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Publisher: Springer-Verlag   (Total: 2341 journals)

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Showing 1001 - 1200 of 2341 Journals sorted alphabetically
Interactive Surgery     Hybrid Journal  
Interchange     Hybrid Journal   (Followers: 1, SJR: 0.131, h-index: 13)
Interdisciplinary Sciences : Computational Life Sciences     Hybrid Journal   (Followers: 2, SJR: 0.294, h-index: 10)
Intereconomics     Hybrid Journal   (Followers: 1, SJR: 0.195, h-index: 12)
Interest Groups & Advocacy     Hybrid Journal   (Followers: 1)
Internal and Emergency Medicine     Hybrid Journal   (Followers: 1, SJR: 0.757, h-index: 27)
Intl. Advances in Economic Research     Hybrid Journal   (Followers: 6, SJR: 0.155, h-index: 16)
Intl. Applied Mechanics     Hybrid Journal   (Followers: 3, SJR: 0.248, h-index: 31)
Intl. Archives of Occupational and Environmental Health     Hybrid Journal   (Followers: 7, SJR: 0.973, h-index: 69)
Intl. Cancer Conference J.     Hybrid Journal  
Intl. Commerce Review     Hybrid Journal   (Followers: 1)
Intl. Communication of Chinese Culture     Hybrid Journal   (Followers: 5)
Intl. Economics and Economic Policy     Hybrid Journal   (Followers: 3, SJR: 0.181, h-index: 14)
Intl. Entrepreneurship and Management J.     Hybrid Journal   (Followers: 8, SJR: 0.489, h-index: 27)
Intl. Environmental Agreements: Politics, Law and Economics     Hybrid Journal   (Followers: 12, SJR: 0.706, h-index: 24)
Intl. J. for Educational and Vocational Guidance     Hybrid Journal   (Followers: 6, SJR: 0.351, h-index: 16)
Intl. J. for Ion Mobility Spectrometry     Hybrid Journal   (Followers: 1, SJR: 0.832, h-index: 13)
Intl. J. for Philosophy of Religion     Hybrid Journal   (Followers: 46, SJR: 0.275, h-index: 10)
Intl. J. for the Advancement of Counselling     Hybrid Journal   (Followers: 3, SJR: 0.266, h-index: 18)
Intl. J. for the Semiotics of Law     Hybrid Journal   (Followers: 5, SJR: 0.143, h-index: 8)
Intl. J. of Advances in Engineering Sciences and Applied Mathematics     Hybrid Journal   (Followers: 1)
Intl. J. of Anthropology     Hybrid Journal   (Followers: 17)
Intl. J. of Applied and Computational Mathematics     Hybrid Journal  
Intl. J. of Artificial Intelligence in Education     Hybrid Journal   (Followers: 3, SJR: 0.567, h-index: 13)
Intl. J. of Asian Management     Hybrid Journal   (Followers: 3)
Intl. J. of Automation and Computing     Hybrid Journal   (SJR: 0.392, h-index: 23)
Intl. J. of Automotive Technology     Hybrid Journal   (Followers: 6, SJR: 0.847, h-index: 25)
Intl. J. of Behavioral Medicine     Hybrid Journal   (Followers: 6, SJR: 0.905, h-index: 46)
Intl. J. of Biometeorology     Hybrid Journal   (Followers: 1, SJR: 0.708, h-index: 63)
Intl. J. of Cardiovascular Imaging     Hybrid Journal   (SJR: 0.858, h-index: 45)
Intl. J. of Clinical Oncology     Hybrid Journal   (Followers: 9, SJR: 0.784, h-index: 45)
Intl. J. of Clinical Pharmacy     Partially Free   (Followers: 5, SJR: 0.575, h-index: 43)
Intl. J. of Coal Science & Technology     Open Access   (Followers: 1)
Intl. J. of Colorectal Disease     Hybrid Journal   (Followers: 10, SJR: 1.102, h-index: 69)
Intl. J. of Computer Assisted Radiology and Surgery     Hybrid Journal   (Followers: 4, SJR: 0.539, h-index: 26)
Intl. J. of Computer Vision     Hybrid Journal   (Followers: 11, SJR: 5.633, h-index: 150)
Intl. J. of Computer-Supported Collaborative Learning     Hybrid Journal   (Followers: 16, SJR: 1.641, h-index: 39)
Intl. J. of Control, Automation and Systems     Hybrid Journal   (Followers: 12, SJR: 0.644, h-index: 33)
Intl. J. of Diabetes in Developing Countries     Open Access   (Followers: 7, SJR: 0.16, h-index: 16)
Intl. J. of Disclosure and Governance     Hybrid Journal   (Followers: 7, SJR: 0.156, h-index: 11)
Intl. J. of Dynamics and Control     Hybrid Journal   (Followers: 7)
Intl. J. of Early Childhood     Hybrid Journal   (Followers: 9, SJR: 0.407, h-index: 12)
Intl. J. of Earth Sciences     Hybrid Journal   (Followers: 31, SJR: 0.992, h-index: 70)
Intl. J. of Environmental Science and Technology     Hybrid Journal   (Followers: 6, SJR: 0.576, h-index: 46)
Intl. J. of Fracture     Hybrid Journal   (Followers: 11, SJR: 1.093, h-index: 68)
Intl. J. of Fuzzy Systems     Hybrid Journal  
Intl. J. of Game Theory     Hybrid Journal   (Followers: 5, SJR: 0.878, h-index: 32)
Intl. J. of Geo-Engineering     Open Access   (Followers: 1)
Intl. J. of Geosynthetics and Ground Engineering     Full-text available via subscription   (Followers: 3)
Intl. J. of Group Tensions     Hybrid Journal   (Followers: 1)
Intl. J. of Health Care Finance and Economics     Hybrid Journal   (Followers: 9, SJR: 0.446, h-index: 21)
Intl. J. of Hematology     Hybrid Journal   (Followers: 5, SJR: 0.779, h-index: 60)
Intl. J. of Hindu Studies     Hybrid Journal   (Followers: 11, SJR: 0.166, h-index: 5)
Intl. J. of Historical Archaeology     Hybrid Journal   (Followers: 46, SJR: 0.522, h-index: 19)
Intl. J. of Information Security     Hybrid Journal   (Followers: 32, SJR: 0.652, h-index: 27)
Intl. J. of Intelligent Transportation Systems Research     Hybrid Journal   (Followers: 9, SJR: 0.422, h-index: 6)
Intl. J. of Legal Medicine     Hybrid Journal   (Followers: 5, SJR: 1.372, h-index: 64)
Intl. J. of Machine Learning and Cybernetics     Hybrid Journal   (Followers: 8, SJR: 0.774, h-index: 20)
Intl. J. of Material Forming     Hybrid Journal   (Followers: 1, SJR: 0.504, h-index: 17)
Intl. J. of Mechanical and Materials Engineering     Open Access   (Followers: 4, SJR: 0.211, h-index: 13)
Intl. J. of Mechanics and Materials in Design     Hybrid Journal   (Followers: 5, SJR: 0.835, h-index: 15)
Intl. J. of Mental Health and Addiction     Hybrid Journal   (Followers: 16, SJR: 0.473, h-index: 22)
Intl. J. of Minerals, Metallurgy, and Materials     Hybrid Journal   (Followers: 10, SJR: 0.503, h-index: 21)
Intl. J. of Multimedia Information Retrieval     Partially Free   (Followers: 13)
