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Publisher: Springer-Verlag (Total: 2352 journals)

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Showing 1 - 200 of 2352 Journals sorted alphabetically
3D Printing in Medicine     Open Access   (Followers: 2)
3D Research     Hybrid Journal   (Followers: 21, SJR: 0.222, CiteScore: 1)
4OR: A Quarterly J. of Operations Research     Hybrid Journal   (Followers: 10, SJR: 0.825, CiteScore: 1)
AAPS J.     Hybrid Journal   (Followers: 23, SJR: 1.118, CiteScore: 4)
AAPS PharmSciTech     Hybrid Journal   (Followers: 7, SJR: 0.752, CiteScore: 3)
Abdominal Imaging     Hybrid Journal   (Followers: 16, SJR: 0.866, CiteScore: 2)
Abhandlungen aus dem Mathematischen Seminar der Universitat Hamburg     Hybrid Journal   (Followers: 4, SJR: 0.439, CiteScore: 0)
Academic Psychiatry     Full-text available via subscription   (Followers: 26, SJR: 0.53, CiteScore: 1)
Academic Questions     Hybrid Journal   (Followers: 8, SJR: 0.106, CiteScore: 0)
Accreditation and Quality Assurance: J. for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 29, SJR: 0.316, CiteScore: 1)
Acoustical Physics     Hybrid Journal   (Followers: 11, SJR: 0.359, CiteScore: 1)
Acoustics Australia     Hybrid Journal   (SJR: 0.232, CiteScore: 1)
Acta Analytica     Hybrid Journal   (Followers: 7, SJR: 0.367, CiteScore: 0)
Acta Applicandae Mathematicae     Hybrid Journal   (Followers: 1, SJR: 0.675, CiteScore: 1)
Acta Biotheoretica     Hybrid Journal   (Followers: 4, SJR: 0.284, CiteScore: 1)
Acta Diabetologica     Hybrid Journal   (Followers: 19, SJR: 1.587, CiteScore: 3)
Acta Endoscopica     Hybrid Journal   (Followers: 1)
acta ethologica     Hybrid Journal   (Followers: 4, SJR: 0.769, CiteScore: 1)
Acta Geochimica     Hybrid Journal   (Followers: 7, SJR: 0.24, CiteScore: 1)
Acta Geodaetica et Geophysica     Hybrid Journal   (Followers: 3, SJR: 0.305, CiteScore: 1)
Acta Geophysica     Hybrid Journal   (Followers: 11, SJR: 0.312, CiteScore: 1)
Acta Geotechnica     Hybrid Journal   (Followers: 7, SJR: 1.588, CiteScore: 3)
Acta Informatica     Hybrid Journal   (Followers: 5, SJR: 0.517, CiteScore: 1)
Acta Mathematica     Hybrid Journal   (Followers: 13, SJR: 7.066, CiteScore: 3)
Acta Mathematica Hungarica     Hybrid Journal   (Followers: 2, SJR: 0.452, CiteScore: 1)
Acta Mathematica Sinica, English Series     Hybrid Journal   (Followers: 6, SJR: 0.379, CiteScore: 1)
Acta Mathematica Vietnamica     Hybrid Journal   (SJR: 0.27, CiteScore: 0)
Acta Mathematicae Applicatae Sinica, English Series     Hybrid Journal   (SJR: 0.208, CiteScore: 0)
Acta Mechanica     Hybrid Journal   (Followers: 21, SJR: 1.04, CiteScore: 2)
Acta Mechanica Sinica     Hybrid Journal   (Followers: 5, SJR: 0.607, CiteScore: 2)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 7, SJR: 0.576, CiteScore: 2)
Acta Meteorologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.638, CiteScore: 1)
Acta Neurochirurgica     Hybrid Journal   (Followers: 7, SJR: 0.822, CiteScore: 2)
Acta Neurologica Belgica     Hybrid Journal   (Followers: 1, SJR: 0.376, CiteScore: 1)
Acta Neuropathologica     Hybrid Journal   (Followers: 4, SJR: 7.589, CiteScore: 12)
Acta Oceanologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.334, CiteScore: 1)
Acta Physiologiae Plantarum     Hybrid Journal   (Followers: 3, SJR: 0.574, CiteScore: 2)
Acta Politica     Hybrid Journal   (Followers: 15, SJR: 0.605, CiteScore: 1)
Activitas Nervosa Superior     Hybrid Journal   (SJR: 0.147, CiteScore: 0)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 8, SJR: 0.103, CiteScore: 0)
ADHD Attention Deficit and Hyperactivity Disorders     Hybrid Journal   (Followers: 25, SJR: 0.72, CiteScore: 2)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 9)
Administration and Policy in Mental Health and Mental Health Services Research     Partially Free   (Followers: 17, SJR: 1.005, CiteScore: 2)
Adsorption     Hybrid Journal   (Followers: 4, SJR: 0.703, CiteScore: 2)
Advances in Applied Clifford Algebras     Hybrid Journal   (Followers: 4, SJR: 0.698, CiteScore: 1)
Advances in Atmospheric Sciences     Hybrid Journal   (Followers: 37, SJR: 0.956, CiteScore: 2)
Advances in Computational Mathematics     Hybrid Journal   (Followers: 19, SJR: 0.812, CiteScore: 1)
Advances in Contraception     Hybrid Journal   (Followers: 3)
Advances in Data Analysis and Classification     Hybrid Journal   (Followers: 59, SJR: 1.09, CiteScore: 1)
Advances in Gerontology     Partially Free   (Followers: 8, SJR: 0.144, CiteScore: 0)
Advances in Health Sciences Education     Hybrid Journal   (Followers: 30, SJR: 1.64, CiteScore: 2)
Advances in Manufacturing     Hybrid Journal   (Followers: 4, SJR: 0.475, CiteScore: 2)
Advances in Polymer Science     Hybrid Journal   (Followers: 45, SJR: 1.04, CiteScore: 3)
