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Publisher: Springer-Verlag   (Total: 2335 journals)

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Showing 1 - 200 of 2335 Journals sorted alphabetically
3D Research     Hybrid Journal   (Followers: 19, SJR: 0.214, h-index: 10)
4OR: A Quarterly J. of Operations Research     Hybrid Journal   (Followers: 9, SJR: 1.073, h-index: 25)
AAPS J.     Hybrid Journal   (Followers: 16, SJR: 1.192, h-index: 74)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6, SJR: 0.718, h-index: 54)
Abdominal Imaging     Hybrid Journal   (Followers: 16, SJR: 0.723, h-index: 60)
Abhandlungen aus dem Mathematischen Seminar der Universitat Hamburg     Hybrid Journal   (Followers: 2, SJR: 0.447, h-index: 12)
Academic Psychiatry     Full-text available via subscription   (Followers: 22, SJR: 0.492, h-index: 32)
Academic Questions     Hybrid Journal   (Followers: 7, SJR: 0.135, h-index: 6)
Accreditation and Quality Assurance: J. for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 25, SJR: 0.378, h-index: 30)
Acoustical Physics     Hybrid Journal   (Followers: 10, SJR: 0.355, h-index: 20)
Acta Analytica     Hybrid Journal   (Followers: 7, SJR: 0.387, h-index: 6)
Acta Applicandae Mathematicae     Hybrid Journal   (Followers: 1, SJR: 0.624, h-index: 34)
Acta Biotheoretica     Hybrid Journal   (Followers: 5, SJR: 0.419, h-index: 25)
Acta Diabetologica     Hybrid Journal   (Followers: 14, SJR: 1.318, h-index: 46)
Acta Endoscopica     Hybrid Journal   (Followers: 1, SJR: 0.113, h-index: 8)
acta ethologica     Hybrid Journal   (Followers: 4, SJR: 0.465, h-index: 23)
Acta Geochimica     Hybrid Journal   (Followers: 3)
Acta Geodaetica et Geophysica     Hybrid Journal   (Followers: 1, SJR: 0.294, h-index: 13)
Acta Geotechnica     Hybrid Journal   (Followers: 6, SJR: 1.818, h-index: 22)
Acta Informatica     Hybrid Journal   (Followers: 5, SJR: 0.524, h-index: 32)
Acta Mathematica     Hybrid Journal   (Followers: 9, SJR: 8.021, h-index: 47)
Acta Mathematica Hungarica     Hybrid Journal   (Followers: 2, SJR: 0.53, h-index: 29)
Acta Mathematica Sinica, English Series     Hybrid Journal   (Followers: 5, SJR: 0.406, h-index: 30)
Acta Mathematica Vietnamica     Hybrid Journal   (SJR: 0.451, h-index: 5)
Acta Mathematicae Applicatae Sinica, English Series     Hybrid Journal   (SJR: 0.22, h-index: 20)
Acta Mechanica     Hybrid Journal   (Followers: 18, SJR: 0.898, h-index: 52)
Acta Mechanica Sinica     Hybrid Journal   (Followers: 4, SJR: 0.426, h-index: 29)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 5, SJR: 0.525, h-index: 18)
Acta Meteorologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.524, h-index: 14)
Acta Neurochirurgica     Hybrid Journal   (Followers: 7, SJR: 0.833, h-index: 73)
Acta Neurologica Belgica     Hybrid Journal   (SJR: 0.348, h-index: 27)
Acta Neuropathologica     Hybrid Journal   (Followers: 3, SJR: 6.61, h-index: 117)
Acta Oceanologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.295, h-index: 17)
Acta Parasitologica     Hybrid Journal   (Followers: 9, SJR: 0.581, h-index: 28)
Acta Physiologiae Plantarum     Hybrid Journal   (Followers: 2, SJR: 0.551, h-index: 39)
Acta Politica     Hybrid Journal   (Followers: 13, SJR: 0.658, h-index: 20)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 5, SJR: 0.103, h-index: 4)
ADHD Attention Deficit and Hyperactivity Disorders     Hybrid Journal   (Followers: 20, SJR: 0.871, h-index: 15)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 7)
Administration and Policy in Mental Health and Mental Health Services Research     Partially Free   (Followers: 15, SJR: 0.795, h-index: 40)
Adsorption     Hybrid Journal   (Followers: 4, SJR: 0.774, h-index: 52)
Advances in Applied Clifford Algebras     Hybrid Journal   (Followers: 3, SJR: 0.319, h-index: 15)
Advances in Atmospheric Sciences     Hybrid Journal   (Followers: 34, SJR: 0.959, h-index: 44)
Advances in Computational Mathematics     Hybrid Journal   (Followers: 15, SJR: 1.255, h-index: 44)
Advances in Contraception     Hybrid Journal   (Followers: 2)
Advances in Data Analysis and Classification     Hybrid Journal   (Followers: 48, SJR: 1.113, h-index: 14)
Advances in Gerontology     Partially Free   (Followers: 7, SJR: 0.141, h-index: 3)
Advances in Health Sciences Education     Hybrid Journal   (Followers: 23, SJR: 1.397, h-index: 42)
Advances in Manufacturing     Hybrid Journal   (Followers: 3, SJR: 0.2, h-index: 4)
Advances in Polymer Science     Hybrid Journal   (Followers: 40, SJR: 0.637, h-index: 89)
Advances in Therapy     Hybrid Journal   (Followers: 6, SJR: 0.79, h-index: 44)
Aegean Review of the Law of the Sea and Maritime Law     Hybrid Journal   (Followers: 7)
Aequationes Mathematicae     Hybrid Journal   (Followers: 2, SJR: 0.882, h-index: 23)
Aerobiologia     Hybrid Journal   (Followers: 1, SJR: 0.511, h-index: 36)
Aesthetic Plastic Surgery     Hybrid Journal   (Followers: 8, SJR: 0.821, h-index: 49)
African Archaeological Review     Hybrid Journal   (Followers: 14, SJR: 0.612, h-index: 24)
Afrika Matematika     Hybrid Journal   (Followers: 1, SJR: 0.248, h-index: 6)
AGE     Hybrid Journal   (Followers: 7, SJR: 1.358, h-index: 33)
Ageing Intl.     Hybrid Journal   (Followers: 6, SJR: 0.337, h-index: 10)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
Aging Clinical and Experimental Research     Hybrid Journal   (Followers: 3, SJR: 0.529, h-index: 55)
Agricultural Research     Hybrid Journal   (Followers: 3)
Agriculture and Human Values     Hybrid Journal   (Followers: 12, SJR: 1.197, h-index: 49)
Agroforestry Systems     Hybrid Journal   (Followers: 20, SJR: 0.64, h-index: 56)
Agronomy for Sustainable Development     Hybrid Journal   (Followers: 10, SJR: 1.732, h-index: 59)
