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Publisher: Springer-Verlag (Total: 2351 journals)

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Showing 1 - 200 of 2351 Journals sorted alphabetically
3D Printing in Medicine     Open Access   (Followers: 1)
3D Research     Hybrid Journal   (Followers: 21, SJR: 0.222, CiteScore: 1)
4OR: A Quarterly J. of Operations Research     Hybrid Journal   (Followers: 10, SJR: 0.825, CiteScore: 1)
AAPS J.     Hybrid Journal   (Followers: 22, SJR: 1.118, CiteScore: 4)
AAPS PharmSciTech     Hybrid Journal   (Followers: 7, SJR: 0.752, CiteScore: 3)
Abdominal Imaging     Hybrid Journal   (Followers: 15, SJR: 0.866, CiteScore: 2)
Abhandlungen aus dem Mathematischen Seminar der Universitat Hamburg     Hybrid Journal   (Followers: 4, SJR: 0.439, CiteScore: 0)
Academic Psychiatry     Full-text available via subscription   (Followers: 26, SJR: 0.53, CiteScore: 1)
Academic Questions     Hybrid Journal   (Followers: 8, SJR: 0.106, CiteScore: 0)
Accreditation and Quality Assurance: J. for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 27, SJR: 0.316, CiteScore: 1)
Acoustical Physics     Hybrid Journal   (Followers: 11, SJR: 0.359, CiteScore: 1)
Acoustics Australia     Hybrid Journal   (SJR: 0.232, CiteScore: 1)
Acta Analytica     Hybrid Journal   (Followers: 7, SJR: 0.367, CiteScore: 0)
Acta Applicandae Mathematicae     Hybrid Journal   (Followers: 1, SJR: 0.675, CiteScore: 1)
Acta Biotheoretica     Hybrid Journal   (Followers: 4, SJR: 0.284, CiteScore: 1)
Acta Diabetologica     Hybrid Journal   (Followers: 18, SJR: 1.587, CiteScore: 3)
Acta Endoscopica     Hybrid Journal   (Followers: 1)
acta ethologica     Hybrid Journal   (Followers: 4, SJR: 0.769, CiteScore: 1)
Acta Geochimica     Hybrid Journal   (Followers: 7, SJR: 0.24, CiteScore: 1)
Acta Geodaetica et Geophysica     Hybrid Journal   (Followers: 2, SJR: 0.305, CiteScore: 1)
Acta Geophysica     Hybrid Journal   (Followers: 10, SJR: 0.312, CiteScore: 1)
Acta Geotechnica     Hybrid Journal   (Followers: 7, SJR: 1.588, CiteScore: 3)
Acta Informatica     Hybrid Journal   (Followers: 5, SJR: 0.517, CiteScore: 1)
Acta Mathematica     Hybrid Journal   (Followers: 12, SJR: 7.066, CiteScore: 3)
Acta Mathematica Hungarica     Hybrid Journal   (Followers: 2, SJR: 0.452, CiteScore: 1)
Acta Mathematica Sinica, English Series     Hybrid Journal   (Followers: 6, SJR: 0.379, CiteScore: 1)
Acta Mathematica Vietnamica     Hybrid Journal   (SJR: 0.27, CiteScore: 0)
Acta Mathematicae Applicatae Sinica, English Series     Hybrid Journal   (SJR: 0.208, CiteScore: 0)
Acta Mechanica     Hybrid Journal   (Followers: 21, SJR: 1.04, CiteScore: 2)
Acta Mechanica Sinica     Hybrid Journal   (Followers: 5, SJR: 0.607, CiteScore: 2)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 7, SJR: 0.576, CiteScore: 2)
Acta Meteorologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.638, CiteScore: 1)
Acta Neurochirurgica     Hybrid Journal   (Followers: 6, SJR: 0.822, CiteScore: 2)
Acta Neurologica Belgica     Hybrid Journal   (Followers: 1, SJR: 0.376, CiteScore: 1)
Acta Neuropathologica     Hybrid Journal   (Followers: 4, SJR: 7.589, CiteScore: 12)
Acta Oceanologica Sinica     Hybrid Journal   (Followers: 3, SJR: 0.334, CiteScore: 1)
Acta Physiologiae Plantarum     Hybrid Journal   (Followers: 2, SJR: 0.574, CiteScore: 2)
Acta Politica     Hybrid Journal   (Followers: 15, SJR: 0.605, CiteScore: 1)
Activitas Nervosa Superior     Hybrid Journal   (SJR: 0.147, CiteScore: 0)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 8, SJR: 0.103, CiteScore: 0)
ADHD Attention Deficit and Hyperactivity Disorders     Hybrid Journal   (Followers: 23, SJR: 0.72, CiteScore: 2)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 9)
Administration and Policy in Mental Health and Mental Health Services Research     Partially Free   (Followers: 16, SJR: 1.005, CiteScore: 2)
Adsorption     Hybrid Journal   (Followers: 4, SJR: 0.703, CiteScore: 2)
Advances in Applied Clifford Algebras     Hybrid Journal   (Followers: 4, SJR: 0.698, CiteScore: 1)
Advances in Atmospheric Sciences     Hybrid Journal   (Followers: 37, SJR: 0.956, CiteScore: 2)
Advances in Computational Mathematics     Hybrid Journal   (Followers: 19, SJR: 0.812, CiteScore: 1)
Advances in Contraception     Hybrid Journal   (Followers: 3)
Advances in Data Analysis and Classification     Hybrid Journal   (Followers: 55, SJR: 1.09, CiteScore: 1)
Advances in Gerontology     Partially Free   (Followers: 8, SJR: 0.144, CiteScore: 0)
Advances in Health Sciences Education     Hybrid Journal   (Followers: 29, SJR: 1.64, CiteScore: 2)
Advances in Manufacturing     Hybrid Journal   (Followers: 4, SJR: 0.475, CiteScore: 2)
Advances in Polymer Science     Hybrid Journal   (Followers: 45, SJR: 1.04, CiteScore: 3)
Advances in Therapy     Hybrid Journal   (Followers: 5, SJR: 1.075, CiteScore: 3)
Aegean Review of the Law of the Sea and Maritime Law     Hybrid Journal   (Followers: 6)