Intl. J. of Occupational Medicine and Environmental Health     Hybrid Journal   (Followers: 19, SJR: 0.306, h-index: 33)
Intl. J. of Parallel Programming     Hybrid Journal   (Followers: 6, SJR: 0.255, h-index: 26)
Intl. J. of Peptide Research and Therapeutics     Partially Free   (Followers: 10, SJR: 0.329, h-index: 26)
Intl. J. of Plastics Technology     Hybrid Journal   (Followers: 1, SJR: 0.156, h-index: 4)
Intl. J. of Politics, Culture, and Society     Hybrid Journal   (Followers: 12, SJR: 0.198, h-index: 17)
Intl. J. of Precision Engineering and Manufacturing     Hybrid Journal   (Followers: 8, SJR: 0.659, h-index: 25)
Intl. J. of Precision Engineering and Manufacturing-Green Technology     Hybrid Journal   (SJR: 1.316, h-index: 7)
Intl. J. of Primatology     Hybrid Journal   (Followers: 6, SJR: 1.078, h-index: 59)
Intl. J. of Public Health     Hybrid Journal   (Followers: 19, SJR: 1.21, h-index: 41)
Intl. J. of Rehabilitation and Health     Hybrid Journal   (Followers: 17)
Intl. J. of Salt Lake Research     Hybrid Journal   (Followers: 2)
Intl. J. of Science and Mathematics Education     Hybrid Journal   (Followers: 22, SJR: 0.851, h-index: 20)
Intl. J. of Self-Propagating High-Temperature Synthesis     Hybrid Journal   (Followers: 2, SJR: 0.304, h-index: 5)
Intl. J. of Sexuality and Gender Studies     Hybrid Journal   (Followers: 23)
Intl. J. of Social Robotics     Hybrid Journal   (Followers: 3, SJR: 1.198, h-index: 22)
Intl. J. of Speech Technology     Hybrid Journal   (Followers: 8, SJR: 0.295, h-index: 19)
Intl. J. of Steel Structures     Hybrid Journal   (Followers: 2, SJR: 0.557, h-index: 8)
Intl. J. of Stomatology & Occlusion Medicine     Hybrid Journal  
Intl. J. of Systems Assurance Engineering and Management     Hybrid Journal   (SJR: 0.291, h-index: 10)
Intl. J. of Technology and Design Education     Hybrid Journal   (Followers: 12, SJR: 0.573, h-index: 24)
Intl. J. of the Classical Tradition     Hybrid Journal   (Followers: 7, SJR: 0.111, h-index: 3)
Intl. J. of Theoretical Physics     Hybrid Journal   (Followers: 17, SJR: 0.399, h-index: 44)
Intl. J. of Thermophysics     Hybrid Journal   (Followers: 3, SJR: 0.431, h-index: 50)
Intl. J. of Wireless Information Networks     Hybrid Journal   (Followers: 5, SJR: 0.229, h-index: 22)
Intl. J. on Digital Libraries     Hybrid Journal   (Followers: 578, SJR: 0.375, h-index: 28)
Intl. J. on Document Analysis and Recognition (IJDAR)     Hybrid Journal   (Followers: 2, SJR: 0.546, h-index: 38)
Intl. J. on Interactive Design and Manufacturing (IJIDeM)     Hybrid Journal   (Followers: 3, SJR: 0.299, h-index: 12)
Intl. J. on Software Tools for Technology Transfer (STTT)     Hybrid Journal   (Followers: 5, SJR: 0.806, h-index: 41)
Intl. Ophthalmology     Hybrid Journal   (Followers: 4, SJR: 0.526, h-index: 33)
Intl. Orthopaedics     Hybrid Journal   (Followers: 15, SJR: 1.508, h-index: 59)
Intl. Politics     Hybrid Journal   (Followers: 29, SJR: 0.378, h-index: 22)
Intl. Politics Reviews     Hybrid Journal   (Followers: 4)
Intl. Review of Economics     Hybrid Journal   (Followers: 5, SJR: 0.165, h-index: 8)
Intl. Review of Education     Hybrid Journal   (Followers: 10, SJR: 0.369, h-index: 22)
Intl. Review on Public and Nonprofit Marketing     Hybrid Journal   (Followers: 2, SJR: 0.216, h-index: 6)
Intl. Sports Law J.     Hybrid Journal   (Followers: 3, SJR: 0.16, h-index: 1)
Intl. Tax and Public Finance     Hybrid Journal   (Followers: 8, SJR: 0.799, h-index: 37)
Intl. Urogynecology J.     Hybrid Journal   (Followers: 5, SJR: 0.955, h-index: 72)
Intl. Urology and Nephrology     Hybrid Journal   (Followers: 5, SJR: 0.506, h-index: 38)
Inventiones mathematicae     Hybrid Journal   (Followers: 1, SJR: 5.874, h-index: 75)
Invertebrate Neuroscience     Hybrid Journal   (Followers: 3, SJR: 0.566, h-index: 28)
Investigational New Drugs     Hybrid Journal   (Followers: 10, SJR: 1.376, h-index: 68)
Ionics     Hybrid Journal   (Followers: 2, SJR: 0.486, h-index: 36)
Iranian Polymer J.     Hybrid Journal   (Followers: 4, SJR: 0.517, h-index: 28)
Irish J. of Medical Science     Hybrid Journal   (Followers: 1, SJR: 0.298, h-index: 23)
Irrigation and Drainage Systems     Hybrid Journal   (Followers: 3)
Irrigation Science     Hybrid Journal   (Followers: 4, SJR: 1.193, h-index: 46)
Israel J. of Mathematics     Hybrid Journal   (Followers: 1, SJR: 1.649, h-index: 40)
Italian Economic J.     Hybrid Journal   (Followers: 27)
Izvestiya Atmospheric and Oceanic Physics     Hybrid Journal   (Followers: 3, SJR: 0.279, h-index: 17)
Izvestiya, Physics of the Solid Earth     Hybrid Journal   (Followers: 2, SJR: 0.394, h-index: 13)
J. Africain d'Hépato-Gastroentérologie     Hybrid Journal   (Followers: 2, SJR: 0.142, h-index: 3)
J. africain du cancer / African J. of Cancer     Hybrid Journal   (Followers: 2, SJR: 0.188, h-index: 4)
J. d'Analyse Mathématique     Hybrid Journal   (Followers: 4, SJR: 1.973, h-index: 36)
J. for General Philosophy of Science     Hybrid Journal   (Followers: 7, SJR: 0.207, h-index: 10)
J. for Labour Market Research     Hybrid Journal   (Followers: 8)
J. fur Asthetische Chirurgie     Hybrid Journal   (SJR: 0.117, h-index: 4)
J. für Betriebswirtschaft     Hybrid Journal   (Followers: 2, SJR: 0.195, h-index: 9)
J. für Mathematik-Didaktik     Hybrid Journal   (Followers: 1, SJR: 0.226, h-index: 7)
J. für Rechtspolitik     Hybrid Journal  
J. für Verbraucherschutz und Lebensmittelsicherheit     Hybrid Journal   (SJR: 0.221, h-index: 17)
J. of Abnormal Child Psychology     Hybrid Journal   (Followers: 8, SJR: 2.03, h-index: 107)
J. of Academic Ethics     Hybrid Journal   (Followers: 4, SJR: 0.395, h-index: 10)
J. of Acupuncture and Tuina Science     Hybrid Journal   (Followers: 3, SJR: 0.216, h-index: 6)
J. of Adult Development     Hybrid Journal   (Followers: 7, SJR: 0.463, h-index: 30)
J. of Advancement in Medicine     Hybrid Journal  
J. of African American Studies     Hybrid Journal   (Followers: 8, SJR: 0.155, h-index: 8)