AI & Society     Hybrid Journal   (Followers: 7, SJR: 0.171, h-index: 19)
AIDS and Behavior     Hybrid Journal   (Followers: 13, SJR: 2.006, h-index: 71)
Air Quality, Atmosphere & Health     Hybrid Journal   (Followers: 2, SJR: 0.706, h-index: 19)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Algebra and Logic     Hybrid Journal   (Followers: 2, SJR: 0.566, h-index: 18)
Algebra Universalis     Hybrid Journal   (Followers: 2, SJR: 0.388, h-index: 22)
Algebras and Representation Theory     Hybrid Journal   (SJR: 0.868, h-index: 20)
Algorithmica     Hybrid Journal   (Followers: 7, SJR: 0.898, h-index: 56)
Allergo J.     Full-text available via subscription   (Followers: 1, SJR: 0.183, h-index: 20)
Allergo J. Intl.     Hybrid Journal   (Followers: 2)
Alpine Botany     Hybrid Journal   (Followers: 3, SJR: 0.729, h-index: 20)
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 3, SJR: 1.392, h-index: 32)
AMBIO     Hybrid Journal   (Followers: 14, SJR: 1.094, h-index: 87)
American J. of Cardiovascular Drugs     Hybrid Journal   (Followers: 10, SJR: 0.864, h-index: 39)
American J. of Community Psychology     Hybrid Journal   (Followers: 24, SJR: 1.237, h-index: 83)
American J. of Criminal Justice     Hybrid Journal   (Followers: 5, SJR: 0.634, h-index: 13)
American J. of Cultural Sociology     Hybrid Journal   (Followers: 11, SJR: 0.283, h-index: 3)
American J. of Dance Therapy     Hybrid Journal   (Followers: 4, SJR: 0.175, h-index: 13)
American J. of Potato Research     Hybrid Journal   (Followers: 2, SJR: 0.558, h-index: 35)
American J. of Psychoanalysis     Hybrid Journal   (Followers: 20, SJR: 0.293, h-index: 13)
American Sociologist     Hybrid Journal   (Followers: 10, SJR: 0.18, h-index: 13)
Amino Acids     Hybrid Journal   (Followers: 8, SJR: 1.362, h-index: 83)
AMS Review     Partially Free   (Followers: 4)
Analog Integrated Circuits and Signal Processing     Hybrid Journal   (Followers: 5, SJR: 0.21, h-index: 37)
Analysis and Mathematical Physics     Hybrid Journal   (Followers: 4, SJR: 0.665, h-index: 7)
Analysis in Theory and Applications     Hybrid Journal  
Analysis of Verbal Behavior     Hybrid Journal   (Followers: 4)
Analytical and Bioanalytical Chemistry     Hybrid Journal   (Followers: 32, SJR: 1.096, h-index: 123)
Anatomical Science Intl.     Hybrid Journal   (Followers: 2, SJR: 0.301, h-index: 26)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3, SJR: 2.212, h-index: 69)
Animal Cognition     Hybrid Journal   (Followers: 13, SJR: 1.122, h-index: 55)
Annales françaises de médecine d'urgence     Hybrid Journal   (Followers: 1, SJR: 0.156, h-index: 4)
Annales Henri Poincaré     Hybrid Journal   (Followers: 3, SJR: 1.377, h-index: 32)
Annales mathématiques du Québec     Hybrid Journal   (Followers: 4)
Annali dell'Universita di Ferrara     Hybrid Journal   (SJR: 0.504, h-index: 14)
Annali di Matematica Pura ed Applicata     Hybrid Journal   (Followers: 1, SJR: 1.167, h-index: 26)
Annals of Behavioral Medicine     Hybrid Journal   (Followers: 10, SJR: 2.112, h-index: 98)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18, SJR: 1.182, h-index: 94)
Annals of Combinatorics     Hybrid Journal   (Followers: 3, SJR: 0.849, h-index: 15)
Annals of Data Science     Hybrid Journal   (Followers: 8)
Annals of Dyslexia     Hybrid Journal   (Followers: 9, SJR: 0.857, h-index: 40)
Annals of Finance     Hybrid Journal   (Followers: 26, SJR: 0.686, h-index: 14)
Annals of Forest Science     Hybrid Journal   (Followers: 4, SJR: 0.929, h-index: 57)
Annals of Global Analysis and Geometry     Hybrid Journal   (Followers: 1, SJR: 1.136, h-index: 23)
Annals of Hematology     Hybrid Journal   (Followers: 13, SJR: 1.117, h-index: 62)
Annals of Mathematics and Artificial Intelligence     Hybrid Journal   (Followers: 6, SJR: 0.593, h-index: 42)
Annals of Microbiology     Hybrid Journal   (Followers: 9, SJR: 0.402, h-index: 26)
Annals of Nuclear Medicine     Hybrid Journal   (Followers: 5, SJR: 0.68, h-index: 45)
Annals of Operations Research     Hybrid Journal   (Followers: 8, SJR: 1.186, h-index: 78)
Annals of Regional Science     Hybrid Journal   (Followers: 7, SJR: 0.405, h-index: 42)
Annals of Software Engineering     Hybrid Journal   (Followers: 12)
Annals of Solid and Structural Mechanics     Hybrid Journal   (Followers: 9, SJR: 0.553, h-index: 8)
Annals of Surgical Oncology     Hybrid Journal   (Followers: 11, SJR: 1.902, h-index: 127)
Annals of Telecommunications     Hybrid Journal   (Followers: 7, SJR: 0.315, h-index: 25)
Annals of the Institute of Statistical Mathematics     Hybrid Journal   (Followers: 1, SJR: 0.931, h-index: 31)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 5, SJR: 0.992, h-index: 87)
Apidologie     Hybrid Journal   (Followers: 4, SJR: 1.14, h-index: 57)
APOPTOSIS     Hybrid Journal   (Followers: 7, SJR: 1.554, h-index: 87)
Applicable Algebra in Engineering, Communication and Computing     Hybrid Journal   (Followers: 2, SJR: 0.354, h-index: 27)
Applications of Mathematics     Hybrid Journal   (Followers: 1, SJR: 0.274, h-index: 20)
Applied Biochemistry and Biotechnology     Hybrid Journal   (Followers: 45, SJR: 0.575, h-index: 80)
Applied Biochemistry and Microbiology     Hybrid Journal   (Followers: 17, SJR: 0.267, h-index: 26)
Applied Categorical Structures     Hybrid Journal   (Followers: 2, SJR: 0.361, h-index: 21)
Applied Composite Materials     Hybrid Journal   (Followers: 45, SJR: 0.705, h-index: 35)
Applied Entomology and Zoology     Partially Free   (Followers: 2, SJR: 0.554, h-index: 34)
Applied Geomatics     Hybrid Journal   (Followers: 3, SJR: 0.323, h-index: 9)
Applied Geophysics     Hybrid Journal   (Followers: 7, SJR: 0.541, h-index: 13)