Aequationes Mathematicae     Hybrid Journal   (Followers: 2, SJR: 0.517, CiteScore: 1)
Aerobiologia     Hybrid Journal   (Followers: 3, SJR: 0.673, CiteScore: 2)
Aesthetic Plastic Surgery     Hybrid Journal   (Followers: 9, SJR: 0.825, CiteScore: 1)
African Archaeological Review     Hybrid Journal   (Followers: 18, SJR: 0.862, CiteScore: 1)
Afrika Matematika     Hybrid Journal   (Followers: 1, SJR: 0.235, CiteScore: 0)
AGE     Hybrid Journal   (Followers: 7)
Ageing Intl.     Hybrid Journal   (Followers: 7, SJR: 0.39, CiteScore: 1)
Aggiornamenti CIO     Hybrid Journal   (Followers: 1)
Aging Clinical and Experimental Research     Hybrid Journal   (Followers: 3, SJR: 0.67, CiteScore: 2)
Agricultural Research     Hybrid Journal   (Followers: 6, SJR: 0.276, CiteScore: 1)
Agriculture and Human Values     Hybrid Journal   (Followers: 14, SJR: 1.173, CiteScore: 3)
Agroforestry Systems     Hybrid Journal   (Followers: 20, SJR: 0.663, CiteScore: 1)
Agronomy for Sustainable Development     Hybrid Journal   (Followers: 12, SJR: 1.864, CiteScore: 6)
AI & Society     Hybrid Journal   (Followers: 8, SJR: 0.227, CiteScore: 1)
AIDS and Behavior     Hybrid Journal   (Followers: 14, SJR: 1.792, CiteScore: 3)
Air Quality, Atmosphere & Health     Hybrid Journal   (Followers: 4, SJR: 0.862, CiteScore: 3)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Algebra and Logic     Hybrid Journal   (Followers: 6, SJR: 0.531, CiteScore: 0)
Algebra Universalis     Hybrid Journal   (Followers: 2, SJR: 0.583, CiteScore: 1)
Algebras and Representation Theory     Hybrid Journal   (Followers: 1, SJR: 1.095, CiteScore: 1)
Algorithmica     Hybrid Journal   (Followers: 9, SJR: 0.56, CiteScore: 1)
Allergo J.     Full-text available via subscription   (Followers: 1, SJR: 0.234, CiteScore: 0)
Allergo J. Intl.     Hybrid Journal   (Followers: 2)
Alpine Botany     Hybrid Journal   (Followers: 5, SJR: 1.11, CiteScore: 3)
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 3)
AMBIO     Hybrid Journal   (Followers: 10, SJR: 1.569, CiteScore: 4)
American J. of Cardiovascular Drugs     Hybrid Journal   (Followers: 16, SJR: 0.951, CiteScore: 3)
American J. of Community Psychology     Hybrid Journal   (Followers: 29, SJR: 1.329, CiteScore: 2)
American J. of Criminal Justice     Hybrid Journal   (Followers: 8, SJR: 0.772, CiteScore: 1)
American J. of Cultural Sociology     Hybrid Journal   (Followers: 16, SJR: 0.46, CiteScore: 1)
American J. of Dance Therapy     Hybrid Journal   (Followers: 4, SJR: 0.181, CiteScore: 0)
American J. of Potato Research     Hybrid Journal   (Followers: 2, SJR: 0.611, CiteScore: 1)
American J. of Psychoanalysis     Hybrid Journal   (Followers: 21, SJR: 0.314, CiteScore: 0)
American Sociologist     Hybrid Journal   (Followers: 13, SJR: 0.35, CiteScore: 0)
Amino Acids     Hybrid Journal   (Followers: 8, SJR: 1.135, CiteScore: 3)
AMS Review     Partially Free   (Followers: 4)
Analog Integrated Circuits and Signal Processing     Hybrid Journal   (Followers: 7, SJR: 0.211, CiteScore: 1)
Analysis and Mathematical Physics     Hybrid Journal   (Followers: 5, SJR: 0.536, CiteScore: 1)
Analysis in Theory and Applications     Hybrid Journal   (Followers: 1)
Analysis of Verbal Behavior     Hybrid Journal   (Followers: 5)
Analytical and Bioanalytical Chemistry     Hybrid Journal   (Followers: 31, SJR: 0.978, CiteScore: 3)
Anatomical Science Intl.     Hybrid Journal   (Followers: 3, SJR: 0.367, CiteScore: 1)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 3, SJR: 2.177, CiteScore: 5)
Animal Cognition     Hybrid Journal   (Followers: 19, SJR: 1.389, CiteScore: 3)
Annales françaises de médecine d'urgence     Hybrid Journal   (Followers: 1, SJR: 0.192, CiteScore: 0)
Annales Henri Poincaré     Hybrid Journal   (Followers: 3, SJR: 1.097, CiteScore: 2)
Annales mathématiques du Québec     Hybrid Journal   (Followers: 4, SJR: 0.438, CiteScore: 0)
Annali dell'Universita di Ferrara     Hybrid Journal   (SJR: 0.429, CiteScore: 0)
Annali di Matematica Pura ed Applicata     Hybrid Journal   (Followers: 1, SJR: 1.197, CiteScore: 1)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18, SJR: 1.042, CiteScore: 3)
Annals of Combinatorics     Hybrid Journal   (Followers: 4, SJR: 0.932, CiteScore: 1)
Annals of Data Science     Hybrid Journal   (Followers: 12)
Annals of Dyslexia     Hybrid Journal   (Followers: 10, SJR: 0.85, CiteScore: 2)
Annals of Finance     Hybrid Journal   (Followers: 30, SJR: 0.579, CiteScore: 1)
Annals of Forest Science     Hybrid Journal   (Followers: 7, SJR: 0.986, CiteScore: 2)
Annals of Global Analysis and Geometry     Hybrid Journal   (Followers: 1, SJR: 1.228, CiteScore: 1)
Annals of Hematology     Hybrid Journal   (Followers: 15, SJR: 1.043, CiteScore: 2)
Annals of Mathematics and Artificial Intelligence     Hybrid Journal   (Followers: 13, SJR: 0.413, CiteScore: 1)
Annals of Microbiology     Hybrid Journal   (Followers: 11, SJR: 0.479, CiteScore: 2)
