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Publisher: Springer-Verlag (Total: 2574 journals)

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Showing 1 - 200 of 2574 Journals sorted alphabetically
3D Printing in Medicine     Open Access   (Followers: 4)
3D Research     Hybrid Journal   (Followers: 21, SJR: 0.222, CiteScore: 1)
4OR: A Quarterly J. of Operations Research     Hybrid Journal   (Followers: 11, SJR: 0.825, CiteScore: 1)
AAPS J.     Hybrid Journal   (Followers: 29, SJR: 1.118, CiteScore: 4)
AAPS PharmSciTech     Hybrid Journal   (Followers: 8, SJR: 0.752, CiteScore: 3)
Abdominal Radiology     Hybrid Journal   (Followers: 18, SJR: 0.866, CiteScore: 2)
Abhandlungen aus dem Mathematischen Seminar der Universitat Hamburg     Hybrid Journal   (Followers: 4, SJR: 0.439, CiteScore: 0)
Academic Psychiatry     Full-text available via subscription   (Followers: 30, SJR: 0.53, CiteScore: 1)
Academic Questions     Hybrid Journal   (Followers: 9, SJR: 0.106, CiteScore: 0)
Accreditation and Quality Assurance: J. for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 31, SJR: 0.316, CiteScore: 1)
Acoustical Physics     Hybrid Journal   (Followers: 11, SJR: 0.359, CiteScore: 1)
Acoustics Australia     Hybrid Journal   (Followers: 1, SJR: 0.232, CiteScore: 1)
Acta Analytica     Hybrid Journal   (Followers: 7, SJR: 0.367, CiteScore: 0)
Acta Applicandae Mathematicae     Hybrid Journal   (Followers: 1, SJR: 0.675, CiteScore: 1)
Acta Biotheoretica     Hybrid Journal   (Followers: 4, SJR: 0.284, CiteScore: 1)
Acta Diabetologica     Hybrid Journal   (Followers: 19, SJR: 1.587, CiteScore: 3)
Acta Endoscopica     Hybrid Journal   (Followers: 1)
acta ethologica     Hybrid Journal   (Followers: 4, SJR: 0.769, CiteScore: 1)
Acta Geochimica     Hybrid Journal   (Followers: 7, SJR: 0.24, CiteScore: 1)
Acta Geodaetica et Geophysica     Hybrid Journal   (Followers: 3, SJR: 0.305, CiteScore: 1)
Acta Geophysica     Hybrid Journal   (Followers: 11, SJR: 0.312, CiteScore: 1)
Acta Geotechnica     Hybrid Journal   (Followers: 7, SJR: 1.588, CiteScore: 3)
Acta Informatica     Hybrid Journal   (Followers: 5, SJR: 0.517, CiteScore: 1)
Acta Mathematica     Hybrid Journal   (Followers: 12, SJR: 7.066, CiteScore: 3)
Acta Mathematica Hungarica     Hybrid Journal   (Followers: 2, SJR: 0.452, CiteScore: 1)
Acta Mathematica Sinica, English Series     Hybrid Journal   (Followers: 6, SJR: 0.379, CiteScore: 1)
Acta Mathematica Vietnamica     Hybrid Journal   (SJR: 0.27, CiteScore: 0)
Acta Mathematicae Applicatae Sinica, English Series     Hybrid Journal   (SJR: 0.208, CiteScore: 0)
Acta Mechanica     Hybrid Journal   (Followers: 25, SJR: 1.04, CiteScore: 2)
Acta Mechanica Sinica     Hybrid Journal   (Followers: 5, SJR: 0.607, CiteScore: 2)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 7, SJR: 0.576, CiteScore: 2)
Acta Meteorologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.638, CiteScore: 1)
Acta Neurochirurgica     Hybrid Journal   (Followers: 7, SJR: 0.822, CiteScore: 2)
Acta Neurologica Belgica     Hybrid Journal   (Followers: 2, SJR: 0.376, CiteScore: 1)
Acta Neuropathologica     Hybrid Journal   (Followers: 4, SJR: 7.589, CiteScore: 12)
Acta Oceanologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.334, CiteScore: 1)
Acta Physiologiae Plantarum     Hybrid Journal   (Followers: 4, SJR: 0.574, CiteScore: 2)
Acta Politica     Hybrid Journal   (Followers: 19, SJR: 0.605, CiteScore: 1)
Activitas Nervosa Superior     Hybrid Journal   (SJR: 0.147, CiteScore: 0)
Adaptive Human Behavior and Physiology     Hybrid Journal  
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 8, SJR: 0.103, CiteScore: 0)
ADHD Attention Deficit and Hyperactivity Disorders     Hybrid Journal   (Followers: 28, SJR: 0.72, CiteScore: 2)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 9)
Administration and Policy in Mental Health and Mental Health Services Research     Partially Free   (Followers: 19, SJR: 1.005, CiteScore: 2)
Adolescent Research Review     Hybrid Journal  
Adsorption     Hybrid Journal   (Followers: 5, SJR: 0.703, CiteScore: 2)
Advanced Composites and Hybrid Materials     Hybrid Journal  
Advanced Fiber Materials     Full-text available via subscription  
Advances in Applied Clifford Algebras     Hybrid Journal   (Followers: 4, SJR: 0.698, CiteScore: 1)
Advances in Astronautics Science and Technology     Hybrid Journal  
Advances in Atmospheric Sciences     Hybrid Journal   (Followers: 40, SJR: 0.956, CiteScore: 2)
