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Publisher: Springer-Verlag (Total: 2354 journals)

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Showing 1001 - 1200 of 2354 Journals sorted alphabetically
Inorganic Materials: Applied Research     Hybrid Journal   (Followers: 1, SJR: 0.184, h-index: 6)
Insectes Sociaux     Hybrid Journal   (Followers: 3, SJR: 0.788, h-index: 45)
Instructional Science     Hybrid Journal   (Followers: 11, SJR: 1.418, h-index: 51)
Instruments and Experimental Techniques     Hybrid Journal   (Followers: 1, SJR: 0.29, h-index: 20)
Integral Equations and Operator Theory     Hybrid Journal   (Followers: 1, SJR: 1.348, h-index: 33)
Integrated Pest Management Reviews     Hybrid Journal   (Followers: 1)
Integrative Psychological and Behavioral Science     Hybrid Journal   (Followers: 5, SJR: 0.359, h-index: 18)
Intelligent Service Robotics     Hybrid Journal   (Followers: 3, SJR: 1.102, h-index: 16)
Intensive Care Medicine     Hybrid Journal   (Followers: 61, SJR: 3.765, h-index: 151)
Interactive Surgery     Hybrid Journal  
Interchange     Hybrid Journal   (Followers: 1, SJR: 0.131, h-index: 13)
Interdisciplinary Sciences : Computational Life Sciences     Hybrid Journal   (Followers: 2, SJR: 0.294, h-index: 10)
Intereconomics     Hybrid Journal   (Followers: 1, SJR: 0.195, h-index: 12)
Interest Groups & Advocacy     Hybrid Journal   (Followers: 2)
Internal and Emergency Medicine     Hybrid Journal   (Followers: 1, SJR: 0.757, h-index: 27)
Intl. Advances in Economic Research     Hybrid Journal   (Followers: 7, SJR: 0.155, h-index: 16)
Intl. Applied Mechanics     Hybrid Journal   (Followers: 3, SJR: 0.248, h-index: 31)
Intl. Archives of Occupational and Environmental Health     Hybrid Journal   (Followers: 7, SJR: 0.973, h-index: 69)
Intl. Cancer Conference J.     Hybrid Journal  
Intl. Commerce Review     Hybrid Journal   (Followers: 1)
Intl. Communication of Chinese Culture     Hybrid Journal   (Followers: 6)
Intl. Economics and Economic Policy     Hybrid Journal   (Followers: 4, SJR: 0.181, h-index: 14)
Intl. Entrepreneurship and Management J.     Hybrid Journal   (Followers: 8, SJR: 0.489, h-index: 27)
Intl. Environmental Agreements: Politics, Law and Economics     Hybrid Journal   (Followers: 13, SJR: 0.706, h-index: 24)
Intl. J. for Educational and Vocational Guidance     Hybrid Journal   (Followers: 6, SJR: 0.351, h-index: 16)
Intl. J. for Ion Mobility Spectrometry     Hybrid Journal   (Followers: 1, SJR: 0.832, h-index: 13)
Intl. J. for Philosophy of Religion     Hybrid Journal   (Followers: 51, SJR: 0.275, h-index: 10)
Intl. J. for the Advancement of Counselling     Hybrid Journal   (Followers: 3, SJR: 0.266, h-index: 18)
Intl. J. for the Semiotics of Law     Hybrid Journal   (Followers: 5, SJR: 0.143, h-index: 8)
Intl. J. of Advances in Engineering Sciences and Applied Mathematics     Hybrid Journal   (Followers: 1)
Intl. J. of Anthropology     Hybrid Journal   (Followers: 17)
Intl. J. of Applied and Computational Mathematics     Hybrid Journal  
Intl. J. of Artificial Intelligence in Education     Hybrid Journal   (Followers: 3, SJR: 0.567, h-index: 13)
Intl. J. of Asian Management     Hybrid Journal   (Followers: 3)
Intl. J. of Automation and Computing     Hybrid Journal   (SJR: 0.392, h-index: 23)
Intl. J. of Automotive Technology     Hybrid Journal   (Followers: 6, SJR: 0.847, h-index: 25)
Intl. J. of Behavioral Medicine     Hybrid Journal   (Followers: 5, SJR: 0.905, h-index: 46)
Intl. J. of Biometeorology     Hybrid Journal   (Followers: 1, SJR: 0.708, h-index: 63)
Intl. J. of Cardiovascular Imaging     Hybrid Journal   (SJR: 0.858, h-index: 45)
Intl. J. of Clinical Oncology     Hybrid Journal   (Followers: 10, SJR: 0.784, h-index: 45)
Intl. J. of Clinical Pharmacy     Partially Free   (Followers: 5, SJR: 0.575, h-index: 43)
Intl. J. of Colorectal Disease     Hybrid Journal   (Followers: 10, SJR: 1.102, h-index: 69)
Intl. J. of Computer Assisted Radiology and Surgery     Hybrid Journal   (Followers: 5, SJR: 0.539, h-index: 26)
Intl. J. of Computer Vision     Hybrid Journal   (Followers: 14, SJR: 5.633, h-index: 150)
Intl. J. of Computer-Supported Collaborative Learning     Hybrid Journal   (Followers: 16, SJR: 1.641, h-index: 39)
Intl. J. of Control, Automation and Systems     Hybrid Journal   (Followers: 12, SJR: 0.644, h-index: 33)
Intl. J. of Diabetes in Developing Countries     Open Access   (Followers: 8, SJR: 0.16, h-index: 16)
Intl. J. of Disclosure and Governance     Hybrid Journal   (Followers: 7, SJR: 0.156, h-index: 11)
Intl. J. of Dynamics and Control     Hybrid Journal   (Followers: 7)
Intl. J. of Early Childhood     Hybrid Journal   (Followers: 10, SJR: 0.407, h-index: 12)
Intl. J. of Earth Sciences     Hybrid Journal   (Followers: 39, SJR: 0.992, h-index: 70)
Intl. J. of Environmental Science and Technology     Hybrid Journal   (Followers: 5, SJR: 0.576, h-index: 46)
Intl. J. of Euro-Mediterranean Studies     Hybrid Journal   (Followers: 2, SJR: 0.132, h-index: 3)
Intl. J. of Fracture     Hybrid Journal   (Followers: 12, SJR: 1.093, h-index: 68)
Intl. J. of Fuzzy Systems     Hybrid Journal  
Intl. J. of Game Theory     Hybrid Journal   (Followers: 5, SJR: 0.878, h-index: 32)
Intl. J. of Geosynthetics and Ground Engineering     Full-text available via subscription   (Followers: 4)
Intl. J. of Group Tensions     Hybrid Journal   (Followers: 1)
Intl. J. of Health Care Finance and Economics     Hybrid Journal   (Followers: 8, SJR: 0.446, h-index: 21)
Intl. J. of Hematology     Hybrid Journal   (Followers: 5, SJR: 0.779, h-index: 60)
Intl. J. of Hindu Studies     Hybrid Journal   (Followers: 10, SJR: 0.166, h-index: 5)
Intl. J. of Historical Archaeology     Hybrid Journal   (Followers: 47, SJR: 0.522, h-index: 19)
Intl. J. of Information Security     Hybrid Journal   (Followers: 32, SJR: 0.652, h-index: 27)
Intl. J. of Information Technology     Hybrid Journal  
Intl. J. of Intelligent Transportation Systems Research     Hybrid Journal   (Followers: 9, SJR: 0.422, h-index: 6)