Annals of Nuclear Medicine     Hybrid Journal   (Followers: 4, SJR: 0.687, CiteScore: 2)
Annals of Operations Research     Hybrid Journal   (Followers: 10, SJR: 0.943, CiteScore: 2)
Annals of Ophthalmology     Hybrid Journal   (Followers: 12)
Annals of Regional Science     Hybrid Journal   (Followers: 7, SJR: 0.614, CiteScore: 1)
Annals of Software Engineering     Hybrid Journal   (Followers: 13)
Annals of Solid and Structural Mechanics     Hybrid Journal   (Followers: 9, SJR: 0.239, CiteScore: 1)
Annals of Surgical Oncology     Hybrid Journal   (Followers: 13, SJR: 1.986, CiteScore: 4)
Annals of Telecommunications     Hybrid Journal   (Followers: 9, SJR: 0.223, CiteScore: 1)
Annals of the Institute of Statistical Mathematics     Hybrid Journal   (Followers: 1, SJR: 1.495, CiteScore: 1)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 5, SJR: 0.834, CiteScore: 2)
Apidologie     Hybrid Journal   (Followers: 4, SJR: 1.22, CiteScore: 3)
APOPTOSIS     Hybrid Journal   (Followers: 8, SJR: 1.424, CiteScore: 4)
Applicable Algebra in Engineering, Communication and Computing     Hybrid Journal   (Followers: 2, SJR: 0.294, CiteScore: 1)
Applications of Mathematics     Hybrid Journal   (Followers: 2, SJR: 0.602, CiteScore: 1)
Applied Biochemistry and Biotechnology     Hybrid Journal   (Followers: 43, SJR: 0.571, CiteScore: 2)
Applied Biochemistry and Microbiology     Hybrid Journal   (Followers: 17, SJR: 0.21, CiteScore: 1)
Applied Cancer Research     Open Access  
Applied Categorical Structures     Hybrid Journal   (Followers: 2, SJR: 0.49, CiteScore: 0)
Applied Composite Materials     Hybrid Journal   (Followers: 49, SJR: 0.58, CiteScore: 2)
Applied Entomology and Zoology     Partially Free   (Followers: 4, SJR: 0.422, CiteScore: 1)
Applied Geomatics     Hybrid Journal   (Followers: 3, SJR: 0.733, CiteScore: 3)
Applied Geophysics     Hybrid Journal   (Followers: 8, SJR: 0.488, CiteScore: 1)
Applied Intelligence     Hybrid Journal   (Followers: 12, SJR: 0.6, CiteScore: 2)
Applied Magnetic Resonance     Hybrid Journal   (Followers: 4, SJR: 0.319, CiteScore: 1)
Applied Mathematics & Optimization     Hybrid Journal   (Followers: 9, SJR: 0.886, CiteScore: 1)
Applied Mathematics - A J. of Chinese Universities     Hybrid Journal   (SJR: 0.17, CiteScore: 0)
Applied Mathematics and Mechanics     Hybrid Journal   (Followers: 5, SJR: 0.461, CiteScore: 1)
Applied Microbiology and Biotechnology     Hybrid Journal   (Followers: 65, SJR: 1.182, CiteScore: 4)
Applied Physics A     Hybrid Journal   (Followers: 10, SJR: 0.481, CiteScore: 2)
Applied Physics B: Lasers and Optics     Hybrid Journal   (Followers: 24, SJR: 0.74, CiteScore: 2)
Applied Psychophysiology and Biofeedback     Hybrid Journal   (Followers: 8, SJR: 0.519, CiteScore: 2)
Applied Research in Quality of Life     Hybrid Journal   (Followers: 12, SJR: 0.316, CiteScore: 1)
Applied Solar Energy     Hybrid Journal   (Followers: 18, SJR: 0.225, CiteScore: 0)
Applied Spatial Analysis and Policy     Hybrid Journal   (Followers: 5, SJR: 0.542, CiteScore: 1)
Aquaculture Intl.     Hybrid Journal   (Followers: 24, SJR: 0.591, CiteScore: 2)
Aquarium Sciences and Conservation     Hybrid Journal   (Followers: 2)
Aquatic Ecology     Hybrid Journal   (Followers: 34, SJR: 0.656, CiteScore: 2)
Aquatic Geochemistry     Hybrid Journal   (Followers: 4, SJR: 0.591, CiteScore: 1)
Aquatic Sciences     Hybrid Journal   (Followers: 13, SJR: 1.109, CiteScore: 3)
Arabian J. for Science and Engineering     Hybrid Journal   (Followers: 5, SJR: 0.303, CiteScore: 1)
Arabian J. of Geosciences     Hybrid Journal   (Followers: 2, SJR: 0.319, CiteScore: 1)
Archaeological and Anthropological Sciences     Hybrid Journal   (Followers: 21, SJR: 1.052, CiteScore: 2)
Archaeologies     Hybrid Journal   (Followers: 12, SJR: 0.224, CiteScore: 0)
Archiv der Mathematik     Hybrid Journal   (Followers: 1, SJR: 0.725, CiteScore: 1)
Archival Science     Hybrid Journal   (Followers: 62, SJR: 0.745, CiteScore: 2)
Archive for History of Exact Sciences     Hybrid Journal   (Followers: 7, SJR: 0.186, CiteScore: 1)
Archive for Mathematical Logic     Hybrid Journal   (Followers: 3, SJR: 0.909, CiteScore: 1)
Archive for Rational Mechanics and Analysis     Hybrid Journal   (SJR: 3.93, CiteScore: 3)
Archive of Applied Mechanics     Hybrid Journal   (Followers: 5, SJR: 0.79, CiteScore: 2)
Archives and Museum Informatics     Hybrid Journal   (Followers: 143, SJR: 0.101, CiteScore: 0)
Archives of Computational Methods in Engineering     Hybrid Journal   (Followers: 5, SJR: 1.41, CiteScore: 5)
Archives of Dermatological Research     Hybrid Journal   (Followers: 7, SJR: 1.006, CiteScore: 2)
Archives of Environmental Contamination and Toxicology     Hybrid Journal   (Followers: 14, SJR: 0.773, CiteScore: 2)
Archives of Gynecology and Obstetrics     Hybrid Journal   (Followers: 16, SJR: 0.956, CiteScore: 2)