Applied Intelligence     Hybrid Journal   (Followers: 13, SJR: 0.777, h-index: 43)
Applied Magnetic Resonance     Hybrid Journal   (Followers: 3, SJR: 0.358, h-index: 34)
Applied Mathematics & Optimization     Hybrid Journal   (Followers: 4, SJR: 0.955, h-index: 33)
Applied Mathematics - A J. of Chinese Universities     Hybrid Journal   (SJR: 0.275, h-index: 8)
Applied Mathematics and Mechanics     Hybrid Journal   (Followers: 4, SJR: 0.37, h-index: 26)
Applied Microbiology and Biotechnology     Hybrid Journal   (Followers: 61, SJR: 1.262, h-index: 161)
Applied Physics A     Hybrid Journal   (Followers: 8, SJR: 0.535, h-index: 121)
Applied Physics B: Lasers and Optics     Hybrid Journal   (Followers: 22, SJR: 0.983, h-index: 104)
Applied Psychophysiology and Biofeedback     Hybrid Journal   (Followers: 5, SJR: 0.677, h-index: 47)
Applied Research in Quality of Life     Hybrid Journal   (Followers: 10, SJR: 0.288, h-index: 15)
Applied Solar Energy     Hybrid Journal   (Followers: 16, SJR: 0.251, h-index: 6)
Applied Spatial Analysis and Policy     Hybrid Journal   (Followers: 4, SJR: 0.351, h-index: 9)
Aquaculture Intl.     Hybrid Journal   (Followers: 21, SJR: 0.613, h-index: 40)
Aquarium Sciences and Conservation     Hybrid Journal   (Followers: 1)
Aquatic Ecology     Hybrid Journal   (Followers: 31, SJR: 0.646, h-index: 44)
Aquatic Geochemistry     Hybrid Journal   (Followers: 3, SJR: 0.764, h-index: 39)
Aquatic Sciences     Hybrid Journal   (Followers: 12, SJR: 1.172, h-index: 53)
Arabian J. for Science and Engineering     Hybrid Journal   (Followers: 5, SJR: 0.345, h-index: 20)
Arabian J. of Geosciences     Hybrid Journal   (Followers: 1, SJR: 0.417, h-index: 16)
Archaeological and Anthropological Sciences     Hybrid Journal   (Followers: 21, SJR: 1.056, h-index: 15)
Archaeologies     Hybrid Journal   (Followers: 12, SJR: 0.397, h-index: 13)
Archiv der Mathematik     Hybrid Journal   (SJR: 0.597, h-index: 29)
Archival Science     Hybrid Journal   (Followers: 51, SJR: 0.804, h-index: 22)
Archive for History of Exact Sciences     Hybrid Journal   (Followers: 7, SJR: 0.28, h-index: 15)
Archive for Mathematical Logic     Hybrid Journal   (Followers: 1, SJR: 0.946, h-index: 23)
Archive for Rational Mechanics and Analysis     Hybrid Journal   (SJR: 4.091, h-index: 66)
Archive of Applied Mechanics     Hybrid Journal   (Followers: 4, SJR: 0.865, h-index: 40)
Archives of Computational Methods in Engineering     Hybrid Journal   (Followers: 4, SJR: 2.841, h-index: 40)
Archives of Dermatological Research     Hybrid Journal   (Followers: 6, SJR: 0.9, h-index: 65)
Archives of Environmental Contamination and Toxicology     Hybrid Journal   (Followers: 10, SJR: 0.846, h-index: 84)
Archives of Gynecology and Obstetrics     Hybrid Journal   (Followers: 16, SJR: 0.695, h-index: 47)
Archives of Microbiology     Hybrid Journal   (Followers: 8, SJR: 0.702, h-index: 85)
Archives of Orthopaedic and Trauma Surgery     Hybrid Journal   (Followers: 8, SJR: 1.039, h-index: 56)
Archives of Osteoporosis     Hybrid Journal   (Followers: 2, SJR: 1.092, h-index: 13)
Archives of Sexual Behavior     Hybrid Journal   (Followers: 9, SJR: 1.198, h-index: 74)
Archives of Toxicology     Hybrid Journal   (Followers: 16, SJR: 1.595, h-index: 76)
Archives of Virology     Hybrid Journal   (Followers: 4, SJR: 1.086, h-index: 90)
Archives of Women's Mental Health     Hybrid Journal   (Followers: 13, SJR: 1.264, h-index: 50)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2, SJR: 1.2, h-index: 42)
ArgoSpine News & J.     Hybrid Journal   (SJR: 0.102, h-index: 3)
Argumentation     Hybrid Journal   (Followers: 4, SJR: 0.295, h-index: 18)
Arid Ecosystems     Hybrid Journal   (Followers: 3)
Arkiv för Matematik     Hybrid Journal   (SJR: 0.948, h-index: 22)
Arnold Mathematical J.     Hybrid Journal   (Followers: 1)
Arthropod-Plant Interactions     Hybrid Journal   (Followers: 2, SJR: 0.797, h-index: 17)
Arthroskopie     Hybrid Journal   (Followers: 1, SJR: 0.145, h-index: 8)
Artificial Intelligence and Law     Hybrid Journal   (Followers: 8, SJR: 0.288, h-index: 25)
Artificial Intelligence Review     Hybrid Journal   (Followers: 15, SJR: 0.948, h-index: 48)
Artificial Life and Robotics     Hybrid Journal   (Followers: 8, SJR: 0.231, h-index: 14)
Asia Europe J.     Hybrid Journal   (Followers: 4, SJR: 0.247, h-index: 9)
Asia Pacific Education Review     Hybrid Journal   (Followers: 9, SJR: 0.371, h-index: 17)
Asia Pacific J. of Management     Hybrid Journal   (Followers: 11, SJR: 1.676, h-index: 50)
Asia-Pacific Education Researcher     Hybrid Journal   (Followers: 11, SJR: 0.353, h-index: 13)
Asia-Pacific Financial Markets     Hybrid Journal   (Followers: 2, SJR: 0.19, h-index: 15)
Asia-Pacific J. of Atmospheric Sciences     Hybrid Journal   (Followers: 20, SJR: 1.006, h-index: 14)
Asian Business & Management     Hybrid Journal   (Followers: 7, SJR: 0.41, h-index: 10)
Asian J. of Business Ethics     Hybrid Journal   (Followers: 7)
Asian J. of Criminology     Hybrid Journal   (Followers: 5, SJR: 0.263, h-index: 8)
AStA Advances in Statistical Analysis     Hybrid Journal   (Followers: 2, SJR: 0.681, h-index: 15)
AStA Wirtschafts- und Sozialstatistisches Archiv     Hybrid Journal   (Followers: 5, SJR: 0.195, h-index: 5)
ästhetische dermatologie & kosmetologie     Full-text available via subscription  
Astronomy and Astrophysics Review     Hybrid Journal   (Followers: 21, SJR: 4.511, h-index: 44)
Astronomy Letters     Hybrid Journal   (Followers: 19, SJR: 0.58, h-index: 30)
Astronomy Reports     Hybrid Journal   (Followers: 12, SJR: 0.473, h-index: 23)
Astrophysical Bulletin     Hybrid Journal   (Followers: 2, SJR: 0.469, h-index: 11)
Astrophysics     Hybrid Journal   (Followers: 22, SJR: 0.243, h-index: 11)