Advances in Therapy     Hybrid Journal   (Followers: 5, SJR: 1.075, CiteScore: 3)
Aegean Review of the Law of the Sea and Maritime Law     Hybrid Journal   (Followers: 6)
Aequationes Mathematicae     Hybrid Journal   (Followers: 2, SJR: 0.517, CiteScore: 1)
Aerobiologia     Hybrid Journal   (Followers: 3, SJR: 0.673, CiteScore: 2)
Aesthetic Plastic Surgery     Hybrid Journal   (Followers: 11, SJR: 0.825, CiteScore: 1)
African Archaeological Review     Hybrid Journal   (Followers: 20, SJR: 0.862, CiteScore: 1)
Afrika Matematika     Hybrid Journal   (Followers: 1, SJR: 0.235, CiteScore: 0)
AGE     Hybrid Journal   (Followers: 7)
Ageing Intl.     Hybrid Journal   (Followers: 7, SJR: 0.39, CiteScore: 1)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
Aging Clinical and Experimental Research     Hybrid Journal   (Followers: 3, SJR: 0.67, CiteScore: 2)
Agricultural Research     Hybrid Journal   (Followers: 6, SJR: 0.276, CiteScore: 1)
Agriculture and Human Values     Hybrid Journal   (Followers: 14, SJR: 1.173, CiteScore: 3)
Agroforestry Systems     Hybrid Journal   (Followers: 20, SJR: 0.663, CiteScore: 1)
Agronomy for Sustainable Development     Hybrid Journal   (Followers: 13, SJR: 1.864, CiteScore: 6)
AI & Society     Hybrid Journal   (Followers: 9, SJR: 0.227, CiteScore: 1)
AIDS and Behavior     Hybrid Journal   (Followers: 14, SJR: 1.792, CiteScore: 3)
Air Quality, Atmosphere & Health     Hybrid Journal   (Followers: 4, SJR: 0.862, CiteScore: 3)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Algebra and Logic     Hybrid Journal   (Followers: 6, SJR: 0.531, CiteScore: 0)
Algebra Universalis     Hybrid Journal   (Followers: 2, SJR: 0.583, CiteScore: 1)
Algebras and Representation Theory     Hybrid Journal   (Followers: 1, SJR: 1.095, CiteScore: 1)
Algorithmica     Hybrid Journal   (Followers: 9, SJR: 0.56, CiteScore: 1)
Allergo J.     Full-text available via subscription   (Followers: 1, SJR: 0.234, CiteScore: 0)
Allergo J. Intl.     Hybrid Journal   (Followers: 2)
Alpine Botany     Hybrid Journal   (Followers: 5, SJR: 1.11, CiteScore: 3)
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 3)
AMBIO     Hybrid Journal   (Followers: 10, SJR: 1.569, CiteScore: 4)
American J. of Cardiovascular Drugs     Hybrid Journal   (Followers: 16, SJR: 0.951, CiteScore: 3)
American J. of Community Psychology     Hybrid Journal   (Followers: 29, SJR: 1.329, CiteScore: 2)
American J. of Criminal Justice     Hybrid Journal   (Followers: 9, SJR: 0.772, CiteScore: 1)
American J. of Cultural Sociology     Hybrid Journal   (Followers: 17, SJR: 0.46, CiteScore: 1)
American J. of Dance Therapy     Hybrid Journal   (Followers: 4, SJR: 0.181, CiteScore: 0)
American J. of Potato Research     Hybrid Journal   (Followers: 2, SJR: 0.611, CiteScore: 1)
American J. of Psychoanalysis     Hybrid Journal   (Followers: 21, SJR: 0.314, CiteScore: 0)
American Sociologist     Hybrid Journal   (Followers: 14, SJR: 0.35, CiteScore: 0)
Amino Acids     Hybrid Journal   (Followers: 8, SJR: 1.135, CiteScore: 3)
AMS Review     Partially Free   (Followers: 4)
Analog Integrated Circuits and Signal Processing     Hybrid Journal   (Followers: 7, SJR: 0.211, CiteScore: 1)
Analysis and Mathematical Physics     Hybrid Journal   (Followers: 5, SJR: 0.536, CiteScore: 1)
Analysis in Theory and Applications     Hybrid Journal   (Followers: 1)
Analysis of Verbal Behavior     Hybrid Journal   (Followers: 6)
Analytical and Bioanalytical Chemistry     Hybrid Journal   (Followers: 32, SJR: 0.978, CiteScore: 3)
Anatomical Science Intl.     Hybrid Journal   (Followers: 3, SJR: 0.367, CiteScore: 1)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3, SJR: 2.177, CiteScore: 5)
Animal Cognition     Hybrid Journal   (Followers: 20, SJR: 1.389, CiteScore: 3)
Annales françaises de médecine d'urgence     Hybrid Journal   (Followers: 1, SJR: 0.192, CiteScore: 0)
Annales Henri Poincaré     Hybrid Journal   (Followers: 3, SJR: 1.097, CiteScore: 2)
Annales mathématiques du Québec     Hybrid Journal   (Followers: 4, SJR: 0.438, CiteScore: 0)
Annali dell'Universita di Ferrara     Hybrid Journal   (SJR: 0.429, CiteScore: 0)
Annali di Matematica Pura ed Applicata     Hybrid Journal   (Followers: 1, SJR: 1.197, CiteScore: 1)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 17, SJR: 1.042, CiteScore: 3)
Annals of Combinatorics     Hybrid Journal   (Followers: 4, SJR: 0.932, CiteScore: 1)
Annals of Data Science     Hybrid Journal   (Followers: 12)
Annals of Dyslexia     Hybrid Journal   (Followers: 10, SJR: 0.85, CiteScore: 2)
Annals of Finance     Hybrid Journal   (Followers: 31, SJR: 0.579, CiteScore: 1)
Annals of Forest Science     Hybrid Journal   (Followers: 7, SJR: 0.986, CiteScore: 2)
Annals of Global Analysis and Geometry     Hybrid Journal   (Followers: 1, SJR: 1.228, CiteScore: 1)
Annals of Hematology     Hybrid Journal   (Followers: 15, SJR: 1.043, CiteScore: 2)