Advances in Computational Mathematics     Hybrid Journal   (Followers: 21, SJR: 0.812, CiteScore: 1)
Advances in Contraception     Hybrid Journal   (Followers: 3)
Advances in Data Analysis and Classification     Hybrid Journal   (Followers: 58, SJR: 1.09, CiteScore: 1)
Advances in Gerontology     Partially Free   (Followers: 8, SJR: 0.144, CiteScore: 0)
Advances in Health Sciences Education     Hybrid Journal   (Followers: 35, SJR: 1.64, CiteScore: 2)
Advances in Manufacturing     Hybrid Journal   (Followers: 3, SJR: 0.475, CiteScore: 2)
Advances in Neurodevelopmental Disorders     Hybrid Journal  
Advances in Polymer Science     Hybrid Journal   (Followers: 49, SJR: 1.04, CiteScore: 3)
Advances in Therapy     Hybrid Journal   (Followers: 5, SJR: 1.075, CiteScore: 3)
Aegean Review of the Law of the Sea and Maritime Law     Hybrid Journal   (Followers: 7)
Aequationes Mathematicae     Hybrid Journal   (Followers: 2, SJR: 0.517, CiteScore: 1)
Aerobiologia     Hybrid Journal   (Followers: 3, SJR: 0.673, CiteScore: 2)
Aerosol Science and Engineering     Hybrid Journal  
Aerospace Systems     Hybrid Journal  
Aerotecnica Missili & Spazio : J. of Aerospace Science, Technologies & Systems     Hybrid Journal  
Aesthetic Plastic Surgery     Hybrid Journal   (Followers: 11, SJR: 0.825, CiteScore: 1)
African Archaeological Review     Hybrid Journal   (Followers: 21, SJR: 0.862, CiteScore: 1)
Afrika Matematika     Hybrid Journal   (Followers: 1, SJR: 0.235, CiteScore: 0)
Ageing Intl.     Hybrid Journal   (Followers: 7, SJR: 0.39, CiteScore: 1)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
Aging Clinical and Experimental Research     Hybrid Journal   (Followers: 3, SJR: 0.67, CiteScore: 2)
Agricultural Research     Hybrid Journal   (Followers: 6, SJR: 0.276, CiteScore: 1)
Agriculture and Human Values     Open Access   (Followers: 15, SJR: 1.173, CiteScore: 3)
Agroforestry Systems     Open Access   (Followers: 20, SJR: 0.663, CiteScore: 1)
Agronomy for Sustainable Development     Open Access   (Followers: 15, SJR: 1.864, CiteScore: 6)
AI & Society     Hybrid Journal   (Followers: 9, SJR: 0.227, CiteScore: 1)
AIDS and Behavior     Hybrid Journal   (Followers: 16, SJR: 1.792, CiteScore: 3)
Air Quality, Atmosphere & Health     Hybrid Journal   (Followers: 4, SJR: 0.862, CiteScore: 3)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Algebra and Logic     Hybrid Journal   (Followers: 7, SJR: 0.531, CiteScore: 0)
Algebra Universalis     Hybrid Journal   (Followers: 2, SJR: 0.583, CiteScore: 1)
Algebras and Representation Theory     Hybrid Journal   (Followers: 1, SJR: 1.095, CiteScore: 1)
Algorithmica     Hybrid Journal   (Followers: 9, SJR: 0.56, CiteScore: 1)
Allergo J.     Full-text available via subscription   (Followers: 1, SJR: 0.234, CiteScore: 0)
Allergo J. Intl.     Hybrid Journal   (Followers: 2)
Alpine Botany     Hybrid Journal   (Followers: 5, SJR: 1.11, CiteScore: 3)
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 2)
AMBIO     Hybrid Journal   (Followers: 10, SJR: 1.569, CiteScore: 4)
American J. of Cardiovascular Drugs     Hybrid Journal   (Followers: 17, SJR: 0.951, CiteScore: 3)
American J. of Community Psychology     Hybrid Journal   (Followers: 29, SJR: 1.329, CiteScore: 2)
American J. of Criminal Justice     Hybrid Journal   (Followers: 9, SJR: 0.772, CiteScore: 1)
American J. of Cultural Sociology     Hybrid Journal   (Followers: 18, SJR: 0.46, CiteScore: 1)
American J. of Dance Therapy     Hybrid Journal   (Followers: 6, SJR: 0.181, CiteScore: 0)
American J. of Potato Research     Hybrid Journal   (Followers: 3, SJR: 0.611, CiteScore: 1)
American J. of Psychoanalysis     Hybrid Journal   (Followers: 22, SJR: 0.314, CiteScore: 0)
American Sociologist     Hybrid Journal   (Followers: 16, SJR: 0.35, CiteScore: 0)
Amino Acids     Hybrid Journal   (Followers: 7, SJR: 1.135, CiteScore: 3)
AMS Review     Partially Free   (Followers: 4)
Analog Integrated Circuits and Signal Processing     Hybrid Journal   (Followers: 10, SJR: 0.211, CiteScore: 1)
Analysis and Mathematical Physics     Hybrid Journal   (Followers: 6, SJR: 0.536, CiteScore: 1)
Analysis in Theory and Applications     Hybrid Journal   (Followers: 1)
Analysis of Verbal Behavior     Hybrid Journal   (Followers: 6)
Analytical and Bioanalytical Chemistry     Hybrid Journal   (Followers: 32, SJR: 0.978, CiteScore: 3)
Anatomical Science Intl.     Hybrid Journal   (Followers: 3, SJR: 0.367, CiteScore: 1)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3, SJR: 2.177, CiteScore: 5)