J. of Aging and Identity     Hybrid Journal   (Followers: 7)
J. of Agricultural and Environmental Ethics     Hybrid Journal   (Followers: 8, SJR: 0.508, h-index: 32)
J. of Agricultural, Biological & Environmental Statistics     Hybrid Journal   (Followers: 10, SJR: 0.571, h-index: 39)
J. of Algebraic Combinatorics     Hybrid Journal   (Followers: 2, SJR: 1.436, h-index: 27)
J. of Ambient Intelligence and Humanized Computing     Hybrid Journal   (SJR: 0.456, h-index: 11)
J. of Analytical Chemistry     Hybrid Journal   (Followers: 20, SJR: 0.268, h-index: 23)
J. of Analytical Science & Technology     Open Access   (Followers: 5)
J. of Anesthesia     Hybrid Journal   (Followers: 11, SJR: 0.513, h-index: 30)
J. of Applied and Industrial Mathematics     Hybrid Journal   (SJR: 0.176, h-index: 8)
J. of Applied Electrochemistry     Hybrid Journal   (Followers: 12, SJR: 0.676, h-index: 86)
J. of Applied Genetics     Partially Free   (Followers: 1, SJR: 0.621, h-index: 38)
J. of Applied Mathematics and Computing     Hybrid Journal   (SJR: 0.483, h-index: 24)
J. of Applied Mechanics and Technical Physics     Hybrid Journal   (Followers: 6, SJR: 0.199, h-index: 13)
J. of Applied Phycology     Hybrid Journal   (Followers: 10, SJR: 0.852, h-index: 73)
J. of Applied Spectroscopy     Hybrid Journal   (Followers: 9, SJR: 0.18, h-index: 15)
J. of Archaeological Method and Theory     Hybrid Journal   (Followers: 61, SJR: 1.464, h-index: 34)
J. of Archaeological Research     Hybrid Journal   (Followers: 52, SJR: 1.681, h-index: 36)
J. of Arid Land     Hybrid Journal   (Followers: 1, SJR: 0.56, h-index: 9)
J. of Artificial Organs     Hybrid Journal   (SJR: 0.66, h-index: 29)
J. of Asset Management     Partially Free   (Followers: 2, SJR: 0.181, h-index: 6)
J. of Assisted Reproduction and Genetics     Hybrid Journal   (Followers: 4, SJR: 0.858, h-index: 57)
J. of Astrophysics and Astronomy     Open Access   (Followers: 40, SJR: 0.226, h-index: 19)
J. of Atmospheric Chemistry     Hybrid Journal   (Followers: 20, SJR: 0.599, h-index: 59)
J. of Autism and Developmental Disorders     Hybrid Journal   (Followers: 40, SJR: 1.877, h-index: 123)
J. of Automated Reasoning     Hybrid Journal   (SJR: 1.63, h-index: 43)
J. of Banking Regulation     Hybrid Journal   (Followers: 23, SJR: 0.16, h-index: 7)
J. of Behavioral Education     Hybrid Journal   (Followers: 4, SJR: 0.763, h-index: 28)
J. of Behavioral Health Services & Research     Hybrid Journal   (Followers: 13, SJR: 0.555, h-index: 41)
J. of Behavioral Medicine     Hybrid Journal   (Followers: 3, SJR: 1.069, h-index: 73)
J. of Bio- and Tribo-Corrosion J. of Bio- and Tribo-Corrosion     Hybrid Journal  
J. of Bioeconomics     Hybrid Journal   (Followers: 1, SJR: 0.391, h-index: 18)
J. of Bioenergetics and Biomembranes     Hybrid Journal   (Followers: 1, SJR: 1.092, h-index: 83)
J. of Bioethical Inquiry     Hybrid Journal   (Followers: 3, SJR: 0.396, h-index: 13)
J. of Biological Physics     Hybrid Journal   (SJR: 0.481, h-index: 33)
J. of Biomedical Science     Open Access   (Followers: 4, SJR: 1.28, h-index: 59)
J. of Biomolecular NMR     Hybrid Journal   (Followers: 7, SJR: 2.043, h-index: 89)
J. of Biorheology     Hybrid Journal   (SJR: 0.122, h-index: 7)
J. of Biosciences     Open Access   (SJR: 0.841, h-index: 54)
J. of Bone and Mineral Metabolism     Hybrid Journal   (Followers: 3, SJR: 0.775, h-index: 56)
J. of Brand Management     Hybrid Journal   (Followers: 15, SJR: 0.535, h-index: 22)
J. of Business and Psychology     Hybrid Journal   (Followers: 7, SJR: 1.385, h-index: 46)
J. of Business Economics     Hybrid Journal   (Followers: 6)
J. of Business Ethics     Hybrid Journal   (Followers: 35, SJR: 1.358, h-index: 98)
J. of Cachexia, Sarcopenia and Muscle     Open Access   (Followers: 2, SJR: 1.955, h-index: 26)
J. of Cancer Education     Hybrid Journal   (Followers: 3, SJR: 0.525, h-index: 33)
J. of Cancer Research and Clinical Oncology     Hybrid Journal   (Followers: 16, SJR: 1.19, h-index: 76)
J. of Cancer Survivorship     Hybrid Journal   (Followers: 2, SJR: 2, h-index: 34)
J. of Cardiovascular Translational Research     Hybrid Journal   (Followers: 1, SJR: 1.567, h-index: 32)
J. of Cell Communication and Signaling     Hybrid Journal   (SJR: 1.195, h-index: 27)
J. of Central South University     Hybrid Journal   (Followers: 1, SJR: 0.335, h-index: 20)
J. of Chemical Biology     Hybrid Journal   (Followers: 1, SJR: 0.685, h-index: 14)
J. of Chemical Crystallography     Hybrid Journal   (Followers: 2, SJR: 0.25, h-index: 28)
J. of Chemical Ecology     Hybrid Journal   (Followers: 6, SJR: 1.559, h-index: 88)
J. of Chemical Sciences     Partially Free   (Followers: 17, SJR: 0.322, h-index: 37)
J. of Child and Adolescent Group Therapy     Hybrid Journal   (Followers: 2)
J. of Child and Family Studies     Hybrid Journal   (Followers: 17, SJR: 0.549, h-index: 50)
J. of Children's Orthopaedics     Hybrid Journal   (Followers: 9, SJR: 0.584, h-index: 18)
J. of Chinese Political Science     Hybrid Journal   (Followers: 7, SJR: 0.515, h-index: 9)
J. of Chinese Sociology     Open Access   (Followers: 2)
J. of Civil Structural Health Monitoring     Hybrid Journal   (Followers: 4, SJR: 0.296, h-index: 7)
J. of Classification     Hybrid Journal   (Followers: 7, SJR: 0.968, h-index: 29)
J. of Clinical Geropsychology     Hybrid Journal   (Followers: 1)
J. of Clinical Immunology     Hybrid Journal   (Followers: 13, SJR: 1.332, h-index: 75)
J. of Clinical Monitoring and Computing     Hybrid Journal   (Followers: 1, SJR: 0.661, h-index: 37)
J. of Clinical Psychology in Medical Settings     Hybrid Journal   (Followers: 12, SJR: 0.46, h-index: 34)
J. of Cluster Science     Hybrid Journal   (SJR: 0.416, h-index: 31)
J. of Coal Science and Engineering (China)     Hybrid Journal   (SJR: 0.188, h-index: 8)
J. of Coastal Conservation     Hybrid Journal   (Followers: 7, SJR: 0.474, h-index: 25)
J. of Coatings Technology and Research     Hybrid Journal   (Followers: 5, SJR: 0.425, h-index: 25)