Intl. J. of Legal Medicine     Hybrid Journal   (Followers: 6, SJR: 1.372, h-index: 64)
Intl. J. of Machine Learning and Cybernetics     Hybrid Journal   (Followers: 10, SJR: 0.774, h-index: 20)
Intl. J. of Material Forming     Hybrid Journal   (Followers: 1, SJR: 0.504, h-index: 17)
Intl. J. of Mechanical and Materials Engineering     Open Access   (Followers: 7, SJR: 0.211, h-index: 13)
Intl. J. of Mechanics and Materials in Design     Hybrid Journal   (Followers: 6, SJR: 0.835, h-index: 15)
Intl. J. of Mental Health and Addiction     Hybrid Journal   (Followers: 19, SJR: 0.473, h-index: 22)
Intl. J. of Minerals, Metallurgy, and Materials     Hybrid Journal   (Followers: 10, SJR: 0.503, h-index: 21)
Intl. J. of Multimedia Information Retrieval     Partially Free   (Followers: 14)
Intl. J. of Occupational Medicine and Environmental Health     Hybrid Journal   (Followers: 19, SJR: 0.306, h-index: 33)
Intl. J. of Parallel Programming     Hybrid Journal   (Followers: 6, SJR: 0.255, h-index: 26)
Intl. J. of Peptide Research and Therapeutics     Partially Free   (Followers: 10, SJR: 0.329, h-index: 26)
Intl. J. of Plastics Technology     Hybrid Journal   (Followers: 2, SJR: 0.156, h-index: 4)
Intl. J. of Politics, Culture, and Society     Hybrid Journal   (Followers: 15, SJR: 0.198, h-index: 17)
Intl. J. of Precision Engineering and Manufacturing     Hybrid Journal   (Followers: 9, SJR: 0.659, h-index: 25)
Intl. J. of Precision Engineering and Manufacturing-Green Technology     Hybrid Journal   (Followers: 2, SJR: 1.316, h-index: 7)
Intl. J. of Primatology     Hybrid Journal   (Followers: 6, SJR: 1.078, h-index: 59)
Intl. J. of Public Health     Hybrid Journal   (Followers: 19, SJR: 1.21, h-index: 41)
Intl. J. of Rehabilitation and Health     Hybrid Journal   (Followers: 17)
Intl. J. of Salt Lake Research     Hybrid Journal   (Followers: 2)
Intl. J. of Science and Mathematics Education     Hybrid Journal   (Followers: 24, SJR: 0.851, h-index: 20)
Intl. J. of Self-Propagating High-Temperature Synthesis     Hybrid Journal   (Followers: 2, SJR: 0.304, h-index: 5)
Intl. J. of Sexuality and Gender Studies     Hybrid Journal   (Followers: 24)
Intl. J. of Social Robotics     Hybrid Journal   (Followers: 3, SJR: 1.198, h-index: 22)
Intl. J. of Speech Technology     Hybrid Journal   (Followers: 8, SJR: 0.295, h-index: 19)
Intl. J. of Steel Structures     Hybrid Journal   (Followers: 2, SJR: 0.557, h-index: 8)
Intl. J. of Stomatology & Occlusion Medicine     Hybrid Journal  
Intl. J. of Systems Assurance Engineering and Management     Hybrid Journal   (SJR: 0.291, h-index: 10)
Intl. J. of Technology and Design Education     Hybrid Journal   (Followers: 13, SJR: 0.573, h-index: 24)
Intl. J. of the Classical Tradition     Hybrid Journal   (Followers: 12, SJR: 0.111, h-index: 3)
Intl. J. of Theoretical Physics     Hybrid Journal   (Followers: 18, SJR: 0.399, h-index: 44)
Intl. J. of Thermophysics     Hybrid Journal   (Followers: 6, SJR: 0.431, h-index: 50)
Intl. J. of Wireless Information Networks     Hybrid Journal   (Followers: 5, SJR: 0.229, h-index: 22)
Intl. J. on Digital Libraries     Hybrid Journal   (Followers: 632, SJR: 0.375, h-index: 28)
Intl. J. on Document Analysis and Recognition (IJDAR)     Hybrid Journal   (Followers: 2, SJR: 0.546, h-index: 38)
Intl. J. on Interactive Design and Manufacturing (IJIDeM)     Hybrid Journal   (Followers: 3, SJR: 0.299, h-index: 12)
Intl. J. on Software Tools for Technology Transfer (STTT)     Hybrid Journal   (Followers: 5, SJR: 0.806, h-index: 41)
Intl. Ophthalmology     Hybrid Journal   (Followers: 5, SJR: 0.526, h-index: 33)
Intl. Orthopaedics     Hybrid Journal   (Followers: 15, SJR: 1.508, h-index: 59)
Intl. Politics     Hybrid Journal   (Followers: 31, SJR: 0.378, h-index: 22)
Intl. Politics Reviews     Hybrid Journal   (Followers: 4)
Intl. Review of Economics     Hybrid Journal   (Followers: 5, SJR: 0.165, h-index: 8)
Intl. Review of Education     Hybrid Journal   (Followers: 10, SJR: 0.369, h-index: 22)
Intl. Review on Public and Nonprofit Marketing     Hybrid Journal   (Followers: 2, SJR: 0.216, h-index: 6)
Intl. Sports Law J.     Hybrid Journal   (Followers: 3, SJR: 0.16, h-index: 1)
Intl. Tax and Public Finance     Hybrid Journal   (Followers: 8, SJR: 0.799, h-index: 37)
Intl. Urogynecology J.     Hybrid Journal   (Followers: 5, SJR: 0.955, h-index: 72)
Intl. Urology and Nephrology     Hybrid Journal   (Followers: 6, SJR: 0.506, h-index: 38)
Inventiones mathematicae     Hybrid Journal   (Followers: 1, SJR: 5.874, h-index: 75)
Invertebrate Neuroscience     Hybrid Journal   (Followers: 4, SJR: 0.566, h-index: 28)
Investigational New Drugs     Hybrid Journal   (Followers: 9, SJR: 1.376, h-index: 68)
Ionics     Hybrid Journal   (Followers: 2, SJR: 0.486, h-index: 36)
Iranian Polymer J.     Hybrid Journal   (Followers: 4, SJR: 0.517, h-index: 28)
Irish J. of Medical Science     Hybrid Journal   (Followers: 1, SJR: 0.298, h-index: 23)
Irrigation and Drainage Systems     Hybrid Journal   (Followers: 3)
Irrigation Science     Hybrid Journal   (Followers: 4, SJR: 1.193, h-index: 46)
Israel J. of Mathematics     Hybrid Journal   (Followers: 1, SJR: 1.649, h-index: 40)
Italian Economic J.     Hybrid Journal   (Followers: 27)
Izvestiya Atmospheric and Oceanic Physics     Hybrid Journal   (Followers: 3, SJR: 0.279, h-index: 17)
Izvestiya, Physics of the Solid Earth     Hybrid Journal   (Followers: 3, SJR: 0.394, h-index: 13)
J. Africain d'Hépato-Gastroentérologie     Hybrid Journal   (Followers: 2, SJR: 0.142, h-index: 3)
J. africain du cancer / African J. of Cancer     Hybrid Journal   (Followers: 2, SJR: 0.188, h-index: 4)
J. d'Analyse Mathématique     Hybrid Journal   (Followers: 3, SJR: 1.973, h-index: 36)
J. for General Philosophy of Science     Hybrid Journal   (Followers: 6, SJR: 0.207, h-index: 10)
J. for Labour Market Research     Open Access   (Followers: 8)
J. fur Asthetische Chirurgie     Hybrid Journal   (SJR: 0.117, h-index: 4)
