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Publisher: Springer-Verlag   (Total: 2345 journals)

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Showing 1001 - 1200 of 2345 Journals sorted alphabetically
Integrated Pest Management Reviews     Hybrid Journal   (Followers: 1)
Integrative Psychological and Behavioral Science     Hybrid Journal   (Followers: 5, SJR: 0.359, h-index: 18)
Intelligent Service Robotics     Hybrid Journal   (Followers: 2, SJR: 1.102, h-index: 16)
Intensive Care Medicine     Hybrid Journal   (Followers: 52, SJR: 3.765, h-index: 151)
Interactive Surgery     Hybrid Journal  
Interchange     Hybrid Journal   (Followers: 1, SJR: 0.131, h-index: 13)
Interdisciplinary Sciences : Computational Life Sciences     Hybrid Journal   (Followers: 2, SJR: 0.294, h-index: 10)
Intereconomics     Hybrid Journal   (Followers: 1, SJR: 0.195, h-index: 12)
Interest Groups & Advocacy     Hybrid Journal   (Followers: 1)
Internal and Emergency Medicine     Hybrid Journal   (Followers: 1, SJR: 0.757, h-index: 27)
Intl. Advances in Economic Research     Hybrid Journal   (Followers: 6, SJR: 0.155, h-index: 16)
Intl. Applied Mechanics     Hybrid Journal   (Followers: 3, SJR: 0.248, h-index: 31)
Intl. Archives of Occupational and Environmental Health     Hybrid Journal   (Followers: 7, SJR: 0.973, h-index: 69)
Intl. Cancer Conference J.     Hybrid Journal  
Intl. Commerce Review     Hybrid Journal   (Followers: 1)
Intl. Communication of Chinese Culture     Hybrid Journal   (Followers: 5)
Intl. Economics and Economic Policy     Hybrid Journal   (Followers: 3, SJR: 0.181, h-index: 14)
Intl. Entrepreneurship and Management J.     Hybrid Journal   (Followers: 8, SJR: 0.489, h-index: 27)
Intl. Environmental Agreements: Politics, Law and Economics     Hybrid Journal   (Followers: 13, SJR: 0.706, h-index: 24)
Intl. J. for Educational and Vocational Guidance     Hybrid Journal   (Followers: 6, SJR: 0.351, h-index: 16)
Intl. J. for Ion Mobility Spectrometry     Hybrid Journal   (Followers: 1, SJR: 0.832, h-index: 13)
Intl. J. for Philosophy of Religion     Hybrid Journal   (Followers: 49, SJR: 0.275, h-index: 10)
Intl. J. for the Advancement of Counselling     Hybrid Journal   (Followers: 3, SJR: 0.266, h-index: 18)
Intl. J. for the Semiotics of Law     Hybrid Journal   (Followers: 5, SJR: 0.143, h-index: 8)
Intl. J. of Advances in Engineering Sciences and Applied Mathematics     Hybrid Journal   (Followers: 1)
Intl. J. of Anthropology     Hybrid Journal   (Followers: 17)
Intl. J. of Applied and Computational Mathematics     Hybrid Journal  
Intl. J. of Artificial Intelligence in Education     Hybrid Journal   (Followers: 3, SJR: 0.567, h-index: 13)
Intl. J. of Asian Management     Hybrid Journal   (Followers: 3)
Intl. J. of Automation and Computing     Hybrid Journal   (SJR: 0.392, h-index: 23)
Intl. J. of Automotive Technology     Hybrid Journal   (Followers: 6, SJR: 0.847, h-index: 25)
Intl. J. of Behavioral Medicine     Hybrid Journal   (Followers: 5, SJR: 0.905, h-index: 46)
Intl. J. of Biometeorology     Hybrid Journal   (Followers: 1, SJR: 0.708, h-index: 63)
Intl. J. of Cardiovascular Imaging     Hybrid Journal   (SJR: 0.858, h-index: 45)
Intl. J. of Clinical Oncology     Hybrid Journal   (Followers: 8, SJR: 0.784, h-index: 45)
Intl. J. of Clinical Pharmacy     Partially Free   (Followers: 5, SJR: 0.575, h-index: 43)
Intl. J. of Colorectal Disease     Hybrid Journal   (Followers: 10, SJR: 1.102, h-index: 69)
Intl. J. of Computer Assisted Radiology and Surgery     Hybrid Journal   (Followers: 4, SJR: 0.539, h-index: 26)
Intl. J. of Computer Vision     Hybrid Journal   (Followers: 13, SJR: 5.633, h-index: 150)
Intl. J. of Computer-Supported Collaborative Learning     Hybrid Journal   (Followers: 16, SJR: 1.641, h-index: 39)
Intl. J. of Control, Automation and Systems     Hybrid Journal   (Followers: 12, SJR: 0.644, h-index: 33)
Intl. J. of Diabetes in Developing Countries     Open Access   (Followers: 8, SJR: 0.16, h-index: 16)
Intl. J. of Disclosure and Governance     Hybrid Journal   (Followers: 7, SJR: 0.156, h-index: 11)
Intl. J. of Dynamics and Control     Hybrid Journal   (Followers: 7)
Intl. J. of Early Childhood     Hybrid Journal   (Followers: 9, SJR: 0.407, h-index: 12)
Intl. J. of Earth Sciences     Hybrid Journal   (Followers: 35, SJR: 0.992, h-index: 70)
Intl. J. of Environmental Science and Technology     Hybrid Journal   (Followers: 5, SJR: 0.576, h-index: 46)
Intl. J. of Euro-Mediterranean Studies     Hybrid Journal   (Followers: 2, SJR: 0.132, h-index: 3)
Intl. J. of Fracture     Hybrid Journal   (Followers: 12, SJR: 1.093, h-index: 68)
Intl. J. of Fuzzy Systems     Hybrid Journal  
Intl. J. of Game Theory     Hybrid Journal   (Followers: 5, SJR: 0.878, h-index: 32)
Intl. J. of Geosynthetics and Ground Engineering     Full-text available via subscription   (Followers: 4)
Intl. J. of Group Tensions     Hybrid Journal   (Followers: 1)
Intl. J. of Health Care Finance and Economics     Hybrid Journal   (Followers: 9, SJR: 0.446, h-index: 21)
Intl. J. of Hematology     Hybrid Journal   (Followers: 5, SJR: 0.779, h-index: 60)
Intl. J. of Hindu Studies     Hybrid Journal   (Followers: 11, SJR: 0.166, h-index: 5)
Intl. J. of Historical Archaeology     Hybrid Journal   (Followers: 45, SJR: 0.522, h-index: 19)
Intl. J. of Information Security     Hybrid Journal   (Followers: 32, SJR: 0.652, h-index: 27)
Intl. J. of Intelligent Transportation Systems Research     Hybrid Journal   (Followers: 9, SJR: 0.422, h-index: 6)
Intl. J. of Legal Medicine     Hybrid Journal   (Followers: 5, SJR: 1.372, h-index: 64)
Intl. J. of Machine Learning and Cybernetics     Hybrid Journal   (Followers: 9, SJR: 0.774, h-index: 20)
Intl. J. of Material Forming     Hybrid Journal   (Followers: 1, SJR: 0.504, h-index: 17)
Intl. J. of Mechanical and Materials Engineering     Open Access   (Followers: 5, SJR: 0.211, h-index: 13)
Intl. J. of Mechanics and Materials in Design     Hybrid Journal   (Followers: 6, SJR: 0.835, h-index: 15)