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Journal Cover Neurophysiology
  [SJR: 0.168]   [H-I: 9]   [1 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1573-9007 - ISSN (Online) 0090-2977
   Published by Springer-Verlag Homepage  [2341 journals]
  • Mechanisms Responsible for the High Sensitivity of Neural Cells to Vitamin
           B 1 Deficiency
    • Authors: Yu. M. Parkhomenko; A. S. Pavlova; O. A. Mezhenskaya
      Abstract: The available information on the mechanisms of involvement of vitamin B1 (thiamine) in vital processes in neural cells is analyzed. It is concluded that, together with the coenzymatic functions performed by this vitamin, the latter realizes “noncoenzymatic” functions. These functions play significant roles in cellular processes in various cells, and this is an indisputable fact. Some features of the structural/functional organization of neurons are responsible for the importance of thiamine-dependent processes for the maintenance of the functional activity of these cells. The accumulated data on the release of thiamine from neurons in the course of their excitation, as well as on the high dynamics of B1 metabolism in nerve cells related to rapid changes between states of excitation and inhibition, allow researchers to formulate an idea on the existence of a rapidly exchanged pool of thiamine ant its biologically active derivatives (“mobile thiamine pool”) in such cells. It is hypothesized that circulation of this pool between the main part of the intracellular space and presynaptic compartments of the synaptic structures is associated with changes in the membrane potential of nerve cells and modifications of cellular metabolism. This is confirmed by the data on coupling of the regulation of the mitochondrial multienzyme pyruvate dehydrogenase complex with the functioning of the excitable membranes. It is suggested that the interaction of thiamine with cytoskeletal proteins plays an important role in vitally important nonenzymatic processes realized by this vitamin in neural cells. The possible role of thiamine deficiency in the development of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and Wernicke’s encephalopathy, is discussed.
      PubDate: 2017-03-31
      DOI: 10.1007/s11062-017-9620-3
       