J. für Betriebswirtschaft     Hybrid Journal   (Followers: 1, SJR: 0.195, h-index: 9)
J. für Mathematik-Didaktik     Hybrid Journal   (SJR: 0.226, h-index: 7)
J. für Rechtspolitik     Hybrid Journal  
J. für Verbraucherschutz und Lebensmittelsicherheit     Hybrid Journal   (SJR: 0.221, h-index: 17)
J. of Abnormal Child Psychology     Hybrid Journal   (Followers: 6, SJR: 2.03, h-index: 107)
J. of Academic Ethics     Hybrid Journal   (Followers: 4, SJR: 0.395, h-index: 10)
J. of Acupuncture and Tuina Science     Hybrid Journal   (Followers: 3, SJR: 0.216, h-index: 6)
J. of Adult Development     Hybrid Journal   (Followers: 8, SJR: 0.463, h-index: 30)
J. of Advancement in Medicine     Hybrid Journal  
J. of African American Studies     Hybrid Journal   (Followers: 8, SJR: 0.155, h-index: 8)
J. of Aging and Identity     Hybrid Journal   (Followers: 8)
J. of Agricultural and Environmental Ethics     Hybrid Journal   (Followers: 8, SJR: 0.508, h-index: 32)
J. of Agricultural, Biological & Environmental Statistics     Hybrid Journal   (Followers: 10, SJR: 0.571, h-index: 39)
J. of Algebraic Combinatorics     Hybrid Journal   (Followers: 3, SJR: 1.436, h-index: 27)
J. of Ambient Intelligence and Humanized Computing     Hybrid Journal   (Followers: 1, SJR: 0.456, h-index: 11)
J. of Analytical Chemistry     Hybrid Journal   (Followers: 23, SJR: 0.268, h-index: 23)
J. of Analytical Science & Technology     Open Access   (Followers: 6)
J. of Anesthesia     Hybrid Journal   (Followers: 12, SJR: 0.513, h-index: 30)
J. of Applied and Industrial Mathematics     Hybrid Journal   (SJR: 0.176, h-index: 8)
J. of Applied Electrochemistry     Hybrid Journal   (Followers: 14, SJR: 0.676, h-index: 86)
J. of Applied Genetics     Partially Free   (Followers: 1, SJR: 0.621, h-index: 38)
J. of Applied Mathematics and Computing     Hybrid Journal   (SJR: 0.483, h-index: 24)
J. of Applied Mechanics and Technical Physics     Hybrid Journal   (Followers: 7, SJR: 0.199, h-index: 13)
J. of Applied Phycology     Hybrid Journal   (Followers: 10, SJR: 0.852, h-index: 73)
J. of Applied Spectroscopy     Hybrid Journal   (Followers: 8, SJR: 0.18, h-index: 15)
J. of Archaeological Method and Theory     Hybrid Journal   (Followers: 64, SJR: 1.464, h-index: 34)
J. of Archaeological Research     Hybrid Journal   (Followers: 54, SJR: 1.681, h-index: 36)
J. of Arid Land     Hybrid Journal   (Followers: 1, SJR: 0.56, h-index: 9)
J. of Artificial Organs     Hybrid Journal   (SJR: 0.66, h-index: 29)
J. of Asset Management     Partially Free   (Followers: 2, SJR: 0.181, h-index: 6)
J. of Assisted Reproduction and Genetics     Hybrid Journal   (Followers: 4, SJR: 0.858, h-index: 57)
J. of Astrophysics and Astronomy     Open Access   (Followers: 41, SJR: 0.226, h-index: 19)
J. of Atmospheric Chemistry     Hybrid Journal   (Followers: 22, SJR: 0.599, h-index: 59)
J. of Autism and Developmental Disorders     Hybrid Journal   (Followers: 41, SJR: 1.877, h-index: 123)
J. of Automated Reasoning     Hybrid Journal   (SJR: 1.63, h-index: 43)
J. of Banking Regulation     Hybrid Journal   (Followers: 24, SJR: 0.16, h-index: 7)
J. of Behavioral Education     Hybrid Journal   (Followers: 4, SJR: 0.763, h-index: 28)
J. of Behavioral Health Services & Research     Hybrid Journal   (Followers: 13, SJR: 0.555, h-index: 41)
J. of Behavioral Medicine     Hybrid Journal   (Followers: 3, SJR: 1.069, h-index: 73)
J. of Bio- and Tribo-Corrosion J. of Bio- and Tribo-Corrosion     Hybrid Journal   (Followers: 1)
J. of Bioeconomics     Hybrid Journal   (SJR: 0.391, h-index: 18)
J. of Bioenergetics and Biomembranes     Hybrid Journal   (Followers: 1, SJR: 1.092, h-index: 83)
J. of Bioethical Inquiry     Hybrid Journal   (Followers: 3, SJR: 0.396, h-index: 13)
J. of Biological Physics     Hybrid Journal   (SJR: 0.481, h-index: 33)
J. of Biomedical Science     Open Access   (Followers: 4, SJR: 1.28, h-index: 59)
J. of Biomolecular NMR     Hybrid Journal   (Followers: 7, SJR: 2.043, h-index: 89)
J. of Biorheology     Hybrid Journal   (SJR: 0.122, h-index: 7)
J. of Biosciences     Open Access   (SJR: 0.841, h-index: 54)
J. of Bone and Mineral Metabolism     Hybrid Journal   (Followers: 3, SJR: 0.775, h-index: 56)
J. of Brand Management     Hybrid Journal   (Followers: 17, SJR: 0.535, h-index: 22)
J. of Business and Psychology     Hybrid Journal   (Followers: 7, SJR: 1.385, h-index: 46)
J. of Business Economics     Hybrid Journal   (Followers: 6)
J. of Business Ethics     Hybrid Journal   (Followers: 35, SJR: 1.358, h-index: 98)
J. of Cancer Education     Hybrid Journal   (Followers: 3, SJR: 0.525, h-index: 33)
J. of Cancer Research and Clinical Oncology     Hybrid Journal   (Followers: 15, SJR: 1.19, h-index: 76)
J. of Cancer Survivorship     Hybrid Journal   (Followers: 5, SJR: 2, h-index: 34)
J. of Cardiovascular Translational Research     Hybrid Journal   (Followers: 1, SJR: 1.567, h-index: 32)
J. of Cell Communication and Signaling     Hybrid Journal   (SJR: 1.195, h-index: 27)
J. of Central South University     Hybrid Journal   (Followers: 1, SJR: 0.335, h-index: 20)
J. of Chemical Biology     Hybrid Journal   (Followers: 3, SJR: 0.685, h-index: 14)
J. of Chemical Crystallography     Hybrid Journal   (Followers: 2, SJR: 0.25, h-index: 28)
J. of Chemical Ecology     Hybrid Journal   (Followers: 7, SJR: 1.559, h-index: 88)
J. of Chemical Sciences     Partially Free   (Followers: 22, SJR: 0.322, h-index: 37)
J. of Child and Adolescent Group Therapy     Hybrid Journal   (Followers: 2)
J. of Child and Family Studies     Hybrid Journal   (Followers: 21, SJR: 0.549, h-index: 50)
J. of Children's Orthopaedics     Hybrid Journal   (Followers: 9, SJR: 0.584, h-index: 18)
J. of Chinese Political Science     Hybrid Journal   (Followers: 7, SJR: 0.515, h-index: 9)
J. of Chinese Sociology     Open Access   (Followers: 2)
J. of Civil Structural Health Monitoring     Hybrid Journal   (Followers: 4, SJR: 0.296, h-index: 7)
J. of Classification     Hybrid Journal   (Followers: 7, SJR: 0.968, h-index: 29)

