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Publisher: Springer-Verlag   (Total: 2355 journals)

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Showing 1 - 200 of 2355 Journals sorted alphabetically
3D Research     Hybrid Journal   (Followers: 19, SJR: 0.214, h-index: 10)
4OR: A Quarterly J. of Operations Research     Hybrid Journal   (Followers: 9, SJR: 1.073, h-index: 25)
AAPS J.     Hybrid Journal   (Followers: 20, SJR: 1.192, h-index: 74)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6, SJR: 0.718, h-index: 54)
Abdominal Imaging     Hybrid Journal   (Followers: 14, SJR: 0.723, h-index: 60)
Abhandlungen aus dem Mathematischen Seminar der Universitat Hamburg     Hybrid Journal   (Followers: 2, SJR: 0.447, h-index: 12)
Academic Psychiatry     Full-text available via subscription   (Followers: 22, SJR: 0.492, h-index: 32)
Academic Questions     Hybrid Journal   (Followers: 7, SJR: 0.135, h-index: 6)
Accreditation and Quality Assurance: J. for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 26, SJR: 0.378, h-index: 30)
Acoustical Physics     Hybrid Journal   (Followers: 11, SJR: 0.355, h-index: 20)
Acoustics Australia     Hybrid Journal  
Acta Analytica     Hybrid Journal   (Followers: 7, SJR: 0.387, h-index: 6)
Acta Applicandae Mathematicae     Hybrid Journal   (Followers: 1, SJR: 0.624, h-index: 34)
Acta Biotheoretica     Hybrid Journal   (Followers: 5, SJR: 0.419, h-index: 25)
Acta Diabetologica     Hybrid Journal   (Followers: 14, SJR: 1.318, h-index: 46)
Acta Endoscopica     Hybrid Journal   (Followers: 1, SJR: 0.113, h-index: 8)
acta ethologica     Hybrid Journal   (Followers: 4, SJR: 0.465, h-index: 23)
Acta Geochimica     Hybrid Journal   (Followers: 3)
Acta Geodaetica et Geophysica     Hybrid Journal   (Followers: 1, SJR: 0.294, h-index: 13)
Acta Geotechnica     Hybrid Journal   (Followers: 7, SJR: 1.818, h-index: 22)
Acta Informatica     Hybrid Journal   (Followers: 5, SJR: 0.524, h-index: 32)
Acta Mathematica     Hybrid Journal   (Followers: 11, SJR: 8.021, h-index: 47)
Acta Mathematica Hungarica     Hybrid Journal   (Followers: 2, SJR: 0.53, h-index: 29)
Acta Mathematica Sinica, English Series     Hybrid Journal   (Followers: 5, SJR: 0.406, h-index: 30)
Acta Mathematica Vietnamica     Hybrid Journal   (SJR: 0.451, h-index: 5)
Acta Mathematicae Applicatae Sinica, English Series     Hybrid Journal   (SJR: 0.22, h-index: 20)
Acta Mechanica     Hybrid Journal   (Followers: 19, SJR: 0.898, h-index: 52)
Acta Mechanica Sinica     Hybrid Journal   (Followers: 5, SJR: 0.426, h-index: 29)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 5, SJR: 0.525, h-index: 18)
Acta Meteorologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.524, h-index: 14)
Acta Neurochirurgica     Hybrid Journal   (Followers: 6, SJR: 0.833, h-index: 73)
Acta Neurologica Belgica     Hybrid Journal   (SJR: 0.348, h-index: 27)
Acta Neuropathologica     Hybrid Journal   (Followers: 3, SJR: 6.61, h-index: 117)
Acta Oceanologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.295, h-index: 17)
Acta Parasitologica     Hybrid Journal   (Followers: 9, SJR: 0.581, h-index: 28)
Acta Physiologiae Plantarum     Hybrid Journal   (Followers: 2, SJR: 0.551, h-index: 39)
Acta Politica     Hybrid Journal   (Followers: 13, SJR: 0.658, h-index: 20)
Activitas Nervosa Superior     Hybrid Journal  
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 5, SJR: 0.103, h-index: 4)
ADHD Attention Deficit and Hyperactivity Disorders     Hybrid Journal   (Followers: 20, SJR: 0.871, h-index: 15)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 7)
Administration and Policy in Mental Health and Mental Health Services Research     Partially Free   (Followers: 15, SJR: 0.795, h-index: 40)
Adsorption     Hybrid Journal   (Followers: 4, SJR: 0.774, h-index: 52)
Advances in Applied Clifford Algebras     Hybrid Journal   (Followers: 3, SJR: 0.319, h-index: 15)
Advances in Atmospheric Sciences     Hybrid Journal   (Followers: 34, SJR: 0.959, h-index: 44)
Advances in Computational Mathematics     Hybrid Journal   (Followers: 15, SJR: 1.255, h-index: 44)
Advances in Contraception     Hybrid Journal   (Followers: 3)
Advances in Data Analysis and Classification     Hybrid Journal   (Followers: 52, SJR: 1.113, h-index: 14)