Intl. J. of Mental Health and Addiction     Hybrid Journal   (Followers: 17, SJR: 0.473, h-index: 22)
Intl. J. of Minerals, Metallurgy, and Materials     Hybrid Journal   (Followers: 10, SJR: 0.503, h-index: 21)
Intl. J. of Multimedia Information Retrieval     Partially Free   (Followers: 13)
Intl. J. of Occupational Medicine and Environmental Health     Hybrid Journal   (Followers: 19, SJR: 0.306, h-index: 33)
Intl. J. of Parallel Programming     Hybrid Journal   (Followers: 6, SJR: 0.255, h-index: 26)
Intl. J. of Peptide Research and Therapeutics     Partially Free   (Followers: 10, SJR: 0.329, h-index: 26)
Intl. J. of Plastics Technology     Hybrid Journal   (Followers: 1, SJR: 0.156, h-index: 4)
Intl. J. of Politics, Culture, and Society     Hybrid Journal   (Followers: 12, SJR: 0.198, h-index: 17)
Intl. J. of Precision Engineering and Manufacturing     Hybrid Journal   (Followers: 8, SJR: 0.659, h-index: 25)
Intl. J. of Precision Engineering and Manufacturing-Green Technology     Hybrid Journal   (SJR: 1.316, h-index: 7)
Intl. J. of Primatology     Hybrid Journal   (Followers: 6, SJR: 1.078, h-index: 59)
Intl. J. of Public Health     Hybrid Journal   (Followers: 19, SJR: 1.21, h-index: 41)
Intl. J. of Rehabilitation and Health     Hybrid Journal   (Followers: 17)
Intl. J. of Salt Lake Research     Hybrid Journal   (Followers: 2)
Intl. J. of Science and Mathematics Education     Hybrid Journal   (Followers: 22, SJR: 0.851, h-index: 20)
Intl. J. of Self-Propagating High-Temperature Synthesis     Hybrid Journal   (Followers: 2, SJR: 0.304, h-index: 5)
Intl. J. of Sexuality and Gender Studies     Hybrid Journal   (Followers: 24)
Intl. J. of Social Robotics     Hybrid Journal   (Followers: 3, SJR: 1.198, h-index: 22)
Intl. J. of Speech Technology     Hybrid Journal   (Followers: 8, SJR: 0.295, h-index: 19)
Intl. J. of Steel Structures     Hybrid Journal   (Followers: 2, SJR: 0.557, h-index: 8)
Intl. J. of Stomatology & Occlusion Medicine     Hybrid Journal  
Intl. J. of Systems Assurance Engineering and Management     Hybrid Journal   (SJR: 0.291, h-index: 10)
Intl. J. of Technology and Design Education     Hybrid Journal   (Followers: 13, SJR: 0.573, h-index: 24)
Intl. J. of the Classical Tradition     Hybrid Journal   (Followers: 7, SJR: 0.111, h-index: 3)
Intl. J. of Theoretical Physics     Hybrid Journal   (Followers: 18, SJR: 0.399, h-index: 44)
Intl. J. of Thermophysics     Hybrid Journal   (Followers: 5, SJR: 0.431, h-index: 50)
Intl. J. of Wireless Information Networks     Hybrid Journal   (Followers: 5, SJR: 0.229, h-index: 22)
Intl. J. on Digital Libraries     Hybrid Journal   (Followers: 591, SJR: 0.375, h-index: 28)
Intl. J. on Document Analysis and Recognition (IJDAR)     Hybrid Journal   (Followers: 2, SJR: 0.546, h-index: 38)
Intl. J. on Interactive Design and Manufacturing (IJIDeM)     Hybrid Journal   (Followers: 3, SJR: 0.299, h-index: 12)
Intl. J. on Software Tools for Technology Transfer (STTT)     Hybrid Journal   (Followers: 5, SJR: 0.806, h-index: 41)
Intl. Ophthalmology     Hybrid Journal   (Followers: 4, SJR: 0.526, h-index: 33)
Intl. Orthopaedics     Hybrid Journal   (Followers: 15, SJR: 1.508, h-index: 59)
Intl. Politics     Hybrid Journal   (Followers: 29, SJR: 0.378, h-index: 22)
Intl. Politics Reviews     Hybrid Journal   (Followers: 4)
Intl. Review of Economics     Hybrid Journal   (Followers: 5, SJR: 0.165, h-index: 8)
Intl. Review of Education     Hybrid Journal   (Followers: 10, SJR: 0.369, h-index: 22)
Intl. Review on Public and Nonprofit Marketing     Hybrid Journal   (Followers: 2, SJR: 0.216, h-index: 6)
Intl. Sports Law J.     Hybrid Journal   (Followers: 3, SJR: 0.16, h-index: 1)
Intl. Tax and Public Finance     Hybrid Journal   (Followers: 8, SJR: 0.799, h-index: 37)
Intl. Urogynecology J.     Hybrid Journal   (Followers: 5, SJR: 0.955, h-index: 72)
Intl. Urology and Nephrology     Hybrid Journal   (Followers: 5, SJR: 0.506, h-index: 38)
Inventiones mathematicae     Hybrid Journal   (Followers: 1, SJR: 5.874, h-index: 75)
Invertebrate Neuroscience     Hybrid Journal   (Followers: 3, SJR: 0.566, h-index: 28)
Investigational New Drugs     Hybrid Journal   (Followers: 10, SJR: 1.376, h-index: 68)
Ionics     Hybrid Journal   (Followers: 2, SJR: 0.486, h-index: 36)
Iranian Polymer J.     Hybrid Journal   (Followers: 4, SJR: 0.517, h-index: 28)
Irish J. of Medical Science     Hybrid Journal   (Followers: 1, SJR: 0.298, h-index: 23)
Irrigation and Drainage Systems     Hybrid Journal   (Followers: 3)
Irrigation Science     Hybrid Journal   (Followers: 4, SJR: 1.193, h-index: 46)
Israel J. of Mathematics     Hybrid Journal   (Followers: 1, SJR: 1.649, h-index: 40)
Italian Economic J.     Hybrid Journal   (Followers: 27)
Izvestiya Atmospheric and Oceanic Physics     Hybrid Journal   (Followers: 3, SJR: 0.279, h-index: 17)
Izvestiya, Physics of the Solid Earth     Hybrid Journal   (Followers: 2, SJR: 0.394, h-index: 13)
J. Africain d'Hépato-Gastroentérologie     Hybrid Journal   (Followers: 2, SJR: 0.142, h-index: 3)
J. africain du cancer / African J. of Cancer     Hybrid Journal   (Followers: 2, SJR: 0.188, h-index: 4)
J. d'Analyse Mathématique     Hybrid Journal   (Followers: 3, SJR: 1.973, h-index: 36)
J. for General Philosophy of Science     Hybrid Journal   (Followers: 6, SJR: 0.207, h-index: 10)
J. for Labour Market Research     Hybrid Journal   (Followers: 8)
J. fur Asthetische Chirurgie     Hybrid Journal   (SJR: 0.117, h-index: 4)
J. für Betriebswirtschaft     Hybrid Journal   (Followers: 1, SJR: 0.195, h-index: 9)
J. für Mathematik-Didaktik     Hybrid Journal   (SJR: 0.226, h-index: 7)
J. für Rechtspolitik     Hybrid Journal  
J. für Verbraucherschutz und Lebensmittelsicherheit     Hybrid Journal   (SJR: 0.221, h-index: 17)
J. of Abnormal Child Psychology     Hybrid Journal   (Followers: 7, SJR: 2.03, h-index: 107)
J. of Academic Ethics     Hybrid Journal   (Followers: 4, SJR: 0.395, h-index: 10)
J. of Acupuncture and Tuina Science     Hybrid Journal   (Followers: 3, SJR: 0.216, h-index: 6)