Annals of Mathematics and Artificial Intelligence     Hybrid Journal   (Followers: 12, SJR: 0.413, CiteScore: 1)
Annals of Microbiology     Hybrid Journal   (Followers: 11, SJR: 0.479, CiteScore: 2)
Annals of Nuclear Medicine     Hybrid Journal   (Followers: 4, SJR: 0.687, CiteScore: 2)
Annals of Operations Research     Hybrid Journal   (Followers: 10, SJR: 0.943, CiteScore: 2)
Annals of Ophthalmology     Hybrid Journal   (Followers: 12)
Annals of Regional Science     Hybrid Journal   (Followers: 8, SJR: 0.614, CiteScore: 1)
Annals of Software Engineering     Hybrid Journal   (Followers: 13)
Annals of Solid and Structural Mechanics     Hybrid Journal   (Followers: 9, SJR: 0.239, CiteScore: 1)
Annals of Surgical Oncology     Hybrid Journal   (Followers: 15, SJR: 1.986, CiteScore: 4)
Annals of Telecommunications     Hybrid Journal   (Followers: 9, SJR: 0.223, CiteScore: 1)
Annals of the Institute of Statistical Mathematics     Hybrid Journal   (Followers: 1, SJR: 1.495, CiteScore: 1)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 5, SJR: 0.834, CiteScore: 2)
Apidologie     Hybrid Journal   (Followers: 4, SJR: 1.22, CiteScore: 3)
APOPTOSIS     Hybrid Journal   (Followers: 9, SJR: 1.424, CiteScore: 4)
Applicable Algebra in Engineering, Communication and Computing     Hybrid Journal   (Followers: 2, SJR: 0.294, CiteScore: 1)
Applications of Mathematics     Hybrid Journal   (Followers: 2, SJR: 0.602, CiteScore: 1)
Applied Biochemistry and Biotechnology     Hybrid Journal   (Followers: 44, SJR: 0.571, CiteScore: 2)
Applied Biochemistry and Microbiology     Hybrid Journal   (Followers: 18, SJR: 0.21, CiteScore: 1)
Applied Categorical Structures     Hybrid Journal   (Followers: 5, SJR: 0.49, CiteScore: 0)
Applied Composite Materials     Hybrid Journal   (Followers: 49, SJR: 0.58, CiteScore: 2)
Applied Entomology and Zoology     Partially Free   (Followers: 6, SJR: 0.422, CiteScore: 1)
Applied Geomatics     Hybrid Journal   (Followers: 3, SJR: 0.733, CiteScore: 3)
Applied Geophysics     Hybrid Journal   (Followers: 8, SJR: 0.488, CiteScore: 1)
Applied Intelligence     Hybrid Journal   (Followers: 13, SJR: 0.6, CiteScore: 2)
Applied Magnetic Resonance     Hybrid Journal   (Followers: 4, SJR: 0.319, CiteScore: 1)
Applied Mathematics & Optimization     Hybrid Journal   (Followers: 8, SJR: 0.886, CiteScore: 1)
Applied Mathematics - A J. of Chinese Universities     Hybrid Journal   (SJR: 0.17, CiteScore: 0)
Applied Mathematics and Mechanics     Hybrid Journal   (Followers: 5, SJR: 0.461, CiteScore: 1)
Applied Microbiology and Biotechnology     Hybrid Journal   (Followers: 66, SJR: 1.182, CiteScore: 4)
Applied Physics A     Hybrid Journal   (Followers: 10, SJR: 0.481, CiteScore: 2)
Applied Physics B: Lasers and Optics     Hybrid Journal   (Followers: 24, SJR: 0.74, CiteScore: 2)
Applied Psychophysiology and Biofeedback     Hybrid Journal   (Followers: 8, SJR: 0.519, CiteScore: 2)
Applied Research in Quality of Life     Hybrid Journal   (Followers: 12, SJR: 0.316, CiteScore: 1)
Applied Solar Energy     Hybrid Journal   (Followers: 21, SJR: 0.225, CiteScore: 0)
Applied Spatial Analysis and Policy     Hybrid Journal   (Followers: 7, SJR: 0.542, CiteScore: 1)
Aquaculture Intl.     Hybrid Journal   (Followers: 26, SJR: 0.591, CiteScore: 2)
Aquarium Sciences and Conservation     Hybrid Journal   (Followers: 2)
Aquatic Ecology     Hybrid Journal   (Followers: 36, SJR: 0.656, CiteScore: 2)
Aquatic Geochemistry     Hybrid Journal   (Followers: 4, SJR: 0.591, CiteScore: 1)
Aquatic Sciences     Hybrid Journal   (Followers: 13, SJR: 1.109, CiteScore: 3)
Arabian J. for Science and Engineering     Hybrid Journal   (Followers: 5, SJR: 0.303, CiteScore: 1)
Arabian J. of Geosciences     Hybrid Journal   (Followers: 2, SJR: 0.319, CiteScore: 1)
Archaeological and Anthropological Sciences     Hybrid Journal   (Followers: 21, SJR: 1.052, CiteScore: 2)
Archaeologies     Hybrid Journal   (Followers: 12, SJR: 0.224, CiteScore: 0)
Archiv der Mathematik     Hybrid Journal   (Followers: 1, SJR: 0.725, CiteScore: 1)
Archival Science     Hybrid Journal   (Followers: 63, SJR: 0.745, CiteScore: 2)
Archive for History of Exact Sciences     Hybrid Journal   (Followers: 7, SJR: 0.186, CiteScore: 1)
Archive for Mathematical Logic     Hybrid Journal   (Followers: 3, SJR: 0.909, CiteScore: 1)
Archive for Rational Mechanics and Analysis     Hybrid Journal   (SJR: 3.93, CiteScore: 3)
Archive of Applied Mechanics     Hybrid Journal   (Followers: 6, SJR: 0.79, CiteScore: 2)
Archives and Museum Informatics     Hybrid Journal   (Followers: 152, SJR: 0.101, CiteScore: 0)
Archives of Computational Methods in Engineering     Hybrid Journal   (Followers: 6, SJR: 1.41, CiteScore: 5)
Archives of Dermatological Research     Hybrid Journal   (Followers: 7, SJR: 1.006, CiteScore: 2)
