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Publisher: Springer-Verlag (Total: 2353 journals)

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Showing 1 - 200 of 2353 Journals sorted alphabetically
3D Research     Hybrid Journal   (Followers: 19, SJR: 0.214, h-index: 10)
4OR: A Quarterly J. of Operations Research     Hybrid Journal   (Followers: 9, SJR: 1.073, h-index: 25)
AAPS J.     Hybrid Journal   (Followers: 20, SJR: 1.192, h-index: 74)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6, SJR: 0.718, h-index: 54)
Abdominal Imaging     Hybrid Journal   (Followers: 14, SJR: 0.723, h-index: 60)
Abhandlungen aus dem Mathematischen Seminar der Universitat Hamburg     Hybrid Journal   (Followers: 3, SJR: 0.447, h-index: 12)
Academic Psychiatry     Full-text available via subscription   (Followers: 22, SJR: 0.492, h-index: 32)
Academic Questions     Hybrid Journal   (Followers: 7, SJR: 0.135, h-index: 6)
Accreditation and Quality Assurance: J. for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 26, SJR: 0.378, h-index: 30)
Acoustical Physics     Hybrid Journal   (Followers: 11, SJR: 0.355, h-index: 20)
Acoustics Australia     Hybrid Journal  
Acta Analytica     Hybrid Journal   (Followers: 7, SJR: 0.387, h-index: 6)
Acta Applicandae Mathematicae     Hybrid Journal   (Followers: 1, SJR: 0.624, h-index: 34)
Acta Biotheoretica     Hybrid Journal   (Followers: 5, SJR: 0.419, h-index: 25)
Acta Diabetologica     Hybrid Journal   (Followers: 14, SJR: 1.318, h-index: 46)
Acta Endoscopica     Hybrid Journal   (Followers: 1, SJR: 0.113, h-index: 8)
acta ethologica     Hybrid Journal   (Followers: 4, SJR: 0.465, h-index: 23)
Acta Geochimica     Hybrid Journal   (Followers: 4)
Acta Geodaetica et Geophysica     Hybrid Journal   (Followers: 1, SJR: 0.294, h-index: 13)
Acta Geotechnica     Hybrid Journal   (Followers: 7, SJR: 1.818, h-index: 22)
Acta Informatica     Hybrid Journal   (Followers: 5, SJR: 0.524, h-index: 32)
Acta Mathematica     Hybrid Journal   (Followers: 11, SJR: 8.021, h-index: 47)
Acta Mathematica Hungarica     Hybrid Journal   (Followers: 2, SJR: 0.53, h-index: 29)
Acta Mathematica Sinica, English Series     Hybrid Journal   (Followers: 5, SJR: 0.406, h-index: 30)
Acta Mathematica Vietnamica     Hybrid Journal   (SJR: 0.451, h-index: 5)
Acta Mathematicae Applicatae Sinica, English Series     Hybrid Journal   (SJR: 0.22, h-index: 20)
Acta Mechanica     Hybrid Journal   (Followers: 19, SJR: 0.898, h-index: 52)
Acta Mechanica Sinica     Hybrid Journal   (Followers: 5, SJR: 0.426, h-index: 29)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 5, SJR: 0.525, h-index: 18)
Acta Meteorologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.524, h-index: 14)
Acta Neurochirurgica     Hybrid Journal   (Followers: 6, SJR: 0.833, h-index: 73)
Acta Neurologica Belgica     Hybrid Journal   (SJR: 0.348, h-index: 27)
Acta Neuropathologica     Hybrid Journal   (Followers: 5, SJR: 6.61, h-index: 117)
Acta Oceanologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.295, h-index: 17)
Acta Parasitologica     Hybrid Journal   (Followers: 9, SJR: 0.581, h-index: 28)
Acta Physiologiae Plantarum     Hybrid Journal   (Followers: 2, SJR: 0.551, h-index: 39)
Acta Politica     Hybrid Journal   (Followers: 13, SJR: 0.658, h-index: 20)
Activitas Nervosa Superior     Hybrid Journal  
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 5, SJR: 0.103, h-index: 4)
ADHD Attention Deficit and Hyperactivity Disorders     Hybrid Journal   (Followers: 21, SJR: 0.871, h-index: 15)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 7)
Administration and Policy in Mental Health and Mental Health Services Research     Partially Free   (Followers: 15, SJR: 0.795, h-index: 40)
Adsorption     Hybrid Journal   (Followers: 4, SJR: 0.774, h-index: 52)
Advances in Applied Clifford Algebras     Hybrid Journal   (Followers: 3, SJR: 0.319, h-index: 15)
Advances in Atmospheric Sciences     Hybrid Journal   (Followers: 34, SJR: 0.959, h-index: 44)
Advances in Computational Mathematics     Hybrid Journal   (Followers: 15, SJR: 1.255, h-index: 44)
Advances in Contraception     Hybrid Journal   (Followers: 3)
Advances in Data Analysis and Classification     Hybrid Journal   (Followers: 53, SJR: 1.113, h-index: 14)
Advances in Gerontology     Partially Free   (Followers: 9, SJR: 0.141, h-index: 3)
Advances in Health Sciences Education     Hybrid Journal   (Followers: 22, SJR: 1.397, h-index: 42)
Advances in Manufacturing     Hybrid Journal   (Followers: 3, SJR: 0.2, h-index: 4)
Advances in Polymer Science     Hybrid Journal   (Followers: 41, SJR: 0.637, h-index: 89)
Advances in Therapy     Hybrid Journal   (Followers: 5, SJR: 0.79, h-index: 44)
Aegean Review of the Law of the Sea and Maritime Law     Hybrid Journal   (Followers: 7)
Aequationes Mathematicae     Hybrid Journal   (Followers: 2, SJR: 0.882, h-index: 23)
Aerobiologia     Hybrid Journal   (Followers: 1, SJR: 0.511, h-index: 36)
Aesthetic Plastic Surgery     Hybrid Journal   (Followers: 9, SJR: 0.821, h-index: 49)
African Archaeological Review     Hybrid Journal   (Followers: 15, SJR: 0.612, h-index: 24)
Afrika Matematika     Hybrid Journal   (Followers: 1, SJR: 0.248, h-index: 6)
AGE     Hybrid Journal   (Followers: 7, SJR: 1.358, h-index: 33)
Ageing Intl.     Hybrid Journal   (Followers: 7, SJR: 0.337, h-index: 10)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
Aging Clinical and Experimental Research     Hybrid Journal   (Followers: 3, SJR: 0.529, h-index: 55)
Agricultural Research     Hybrid Journal   (Followers: 3)
Agriculture and Human Values     Hybrid Journal   (Followers: 12, SJR: 1.197, h-index: 49)
Agroforestry Systems     Hybrid Journal   (Followers: 20, SJR: 0.64, h-index: 56)