J. of Adult Development     Hybrid Journal   (Followers: 7, SJR: 0.463, h-index: 30)
J. of Advancement in Medicine     Hybrid Journal  
J. of African American Studies     Hybrid Journal   (Followers: 8, SJR: 0.155, h-index: 8)
J. of Aging and Identity     Hybrid Journal   (Followers: 8)
J. of Agricultural and Environmental Ethics     Hybrid Journal   (Followers: 7, SJR: 0.508, h-index: 32)
J. of Agricultural, Biological & Environmental Statistics     Hybrid Journal   (Followers: 10, SJR: 0.571, h-index: 39)
J. of Algebraic Combinatorics     Hybrid Journal   (Followers: 2, SJR: 1.436, h-index: 27)
J. of Ambient Intelligence and Humanized Computing     Hybrid Journal   (SJR: 0.456, h-index: 11)
J. of Analytical Chemistry     Hybrid Journal   (Followers: 21, SJR: 0.268, h-index: 23)
J. of Analytical Science & Technology     Open Access   (Followers: 6)
J. of Anesthesia     Hybrid Journal   (Followers: 11, SJR: 0.513, h-index: 30)
J. of Applied and Industrial Mathematics     Hybrid Journal   (SJR: 0.176, h-index: 8)
J. of Applied Electrochemistry     Hybrid Journal   (Followers: 12, SJR: 0.676, h-index: 86)
J. of Applied Genetics     Partially Free   (Followers: 1, SJR: 0.621, h-index: 38)
J. of Applied Mathematics and Computing     Hybrid Journal   (SJR: 0.483, h-index: 24)
J. of Applied Mechanics and Technical Physics     Hybrid Journal   (Followers: 7, SJR: 0.199, h-index: 13)
J. of Applied Phycology     Hybrid Journal   (Followers: 10, SJR: 0.852, h-index: 73)
J. of Applied Spectroscopy     Hybrid Journal   (Followers: 9, SJR: 0.18, h-index: 15)
J. of Archaeological Method and Theory     Hybrid Journal   (Followers: 62, SJR: 1.464, h-index: 34)
J. of Archaeological Research     Hybrid Journal   (Followers: 54, SJR: 1.681, h-index: 36)
J. of Arid Land     Hybrid Journal   (Followers: 1, SJR: 0.56, h-index: 9)
J. of Artificial Organs     Hybrid Journal   (SJR: 0.66, h-index: 29)
J. of Asset Management     Partially Free   (Followers: 2, SJR: 0.181, h-index: 6)
J. of Assisted Reproduction and Genetics     Hybrid Journal   (Followers: 4, SJR: 0.858, h-index: 57)
J. of Astrophysics and Astronomy     Open Access   (Followers: 40, SJR: 0.226, h-index: 19)
J. of Atmospheric Chemistry     Hybrid Journal   (Followers: 21, SJR: 0.599, h-index: 59)
J. of Autism and Developmental Disorders     Hybrid Journal   (Followers: 39, SJR: 1.877, h-index: 123)
J. of Automated Reasoning     Hybrid Journal   (SJR: 1.63, h-index: 43)
J. of Banking Regulation     Hybrid Journal   (Followers: 24, SJR: 0.16, h-index: 7)
J. of Behavioral Education     Hybrid Journal   (Followers: 4, SJR: 0.763, h-index: 28)
J. of Behavioral Health Services & Research     Hybrid Journal   (Followers: 13, SJR: 0.555, h-index: 41)
J. of Behavioral Medicine     Hybrid Journal   (Followers: 3, SJR: 1.069, h-index: 73)
J. of Bio- and Tribo-Corrosion J. of Bio- and Tribo-Corrosion     Hybrid Journal  
J. of Bioeconomics     Hybrid Journal   (Followers: 1, SJR: 0.391, h-index: 18)
J. of Bioenergetics and Biomembranes     Hybrid Journal   (Followers: 1, SJR: 1.092, h-index: 83)
J. of Bioethical Inquiry     Hybrid Journal   (Followers: 3, SJR: 0.396, h-index: 13)
J. of Biological Physics     Hybrid Journal   (SJR: 0.481, h-index: 33)
J. of Biomedical Science     Open Access   (Followers: 4, SJR: 1.28, h-index: 59)
J. of Biomolecular NMR     Hybrid Journal   (Followers: 7, SJR: 2.043, h-index: 89)
J. of Biorheology     Hybrid Journal   (SJR: 0.122, h-index: 7)
J. of Biosciences     Open Access   (SJR: 0.841, h-index: 54)
J. of Bone and Mineral Metabolism     Hybrid Journal   (Followers: 3, SJR: 0.775, h-index: 56)
J. of Brand Management     Hybrid Journal   (Followers: 16, SJR: 0.535, h-index: 22)
J. of Business and Psychology     Hybrid Journal   (Followers: 7, SJR: 1.385, h-index: 46)
J. of Business Economics     Hybrid Journal   (Followers: 6)
J. of Business Ethics     Hybrid Journal   (Followers: 34, SJR: 1.358, h-index: 98)
J. of Cachexia, Sarcopenia and Muscle     Open Access   (Followers: 2, SJR: 1.955, h-index: 26)
J. of Cancer Education     Hybrid Journal   (Followers: 3, SJR: 0.525, h-index: 33)
J. of Cancer Research and Clinical Oncology     Hybrid Journal   (Followers: 15, SJR: 1.19, h-index: 76)
J. of Cancer Survivorship     Hybrid Journal   (Followers: 2, SJR: 2, h-index: 34)
J. of Cardiovascular Translational Research     Hybrid Journal   (Followers: 1, SJR: 1.567, h-index: 32)
J. of Cell Communication and Signaling     Hybrid Journal   (SJR: 1.195, h-index: 27)
J. of Central South University     Hybrid Journal   (Followers: 1, SJR: 0.335, h-index: 20)
J. of Chemical Biology     Hybrid Journal   (Followers: 1, SJR: 0.685, h-index: 14)
J. of Chemical Crystallography     Hybrid Journal   (Followers: 2, SJR: 0.25, h-index: 28)
J. of Chemical Ecology     Hybrid Journal   (Followers: 6, SJR: 1.559, h-index: 88)
J. of Chemical Sciences     Partially Free   (Followers: 17, SJR: 0.322, h-index: 37)
J. of Child and Adolescent Group Therapy     Hybrid Journal   (Followers: 2)
J. of Child and Family Studies     Hybrid Journal   (Followers: 20, SJR: 0.549, h-index: 50)
J. of Children's Orthopaedics     Hybrid Journal   (Followers: 9, SJR: 0.584, h-index: 18)
J. of Chinese Political Science     Hybrid Journal   (Followers: 7, SJR: 0.515, h-index: 9)
J. of Chinese Sociology     Open Access   (Followers: 2)
J. of Civil Structural Health Monitoring     Hybrid Journal   (Followers: 4, SJR: 0.296, h-index: 7)
J. of Classification     Hybrid Journal   (Followers: 7, SJR: 0.968, h-index: 29)
J. of Clinical Geropsychology     Hybrid Journal   (Followers: 1)
J. of Clinical Immunology     Hybrid Journal   (Followers: 14, SJR: 1.332, h-index: 75)
J. of Clinical Monitoring and Computing     Hybrid Journal   (Followers: 1, SJR: 0.661, h-index: 37)
J. of Clinical Psychology in Medical Settings     Hybrid Journal   (Followers: 12, SJR: 0.46, h-index: 34)
J. of Cluster Science     Hybrid Journal   (SJR: 0.416, h-index: 31)