Archives of Environmental Contamination and Toxicology     Hybrid Journal   (Followers: 14, SJR: 0.773, CiteScore: 2)
Archives of Gynecology and Obstetrics     Hybrid Journal   (Followers: 17, SJR: 0.956, CiteScore: 2)
Archives of Microbiology     Hybrid Journal   (Followers: 9, SJR: 0.644, CiteScore: 2)
Archives of Orthopaedic and Trauma Surgery     Hybrid Journal   (Followers: 9, SJR: 1.146, CiteScore: 2)
Archives of Osteoporosis     Hybrid Journal   (Followers: 2, SJR: 0.71, CiteScore: 2)
Archives of Sexual Behavior     Hybrid Journal   (Followers: 10, SJR: 1.493, CiteScore: 3)
Archives of Toxicology     Hybrid Journal   (Followers: 17, SJR: 1.541, CiteScore: 5)
Archives of Virology     Hybrid Journal   (Followers: 5, SJR: 0.973, CiteScore: 2)
Archives of Women's Mental Health     Hybrid Journal   (Followers: 15, SJR: 1.274, CiteScore: 3)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2, SJR: 0.946, CiteScore: 3)
ArgoSpine News & J.     Hybrid Journal  
Argumentation     Hybrid Journal   (Followers: 6, SJR: 0.349, CiteScore: 1)
Arid Ecosystems     Hybrid Journal   (Followers: 2, SJR: 0.2, CiteScore: 0)
Arkiv för Matematik     Hybrid Journal   (Followers: 2, SJR: 0.766, CiteScore: 1)
Arnold Mathematical J.     Hybrid Journal   (Followers: 1, SJR: 0.355, CiteScore: 0)
Arthropod-Plant Interactions     Hybrid Journal   (Followers: 2, SJR: 0.839, CiteScore: 2)
Arthroskopie     Hybrid Journal   (Followers: 1, SJR: 0.131, CiteScore: 0)
Artificial Intelligence and Law     Hybrid Journal   (Followers: 11, SJR: 0.937, CiteScore: 2)
Artificial Intelligence Review     Hybrid Journal   (Followers: 18, SJR: 0.833, CiteScore: 4)
Artificial Life and Robotics     Hybrid Journal   (Followers: 9, SJR: 0.226, CiteScore: 0)
Asia Europe J.     Hybrid Journal   (Followers: 5, SJR: 0.504, CiteScore: 1)
Asia Pacific Education Review     Hybrid Journal   (Followers: 12, SJR: 0.479, CiteScore: 1)
Asia Pacific J. of Management     Hybrid Journal   (Followers: 16, SJR: 1.185, CiteScore: 2)
Asia-Pacific Education Researcher     Hybrid Journal   (Followers: 13, SJR: 0.353, CiteScore: 1)
Asia-Pacific Financial Markets     Hybrid Journal   (Followers: 2, SJR: 0.187, CiteScore: 0)
Asia-Pacific J. of Atmospheric Sciences     Hybrid Journal   (Followers: 19, SJR: 0.855, CiteScore: 1)
Asian Business & Management     Hybrid Journal   (Followers: 9, SJR: 0.378, CiteScore: 1)
Asian J. of Business Ethics     Hybrid Journal   (Followers: 10)
Asian J. of Criminology     Hybrid Journal   (Followers: 6, SJR: 0.543, CiteScore: 1)
AStA Advances in Statistical Analysis     Hybrid Journal   (Followers: 5, SJR: 0.548, CiteScore: 1)
AStA Wirtschafts- und Sozialstatistisches Archiv     Hybrid Journal   (Followers: 5, SJR: 0.183, CiteScore: 0)
ästhetische dermatologie & kosmetologie     Full-text available via subscription  
Astronomy and Astrophysics Review     Hybrid Journal   (Followers: 22, SJR: 3.385, CiteScore: 5)

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Journal Cover
Advances in Gerontology
Journal Prestige (SJR): 0.144
Number of Followers: 8  
  Partially Free Journal Partially Free Journal
ISSN (Print) 2079-0570 - ISSN (Online) 2079-0589
Published by Springer-Verlag Homepage  [2352 journals]
  • Attitudes towards Aging Prevention: Results of a Focus-Group Study
    • Abstract: Emerging life-extension technologies and generally used therapies aimed at preventing agingrelated pathological processes have significant potential to alleviate the burden of disease in an aging world. However, promoting these technologies requires research of public opinion with the use of marketing techniques. We studied social attitudes toward life-extension technologies and use of geroprotective medicines by conducting three focus groups. The total sample included 18 people with university degrees 25–70 years of age who were living in Moscow (Russia). The tested statements were obtained in advance by surveying 30 experts in gerontology. The focus group participants were most in agreement with the statement that “aging prevention will help to maintain health and increase the active period of life.” Despite the doubts of experts, the idea that aging is a disease convinces a considerable share of the informants when the scientific evidence of the connection between aging processes and aging-related health damage is provided. Introducing new agendas into the discussion (pensions, overpopulation, etc.) turned out to be counterproductive due to new counterarguments emerging in the group discussions. The idea of radical life extension (200 years and more) was perceived skeptically. Some skepticism was attributed to mistrust and disappointment in the modern healthcare system in general. Gene therapies were perceived with caution. The word “geroprotector” is not well known even to the educated general public.
