index: 48)
Artificial Life and Robotics     Hybrid Journal   (Followers: 8, SJR: 0.231, h-index: 14)
Asia Europe J.     Hybrid Journal   (Followers: 5, SJR: 0.247, h-index: 9)
Asia Pacific Education Review     Hybrid Journal   (Followers: 12, SJR: 0.371, h-index: 17)
Asia Pacific J. of Management     Hybrid Journal   (Followers: 15, SJR: 1.676, h-index: 50)
Asia-Pacific Education Researcher     Hybrid Journal   (Followers: 12, SJR: 0.353, h-index: 13)
Asia-Pacific Financial Markets     Hybrid Journal   (Followers: 2, SJR: 0.19, h-index: 15)
Asia-Pacific J. of Atmospheric Sciences     Hybrid Journal   (Followers: 20, SJR: 1.006, h-index: 14)
Asian Business & Management     Hybrid Journal   (Followers: 8, SJR: 0.41, h-index: 10)
Asian J. of Business Ethics     Hybrid Journal   (Followers: 7)
Asian J. of Criminology     Hybrid Journal   (Followers: 5, SJR: 0.263, h-index: 8)
AStA Advances in Statistical Analysis     Hybrid Journal   (Followers: 2, SJR: 0.681, h-index: 15)
AStA Wirtschafts- und Sozialstatistisches Archiv     Hybrid Journal   (Followers: 5, SJR: 0.195, h-index: 5)
ästhetische dermatologie & kosmetologie     Full-text available via subscription  

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Journal Cover Allergo Journal International
  [2 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Online) 2197-0378
   Published by Springer-Verlag Homepage  [2352 journals]
  • Correction to: Abstracts of the 12th German Allergy Congress
    • Authors: Marion Weber
      Pages: 283 - 283
      Abstract: Correction to: Allergo J Int 2017 https://doi.org/10.1007/s40629-017-0036-9 The original article has been corrected. Erroneously, in the online html article “abstract” was given as article …
      PubDate: 2017-11-01
      DOI: 10.1007/s40629-017-0038-7
      Issue No: Vol. 26, No. 7 (2017)
       