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Journal Cover Neurophysiology
  [SJR: 0.168]   [H-I: 9]   [1 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1573-9007 - ISSN (Online) 0090-2977
   Published by Springer-Verlag Homepage  [2354 journals]
  • Ethical Responsibilities of the Authors
    • Pages: 245 - 245
      PubDate: 2017-08-01
      DOI: 10.1007/s11062-017-9677-z
      Issue No: Vol. 49, No. 4 (2017)
       
  • Expression of Vascular Endothelial Growth Factor after Transfection of
           Human Neural Stem Cells with the Lentiviral Vector Encoding the VEGF165
           Gene
    • Authors: Zh. Su; H. Jing; Zh. Zhang; M. Tu; H. Ying; Q. Zhuge; Ya. Zeng; Yu Zhang
      Pages: 246 - 253
      Abstract: We examined the expression of vascular endothelial growth factor (VEGF) and characteristics of human neural stem cells after transfection with the lentiviral vector encoding the VEGF 165 gene. The latter gene was amplified from the human breast cancer cell line MCF-7 using RT-PCR; then the target gene was cloned into the pCDH–CMV–MCS-EF1-copGFP, a lentiviral expressing plasmid. After transformation, enzyme digestion led to a correct length of the VEGF165 gene, and DNA sequencing analysis confirmed that the VEGF165 gene sequence was exactly the same as that reported by the GeneBank. Then, the recombinant lentivirus produced by 293T cells and packaging plasmids were transfected into fourthpassage human neural stem cells (NSCs). One week after transfection with pCDH-VEGF165, NSCs expressed VEGF stably, and their proliferation ability significantly increased. Furthermore, human NSCs kept their characteristics and multiple differentiation activity after transfection. Our results indicate that human NSCs can express vascular endothelial growth factor highly and stably via transfection with the lentiviral vector encoding the VEGF165 gene, which may be useful for future research on function recovery after stroke.
      PubDate: 2017-08-01
      DOI: 10.1007/s11062-017-9678-y
      Issue No: Vol. 49, No. 4 (2017)
       