Animal Cognition     Hybrid Journal   (Followers: 23, SJR: 1.389, CiteScore: 3)
Annales françaises de médecine d'urgence     Hybrid Journal   (Followers: 1, SJR: 0.192, CiteScore: 0)
Annales Henri Poincaré     Hybrid Journal   (Followers: 3, SJR: 1.097, CiteScore: 2)
Annales mathématiques du Québec     Hybrid Journal   (Followers: 4, SJR: 0.438, CiteScore: 0)
Annali dell'Universita di Ferrara     Hybrid Journal   (SJR: 0.429, CiteScore: 0)
Annali di Matematica Pura ed Applicata     Hybrid Journal   (Followers: 1, SJR: 1.197, CiteScore: 1)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 19, SJR: 1.042, CiteScore: 3)
Annals of Combinatorics     Hybrid Journal   (Followers: 4, SJR: 0.932, CiteScore: 1)
Annals of Data Science     Hybrid Journal   (Followers: 13)
Annals of Dyslexia     Hybrid Journal   (Followers: 10, SJR: 0.85, CiteScore: 2)
Annals of Finance     Hybrid Journal   (Followers: 35, SJR: 0.579, CiteScore: 1)
Annals of Forest Science     Hybrid Journal   (Followers: 7, SJR: 0.986, CiteScore: 2)
Annals of Global Analysis and Geometry     Hybrid Journal   (Followers: 1, SJR: 1.228, CiteScore: 1)
Annals of Hematology     Hybrid Journal   (Followers: 15, SJR: 1.043, CiteScore: 2)
Annals of Mathematics and Artificial Intelligence     Hybrid Journal   (Followers: 12, SJR: 0.413, CiteScore: 1)
Annals of Microbiology     Hybrid Journal   (Followers: 11, SJR: 0.479, CiteScore: 2)
Annals of Nuclear Medicine     Hybrid Journal   (Followers: 5, SJR: 0.687, CiteScore: 2)
Annals of Operations Research     Hybrid Journal   (Followers: 11, SJR: 0.943, CiteScore: 2)
Annals of Ophthalmology     Hybrid Journal   (Followers: 13)
Annals of PDE     Hybrid Journal  
Annals of Regional Science     Hybrid Journal   (Followers: 9, SJR: 0.614, CiteScore: 1)
Annals of Software Engineering     Hybrid Journal   (Followers: 13)
Annals of Solid and Structural Mechanics     Hybrid Journal   (Followers: 11, SJR: 0.239, CiteScore: 1)
Annals of Surgical Oncology     Hybrid Journal   (Followers: 15, SJR: 1.986, CiteScore: 4)
Annals of Telecommunications     Hybrid Journal   (Followers: 9, SJR: 0.223, CiteScore: 1)
Annals of the Institute of Statistical Mathematics     Hybrid Journal   (Followers: 1, SJR: 1.495, CiteScore: 1)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 5, SJR: 0.834, CiteScore: 2)
Apidologie     Hybrid Journal   (Followers: 4, SJR: 1.22, CiteScore: 3)
APOPTOSIS     Hybrid Journal   (Followers: 9, SJR: 1.424, CiteScore: 4)
Applicable Algebra in Engineering, Communication and Computing     Hybrid Journal   (Followers: 2, SJR: 0.294, CiteScore: 1)
Applications of Mathematics     Hybrid Journal   (Followers: 3, SJR: 0.602, CiteScore: 1)
Applied Biochemistry and Biotechnology     Hybrid Journal   (Followers: 44, SJR: 0.571, CiteScore: 2)
Applied Biochemistry and Microbiology     Hybrid Journal   (Followers: 18, SJR: 0.21, CiteScore: 1)
Applied Categorical Structures     Hybrid Journal   (Followers: 4, SJR: 0.49, CiteScore: 0)
Applied Composite Materials     Hybrid Journal   (Followers: 53, SJR: 0.58, CiteScore: 2)
Applied Entomology and Zoology     Partially Free   (Followers: 7, SJR: 0.422, CiteScore: 1)
Applied Geomatics     Hybrid Journal   (Followers: 3, SJR: 0.733, CiteScore: 3)
Applied Geophysics     Hybrid Journal   (Followers: 9, SJR: 0.488, CiteScore: 1)
Applied Intelligence     Hybrid Journal   (Followers: 15, SJR: 0.6, CiteScore: 2)
Applied Magnetic Resonance     Hybrid Journal   (Followers: 4, SJR: 0.319, CiteScore: 1)
Applied Mathematics & Optimization     Hybrid Journal   (Followers: 10, SJR: 0.886, CiteScore: 1)
Applied Mathematics - A J. of Chinese Universities     Hybrid Journal   (Followers: 1, SJR: 0.17, CiteScore: 0)
Applied Mathematics and Mechanics     Hybrid Journal   (Followers: 5, SJR: 0.461, CiteScore: 1)
Applied Microbiology and Biotechnology     Hybrid Journal   (Followers: 67, SJR: 1.182, CiteScore: 4)
Applied Physics A     Hybrid Journal   (Followers: 10, SJR: 0.481, CiteScore: 2)
Applied Physics B: Lasers and Optics     Hybrid Journal   (Followers: 26, SJR: 0.74, CiteScore: 2)
Applied Psychophysiology and Biofeedback     Hybrid Journal   (Followers: 8, SJR: 0.519, CiteScore: 2)
Applied Research in Quality of Life     Hybrid Journal   (Followers: 12, SJR: 0.316, CiteScore: 1)
Applied Solar Energy     Hybrid Journal   (Followers: 22, SJR: 0.225, CiteScore: 0)
Applied Spatial Analysis and Policy     Hybrid Journal   (Followers: 6, SJR: 0.542, CiteScore: 1)