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Journal Cover Advances in Gerontology
  [SJR: 0.141]   [H-I: 3]   [7 followers]  Follow
    
   Partially Free Journal Partially Free Journal
   ISSN (Print) 2079-0570 - ISSN (Online) 2079-0589
   Published by Springer-Verlag Homepage  [2335 journals]
  • Lifespan, longevity, and incidence of violent death in writers and poets
    • Authors: G. M. Zharinov; V. N. Anisimov
      Pages: 265 - 271
      Abstract: This article provides information on the mean age of death (MAD) in 26679 persons professionally involved in literary work (22028 men and 4651 women) that were related to one of three categories: novelists, poets, and writer-poets. Women from any of the investigated categories reliably lived longer than men (p < 0.02). Analysis of the dynamics of MAD starting from the 15th century AD to the end of the 20th century showed that this parameter increased among novelists and writer-poets of both genders gradually but unevenly; however, they remained unchanged among poets and poetesses. Among men, 5.38% of novelists and 3.01% of writer-poets were long-livers (90+ years), whereas their share among women was 12.35 and 8.96%, respectively. The centenary border was surmounted by 1.62% of women novelists and 0.61% of poetesses, whereas among men it was surpassed by 0.31% of novelists and 0.49% of writer-poets. The frequency of violent deaths (murders, suicides, and accidents) also differed and was the highest among poets and least among novelists; writer-poets occupied the intermediate position by these indicators. The MAD histograms had a two-mode type that is typical for heterogeneous samples; the novelist sample was weakly heterogeneous, and the poet sample was very noticeably heterogeneous. It is assumed that MAD and longevity, as well as the frequency of violent death, are related to the processes associated with creativity.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040147
      Issue No: Vol. 6, No. 4 (2016)
       