      PubDate: 2018-01-01
      DOI: 10.1134/S2079057018010125
  • The Effect of Light Deprivation and Luzindole on the Ovulatory Function in
    • Abstract: We studied age-related changes in the ovulatory function in rats subjected to light deprivation and treated with the blocker of the melatonin receptors Luzindol. A cytological study of the estrus cycle was performed quarterly for 2 years. We found that, under conditions of light deprivation, age-related changes in the ovulatory cycle appeared later on and were less expressed than those observed in control females housed under standard light conditions. Blocking of the melatonin receptors with Luzindol did not significantly modified time course of aging as compared to the control group housed under standard lighting.
      PubDate: 2018-01-01
      DOI: 10.1134/S2079057018010095
  • Gender-Specific Manifestations of Daily Physical Activity and Sedentary
           Behavior in Elderly Residents of Surgut
    • Abstract: The objective of the study was to establish gender-specific characteristics of physical activity (PA) and sedentary behavior in elderly inhabitants of North Yugra. Two hundred and ninety-five residents of Surgut (102 men aged 62.9 ± 5.3 years, 35%; 193 women aged 61.9 ± 3.8 years, 65%) completed a IPAQ-RU questionnaire. The study revealed gender-specific differences in body length and mass, as well as in the bodymass and body-fat indices. It was found that more energy was spent on physical activity in work in the home or summer home (moderate-intensity physical activity for women and high-intensity for men). The data of the study showed no statistically significant gender-specific differences in general physical activity. Sedentary behavior is more common among men than women (2543 vs. 2441 min/week). An amount of 47% of lowactivity men and 56% of women reported that they spent 6–9 h/day sitting, while 42% reported 9–12 h/day. Special measures should be taken to increase physical activity, which is too low at the moment, and to decrease sedentary behavior, which is currently at a high level.
      PubDate: 2018-01-01
      DOI: 10.1134/S2079057018010058
  • Age-Related Dynamics of Cognitive Functions in Persons Aged 50–85
    • Abstract: This paper presents the results of an original study devoted to the dynamics of cognitive functions in the population cohort 50 to 85 years of age without neurodegenerative, vascular, or other significant diseases associated with cognitive impairment. It has been shown that memory moderately declines with aging, which is expressed in inadequacy of recollection against a relatively preserved level of memory, and mild executive dysfunctions develop (in planning and control). According to the generally accepted neuropsychological approaches, these age-related cognitive changes emerge due to anterior cortical dysfunctions and/or impaired interaction between the frontal lobes and subcortical basal ganglia. This study has also shown that there are types of age-related physiological changes normally occurring in the area of memory and executive functions, which is clinically important for differential diagnosis to distinguish normal aging from the early stages of cerebral diseases typical of the elderly.
      PubDate: 2018-01-01
      DOI: 10.1134/S2079057018010137
  • The Cognitive Cytokine Effect of Nonsteroidal Antiinflammatory Drugs in
           the Treatment of Elderly Patients with Osteoarthritis
    • Abstract: The goal of this study was to evaluate the effect of long-term nonsteroidal antiinflammatory drug (NSAID) therapy on the severity of cognitive deficiency in elderly patients with osteoarthritis (OA) and the relationship between this effect and cytokine fluctuations in the blood serum of the patients. This prospective observational study took 540 ± 5.5 days and was conducted in two stages: phase I consisted of active medication therapy based on NSAIDs, and phase II was connected with nonpharmacological OA management. A cohort of 128 OA patients aged 65–75 years (the mean age was 70 ± 4.6 years, 10.2% men and 89.8% women) participated in the study. Patients from the main group were divided into four subgroups: the first group (n = 30) received etoricoxib at a daily dose of 60 mg, the second group (n = 32) took celecoxib at a daily dose of 200 mg, the third group (n = 32) was given a daily 100-mg dose of nimesulid, and the patients of the fourth group (n = 34) took meloxicam at a daily dose of 7.5 mg. The control group was formed of 40 patients with OA having analogous clinical and demographic characteristics and not taking NSAIDs in the previous six months and in the course of the study. The initial stiffness and pain indices were measured in all patients by the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) subscales, while their condition was evaluated during all visits to the clinic by the Montreal Cognitive Assessment (MoCA) Scale along with laboratory investigations for the blood serum contents of Transforming Growth Factor (TGF)-β1, Interleukin (IL)-1β, and IL-6. Statistically significant decreases in the levels of cytokines were recorded in the period from the first to the third visits in all patients of the main group, as were increases in the indices of cognitive functions by the MoCA scale with a high degree of correlation relative to the cytokine indicators were observed by the end of the study. The results of the study have allowed us to suggest that the NSAID therapy may have an effect on the cognitive functions of elderly patients with OA in real clinical practice.