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Journal Cover Neurophysiology
  [SJR: 0.168]   [H-I: 9]   [1 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1573-9007 - ISSN (Online) 0090-2977
   Published by Springer-Verlag Homepage  [2345 journals]
  • Ethical Responsibilities of the Authors
    • PubDate: 2017-06-05
      DOI: 10.1007/s11062-017-9622-1
       
  • Hypothermic Suppression of Epileptiform Bursting Activity of a Hyppocampal
           Granule Neuron Possessing Thermosensitive TRP Channels (a Model Study:
           Biophysical and Clinical Aspects)
    • Authors: L. E. Demianenko; E. P. Poddubnaya; I. A. Makedonsky; I. B. Kulagina; S. M. Korogod
      Abstract: Synchronous burst discharges of action potentials (APs) of neurons are typical manifestations of cerebral epileptiform activity; such discharges are reflected in EEG as burst-suppression episodes. For elimination of drug-resistant epileptogenic foci, therapeutic hypothermia (controlled decrease in the body temperature) is increasingly used; at the same time, the mechanisms of its therapeutic effect remain largely unknown. We investigated one of the respective possible mechanisms on a model of the granule neuron (GN) of the hippocampal dentate gyrus. These cells are the first links in three-synaptic neuronal chains of the hippocampus; the latter is the brain region where sources of epileptiform activity are often localized. In the somatodendritic membrane of the GN model, thermosensitive channels of the TRP family, which conduct a depolarizing current, were included along with other ion channels inherent in these neurons. It has been found that such channels are indeed expressed in GNs. In response to tonic synaptic excitation uniformly distributed over the dendrites, the GN at 37°C (normothermia) generated periodic multipulse burst discharges. Lowering the temperature to 36, 34, 32, and 30°C (borders of weak, moderate, moderately deep, and deep therapeutic hypothermia, respectively) led to degradation of the bursting patterns and their transformation into low-frequency trains of separate APs. Precisely at these temperatures, is the depolarizing current through TRP channels deactivated. The phenomenon of degradation of bursting activity generated by the model GN corresponded to a multifold decrease in the amplitude, duration, and repetition frequency of the burst-suppression episodes in EEGs of newborn infants suffering from hypoxic-ischemic CNS injury, which we observed in clinics under conditions of moderate hypothermia (34°C) used for treatment of such patients. These observations allow us to suggest that hypothermic suppression of bursting discharges of hippocampal neurons possessing thermosensitive TRP channels may be one of the mechanisms of the therapeutic effect of hypothermia.
      PubDate: 2017-06-02
      DOI: 10.1007/s11062-017-9624-z
       