Aquaculture Intl.     Hybrid Journal   (Followers: 26, SJR: 0.591, CiteScore: 2)
Aquarium Sciences and Conservation     Hybrid Journal   (Followers: 2)
Aquatic Ecology     Hybrid Journal   (Followers: 37, SJR: 0.656, CiteScore: 2)
Aquatic Geochemistry     Hybrid Journal   (Followers: 3, SJR: 0.591, CiteScore: 1)
Aquatic Sciences     Hybrid Journal   (Followers: 14, SJR: 1.109, CiteScore: 3)
Arabian J. for Science and Engineering     Hybrid Journal   (Followers: 5, SJR: 0.303, CiteScore: 1)
Arabian J. of Geosciences     Hybrid Journal   (Followers: 2, SJR: 0.319, CiteScore: 1)
Archaeological and Anthropological Sciences     Hybrid Journal   (Followers: 22, SJR: 1.052, CiteScore: 2)
Archaeologies     Hybrid Journal   (Followers: 12, SJR: 0.224, CiteScore: 0)
Archiv der Mathematik     Hybrid Journal   (Followers: 1, SJR: 0.725, CiteScore: 1)
Archival Science     Hybrid Journal   (Followers: 68, SJR: 0.745, CiteScore: 2)
Archive for History of Exact Sciences     Hybrid Journal   (Followers: 7, SJR: 0.186, CiteScore: 1)
Archive for Mathematical Logic     Hybrid Journal   (Followers: 3, SJR: 0.909, CiteScore: 1)
Archive for Rational Mechanics and Analysis     Hybrid Journal   (SJR: 3.93, CiteScore: 3)
Archive of Applied Mechanics     Hybrid Journal   (Followers: 6, SJR: 0.79, CiteScore: 2)
Archives and Museum Informatics     Hybrid Journal   (Followers: 168, SJR: 0.101, CiteScore: 0)
Archives of Computational Methods in Engineering     Hybrid Journal   (Followers: 6, SJR: 1.41, CiteScore: 5)
Archives of Dermatological Research     Hybrid Journal   (Followers: 7, SJR: 1.006, CiteScore: 2)
Archives of Environmental Contamination and Toxicology     Hybrid Journal   (Followers: 14, SJR: 0.773, CiteScore: 2)
Archives of Gynecology and Obstetrics     Hybrid Journal   (Followers: 18, SJR: 0.956, CiteScore: 2)
Archives of Microbiology     Hybrid Journal   (Followers: 9, SJR: 0.644, CiteScore: 2)
Archives of Orthopaedic and Trauma Surgery     Hybrid Journal   (Followers: 9, SJR: 1.146, CiteScore: 2)
Archives of Osteoporosis     Hybrid Journal   (Followers: 2, SJR: 0.71, CiteScore: 2)
Archives of Sexual Behavior     Hybrid Journal   (Followers: 11, SJR: 1.493, CiteScore: 3)
Archives of Toxicology     Hybrid Journal   (Followers: 18, SJR: 1.541, CiteScore: 5)
Archives of Virology     Hybrid Journal   (Followers: 5, SJR: 0.973, CiteScore: 2)
Archives of Women's Mental Health     Hybrid Journal   (Followers: 17, SJR: 1.274, CiteScore: 3)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2, SJR: 0.946, CiteScore: 3)
ArgoSpine News & J.     Hybrid Journal  
Argumentation     Hybrid Journal   (Followers: 6, SJR: 0.349, CiteScore: 1)
Arid Ecosystems     Hybrid Journal   (Followers: 3, SJR: 0.2, CiteScore: 0)
Arkiv för Matematik     Hybrid Journal   (Followers: 1, SJR: 0.766, CiteScore: 1)
arktos : The J. of Arctic Geosciences     Hybrid Journal  
Arnold Mathematical J.     Hybrid Journal   (Followers: 1, SJR: 0.355, CiteScore: 0)
Arthropod-Plant Interactions     Hybrid Journal   (Followers: 2, SJR: 0.839, CiteScore: 2)
Arthroskopie     Hybrid Journal   (Followers: 1, SJR: 0.131, CiteScore: 0)
Artificial Intelligence and Law     Hybrid Journal   (Followers: 12, SJR: 0.937, CiteScore: 2)
Artificial Intelligence Review     Hybrid Journal   (Followers: 21, SJR: 0.833, CiteScore: 4)
Artificial Life and Robotics     Hybrid Journal   (Followers: 10, SJR: 0.226, CiteScore: 0)
Asia Europe J.     Hybrid Journal   (Followers: 4, SJR: 0.504, CiteScore: 1)
Asia Pacific Education Review     Hybrid Journal   (Followers: 12, SJR: 0.479, CiteScore: 1)
Asia Pacific J. of Management     Hybrid Journal   (Followers: 17, SJR: 1.185, CiteScore: 2)

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Similar Journals
Journal Cover
Advances in Gerontology
Journal Prestige (SJR): 0.144
Number of Followers: 8  
  Partially Free Journal Partially Free Journal
ISSN (Print) 2079-0570 - ISSN (Online) 2079-0589
Published by Springer-Verlag Homepage  [2574 journals]
  • Age-Related Structural Changes in Primary Visual Cortex Cells of Rats
           under High-Intensity Light Exposure