  • Abridged version of the AWMF guideline for the medical clinical
           diagnostics of indoor mould exposure
    • Authors: Gerhard A. Wiesmüller; Birger Heinzow; Ute Aurbach; Karl-Christian Bergmann; Albrecht Bufe; Walter Buzina; Oliver A. Cornely; Steffen Engelhart; Guido Fischer; Thomas Gabrio; Werner Heinz; Caroline E. W. Herr; Jörg Kleine-Tebbe; Ludger Klimek; Martin Köberle; Herbert Lichtnecker; Thomas Lob-Corzilius; Rolf Merget; Norbert Mülleneisen; Dennis Nowak; Uta Rabe; Monika Raulf; Hans Peter Seidl; Jens-Oliver Steiß; Regine Szewszyk; Peter Thomas; Kerttu Valtanen; Julia Hurraß
      Pages: 168 - 193
      Abstract: This article is an abridged version of the AWMF mould guideline “Medical clinical diagnostics of indoor mould exposure” presented in April 2016 by the German Society of Hygiene, Environmental Medicine and Preventive Medicine (Gesellschaft für Hygiene, Umweltmedizin und Präventivmedizin, GHUP), in collaboration with the above-mentioned scientific medical societies, German and Austrian societies, medical associations and experts. Indoor mould growth is a potential health risk, even if a quantitative and/or causal relationship between the occurrence of individual mould species and health problems has yet to be established. Apart from allergic bronchopulmonary aspergillosis (ABPA) and mould-caused mycoses, only sufficient evidence for an association between moisture/mould damage and the following health effects has been established: allergic respiratory disease, asthma (manifestation, progression and exacerbation), allergic rhinitis, hypersensitivity pneumonitis (extrinsic allergic alveolitis), and increased likelihood of respiratory infections/bronchitis. In this context the sensitizing potential of moulds is obviously low compared to other environmental allergens. Recent studies show a comparatively low sensitizing prevalence of 3–10% in the general population across Europe. Limited or suspected evidence for an association exist with respect to mucous membrane irritation and atopic eczema (manifestation, progression and exacerbation). Inadequate or insufficient evidence for an association exist for chronic obstructive pulmonary disease, acute idiopathic pulmonary hemorrhage in children, rheumatism/arthritis, sarcoidosis and cancer. The risk of infection posed by moulds regularly occurring indoors is low for healthy persons; most species are in risk group 1 and a few in risk group 2 (Aspergillus fumigatus, A. flavus) of the German Biological Agents Act (Biostoffverordnung). Only moulds that are potentially able to form toxins can be triggers of toxic reactions. Whether or not toxin formation occurs in individual cases is determined by environmental and growth conditions, above all the substrate. In the case of indoor moisture/mould damage, everyone can be affected by odour effects and/or mood disorders. However, this is not a health hazard. Predisposing factors for odour effects can include genetic and hormonal influences, imprinting, context and adaptation effects. Predisposing factors for mood disorders may include environmental concerns, anxiety, condition, and attribution, as well as various diseases. Risk groups to be protected particularly with regard to an infection risk are persons on immunosuppression according to the classification of the German Commission for Hospital Hygiene and Infection Prevention (Kommission für Krankenhaushygiene und Infektionsprävention, KRINKO) at the Robert Koch- Institute (RKI) and persons with cystic fibrosis (mucoviscidosis); with regard to an allergic risk, persons with cystic fibrosis (mucoviscidosis) and patients with bronchial asthma should be protected. The rational diagnostics include the medical history, physical examination, and conventional allergy diagnostics including provocation tests if necessary; sometimes cellular test systems are indicated. In the case of mould infections the reader is referred to the AWMF guideline “Diagnosis and Therapy of Invasive Aspergillus Infections”. With regard to mycotoxins, there are currently no useful and validated test procedures for clinical diagnostics. From a preventive medicine standpoint it is important that indoor mould infestation in relevant dimension cannot be tolerated for precautionary reasons. With regard to evaluating the extent of damage and selecting a remedial procedure, the reader is referred to the revised version of the mould guideline issued by the German Federal Environment Agency (Umweltbundesamt, UBA).
      PubDate: 2017-08-01
      DOI: 10.1007/s40629-017-0013-3
      Issue No: Vol. 26, No. 5 (2017)
       
  • New trends in anaphylaxis
    • Authors: Margitta Worm; Gunter Sturm; Jörg Kleine-Tebbe; Ewa Cichocka-Jarosz; Victoria Cardona; Ioana Maris; Sabine Dölle
      Abstract: This review presents the current trends in anaphylaxis management discussed at the fourth International Network for Online-Registration of Anaphylaxis (NORA) conference held in Berlin in April 2017. Current data from the anaphylaxis registry show that Hymenoptera venom, foods, and pharmaceutical drugs are still among the most frequent triggers of anaphylaxis. Rare triggers include chicory, cardamom, asparagus, and goji berries. A meta-analysis on recent trends in insect venom anaphylaxis demonstrated for the first time that, although data on the efficacy of insect venom immunotherapy is limited, the occurrence of severe reactions upon repeated sting events can be prevented and patients’ quality of life improved. Molecular diagnostics of insect venom anaphylaxis have significantly improved diagnostic sensitivity and specificity. Self-treatment of anaphylaxis is of great importance. Recent data from the anaphylaxis registry show an increase (from 23% in 2012 to 29% in 2016) in the use of adrenaline as recommended in the guidelines. A survey on the implementation of guidelines conducted among the centers reporting to the anaphylaxis registry highlights the extent to which the guideline has been perceived and implemented. Reports on a variety of cases in the anaphylaxis registry illustrate the diversity of this potentially life-threatening reaction. Component-resolved diagnostics can help to specify sensitization profiles in anaphylaxis, particularly in terms of the risk for severe reactions. Recent studies on anaphylaxis awareness show that training methods are effective; nevertheless, target groups and learning methods need to undergo further scientific investigation in coming years.
      PubDate: 2017-11-15
      DOI: 10.1007/s40629-017-0042-y
       