  • Expression of Calcium-Binding Proteins, Calbindin D28k and Calretinin, in
           the Frog Taste Receptor Structures
    • Authors: H. Ando; Y. Imamura; O. Tadokoro; M. Z. Hossin; S. Unno; N. Sogawa; E. Kondo; J. Kitagawa
      Pages: 254 - 260
      Abstract: Considering that information on the expression of calcium-binding proteins (CaBPs) in different cells of the taste receptors is rather limited, we investigated the distribution of such proteins, calbindin D28k (CB) and calretinin (CR), in the taste disc (TD) of the frog Lithobates catesbeianus. Western blot analysis revealed that CB and CR are expressed in cells of the fungiform papillae. CB-immunoreactive (ir) and CR-ir cell somata were located in the middle layer of the TD. Most CB-ir and CR-ir cells possessed one rod-shaped apical process and one basal process; in some cells there were several extended basal processes. Apical processes of CR-ir cells were thinner than those of CB-ir units, and CR-ir nerve fibers were ramified in the lamina propria directly below the TD. Most CR-ir fiber branches surrounded the TD; however, some penetrated this region, with both types of branches approaching the surface. CB and CR immunoreactivities did not co-occur in TD cells. In the TDs examined, the number of CB-ir cells was significantly greater than that of CR-ir units. Our observations suggest that CB-ir and CR-ir cells in the frog TD correspond to type-II and type-III cells, respectively.
      PubDate: 2017-08-01
      DOI: 10.1007/s11062-017-9679-x
      Issue No: Vol. 49, No. 4 (2017)
       
  • Effects of a Propolis Extract on the Viability of and Levels of
           Cytoskeletal and Regulatory Proteins in Rat Brain Astrocytes: an In Vitro
           Study
    • Authors: C. A. Agca; A. A. Tykhomyrov; G. Baydas; V. S. Nedzvetsky
      Pages: 261 - 271
      Abstract: A potential for the use of propolis in preventive and therapeutic purposes has been acknowledged, but little attention has been paid to estimation of possible propolis cytotoxicity with respect to astrocytes. We tried to estimate how a propolis ethanol extract (PEE) affects rat brain astrocytes in vitro and also to uncover crucial molecular targets of the PEE action. Primary astrocytes were exposed to PEE in doses of 10, 25, or 100 μg/ml for 24 h, and then the cell viability was monitored by MTT assay. Levels of glial fibrillary acidic protein (GFAP), transcriptional nuclear factor-κB (NF-κB), poly(ADPribose) polymerase (PARP), and angiostatins were measured using Western blot to identify the molecular mechanisms underlying cell responses to PEE. The PEE treatment exerted a dose-dependent cytotoxic effect on cultured astrocytes. The PEE modulated astrocyte signaling pathways through inducing the expression of NF-κB and PARP. At the same time, the PEE stimulated GFAP synthesis and fibrillogenesis, which was indicative for activation of astrocytes preceding their suppression. The PEE significantly increased the production of angiostatin isoforms by astrocytes, thus contributing to an antiangiogenic potential of these cells. In summary, our results indicated that exposure to the PEE exerts certain cytotoxic effects on astrocytes in a dose-dependent manner; these effects are realized through modulation of cytoskeleton rearrangements and pro-apoptotic signaling pathways. A widely available, safe, and inexpensive substance, propolis, and its components and derivatives may be used in the prevention and treatment of neuronal impairments, including malignant tumors and neurodegenerative disorders associated with excessive astrocytic activation.
      PubDate: 2017-08-01
      DOI: 10.1007/s11062-017-9680-4
      Issue No: Vol. 49, No. 4 (2017)
       
  • Effects of Transcranial Direct Current Stimulation of Rat Cerebral
           Structures on Pentylenetetrazole-Induced Seizures
    • Authors: L. S. Godlevsky; O. M. Nenova; M. P. Pervak; T. V. Prybolovets; K. A. Bidnyuk
      Pages: 272 - 275
      Abstract: In rats with a kindling syndrome induced by injections of pentylenetetrazole (PTZ, 30.0 mg/kg, i.p., for three weeks), the latent periods of seizures induced by test doses of PTZ (30 mg/kg) were, on average, 37.5% greater than those in the control (P < 0.05) after transcranial direct current stimulation (TDCS, 600 μA, 15.0 min, cathode on the skull surface) oriented to the cerebellar cortex. Such stimulation prevented initiation of generalized clonico-tonic seizures; the duration of ictal discharges in brain structures decreased, on average, by 42.1% (P < 0.02). The latent periods of acute PTZ-induced (60.0 mg/kg) seizures in rats that were not subjected to the kindling procedure were 33.5% longer after TDCS (P < 0.05) than those in the control. Similar stimulation focused on the frontal cerebral cortex prevented the development of generalized seizures in 50% of the kindling rats (P < 0.05).
      PubDate: 2017-08-01
      DOI: 10.1007/s11062-017-9681-3
      Issue No: Vol. 49, No. 4 (2017)
       