    • Abstract: An experiment using 20 white male Wistar rats has shown that exposure to 3500 lux of light for 7 days causes morphological changes in the II, IV, and V layers of the primary visual cortex. This was seen in an increased percentage of reversibly and irreversibly altered neurons, mainly in the fourth layer of 18-month-old rats (p ≤ 0.05). In response to light exposure, the percentage of hyperchromic wrinkled neurons in 18‑month-old rats rises to 6% (5; 8.5), the percentage of neurons with total chromatolysis rises to 10% (8.5; 14) compared to a 1% (0.5; 14) and 6% (5; 8) rise in 3-month-old rats respectively (p ≤ 0.05). The neural damage leads to a glial reaction reflected in an increased percentage of glia with signs of edema and swelling, hyperchromia without the nucleus and cytoplasm shrinkage (p ≤ 0.05), neuronophagia, and also the intrusion of the glia cells into the neuron cytoplasm for the initiation of intracellular reparation. The destructive changes are characterized by the gliacyte hyperchromia with the shrinkage of the nucleus and cytoplasm. The percentage of these gliacytes increases significantly in 18-month-old rats under the light exposure compared to the indices in young animals (p ≤ 0.05).
      PubDate: 2018-10-01
  • Age-Related Dynamics of the Content of Matrix Metalloproteinases (MMP-1,
           -2, -3, and -9) and Tissue Inhibitors of Matrix Metalloproteinases
           (TIMP-1, -2, and -4) in Blood Plasma of Residents of the European Part of
           Russia’s Arctic Zone
    • Abstract: This work presents the results of the first ever study of the enzymes involved in the regulation of extracellular matrix metabolism in the European part of Russia’s Arctic zone. The content of matrix metalloproteinases (MMP-1, -2, -3, and -9) and tissue inhibitors of matrix metalloproteinases (TIMP-1, -2, and -4) in blood plasma was evaluated in 91 men, residents of the European part of the Russian Arctic (67° N) and 14 men, residents of Western Siberia (55° N). The content of MMP-1 and MMP-9, as well as TIMP-1 and TIMP-4 in the blood plasma was higher in northerners relative to the Western Siberia residents. The age-related dynamics of MMPs and TIMPs in northerners had a multidirectional trend. We observed the maximum content of MMP-1 and MMP-9 in the group of 30–39 year olds; MMP-3, in the group of 40–49 year olds. The content of these enzymes tended to decrease with age. We found the maximum content of TIMP-1 and TIMP-2 in the group of 50–59 year olds; TIMP-4, in the group of 60–69 year olds; whereas we observed the minimum content of these enzymes in the group of young men under 29 years old. The hyaluronidase activity in plasma was minimal in the group of 30–39 year olds; it increased with age, reaching a maximum value in the group of 50–59 year olds. We can assume that the age-related imbalance in the MMP/TIMP system (a decrease in MMP content with age and vice versa, an increase in TIMP content in older age groups) is one of the reasons for the age-related increase in interstitial fibrosis and premature aging of northerners.
      PubDate: 2018-10-01
  • Correlations of the Parameters of Carbohydrate Metabolism and Saturated
           Fatty Acids in the Blood Serum of Elderly People
    • Abstract: The study involves 106 elderly subjects (61–74 years old) living in the Arctic; 42 of them are residents of the Subarctic region (SR) and 64, of the Arctic region (AR). The contents of saturated fatty acids (SFAs) comprising short chain (SCFA), medium chain (MCFA), and long chain (LCFA) fatty acids, are determined by gas liquid chromatography of the blood serum. The parameters of the carbohydrate metabolism are assessed by spectrophotometry. Correlation analysis demonstrates the absence of statistically significant correlations of glucose, lactate, and pyruvate levels with the contents of SCFAs, MCFAs, and LCFAs (r = 0.2–0.29, p = 0.08–0.786) among the examined elderly SR residents compared with the AR residents, who show lower rates of excess glucose and lactate and lower rates of deficient pyruvate. On the background of higher excess glucose and deficiency rates, the examined AR cohort shows the strongest correlations with LCFAs (hexadecanoic, heptadecanoic, octadecanoic, behenic, and tricosanoic acids), somewhat more moderate correlations with MCFAs (tetradecanoic and pentadecanoic acids) and SCFAs (pelargonic acid), correlations of pyruvate deficiency with MCFAs (dodecanoic and tetradecanoic acids and total MCFA content) and SCFAs (decanoic acid), and correlations of an insignificant decrease in the rate of excess lactate and lactate/pyruvate with LCFAs (hexadecanoic, heptadecanoic, octadecanoic, and tricosanoic acids), MCFAs (dodecanoic and tridecanoic acids), and SCFAs (hexanoic and caprylic acids).