Advances in Gerontology     Partially Free   (Followers: 9, SJR: 0.141, h-index: 3)
Advances in Health Sciences Education     Hybrid Journal   (Followers: 23, SJR: 1.397, h-index: 42)
Advances in Manufacturing     Hybrid Journal   (Followers: 3, SJR: 0.2, h-index: 4)
Advances in Polymer Science     Hybrid Journal   (Followers: 40, SJR: 0.637, h-index: 89)
Advances in Therapy     Hybrid Journal   (Followers: 5, SJR: 0.79, h-index: 44)
Aegean Review of the Law of the Sea and Maritime Law     Hybrid Journal   (Followers: 7)
Aequationes Mathematicae     Hybrid Journal   (Followers: 2, SJR: 0.882, h-index: 23)
Aerobiologia     Hybrid Journal   (Followers: 1, SJR: 0.511, h-index: 36)
Aesthetic Plastic Surgery     Hybrid Journal   (Followers: 9, SJR: 0.821, h-index: 49)
African Archaeological Review     Hybrid Journal   (Followers: 15, SJR: 0.612, h-index: 24)
Afrika Matematika     Hybrid Journal   (Followers: 1, SJR: 0.248, h-index: 6)
AGE     Hybrid Journal   (Followers: 7, SJR: 1.358, h-index: 33)
Ageing Intl.     Hybrid Journal   (Followers: 7, SJR: 0.337, h-index: 10)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
Aging Clinical and Experimental Research     Hybrid Journal   (Followers: 3, SJR: 0.529, h-index: 55)
Agricultural Research     Hybrid Journal   (Followers: 3)
Agriculture and Human Values     Hybrid Journal   (Followers: 12, SJR: 1.197, h-index: 49)
Agroforestry Systems     Hybrid Journal   (Followers: 19, SJR: 0.64, h-index: 56)
Agronomy for Sustainable Development     Hybrid Journal   (Followers: 10, SJR: 1.732, h-index: 59)
AI & Society     Hybrid Journal   (Followers: 6, SJR: 0.171, h-index: 19)
AIDS and Behavior     Hybrid Journal   (Followers: 13, SJR: 2.006, h-index: 71)
Air Quality, Atmosphere & Health     Hybrid Journal   (Followers: 3, SJR: 0.706, h-index: 19)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Algebra and Logic     Hybrid Journal   (Followers: 3, SJR: 0.566, h-index: 18)
Algebra Universalis     Hybrid Journal   (Followers: 2, SJR: 0.388, h-index: 22)
Algebras and Representation Theory     Hybrid Journal   (Followers: 1, SJR: 0.868, h-index: 20)
Algorithmica     Hybrid Journal   (Followers: 7, SJR: 0.898, h-index: 56)
Allergo J.     Full-text available via subscription   (Followers: 1, SJR: 0.183, h-index: 20)
Allergo J. Intl.     Hybrid Journal   (Followers: 2)
Alpine Botany     Hybrid Journal   (Followers: 4, SJR: 0.729, h-index: 20)
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 3, SJR: 1.392, h-index: 32)
AMBIO     Hybrid Journal   (Followers: 14, SJR: 1.094, h-index: 87)
American J. of Cardiovascular Drugs     Hybrid Journal   (Followers: 10, SJR: 0.864, h-index: 39)
American J. of Community Psychology     Hybrid Journal   (Followers: 24, SJR: 1.237, h-index: 83)
American J. of Criminal Justice     Hybrid Journal   (Followers: 6, SJR: 0.634, h-index: 13)
American J. of Cultural Sociology     Hybrid Journal   (Followers: 11, SJR: 0.283, h-index: 3)
American J. of Dance Therapy     Hybrid Journal   (Followers: 4, SJR: 0.175, h-index: 13)
American J. of Potato Research     Hybrid Journal   (Followers: 2, SJR: 0.558, h-index: 35)
American J. of Psychoanalysis     Hybrid Journal   (Followers: 21, SJR: 0.293, h-index: 13)
American Sociologist     Hybrid Journal   (Followers: 12, SJR: 0.18, h-index: 13)
Amino Acids     Hybrid Journal   (Followers: 8, SJR: 1.362, h-index: 83)
AMS Review     Partially Free   (Followers: 4)
Analog Integrated Circuits and Signal Processing     Hybrid Journal   (Followers: 5, SJR: 0.21, h-index: 37)
Analysis and Mathematical Physics     Hybrid Journal   (Followers: 3, SJR: 0.665, h-index: 7)
Analysis in Theory and Applications     Hybrid Journal  
Analysis of Verbal Behavior     Hybrid Journal   (Followers: 4)
Analytical and Bioanalytical Chemistry     Hybrid Journal   (Followers: 28, SJR: 1.096, h-index: 123)
Anatomical Science Intl.     Hybrid Journal   (Followers: 2, SJR: 0.301, h-index: 26)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3, SJR: 2.212, h-index: 69)
Animal Cognition     Hybrid Journal   (Followers: 16, SJR: 1.122, h-index: 55)
Annales françaises de médecine d'urgence     Hybrid Journal   (Followers: 1, SJR: 0.156, h-index: 4)
Annales Henri Poincaré     Hybrid Journal   (Followers: 3, SJR: 1.377, h-index: 32)