Agronomy for Sustainable Development     Hybrid Journal   (Followers: 10, SJR: 1.732, h-index: 59)
AI & Society     Hybrid Journal   (Followers: 7, SJR: 0.171, h-index: 19)
AIDS and Behavior     Hybrid Journal   (Followers: 13, SJR: 2.006, h-index: 71)
Air Quality, Atmosphere & Health     Hybrid Journal   (Followers: 3, SJR: 0.706, h-index: 19)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Algebra and Logic     Hybrid Journal   (Followers: 4, SJR: 0.566, h-index: 18)
Algebra Universalis     Hybrid Journal   (Followers: 2, SJR: 0.388, h-index: 22)
Algebras and Representation Theory     Hybrid Journal   (Followers: 1, SJR: 0.868, h-index: 20)
Algorithmica     Hybrid Journal   (Followers: 8, SJR: 0.898, h-index: 56)
Allergo J.     Full-text available via subscription   (Followers: 1, SJR: 0.183, h-index: 20)
Allergo J. Intl.     Hybrid Journal   (Followers: 2)
Alpine Botany     Hybrid Journal   (Followers: 4, SJR: 0.729, h-index: 20)
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 3, SJR: 1.392, h-index: 32)
AMBIO     Hybrid Journal   (Followers: 15, SJR: 1.094, h-index: 87)
American J. of Cardiovascular Drugs     Hybrid Journal   (Followers: 13, SJR: 0.864, h-index: 39)
American J. of Community Psychology     Hybrid Journal   (Followers: 23, SJR: 1.237, h-index: 83)
American J. of Criminal Justice     Hybrid Journal   (Followers: 6, SJR: 0.634, h-index: 13)
American J. of Cultural Sociology     Hybrid Journal   (Followers: 11, SJR: 0.283, h-index: 3)
American J. of Dance Therapy     Hybrid Journal   (Followers: 4, SJR: 0.175, h-index: 13)
American J. of Potato Research     Hybrid Journal   (Followers: 2, SJR: 0.558, h-index: 35)
American J. of Psychoanalysis     Hybrid Journal   (Followers: 21, SJR: 0.293, h-index: 13)
American Sociologist     Hybrid Journal   (Followers: 12, SJR: 0.18, h-index: 13)
Amino Acids     Hybrid Journal   (Followers: 8, SJR: 1.362, h-index: 83)
AMS Review     Partially Free   (Followers: 4)
Analog Integrated Circuits and Signal Processing     Hybrid Journal   (Followers: 7, SJR: 0.21, h-index: 37)
Analysis and Mathematical Physics     Hybrid Journal   (Followers: 3, SJR: 0.665, h-index: 7)
Analysis in Theory and Applications     Hybrid Journal   (Followers: 1)
Analysis of Verbal Behavior     Hybrid Journal   (Followers: 5)
Analytical and Bioanalytical Chemistry     Hybrid Journal   (Followers: 29, SJR: 1.096, h-index: 123)
Anatomical Science Intl.     Hybrid Journal   (Followers: 2, SJR: 0.301, h-index: 26)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3, SJR: 2.212, h-index: 69)
Animal Cognition     Hybrid Journal   (Followers: 16, SJR: 1.122, h-index: 55)
Annales françaises de médecine d'urgence     Hybrid Journal   (Followers: 1, SJR: 0.156, h-index: 4)
Annales Henri Poincaré     Hybrid Journal   (Followers: 3, SJR: 1.377, h-index: 32)
Annales mathématiques du Québec     Hybrid Journal   (Followers: 4)
Annali dell'Universita di Ferrara     Hybrid Journal   (SJR: 0.504, h-index: 14)
Annali di Matematica Pura ed Applicata     Hybrid Journal   (Followers: 1, SJR: 1.167, h-index: 26)
Annals of Behavioral Medicine     Hybrid Journal   (Followers: 11, SJR: 2.112, h-index: 98)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18, SJR: 1.182, h-index: 94)
Annals of Combinatorics     Hybrid Journal   (Followers: 3, SJR: 0.849, h-index: 15)
Annals of Data Science     Hybrid Journal   (Followers: 9)
Annals of Dyslexia     Hybrid Journal   (Followers: 9, SJR: 0.857, h-index: 40)
Annals of Finance     Hybrid Journal   (Followers: 28, SJR: 0.686, h-index: 14)
Annals of Forest Science     Hybrid Journal   (Followers: 4, SJR: 0.929, h-index: 57)
Annals of Global Analysis and Geometry     Hybrid Journal   (Followers: 1, SJR: 1.136, h-index: 23)
Annals of Hematology     Hybrid Journal   (Followers: 14, SJR: 1.117, h-index: 62)
Annals of Mathematics and Artificial Intelligence     Hybrid Journal   (Followers: 6, SJR: 0.593, h-index: 42)
Annals of Microbiology     Hybrid Journal   (Followers: 10, SJR: 0.402, h-index: 26)
Annals of Nuclear Medicine     Hybrid Journal   (Followers: 5, SJR: 0.68, h-index: 45)
Annals of Operations Research     Hybrid Journal   (Followers: 8, SJR: 1.186, h-index: 78)
Annals of Ophthalmology     Hybrid Journal   (Followers: 11)
Annals of Regional Science     Hybrid Journal   (Followers: 7, SJR: 0.405, h-index: 42)
Annals of Software Engineering     Hybrid Journal   (Followers: 12)
Annals of Solid and Structural Mechanics     Hybrid Journal   (Followers: 10, SJR: 0.553, h-index: 8)
Annals of Surgical Oncology     Hybrid Journal   (Followers: 15, SJR: 1.902, h-index: 127)
Annals of Telecommunications     Hybrid Journal   (Followers: 7, SJR: 0.315, h-index: 25)
Annals of the Institute of Statistical Mathematics     Hybrid Journal   (Followers: 1, SJR: 0.931, h-index: 31)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 5, SJR: 0.992, h-index: 87)
Apidologie     Hybrid Journal   (Followers: 4, SJR: 1.14, h-index: 57)
APOPTOSIS     Hybrid Journal   (Followers: 8, SJR: 1.554, h-index: 87)
Applicable Algebra in Engineering, Communication and Computing     Hybrid Journal   (Followers: 2, SJR: 0.354, h-index: 27)
Applications of Mathematics     Hybrid Journal   (Followers: 1, SJR: 0.274, h-index: 20)
Applied Biochemistry and Biotechnology     Hybrid Journal   (Followers: 44, SJR: 0.575, h-index: 80)
Applied Biochemistry and Microbiology     Hybrid Journal   (Followers: 17, SJR: 0.267, h-index: 26)
Applied Cancer Research     Open Access  
Applied Categorical Structures     Hybrid Journal   (Followers: 2, SJR: 0.361, h-index: 21)
Applied Composite Materials     Hybrid Journal   (Followers: 48, SJR: 0.705, h-index: 35)