      PubDate: 2018-10-01
  • Regression of Survivability Variance on the Cohort Age in Drosophila
           melanogaster. I. Survivability: Reaction Norm and Its Inheritance
    • Abstract: A standard analysis of survivability implies counting the share of living individuals in a cohort at a certain moment in time. We analyze in this work the regression of survivability variance on cohort age in several generations of Drosophila melanogaster Canton-S stock. This estimation reflects the reaction norm for survivability. The approach reveals at least three age phases. The first and second can be approximated by an exponential equation and the third by a logistic dose-response curve. Parameters of these equations remain stable for tens of generations and must therefore be highly heritable.
      PubDate: 2018-10-01
  • Young and Old Animals Use Different Strategies for Forming an Immune
           Response to Infectious Agents ( Pseudomonas aeruginosa and Escherichia
           coli )
    • Abstract: This paper presents the results of a study of the features of the immune response to the injection of bacterial suspension (Pseudomonas aeruginosa and Escherichia coli) in young (3 months) and old (20 months) Wistar rats at 3, 5, and 7 days after infection. We assessed the contents of circulating immune complexes (CICs) and complement components C3 in dynamics and the activity of oxygen-dependent and oxygen-independent phagocytosis. Bacterial infection was accompanied by a multiple increase in the content of circulating immune complexes in young and, especially, in old animals. It remained at a high level from the third to the seventh day of the pathology development in young animals, while their content decreased to the seventh day in old animals. In the presence of infectious process, the content of complement components C3 decreased in young animals, and it increased in old animals, in the case of infection with P. aeruginosa and E. coli. The activity of oxygen-dependent and oxygen-independent phagocytosis decreased in different ways in young and old infected animals, i.e., the ratio of the forms of phagocytosis in old and young animals was different. Old animals were not inferior to the young ones in terms of the ability of the immune system to respond to the presence of an infectious agent. They used a different strategy for eliciting the immune response.
      PubDate: 2018-10-01
  • The Use of Natural Platelet Autoplasma and Its Thermally Processed
           Modifications for Correction of Age-Related Changes of Skin
    • Abstract: This paper presents the results of a comparative prospective study of correcting age-related changes in facial and neck skin of 72 patients using native platelet auto plasma, as well as a new method for obtaining thermally processed modifications of it via denaturation of protein plasma fractions when heated in a thermostat to different temperatures (Patent No. 2629527/August 29, 2017). The results obtained suggest that the use of a combination of native platelet auto plasma (PAP) with its thermally processed modifications to correct age-related changes in the skin of the face and neck is more effective than monotherapy of native PAP. The absence of complications during the observation period and the autologous nature of the material means that this treatment method has a high level of safety.
      PubDate: 2018-10-01
  • The Elemental Status of Senior Residents in Petrozavodsk
    • Abstract: The goal of our study was to investigate the elemental status in Petrozavodsk residents from senior age groups compared to analogous values recorded in the residents of Russia’s central regions. We based our investigations on hair analysis, using the techniques of atomic emission spectrometry and inductively coupled argon plasma mass spectrometry. Our investigations have shown no deviations in the Al, As, Be, and Ni contents in hair. We found insignificant deviations in the Cd, Li, Sn, and V contents. We recorded deviations towards higher values in the hair concentrations of toxic Hg and Pb and in the conditionally essential microelement B. We found deviations towards lower values in the hair concentrations of Co, Ca, Zn, Mg, I, Fe, P, Cu, Mn, Cr, Se, and Si. The indicated deviations in the elemental contents could be caused by both the age-specific factors and the natural, ecological, and social living conditions of the population of Russia’s European North. The established elemental imbalance creates risks for developing endemic microelementoses and worsens long-term health prospects for Petrozavodsk’s senior population.
      PubDate: 2018-10-01
  • Histometric Symptoms of Age-Sensitive Changes of Bone Tissue
    • Abstract: This study presents the results of complex histomorphometric research of the features of age-related dynamics of bone tissue. We used as study material samples of the distal epiphysis and diaphysis of the left tibia from 348 male corpses aging from 0 to 90 years. The group of microosteometric features that have the strongest correlation with age is established in different age groups; their quantitative characteristics are given here. It has been clarified that the trends of age-related changes in the structural components of bone tissue correspond to the basic patterns of growth, remodeling, and depend on the species and their localization. Conceptual positions of age involution of bone tissue are proposed in this study.