Annales mathématiques du Québec     Hybrid Journal   (Followers: 4)
Annali dell'Universita di Ferrara     Hybrid Journal   (SJR: 0.504, h-index: 14)
Annali di Matematica Pura ed Applicata     Hybrid Journal   (Followers: 1, SJR: 1.167, h-index: 26)
Annals of Behavioral Medicine     Hybrid Journal   (Followers: 11, SJR: 2.112, h-index: 98)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18, SJR: 1.182, h-index: 94)
Annals of Combinatorics     Hybrid Journal   (Followers: 3, SJR: 0.849, h-index: 15)
Annals of Data Science     Hybrid Journal   (Followers: 8)
Annals of Dyslexia     Hybrid Journal   (Followers: 9, SJR: 0.857, h-index: 40)
Annals of Finance     Hybrid Journal   (Followers: 28, SJR: 0.686, h-index: 14)
Annals of Forest Science     Hybrid Journal   (Followers: 4, SJR: 0.929, h-index: 57)
Annals of Global Analysis and Geometry     Hybrid Journal   (Followers: 1, SJR: 1.136, h-index: 23)
Annals of Hematology     Hybrid Journal   (Followers: 14, SJR: 1.117, h-index: 62)
Annals of Mathematics and Artificial Intelligence     Hybrid Journal   (Followers: 6, SJR: 0.593, h-index: 42)
Annals of Microbiology     Hybrid Journal   (Followers: 9, SJR: 0.402, h-index: 26)
Annals of Nuclear Medicine     Hybrid Journal   (Followers: 5, SJR: 0.68, h-index: 45)
Annals of Operations Research     Hybrid Journal   (Followers: 8, SJR: 1.186, h-index: 78)
Annals of Ophthalmology     Hybrid Journal   (Followers: 9)
Annals of Regional Science     Hybrid Journal   (Followers: 7, SJR: 0.405, h-index: 42)
Annals of Software Engineering     Hybrid Journal   (Followers: 12)
Annals of Solid and Structural Mechanics     Hybrid Journal   (Followers: 10, SJR: 0.553, h-index: 8)
Annals of Surgical Oncology     Hybrid Journal   (Followers: 11, SJR: 1.902, h-index: 127)
Annals of Telecommunications     Hybrid Journal   (Followers: 7, SJR: 0.315, h-index: 25)
Annals of the Institute of Statistical Mathematics     Hybrid Journal   (Followers: 1, SJR: 0.931, h-index: 31)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 5, SJR: 0.992, h-index: 87)
Apidologie     Hybrid Journal   (Followers: 4, SJR: 1.14, h-index: 57)
APOPTOSIS     Hybrid Journal   (Followers: 8, SJR: 1.554, h-index: 87)
Applicable Algebra in Engineering, Communication and Computing     Hybrid Journal   (Followers: 2, SJR: 0.354, h-index: 27)
Applications of Mathematics     Hybrid Journal   (Followers: 1, SJR: 0.274, h-index: 20)
Applied Biochemistry and Biotechnology     Hybrid Journal   (Followers: 44, SJR: 0.575, h-index: 80)
Applied Biochemistry and Microbiology     Hybrid Journal   (Followers: 17, SJR: 0.267, h-index: 26)
Applied Cancer Research     Open Access  
Applied Categorical Structures     Hybrid Journal   (Followers: 2, SJR: 0.361, h-index: 21)
Applied Composite Materials     Hybrid Journal   (Followers: 47, SJR: 0.705, h-index: 35)
Applied Entomology and Zoology     Partially Free   (Followers: 2, SJR: 0.554, h-index: 34)
Applied Geomatics     Hybrid Journal   (Followers: 3, SJR: 0.323, h-index: 9)
Applied Geophysics     Hybrid Journal   (Followers: 7, SJR: 0.541, h-index: 13)
Applied Intelligence     Hybrid Journal   (Followers: 12, SJR: 0.777, h-index: 43)
Applied Magnetic Resonance     Hybrid Journal   (Followers: 3, SJR: 0.358, h-index: 34)
Applied Mathematics & Optimization     Hybrid Journal   (Followers: 4, SJR: 0.955, h-index: 33)
Applied Mathematics - A J. of Chinese Universities     Hybrid Journal   (SJR: 0.275, h-index: 8)
Applied Mathematics and Mechanics     Hybrid Journal   (Followers: 4, SJR: 0.37, h-index: 26)
Applied Microbiology and Biotechnology     Hybrid Journal   (Followers: 60, SJR: 1.262, h-index: 161)
Applied Physics A     Hybrid Journal   (Followers: 7, SJR: 0.535, h-index: 121)
Applied Physics B: Lasers and Optics     Hybrid Journal   (Followers: 23, SJR: 0.983, h-index: 104)
Applied Psychophysiology and Biofeedback     Hybrid Journal   (Followers: 8, SJR: 0.677, h-index: 47)
Applied Research in Quality of Life     Hybrid Journal   (Followers: 10, SJR: 0.288, h-index: 15)
Applied Solar Energy     Hybrid Journal   (Followers: 17, SJR: 0.251, h-index: 6)
Applied Spatial Analysis and Policy     Hybrid Journal   (Followers: 4, SJR: 0.351, h-index: 9)
Aquaculture Intl.     Hybrid Journal   (Followers: 22, SJR: 0.613, h-index: 40)