  • Bird-egg syndrome: a variant of secondary food allergies
    • Authors: Sarah Trame; Stefani Röseler; David Kluwig; Cathleen Schreiter; Janina Staub; Gerda Wurpts; Hans F. Merk; Jens M. Baron
      PubDate: 2017-09-22
      DOI: 10.1007/s40629-017-0035-x
       
  • The benefit of molecular diagnostics in allergic rhinitis
    • Authors: Sven Becker; Moritz Gröger; Thilo Jakob; Ludger Klimek
      Abstract: Background Molecular component-resolved diagnostics has established itself in recent years as an integral part of the routine diagnosis of allergic rhinitis. Methods A systematic literature review was performed. Results By using allergen components appropriately, it is possible to identify IgE sensitizations to specific marker allergens and to crossreactive allergens and this way explain polysensitizations obtained in extract-based diagnostics. The detection of individual molecular sensitization patterns enables better classification of the clinical symptoms, thus enhancing the possibility of individual, personalized treatment planning. This implies greater diagnostic reliability for specific immunotherapy, which should in turn result in a better treatment response—despite there being no scientific evidence of this as yet. Discussion In spite of the immense expansion of our knowledge in the field of component-resolved diagnostics, the clinical relevance of molecular findings still needs to be consistently assessed on the basis of the individual patient’s symptoms. This paper is intended to provide a guide to—and highlight possible courses of action when—making appropriate use of individual components in the diagnosis of allergic rhinitis.
      PubDate: 2017-09-18
      DOI: 10.1007/s40629-017-0033-z
       
  • Current concepts in eosinophilic esophagitis
    • Authors: Dagmar Simon; Alex Straumann; Alain M. Schoepfer; Hans-Uwe Simon
      Abstract: Background Eosinophilic esophagitis (EoE) is a disease entity first described in the 1990s, but showing an increasing incidence that is characterized clinically by esophageal dysfunction and histologically by a striking eosinophil infiltration. Methods This article discusses new aspects of the pathogenesis, symptoms, diagnosis, and treatment of EoE. Results EoE affects both children and adults and is frequently associated with atopic disease and IgE sensitization. Barrier dysfunction and T‑helper 2 inflammation are considered to be pathogenetically important factors. Recently, a proton pump inhibitor (PPI)-sensitive EoE subtype as well as an EoE-like disorder have been described. Conclusion Research in recent years has contributed to a better understanding of the disease spectrum and pathogenesis of EoE, including genetic dispositions, thereby laying the foundation for innovative treatment approaches.
      PubDate: 2017-09-13
      DOI: 10.1007/s40629-017-0037-8
       
  • abstracts
    • PubDate: 2017-09-11
      DOI: 10.1007/s40629-017-0036-9
       
  • The pollator: a personal pollen sampling device
    • Authors: Matthias Werchan; Torsten Sehlinger; Frank Goergen; Karl-Christian Bergmann
      PubDate: 2017-08-30
      DOI: 10.1007/s40629-017-0034-y
       
  • New aspects in allergy education with special emphasis on anaphylaxis
    • Authors: Johannes Ring; Knut Brockow; Claudia Kugler; Norbert Gebert; Karin Grando; Doris Götz; Isidor Hutegger; Hannes Lüthi; Daniela Münch; Thomas Spindler; Peter Schmid-Grendelmeier; Uwe Gieler
      Abstract: Background Interdisciplinary anaphylaxis education programs have been performed in Germany and Austria since 2007 according to the program of the Working Group on Anaphylaxis Training and Education (AGATE, “Arbeitsgemeinschaft Anaphylaxie Training und Edukation”), as well as in Switzerland with similar content. The basic units of education have been developed from a standardized guideline-based manual, which is continuously updated and is currently being converted into a modular system. Methods In June 2016, an expert meeting took place in Davos, Switzerland, under the auspices of the Christine Kühne Center for Allergy Research and Education (CK-CARE), bringing together experts from Germany, Austria, and Switzerland with the aim of developing new concepts in allergy education. Results Supplementary online modules were discussed as new avenues in didactics and methodology. The electronic content of these modules is in the process of being formulated and existing websites are being adapted. In terms of content, the topic “anxiety” needs to be included, and guidance for an individualized risk-management strategy for patients would appear important. New target groups for anaphylaxis seminars (apart from physicians/nurses, other healthcare personnel, and non-medical health occupations such as pharmacists) include carers, teachers, and nursery school teachers.
      PubDate: 2017-08-30
      DOI: 10.1007/s40629-017-0032-0
       