Applied Entomology and Zoology     Partially Free   (Followers: 2, SJR: 0.554, h-index: 34)
Applied Geomatics     Hybrid Journal   (Followers: 3, SJR: 0.323, h-index: 9)
Applied Geophysics     Hybrid Journal   (Followers: 8, SJR: 0.541, h-index: 13)
Applied Intelligence     Hybrid Journal   (Followers: 11, SJR: 0.777, h-index: 43)
Applied Magnetic Resonance     Hybrid Journal   (Followers: 4, SJR: 0.358, h-index: 34)
Applied Mathematics & Optimization     Hybrid Journal   (Followers: 4, SJR: 0.955, h-index: 33)
Applied Mathematics - A J. of Chinese Universities     Hybrid Journal   (SJR: 0.275, h-index: 8)
Applied Mathematics and Mechanics     Hybrid Journal   (Followers: 4, SJR: 0.37, h-index: 26)
Applied Microbiology and Biotechnology     Hybrid Journal   (Followers: 62, SJR: 1.262, h-index: 161)
Applied Physics A     Hybrid Journal   (Followers: 7, SJR: 0.535, h-index: 121)
Applied Physics B: Lasers and Optics     Hybrid Journal   (Followers: 23, SJR: 0.983, h-index: 104)
Applied Psychophysiology and Biofeedback     Hybrid Journal   (Followers: 8, SJR: 0.677, h-index: 47)
Applied Research in Quality of Life     Hybrid Journal   (Followers: 10, SJR: 0.288, h-index: 15)
Applied Solar Energy     Hybrid Journal   (Followers: 17, SJR: 0.251, h-index: 6)
Applied Spatial Analysis and Policy     Hybrid Journal   (Followers: 4, SJR: 0.351, h-index: 9)
Aquaculture Intl.     Hybrid Journal   (Followers: 22, SJR: 0.613, h-index: 40)
Aquarium Sciences and Conservation     Hybrid Journal   (Followers: 1)
Aquatic Ecology     Hybrid Journal   (Followers: 30, SJR: 0.646, h-index: 44)
Aquatic Geochemistry     Hybrid Journal   (Followers: 4, SJR: 0.764, h-index: 39)
Aquatic Sciences     Hybrid Journal   (Followers: 12, SJR: 1.172, h-index: 53)
Arabian J. for Science and Engineering     Hybrid Journal   (Followers: 5, SJR: 0.345, h-index: 20)
Arabian J. of Geosciences     Hybrid Journal   (Followers: 1, SJR: 0.417, h-index: 16)
Archaeological and Anthropological Sciences     Hybrid Journal   (Followers: 22, SJR: 1.056, h-index: 15)
Archaeologies     Hybrid Journal   (Followers: 12, SJR: 0.397, h-index: 13)
Archiv der Mathematik     Hybrid Journal   (Followers: 1, SJR: 0.597, h-index: 29)
Archival Science     Hybrid Journal   (Followers: 53, SJR: 0.804, h-index: 22)
Archive for History of Exact Sciences     Hybrid Journal   (Followers: 7, SJR: 0.28, h-index: 15)
Archive for Mathematical Logic     Hybrid Journal   (Followers: 1, SJR: 0.946, h-index: 23)
Archive for Rational Mechanics and Analysis     Hybrid Journal   (SJR: 4.091, h-index: 66)
Archive of Applied Mechanics     Hybrid Journal   (Followers: 5, SJR: 0.865, h-index: 40)
Archives and Museum Informatics     Hybrid Journal   (Followers: 124)
Archives of Computational Methods in Engineering     Hybrid Journal   (Followers: 4, SJR: 2.841, h-index: 40)
Archives of Dermatological Research     Hybrid Journal   (Followers: 6, SJR: 0.9, h-index: 65)
Archives of Environmental Contamination and Toxicology     Hybrid Journal   (Followers: 9, SJR: 0.846, h-index: 84)
Archives of Gynecology and Obstetrics     Hybrid Journal   (Followers: 17, SJR: 0.695, h-index: 47)
Archives of Microbiology     Hybrid Journal   (Followers: 8, SJR: 0.702, h-index: 85)
Archives of Orthopaedic and Trauma Surgery     Hybrid Journal   (Followers: 8, SJR: 1.039, h-index: 56)
Archives of Osteoporosis     Hybrid Journal   (Followers: 2, SJR: 1.092, h-index: 13)
Archives of Sexual Behavior     Hybrid Journal   (Followers: 9, SJR: 1.198, h-index: 74)
Archives of Toxicology     Hybrid Journal   (Followers: 16, SJR: 1.595, h-index: 76)
Archives of Virology     Hybrid Journal   (Followers: 5, SJR: 1.086, h-index: 90)
Archives of Women's Mental Health     Hybrid Journal   (Followers: 14, SJR: 1.264, h-index: 50)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2, SJR: 1.2, h-index: 42)
ArgoSpine News & J.     Hybrid Journal   (SJR: 0.102, h-index: 3)
Argumentation     Hybrid Journal   (Followers: 5, SJR: 0.295, h-index: 18)
Arid Ecosystems     Hybrid Journal   (Followers: 3)
Arkiv för Matematik     Hybrid Journal   (Followers: 1, SJR: 0.948, h-index: 22)
Arnold Mathematical J.     Hybrid Journal   (Followers: 1)
Arthropod-Plant Interactions     Hybrid Journal   (Followers: 1, SJR: 0.797, h-index: 17)
Arthroskopie     Hybrid Journal   (Followers: 1, SJR: 0.145, h-index: 8)
Artificial Intelligence and Law     Hybrid Journal   (Followers: 10, SJR: 0.288, h-index: 25)
Artificial Intelligence Review     Hybrid Journal   (Followers: 14, SJR: 0.948, h-index: 48)
Artificial Life and Robotics     Hybrid Journal   (Followers: 8, SJR: 0.231, h-index: 14)
Asia Europe J.     Hybrid Journal   (Followers: 4, SJR: 0.247, h-index: 9)
Asia Pacific Education Review     Hybrid Journal   (Followers: 9, SJR: 0.371, h-index: 17)
Asia Pacific J. of Management     Hybrid Journal   (Followers: 14, SJR: 1.676, h-index: 50)
Asia-Pacific Education Researcher     Hybrid Journal   (Followers: 11, SJR: 0.353, h-index: 13)
Asia-Pacific Financial Markets     Hybrid Journal   (Followers: 2, SJR: 0.19, h-index: 15)
Asia-Pacific J. of Atmospheric Sciences     Hybrid Journal   (Followers: 20, SJR: 1.006, h-index: 14)
Asian Business & Management     Hybrid Journal   (Followers: 7, SJR: 0.41, h-index: 10)
Asian J. of Business Ethics     Hybrid Journal   (Followers: 7)
Asian J. of Criminology     Hybrid Journal   (Followers: 5, SJR: 0.263, h-index: 8)
AStA Advances in Statistical Analysis     Hybrid Journal   (Followers: 2, SJR: 0.681, h-index: 15)
AStA Wirtschafts- und Sozialstatistisches Archiv     Hybrid Journal   (Followers: 5, SJR: 0.195, h-index: 5)
ästhetische dermatologie & kosmetologie     Full-text available via subscription  