Aquarium Sciences and Conservation     Hybrid Journal   (Followers: 1)
Aquatic Ecology     Hybrid Journal   (Followers: 30, SJR: 0.646, h-index: 44)
Aquatic Geochemistry     Hybrid Journal   (Followers: 3, SJR: 0.764, h-index: 39)
Aquatic Sciences     Hybrid Journal   (Followers: 12, SJR: 1.172, h-index: 53)
Arabian J. for Science and Engineering     Hybrid Journal   (Followers: 5, SJR: 0.345, h-index: 20)
Arabian J. of Geosciences     Hybrid Journal   (Followers: 1, SJR: 0.417, h-index: 16)
Archaeological and Anthropological Sciences     Hybrid Journal   (Followers: 21, SJR: 1.056, h-index: 15)
Archaeologies     Hybrid Journal   (Followers: 12, SJR: 0.397, h-index: 13)
Archiv der Mathematik     Hybrid Journal   (Followers: 1, SJR: 0.597, h-index: 29)
Archival Science     Hybrid Journal   (Followers: 53, SJR: 0.804, h-index: 22)
Archive for History of Exact Sciences     Hybrid Journal   (Followers: 7, SJR: 0.28, h-index: 15)
Archive for Mathematical Logic     Hybrid Journal   (Followers: 1, SJR: 0.946, h-index: 23)
Archive for Rational Mechanics and Analysis     Hybrid Journal   (SJR: 4.091, h-index: 66)
Archive of Applied Mechanics     Hybrid Journal   (Followers: 4, SJR: 0.865, h-index: 40)
Archives and Museum Informatics     Hybrid Journal   (Followers: 118)
Archives of Computational Methods in Engineering     Hybrid Journal   (Followers: 4, SJR: 2.841, h-index: 40)
Archives of Dermatological Research     Hybrid Journal   (Followers: 6, SJR: 0.9, h-index: 65)
Archives of Environmental Contamination and Toxicology     Hybrid Journal   (Followers: 10, SJR: 0.846, h-index: 84)
Archives of Gynecology and Obstetrics     Hybrid Journal   (Followers: 17, SJR: 0.695, h-index: 47)
Archives of Microbiology     Hybrid Journal   (Followers: 8, SJR: 0.702, h-index: 85)
Archives of Orthopaedic and Trauma Surgery     Hybrid Journal   (Followers: 8, SJR: 1.039, h-index: 56)
Archives of Osteoporosis     Hybrid Journal   (Followers: 2, SJR: 1.092, h-index: 13)
Archives of Sexual Behavior     Hybrid Journal   (Followers: 9, SJR: 1.198, h-index: 74)
Archives of Toxicology     Hybrid Journal   (Followers: 16, SJR: 1.595, h-index: 76)
Archives of Virology     Hybrid Journal   (Followers: 5, SJR: 1.086, h-index: 90)
Archives of Women's Mental Health     Hybrid Journal   (Followers: 13, SJR: 1.264, h-index: 50)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2, SJR: 1.2, h-index: 42)
ArgoSpine News & J.     Hybrid Journal   (SJR: 0.102, h-index: 3)
Argumentation     Hybrid Journal   (Followers: 5, SJR: 0.295, h-index: 18)
Arid Ecosystems     Hybrid Journal   (Followers: 3)
Arkiv för Matematik     Hybrid Journal   (Followers: 1, SJR: 0.948, h-index: 22)
Arnold Mathematical J.     Hybrid Journal   (Followers: 1)
Arthropod-Plant Interactions     Hybrid Journal   (Followers: 1, SJR: 0.797, h-index: 17)
Arthroskopie     Hybrid Journal   (Followers: 1, SJR: 0.145, h-index: 8)
Artificial Intelligence and Law     Hybrid Journal   (Followers: 9, SJR: 0.288, h-index: 25)
Artificial Intelligence Review     Hybrid Journal   (Followers: 14, SJR: 0.948, h-index: 48)
Artificial Life and Robotics     Hybrid Journal   (Followers: 7, SJR: 0.231, h-index: 14)
Asia Europe J.     Hybrid Journal   (Followers: 4, SJR: 0.247, h-index: 9)
Asia Pacific Education Review     Hybrid Journal   (Followers: 9, SJR: 0.371, h-index: 17)
Asia Pacific J. of Management     Hybrid Journal   (Followers: 12, SJR: 1.676, h-index: 50)
Asia-Pacific Education Researcher     Hybrid Journal   (Followers: 11, SJR: 0.353, h-index: 13)
Asia-Pacific Financial Markets     Hybrid Journal   (Followers: 2, SJR: 0.19, h-index: 15)
Asia-Pacific J. of Atmospheric Sciences     Hybrid Journal   (Followers: 20, SJR: 1.006, h-index: 14)
Asian Business & Management     Hybrid Journal   (Followers: 7, SJR: 0.41, h-index: 10)
Asian J. of Business Ethics     Hybrid Journal   (Followers: 7)
Asian J. of Criminology     Hybrid Journal   (Followers: 5, SJR: 0.263, h-index: 8)
AStA Advances in Statistical Analysis     Hybrid Journal   (Followers: 2, SJR: 0.681, h-index: 15)
AStA Wirtschafts- und Sozialstatistisches Archiv     Hybrid Journal   (Followers: 5, SJR: 0.195, h-index: 5)
ästhetische dermatologie & kosmetologie     Full-text available via subscription  