  • Erratum to: Parameters of the P300 Potential in Mild Neurocognitive
           Disorders of Different Etiologies
    • Authors: O. V. Levada; N. V. Cherednichenko; S. V. Gorbachev
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9635-9
       
  • Contrast-Dependent Restructuring of Neuronal Visual Receptive Fields in
           the Cat Extrastriate Cortex
    • Authors: B. A. Harutiunian-Kozak; A. L. Ghazaryan; M. M. Momjian; D. K. Khachvankian; H. R. Aslanian
      Abstract: Spatial modifications of neuronal visual receptive fields (RFs) in the cat extrastriate cortex were studied. The response properties and spatial organization of the RFs of area 21a neurons were investigated using visual stimuli of two opposite contrasts, with particular attention to the stationary structure of these RFs. It was found that the infrastructure of the RF of a visually sensitive neuron undergoes certain restructuring related to the contrast of the visual stimuli used. In most cases, discharge centers of the RF subfields changed their response profile and spatial localization within the RF depending on the stimulus contrast. Stationary RFs defined by presentation of flashing spots of two opposite contrasts (bright and dark) differed from each other quantitatively and qualitatively, indicating the influence of background illumination on the pattern of neuronal responses. It is hypothesized that the RF surrounding significantly influences central processing of incoming visual information and image recognition in the extrastriate cortex.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9627-9
       
  • Effects of Stereotactic Introduction of Baclofen in the Medullary
           Cardiovascular Nuclei of Rats
    • Authors: L. M. Shapoval; O. V. Dmytrenko; A. M. Naumenko; T. L. Davydovska; V. F. Sagach
      Abstract: In rats anesthetized with urethane (1.7 g/kg, i. p.), we investigated the effects of stereotaxic microinjections of baclofen into the medullary nuclei involved in the neural control of cardiovascular activity (nuclei paramedianus, ambiguus, and reticularis lateralis). Changes in the hemodynamic parameters (systolic and diastolic blood pressure and heart rate) were measured. Injections of the above GABAB receptor agonist (10–7, 10–6, or 10–5 M, 0.1 μl) into the medullary cardiovascular nuclei was accompanied by changes in the blood pressure, the magnitude and direction of which depended not only on the baclofen concentration but also on the site of injection (into one nucleus or another). Injections of the agent into the nucl. ambiguus at a 10–7 M concentration resulted in an increase in the blood pressure, but a 10–5 M concentration provided significant reduction of the systolic and diastolic blood pressure. If baclofen was injected into the nucl. reticularis lat., the blood pressure also increased or decreased but the concentration dependence was opposite to the above described. Injections of the agent into the nucl. paramedianus were always accompanied by significant increases in the blood pressure. Changes in the heart rate following baclofen injections into the nuclei under study were insignificant. The specificities of the baclofen-induced effects are probably related to peculiarities of the functioning of GABAB receptors, the activation of which may mediate the effects of multiple neuronal mechanisms.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9626-x
       