      PubDate: 2018-10-01
  • Predictors of One-Year Outcomes after Percutaneous Coronary Interventions
           in Octogenarian Patients with Acute Coronary Syndrome
    • Abstract: This work investigates the long-term outcomes of coronary stenting and predictors of two-year outcomes in octogenarian patients with acute coronary syndrome. A total of 406 patients with STEMI, NSTEMI and unstable angina undergoing percutaneous coronary intervention (PCI) were included in the study. We assessed the results at a median follow up of 20 months, from 1 year to 3 years. In-hospital mortality in the group of patients older than 80 was 8% and the long-term mortality was 21%. Cardiogenic shock, multi-vessel coronary disease, ejection fraction less than 35, and left main coronary artery lesion were independent predictors of long-term mortality. The best prognosis corresponded to those of drug eluting stents use, radial approach and GP IIb/IIIa use in patients with ST-segment elevation myocardial infarction. The progression of cardiac and renal failure was the main cause of death during this period. Our results suggested that percutaneous coronary interventions in octogenarian patients with acute coronary syndrome were associated with good clinical and long-term outcomes. DES use, radial approach and GP IIb/IIIa use in patients with ST-segment elevation myocardial infarction were associated with improved all-cause mortality in our population.
      PubDate: 2018-10-01
  • Lipofuscin and Mitolipofuscin in the Organs of Young and Adult Rats
    • Abstract: The levels of lipofuscin (aging pigment) were compared in four organs (liver, kidney, heart, brain) of young and adult rats, as well as in the suspension of hepatic mitochondria. Mitochondrial lipofuscin—mitolipofuscin fluorescing in the blue region—was seen to make the major contribution to hepatic lipofuscin. It is clear that mitolipofuscin also makes a significant contribution in other organs. The age-related accumulation of lipofuscin was shown to occur in all rat organs, but in the brain least of all. In addition to fluorescent lipofuscin, non-fluorescent protein aggregates were found in all organs, mostly in the heart. A considerable portion is covalently cross-linked aggregates not destroyed by detergents. Their number also increases with age.
      PubDate: 2018-10-01
  • Study of Age-Related Changes in Compensatory Processes in the Model of
           Neurodegeneration of the Nigrostriatal System in Rats
    • Abstract: It is generally accepted that old age is the main risk factor for the development and progression of Parkinson’s disease (PD). However, there is currently no data available that experimentally confirm the age dependence of the neurodegeneration progression rate and the activity of compensatory processes in the nigrostriatal system in the development of PD. The present study applies a model of nigrostriatal system neurodegeneration in rats of different ages, which was developed using the microinjections with proteasome inhibitor lactacystin (LC) into the substantia nigra pars compacta (SNpc). The model reproduces the main pathomorphological signs of PD with great reliability. It has been demonstrated that the administration of LC to old rats, compared to young and middle-aged ones, causes more pronounced neurodegenerative changes in the nigrostriatal system which are associated with impairments in fine motor function, a decrease in the growth of the stress-inducible heat shock protein Hsp70 in surviving neurons of SNpc, and a decrease in contents of tyrosine hydroxylase and the vesicular monoamine transporter 2. The data obtained suggest that the aging-related decrease in Hsp70 expression together with a decrease in the efficiency of compensatory processes is a significant factor which determines the progression of pathology in the nigrostriatal system in PD model in old rats. The age-related loss of compensatory mechanisms observed may be one of the causes of the rapid PD progression in the elderly.
      PubDate: 2018-10-01
  • Circadian Rhythms of Antioxidant Enzyme’s Activity in Young and Adult
           Rats under Light Deprivation Conditions
    • Abstract: We have studied the age-related features of circadian rhythms of superoxide dismutase (SOD) and catalase activity in the liver of rats under conditions of light deprivation. In standard light conditions (LD), significant daily fluctuations in SOD activity with a maximum at 7:00 a.m. were detected only in young animals (1.5 months) while catalase activity was observed in both young animals (1.5 months) and adults (7.5 months) with peak at 4:00 a.m. The daily dynamics of total and specific activity of SOD and catalase in the liver of young and adult rats differed, depending on the period of ontogeny in which the impact of light deprivation had begun. When females after giving birth and their offspring were moved to darkness (group LD/DD), the circadian rhythms of SOD and catalase activities were found in the young rats and were absent in adult rats. However, circadian rhythms of the antioxidant enzymes (AOE) activities were inherent only in adult rats when light deprivation impacted on pregnant females (group DD/DD). Changes in circadian rhythms under light deprivation were characterized either by a phase shift of the enzymes activity (in LD/DD group) or by a violation of their development in ontogeny (in DD/DD group). With aging a significant decrease of catalase activity was compensated by an increase in the amplitude of circadian rhythms of this enzyme activity in animals of all groups. The presence of an ultradian rhythm in the general circadian cycle characterized by a second peak with a smaller amplitude and shorter period can be considered a distinctive feature of daily fluctuations in AOЕ activity in young rats in LD and LD/DD groups.
      PubDate: 2018-10-01
  • Contribution of Senior Age Groups to Changes in Life Expectancy Indicators
           for Russia’s Megalopolises (Moscow and St. Petersburg)
    • Abstract: This study analyzes the dynamics of life expectancy at birth (LE0) and at older ages and the contribution of older ages (60+) to changes in life expectancy in Russian megacities Moscow and St. Petersburg. We studied the contributions of aggregated age groups to differences between LE0 values for Moscow and St. Petersburg. Our study has shown that the increase in life expectancy at senior ages makes a significant contribution to the increase of the LE0 index.