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Journal Cover Advances in Gerontology
  [SJR: 0.141]   [H-I: 3]   [9 followers]  Follow
    
   Partially Free Journal Partially Free Journal
   ISSN (Print) 2079-0570 - ISSN (Online) 2079-0589
   Published by Springer-Verlag Homepage  [2353 journals]
  • Aging of dogs and Drosophila as described based on the kinetic theory
    • Authors: A. A. Viktorov; V. D. Gladkikh; E. E. Morozova
      Pages: 177 - 183
      Abstract: Abstract The goal of this study is to assess the adequacy of models assumed in the kinetic theory of aging of living systems, which is based on the analysis of data obtained on dogs and fruit flies. The mathematical model of the kinetic theory of aging was demonstrated to describe the probability density of death, probability of death, and the average longevity of the biological systems studied. These systems were considered in their natural environments and under conditions of short-term chronic irradiation and elevated temperature in the case of dogs and flies, respectively. The aging kinetic equations and their parameters are represented.
      PubDate: 2017-07-01
      DOI: 10.1134/s2079057017030134
      Issue No: Vol. 7, No. 3 (2017)
       
  • Endocrinology of cancer and age: Early and late developmental stages
    • Authors: L. M. Berstein
      Pages: 184 - 194
      Abstract: Abstract Processes essential for hormone-dependent carcinogenesis occur at different developmental stages, even the earliest. Early deviations in the hormone–metabolic status often inversely correlate with the risk of common age-associated noncommunicable diseases, in particular, tumors in hormone-dependent tissues and cardiovascular disorders. Another paradox is the increase in reproductive system tumor incidence at the age associated with lower production of mitogenic hormones. Therefore, one should take into account the production of steroids directly in target tissues and recognize the importance of the progenotoxic effect of estrogens and their derivatives. Another noteworthy aspect is the role of endocrine–genotoxic switchings, which form the so-called basic triad, generated by age-associated endocrine shifts and environmental factors. In addition to the steroid-dependent set of cancer risk factors, attention should be paid to nonsteroid ones (such as those associated with insulin resistance or inflammatory cytokines), since they are tightly connected with the immune system functional state, mild chronic inflammation, obesity phenotype, and pro-/antiinflammatory lipid factor ratio. All these considerations confirm the importance of timely preventive interventions at early and late developmental stages, which are often several decades apart.
      PubDate: 2017-07-01
      DOI: 10.1134/s2079057017030055
      Issue No: Vol. 7, No. 3 (2017)
       