  • Effect of Night Shift-Related Tiredness on Eye Saccades
    • Authors: A. Skrzypek; M. Szeliga; K. Jabłoński; M. Nowakowski
      Abstract: Parameters of saccades (latency, amplitude, duration, and velocity) were measured using a saccadometer in 32 nurses (30 women and 2 men) before and after a night shift. The mean latency of saccades was found to significantly increase after this period (209.6 ± 6.84 vs. 188.6 ± 6.08 msec, P = 0.002); the same was found with respect to the saccade duration (55.0 ± 0.97 vs. 54.2 ± 1.23 msec, P < 0.05). Thus, stress and sleep deprivation noticeably influence the parameters of saccades; the latter, nonetheless, remain within a physiological range. Considering that a number of brain structures are involved in the control of saccade parameters, the above-described modulations of saccades can be potentially used as generalized indices characterizing the level of brain tiredness.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9633-y
       
  • Effects of Hindbrain Infusion of an Estrogen Receptor Antagonist on
           Estrogenic Modulation of Eating Behavior
    • Authors: S. Thammacharoen; P. Kitchanukitwattana; P. Suwanapaporn; N. Chaiyabutr
      Abstract: Estradiol (E2) inhibits eating behavior in females via activating estrogen receptors (ERs) within the brain. Activation of hindbrain ERαs has been shown to be sufficient to inhibit eating behavioral pattern. To investigate the involvement of hindbrain ERαs in estrogenic control of eating behavior, intracerebroventricular infusion (4th i.c.v.) of an estrogen receptor antagonist, ICI 182780 (ICI), was performed in ovariectmized female rats. Significantly lower daily food intake was observed in rats after estradiol benzoate (EB) injections. The effect of EB on food intake was significantly compromised by 4th i.c.v. infusions of both 4 and 8 nM ICI solutions. The results suggest that hindbrain infusions of ICI can significantly attenuate the inhibitory effect of E2 on food intake. Importantly, 4th i.c.v. infusions during 12 days exerted no effect per se on eating. Further, there was no difference in the number of ERα immunopositive neurons in the selected hypothalamic nuclei and nucl. tractus solitarius. We conclude that the 4th i.c.v. infusions with ICI attenuated the exogenous estrogenic effect on food intake in ovariectomized rats, and the hindbrain is an important site pro viding estrogenic control of food intake.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9631-0
       
  • Movement-Dependent Spatial Expansion of Visual Receptive Fields of Neurons
           of the Extrastriate Cortex
    • Authors: H. R. Aslanian; A. P. Antonian; B. A. Harutiunian-Kozak; A. V. Khachatryan; A. L. Ghazaryan; J. A. Kozak; D. K. Khachvankian
      Abstract: The spatial structure of the receptive field (RF) of a visually sensitive neuron, as defined by presentation of stationary visual stimuli, predetermines in most cases central processing of visual information concerning moving visual images. In our study, properties of a group of neurons in the extrastriate cortical area 21a (≈18% of the examined sampling) with extremely small RF sizes (≈1.5 deg2) determined by stationary visual stimuli were investigated. It was found that spatial dimensions of each neuronal RFs may undergo manifold expansions; the neuronal response profiles depended strongly on the size, shape, and contrast of the applied moving stimuli. As a result, a high degree of diversification of neuronal response patterns depending of the shapes and contrasts of applied moving stimuli was observed. These data confirm the suggestion that the RFs of neurons in the extrastriate area 21a undergo temporary dynamic changes due to activation of surrounding neuronal groups/networks by moving visual stimuli. Thus, it is evident that processing of visual information in the course of visual image recognition is realized by integrated activity of a complex of the corresponding cortical networks of visually sensitive neurons.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9628-8
       
  • Vasyl’ M. Moroz – 75 years
    • PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9634-x
       
  • Computer Simulation of Molecular Interaction Between Baclofen and the GABA
           B Receptor
    • Authors: A. M. Naumenko; L. M. Shapoval; A. Yu. Nyporko; M. I. Voiteshenko; A. V. Tsymbalyuk; V. F. Sagach; T. L. Davydovska
      Abstract: In our previous work [1], we have reconstructed the spatial structure of a full-size GABAB receptor using computer simulation. Considering the fact that baclofen is a selective agonist of this receptor, we attempted to search for binding sites of the molecule of this agent with the extracellular domain of a GABAB1 receptor subunit, assessed the molecular dynamics of their interaction, and calculated the energy of nonvalent interactions between the receptor and agonist molecule under study. A molecular docking approach used to estimate interactions between baclofen and the GABAB receptor extracellular domain allowed us to choose three sites for possible binding of the baclofen molecule to the receptor. Using molecular dynamics simulation, we identified two sites capable of providing stable coupling of baclofen with the GABAB receptor.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9623-0
       