      PubDate: 2018-01-01
      DOI: 10.1134/S2079057018010149
  • A New Stage of Development of Gerontology and Geriatrics in Russia:
           Problems in Creation of a Geriatric-Care System. Part 2. Structure of the
           System and a Scientific Approach
    • Abstract: This publication is the second part of an analytical review of a new stage of development of gerontology and geriatrics in Russia. The components of a social-support system for senior citizens and the structure of social and medical support as its crucial components are presented. The problem of positioning the geriatric care within the system of social support for senior citizens, as well as its peculiarities and an algorithm for providing geriatric care, are discussed. The analysis of this algorithm allowed us to confirm that there is an indissoluble link between and a continuity of individual components of geriatric care and its cost effectiveness. The position of the Russian Federation Ministry of Health concerning the introduction of geriatric care as an element in the system of medical care for older citizens is shown. The “Territory of Care” pilot project proposed by the Russian Federation Ministry of Labor and Ministry of Health for establishing a long-term system of medical and social care for citizens of the older generation based on the principles of multidisciplinary and interdepartmental interaction is presented as well. Some flaws of the project are highlighted, and recommendations for its improvement are given. The role of gerontology as a systemic basis for providing geriatric service in Russia and developing an integrated system of social and medical care for citizens of the older generation is underlined. The main priorities in the field of aging in the forthcoming decade are formulated. The most promising areas of research in the field of gerontology are discussed, the implementation of which will allow implementing state social-policy goals focused on the quality of life of senior citizens. Finally, the position of the Gerontological Society of the Russian Academy of Sciences regarding the creation of mechanisms of scientific supervision for the renovation of geriatric services, including collaboration with experts in the field of practical medicine and social workers, and organization of scientific coordination of all work performed for the development of geriatric care for the citizens of older generation are presented.
      PubDate: 2018-01-01
      DOI: 10.1134/S2079057018010022
  • Epidemiological, Clinical, and Pathogenic Features of Stroke at Elderly
           and Very Elderly Age
    • Abstract: A comparative investigation of the epidemiological, clinical, and pathogenetic indices of cerebral stroke in 1153 representatives of different age has been conducted. The prevalence of the incidence of strokes among women of elderly and very elderly age is largely due to the higher life expectancy of women compared to men. A significant number of intracerebral blood effusions in elderly and very elderly age can arise secondarily after ischemic focus formation of the type of “red softening.” This, to a certain extent, can be explained by the high frequency of somatic complications of stroke, disorders of consciousness, and high mortality among persons older than 60 years compared to younger people. Less positive clinical outcomes of stroke at elderly and very elderly age, even when increasing the length of their hospital stay, may indicate shortcomings in the existing standards of diagnostics and treatment in people with a combination of background pathologies in stroke completely different from that of the young individuals.
      PubDate: 2018-01-01
      DOI: 10.1134/S2079057018010101
  • Is It Possible to Rejuvenate the Aging Global Civilization'
    • Abstract: Society is not only a social, but also a biological, system. The growing complexity of biological systems inevitably leads to the loss of their potential immortality and to the emergence of the aging. The aging of the present-day civilization is evidenced by the problems that have accumulated in it. The question of whether its collapse can be stopped depends on the answer to a more general question of whether this supraorganismal system, which, due to growth of structural complexity, has acquired the property of aging, can, without losing the complexity that has been achieved, return to its ancestral potential immortality. A positive response is given to this question. There are supraorganismal systems that have been liberated from the necessity of aging. These are communities of social insects. Some of them were initially moral, but, in the course of evolution, have lost the aging attribute. Therefore, complex supraorganismal systems, including presentday civilization, can return to their ancestral potential immortality without losing their achieved structural complexity. The main obstacle to rejuvenating civilization is not the nature of things, but the mindset of human beings.
      PubDate: 2018-01-01
      DOI: 10.1134/S2079057018010071
  • Aging of the Population in Kazakhstan. 1. Problems and Opportunities
    • Abstract: This article discusses aspects of population aging in the Republic of Kazakhstan. The demographic parameters of aging are analyzed, as well as their implications for various spheres of Kazakh society, such as healthcare, social security, and social services.
      PubDate: 2018-01-01
      DOI: 10.1134/S2079057018010113
  • A Model of Social Exclusion of Elderly People in Siberian Regions
    • Abstract: This paper presents the results of construction and approbation of a theoretical model for measuring social exclusion of the elder population in Siberian regions. This study is based on the results of a sociological survey (2016) in three Russian regions: Altai krai, Zabaikalskiy krai, and Kemerovo oblast (n = 779, aged 55 (women) and 60 (men) years and older). The theoretical model includes the following components: social and economic (material) deprivation, deprivation of social rights (access to social institutes and services), deprivation of security (a safe environment), deprivation of social participation, cultural (normative) disintegration, and social autism. These components and indicators are specific for the group of people at retirement age, which is a priori a group potentially at risk of social exclusion. Social exclusion, as a condition and situation of deprivation, can be estimated directly from the intensity of its components. The model has a one-sided effect; i.e., the intensity of one of the exclusion indices can lead to an increased intensity of social exclusion. Based on the operationalized components of social exclusion, the index of exclusion components and the total social-exclusion index for elderly people, including its regional correlations, were assessed. The results of a posteriori testing of the proposed model demonstrate a good correlation between theoretical and empirical models of social exclusion in elderly people.
      PubDate: 2018-01-01
      DOI: 10.1134/S2079057018010083
  • Community-Acquired Bacterial Pneumonia and Comorbidity in Elderly Patients
    • Abstract: We have analyzed the clinical course of pneumonia in 67 elderly patients (39 women and 28 men, the average age: 74.4 ± 5.2 years) with chronic heart failure and chronic obstructive pulmonary disease (COPD). The patients were divided into two groups: with COPD (group 1) and without COPD (group 2). Pharmacological treatment incorporating ampicillin and sulbactam was performed taking into account clinical laboratory indices (temperature, oxygen saturation, and levels of acute-phase proteins (ESRs)). The normalization of temperature and oxygen saturation was observed on day 3–4 in group 1 and on day 2 in group 2; normalization of leukocyte content and erythrocyte sedimentation rate was observed on day 12–13 and 7–8, respectively; and the acute phase indicators (C-reactive protein, fibrinogen) were normalized on day 7 and 5, respectively. Positive dynamics of chest X-ray analysis was observed on day 13 in patients of group 1 (the second control and the use of levofloxacin as alternative to the antibiotic previously used) and on day 8 in patients of group 2 (the first control).