Archives of Microbiology     Hybrid Journal   (Followers: 8, SJR: 0.644, CiteScore: 2)
Archives of Orthopaedic and Trauma Surgery     Hybrid Journal   (Followers: 8, SJR: 1.146, CiteScore: 2)
Archives of Osteoporosis     Hybrid Journal   (Followers: 2, SJR: 0.71, CiteScore: 2)
Archives of Sexual Behavior     Hybrid Journal   (Followers: 10, SJR: 1.493, CiteScore: 3)
Archives of Toxicology     Hybrid Journal   (Followers: 17, SJR: 1.541, CiteScore: 5)
Archives of Virology     Hybrid Journal   (Followers: 5, SJR: 0.973, CiteScore: 2)
Archives of Women's Mental Health     Hybrid Journal   (Followers: 14, SJR: 1.274, CiteScore: 3)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2, SJR: 0.946, CiteScore: 3)
ArgoSpine News & J.     Hybrid Journal  
Argumentation     Hybrid Journal   (Followers: 6, SJR: 0.349, CiteScore: 1)
Arid Ecosystems     Hybrid Journal   (Followers: 2, SJR: 0.2, CiteScore: 0)
Arkiv för Matematik     Hybrid Journal   (Followers: 1, SJR: 0.766, CiteScore: 1)
Arnold Mathematical J.     Hybrid Journal   (Followers: 1, SJR: 0.355, CiteScore: 0)
Arthropod-Plant Interactions     Hybrid Journal   (Followers: 2, SJR: 0.839, CiteScore: 2)
Arthroskopie     Hybrid Journal   (Followers: 1, SJR: 0.131, CiteScore: 0)
Artificial Intelligence and Law     Hybrid Journal   (Followers: 11, SJR: 0.937, CiteScore: 2)
Artificial Intelligence Review     Hybrid Journal   (Followers: 16, SJR: 0.833, CiteScore: 4)
Artificial Life and Robotics     Hybrid Journal   (Followers: 9, SJR: 0.226, CiteScore: 0)
Asia Europe J.     Hybrid Journal   (Followers: 5, SJR: 0.504, CiteScore: 1)
Asia Pacific Education Review     Hybrid Journal   (Followers: 12, SJR: 0.479, CiteScore: 1)
Asia Pacific J. of Management     Hybrid Journal   (Followers: 16, SJR: 1.185, CiteScore: 2)
Asia-Pacific Education Researcher     Hybrid Journal   (Followers: 12, SJR: 0.353, CiteScore: 1)
Asia-Pacific Financial Markets     Hybrid Journal   (Followers: 2, SJR: 0.187, CiteScore: 0)
Asia-Pacific J. of Atmospheric Sciences     Hybrid Journal   (Followers: 19, SJR: 0.855, CiteScore: 1)
Asian Business & Management     Hybrid Journal   (Followers: 9, SJR: 0.378, CiteScore: 1)
Asian J. of Business Ethics     Hybrid Journal   (Followers: 9)
Asian J. of Criminology     Hybrid Journal   (Followers: 6, SJR: 0.543, CiteScore: 1)
AStA Advances in Statistical Analysis     Hybrid Journal   (Followers: 3, SJR: 0.548, CiteScore: 1)
AStA Wirtschafts- und Sozialstatistisches Archiv     Hybrid Journal   (Followers: 5, SJR: 0.183, CiteScore: 0)
ästhetische dermatologie & kosmetologie     Full-text available via subscription  

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Journal Cover
Zeitschrift fur Rheumatologie
Journal Prestige (SJR): 0.252
Citation Impact (citeScore): 1
Number of Followers: 11  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0340-1855 - ISSN (Online) 1435-1250
Published by Springer-Verlag Homepage  [2351 journals]
  • Kinderrheumatologie
    • Pages: 646 - 648
      PubDate: 2018-10-01
      DOI: 10.1007/s00393-018-0508-4
      Issue No: Vol. 77, No. 8 (2018)
  • Adoleszentenrheumatologie
    • Authors: H.-I. Huppertz; P. Villiger
      Pages: 649 - 650
      PubDate: 2018-10-01
      DOI: 10.1007/s00393-018-0520-8
      Issue No: Vol. 77, No. 8 (2018)
  • Transition in der Kinderrheumatologie – Erfahrungen aus dem
           Kinderrheumazentrum Sankt Augustin
    • Authors: A. Klein; F. Olbert; S. Wintrich; V. Lutz-Wiegers; G. Horneff
      Pages: 677 - 684
      Abstract: Zusammenfassung Hintergrund Transition ist eine gemeinschaftliche Leistung der jungen Patienten, ihrer Familien und der betreuenden pädiatrischen und internistischer Rheumatologen. Die Qualität des eigenen Transitionsprozesses bei Patienten mit rheumatischen Erkrankungen wurde anhand eines standardisierten Fragebogens retrospektiv untersucht. Die Patienten wurden nach Möglichkeit über persönliche Kontaktaufnahme an einen Erwachsenenrheumatologen vermittelt. Methode Einschlusskriterien waren: Diagnose einer chronisch entzündlich rheumatischen Erkrankung, kontinuierliche Versorgungsdauer am Zentrum >2 Jahre sowie ≥2 Vorstellungen im Alter von 17 bis 18 Jahren. Es erfolgte ein Telefoninterview mit einem strukturierten Fragebogen zur Art der Versorgung, Medikation, Diagnose und Zufriedenheit mit Versorgung und Transitionsvorgang. Ergebnisse Es wurden 62 Patienten eingeschlossen, hiervon hatten 50 Patienten (81 %) eine juvenile idiopathische Arthritis (JIA). Eine regelmäßige Weiterbehandlung fand bei 40 (65 %) bei einem internistischen Rheumatologen statt. Gründe für einen Abbruch der Versorgung waren v. a. Beschwerdefreiheit, fehlende Zeit und Non-Compliance. Vor/nach Transition erhielten 15/9 Patienten ein konventionelles „disease-modifying antirheumatic drug“ (DMARD) und 27/27 ein Biologikum. Die subjektive Beurteilung der Versorgung in der Kinderrheumatologie war (MW ± SD) 9,3 ± 1,05, bei internistischen Rheumatologen 7,6 ± 1,1 und des Transitionsprozesses 7,7 ± 2,1. Probleme sahen die Patienten in mangelnder Zeit des Arztes und langen Wartezeiten auf Termine. Diskussion Eine individuelle Vermittlung der Patienten aus der kinderfachärztlichen Betreuung an einen internistischen Rheumatologen war nach der vorliegenden Erhebung mit hoher Zufriedenheit verbunden. Diagnosewechsel oder ein unerwartetes Beenden der rheumatologischen Therapie war nicht erkennbar.