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Journal Cover Advances in Gerontology
  [SJR: 0.141]   [H-I: 3]   [9 followers]  Follow
    
   Partially Free Journal Partially Free Journal
   ISSN (Print) 2079-0570 - ISSN (Online) 2079-0589
   Published by Springer-Verlag Homepage  [2355 journals]
  • Glycation, antiglycation, and deglycation: Their role in aging mechanisms
           and geroprotective effects (literature review)
    • Authors: V. V. Emel’yanov
      Pages: 1 - 9
      Abstract: The biochemistry of glycation and its role in the disruption of cell metabolism and development of age-related pathologies have been reviewed in this manuscript based on literature data published, for the most part, in the last 5 years. The effects of antiglycation and deglycation actions of endogenous enzymes, as well as of exogenous chemical compounds of natural and synthetic nature on the process of aging, were evaluated.
      PubDate: 2017-01-01
      DOI: 10.1134/s2079057017010064
      Issue No: Vol. 7, No. 1 (2017)
       
  • The role of circadian rhythms and the “cellular clock” in
           age-associated diseases
    • Authors: A. V. Panchenko; E. A. Gubareva; V. N. Anisimov
      Pages: 10 - 16
      Abstract: Circadian oscillations are characteristic of almost all processes in living organisms. Disturbances in circadian rhythms may constitute either a cause or a consequence of different diseases. The article analyzes literature data on the role of changes in the circadian rhythms and the expression of clock genes in the development of neurodegenerative and cardiovascular diseases, metabolic syndrome, and type 2 diabetes mellitus in human beings and animals.
      PubDate: 2017-01-01
      DOI: 10.1134/s2079057017010131
      Issue No: Vol. 7, No. 1 (2017)
       
  • Molecular mechanisms of cell death in retina during development of
           age-related macular degeneration
    • Authors: D. V. Telegina; O. S. Kozhevnikova; N. G. Kolosova
      Pages: 17 - 24
      Abstract: Age-related macular degeneration (AMD) is a chronic progressive disease characterized by damage to the central retina zone. Changes in choriocapillaries, retinal pigment epithelium (RPE), and Bruch’s membrane (typical for aging) underlie AMD pathogenesis; however, the mechanisms launching the transfer of typical age-related changes in the pathological process are unknown. The death of photoreceptors and irreversible loss of vision become the results of pathological changes in RPE and choroid. In spite of intensive studies of AMD pathogenesis, information on molecular genetic preconditions of the events leading to the death of photoreceptors (as well as about the pathways of their death) is extremely limited; this complicates the search for efficient methods of AMD treatment (first of all, the most widely spread atrophic (“dry”) form of the disease). Recent studies demonstrated that not only apoptotic but also autophagic and necrotic signaling cascades are involved in the cellular death of retinal cells. The published data on three main forms of the programmed cell death (apoptosis, necrosis, and autophagy) and their role in AMD pathogenesis are summarized in the present review.
      PubDate: 2017-01-01
      DOI: 10.1134/s2079057017010155
      Issue No: Vol. 7, No. 1 (2017)
       
  • The contribution of stress and its mediators to the ontopathogeny of
           infections: a focus on the interactions of cytokines and glucocorticoids
    • Authors: V. I. Goudochnikov
      Pages: 25 - 28
      Abstract: The present work is a bibliographical review of the participation of glucocorticoids, cytokines, and other bioregulators of stress in the ontogeny of the immune system and in the pathogeny of infections. In addition, the age-related dynamics of and gender differences in morbidity and mortality caused by three infectious diseases (AIDS, pulmonary tuberculosis and sepsis) were evaluated in southern Brazilian states during three chronological periods. The results obtained indicate the need to pay more attention to the subclinical role played by infectious agents in the etiopathogeny of other chronic degenerative age-related disorders.
      PubDate: 2017-01-01
      DOI: 10.1134/s2079057017010088
      Issue No: Vol. 7, No. 1 (2017)
       
  • On the discontinuous character of annuity curves. III. Two forms of
           viability variation in Drosophila melanogaster
    • Authors: I. B. Bychkovskaia; S. V. Mylnikov; G. A. Mozhaev
      Pages: 29 - 34
      Abstract: The validity of the two-component structure of annuity curves in Drosophila melanogaster (line Canton-S) observed in our previous studies has been confirmed. The structure is formed by a combination of a stable five-phase pattern and the variability of phase duration (the latter determines the variability of insect viability). Both the stable and the variable component were preserved over 60 generations of flies. The unconventional type of variability addressed in the present study exists along with the well-known type of variability related to the stochastic variation of the annuity curves. The variance of viability that characterizes the reaction norm remains unchanged in a series of generations as well. Thus, both types of variability can be classified as genetically determined phenomena.
      PubDate: 2017-01-01
      DOI: 10.1134/s2079057017010052
      Issue No: Vol. 7, No. 1 (2017)
       
  • The features of lymph-node reaction to tissue damage in the lymph-drainage
           area in elderly rats
    • Authors: I. V. Maiborodin; M. K. Agzaev; T. M. Ragimova; V. I. Maiborodina
      Pages: 35 - 40
      Abstract: Light microscopy has been used to study the reaction of submandibular lymph nodes (LNs) to surgical damage to the tissues of the maxillofacial region in elderly rats. Connective tissue was more abundant in the LNs of elderly rats than in those of mature animals, regardless of the time of observation (even before surgery). Moreover, the duration of the changes of the volume of the cortical plateau was increased in the old rats, whereas the duration of the changes in paracortex and lymphoid nodules devoid of germinal centers was reduced. The distinctive cytoarchitectonic features included a significant reduction of the number of lymphocytes, mitotic figures, and immuno- and plasmablasts concomitant with the elevation of the number of macrophages, cellular elements that showed signs of destruction, reticulocytes, and red blood cells.
      PubDate: 2017-01-01
      DOI: 10.1134/s2079057017010106
      Issue No: Vol. 7, No. 1 (2017)
       