      PubDate: 2018-01-01
      DOI: 10.1134/S2079057018010046
  • The Advisability of Neoadjuvant Chemoradiotherapy of Rectal Cancer in
           Geriatric Patients
    • Abstract: A comparative analysis of the efficacy and safety of neoadjuvant chemoradiotherapy (CRT) in colorectal- cancer patients older and younger than 60 years was performed. It has been determined that the risk of complications of neoadjuvant CRT, as well as the degree of its adverse effect on the outcomes of subsequent surgical treatment, does not significantly depend on the age of the patients. However, the application of preoperative CRT in geriatric patients is associated with a less significant increase in disease-free survival compared with younger patients. Thus, the factor of age should not restrict the use of neoadjuvant CRT in patients with satisfactory general somatic status and the absence of severe complications of the tumor process.
      PubDate: 2018-01-01
      DOI: 10.1134/S207905701801006X
  • Age-Related Aspects of the Involvement of Heat Shock Proteins in the
           Pathogenesis of Osteoarthritis
    • Authors: M. A. Kabalyk
      Pages: 276 - 280
      Abstract: The purpose of the study is to find the age-related features of changes in the levels of heat shock proteins (HSPs), chemokines, and a marker of collagen degradation in the blood of patients with osteoarthritis. The survey revealed that the involvement of HSPs in the pathogenesis of osteoarthrosis seems to be a complex and multilevel process. Under the influence of external risk factors, HSP70 acts as an adjuvant to the immune reaction involving chemokine CXCL17. Low levels of HSPs do not allow them to act as an autoimmune factor in the interaction with Toll-like receptors of immunocompetent cells, but they obviously contribute to the CXCL17-dependent activation of dendritic cells and macrophages that initiate local inflammation involving key cytokines, including TNF-α. Chondrocytes and osteoblasts subjected to a cytokine attack are not able to respond fully to the overexpression of HSP70 and HSP27 for whatever reason. With aging, the pathophysiology of osteoarthritis enters the phase of the local tissue reaction, where the processes of hypertrophic differentiation of chondrocytes and osteo-like cells of subchondral bone play an important role.
      PubDate: 2017-10-01
      DOI: 10.1134/s2079057017040063
      Issue No: Vol. 7, No. 4 (2017)
  • Prediction of Life Expectancy in Prostate Cancer Patients Based on the
           Kinetic Theory of the Aging of Living Systems
    • Authors: A. A. Viktorov; G. M. Zharinov; N. Yu. Neklasova; E. E. Morozova
      Pages: 290 - 295
      Abstract: We propose a method for the prediction of life expectancy (LE) in patients diagnosed with prostate cancer based on the kinetic theory of the aging of living systems. The life expectancy (survival time) is calculated from the differential equation for the rate of aging for three different life stages—“normal” life, life with prostate cancer, and life after combination therapy for prostate cancer. The method is based on the statistical correlation between the growth rate of the level of prostate specific antigen (PSA level) or the PSA doubling time (PSA DT) before therapy and the survival time: the higher the PSA DT is, the greater is the LE. The adequacy of prediction is proved by the satisfactory agreement rate of experimental data on survival time obtained in the group of patients from “fast PSA DT” and “slow PSA DT” categories. The prediction error of group LE is due to the completeness and reliability of the medical parameters and baseline values. Detailed monitoring of the basic health parameters throughout life for each patient in each analyzed group is needed to minimize such a prediction error. The absence of this particular information makes it impossible to predict individual life expectancy.
      PubDate: 2017-10-01
      DOI: 10.1134/s2079057017040142
      Issue No: Vol. 7, No. 4 (2017)
  • Age-Related Changes in the Expression of Lamin B Receptors in Human Dermal
    • Authors: N. N. Golubtsova; F. N. Filippov; A. G. Gunin
      Pages: 296 - 301
      Abstract: The goal of this research was to study the content of lamin B receptors in human dermal fibroblasts during different age periods (from a 20-week pregnancy to the age of 85) in correlation with their proliferative activity. Lamin B receptors and proliferating cell nuclear antigen (PCNA) were identified in skin sections by indirect immunohistochemistry. Our results have shown that an increase in the share of fibroblasts with positive staining for the lamin B receptors and an increase in the expression level of lamin B receptors in fibroblast nuclei are observed during the period from age zero to 20 years of age as compared with other age periods. The total fibroblast count, including positively PCNA-stained dermal fibroblasts, decreased most significantly from the age of 20. The increase in the content of lamin B receptors in dermal fibroblasts, which is observed from birth until the age of 20, can be considered one of the triggering moments leading to the agedependent decrease in counts of human dermal fibroblasts.
      PubDate: 2017-10-01
      DOI: 10.1134/s2079057017040051
      Issue No: Vol. 7, No. 4 (2017)
  • Age-Related Changes in the Content of Sirtuin 1 in Human Dermal
    • Authors: N. N. Golubtsova; F. N. Filippov; A. G. Gunin
      Pages: 302 - 306
      Abstract: The goal of our work was to examine the localization and expression level of sirtuin 1 (SIRT1) in human dermal fibroblasts at different stages of ontogenesis, as well as to identify the role of SIRT1 in skin aging. The study was based on an autopsy skin material sampled from fetuses dying prenatally in the 20th to 40th week of gestation and from people dying in the period starting from birth to the age of 85 years. SIRT1 and the proliferating cell nuclear antigen (PCNA) were detected by the indirect immunohistochemical method. The results of our study have shown that the SIRT1 level decreases in dermal fibroblasts during the period from birth until the age of 85 and that the proliferative activity of dermal fibroblasts and their counts are steadily reduced. The decreasing content of SIRT1 in dermal fibroblasts with age correlates with a reduction of their proliferative activity and can be considered as one of the mechanisms for inhibition of the proliferation of dermal fibroblasts.