  • Role of ceramide in the aging-related decrease of cardiolipin content in
           the rat heart
    • Authors: N. A. Babenko; G. V. Storozhenko
      Pages: 195 - 200
      Abstract: Abstract Ceramide accumulation and a decrease of cardiolipin level in cardiomyocytes are among the key reasons of mitochondrial dysfunction and the emergence of heart failure. Ceramide has a significant effect on cardiolipin metabolism, and, therefore, the aim of the present study was to assess the role of ceramide in the aging-related decrease of cardiolipin content in the rat heart. Young (sexually mature), adult, and old (3-, 12-, 24-, 30-, and 34-month-old) Wistar male rats were used in the study. A considerable decrease in the content of cardiolipin during aging was accompanied by accumulation of phosphatidic acid, a precursor of cardiolipin. Doxorubicin administration to the rats or the perfusion of an isolated heart with a buffer solution supplemented with C16-ceramide evoked an increase in ceramide levels and a decrease in the level of cardiolipin in the heart of 3-month-old rats. The reduction of ceramide content in the hearts of 24-month-old rats by means of administration of melipramine and zoledronic acid that inhibit acidic sphingomyelinase led to an increase in cardiolipin levels. The results point at a certain contribution of sphingomyelinase-dependent ceramide accumulation to the aging-related decrease of cardiolipin content that can lead to disturbances of cardiac function. Acid sphingomyelinase and cardiolipin metabolism can be important targets in the treatment of aging-related cardiac pathology.
      PubDate: 2017-07-01
      DOI: 10.1134/s207905701703002x
      Issue No: Vol. 7, No. 3 (2017)
       
  • Model of ontogenetic variability of the functional state of the organism
           in different regimes of motor activity
    • Authors: V. V. Myakotnyh; L. S. Khodasevich
      Pages: 201 - 207
      Abstract: Abstract This paper analyzes the results of the study of the long-term effect of physical exercising and sports in the age range, including late periods of human ontogeny, from the standpoint of the oxidative stress theory. To study the features of the ontogenetic variability of the functional state of the organism, a comparative study of the indices of the functional state of the organism was carried out under different regimes of motor activity at different age stages of development: in sport veterans who continue active motor activity after the termination of a sports career, in former sportsmen leading a sedentary lifestyle, in individuals engaged in recreational forms of exercise, and in individuals who were never regularly engaged in physical education. The contingent of male subjects of different ages also included former athletes and coaches of national teams for cyclical and game sports that require a predominant endurance. As a result of the study, a model was developed that reflects the features and mechanisms of ontogenetic variability of the functional state of the organism under the influence of different regimes of motor activity.
      PubDate: 2017-07-01
      DOI: 10.1134/s2079057017030110
      Issue No: Vol. 7, No. 3 (2017)
       
  • Emotional burnout syndrome in elderly women–physicians
    • Authors: V. S. Myakotnykh; T. A. Borovkova
      Pages: 208 - 213
      Abstract: Abstract This paper presents the results of a comparative study of the clinical symptoms of emotional burnout syndrome among 84 elderly women working in the specialty of physicians and 48 women who have officially ceased working in this specialty. The findings suggest that emotional burnout syndrome can take place in the elderly and is most closely associated with continued professional activity. The cessation of this working activity leads to stress, often with the subsequent development of posttraumatic stress disorder and stressinduced diseases. However, in this case, the clinical symptoms of emotional burnout syndrome do not disappear but are only transformed with joining of various psychosomatic disorders. Thus, the elderly who suffer from emotional burnout syndrome are a risk group as regards the formation and development of stress-associated diseases and require close attendance within the compulsory program of medical examination.
      PubDate: 2017-07-01
      DOI: 10.1134/s2079057017030109
      Issue No: Vol. 7, No. 3 (2017)
       
  • Adaptation to intermittent hypoxia-hyperoxia improves cognitive
           performance and exercise tolerance in the elderly
    • Authors: U. Bayer; O. S. Glazachev; R. Likar; M. Burtscher; W. Kofler; G. Pinter; H. Stettner; S. Demschar; B. Trummer; S. Neuwersch
      Pages: 214 - 220
      Abstract: Abstract To maintain physical performance and cognitive functions in the elderly, multimodal training programs (MTP) are used, which are based on physical training, physiotherapy procedures, psychological training, etc. To increase the efficiency of MTP in the elderly, it is suggested to apply a new variant of adaptation to interval normobaric hypoxia, interval hypoxic-hyperoxic training (IHHT). A placebo-controlled clinical trial included 34 patients aged 64–92 years of the day geriatric hospital of the Klagenfurt Clinic (Carinthia, Austria) who were randomized into two groups: experimental (EG), those who received MTP and IHHT, and control (CG), those who passed the course of MTP during the simulation of IHHT procedures. Before and after the rehabilitation course, cognitive functions and exercise endurance of the patients were evaluated using the dementia detection test DemTect, the clock-drawing test, and a 6-minute walk test (6MWT). During the course of IHHT, cognitive capabilities of EG patients significantly improved in comparison with CG patients: the increase in values in the dementia test was +16.7% (in CG +0.39%, p < 0.001), and that in the clock-drawing test was +10.7% (in CG–8%, p = 0.031). The distance covered in the 6-minute test increased in both the groups but significantly more in OG, 24.1% (in CG +10.8%, p = 0.021). Direct significant correlations between increment in exercise tolerance and cognitive tests were revealed. Thus, the inclusion of procedures for adaptation to interval hypoxia-hyperoxia in MTP in the elderly leads to a significant increase in their effectiveness, which is manifested in the improvement of cognitive functions and physical endurance. IHHT procedures are well tolerated and do not cause side effects.
      PubDate: 2017-07-01
      DOI: 10.1134/s2079057017030031
      Issue No: Vol. 7, No. 3 (2017)
       
  • Content of proinflammatory cytokines, peroxiredoxin-1, and activity of
           glutathione peroxidase in blood plasma of coronary artery disease patients
           after coronary artery bypass grafting
    • Authors: V. V. Vnukov; R. V. Sidorov; N. P. Milutina; A. A. Ananyan; D. Yu. Gvaldin; A. B. Sagakyants; I. F. Shlyk; E. P. Talalaev
      Pages: 221 - 227
      Abstract: Abstract An examination of a group of 76 CAD patients after coronary artery bypass grafting was performed with the goal to investigate the role of proinflammatory cytokines and enzymes participating in redox regulation in the mechanisms of development of systemic inflammation response and pathogenesis of postpericardiotomy syndrome (PPS). The patients were divided into two groups: the first group was CAD patients that were not diagnosed with PPS based on clinical examination, and the second group was CAD patients diagnosed with PPS. The enhancements of IL-6 and IL-8 production, as well as imbalance in the functions of peroxiredoxin-1 and glutathione peroxidase, was observed in the blood plasma of the patients from both groups. These changes were observed at earlier stages in the patients with PPS, and they were more substantial. The results of this work confirmed the high efficiency of the investigated indicators for prevention and monitoring of the PPS development.
      PubDate: 2017-07-01
      DOI: 10.1134/s2079057017030146
      Issue No: Vol. 7, No. 3 (2017)
       