  • Short- and Long-Term Effects of Methylphenidate on Cost-Benefit Decision
           Making in Adult Rats
    • Authors: S. Daniali; H. Manaheji; V. Nazemian; M. Taheri
      Abstract: Decision making is one of the most complicated and controversial topics in neuroscience. Today, there are important classes of chemicals that increase cognitive performance; in particular these are psychostimulants (e.g., methylphenidate, MPH). However, the long-term effects of MPH on cost-benefit decision making in healthy animals remain unknown. Therefore, we aimed to compare the short- and long-term effects of MPH in adult healthy male rats on the decision making in two distinct T-maze tasks and the ability of the animals to adjust the height of the obstacle in a T-maze or to process information on the reward amount. We found that short-term effects of MPH (2 weeks) played a significant role in making the correct decision in T-maze tasks, while the respective effects of long-term administration (12 weeks) were much weaker. These data suggest that chronic application of MPH has short- but not long-term effects on cost-benefit decision making in healthy adult animals.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9629-7
       
  • GABA A Receptors: Involvement in the Formation of Respiratory Reactions to
           Hypoxic Stimulation under Conditions of Mitochondrial Dysfunction
    • Authors: E. É. Kolesnikova
      Abstract: In experiments on Wistar rats, the role of the state of GABAA receptors in the formation of respiratory responses to hypoxic loading was studied under conditions of the norm and experimental mitochondrial dysfunction; the latter was induced by single systemic injections of 3 mg/kg rotenone, a nonselective blocker of complex I in the respiratory chain of the mitochondria. Volume-time parameters of respiration were characterized according to the parameters of respiratory EMG discharges of the diaphragmatic muscle (amplitude, frequency, and integral intensity). Changes in EMG activity of the diaphragm induced by inhalation of a hypoxic gas mixture (12% О2 + 88% N2) were estimated prior to and after injections of the blocker of GABAA and GABAB receptors bicuculline (bicuculline methiodide, 1.0 mg/kg) in control rats and animals with mitochondrial dysfunction. The development of mitochondrial dysfunction was accompanied by suppression of the respiratory reaction to hypoxic loading, which was manifested in a dramatic decrease in the frequency and integral intensity of EMG discharges of the diaphragmatic muscle. These data can be considered an indication of the considerable involvement of GABAA receptors localized at the postsynaptic membranes of peripheral chemoreceptors in the formation of respiratory response to hypoxic stimulation (including the stage of depression of ventilation); this was observed in both control rats and animals with mitochondrial dysfunction. The involvement of a GABA-ergic link in the formation of respiratory activity related to hypoxic stimulation acquires special significance under conditions of experimental mitochondrial dysfunction leading to occlusion of afferent impulsation coming from peripheral chemoreceptors.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9625-y
       
  • Features of EEG Activity Related to Realization of Cyclic Unimanual and
           Bimanual Hand Movements in Humans
    • Authors: T. Tomiak; A. V. Gorkovenko; V. S. Mishchenko; D. A. Vasilenko
      Abstract: In 10 tested dextral subjects, EEG activity was recorded during the performance of unimanual and bimanual cyclic movements of the hands and fingers. The movements corresponded to clenching the fingers into a fist and the subsequent unclenching of the fingers. The test consisted of four successive stages, the resting state, movement of the left hand, that of the right hand, and movement of both hands. The dependences between the spectral power and coherence of the respective EEG samples on the type of the test performed, on the type of the movement (uni- or bimanual), and on the laterality of the latter in the case of the unimanual movement were examined. The results obtained allow us to propose the following conclusions: (i) α and β EEG rhythms are characterized by different functional importance with respect to manual motor activity; (ii) neural control of bimanual movements cannot be considered “a sum of the controls” of unimanual movements, and (iii) control of bimanual movements may be largely based on the control of the movement by a subdominant upper limb.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9632-z
       
  • Decision-Level Fusion-Based Structure of Autism Diagnosis Using
           Interpretation of EEG Signals Related to Facial Expression Modes
    • Authors: M. Hashemian; H. Pourghassem
      Abstract: A structure of decision-level fusion-based autism diagnosis using analysis of EEG signals related to presentation of facial expression modes has been proposed. EEG signals of autistic and normal children were recorded during processing images of emotional facial expression modes, such as sadness, happiness, and calmness. Then brain signals were mapped into the feature space by applying a novel hybrid model utilizing the brain potentials recorded during the examination task. The aim of mapping was to achieve separation of the autistic samples from normal ones with the highest precision. The created map provides the feature vectors that reflected spatial, temporal, and spectral data, as well as the coherence degrees for distinct areas of the brain. The mapping process was optimized using a genetic algorithm by assigning weighs to the feature vectors. Then the feature vectors corresponding to the three facial expressions of emotional modes were classified by support vector machines. Finally, using decision-level fusion through a majority voting rule, we see that the proposed structure is able to effectively distinguish the autistic individuals from normal ones.
      PubDate: 2017-06-01
      DOI: 10.1007/s11062-017-9630-1
       
  • Ethical Responsibilities of the Authors
    • PubDate: 2017-03-30
      DOI: 10.1007/s11062-017-9614-1
       
  • Features of the EEG Spectral Composition in Patients with
           Cervicocranialgias and Dorsalgias of Different Origin
    • Authors: I. A. Nazarchuk; V. I. Sukhorukov; L. P. Zabrodina; S. V. Fedoseyev
      Abstract: We examined the spectral composition of ongoing EEG activity in 77 patients suffering from intense pain in the neck and/or back (cervicocranialgia and/or dorsalgia) caused by neurological vertebral disorders of reflex origin (group VDRO, n = 43), multiple sclerosis (group MS, n = 17), and consequences of earlier neuroinfections (group NIC, n = 17). Visual analysis of EEG records of these patients showed the existence of disorganized EEG patterns more intensely manifested in the latter two groups. Spectral EEG analysis demonstrated that the averaged spectral powers (SPs) of β1 and β2 oscillations in patients of group MS were, in almost all EEG leads, significantly greater than those in subjects of groups VDRO and NIC, while the SP of θ activity in most cortical loci (except frontal ones) was significantly lower. The SP of the β1 and β2 subrhythms demonstrated significant negative correlations with the frequency of pain attacks in the VDRO group. At the same time, the power of this subrhythm in the MS group showed close positive correlations with the pain intensity, while these indices in the group NIC correlated with the frequency of pain attacks. The increased power of high-frequency components of ongoing EEG can be considered an EEG correlate of dorsalgials and cervicocranialgias in MS patients.
      PubDate: 2017-03-30
      DOI: 10.1007/s11062-017-9617-y
       