  • Postvaccination Accumulation of the Influenza Virus Antigen in the Rat
           Choroid Plexus
    • Authors: I. Maslovarič; A. Stojkovič; D. Kosanovič; D. Markovič; V. Ilič; K. Jovanova-Nelič
      Pages: 276 - 282
      Abstract: We examined the accessibility of influenza virus and diphtheria-tetanus toxin (DiTe) antigens to the choroid plexus (CP) within the postvaccination period and the expression of CD11b molecules (by immunohistochemistry). Eighteen Dark Agouti (DA) rats were divided into three groups: (i) animals administered with influenza vaccine (Flu), (ii) animals administered with DiTe vaccine (DiTe), and (iii) nontreated (Contr) animals. The serum antibody titers following influenza and diphtheria-tetanus vaccination were detected by the ELISA test. Immunohistochemical staining revealed a great number of viral antigen-positive and CD11b-positive brain cells in Flu rats compared to a very small number of the respective cells in DiTe animals and no staining in the Contr group. DiTe- and Flu-rats showed significant increases in the serum anti-tetanus toxoid and anti-influenza virus antibody levels compared to those in the Contr group. The results obtained attract attention towards the dynamic role of the CP in the immunosurveillance of the CNS. Based on the viral antigen deposits accumulated in the CP, it has been proposed that the latter can play an active role in modulation of the immune response after influenza vaccine immunization.
      PubDate: 2017-08-01
      DOI: 10.1007/s11062-017-9682-2
      Issue No: Vol. 49, No. 4 (2017)
       
  • Effects of Beta-Adrenergic Blockade on Diabetes-Induced Neurobehavioral
           Alterations in Mice
    • Authors: G. F. Ibironnke; O. S. Asifat
      Pages: 283 - 287
      Abstract: Neurobehavioral activities were estimated in three groups of male albino mice using the open field, elevated plus maze, light/dark board, and hole-board tests. The control group included intact animals, while alloxan-induced diabetes was evoked in the other two groups (single i.p. injection of 120 mg/kg alloxan). In the third group, a nonspecific beta-adrenoreceptor antagonist, propranolol, was i.p. injected (40 mg/kg) before the induction of diabetes. In diabetic mice, all neurobehavioral indices tested in the four above-mentioned tests were significantly (P< 0.05) smaller than those in the control group. The frequencies of rearings and grooming episodes in the open field, number of entries into the open arms and time spent in these arms in the elevated plus maze test, and number of head dips in the hole-board test demonstrated the most intense drops (more than twofold). Pretreatment with propranolol provided significant (P < 0.05) normalization of all neurobehavioral indices in diabetic mice; such normalization with respect to the locomotion intensity, frequency of grooming, time spent in the open arms, and both indices in the light/dark board was nearly complete. Thus, diabetes in the animal model used is accompanied by the development of the state of abnormally high anxiety. The activity of the betaadrenergic system is noticeably involved in the formation of this state; pharmacological blocking of beta-adrenoreceptors provides significant anxiolytic effects.
      PubDate: 2017-08-01
      DOI: 10.1007/s11062-017-9683-1
      Issue No: Vol. 49, No. 4 (2017)
       
  • Muscle Ergoreflex Activity and Autonomic Balance Assessed in the Vertical
           and Horizontal Body Positions in Young Healthy Men
    • Authors: A. Siennicka; M. Tkaczyszyn; K. Ludwikowska; W. Banasiak; M. Piepoli; P. Ponikowski; E. A. Jankowska
      Pages: 288 - 294
      Abstract: We investigated whether indices of the reflex regulation of the cardiovascular system, i.e., muscle ergoreflex activity (ERGO) and characteristics of the autonomic balance, differ from each other while measured in the vertical vs. horizontal positions in healthy humans. Ten young healthy men (mean age 28 ± 1 years; BMI 23.6 ± 0.8 kg/m2) were examined. In each subject, the ERGO (ventilatory response to a control handgrip exercise, with repetitive isometric contractions at 50% of the maximal strength), baroreflex sensitivity (BRS, the sequence method), heart rate variability (HRV), and a few hemodynamic parameters were measured in two positions, horizontal and vertical. In the latter position, the heart rate, and diastolic and mean blood pressures (BP) were higher, while the stroke volume was smaller (all P < 0.05) with no differences in the systolic BP, cardiac output, and systemic vascular resistance (all P > 0.2). The HRV time domains, as well as BRS, decreased, whereas HRV-LF increased (all P < 0.05) in the vertical position as compared to the horizontal one. There were no differences between other HRV parameters (all P > 0.2) in the two examined positions. Minute ventilation during the exercise increased, while ERGO was reduced in the vertical position (all P < 0.05). Thus, the body position noticeably affects both reflex regulation of the cardiovascular system and autonomic balance. This observation has to be taken into account during physiological testing.
      PubDate: 2017-08-01
      DOI: 10.1007/s11062-017-9684-0
      Issue No: Vol. 49, No. 4 (2017)
       
  • Control of the Functionality of the Brachial Plexus during Robot-Assisted
           Transaxillary Thyroid Surgery
    • Authors: D. D. Axente; Z. Z. Major; V. N. Dudric; N. A. Constantea
      Pages: 295 - 300
      Abstract: At present, such a type of endoscopic surgery as robot-assisted transaxillary thyroidectomy has become available. In this case, traumatization of the brachial plexus is a rare but possible complication. For the control of the function of the brachial plexus during the above operation we used monitoring of somatosensory evoked potentials (SSEPs) induced by stimulation of the median nerve. Fifteen patients (14 women and one man) were included in this study. All interventions were robot-assisted transaxillary thyroidectomies using the daVinci SI Surgical System. We found that such surgery induced mild but significant increases in the latency of the cortical N20 potential, especially when the tissue was tensioned by the autostatic retractor. The latency prolongation was a valuable signal given to the surgeon, followed by repositioning or loosening of the retractor. In the examined group, no significant decreases in the amplitude of the N20 potential were observed. We conclude that SSEP monitoring during robotic thyroid surgery is an available and safe method providing valuable information on the functional integrity of somatosensory pathways during surgical maneuvers.
      PubDate: 2017-08-01
      DOI: 10.1007/s11062-017-9685-z
      Issue No: Vol. 49, No. 4 (2017)
       