  • Current diagnostics in NSAID hypersensitivity
    • Authors: Bettina Wedi
      Abstract: Non-steroidal anti-inflammatory drugs (NSAID) are the second most common trigger of drug hypersensitivity in adults and children and are considered the most common or second most common cause of drug-induced anaphylaxis. NSAID hypersensitivity reactions are classified according to the latency of symptoms in relation to ingestion and on the basis of symptoms, potential underlying disease (chronic urticaria, bronchial asthma/chronic rhinosinusitis/nasal polyps), cross-reactivity to other NSAID, and the suspected pathomechanism. The diagnosis and management of NSAID hypersensitivity depend on the confirmed or suspected type of reaction. The pathomechanism for the majority of hypersensitivity reactions to NSAID has not been elucidated in detail; preferential COX-1 inhibition, which causes a shift in arachidonic acid metabolism, is considered relevant to an extent in immediate-type reactions. Delayed reactions to NSAID are rarer, diverse, and considered to be T cell mediated. All NSAIDs are essentially able to trigger all types of reaction. Immediate-type reactions involving cutaneous (urticaria/angioedema) and/or respiratory symptoms (rhinitis, bronchial asthma), as well as anaphylactic reactions are the most common. A careful allergy diagnostic work-up enables hypersensitivity to be excluded in the majority of affected individuals. In vitro testing and skin testing, as well as the gold standard, provocation testing with the suspected NSAID, or exposure testing to identify safe alternatives are used in a stepwise approach. It is important to bear in mind that standardized and validated in vitro test methods (e. g., specific IgE determination, basophil activation test, lymphocyte transformation test) and skin testing are not available for most NSAID and often prove negative. Except in the case of severe index reactions, provocation testing (with emergency response measures in place) to establish the diagnosis, evaluate possible cross-reactivity, and identify safe alternatives should be performed. Avoidance measures should only be recommended if the diagnosis has been reliably established. Patients should receive recommendations (avoidance measures, alternatives) in written form.
      PubDate: 2017-08-22
      DOI: 10.1007/s40629-017-0030-2
       
  • Long-term efficacy of specific subcutaneous, short-term MPL adjuvant
           immunotherapy over three treatment and three follow-up years, as measured
           by quality of life
    • Authors: Uta Rabe; Julia Altengarten; Erhard Benke; Anja Erdmann; Alf-Peter Erdmann; Gabriela Fiedler; Siegrid Hofmann; Birgit Jasch; Ute Kallien; Sabine Knuppe-Andree; Hans-Joachim Lüdcke; Kathrin Lohse; Monika Piller
      Abstract: Background Apart from allergen avoidance, specific immunotherapy (SIT) is the only causal treatment for pollen allergy diseases. Its efficacy and tolerability have been demonstrated in numerous studies on adults and children. There are fewer studies, however, evidencing a long-term treatment effect and the effect of treatment on patients’ quality of life (QoL). Patients and methods The aim of this prospective, noninterventional postmarketing surveillance (PMS) study was to document QoL with, and long-term effect of, an MPL (monophosphoryl lipid A)-adjuvanted allergoid involving four injections over 3 treatment years and 3 follow-up years. In the period from 2006–2012, 223 pollen-allergic individuals from 12 centers were evaluated annually. The patients completed standardized questionnaires on QoL for each pollen season. Symptoms documented in the QoL questionnaire were temporally aligned with data from regional pollen traps. Results Patients with allergy to pollen from early bloomers (birch, alder, hazel), as well as patients with grass/rye allergy, showed a continuous improvement in treatment effect over the 3 treatment years and a good carry-over effect in follow-up years 1–3. Conclusion Short-term MPL adjuvant therapy showed good efficacy at 3 years following treatment completion and is suited to the long-term improvement of patient QoL.
      PubDate: 2017-07-25
      DOI: 10.1007/s40629-017-0029-8
       