      PubDate: 2018-10-01
      DOI: 10.1007/s00393-018-0511-9
      Issue No: Vol. 77, No. 8 (2018)
  • Neue Unterstützungsangebote für die Betreuung junger Rheumatiker
    • Authors: S. Schalm; M. Niewerth; K. Minden
      Pages: 685 - 693
      Abstract: Zusammenfassung Der Prozess des Überganges von der pädiatrischen in die internistisch rheumatologische Versorgung (Transition) ist für Patienten und medizinisches Personal eine Herausforderung. Jeder zweite im Kindes- oder Jugendalter erkrankte Rheumapatient weist im Erwachsenenalter noch eine behandlungsbedürftige Erkrankung auf. Unverändert bricht etwa ein Drittel der jungen Rheumatiker in Deutschland auf dem Weg in die Erwachsenenmedizin die regelmäßige fachspezifische Versorgung ab. Um die Transition zu verbessern, wurden in Deutschland unterstützende Angebote entwickelt, die in diesem Beitrag dargestellt werden.
      PubDate: 2018-10-01
      DOI: 10.1007/s00393-018-0547-x
      Issue No: Vol. 77, No. 8 (2018)
  • Rheuma beim Jugendlichen
    • Authors: Sabine Adler
      Pages: 694 - 702
      Abstract: Zusammenfassung Zwischen Kindheit und Erwachsensein gibt es eine oft unangenehme Zeit des Erwachsenwerdens. Diese Phase stellt gerade für Jugendliche und Heranwachsende, die an einer chronischen rheumatischen Erkrankung leiden, häufig eine große Herausforderung auf physischer, psychischer und sozialer Ebene dar. Die medizinische und menschliche Begleitung kann sich entsprechend vielschichtig gestalten. Vor diesem Hintergrund hat sich der Einsatz eines interprofessionellen Teams im Sinne einer spezialisierten Transitionssprechstunde bewährt. Im Inselspital in Bern arbeiten Kinder- und Erwachsenenrheumatologen gemeinsam in der Sprechstunde, flankiert von einem Team aus Pflegern, Ergotherapeuten, Physiotherapeuten, Sozialmedizinern und Psychologen, das auf individuell notwendiger Basis hinzugezogen wird. Allen an der Betreuung dieser jungen Patienten Beteiligten sollte bewusst sein, dass eine in der Kindheit begonnene rheumatische Erkrankung meist anders verläuft, als wenn sie erst im Erwachsenenalter beginnt.
      PubDate: 2018-10-01
      DOI: 10.1007/s00393-018-0530-6
      Issue No: Vol. 77, No. 8 (2018)
  • Clinical and ultrasonographic enthesopathy in inflammatory rheumatic
    • Authors: Ekrem Süleyman; Kemal Nas; Halil Harman; Nedim Kaban
      Pages: 719 - 726
      Abstract: Aim We aimed at investigating the ultrasonographic (US) and clinical prevalence of enthesopathy in patients with rheumatoid arthritis (RA), and axial spondyloarthropathy (SpA), as well as the correlation between this condition and disease activity, along with the quality of life. Methods Included in the study were 30 axial SpA, 21 patients with RA, and 25 healthy cases. Bath Anklylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Quality of Life (ASQoL), Disease activity index  28 (DAS28), and Health Assessment Questionnaire (HAQ) were used for clinical evaluation, and enthesal pain was evaluated by VAS, whereas enthesitis US evaluation was performed by using the MAdrid Sonographic Enthesitis Index (MASEI). A total of 152 knees, ankles, and elbow regions of all patients and controls were examined by US. Results Total scores of physical examination of enthesitis were 1.97 ± 2.68 in axial SpA, 2.43 ± 1.80 in RA, and 0.23 ± 0.12 in the control groups. No statistically significant difference was identified in the enthesitis examination between axial SpA and RA groups (p = 0.123). According to the MASEI, no significant difference was observed in quadriceps tendon enthesitis or in distal patellar ligament enthesitis between axial SpA and RA groups (MASEI 3, 4, 5: p = 0.993, p = 0.124, p = 0.652). Aside from those points, axial SpA patients had statistically higher enthesitis scores at all MASEI enthesitis points (p < 0.05). In the axial SpA group, a significant and positive correlation was identified between BASDAI scores and total scores of enthesitis physical examination and MASEI total scores (r = 0.739, p = 0.0001, r = 0.516, p = 0.002). A moderately significant correlation was identified between ASQoL total scores and MASEI total scores (r = 0.466, p = 0.006), but not between the HAQ total scores and MASEI total scores (r = 0.213, p = 0.065). Conclusions Compared to RA, US and clinical examination of enthesitis in patients with axial SpA should focus on the calcaneal enthesitis region. In axial SpA, ultrasonographic enthesitis is associated with impaired quality of life.