  • Spontaneous Synaptic Activity in Projection Neurons of Lamina I of the
           Isolated Rat Lumbar Spinal Cord: Effect of Peripheral Inflammation
    • Authors: D. P. Shevchuk; K. S. Agashkov; P. V. Bilan; N. V. Voitenko
      Pages: 301 - 304
      Abstract: Spino-cerebral (projection) neurons localized in lamina I of the spinal gray substance play an important role in the transmission of pain-related information to the brain. We examined spontaneous excitatory postsynaptic currents (sEPSC) recorded from lamina I spino-pontine neurons in isolated preparations of the rat lumbar spinal cord; the respective neurons were retrogradely labeled by a fluorescent dye. We tried to find out how experimentally induced peripheral inflammation affects the amplitude/time characteristics of these currents. It was found that, in preparations obtained from animals with inflammation of hind limb tissues, the frequency and (to a lesser extent) amplitude of sEPSC in projection neurons are, on average, higher than those measured in neurons of the control animals. It is belived that such changes result mostly from plastic modifications of neuron-to-neuron interactions in neuronal networks of lamina II, which form main synaptic inputs to neurons of lamina I. Increased frequency and amplitude of sEPSC in lamina I neurons should lead to some facilitation of transmission of nociceptive information to the cerebral structures. Such hyperexcitability of lamina 1 projection neurons can provide a notable contribution to the development of hyperalgesia in chronic inflammatory states and to facilitation of generation of pain-related emotions.
      PubDate: 2017-08-01
      DOI: 10.1007/s11062-017-9686-y
      Issue No: Vol. 49, No. 4 (2017)
       
  • Neuroprotective Effect of Curcumin on LPS-activated Astrocytes Is Related
           to the Prevention of GFAP and NF-κB Upregulation
    • Authors: V. S. Nedzvetsky; C. A. Agca; S. V. Kyrychenko
      Pages: 305 - 307
      Abstract: We examined the effects of 2.0 μM curcumin, a known antioxidant, on the cultures of normal rat astrocytes and of those subjected to the action of 0.01 μM lipopolysaccharide, LPS. As was found, 24-h-long exposure of astrocytes to LPS resulted in a relatively mild decrease in the cell viability of astrocytes (a decrement of 22%). The action of curcumin significantly ameliorated this decrease. LPS induced significant upregulation of GFAP, NF-κB, and poly(ADP-ribose)polymerase (PARP) in activated astrocytes. Curcumin significantly decreased these effects (to 60, 71, and 89% as compared to those in astrocytes subjected to isolated action of LPS). Thus, curcumin significantly prevents the decrease in cell viability and moderates the cytoskeleton rearrangements and disorders in NF-κBdependent regulation in astrocytes activated by LPS.
      PubDate: 2017-08-01
      DOI: 10.1007/s11062-017-9687-x
      Issue No: Vol. 49, No. 4 (2017)
       
  • Hysteresis in EMG Activity of Muscles of the Human Upper Limb at Rotations
           of the Isometric Effort Vector
    • Authors: M. Dornowski; O. V. Lehedza; V. S. Mishchenko; A. V. Gorkovenko
      Pages: 308 - 312
      Abstract: We studied the dynamics of EMG activity of muscles of the human upper limb under conditions of changes in the direction of a vector of the isometric effort created by the hand. Averaged EMG activities of seven muscles of the shoulder and shoulder girdle at nine combinations of the angles in the shoulder and elbow joints were evaluated. Mean values of the angles of the maximum activity (AMAs) of the muscle during slow counterclockwise and clockwise rotations of the above-mentioned vector were compared. A significant dependence of the AMA in a considerable part of the muscles on the direction of the target trajectory hodograph by the vector of the generated effort was observed; this dependence is, most likely, due to the manifestations of hysteresis in the activity of the examined muscles. In the case where the analysis was performed in more detail, AMA values for the mm. triceps brachii, pectoralis major, and deltoideus pars scapularis were significantly greater at clockwise rotation, while those for the m. brachioradialis demonstrated an opposite trend.
      PubDate: 2017-08-01
      DOI: 10.1007/s11062-017-9688-9
      Issue No: Vol. 49, No. 4 (2017)
       
  • Correction to: Somatosensory and Motor Functions in Smartphone Systematic
           Users and Non-Users
    • Authors: Y. M. Lim; Y. R. Kang; S. Y. Kang
      Pages: 313 - 313
      Abstract: In the article metadata on SpringerLink, the email icon should appear after S. Y. Kang.
      PubDate: 2017-08-01
      DOI: 10.1007/s11062-017-9689-8
      Issue No: Vol. 49, No. 4 (2017)
       
  • Ethical Responsibilities of The Authors
    • Pages: 177 - 177
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9670-6
      Issue No: Vol. 49, No. 3 (2017)
       
  • Effects of Gold and Silver Nanoparticles on Kisspeptin-Mediated Regulation
           of the Hypothalamo-Pituitary-Gonadal Axis
    • Authors: V. Ye. Kalynovskyi; A. S. Pustovalov; G. Ya. Grodzyuk; N. S. Andryushina; M. E. Dzerzhynskyi
      Pages: 194 - 199
      Abstract: The features of morphofunctional reactions (changes in the size of the nuclei of neurocytes) were examined in neurons of the arcuate and preoptic nuclei (AN and PON, respectively) of the rat hypothalamus. These reactions were caused by the introduction of nanoparticles (NPs) of gold and silver (AuNPs and AgNPs, respectively) under conditions of activation and blocking of kisspeptin-mediated signaling in one- and six-month-old rat males. The intraperitoneal (i.p.) administration of both AuNPs and AgNPs caused decreases in the size of the mentioned neuronal nuclei in animals of both age groups. These effects indicate that systemic introductions of NPs of both metals suppress the activity of the hypothalamo-pituitary-gonadal axis. Upon combined introduction of NPs with intracerebroventricular injections of an activator or a blocker of kisspeptinergic signaling, independent actions of the applied agents on the PON neurons were observed. Arcuate neurons of young rats in the case of combined injections retained the susceptibility to injections of kisspeptin but not to those of its antagonist; such neurons in adult rats responded in the opposite way. The obtained results demonstrated that both AuNPs and AgNPs exert nonspecific toxic effects on the functioning of the central regulator of the reproductive system in male rats.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9673-3
      Issue No: Vol. 49, No. 3 (2017)
       