  • Young and old rats have different strategies of metabolic adaptation to
           Cu-induced liver fibrosis
    • Authors: A. I. Bozhkov; Yu. V. Nikitchenko; E. M. Klimova; O. S. Linkevych; K. M. Lebid; A. M. M. Al-Bahadli; M. M. A. Alsardia
      Pages: 41 - 50
      Abstract: We investigated the role of pro- and antioxidant and immune systems in age-related adaptive reactions to chronic exposure to toxicants (copper ions). For this purpose, we administered multiple doses of copper sulfate to younger and older rats in order to induce liver fibrosis and then measured the parameters of proand antioxidant and immune systems and physiological indices. It was found that Cu-induced liver fibrosis was accompanied by oxidative stress and a significant reduction in cell-mediated immune activity. If oxidative stress was eliminated by the administration of exogenous antioxidants (mix factor), the physical capacity, body weight, and content of red blood cells in rats with fibrosis was recovered. The parameters of cell-mediated immune response recovered more effectively in older animals than in younger ones. The metabolic strategies of adaptation to toxic exposure were different in younger and older animals.
      PubDate: 2017-01-01
      DOI: 10.1134/s2079057017010040
      Issue No: Vol. 7, No. 1 (2017)
       
  • Age-related changes in microcirculation in the cortex of hypertonic rats
    • Authors: I. B. Sokolova; I. V. Sergeev; O. R. Fedotova; N. N. Melnikova; D. P. Dvoretsky
      Pages: 51 - 55
      Abstract: We have studied the density of the microvascular system of the pia matter and perfusion and oxygen saturation of the sensorimotor cortex in hypertonic rats of different ages. We have found that the density of the microvascular system did not decrease, but increased, with age. The perfusion of the cortex decreased, and oxygen saturation of brain tissues increased. By the age of 12 months, the exploratory behavior of rats in an open-field test worsened significantly by all parameters.
      PubDate: 2017-01-01
      DOI: 10.1134/s2079057017010143
      Issue No: Vol. 7, No. 1 (2017)
       
  • An endogenous decline in the homeostatic characteristics of two
           supraorganismal systems from the standpoint of the parametabolic theory of
           aging
    • Authors: A. V. Makrushin; N. V. Aladin
      Pages: 56 - 59
      Abstract: An endogenous decline in the homeostatic characteristics of supraorganismal systems is similar to individual aging. The similarity lies in the fact that this decline, as well as individual aging, is caused by negative consequences of specialization of individual elements constituting the system. These consequences in supraorganismal systems are analogous to the parametabolic processes of an aging individual.
      PubDate: 2017-01-01
      DOI: 10.1134/s2079057017010118
      Issue No: Vol. 7, No. 1 (2017)
       
  • Lamin A and lamin-associated polypeptide 2 (LAP-2) in human skin
           fibroblasts in the process of aging
    • Authors: N. N. Golubtsova; F. N. Filippov; A. G. Gunin
      Pages: 60 - 67
      Abstract: Mutations of lamin genes lead to diseases, one of which is progeria. This disease is caused by violation of splicing of lamin A gene and accumulation of farnesylated prelamin A (progerin) in the nucleus. LAP-2 is an important factor that regulates and stabilizes the nucleoplasmic pool of lamin A. However, roles of lamin A and LAP-2 in renewal regulation of the population of fibroblasts in the human dermis in different age periods still have not been investigated. The purpose of this investigation was to define expression of lamin A and LAP-2 in human dermal fibroblasts at different ages. Lamin A and LAP-2 were detected in skin sections by indirect immunohistochemistry. It was found that the number of fibroblasts containing lamin A gradually decreased from 90.4 to 76.9% from 20 weeks of pregnancy to 85 years. It was revealed that 32% of dermal fibroblasts were positively stained for LAP-2 in the period from 20 weeks of pregnancy to 20 years, 37.8% in the period of 21–40 years, and 49–51% in the period of 41–85 years. Lamin A expression levels in fibroblast nuclei were essentially constant from 20 weeks of pregnancy to 85 years, while LAP-2 content in fibroblast nuclei was reducing from 0 to 20 years as compared with the embryonic period and was gradually increasing after 21 year. The total number of fibroblasts and PCNA-positive fibroblasts in the dermis decreased with age. The most significant decrease in the number of fibroblasts was observed from 20 weeks of pregnancy to 20 years. The results suggest involvement of lamin A and LAP-2 in the age-related decrease in the number of fibroblasts in the human dermis.
      PubDate: 2017-01-01
      DOI: 10.1134/s2079057017010076
      Issue No: Vol. 7, No. 1 (2017)
       
  • Mast cells and aging
    • Authors: N. A. Kutukova; P. G. Nazarov; G. V. Kudryavtseva; V. I. Shishkin
      Pages: 68 - 75
      Abstract: Mast cells (MCs) are present in the skin and mucous membranes, lymphoid organs, intestine wall, and brain, where they are located close to blood and lymphatic vessels and nerve terminals. As a source of a large number of biologically active substances, many of which are released quickly into the environment as a result of degranulation process, mast cells play an essential role in the regulation of physiological processes in the tissues where they are present. Changes in the MC population and activity in tissues during aging is associated with age-related changes of the skin and mucous membranes, as well as the development of centralnervous- system disorders such as itching, headache, joint and muscle pain, memory loss, attention deficit, depression, anxiety and depressive disorders, autism, Alzheimer’s disease, and multiple sclerosis.
      PubDate: 2017-01-01
      DOI: 10.1134/s207905701701009x
      Issue No: Vol. 7, No. 1 (2017)
       