      PubDate: 2018-10-01
      DOI: 10.1007/s00393-017-0405-2
      Issue No: Vol. 77, No. 8 (2018)
  • Myositisspezifische Antikörper bei juveniler Dermatomyositis
    • Authors: K. Eising; J. Peitz; N. Unterwalder; C. Meisel; G. Horneff
      Pages: 735 - 740
      Abstract: Zusammenfassung Hintergrund Die juvenile Dermatomyositis (jDM) ist eine seltene Autoimmunerkrankung, klinisch charakterisiert durch typische Hautveränderungen und Muskelschwäche. Bei einigen Patienten können myositisassoziierte (MAA) oder myositisspezifische Antikörper (MSA) nachgewiesen werden. Diese sind bedeutsam für Krankheitsspektrum und Prognose. Methodik Bei 12 aktuell betreuten jDM-Patienten des Rheumazentrums Sankt Augustin erfolgte eine Untersuchung auf MAA und MSA mittels eines Line-Immunoassays. Ergebnisse Bei 10 von 12 Patienten konnten insgesamt 15 Myositisantikörper nachgewiesen werden. Je 3 Patienten hatten Mi2-, SRP- oder NXP2-Antikörper, 2 hatten TIF-1γ-Antikörper und je 1 Patient Jo1- oder Mi2β-Antikörper. Zwei Patienten hatten zusätzlich PM-Scl-Antikörper. Bei den 10 Patienten mit nachgewiesenen Antikörpern zeigte sich eine gute Phänotyp-Serotyp-Korrelation mit Abweichung von den in der Literatur beschriebenen Phänotypen bei 3 Patienten. Schlussfolgerung Der häufige Nachweis von spezifischen Antikörpern und die gute Korrelation mit den in der Literatur beschriebenen Phänotypen zeigen, dass die Bestimmung von MSA ein wichtiges diagnostisches Hilfsmittel ist, um Verlauf, Komplikationen und Outcome abzuschätzen und frühzeitig eine adäquate Therapie einzuleiten.
      PubDate: 2018-10-01
      DOI: 10.1007/s00393-017-0415-0
      Issue No: Vol. 77, No. 8 (2018)
  • Eine seltene Manifestation einer entzündlich rheumatischen
    • Authors: Ole Hudowenz; Malte Knabe; Kirsten de Groot
      Pages: 749 - 752
      Abstract: Zusammenfassung Die Granulomatose mit Polyangiitis (GPA) gehört zu den ANCA(Anti-Neutrophile cytoplasmatische Antikörper)-assoziierten Kleingefäßvaskulitiden (AAV) und befällt typischerweise den Respirationstrakt und die Nieren. Diese Kasuistik beschreibt einen 46-jährigen GPA-Patienten mit einem selteneren Organbefallsmuster: Neben einer foudroyant verlaufenden Tetraparese zeigte sich eine schwere ulzerierende Kolitis. Die frühzeitige Diagnose und die Abgrenzung zu einem septischen Geschehen sind essenziell.
      PubDate: 2018-10-01
      DOI: 10.1007/s00393-018-0501-y
      Issue No: Vol. 77, No. 8 (2018)
  • Mitteilungen der DGRh
    • Pages: 753 - 756
      PubDate: 2018-10-01
      DOI: 10.1007/s00393-018-0544-0
      Issue No: Vol. 77, No. 8 (2018)
  • Mitteilungen der DRL
    • Pages: 757 - 758
      PubDate: 2018-10-01
      DOI: 10.1007/s00393-018-0548-9
      Issue No: Vol. 77, No. 8 (2018)
  • Kurzübersicht der Diagnostik des Pyoderma gangraenosum
    • Authors: Joachim Dissemond
      Abstract: Zusammenfassung Die Diagnose Pyoderma gangraenosum musste bislang als Ausschlussdiagnose gestellt werden. Aus diesem Grund wurde in den letzten Jahren wiederholt versucht, Diagnosescores zu entwickeln. Hierbei wurden meist die typischen klinischen und anamnestischen Aspekte berücksichtigt und die relevanten Differenzialdiagnosen ausgeschlossen. Mit dem PARACELSUS-Score wurde nun erstmalig ein evaluierter Diagnosescore vorgestellt. Hauptkriterien der Diagnostik sind in diesem Score ein rasch progredienter Krankheitsverlauf, Ausschluss relevanter Differenzialdiagnosen und ein erythematös, livider Randsaum. Wenn diese Kriterien vorhanden sind oder waren, werden jeweils 3 Punkte vergeben. Nebenkriterien mit einem Punktwert von jeweils 2 sind ein Ansprechen auf eine immunsupprimierende Therapie, eine charakteristische, bizarre Wundform, extreme Schmerzen von >4 auf der visuellen Analogskala und ein lokales Pathergiephänomen. Zusatzkriterien, die mit jeweils 1 Punkt bewertet werden, sind eine suppurative Inflammation in der Histopathologie, unterminierte, tiefe Wundränder und die Assoziation relevanter Systemerkrankungen. Ein additiver Punktwert von ≥10 macht das Vorliegen eines Pyoderma gangraenosum sehr wahrscheinlich. Der neu entwickelte und evaluierte PARACELSUS-Score ist ein einfach anzuwendendes klinisches Instrument, um die Sicherung der Diagnose Pyoderma gangraenosum zu objektivieren.