  • Suppression of alternative telomere lengthening in cancer cells with
           reverse transcriptase inhibitors
    • Authors: I. E. Bondarev; V. Kh. Khavinson
      Pages: 272 - 274
      Abstract: Telomerase is a ribonucleoprotein enzyme that elongates telomeres and therefore maintains chromosomal stability in germ lines, as well as in the majority of cancer cells during cell doubling. However, up to 30% of human tumors of different types do not express telomerase but instead use an alternative lengthening of telomeres (ALT). Here we show that human tumor-derived ALT cell lines express a LINE-1 (L1) retrotransposon. This indicates its participation in telomere maintenance, possibly, by a slippage mechanism during telomeric DNA synthesis. Moreover, the suppression of L1-encoded reverse transcriptase activity by antisense strategy or treatment of ALT cells with reverse transcriptase inhibitor 3'-azido-2',3'-dideoxythymidine (AZT) induces progressive telomere shortening, arrest in G2 phase of the cell cycle, and, eventually, cancer cell death. This finding suggests a unique opportunity to cure cancer in a number of cases.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040020
      Issue No: Vol. 6, No. 4 (2016)
       
  • Lamin B1 and lamin B2 in human skin in the process of aging
    • Authors: N. N. Golubtsova; F. N. Filippov; A. G. Gunin
      Pages: 275 - 281
      Abstract: The goal of this work was to study type B lamins in human skin at different ages. Lamins B1 and B2 were detected in sections of the skin by indirect immunohistochemistry. There were 62.3% of dermal fibroblasts with positive staining for lamin B1 at the period from 20 to 40 weeks of gestation. From birth to 40 years, 41–42% of fibroblasts containing lamin B1 were found in the dermis. In the age interval from 41 to 85 years, 57–60% of dermal fibroblasts had positive staining for lamin B1. The number of fibroblasts containing lamin B2 was gradually decreasing from 80.6 to 68.6% for ages from 20 weeks of gestation to 85 years. The expression of lamin B1 in the nuclei of fibroblasts decreased from birth to 40 years. The lamin B2 content in fibroblast nuclei was almost constant from 20 weeks of gestation to 85 years. The total number of fibroblasts in the dermis diminished with age. The most significant decrease in the number of fibroblasts was observed for ages from 20 weeks of gestation to 20 years. The results make it possible to suggest the participation of lamin B1 in triggering the age-dependent decrease in the number of fibroblasts in the human dermis.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040068
      Issue No: Vol. 6, No. 4 (2016)
       
  • Age-related changes in the structure of lymphoid organs: A review of the
           literature
    • Authors: I. V. Maiborodin; M. K. Agzaev; T. M. Ragimova; I. I. Maiborodin
      Pages: 282 - 290
      Abstract: Numerous and rather contradictory research data demonstrate that the mechanism of increased susceptibility to diseases in old age so far has no satisfactory explanation. Concurrently, the relevant literature almost lacks any comparative data on the specific features on the effect of surgeries and traumas on the structure and function of lymphoid organs in patients of different age cohorts. However, lymph nodes mark the activity of local inflammation, and changes in them allow the estimation of treatment efficiency, as well as the prognosis and prevention of many complications. This is especially important with the constant increase in the average age and life expectancy in the human population and the more active use of surgeries in elder and old patients.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040081
      Issue No: Vol. 6, No. 4 (2016)
       
  • Age-related changes in biogenic amine content and oxidative stress profile
           in rat hypothalamus with hyperhomocysteinemia
    • Authors: Yu. P. Milyutina; A. V. Pustygina; I. V. Zaloznyaya; A. V. Arutjunyan
      Pages: 291 - 297
      Abstract: The article presents a detailed analysis of correlations between the content of a variety of biogenic amines in the hypothalamic structures responsible for the gonadotropin-releasing hormone synthesis and secretion (the medial preoptic area and median eminence), and such independent factors as total L-homocysteine plasma level elevation induced by L-methionine loading and aging. Both the nature and pattern of changes in oxidative stress profile were evaluated. It was shown that aging, when compared to hyperhomocysteinemia, is a determining factor influencing the biogenic amine content in the studied hypothalamic structures. Unlike the antioxidant defense system profile, no considerable changes in macromolecule oxidative modification were found, which is evidence of a balanced activity of pro- and antioxidant systems in the hypothalamus.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040111
      Issue No: Vol. 6, No. 4 (2016)
       
  • Age-related features in expression of calcium-binding proteins in
           autonomic ganglionic neurons
    • Authors: P. M. Masliukov; A. D. Nozdrachev; A. I. Emanuilov
      Pages: 298 - 303
      Abstract: Calbindin 28 kDa (CB), calretinin (CR), and parvalbumin (PB) are calcium-binding proteins that are widely distributed in the nervous system and selectively expressed in certain population of neurons. These proteins are expressed not only in the central nervous system but also the autonomic ganglia. CB and PB are found in the sympathetic ganglia of rodents, and CB and CR are found in metasympathetic intramural ganglia. Their functions are poorly understood, but one can suggest that they have an important role in the regulation of Ca2+ levels in the cell. Calcium-binding proteins also play an important role in the age-related development of autonomic neurons. The percentage of CB- and CR-immunopositive neurons in the metasympathetic intramural ganglia of the small intestine in early postnatal development increases, whereas the percentage of CB decreases in sympathetic ganglia. It is possible that the functional meaning of such changes may be associated with the role of calcium currents in the development of neurons and the synaptic transmission.
      PubDate: 2016-10-01
      DOI: 10.1134/s207905701604010x
      Issue No: Vol. 6, No. 4 (2016)
       