  • Ethical Responsibilities of the Authors
    • PubDate: 2017-03-30
      DOI: 10.1007/s11062-017-9614-1
       
  • Features of the EEG Spectral Composition in Patients with
           Cervicocranialgias and Dorsalgias of Different Origin
    • Authors: I. A. Nazarchuk; V. I. Sukhorukov; L. P. Zabrodina; S. V. Fedoseyev
      Abstract: We examined the spectral composition of ongoing EEG activity in 77 patients suffering from intense pain in the neck and/or back (cervicocranialgia and/or dorsalgia) caused by neurological vertebral disorders of reflex origin (group VDRO, n = 43), multiple sclerosis (group MS, n = 17), and consequences of earlier neuroinfections (group NIC, n = 17). Visual analysis of EEG records of these patients showed the existence of disorganized EEG patterns more intensely manifested in the latter two groups. Spectral EEG analysis demonstrated that the averaged spectral powers (SPs) of β1 and β2 oscillations in patients of group MS were, in almost all EEG leads, significantly greater than those in subjects of groups VDRO and NIC, while the SP of θ activity in most cortical loci (except frontal ones) was significantly lower. The SP of the β1 and β2 subrhythms demonstrated significant negative correlations with the frequency of pain attacks in the VDRO group. At the same time, the power of this subrhythm in the MS group showed close positive correlations with the pain intensity, while these indices in the group NIC correlated with the frequency of pain attacks. The increased power of high-frequency components of ongoing EEG can be considered an EEG correlate of dorsalgials and cervicocranialgias in MS patients.
      PubDate: 2017-03-30
      DOI: 10.1007/s11062-017-9617-y
       
  • Gender Specificity of Genistein Treatment in Penicillin-Induced
           Epileptiform Activity in Rats
    • Authors: A. Bahadir; S. Demir; H. Orallar; E. Beyazcicek; A. Cetinkaya; S. Ankarali; H. Ankarali
      Abstract: We investigated gender-dependent differences of genistein (isoflavone phytoestrogen) treatment in a penicillin-induced experimental epilepsy rat model. Twenty-eight adult Wistar Albino rats (14 females and 14 males) were devided into four groups, control and genistein-treatmed males and females. Genistein (100 μg/kg, i.p) or saline was given during 15 days before the electrocorticography (ECoG) recordings. The epileptiform activity was induced by penicillin G potassium salt (500 IU) injections into the left somatomotor cortex. Significant differences among the groups were found in the latency to onset of epileptiform activity. This value in the female control group was significantly longer than the latencies in the male control, male genistein, and female genistein groups (respectively, P = 0.002, 0.015, and 0.032). There were no significant differences regarding the spike/wave frequencies and amplitudes in epileptiform activity between female/male genistein and control groups within all observation intervals (P > 0.05). Thus, genistein exerts a proconvulsant effect in the penicillin-induced epilepsy model, and the effect demonstrates the clear gender specificity related to the specificity of hormonal backgrounds in males and females.
      PubDate: 2017-03-30
      DOI: 10.1007/s11062-017-9619-9
       
  • Parameters of the P300 Potential in Mild Neurocognitive Disorders of
           Different Etiologies
    • Authors: O. V. Levada; N. V. Cherednichenko; S. V. Gorbachev
      Abstract: The latency and amplitude of the auditory evoked Р300 potential were measured in 25 elderly and old persons without any cognitive impairments (control group), 32 patients with mild neurocognitive disorder induced by Alzheimer’s disease (AD MNCD), and 33 patients with analogous impairment of subcortical vascular genesis (SCV MNCD). The examined groups did not differ from each other significantly in age, sex, and educational level. It was found that the mean latency of the Р300 wave in patients suffering from SCV MNCD (507.9 ± 203.6 msec) was significantly longer as compared with the analogous parameter in two other groups. The value of such increment allows one to differentiate SCV MNCD from the groups without cognitive impairment (326.9 ± 103.6 msec, Р = 0.00005) and AD MNCD (378.9 ± 99.9 msec Р = 0.0007). The increased P300 latency is related to the severity and clinical specificity of SCV MNCD and reflects a crucial influence of the microvascular cerebral frontosubcortical injury on the generation of this neurophysiological phenomenon. We conclude that the level of increase in the latency of wave Р300 can be used as a valid neurophysiological marker for differential diagnostics of MNCDs of the main etiological types.
      PubDate: 2017-03-30
      DOI: 10.1007/s11062-017-9618-x
       
  • Morphofunctional Modifications of Neurocytes of the Rat Hippocampal CA3
           Area after Experimental Thermal Trauma
    • Authors: S. O. Lytvynyuk; K. S. Volkov; Z. M. Nebesna
      Abstract: In experiments on mature male Wistar rats, the dynamics of morphological modifications of neurocytes of the hippocampal CA3 area after a severe thermal trauma were examined. The pattern and degree of morphofunctional changes in the nerve cells depended significantly on the time interval after thermal trauma; their intensity correlated with the stages of burn disease. At stages of acute shock and early toxemia (days 1 to 7), mostly effects that could be interpreted as adaptive/compensatory reactions were observed, although initial signs of destructive changes were also obvious. At stages of late toxemia and septicotoxemia (days 14 to 21), deep irreversible destructive modifications in a considerable part of neurocytes of the hippocampal CA3 area became appreciable. The proportions of neurocytes belonging to different morphological types and values of the nucleo-cytoplasmic ratio (NCR) in such cells changed significantly. After an experimental burn, the total density of neurocytes gradually decreased, while portions of sharply hypo- and hyperchromic cells, in which NCRs underwent maximum modifications, increased. Electron microscopy of CA3 nerve cell demonstrated the development of destructive changes in the nuclei and cytoplasmic structures (degranulation of the endoplasmic reticulum, decrease in the number of ribosomes and polysomes, hypertrophy of the mitochondria with clarification of their matrix and destruction of mitochondrial cristae, and increase in the number of lysosomes). Therefore, severe thermal trauma induces significant morphofunctional modifications of neurocytes in the hippocampal CA3 area.
      PubDate: 2017-03-30
      DOI: 10.1007/s11062-017-9616-z
       