      PubDate: 2018-10-16
      DOI: 10.1007/s00393-018-0553-z
  • Assessment of hand function and disability in fibromyalgia
    • Authors: G. Devrimsel; A. K. Turkyilmaz; M. S. Beyazal; M. Karkucak
      Abstract: Objective Fibromyalgia, a potentially debilitating chronic pain syndrome, is a chronic disease. We aimed to compare the hand function of fibromyalgia (FM) patients and healthy individuals and to demonstrate the relationship between hand disability and FM. Patients and methods The study was consisted of 40 female patients with FM and 30 healthy controls. All participants were evaluated for pain threshold measurements, handgrip strength, and pinch strength. Functional states, hand disability, and hand skills and coordination were evaluated using the Fibromyalgia Impact Questionnaire (FIQ) form, the Disability of Arm–Shoulder–Hand (DASH) questionnaire and the Purdue Pegboard Test, respectively. Results Handgrip strength values, DASH score, lateral pinch strength test, Pegboard placement time, and Pegboard collection time of the patient group were significantly lower than those of the control group (all p < 0.05). A negative correlation was found between FIQ score and handgrip strength, two-point pinch strength test, three-point pinch strength test, and lateral pinch strength test in patients with moderate FM (all p < 0.05). Furthermore, a correlation was observed between DASH score and handgrip strength, lateral pinch strength test, Purdue Pegboard placement time, and Purdue Pegboard collection time in patients with moderate FM (all p < 0.05). Conclusions Our results show that hand function was decreased in patients with FM compared to healthy controls and decreasing hand function was influenced by FIQ score. As a result, the evaluation of hand function should be taken into consideration in the management of FM.
      PubDate: 2018-10-15
      DOI: 10.1007/s00393-018-0558-7
  • Aortic aneurysm and dissection in systemic lupus erythematosus
    • Authors: Shi-Min Yuan
      Abstract: Aortic aneurysm and dissection are rare complications of systemic lupus erythematosus (SLE). The incidence, etiology, risk factors, and outcomes of this entity were largely unknown. The study materials were based on the publications of aortic aneurysm or dissection due to SLE published between 2000 and 2017. A total of 36 articles reporting a single case or case series involving 40 patients were collected. The patients showed an absolute female dominance at a mean aneurysm age of 44.6 years. Steroid use was 13.3 ± 9.4 years prior to admission for management of aortic aneurysm or dissection. Aortic aneurysm occurred more commonly in abdominal than other segments of the aorta, whereas aortic dissection did not show any location predilection. Patients with open aortic operations showed a higher mortality rate than other groups; however, no statistical significance was reached. Interventional therapy was minimally invasive, but postinterventional endoleaks were a concerning problem. SLE patients had significant risks for developing aortic aneurysm and dissection. Hypertension, long-term steroid use, and aortic pathological changes related to SLE seemed to be predominant risk factors for the occurrence of aortic aneurysm and dissection. Upon diagnosis, a surgical, interventional, or hybrid treatment should be performed to prevent severe sequelae and sudden deaths.
      PubDate: 2018-10-15
      DOI: 10.1007/s00393-018-0555-x
  • Lücken im regulatorischen T‑Zell-Schutzschild erzeugen
    • Authors: P. Bacher
      PubDate: 2018-10-09
      DOI: 10.1007/s00393-018-0554-y
  • Mitochondrial disorder mimicking rheumatoid disease
    • Authors: Josef Finsterer; Madleine Melichart-Kotig; Adelheid Woehrer
      Abstract: Objective Mitochondrial disorders (MIDs) may manifest phenotypically with a plethora of clinical features, but polyarthralgia and cutaneous lesions are still infrequently reported and recognized as phenotypic manifestations of a MID. Case report The patient is a 27-year-old Caucasian female with a history of preterm birth, symptomatic myopathy, and polyarthralgia since infancy, followed by multiple endocrinopathies including pituitary insufficiency, cardiac conduction defects, nephrolithiasis, aseptic chronic pancreatitis and sialadenitis, anemia, hyperlipidemia, and dysmorphic features. The patient reported to have profited from hydrocortisone and long-term chloroquine, but hardly from long-term immunosuppression with various immunosuppressants. The diagnosis MID was established upon the multiorgan nature of the disease, presence of core clinical features of a MID, and a muscle biopsy indicative of a mitochondrial defect. The family history was positive for mitochondrial features in the mother and grandmother from the mother’s side. Conclusion Seronegative and non-destructive polyarthralgia and unexplained cutaneous features mimicking cutaneous lupus should be considered as a phenotypic feature of a multisystem MID (mitochondrial multiorgan disorder syndrome, MIMODS). Mitochondrial metabolic defects may trigger secondary immune reactions. Core clinical features of a non-specific MID with infantile onset include symptomatic myopathy, endocrine abnormalities, cardiac conduction defects, dysmorphism, hyperlipidemia, anemia, and nephrolithiasis.