  • Neurohumoral changes in rats of different age groups on the background of
           injection of cryopreserved cord blood nucleated cells
    • Authors: Yu. V. Martynova; V. G. Babiychuk; L. A. Sirotenko; N. G. Malova; L. V. Babiychuk
      Pages: 304 - 310
      Abstract: The application of a cryopreserved preparation of UCB NCs to rats was accompanied by enhanced activity of all neurohumoral regulation elements of heart rate, although the absolute parameters in 18- and 24-month-old animals did not reach values similar to those in groups of younger age. We also noticed an increase of the thyroid hormone concentration in the blood serum of the old rats. The concentration decreased with age. In addition, it was shown that the injection of UCB NCs during the animal’s life cycle (every 6 months) made it possible to maintain a functional state of the autonomous nervous system at a “young” physiological level.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040093
      Issue No: Vol. 6, No. 4 (2016)
       
  • Changes in the hormonal status of cardiovascular and the thyroid systems
           in rats with 18-month type 2 diabetes mellitus
    • Authors: K. V. Derkach; P. A. Ignatieva; I. V. Bogush; M. F. Balluzek; A. O. Shpakov
      Pages: 311 - 316
      Abstract: Among the most common complications of type 2 diabetes mellitus (DM2) are disorders of the cardiovascular and the thyroid systems. The functions of these systems may be weakened with increasing age. However, the mechanisms of these disorders, including the role of alterations in the adenylyl cyclase signaling system (ACSS), are not fully elucidated. The objective was to study the thyroid status and ACSS activity of the myocardium and the thyroid gland (TG) of rats with 8- and 18-month DM2 (DM-8 and DM-18) as compared to control animals of the same age (C-8 and C-18). In the myocardium of rats with DM2, an imbalance of β-adrenergic regulation of ACSS was detected, and these disturbances were amplified with increasing age. In the myocardium of rats of the C-18 group, disturbances of ACSS hormonal regulation were also identified but they were less pronounced. In diabetic rats, the levels of free thyroxine and total triiodothyronine decreased, the level of thyroid stimulating hormone (TSH) increased, and the stimulatory effect of TSH on the ACSS in TG was attenuated, which indicates the hypothyroid state in long-term DM2. In the C-18 group, these changes were absent. Thus, in the myocardium and TG of rats with 18-month DM2, the hormonal regulation of ACSS was violated, which may be one of the causes of cardiovascular pathology and hypothyroid states in long-term DM2.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040044
      Issue No: Vol. 6, No. 4 (2016)
       
  • Geriatric aspects in oncocoloproctology (review)
    • Authors: A. A. Sazonov; N. A. Maistrenko
      Pages: 317 - 321
      Abstract: Severe comorbidity significantly limits the application of active surgical tactics with respect to colorectal cancer (CRC) patients of older age groups, leading to the abandonment of necessary radical operations in 20% of cases. Low indicators of the application of adequate surgical tactics are by no means always due to objective difficulties; they may often be caused by the stereotypical approach to solving the problem of treatment of elderly patients, which leads to the unreasonable refusal of surgical intervention. To date, there is no unified concept of surgical treatment of colon cancer patients of elderly and senile age. There is no generally accepted system for determining functional operability in this group of patients, and no specific algorithms have been developed for their preoperative preparation and perioperative management. Therefore, one of the priorities in oncosurgery is the search for new approaches in the surgical treatment of gerontological CRC patients that will make it possible to increase the rate of execution of radical operations and, at the same time, decrease the number of postoperative complications in this numerous group of patients.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040123
      Issue No: Vol. 6, No. 4 (2016)
       
  • Luzindole accelerates the aging of estrous function of female rats
    • Authors: O. V. Zhukova; E. S. Obukhova; E. A. Khizhkin; V. A. Ilukha; I. A. Vinogradova
      Pages: 322 - 327
      Abstract: In this paper, we investigated the dynamics of aging of the estrous function of female rats kept in the conditions of standard vivarium lighting that received luzindolee—a blocker of melatonin receptors. Every three months, daily, for two weeks, vaginal smears were taken from the animals and a cytological examination of the vaginal contents was conducted. Despite the difference in the mechanisms of the development of melatonin system failure (a decreased production of melatonin and a blockade of melatonin receptors), the effects of the influence on the ovulatory function are similar. With a blockade of melatonin receptors, an appearance of premature signs of aging of the reproductive function in rats was observed. It was manifested by an increased duration of the ovulatory cycle; a decrease in the number of regular cycles; the emergence of irregular cycles; a decrease in the number of short estrous cycles and an increase of long cycles; and the early development of persistent estrus.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040159
      Issue No: Vol. 6, No. 4 (2016)
       
  • The effect of vascular peptide bioregulator on microcirculation in the
           brain cortex of old rats
    • Authors: I. B. Sokolova; I. V. Sergeev; G. A. Ryzhak; V. Kh. Khavinson
      Pages: 328 - 332
      Abstract: At a video facility for the study of intravital brain microcirculation, we found that, after a course treatment with vascular peptide bioregulator, the microvasculature density of the pial tunic in old (22–24 months) rats increased by about 2.5–2.8 times; the constriction and dilative reactions of the pial arterioles increased after the application of noradrenaline and acetylcholine onto the brain surface, respectively. However, perfusion into brain tissues did not increase, but the degree of oxygen saturation in microvessels of this tissue region increased.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040135
      Issue No: Vol. 6, No. 4 (2016)
       