  • To the 130th Anniversary of the Birth of Academician Daniil Vorontsov.
           Vorontsov’s Scientific Concepts: Past, Present, and Future of
           Neuroscience in Ukraine
    • Authors: I. S. Magura; N. A. Bogdanova
      PubDate: 2017-03-30
      DOI: 10.1007/s11062-017-9621-2
       
  • Changes in the Sphingolipid Content in Tissues and Behavioral
           Modifications of Rats Subjected to Neurogenic Stress: Role of
           Sphingomyelinases
    • Authors: N. A. Babenko; V. M. Shevereva; V. V. Gar’kavenko
      Abstract: We studied changes in the level of ceramide and sphingomyelin (SM) in the neocortex and peripheral tissues of rats after chronic (7-day-long) neurogenic stress (sessions of nociceptive stimulation in a chamber with an electrified floor) and after such stress induced against the background of course (14 days) injections of the tricyclic antidepressant imipramine. The latter agent, as is known, is a functional inhibitor of acid sphingomyelinase (aSMase). Introductions of imipramine considerably prevented manifestations of a state similar to depression (depression-like state, DLS). Suppression of motor/research activity was weakened, manifestations of emotional phenomena (acts of defecation and urination) decreased, and the latency of leaving the center of the open field became shorter. Imipramine injected into stressed animals decreased the ceramide/SM ratio and the level of ceramide in the neocortex, liver, and blood serum; the concentration of SM in the blood serum increased somewhat, as compared with the corresponding indices in rats subjected to isolated action of stress. Such changes in the levels of sphingolipids were also manifested after direct action of imipramine on isolated slices of the neocortex of stressed rats. The obtained results are indicative of the important role of the level of activity of aSMase in alterations of the ceramide/SM ratio in the neocortex of rats and in changes in the corresponding modifications of their behavior. Levels of sphingolipids in the blood serum can be the important index of the efficacy of the action of antidepressants under conditions of chronic stress and after the development of the DLS.
      PubDate: 2017-03-30
      DOI: 10.1007/s11062-017-9615-0
       
  • Ethical Responsibilities of the Authors
    • Pages: 323 - 323
      PubDate: 2016-10-01
      DOI: 10.1007/s11062-017-9604-3
      Issue No: Vol. 48, No. 5 (2016)
       
  • Temperature Deactivation of the Depolarizing TRP Current as a Mechanism of
           Hypothermia-Related Inhibition of Neuronal Activity: a Model Study
    • Authors: S. M. Korogod; L. E. Demianenko
      Pages: 324 - 331
      Abstract: Therapeutic neuroprotective hypothermia is becoming increasingly used to suppress abnormally high neuronal activity in the brain occurring under conditions of ischemic and traumatic injuries, refractory epilepsy, etc. This makes especially topical examination of the factors determining the temperature dependence of the intensity of neuronal excitation. In this respect, of interest are thermosensitive TRP-type channels conducting depolarization currents and found in central neurons. We explored such channels and their functional role using computer modeling. These channels were present in the membrane of a simulated dentate gyrus granule cell of the hippocampus. The chanels can be in two states, open and closed, and the probabilities of these states are temperature-dependent. The model adequately reproduced the key feature of the prototype, namely voltage-dependent activation of TRP channels shifted toward depolarization with a decrease in the temperature. At identical potentials, the level of such activation was reduced, i.e., a deactivation phenomenon was observed. The decrease of temperature from 37°C (normothermia) to 20°C (focal deep hypothermia) was accompanied by a significant decrease in the frequency of action potentials generated by the simulated neuron in response to tonic synaptic excitation of the same intensity. This hypothermic inhibition was most pronounced within the temperature range where temperature-dependent deactivation of TRP channels developed. This effect was much less manifested in the case where TRP channels were “turned off,” which mimicked their genetic knockout. Such results obtained on a rather simplified model reveal new aspects of the neuroprotective effect of hypothermia, which deserves further in-depth studies.
      PubDate: 2016-10-01
      DOI: 10.1007/s11062-017-9605-2
      Issue No: Vol. 48, No. 5 (2016)
       
  • Effect of Tubocurarine on Large-Conductance Cationic Channels in the Inner
           Nuclear Membrane of Purkinje Neurons of the Rat Cerebellum
    • Authors: O. V. Lunko; I. V. Grushkovska; O. O. Lun’ko; S. M. Marchenko
      Pages: 332 - 335
      Abstract: Large-conductance cationic channels (LCCs) are present in the nuclear membranes of Purkinje neurons. Channels of this type are characterized by their selectivity with respect to monovalent cations, high unitary conductance, slow kinetics, and voltage dependence. The structural peculiarities, amino acid sequence in the molecules, and physiological role of these channels remain unknown. It is obvious that elucidation of functions of LCCs in the nuclear membranes depends on identification of a specific blocker of these channels. We carried out experiments using the patch-clamp technique and found a specific blocker of LCC channels. A well-known alkaloid, tubocurarine, was found to completely block the conductivity of LCC channels after application in concentrations of 1.0 mM or greater under conditions where the charge on the nuclear membrane is negative. At present, this compound is the only effective blocker of channels of the above-mentioned type.
      PubDate: 2016-10-01
      DOI: 10.1007/s11062-017-9606-1
      Issue No: Vol. 48, No. 5 (2016)
       