  • Gender Specificity of Genistein Treatment in Penicillin-Induced
           Epileptiform Activity in Rats
    • Authors: A. Bahadir; S. Demir; H. Orallar; E. Beyazcicek; A. Cetinkaya; S. Ankarali; H. Ankarali
      Abstract: We investigated gender-dependent differences of genistein (isoflavone phytoestrogen) treatment in a penicillin-induced experimental epilepsy rat model. Twenty-eight adult Wistar Albino rats (14 females and 14 males) were devided into four groups, control and genistein-treatmed males and females. Genistein (100 μg/kg, i.p) or saline was given during 15 days before the electrocorticography (ECoG) recordings. The epileptiform activity was induced by penicillin G potassium salt (500 IU) injections into the left somatomotor cortex. Significant differences among the groups were found in the latency to onset of epileptiform activity. This value in the female control group was significantly longer than the latencies in the male control, male genistein, and female genistein groups (respectively, P = 0.002, 0.015, and 0.032). There were no significant differences regarding the spike/wave frequencies and amplitudes in epileptiform activity between female/male genistein and control groups within all observation intervals (P > 0.05). Thus, genistein exerts a proconvulsant effect in the penicillin-induced epilepsy model, and the effect demonstrates the clear gender specificity related to the specificity of hormonal backgrounds in males and females.
      PubDate: 2017-03-30
      DOI: 10.1007/s11062-017-9619-9
       
  • Parameters of the P300 Potential in Mild Neurocognitive Disorders of
           Different Etiologies
    • Authors: O. V. Levada; N. V. Cherednichenko; S. V. Gorbachev
      Abstract: The latency and amplitude of the auditory evoked Р300 potential were measured in 25 elderly and old persons without any cognitive impairments (control group), 32 patients with mild neurocognitive disorder induced by Alzheimer’s disease (AD MNCD), and 33 patients with analogous impairment of subcortical vascular genesis (SCV MNCD). The examined groups did not differ from each other significantly in age, sex, and educational level. It was found that the mean latency of the Р300 wave in patients suffering from SCV MNCD (507.9 ± 203.6 msec) was significantly longer as compared with the analogous parameter in two other groups. The value of such increment allows one to differentiate SCV MNCD from the groups without cognitive impairment (326.9 ± 103.6 msec, Р = 0.00005) and AD MNCD (378.9 ± 99.9 msec Р = 0.0007). The increased P300 latency is related to the severity and clinical specificity of SCV MNCD and reflects a crucial influence of the microvascular cerebral frontosubcortical injury on the generation of this neurophysiological phenomenon. We conclude that the level of increase in the latency of wave Р300 can be used as a valid neurophysiological marker for differential diagnostics of MNCDs of the main etiological types.
      PubDate: 2017-03-30
      DOI: 10.1007/s11062-017-9618-x
       
  • Morphofunctional Modifications of Neurocytes of the Rat Hippocampal CA3
           Area after Experimental Thermal Trauma
    • Authors: S. O. Lytvynyuk; K. S. Volkov; Z. M. Nebesna
      Abstract: In experiments on mature male Wistar rats, the dynamics of morphological modifications of neurocytes of the hippocampal CA3 area after a severe thermal trauma were examined. The pattern and degree of morphofunctional changes in the nerve cells depended significantly on the time interval after thermal trauma; their intensity correlated with the stages of burn disease. At stages of acute shock and early toxemia (days 1 to 7), mostly effects that could be interpreted as adaptive/compensatory reactions were observed, although initial signs of destructive changes were also obvious. At stages of late toxemia and septicotoxemia (days 14 to 21), deep irreversible destructive modifications in a considerable part of neurocytes of the hippocampal CA3 area became appreciable. The proportions of neurocytes belonging to different morphological types and values of the nucleo-cytoplasmic ratio (NCR) in such cells changed significantly. After an experimental burn, the total density of neurocytes gradually decreased, while portions of sharply hypo- and hyperchromic cells, in which NCRs underwent maximum modifications, increased. Electron microscopy of CA3 nerve cell demonstrated the development of destructive changes in the nuclei and cytoplasmic structures (degranulation of the endoplasmic reticulum, decrease in the number of ribosomes and polysomes, hypertrophy of the mitochondria with clarification of their matrix and destruction of mitochondrial cristae, and increase in the number of lysosomes). Therefore, severe thermal trauma induces significant morphofunctional modifications of neurocytes in the hippocampal CA3 area.
      PubDate: 2017-03-30
      DOI: 10.1007/s11062-017-9616-z
       
  • To the 130th Anniversary of the Birth of Academician Daniil Vorontsov.
           Vorontsov’s Scientific Concepts: Past, Present, and Future of
           Neuroscience in Ukraine
    • Authors: I. S. Magura; N. A. Bogdanova
      PubDate: 2017-03-30
      DOI: 10.1007/s11062-017-9621-2
       
 
 
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