  • Making use of J. Tanner’s scale of sexual dimorphism for assessment of
           the physical state of older women
    • Authors: S. N. Derevtsova; A. A. Romanenko; N. V. Tichonova
      Pages: 333 - 337
      Abstract: An assessment of the physical status of older women was performed based on anthropometry and bioelecytrical impedance analysis. The somatotype was determined with the use of J. Tanner’s index of sexual dimorphism (1951). In the surveyed sample, 46.15% women had a gynecomorphic body type manifested in the structural feminization of the skeletal system; masculinization of the skeletal system (andromorphism) was found in 4.74% of cases; and mild dysplasia towards the opposite sex was observed in 49.11% of older women, which corresponded to the mesomorphic somatotype. It was found that women with a gynecomorphic body type were significantly shorter than those with mesomorphic or andromorphic types; they had lower mass and transverse dimensions of the body. The largest absolute content of the fat mass and lean mass components were found in women with andromorphic body type, while the representatives of the sample with a gynecomorphic body type demonstrated the lowest values of these indicators of body composition. The results of anthropometric and bioimpedance measurements with allowance for the body type of elderly women involving J. Tanner’s index of sexual dimorphism reflect their adaptive capabilities and can serve as markers (predictors) of nonspecific somatic diseases.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040032
      Issue No: Vol. 6, No. 4 (2016)
       
  • System analysis of factors affecting the quality of life of aged people in
           their use of different forms of social services
    • Authors: E. Yu. Golubeva
      Pages: 338 - 342
      Abstract: The paper discusses factors influencing the satisfaction with quality of life (QoL) in aged and old people. QoL is considered in relation to the form of homecare and institutional care in urban and rural places. In rural places QoL is more dependent on the existence of and living with family than on the state of health or welfare position. In urban places, in special housing for lonely aged people and invalids, QoL is determined by the state of health, which allows independence in the fulfillment of everyday self-services. Under conditions of stationary services, the most important factor is the feeling of loneliness and isolation; this sometimes provokes the feelings of life fatigue and depression, which leads to alcohol abuse.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040056
      Issue No: Vol. 6, No. 4 (2016)
       
  • Quality of life for men of different ages in the European Russian North
           and its relationship with self-rated health and hormonal status
    • Authors: L. B. Kim; N. K. Belisheva; A. N. Putyatina; G. S. Russkikh; P. M. Kozhin; O. B. Tsypysheva
      Pages: 343 - 351
      Abstract: Assessment of the quality of life in male inhabitants of the European Russian North revealed decreased indices of the physical health component (the scale of role functioning determined by physical condition) and mental health component (the scales of social-role functioning and role functioning determined by emotional state and mental health) as compared to the inhabitants of Siberia as a control (comparison) group. Men aged under 29 had the highest scores at all scales. The scores decreased with age. The greatest reduction was observed for the scales of general well-being and bodily pain. There was a moderate decrease for the scales of physical functioning, role functioning determined by emotional state, and role functioning determined by physical condition. Quality of life was closely related to the northerners’ self-rated health, pathology index, molecular marker of aging, and biological age. A negative correlation between these values implies deterioration in the physical and mental health with biological age. The quality of life for the northerners also correlated with their hormonal status. There was a relationship between testosterone and three scales of physical health components, i.e., between cortisol and one scale of physical component and between both dehydroepiandrosterone sulfate and insulin and the scales of physical and mental components of health. The effect of various hormones on different age groups of northerners was demonstrated.
      PubDate: 2016-10-01
      DOI: 10.1134/s207905701604007x
      Issue No: Vol. 6, No. 4 (2016)
       
  • The gravitational field of the Earth: Geophysical factor of gerontology
           (Vorobeichikov effect)
    • Authors: S. N. Shapovalov
      Pages: 180 - 184
      Abstract: The paper presents the results of a study of the in vitro growth of Escherichia coli M17 involving the processing of observational data obtained by V.M. Vorobeichikov onboard the RV Akademik Fedorov while it sailed from St. Petersburg to Antarctica and back for the period from November 13, 2002, to May 26, 2003 (48th Russian Antarctic Expedition). Conclusions are drawn on the dependence of the in vitro growth rate of Escherichia coli on the geographical location change on a planetary scale. It does not exclude the dependence of other types of microorganisms on the spatial position in the gravitational field of the Earth. It is found that the Escherichia coli lag phase duration in the equatorial zone is close to its duration in the high-latitude Antarctic zone. Simultaneously, lag phase durations at the equator and in Antarctica correspond to the lag phase duration at the central phase of a lunar eclipse. It is concluded that in vitro Escherichia coli is highly sensitive to the gravitational field strength of the Earth and to the syzygy events.
      PubDate: 2016-07-01
      DOI: 10.1134/s2079057016030115
      Issue No: Vol. 6, No. 3 (2016)
       
  • Chaotic dynamics of cardio intervals in three age groups of indigenous and
           nonindigenous populations of Ugra
    • Authors: V. M. Eskov; A. A. Khadartsev; V. V. Eskov; J. V. Vokhmina
      Pages: 191 - 197
      Abstract: The issue of the life expectancy of indigenous and nonindigenous populations of the northern territories in the Russian Federation is analyzed in terms of economic growth and industrial development of the northern territories. The importance of prolonging the period of active working age of nonindigenous population of Khanty-Mansiysk Autonomous Okrug–Ugra and Yamalo-Nenetsky Autonomous Okrug is increasing. Four possible directions are presented for prolongation of the active life of the nonindigenous population. The problem of comparative dynamics of age-related changes in the cardiovascular system in three specific age groups of female indigenous and nonindigenous population is considered. A decrease in the volume of quasi-attractors in the phase space of states is equivalent to adding exercise stress, which is typical of normal aging. We offer a mathematical pattern to reduce these volumes in assessing the dynamics of human aging in the north.
      PubDate: 2016-07-01
      DOI: 10.1134/s2079057016030048
      Issue No: Vol. 6, No. 3 (2016)
       