  • Comparative analysis of different geroprotective methods
    • Authors: V. S. Myakotnykh; M. N. Torgashov; K. V. Egorin; V. N. Meshchaninov; I. V. Gavrilov; T. A. Borovkova; E. M. Zvezdina; T. Y. Verzhbitskaya; E. L. Tkachenko
      Pages: 76 - 83
      Abstract: One hundred and ten patients of different ages have undergone a comparative analysis of the efficiency and safety of a number of geroprotective techniques, including the use of dry lead-carbonate baths, hyperbaric oxygenation, therapeutic massage, and reception of oligopeptide preparations containing complexes of lysyl-glutamyl-asparagin and glutamyl-asparagin-arginine complexes (Vezugen and Pinealon). The most pronounced positive impact on indicators of biological age was found during the combined use of these two oligopeptide complexes. The safest ones in terms of influence on a number of biochemical and immunological parameters and on the clinical state of patients were medical massage and oligopeptide preparations. The use of dry carbon dioxide baths and hyperbaric oxygenation, while having an undoubtedly positive influence on the indices of biological age, has a number of limitations and counterindications.
      PubDate: 2017-01-01
      DOI: 10.1134/s207905701701012x
      Issue No: Vol. 7, No. 1 (2017)
       
  • Arterial stiffness in the light of thromboembolic complications in elderly
           patients with atrial fibrillation
    • Authors: I. A. Zolotovskaya; I. L. Davydkin
      Pages: 84 - 89
      Abstract: According to available data reported by numerous national and international studies, one of the parameters reflecting the degree of lesioning of the vascular wall is arterial stiffness, which makes a fundamental contribution to the risk of developing cardiovascular diseases and the total cardiovascular mortality, especially in the elderly. Patients with cardiac arrhythmias, especially with atrial fibrillation (AF), deserve our special care, since it is this group of patients that is susceptible to a high risk of developing primary and recurrent thromboembolic episodes. This category of patients had a very high risk of death and invalidation, considering the age factor and comorbidity of the pathology. The analysis of factors involved in the development of not only AF, but also its complications, is a task necessary to improve technologies of correction. In view of this, the parameter of vascular-wall stiffness, being one of the mechanisms involved in AF maintenance and a risk factor for the development of acute thromboembolic complications, primarily stroke, should be given very serious consideration. This survey aims to discuss the results of studies devoted to arterial stiffness in patients with atrial fibrillation (AF), as well as the issues related to the risk of developing thromboembolic complications in this category of patients.
      PubDate: 2017-01-01
      DOI: 10.1134/s2079057017010167
      Issue No: Vol. 7, No. 1 (2017)
       
  • Morphological features of structural organization of the cerebellum cortex
           in old age
    • Authors: I. A. Balandina; L. M. Zheleznov; A. A. Balandin; P. V. Kosareva; D. V. Borodulin; D. G. Amarantov
      Pages: 90 - 94
      Abstract: In this scientific work, organometric, histological, immunomorphologic, and morphometric parameters of the cerebral cortex of 219 corpses of people (108 men and 111 women) of young and old age have been studied. A comparative analysis of the parameters of bulb-shaped neurons in these ages revealed a decrease of their height and width. It was found that the distance between nerve-cell bodies of the ganglionic layer increases with age, which is obviously associated with disorganization progression and the death of bulbshaped neurons. An increase in the number of immunopositive astrocytes for the glial fibrillary acidic protein, protide S-100, and vimentin in the granular layer and the molecular layer of the cerebral cortex and decline in the number of immunopositive bulb-shaped neurons for neuron-specific enolase and immunonegative for the S-100 protein and vimentin that can be regarded as a manifestation of neurodegeneration. Using immunohistochemical methods in research allows a more nuanced approach to the issues of morphological assessment of the cerebral cortex of elderly people and makes it possible to obtain more objective and complete information on postnatal morphogenesis.
      PubDate: 2017-01-01
      DOI: 10.1134/s2079057017010027
      Issue No: Vol. 7, No. 1 (2017)
       
  • Comparative organometric characteristic of the cerebellum of the young and
           old age
    • Authors: I. A. Balandina; L. M. Zheleznov; A. A. Balandin; P. V. Kosareva; D. V. Borodulin; D. G. Amarantov
      Pages: 95 - 99
      Abstract: This scientific work is based on morphological research of the cerebellums of 219 corpses of people (108 men and 111 women) of young and senile age. Organometric, histological, and morphometric methods were used. During the study, a comparative analysis of the mass, linear dimensions, and thickness of the cerebral cortex in young and senile age was conducted. The regularities of age variability of organometric characteristic of the cerebellum were revealed, and they were found in the reduction of mass and linear dimensions of the cerebellum in people of senile age compared to younger people. It was determined that the thickness of the molecular and granular layers of the cerebellum was characterized by age-related decrease of the parameters. The results of the morphological study can serve as a basis for the identification of certain regularities of age anatomy of the cerebellum and have practical significance as indicators of the norm that allows using these data in diagnostic and therapeutic work.
      PubDate: 2017-01-01
      DOI: 10.1134/s2079057017010039
      Issue No: Vol. 7, No. 1 (2017)
       
  • Neurohumoral changes in rats of different age groups on the background of
           injection of cryopreserved cord blood nucleated cells
    • Authors: Yu. V. Martynova; V. G. Babiychuk; L. A. Sirotenko; N. G. Malova; L. V. Babiychuk
      Pages: 304 - 310
      Abstract: The application of a cryopreserved preparation of UCB NCs to rats was accompanied by enhanced activity of all neurohumoral regulation elements of heart rate, although the absolute parameters in 18- and 24-month-old animals did not reach values similar to those in groups of younger age. We also noticed an increase of the thyroid hormone concentration in the blood serum of the old rats. The concentration decreased with age. In addition, it was shown that the injection of UCB NCs during the animal’s life cycle (every 6 months) made it possible to maintain a functional state of the autonomous nervous system at a “young” physiological level.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040093
      Issue No: Vol. 6, No. 4 (2016)
       