  • Melatonin as a marker of severity of cardiac disorders in developing
           cachexia syndrome among cancer patients of different age groups
    • Authors: M. F. Ballyuzek; M. V. Mashkova; A. V. Arutjunyan; V. A. Duke
      Pages: 228 - 235
      Abstract: Abstract We investigated 103 newly diagnosed stage II–IV cancer patients aged 28–78 years before the beginning of their anticancer therapy. The signs of cachexia syndrome were diagnosed and staged (precachexia or fully-fledged cachexia), including the age-related characteristics of subjects, based on the CASCO criteria (2011). It has been established that cardiovascular disorders with comorbid cancer pathologies were significantly more frequently recorded in patients with signs of cachexia syndrome already at its precachexia stage, while the cumulative index of cardiovascular disorders has been found to increase in cancer patients as cachexia progressed and its severity increased. The level of melatonin excretion evaluated by the excreted amount of 6-sulfatoximelatonin (aMT6s), the mean melatonin metabolite, was observed to decrease significantly in cancer patients as the CS manifestations became more advanced. The least changes in the aMT6s levels were observed in patients aged over 60 years who were included in the precachexia group, which might indicate the heterogeneity of the given sample due to the combined manifestation of geriatric syndromes and cancer pathologies. A false-positive precachexia diagnosis is also possible, especially, in elderly and old patients, due to a combination of polygenic metabolic and age-related changes, which are to meet, in sum, the current criteria for CS. Therefore, it is recommended to determine the melatonin excretion indicator as an additional marker in the diagnosis and differential diagnosis of CS with its progression, in particular, in geriatric patients. A significant correlation has been found between the emergence of cardiac pathology and/or a worsening in its course in cancer patients with cachexia symptoms and reduced aMT6s content.
      PubDate: 2017-07-01
      DOI: 10.1134/s2079057017030043
      Issue No: Vol. 7, No. 3 (2017)
       
  • Study into ratios of mineral metabolism in patients of different age
           groups suffering from osteoarthritis of the knee
    • Authors: A. G. Gasanova; E. L. Matveeva; E. S. Spirkina
      Pages: 236 - 240
      Abstract: Abstract A study has been made into indicators of electrolyte composition and phosphatase activity of blood serum, urine, and synovial fluid of the patients belonging to different age groups and going through compensated, subcompensated, and decompensated stages of osteoarthritis of the knee. Changes in parameters of mineral metabolism have been detected related to the progress of the disease. The most obvious alteration was discovered in patients of the second age group having the subcompensated osteoarthritis stage. Elderly patients at the decompensated stage showed shifts of indicators of the bone remodeling.
      PubDate: 2017-07-01
      DOI: 10.1134/s2079057017030079
      Issue No: Vol. 7, No. 3 (2017)
       
  • Characteristics of the cognitive evoked potentials in elderly people with
           cognitive decline
    • Authors: I. N. Deryabina; Yu. S. Dzhos
      Pages: 241 - 245
      Abstract: Abstract Results of research of cognitive visual evoked potentials in elderly women with various level of cognitive decline are shown in the article. Both relevance of the early diagnostics of cognitive disorders and expedience of use of methods of functional neurovisualization to reveal higher cortical dysfunctions are also shown. To appraise cognitive functions, we applied an express-method of evaluating of cognitive functions during normal aging. According to results of this test, two groups were created: the first were women without cognitive disorders and the second were women with mild cognitive impairment. The evoked potentials were registered for all participants using a 128-channel GES-300 system. Latency of P300-wave and reaction time were calculated. According to temporary characteristics of a P300-wave, it has been revealed that the group with cognitive decline differed in longer latent period in centro-temporo-parietal area of the left hemisphere, and also longer reaction time. However, latency of P300 in central-parietal areas of the right hemisphere was less than one in persons of the control group. These changes reflect dysfunction of structures of a medial temporal lobe, which is expressed mainly by memory disorders.
      PubDate: 2017-07-01
      DOI: 10.1134/s2079057017030067
      Issue No: Vol. 7, No. 3 (2017)
       
  • Indicators of comorbidity in chronic broncho-obstructive pathology
    • Authors: F. T. Malykhin
      Pages: 246 - 251
      Abstract: Abstract We studied the issue of comorbidity in hospitalized patients with chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA, control group). A correlation and regression analysis has shown a close direct relationship between the comorbidity index and age in patients with chronic broncho-obstructive pathology. By the summary comorbidity index, patients with chronic obstructive pulmonary disease differ significantly more than two times from those of the comparison group. An increase of the comorbidity index with an increase in the severity of chronic obstructive pulmonary disease and the worsening of the forecast mortality within 3 years in COPD compared with bronchial asthma have been revealed.
      PubDate: 2017-07-01
      DOI: 10.1134/s2079057017030092
      Issue No: Vol. 7, No. 3 (2017)
       
  • Analysis of catamnesis of combatants–pensioners of the Ministry of
           Internal Affairs with mental disorders
    • Authors: A. G. Soloviev; E. G. Ichitovkina; M. V. Zlokazova
      Pages: 252 - 254
      Abstract: Abstract We analyzed catamnesis of combatants–pensioners of the Ministry of Internal Affairs (MIA) of Russia dismissed due to the presence of mental disorders impeding further serving. It is shown that, within 3 years after the dismissal, a negative clinical dynamics of mental state with disability and formation of concomitant alcohol dependence are noted among combatants. They have some serious social problems, like divorce, and they are involved in unqualified manual work or do not work at all. This requires some improved approaches in providing them with medical, psychological, and social assistance, with regular observation. It was proposed to organize Mental Health Centers in the departmental regional health units of the Ministry of Internal Affairs of Russia on the basis of existing centers of psychophysiological diagnostics for systemic monitoring of the mental state of combatants with mental disorders and improving the quality of provision of medical assistance.
      PubDate: 2017-07-01
      DOI: 10.1134/s2079057017030122
      Issue No: Vol. 7, No. 3 (2017)
       