  • Psychogenic nonepileptic seizure (PNES) mimicking acute anaphylactic
           reaction
    • Authors: Azadeh Tajmir-Riahi; Vera Mahler
      PubDate: 2017-06-08
      DOI: 10.1007/s40629-017-0028-9
       
  • Course of respiratory allergy by treatment strategy based on German
           routine data
    • Authors: Ann-Kathrin Weschenfelder; Ludger Klimek; Norbert Mülleneisen; Harald Renz; Wolfgang Wehrmann; Thomas Werfel; Eckard Hamelmann; Jürgen Wasem; Janine Biermann
      Abstract: Purpose Allergic respiratory diseases represent a global health problem. The two major treatment strategies are symptom treatment and specific immunotherapy (SIT). SIT is considered the only causal treatment option available with the ability to alter the course of the disease. This study aims to describe the course of disease and medication of respiratory allergy across treatment strategies and disease groups. Methods The analysis is based on routine data from a German statutory health insurance. The patient cohort is observed from 2007–2012. For each year based on assured outpatient diagnoses patients are assigned to a disease group: rhinitis, asthma or both diseases. Additionally, prescribed medication is considered. Treatment comparisons are based on matched pairs. Results The study population comprises 165,446 patients with respiratory allergy. In 2007 the most frequent disease group is rhinitis (70%), followed by asthma (16%) and both diseases (14%). During the observation period a second allergic respiratory diagnosis occurs only in about 12% of rhinitis patients and 28% of asthma patients. In about 50% of patients with both diseases one of the diagnoses is omitted. These patients are more likely to no longer report their asthma diagnosis when receiving immunotherapy compared to symptom treatment. Furthermore immunotherapy reduces the frequency of asthma medication use. Conclusions Results of detailed analysis of diagnoses reflect the alternating nature of allergic diseases. Although limited by accuracy of documentation and the lack of clinical information, the comparison of treatment strategies shows some advantages of immunotherapy regarding course of disease and asthma medication use.
      PubDate: 2017-05-30
      DOI: 10.1007/s40629-017-0027-x
       
  • Insects and arachnids as elicitors of toxic and allergic reactions in
           Germany
    • Authors: Randolf Brehler
      Abstract: Background Bees and wasps are the main culprits in terms of severe allergic reactions to insects in Germany; venoms from both insects are available for specific immunotherapy (SIT). Therefore, it is important to differentiate reactions to venom from other animals. It is also necessary for the sake of targeted prevention to assign sting reactions of any kind to their causal agents. Methods By searching Medline, it was possible to identify relevant elicitors of sting and bite reactions particularly in Germany and Europe. Results Not only Hymenoptera stings, but also bites and stings from other insects, as well as skin contact with insect components, can cause allergic and/or toxic skin reactions. Mosquitoes, horseflies, and thrips cause local reactions. Contact with some beetles may lead to blister formation and skin inflammation. Bed bugs are becoming an increasing problem in Germany too, and introduction into the domestic environment via luggage is possible. Although spider bites can also cause reactions in humans in Germany, reactions to lice and flea bites are more common. Some caterpillars have hair and bristles that act as a defense mechanism and cause not only skin reactions, but also respiratory reactions, including asthma attacks. Ants, particularly in the US and Australia, are relevant triggers of anaphylactic reactions. Conclusion Hymenoptera stings are the most common cause of systemic allergic reactions, while ants also need to be borne in mind in tropical and subtropical countries. Other insects rarely cause anaphylactic reactions. In this part of the world, numerous other insects may be the cause of local sting reactions.
      PubDate: 2017-05-23
      DOI: 10.1007/s40629-017-0026-y
       