  • Dependence of Vitamin B 1 Metabolism and the State of Astroglia in the Rat
           Brain on the Supply with this Vitamin
    • Authors: A. S. Pavlova; S. P. Stepanenko; L. I. Chekhovskaya; A. A. Tikhomirov; Yu. M. Parkhomenko
      Pages: 336 - 345
      Abstract: Vitamin В1 deficiency was modeled in rats; their daily diet during 6 weeks contained about 20% of the necessary amount of thiamine. Under these conditions, the total content of vitamin В1 (thiamine) in the liver was, on average, 18.3% of the control, while the content of thiamine diphosphate (ТDP) in the blood and cerebral tissues was 40%. General indices of the redox balance (levels of reactive oxygen species, ROSs, and of free SH groups) were also smaller. The activity of thiamine pyrophosphokinase (TPK) in the brain homogenate of animals with thiamine deficiency (TD) was 35% higher than that in the control. In three cerebral structures, the cortex, cerebellum, and hippocampus, we measured the contents of proteins involved in thiamine metabolism, namely thiamine transporter (ТHTR) and TPK. In TD, directions of alterations of these indices for the above-mentioned proteins were opposite; the TPK content in all cerebral structures increased, while the THTR content in the cerebellum and hippocampus decreased. After single injections of 2.0 mg/kg thiamine into animals with TD 24 h before the completion of the experiment, the content of TPK in all cerebral structures increased. As to ТHТR, such effect was observed only in the cortex, while the reactions to thiamine injections in the cerebellum and hippocampus were not clearly manifested. We also estimated the content of glial fibrillary acidic protein (GFAP), an astrocyte marker, in all examined cerebral structures. In TD, this index was stably lower in all structures but returned to nearly control levels after single thiamine injection. Possible relations between alterations in the content of key proteins involved in thiamine metabolism and the supply of the organism with this vitamin are discussed.
      PubDate: 2016-10-01
      DOI: 10.1007/s11062-017-9607-0
      Issue No: Vol. 48, No. 5 (2016)
       
  • Effects of Chronic Neurogenic Stress on Behavior of Rats and Contents of
           Sphingolipids in Their Brain and Peripheral Tissues
    • Authors: N. A. Babenko; V. M. Shevereva; V. V. Gar’kavenko
      Pages: 346 - 353
      Abstract: We studied the contents of ceramide and sphingomyelin (SM) in the hippocampus, neocortex, and peripheral tissues of rats and the behavior characteristics of these animals in the open field at different times after the induction of chronic neurogenic stress. The experiments were carried out on young Wistar rats weighing 180–220 g, with a mean level of behavioral mobility. Within the poststress period, animals demonstrated significant suppression of manifestations of motor and orientational/research activities, and intensification of autonomic manifestations of fear and anxiety (with a delay of leaving the field center). One day after termination of stressing, the content of ceramide in the hippocampus increased against the background of a drop in the SM level, but this did not occur in the neocortex, liver, and blood serum. The contents of phosphatidylcholine and phosphatidylethanolamine in the brains of animals exposed to stress did not change. Eight days after stressing, the level of ceramide in the brain structures and blood serum was significantly higher than in the control. These data suggest that the action of chronic neurogenic stress leads to activation of metabolism of sphingolipids and intensification of production of ceramide in the brain and blood serum. Accumulation of ceramide in the serum within a remote period after termination of the action of stress can serve as a marker of the stable development of a state of emotional tension accompanied by typical signs of depression-like behavior.
      PubDate: 2016-10-01
      DOI: 10.1007/s11062-017-9608-z
      Issue No: Vol. 48, No. 5 (2016)
       
  • Expression of Vascular Endothelial Growth Factor in the Rat Cerebral
           Cortex after Blood Supply Disturbances and Immunocorrection of Their
           Consequences
    • Authors: L. M. Yaremenko; O. O. Grabovyi; O. M. Grabovyi
      Pages: 354 - 359
      Abstract: In rats with acute circulatory disturbances in one of the brain hemispheres resulting from ligation of the a. carotis or microembolization of the cortical blood vessels after intra-arterial injection of suspension of adipocytes, the expression of vascular endothelial growth factor (VEGF) in the cortex of this hemisphere was temporarily decreased. This event can be considered a pathogenetic factor affecting the regenerative processes after ischemization of the cortex. Weakening of VEGF expression was probably a factor providing prolongation of the ischemia-induced degenerative phenomena. The use of an immunomodulator, Immunofan, decreased the intensity of drop in the VEGF expression after transitory cortical ischemia, and this led to more favorable conditions for postischemic recovery, decreased the intensity of neurodegenerative processes, and led to an increase in the number of gliocytes.
      PubDate: 2016-10-01
      DOI: 10.1007/s11062-017-9609-y
      Issue No: Vol. 48, No. 5 (2016)
       
  • Prenatal Stress+Morphine and Postnatal Re-exposure to Stress Alter
           Pentylenetetrazol-Induced Epileptic Manifestations in Rats
    • Authors: E. Nakhjiri; E. Saboory; Sh. Roshan-Milani; Y. Rasmi; H. Sayyadi
      Pages: 360 - 366
      Abstract: We studied effects of restraint-induced stress and morphine co-administration within the prenatal period and of re-exposure to stress at the end of infancy on the body mass and pentylenetetrazol-induced epileptic manifestations in rats. Pregnant rats were divided into six groups (control, restraint stressed, saline, morphine, stress+saline, and stress+morphine). In the stressed groups, pregnant rats were subjected to restraint stressing twice per day for three consecutive days (starting on pregnancy day 15). Rats in saline and morphine groups received saline and morphine subcutaneously on the same days. In the morphine/saline+stressed groups, rats were exposed to stress and received morphine/saline simultaneously. Control rats were used intact. The pups were weighed at postnatal days (PD) 1, 15, and 22. On P22, half of the pups were re-exposed to stress; then, pentylenetetrazol (PTZ)-induced seizures were recorded. The offspring body mass was significantly smaller in stressed, morphine, and stressed+morphine groups compared to the control. The time to onset of the first tonic-clonic seizure was shorter, while the duration and number of tonic-clonic attacks were significantly greater in the stressed+morphine group compared to other groups. Re-exposure to stress decreased the number of clonic seizures. The number of leg-opening and tail rigidity episodes was smaller in female offspring compared to male ones. Co-administration of restraint stress and morphine within the prenatal period reduces the offspring body mass and increases the seizure vulnerability more severely compared to the respective individual effects In addition, prenatal stress exerts stronger effects on the neural development and epileptic behaviors of the offspring than postnatal stress.
      PubDate: 2016-10-01
      DOI: 10.1007/s11062-017-9610-5
      Issue No: Vol. 48, No. 5 (2016)
       