      PubDate: 2018-10-01
  • The Effect of Cryopreserved Cord Blood Nucleated Cells on Pathological
           Processes in the Progressive Aging of the Brain (Experimental Study)
    • Abstract: This work presents data on morphometric indices of the vascular bed and brain substance of spontaneously hypertensive SHR rats, which may be considered evidence of the developing pathological brain aging processes in these animals. Chronic alcohol intoxication aggravates the neurodegeneration, significantly reducing the indices of the neuroglial index, the number of functioning vessels and activating the LPO processes. A single intraperitoneal administration of cryopreserved human cord blood nucleated cells in a dose of (1–5) × 107/kg promoted the regeneration of neurocells, the stimulation of angiogenesis and an increased level and quality of neurotissue metabolism, reducing the signs of dystrophic, destructive and pathologically altered compensatory adaptive processes in the rat’s brain as a result of the restoration of its microhemocirculation and cytoarchitecture.
      PubDate: 2018-10-01
  • Possible Approaches to Increase the Longevity of Experimental Animals
    • Abstract: A statistically significant difference in the cumulative survival of Wistar rats born in different seasons has been shown: animals born in late November–early December had an average lifespan 24.8% longer, a minimum lifespan 14.3% longer, and a maximum lifespan 20.7% longer in comparison with animals born in April. Transplantation of thymus tissue into the immune privileged anterior chamber of the eye in animals born both in November and April has shown a geroprotective effect.
      PubDate: 2018-10-01
  • Russia Needs the Development of Geriatrics: On the Paper by V.S.
           Myakоtnykh “Age-Associated Pathology and the Place of Geriatrics as a
           Medical Specialty (Reflections of a Clinician)”
    • PubDate: 2018-07-01
  • Comments on the Paper by V.S. Myakotnykh “Age-Associated Pathology and
           the Place of Geriatrics as a Medical Specialty (Reflections of a
    • PubDate: 2018-07-01
  • Influence of Bone Marrow Autotransplantation on the Neurotransmitter
           Structures of appendix vermiformis in Old Rats
    • Abstract: The influence of bone marrow autotransplantation on neurotransmitter structures of appendix vermiformis was studied. The investigation revealed that an increase in the number of neurotransmitter structures (mast and granular luminescent cells) with a high content of catecholamines and serotonin was noted in old rats 40 min after bone marrow autotransplantation. Cellular differentiations with a high neuroamine content were found in the reproductive center of appendix vermiformis lymphoid-nodes. Two hours after bone marrow autotransplantation, their number decreased and the content of catecholamines and serotonin decreased as well. The immunohistochemical reaction showed an increase in cellular proliferative activity, both in proper t. mucosa plate crypts and appendix vermiformis lymphoid nodules, up to 40 min of the experiment. After 2 h, Ki-67 positive cells decreased both in t. mucosa and t. s/mucosa of appendix vermiformis.
      PubDate: 2018-07-01
  • Molecular Aspects of the Geroprotective Effect of Peptide KE in Human Skin
    • Abstract: Skin aging is an current problem of modern geriatric cosmetology. One promising method to decelerate the process of age-related skin changes is the use of cosmetics with short peptides. The goal of the work was to study the effect of peptide KE (Lys-Glu, Vilon) on the expression of aging markers of human fibroblasts in an in vitro model. The expression of collagen type 1 and sirtuin 6 was studied with immunofluorescent confocal microscopy in “young” and “old” cultures of skin fibroblasts. It has been found that the area of expression of collagen type 1 and sirtuin 6 decreases by 3.5 and 3.6 times, respectively, in skin fibroblast cultures with aging. Peptide KE increases the expression area of collagen type 1 in old skin fibroblast cultures by 83%; the expression area of sirtuin 6 in young and old cultures of skin fibroblasts increased by 1.6 and 2.6 times, respectively. Thus, peptide KE increases the functional activity of skin fibroblasts and decelerates their senescence.
      PubDate: 2018-07-01
  • Thyroid Hormone Receptors in Human Skin during Aging
    • Abstract: Published data suggest that thyroid hormones play a role in the regulation of dermal fibroblasts during aging. This goal of this work was to study the levels of thyroid hormone receptors in human dermal fibroblasts, from embryonic development to extreme old age. Skin specimens from human fetuses that died antenatally from 20 to 40 weeks of pregnancy and humans who died from different causes from birth to age 85 years were used for the study. The total number of fibroblasts, the percentage of dermal fibroblasts positive for proliferating cell nuclear antigen (PCNA), and the expression of thyroid hormone receptors α and β in dermal fibroblasts were examined. PCNA and thyroid hormone receptors were viewed immunohistochemically. The total fibroblast number in the dermis was counted in sections stained with hematoxylin and eosin. The results showed that the maximal levels of thyroid hormone receptors α and β were observed from the 20th to 40th weeks of pregnancy. The levels of thyroid hormone receptors α and β were decreased from birth to age 40 years. From 41 to 85 years, the levels of thyroid hormone receptors were approximately the same. The total number and percentage of PCNA-positive fibroblasts in the dermis were decreased with progression of age. The most significant age-dependent reduction in the total and PCNA-positive number of dermal fibroblasts was observed from the antenatal period to the age of 40. Correlation analysis and one-way ANOVA showed that age-dependent decrease in the number of fibroblasts and the retardation of their proliferation in the human dermis is significantly associated with an age-related decrease in the level of thyroid hormone receptors α and β in dermal fibroblasts. The results suggest that thyroid hormone receptors are involved in an age-dependent decrease in the number and proliferation of fibroblasts in human dermis.
      PubDate: 2018-07-01
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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