  • Allergic reactions to antibiotics – two sides of the same coin: clearly
           diagnose or reliably rule out
    • Authors: Ludger Klimek; Christoph Aderhold; Annette Sperl; Axel Trautmann
      Abstract: Background Antibiotics cause allergic reactions with a disproportionate frequency compared with other drugs. Skin symptoms such as exanthema usually result but systemic anaphylactic responses may also occur. Materials and methods An up-to-date review of the scientific literature on allergies to antibiotics was conducted, based on searches in MEDLINE and PubMed, as well as national and international guideline registers and Cochrane. Results Allergic reactions are observed primarily in response to antibiotics from the group of β‑lactams, but also to clindamycin, sulfonamide antibiotics, fluorochinolones, macrolides, and tetracyclines. In many cases, detailed diagnostic procedures are not carried out. However, claims made in the medical history alone are often insufficient to diagnose antibiotics allergy and may lead to false-positive assessments. Effective antibiotics are, therefore, frequently withheld from patients – or patients refuse to take them – without justification. For example, up to 10% of the whole population claim to be allergic to penicillin, but in only 2% of cases can this be verified by skin tests and challenge testing. Conclusions Thorough diagnostic investigation of possible allergy to antibiotics both allows antibiotic allergy to be reliably diagnosed (in the event of a positive outcome) and, if the results are negative, enables the further use of major groups of antibiotics. It also helps to reduce the unnecessary application of reserve antibiotics.
      PubDate: 2017-05-22
      DOI: 10.1007/s40629-017-0025-z
       
  • Pollen-related food allergy: an update
    • Authors: Regina Treudler; Jan-Christoph Simon
      Abstract: Background The vast majority of IgE-mediated food allergies in adults are based on sensitization to pollen, followed by reactions to structurally related, often unstable allergens, in particular in fruit (including edible nuts), vegetables, and spices. Materials and methods This article provides an up-to-date overview of selected scientific works on pollen-related food allergy and has been drawn-up on the basis of PubMed research, the German Study on Adult Health (Studie zur Gesundheit Erwachsener in Deutschland, DEGS) conducted by the Robert Koch Institute, as well as the national and international guideline registries. Results Birch pollen-related symptoms are generally the commonest form of pollen-related allergy observed in Northern Europe. The types of fruit that most frequently cause symptoms belong to the Rosaceae (e. g., apple, cherry) and Fagales families (hazelnut). Reactions to legumes (e. g., peanut, soy) and vegetables, including celery, carrot, tomato, and bell pepper, are also worthy of note. In addition to oropharyngeal contact urticaria, the clinical symptoms of pollen-related food allergy can range from the involvement of other organ systems to anaphylactic shock. The main plant food allergens belong to a handful of protein families: Bet v 1 homologs, profilins, lipid transfer proteins, storage proteins, and thaumatin-like proteins. Conclusion The diagnosis of pollen-related food allergy has seen significant advances in recent years in the wake of component-resolved/molecular allergology, thereby, enabling reliable identification. Treatment comprises dietary counseling and the prescription of emergency medication. In addition, allergen-specific immunotherapy for cross-reactive pollen allergens appears to positively affect concomitant food allergies in some patients.
      PubDate: 2017-05-05
      DOI: 10.1007/s40629-017-0022-2
       
  • The small liver fluke ( Dicrocoelium dendriticum ): an unusual clinical
           finding in chronic urticaria
    • Authors: Carolin Blatner; Eva Maria Oppel; Andreas Wieser; Thomas Herzinger; Franziska Ruëff
      PubDate: 2017-05-04
      DOI: 10.1007/s40629-017-0021-3
       