  • Gene polymorphism and levels of pro-inflammatory cytokines in plasma and
           synovial fluid of patients with posttraumatic knee osteoarthritis
    • Authors: V. V. Vnukov; I. V. Krolevets; S. B. Panina; N. P. Milutina; A. A. Ananyan; A. B. Sagakyants; M. A. Zabrodin
      Pages: 198 - 203
      Abstract: Posttraumatic knee osteoarthritis patients (n = 117) and healthy individuals (n = 94) were investigated to determine the genotype and allelic frequency distribution of polymorphic loci Т-31С, С + 3953Т IL-1β and G-308A TNF-α. The plasma and synovial fluid levels of proinflammatory cytokines IL-1β and TNF-α were also measured in 31 patients. The study demonstrated that the plasma and synovial fluid levels of IL-1β but not TNF-α were increased in patients with posttraumatic knee osteoarthritis. Also, the linkage between TNF-α levels and polymorphic locus G-308A TNF-α was shown: the presence of allele–308А was associated with decreased TNF-α levels. It was found that polymorphic loci Т-31С, С+3953Т IL-1β, and G-308A TNF-α are not markers of predisposition to posttraumatic knee osteoarthritis in Russian population of Rostov Oblast.
      PubDate: 2016-07-01
      DOI: 10.1134/s2079057016030152
      Issue No: Vol. 6, No. 3 (2016)
       
  • Comparison of morphofunctional features of the ventral hippocampus in
           adult and old rats after combined stress
    • Authors: M. R. Ekova; A. V. Smirnov; M. V. Shmidt; I. N. Tyurenkov; E. V. Volotova; D. V. Kurkin; N. V. Grigorieva; V. V. Ermilov; D. S. Mednikov
      Pages: 204 - 211
      Abstract: Animals were exposed to 7 days of combined stress in a special device consisting of six isolated compartments of similar volumes. During the 30-min exposure, the stressors of various modalities, including pulse lighting, heavy sound, and vibration, were presented and stochastically changed every 5 min. This treatment was coincided with restraint and elevated temperature in the compartments. We observed more severe dystrophic lesion and highly expressed inducible nitric oxide synthase in neurons of the pyramidal layer of the CA3 field, signs of impaired blood flow, perivascular edema, and decreased expression of endothelial nitric oxide synthase in endothelial cells of the microvasculature, and lower expression of serine racemase in neuropil of the radial layer of the CA1 field in the ventral hippocampi after the exposure of 24-month-old rats to combined stress as compared to adult 12-month-old rats.
      PubDate: 2016-07-01
      DOI: 10.1134/s2079057016030036
      Issue No: Vol. 6, No. 3 (2016)
       
  • Disulfiram inhibits cataract development in OXYS rats
    • Authors: A. Zh. Fursova; Yu. V. Rumyantseva; N. G. Kolosova; S. A. Kedik; A. V. Panov; V. S. Tyukova
      Pages: 212 - 216
      Abstract: Surgical treatment remains the only way to restore vision in patients with cataract; this disorder is the most common cause of vision decline and vision loss in people older than 65. It is estimated that a 10-year delay in the development of a cataract will enable a twofold reduction in the need for surgery. In 2012 Nagai et al. reported an anticataract effect of the acetaldehyde dehydrogenase inhibitor disulfiram (DSF) (which is widely used as an antialcoholism drug) in ICR/f rats with hereditary cataracts. The goal of the present study was to evaluate the effect of DSF on cataract in OXYS rats. These rats develop lens alterations similar to senile cataract in humans. Administration of DSF from the age of 1.5 to 3.5 months did not prevent but significantly slowed cataract development in OXYS rats. At concentrations of 0.25 and 0.5%, DSF reduced the severity of pathological alterations in the lens by a factor of 1.8; at these concentrations, it was more effective than at a concentration of 1%. These data were in accordance with the results of ophthalmoscopic histomorphological examination, which showed that pharmacotherapy strongly reduced the structural damage (typical for cataracts) to the capsule of the lens epithelium and to the organization of its fibers. Thus, disulfiram is a promising drug for the prevention of senile cataract in humans.
      PubDate: 2016-07-01
      DOI: 10.1134/s207905701603005x
      Issue No: Vol. 6, No. 3 (2016)
       
  • Association of aging-related obesity and metabolic syndrome in men
    • Authors: B. B. Pinkhasov; V. G. Selyatitskaya; A. R. Karapetyan; Yu. V. Lutov
      Pages: 224 - 230
      Abstract: A study that involved 253 men (age 22–74 years) revealed an increase in the intensity of fat tissue accumulation at the beginning of the first period of middle age already; the increase was associated with the transition from the predominance of the gynoid type of obesity to that of the android type. The increase in the incidence of both individual components of metabolic syndrome and the syndrome as a whole was most pronounced in men in the second period of middle age, whereas the frequency of occurrence of such syndrome components as hypertriglyceridemia, low level of HDL cholesterol, and hyperglycemia was lower in the elderly. The value of the index of visceral obesity was significantly higher in men with the android type of obesity in all of the studied age groups. Thus, the risk of metabolic syndrome development in men with the gynoid type of obesity is lower than in men with the android type of obesity, regardless of the age of the subjects.
      PubDate: 2016-07-01
      DOI: 10.1134/s2079057016030085
      Issue No: Vol. 6, No. 3 (2016)
       
 
 
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