  • Changes in the hormonal status of cardiovascular and the thyroid systems
           in rats with 18-month type 2 diabetes mellitus
    • Authors: K. V. Derkach; P. A. Ignatieva; I. V. Bogush; M. F. Balluzek; A. O. Shpakov
      Pages: 311 - 316
      Abstract: Among the most common complications of type 2 diabetes mellitus (DM2) are disorders of the cardiovascular and the thyroid systems. The functions of these systems may be weakened with increasing age. However, the mechanisms of these disorders, including the role of alterations in the adenylyl cyclase signaling system (ACSS), are not fully elucidated. The objective was to study the thyroid status and ACSS activity of the myocardium and the thyroid gland (TG) of rats with 8- and 18-month DM2 (DM-8 and DM-18) as compared to control animals of the same age (C-8 and C-18). In the myocardium of rats with DM2, an imbalance of β-adrenergic regulation of ACSS was detected, and these disturbances were amplified with increasing age. In the myocardium of rats of the C-18 group, disturbances of ACSS hormonal regulation were also identified but they were less pronounced. In diabetic rats, the levels of free thyroxine and total triiodothyronine decreased, the level of thyroid stimulating hormone (TSH) increased, and the stimulatory effect of TSH on the ACSS in TG was attenuated, which indicates the hypothyroid state in long-term DM2. In the C-18 group, these changes were absent. Thus, in the myocardium and TG of rats with 18-month DM2, the hormonal regulation of ACSS was violated, which may be one of the causes of cardiovascular pathology and hypothyroid states in long-term DM2.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040044
      Issue No: Vol. 6, No. 4 (2016)
       
  • Geriatric aspects in oncocoloproctology (review)
    • Authors: A. A. Sazonov; N. A. Maistrenko
      Pages: 317 - 321
      Abstract: Severe comorbidity significantly limits the application of active surgical tactics with respect to colorectal cancer (CRC) patients of older age groups, leading to the abandonment of necessary radical operations in 20% of cases. Low indicators of the application of adequate surgical tactics are by no means always due to objective difficulties; they may often be caused by the stereotypical approach to solving the problem of treatment of elderly patients, which leads to the unreasonable refusal of surgical intervention. To date, there is no unified concept of surgical treatment of colon cancer patients of elderly and senile age. There is no generally accepted system for determining functional operability in this group of patients, and no specific algorithms have been developed for their preoperative preparation and perioperative management. Therefore, one of the priorities in oncosurgery is the search for new approaches in the surgical treatment of gerontological CRC patients that will make it possible to increase the rate of execution of radical operations and, at the same time, decrease the number of postoperative complications in this numerous group of patients.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040123
      Issue No: Vol. 6, No. 4 (2016)
       
  • System analysis of factors affecting the quality of life of aged people in
           their use of different forms of social services
    • Authors: E. Yu. Golubeva
      Pages: 338 - 342
      Abstract: The paper discusses factors influencing the satisfaction with quality of life (QoL) in aged and old people. QoL is considered in relation to the form of homecare and institutional care in urban and rural places. In rural places QoL is more dependent on the existence of and living with family than on the state of health or welfare position. In urban places, in special housing for lonely aged people and invalids, QoL is determined by the state of health, which allows independence in the fulfillment of everyday self-services. Under conditions of stationary services, the most important factor is the feeling of loneliness and isolation; this sometimes provokes the feelings of life fatigue and depression, which leads to alcohol abuse.
      PubDate: 2016-10-01
      DOI: 10.1134/s2079057016040056
      Issue No: Vol. 6, No. 4 (2016)
       
  • Quality of life for men of different ages in the European Russian North
           and its relationship with self-rated health and hormonal status
    • Authors: L. B. Kim; N. K. Belisheva; A. N. Putyatina; G. S. Russkikh; P. M. Kozhin; O. B. Tsypysheva
      Pages: 343 - 351
      Abstract: Assessment of the quality of life in male inhabitants of the European Russian North revealed decreased indices of the physical health component (the scale of role functioning determined by physical condition) and mental health component (the scales of social-role functioning and role functioning determined by emotional state and mental health) as compared to the inhabitants of Siberia as a control (comparison) group. Men aged under 29 had the highest scores at all scales. The scores decreased with age. The greatest reduction was observed for the scales of general well-being and bodily pain. There was a moderate decrease for the scales of physical functioning, role functioning determined by emotional state, and role functioning determined by physical condition. Quality of life was closely related to the northerners’ self-rated health, pathology index, molecular marker of aging, and biological age. A negative correlation between these values implies deterioration in the physical and mental health with biological age. The quality of life for the northerners also correlated with their hormonal status. There was a relationship between testosterone and three scales of physical health components, i.e., between cortisol and one scale of physical component and between both dehydroepiandrosterone sulfate and insulin and the scales of physical and mental components of health. The effect of various hormones on different age groups of northerners was demonstrated.
      PubDate: 2016-10-01
      DOI: 10.1134/s207905701604007x
      Issue No: Vol. 6, No. 4 (2016)
       
 
 
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