      PubDate: 2018-10-05
      DOI: 10.1007/s00393-018-0551-1
  • Pathogenese des systemischen Lupus erythematodes
    • Authors: S. Finzel; S. Schaffer; M. Rizzi; R. E. Voll
      Abstract: Zusammenfassung Die Krankheitsursachen und Störungen des Immunsystems, die zur Entstehung des systemischen Lupus erythematodes (SLE) beitragen, sind bisher nur teilweise verstanden. Wir wissen aber, dass es verschiedene Mechanismen gibt, die zur Entwicklung eines SLE führen können. Der Entstehung der Erkrankung liegt eine genetische Prädisposition zugrunde, jedoch kommt es erst durch Einwirkung von Umwelteinflüssen (z. B. Sonnenbrand, Virusinfektionen oder Vitamin-D-Mangel) zum Ausbruch der Krankheit. Auch Krankheitsschübe können durch Umwelteinflüsse ausgelöst werden. Viele Krankheitsmanifestationen werden durch pathogene Autoantikörper (mit) bedingt, weshalb B‑Zellen und Plasmazellen von zentraler Bedeutung sind. Dieser Review gibt eine Übersicht über die häufigsten SLE-auslösenden Ursachen und wichtige Mechanismen der Pathogenese.
      PubDate: 2018-10-05
      DOI: 10.1007/s00393-018-0541-3
  • Update DVO-Leitlinie 2017 „Prophylaxe, Diagnostik und Therapie der
           Osteoporose bei postmenopausalen Frauen und Männern“
    • Authors: A. Pfeil; G. Lehmann; U. Lange
      PubDate: 2018-10-02
      DOI: 10.1007/s00393-018-0549-8
  • Differenzialdiagnostik von Lipödem und Lymphödem
    • Authors: U. Wollina; B. Heinig
      Abstract: Zusammenfassung Das Lipödem ist eine Erkrankung des subkutanen Fettgewebes der Extremitäten, die nahezu ausschließlich Frauen im postpubertären Alter betrifft. Charakteristisch ist die Kombination aus disfigurierender Fettgewebshypertrophie der proximalen Extremitäten, zunehmender Schmerzhaftigkeit und Hämatomneigung. Lymphödeme können primär oder sekundär bei beiden Geschlechtern auftreten. Typisch ist das Missverhältnis von Lymphlast und Kapazität der lymphatischen Gefäße. Stets sind die distalen Abschnitte des Körpers stärker betroffen als die proximalen. Zu Beginn ist das Lymphödem schmerzlos, im fortgeschrittenen Stadium kann ein Spannungsschmerz hinzutreten. Die Kombination beider Erkrankungen ist beschrieben, jedoch ist das Lipödem nicht als Ursache eines Lymphödems anzusehen, ganz im Gegenteil zur zentralen Adipositas. Diese erhöht das Risiko für Lymphödeme beträchtlich. Die Differenzierung der Diagnosen ist für eine sinnvolle Therapieplanung essenziell.
      PubDate: 2018-10-02
      DOI: 10.1007/s00393-018-0546-y
  • Rituximab in routine care of severe active rheumatoid arthritis
    • Authors: A. Krause; P. M. Aries; S. Berger; C. Fiehn; H. Kellner; H.-M. Lorenz; L. Meier; G. A. Müller; U. Müller-Ladner; A. Schwarting; H.-P. Tony; M. A. Peters; J. Wendler
      Abstract: Objective To assess safety, effectiveness and onset of effect of rituximab (RTX) in routine clinical treatment of severe, active rheumatoid arthritis (RA). Methods Prospective, multi-centre, non-interventional study in rheumatological outpatient clinics or private practices in Germany. RTX-naïve adult patients were to receive RTX according to marketing authorisation and at their physician’s discretion. Also according to their physician’s discretion, patients could receive a second cycle of RTX (re-treatment = treatment continuation). Major outcome was the change in Disease Activity Score based on 28-joints count and erythrocyte sedimentation rate (DAS28-ESR) over 24 weeks and during 6 months of re-treatment. Results Overall, 1653 patients received at least one cycle RTX; 99.2% of these had received disease-modifying antirheumatic drugs (DMARD) pre-treatment and 75.5% anti-tumor necrosis factor(TNF)‑α pre-treatment. After a mean interval of 8.0 months, 820 patients received RTX re-treatment. Mean DAS28-ESR decreased from 5.3 at baseline to 3.8 after 24 weeks (−1.5 [95% confidence interval, CI: −1.6; −1.4]), and from 4.1 at start of cycle 2 to 3.5 at study end (change from baseline: −1.8 [95% CI: −2.0; −1.7]). Improvements in DAS28-ESR and Health Assessment Questionnaire (HAQ) score occurred mainly during the first 12 weeks of RTX treatment, with further DAS28-ESR improvement until week 24 or month 6 of re-treatment. Improvements in DAS28-ESR and EULAR responses were more pronounced in seropositive patients. RF was a predictor of DAS28-ESR change to study end. Safety analysis showed the established profile of RTX. Conclusion RTX was safe and effective in a real-life setting with rapid and sustained improvement in RA signs and symptoms.
      PubDate: 2018-10-01
      DOI: 10.1007/s00393-018-0552-0
  • Refractory chylous pleural effusion with systemic lupus erythematosus
    • Authors: Peng Song; JingCheng Zhang; CongCong Shang; Li Zhang
      Abstract: We analyzed four cases of systemic lupus erythematosus (SLE) with chylous pleural effusion treated in our hospital from June 2013 to May 2017. The three females and one male ranged in age from 22 to 33 years. The length of disease course was 20 to 120 months. Treatment with glucocorticoids and immunosuppressants (cyclophosphamide or cyclosporine A) did not reduce chylous pleural effusion. Lymphatic obstruction was found in all patients after direct lymphangiography and the pleural effusion was significantly reduced after surgery. A literature search identified six previously reported patients with SLE and chylous pleural effusion. Five were sensitive to classic immunosuppression treatment, probably due to early intervention. However, as shown here, the thoracic duct can be involved in SLE, leading to an intractable chylous pleural effusion with no response to medical treatment. Surgery would be a better choice when lymphatic mechanical obstruction is found.
      PubDate: 2018-10-01
      DOI: 10.1007/s00393-018-0545-z
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Heriot-Watt University
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