  • Pain Sensitivity and Behavioral Indices in Mice Exposed to Glutamate
           Toxicity: Neuroprotective Effects of Vitamin Supplementation
    • Authors: T. S. Adu; D. C. Ajonijebu; O. S. Akinsomosoye
      Pages: 208 - 214
      Abstract: We examined the effects of glutamate toxicity induced by chronic (for 21 days) intraperitoneal (i.p.) introductions of monosodium glutamate (MSG, 4 mg/kg per day) into albino mice. It was found that such treatment significantly (P < 0.05) decreased the latencies of defensive motor responses in the hot plate and tail withdrawal tests, as compared with the respective indices in the control group (injected with saline). This treatment also led to dramatic decreases (P < 0.05) in the intensities of locomotor activity and orientational/research phenomena (rearings) in the open field test; the number of grooming episodes also considerably decreased. Glutamate intoxication also provided significant (P < 0.05) decreases in the time spent in the open arms of the elevated plus maze and in the number of entries in these arms. Introductions of 200 mg/kg vitamin C, as well as of 20 mg/kg vitamin E, into MSG-treated mice significantly (P < 0.05) increased the response latencies in the hot plate and tail withdrawal tests; the respective values became even greater than those in the norm. Injections of both vitamins also partly normalized the values reflecting the intensity of locomotion and rearings and nearly completely normalized grooming behavior. These vitamins provided also clear trends toward normalization with respect to the anxiety indices in the elevated plus maze test. Thus, glutamate intoxication leads to the development of a hyperalgesic state, significant suppression of behavioral activities, and a significant increase in the anxiety level. Introductions of vitamins C and E known as effective antioxidants considerably moderate these negative shifts.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9665-3
      Issue No: Vol. 49, No. 3 (2017)
       
  • Somatosensory and Motor Functions in Smartphone Systematic Users and
           Non-Users
    • Authors: Y. M. Lim; Y. R. Kang; S. Y. Kang
      Pages: 215 - 219
      Abstract: We investigated the effect of systematic smartphone usage on the motor and somatosensory finger functions in healthy subjects. Seventeen right-handed healthy volunteers participated in the study. A somewhat better finger sensorimotor function was observed in smartphone non-users. Within the group of smartphone systematic users, the amount of smartphone usage negatively correlated with the spatial discrimination threshold in the fingers. These findings suggest that the input method of the device may not be the only factor influencing the sensorimotor function (other structural differences of the input may also contribute), and that frequent use of the fingers might enhance spatial discrimination. The respective studies can help us to understand interaction between the sensorimotor function and tools and give some insight on how newly developed tools may affect the human brain.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9666-2
      Issue No: Vol. 49, No. 3 (2017)
       
  • Electrical Activity of the Cerebral Structures and Regulatory Effects of
           NO, Steroid Hormones, and BDNF in Rats with Experimental Alcohol Addiction
           
    • Authors: O. G. Berchenko; A. M. Titkova; O. V. Veselovs’ka; A. V. Shlyakhova; N. O. Levicheva; O. O. Prikhod’ko
      Pages: 234 - 236
      Abstract: In a chronic experiment on rats with induced alcohol addiction, it was shown that chronic alcoholization leads to decreases in the levels of cortisol and testosterone in the hypothalamus, amygdalar complex, and blood serum. Functional changes in the hippocampus and nucl. accumbens are believed to play a leading role in the formation of the alcohol withdrawal syndrome. Under these conditions, the level of NO metabolites in the above structures decreases against the background of increased BDNF concentrations in blood serum.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9668-0
      Issue No: Vol. 49, No. 3 (2017)
       
  • Effect of Sensitization by Cerebral Antigen on Expression of Synaptophysin
           in the Sensorimotor Cortex under Conditions of Ischemia and
           Immunocorrection of its Consequences
    • Authors: L. M. Yaremenko; O. M. Grabovyi; S. Ye. Shepelev
      Pages: 237 - 239
      Abstract: In rats sensitized with cerebral antigen, the level of synaptophysin (SYP) expression in the sensorimotor cortex was significantly lower than that in the intact control (on the 13th, 15th, 22nd, and 42nd but not on the 102nd day after sensitization). In preliminarily sensitized animals with experimentally induced acute impairment of cerebrovascular flow, this index in the affected hemisphere was significantly lower than that in the contralateral intact hemisphere (after 3, 10, and 30 days) and that in sensitized animals without such disorders (after 1, 3, 10 and 30 days). The treatment with an immunomodulator, Imunofan, provided a rapid short-lasting (one–two days) increase in the expression of SYP in both affected and contralateral hemispheres; a significant difference of this index in the two hemispheres, however, was preserved during at least 10 days.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9669-z
      Issue No: Vol. 49, No. 3 (2017)
       
  • Cortical Visual Evoked Potentials in Subjects with Auditory Deprivation
           (Congenital Deafness)
    • Authors: L. I. Yukhymenko
      Pages: 240 - 243
      Abstract: In 30 healthy men (age 19–25 years) with normal hearing and 30 men of the same age suffering from complete congenital deafness, we examined peculiarities of the cortical visual evoked potentials, VEPs (photostimulation of the right and left eye by LED flashes, recording from loci O1 and O2). It was found that subjects with auditory deprivation demonstrated significantly shorter (P < 0.05–0.001) peak latencies of the early VEP components (P1, N2, and P2), while peak latencies of the late waves (N2 and P3) were greater (P < 0.05) than the corresponding indices in the control group. Peak-to-peak amplitudes of all VEP components in deaf subjects were about two to three times lower than those in subjects with normal hearing (P < 0.05–0.001). The mean total duration of the VEPs in deaf persons was significantly greater than in the control group (P < 0.05). Therefore, loss of the auditory function in deaf subjects results, due to cross-modal transformations, in substantial modifications of the potentials reflecting perception of the visual signals.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9676-0
      Issue No: Vol. 49, No. 3 (2017)
       
 
 
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