  • Archaic stereotypes and modern approaches in understanding of aging
    • Authors: I. A. Grigoryeva; V. N. Kelasev
      Pages: 255 - 258
      Abstract: Abstract Social sciences are in the process of understanding the place of aged people in society and elaborating an adequate attitude to global aging and the elderly themselves. This appears as a conflict between the archaic stereotypes and new approaches demanded by the changed social and age structure of society. These stereotypes are characteristic not only of the elderly cohort but also of the established scientific institutions and practices. It is necessary to retarget science, media, and social policy to study and implement the potential of postponed aging.
      PubDate: 2017-07-01
      DOI: 10.1134/s2079057017030080
      Issue No: Vol. 7, No. 3 (2017)
       
  • Leukocyte telomere length as an aging marker and risk factor for human
           age-related diseases
    • Authors: V. N. Maximov; S. K. Malyutina; P. S. Orlov; D. E. Ivanoschuk; E. N. Voropaeva; M. Bobak; M. I. Voevoda
      Pages: 101 - 106
      Abstract: Abstract Leukocyte telomere length (LTL) associations with age, sex, and risk factors for age-related diseases have been studied in Russian people of preretirement and retirement age. This parameter has been determined by quantitative real-time PCR in 398 men (56.3 ± 7.2 years) and 365 women (56.6 ± 7.1 years) selected from a population sample of 45 to 69-year-old residents of the Oktyabrskii and Kirovskii raions of Novosibirsk (9400 people). The sample was formed in the course of the international project HAPIEE. Telomere length has been found to correlate with age (r =–0.159, p < 0.001) and the waist: hip ratio (WHR) (r =–0.107, p = 0.003). The average LTL in women is significantly greater than in men, p = 0.031. In men, LTL correlates with body mass (r = 0.140, p = 0.005) and waist size (r = 0.111, p = 0.027). In women, there are inverse correlations of LTL with waist size (r =–0.127, p = 0.015) and WHR (r =–0.141, p = 0.007). Leukocyte telomere length inversely correlates with the amount smoked (r =–0.121, р = 0.024). It directly correlates with age, smoking, and a variety of phenotypical traits. In men with family histories of malignancies, LTL is greater than in men without such histories.
      PubDate: 2017-04-01
      DOI: 10.1134/s2079057017020102
      Issue No: Vol. 7, No. 2 (2017)
       
  • Metabolic and hormonal indices in rats with a prolonged model of the
           metabolic syndrome induced by a high-carbohydrate and high-fat diet
    • Authors: K. V. Derkach; V. M. Bondareva; A. P. Trashkov; O. V. Chistyakova; N. A. Verlov; A. O. Shpakov
      Pages: 130 - 136
      Abstract: Abstract To develop approaches for the prevention and treatment of the metabolic syndrome (MS), a pathological state widespread in the modern population, that involves a complex of metabolic and functional disorders, appropriate animal models of the MS are required. One of these models is induced by the consumption of a combined high-carbohydrate and high-fat (HC/HF) diet. However, the character, temporal dynamics and severity of the metabolic abnormalities in MS induced by the HC/HF diet are still poorly understood. The aim of this work was to characterize the metabolic changes in Wistar rats with the MS induced by a 10- and 15-week HC/HF diet which included the consumption of a 30% sucrose solution (instead of drinking water) and food rich in saturated fats. The rats which received the HC/HF diet for 15 weeks had a number of features characteristic of the MS such as increased body mass and a specific content of abdominal fat, hyperglycemia, hyperinsulinaemia, impaired glucose tolerance, insulin resistance, dyslipidemia, as well as the markers of impaired function of the cardiovascular system, hyperhomocysteinemia, a reduced level of nitric oxide and increased concentration of endothelin-1. In the rats, which were on the diet for 10 weeks, the metabolic abnormalities were less pronounced, indicating an insufficiency of a 10-week duration of the HC/HF diet for the MS induction. Thus, the model of the MS induced by a 15-week HC/HF diet has the characteristic features which allow for extrapolation of the obtained data to similar pathologic changes in humans, and can be used in the study of the etiology and pathogenesis of the MS and in the search for effective ways of MS prevention and treatment.
      PubDate: 2017-04-01
      DOI: 10.1134/s2079057017020035
      Issue No: Vol. 7, No. 2 (2017)
       
  • The battery of tests for experimental behavioral phenotyping of aging
           animals
    • Authors: Ya. V. Gorina; Yu. K. Komleva; O. L. Lopatina; V. V. Volkova; A. I. Chernykh; A. A. Shabalova; A. A. Semenchukov; R. Ya. Olovyannikova; A. B. Salmina
      Pages: 137 - 142
      Abstract: Abstract The purpose of the study was to develop a battery of tests to study social and cognitive impairments for behavioral phenotyping of aged experimental animals with physiological neurodegeneration. Male outbred CD1 mice used for the study were divided into two groups: group 1 consisted of 12-month-old male mice (physiological aging) and group 2 consisted of 2-month-old male mice (control group). A social recognition 5-trial test, elevated plus maze test (EPM), open field test, light-dark box test, and fear conditioning were used for estimation of the neurological state of experimental animals. We found that aged male mice exhibited lower interest in female mice in the social 5-trial task as compared to young male mice. Increased anxiety was observed in the group of aging mice in the EPM and light-dark box tests as compared to the control group. Lower locomotor activity and increased anxiety were found in the aging rats studied in the open field test. Physiological neurodegeneration was related to impaired associative learning and memory in the group of aging mice, which were observed in fear conditioning; particularly, consolidation of fear memory was dramatically suppressed. Analysis of behavioral factors, social interactions, and anxiety confirmed a model of agerelated neurodegeneration in the aged mice. We suggest that studies on animal behavior in the open field test, light-dark box test, and fear conditioning is the most informative approach for detection of neurological impairments, including deficits of social contacts and interaction, limitation of interests, and increased anxiety, in aging mice. This allows us to get new basic data on behavioral alterations in a model of age-related neurodegeneration and to develop novel therapeutic strategies for the treatment of age-related brain pathology.
      PubDate: 2017-04-01
      DOI: 10.1134/s2079057017020060
      Issue No: Vol. 7, No. 2 (2017)
       