      PubDate: 2017-10-01
      DOI: 10.1134/s207905701704004x
      Issue No: Vol. 7, No. 4 (2017)
  • Age Aspects of the Muscular-Tonic and Urological Syndromes in Men with
           Disorders of the Pelvic Functions: the Features of Clinic, Diagnostics,
           and Treatment
    • Authors: V. S. Myakotnykh; V. V. Tretyakov; A. A. Balbert
      Pages: 307 - 312
      Abstract: A comparative examination of 100 patients of different ages suffering from disorders of micturition, erectile function, and pelvic pain identified age-related peculiarities of these pathological manifestations. Irritative disorders of urination were detected significantly more frequently among persons of young and middle age than the elderly, and obstructive-related disorders were more frequent in the elderly. In elderly and senile ages, a reduced contractility of the detrusor was more prevalent, and an increased tone of striated sphincter of the urethra and bladder hyperactivity was more prevalent at a younger age. A long-existing spasm of some muscle formations of the lumbar, pelvic, and femoral regions has been shown to participate in the genesis of urinary symptoms, erectile dysfunction, and pelvic pain. A high effectiveness against disorders of micturition, erectile function, and pelvic pain was achieved, regardless of the age of the patients, with manual therapy, physiotherapy, and botulinum therapy. It is recommended for the diagnosis of urological pathology to involve specialists in the field of neurology and manual therapy. In cases of diagnosis of muscular-tonic disorders not etiologically associated with pathological processes in the organs of the urogenital system, it is recommended to include methods such as manual therapy, physiotherapy, and botulinum therapy in the complex of therapeutic measures.
      PubDate: 2017-10-01
      DOI: 10.1134/s2079057017040099
      Issue No: Vol. 7, No. 4 (2017)
  • Interrelation of Biological Aging Rates with Neurophysiological Features
           in Patients with Occupational Neurointoxications
    • Authors: O. I. Shevchenko; O. L. Lakhman; E. V. Katamanova
      Pages: 313 - 318
      Abstract: Brain functional activity was studied patients hospitalized with occupational neurontoxications in order to reveal the neurophysiological features of the development of accelerated biological aging in working persons exposed to neurotoxicants. The study showed that patients with occupational neurointoxications are characterized in an average of 85% cases by premature aging. The typical neurophysiological feature of this contingent is an increased latency of the P2 peak of visual evoked potentials. The common signs of lesions of cerebral structures in occupational mercury intoxication in accelerated biological aging were determined, irrespective of the disease stage. On the basis of the analysis of the correlations, it is established that the consequence of chronic exposure to metal mercury vapors and the cause of accelerated biological aging at occupational neurointoxications is a permanent disorganization of the functional activity of the brain, which manifests itself as cortical and subcortical disturbances of sensory regulatory systems of the brain.
      PubDate: 2017-10-01
      DOI: 10.1134/s2079057017040129
      Issue No: Vol. 7, No. 4 (2017)
  • Pineamin Increases Melatonin Synthesis in Pineal Gland of Elderly People
    • Authors: S. V. Trofimova; N. S. Linkova; A. A. Klimenko; T. V. Kvetnaia; V. Kh. Khavinson
      Pages: 319 - 322
      Abstract: The effect of a pineal gland polypeptide complex, Pineamin, on urine excretion of 6-sulfatoxymelatonin (6-SOMT) was investigated by immunoenzyme assay in 55 elderly patients with decreased melatonin formation. Pineamin at a dose of 100 mg increased the level of 6-SOMT excretion in overnight urine by 1.9 times in comparison with the respective indicator before the treatment. A similar effect was previously obtained upon the administration of Epitalamin, which also facilitated the restoration of melatonin synthesis in human and animal pineal glands affected by aging. Hence, Pineamin and Epitalamin exhibit a one-directional stimulating property with respect to the melatonin-forming function of the pineal gland in elderly people.
      PubDate: 2017-10-01
      DOI: 10.1134/s2079057017040130
      Issue No: Vol. 7, No. 4 (2017)
  • Donor Age Affects Behavior and Sensibility of Bone Marrow Cells to Copper
           Ions in Primary Culture
    • Authors: A. I. Bozhkov; S. L. Ohiienko; Yu. A. Kuznetsova; A. Yu. Bondar’; V. P. Marchenko; M. S. Gumennaya
      Pages: 336 - 344
      Abstract: In the primary culture of bone marrow cells obtained from young (3-month-old) and old (20-month-old) rats, the change in the number of cells from day 0 to day 4, the pattern of cell morphotypes, and the lifespan of myelocytes, metamyelocytes, and stab and segment neutrophils was studied. It was shown that the number of bone marrow cells obtained from old animals (20-month-old) in the primary culture increased faster than the number of bone marrow cells in young animals (3-month-old). The presence of Copper-induced liver fibrosis in animals had a different effect on the rate of increase in the number of bone marrow cells obtained in young and old animals. The administration of 4 and 8 mmol of CuSO4 ⋅ 5H2O into the culture of bone marrow cells in young and old animals caused a dose-dependent inhibition of proliferative processes in the cells of young animals. When copper ions were administered into the culture of bone marrow cells obtained from old animals, the inhibition of proliferation was less pronounced than for young animals, and a concentration of 8 mmol of CuSO4 ⋅ 5H2O inhibited proliferation to a lesser extent than 4 mmol of CuSO4 ⋅ 5H2O. The presence of liver fibrosis in animals accelerated the process of bone marrow cell death in the primary culture in young and old animals. However, this effect was more pronounced in young animals. It is suggested that bone marrow cells undergo such epigenetic changes, which change their functional properties, during ontogeny.
      PubDate: 2017-10-01
      DOI: 10.1134/s2079057017040026
      Issue No: Vol. 7, No. 4 (2017)
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