  • Penicillin-Induced Epileptiform ECoG Activity in Gerbils: Effects of
           Physical Exercise and a Diospyros kaki Extract
    • Authors: Y. Kayacan; A. Bahadir; A. Cetinkaya; H. Orallar; S. Cakir; E. Beyazcicek; A. C. Onal; A. Yildirim
      Pages: 367 - 374
      Abstract: Mongolian gerbils (28 males) were divided into four groups, control (C), treadmill-exercised (Ex), treated with the extract of Diospyros kaki (Dk), and exercised plus treated with the Dk extract (Ex+Dk). Animals of the respective groups were running-exercised for 30 min per day during 8 weeks, and the Dk extract (dose 20 mg/kg) was given by gavage during five days per week within the same period. After the treatment and exercise period, an epilepsy model was produced by penicillin G injection (500 IU) into the left somatomotor cortex, and the electrocorticogram (ECoG) was recorded during 120 min. The mean frequency of spike/wave complexes was significantly smaller in the Ex and Ex+Dk groups from the 65th min of the observation period and, in the Dk group, from the 75th min than the respective value in the C group (P < 0.01, P < 0.05, and P < 0.01, respectively). The differences in the amplitude values and latency to onset of the spike/wave events among all groups did not reach the significance level (P > 0.05). Thus, both the running exercise and Dk extract applications inhibit penicillin-induced epileptiform activity by altering the spike/wave frequency or severity of seizures observed in ECoG recordings. Further studies are needed to determine the effects of physical activity of different intensities and forms and to analyze the active compounds in the Dk extract.
      PubDate: 2016-10-01
      DOI: 10.1007/s11062-017-9611-4
      Issue No: Vol. 48, No. 5 (2016)
       
  • Mastication Patterns in Humans: Gender Differences
    • Authors: S. Khamnei; M. Zamanlu; S. K. Shakouri; S. S. Oskoee; Sh. SalariLak; Y. Houshyar; Y. Salekzamani
      Pages: 375 - 379
      Abstract: Nineteen young healthy subjects were offered a morsel of hard (walnut) and soft (cake) food, while surface EMG was recorded bilaterally from the masseter muscles. The duration of the entire sequence of chewing, chewing rate, number of chewing cycles, time/cycle ratio, and mean and maximum EMG amplitudes of the above muscles were compared in women and men (n = 12 and 7, respectively). The duration of the whole chewing sequence for the soft food and duration of a single chewing cycle for both food types were significantly longer in women (P = 0.000). The masticatory frequencies for both food types were significantly greater in men (soft food: 0.98 ± 0.18 and 1.79 ± 0.18 sec–1, hard food: 1.25 ± 0.29 and 2.03 ± 0.32 sec–1 in women and men, respectively; P = 0.000). The numbers of chewing cycles for both food types were statistically similar (P = 0.38 and P = 0.67). The mean and maximum EMG amplitude were found to be nearly similar in women and men, except that the mean amplitude of the right EMG at soft food chewing was significantly higher in men (P = 0.02). Thus, chewing in women occurs, in general, more slowly, while masseter muscle activities are rather similar. The food consistency exerts a mild overall influence on the gender differences of chewing.
      PubDate: 2016-10-01
      DOI: 10.1007/s11062-017-9612-3
      Issue No: Vol. 48, No. 5 (2016)
       
  • Animal Models of Autism Spectrum Disorders and Behavioral Techniques of
           their Examination
    • Authors: S. V. Hrabovska; Yu. T. Salyha
      Pages: 380 - 388
      Abstract: Autism spectrum disorders constitute a significant problem in modern neurology and in neuroscience in general. At present, the incidence of such disorders is increasing, reasons for their appearance remain practically unclear, and there are no sufficiently effective treatments of these pathologies. A few animal models of autistic disorders have been developed; these models reproduce one or a few key symptoms of autism (cognitive rigidity, violations of social interactions, and qualitative disorders of communication). The respective simulations are carried out using either techniques of genetic engineering (knockout rats and mice) or early (pre- or postnatal) influences of certain environmental factors. To investigate behavioral deviations in the model animals, behavioral testing methods are used. A part of them are “classic” (e.g., the open field test, Morris water maze, T-like maze, radial maze, and Skinner’s chamber), while others have been designed specifically for models of autism. This review describes and analyzes the main methodical approaches in modeling of autism spectrum disorders in animals, and behavioral methods used in the studies of these models.
      PubDate: 2016-10-01
      DOI: 10.1007/s11062-017-9613-2
      Issue No: Vol. 48, No. 5 (2016)
       
  • Ethical Responsibilities of the Authors
    • Pages: 219 - 219
      PubDate: 2016-08-01
      DOI: 10.1007/s11062-016-9591-9
      Issue No: Vol. 48, No. 4 (2016)
       
  • Relationship Between the Reaction Time and EEG Parameters During Judgments
           on the Correspondence of Delayed or Simultaneously Presented Images of Two
           Models
    • Authors: T. Ishikura
      Pages: 270 - 276
      Abstract: This study examined how judging whether the poses of two figures are the same in tasks with delayed and simultaneous image presentation affects the participants’ reaction times and electroencephalograms (EEGs). Eighteen university students performed a delayed task, in which an image of a doll was first presented for 3 sec followed by a second image of the doll, and a simultaneous task, in which images of two dolls were presented on the left and right sides of the monitor at the same time. The dolls were shown from the front and rear angles. The participants were instructed to judge whether the images were the same as accurately and quickly as possible, and the reaction times were recorded. EEG signals were recorded from Fp1, Fp2, F3, F4, C3, C4, P3, and P4. The reaction times in the delayed task were found to be shorter then those in the simultaneous task, and that these times for the 0° condition were shorter than for the 180° condition. The amplitudes of EEG responses at Fp1 and Fp2 were larger than those at other electrodes, and the responses in the right hemisphere during the 180° condition and the delayed task within the α1 frequency band were smaller than the responses at other electrodes. These results indicate that cerebral activity in the frontal region of the right hemisphere is associated with the judgment of correspondence or non-correspondence in spatial compatibility tasks.
      PubDate: 2016-08-01
      DOI: 10.1007/s11062-016-9599-1
      Issue No: Vol. 48, No. 4 (2016)
       
 
 
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