  • Age-related peculiarities of cytogenetic consequences of spring–summer
           tick-borne encephalitis among residents of northwestern Siberia due to
           polymorphism of glutathione S -transferase genes
    • Authors: N. N. Ilyinskikh; E. N. Ilyinskikh
      Pages: 155 - 157
      Abstract: Abstract The aim of the present work was a comparative study of cytogenetic consequences of spring–summer tick-borne encephalitis in elderly and young individuals due to differences in glutathione S-transferase genes. The cytogenetic survey was conducted in 120 tick-borne encephalitis patients, residents of the north of Tomsk oblast (20–35 years (1st group) and 65–85 years (2nd group)). A material for the study (buccal epithelium) was taken in each subject 3–5 times: 1st–2nd day after hospitalization, in 1 week, 1, 3, 6 months. It was established that tick-borne encephalitis causes significantly larger cytogenetic changes in the buccal epithelium in elderly than in young patients. The recovery of the cytogenetic norm is observed in the group of young individuals three months after hospitalization; elderly individuals, six months after. When comparing cytogenetic consequences of tick-borne encephalitis, it was demonstrated that in young patients the level of cytogenetically anomalous cells was significantly higher in carriers of inactive GSTM1(0)/GSTT1(0) gene forms as compared with patients in which homozygous variants of these genes were active. No such dependence was registered in elderly patients.
      PubDate: 2017-04-01
      DOI: 10.1134/s2079057017020084
      Issue No: Vol. 7, No. 2 (2017)
       
  • Compensatory rearrangements in the cortical control of movement in elderly
           patients with chronic cerebral ischemia
    • Authors: E. A. Dubinina; Yu. G. Novikova
      Pages: 158 - 162
      Abstract: Abstract Dynamic praxis was tested in three groups of elderly subjects, including control respondents with mild cognitive impairment, respondents with moderate cognitive impairment, and patients with vascular dementia. The groups were compared with one another. This comparison was methodologically based on Luria’s theory of systemic and dynamic localization of higher mental functions. The elderly subjects manifested disorders in praxis. Locomotor actions become slow in elderly subjects with mild cognitive impairment. These subjects compensated for difficulties in mastering a dynamic program by verbalizing this program and delaying the orientation phase of the action. Respondents with moderate cognitive impairment and clear manifestations of cerebrovascular pathology had stereotypies in the motor sphere and a speed slowdown in motor actions, which were more expressed in patients with vascular dementia. These subjects could only in part compensate for these disorders. But some of them could master a motor program after a cue or education.
      PubDate: 2017-04-01
      DOI: 10.1134/s2079057017020047
      Issue No: Vol. 7, No. 2 (2017)
       
  • The use of speech audiometry in the practice of the geriatric center
    • Authors: M. Yu. Boboshko; E. V. Zhilinskaia; L. E. Golovanova; T. V. Legostaeva; F. Di Berardino; A. Cesarani
      Pages: 166 - 169
      Abstract: Abstract The aim of the study was to evaluate a new test of speech audiometry while examining aged patients. Thirty-two aged listeners from 60 to 88 years old were examined: 20 hearing aid (HA) users and 12 patients with normal hearing thresholds and mild cognitive impairment according to the results of the minimental state examination (MMSE). The speech audiometry consisted of the traditional polysyllabic word discrimination test and a new speech test with motor responses (Verbal Tasks and Motor Responses—VTMR); in both tests the speech signal was presented in background noise (polyphony) in free field. All listeners performed the VTMR test significantly better than the polysyllabic word discrimination test. In the group of hearingimpaired patients the mean result in the VTMR test was 73.2 ± 29.2% without a HA and 88.6 ± 20.5% with it; in the traditional test, 34.8 ± 20.9% without a HA and 56.0 ± 18.4% with it. All patients of the group with normal hearing and mild cognitive impairment performed the VTMR test with a 100% result, their speech discrimination score in traditional test was 88.0 ± 12.0%. In the practice of the geriatric center the use of both traditional speech audiometry and the new speech test with motor responses seems to be reasonable. It allows examining the auditory function in patients with significant deterioration of speech intelligibility or cognitive impairment.
      PubDate: 2017-04-01
      DOI: 10.1134/s2079057017020023
      Issue No: Vol. 7, No. 2 (2017)
       
  • Recovery of the shape of vertebral bodies under transpedicular fixation in
           osteoporotic vertebral fractures
    • Authors: V. V. Rerikh; S. M. Gudi; M. U. Baidarbekov; K. A. Anikin
      Pages: 170 - 175
      Abstract: Abstract The parameters of posttraumatic deformity correction in 27 patients aged from 61 to 76 (62.9 ± 1.4) years were analyzed using osteoplasty and transpedicular fixation for osteoporotic thoracolumbar fractures of vertebral bodies. Indicators of posttraumatic deformity, the wedging index (WI) and segmental kyphosis (SK), decreased in all patients. At the same time, minimally invasive (transcutaneous) surgery made it possible to restore the lost anatomy without being inferior to the results of open intervention. In patients with compression fractures both the WI and SK decreased significantly; in patients with a burst nature of injury only WI became lower. In patients with the T-test > –3 SD both the deformation indicators decreased, and with a more pronounced decrease in mineral density (T-test < –3) only WI decreased significantly. The results indicate recovery of lost anatomy, but the degree of correction depends on the nature of the fracture and the amount of bone mass.
      PubDate: 2017-04-01
      DOI: 10.1134/s207905701702014x
      Issue No: Vol. 7, No. 2 (2017)
       
 
 
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