  • Dealing with absolute and relative contraindications to specific
           immunotherapy using Hymenoptera venoms
    • Authors: Andrea Bauer; Franziska Ruëff
      Abstract: Background Acute infectious disorders, uncontrolled bronchial asthma, severe chronic inflammatory disorders, severe cardiovascular disorders, autoimmune or immunodeficiency disorders, active or progressive cancer, acquired immunodeficiency syndrome (AIDS), treatment initiation during pregnancy, as well as medication with β‑blockers and angiotensin-converting enzyme (ACE) inhibitors, among others, are considered either absolute or relative contraindications to specific immunotherapy using Hymenoptera venom (HV-SIT). Some of the contraindications listed above, however, are potential risk factors in the event of anaphylaxis, such that one regularly needs to challenge these contraindications on a case-by-case basis so as not to withhold HV-SIT from patients at particularly high risk. Methods Literature review. Results and conclusion Study data on a risk-increasing effect are available for only some of the contraindications to HV-SIT listed in the product information or guidelines. Moreover, these data are partially conflicting. Nevertheless, acute infectious disorders, active autoimmune disorders during flare-ups, active or progressive malignant disease, uncontrolled bronchial asthma, AIDS, and treatment during pregnancy are considered absolute contraindications to the initiation of HV-SIT. Some of these contraindications are, by their very nature, temporary. In other cases, therapy can be initiated once the underlying disease has been optimally treated. Relative contraindications to the initiation of HV-SIT include autoimmune disorders in remission, immune defects and immunosuppressive therapy, well-controlled chronic infectious diseases, category A and B HIV, partially controlled bronchial asthma, limited compliance, age below 5 years, cancer in remission, comedication with ACE inhibitors and β‑blockers, as well as treatment (continuation) during pregnancy. In the case of relative as well as absolute contraindications, it is essential to conduct a risk/benefit analysis prior to initiating or continuing HV-SIT.
      PubDate: 2017-05-04
      DOI: 10.1007/s40629-017-0024-0
       
  • Bee venom allergy: a recent trend among amateur beekeepers
    • Authors: Gwendolyn Dinkel; Katharina Pietschke; Katharina Belge; Amir Yazdi; Jörg Fischer
      PubDate: 2017-03-24
      DOI: 10.1007/s40629-017-0018-y
       
  • Birch, grass, and mugwort pollen concentrations and intradiurnal patterns
           at two different urban sites in Berlin, Germany
    • Authors: Anke Simoleit; Matthias Werchan; Barbora Werchan; Hans-Guido Mücke; Ulrich Gauger; Torsten Zuberbier; Karl-Christian Bergmann
      Abstract: Purpose The study investigated the seasonal courses and intradiurnal patterns of birch (Betula), grass (Poaceae), and mugwort (Artemisia) pollen at two sites in the city of Berlin in 2014 and 2015. Methods The “Motorway Site” was situated at a busy city motorway and the “City Center Site” on the roof of a large hospital. Sampling was undertaken with 7‑day recording volumetric spore traps. Light microscopic analysis led to daily means (pollen/m3 air) and 2‑h means (daily %). Correlation coefficients were calculated to compare pollen season between the sites. Rainless days were examined for their intradiurnal maximum of pollen concentration and corresponding wind direction in order to identify the impact of local pollen sources. Birch trees, grassed areas, and mugwort/field sagewort stems were mapped at both sites. Results The seasonal courses of Betula, Poaceae, and Artemisia pollen each showed significantly positive correlations between the sites, but absolute counts were higher at the motorway. Artemisia pollen showed a distinct morning profile at both sites. Poaceae pollen concentrated on the second half of the day peaking in the evening or at night. Betula pollen offered no clear trend, but the main period mostly started at 8 am and lasted until the end of day. Conclusions Higher pollen counts at the motorway seem to be associated with the local vegetation that was much more abundant than at the city center. Local sources of weeds (Artemisia) and grasses (Poaceae) releasing pollen at low heights appear to be more contributing for local pollen load than trees (Betula) at these sites.
      PubDate: 2017-03-15
      DOI: 10.1007/s40629-017-0012-4
       
 
 
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