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Publisher: SciELO   (Total: 717 journals)

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Showing 1 - 200 of 717 Journals sorted alphabetically
ABCD. Arquivos Brasileiros de Cirurgia Digestiva     Open Access   (Followers: 2, SJR: 0.277, h-index: 5)
ACIMED     Open Access   (Followers: 1)
Acta Agronómica     Open Access   (Followers: 1, SJR: 0.11, h-index: 2)
Acta Amazonica     Open Access   (Followers: 4, SJR: 0.32, h-index: 18)
Acta Bioethica     Open Access   (Followers: 1, SJR: 0.131, h-index: 4)
Acta Botanica Brasilica     Open Access   (Followers: 2, SJR: 0.364, h-index: 23)
Acta botánica mexicana     Open Access   (Followers: 1, SJR: 0.251, h-index: 6)
Acta Cirurgica Brasileira     Open Access   (SJR: 0.319, h-index: 19)
Acta Limnologica Brasiliensia     Open Access   (Followers: 3, SJR: 0.29, h-index: 6)
Acta Literaria     Open Access   (Followers: 3, SJR: 0.1, h-index: 2)
Acta Medica Colombiana     Open Access   (Followers: 1)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Neurológica Colombiana     Open Access   (Followers: 1)
Acta Ortopédica Brasileira     Open Access   (Followers: 1, SJR: 0.288, h-index: 10)
Acta Paulista de Enfermagem     Open Access   (Followers: 2, SJR: 0.242, h-index: 15)
Acta Pediátrica Costarricense     Open Access   (Followers: 1)
Acta Scientiarum. Agronomy     Open Access   (Followers: 4, SJR: 0.961, h-index: 15)
Acta zoológica mexicana     Open Access  
Actualidades Biológicas     Open Access   (Followers: 1)
African Human Rights Law J.     Open Access   (Followers: 19)
African Natural History     Open Access   (Followers: 2, SJR: 0.106, h-index: 4)
Afro-Asia     Open Access  
Ágora - studies in psychoanalytic theory     Open Access   (Followers: 3, SJR: 0.101, h-index: 2)
Agricultura Tecnica     Open Access   (Followers: 5)
Agrociencia     Open Access   (Followers: 1, SJR: 0.213, h-index: 15)
Agrociencia Uruguay     Open Access  
Agronomía Mesoamericana     Open Access  
Aisthesis     Open Access   (Followers: 4, SJR: 0.1, h-index: 1)
Alea : Estudos Neolatinos     Open Access   (Followers: 2, SJR: 0.1, h-index: 3)
Alfa : Revista de Linguística     Open Access  
Alpha (Osorno)     Open Access   (SJR: 0.114, h-index: 3)
Ambiente & sociedade     Open Access   (Followers: 2, SJR: 0.142, h-index: 8)
Ambiente & Agua : An Interdisciplinary J. of Applied Science     Open Access   (Followers: 1, SJR: 0.221, h-index: 4)
Ambiente Construído     Open Access   (Followers: 1)
América Latina en la historia económica     Open Access   (Followers: 2, SJR: 0.148, h-index: 1)
Anais Brasileiros de Dermatologia     Open Access   (Followers: 3, SJR: 0.498, h-index: 23)
Anais da Academia Brasileira de Ciências     Open Access   (Followers: 2, SJR: 0.322, h-index: 42)
Anais do Museu Paulista : História e Cultura Material     Open Access   (Followers: 1)
Anales de Medicina Interna     Open Access   (Followers: 1)
Anales del Instituto de la Patagonia     Open Access   (Followers: 1)
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1, SJR: 0.196, h-index: 18)
Análise Psicológica     Open Access   (Followers: 1, SJR: 0.129, h-index: 3)
Análise Social     Open Access   (Followers: 1, SJR: 0.109, h-index: 8)
Andean geology     Open Access   (Followers: 13, SJR: 0.997, h-index: 25)
Annali dell'Istituto Superiore di Sanità     Open Access   (SJR: 0.318, h-index: 29)
Antipoda. Revista de Antropología y Arqueología     Open Access   (Followers: 5, SJR: 0.1, h-index: 0)
Anuario Colombiano de Historia Social y de la Cultura     Open Access   (SJR: 0.101, h-index: 1)
Anuario de Historia Regional y de las Fronteras     Open Access  
Apuntes : Revista de Estudios sobre Patrimonio Cultural - J. of Cultural Heritage Studies     Open Access   (Followers: 4)
Archivos de Medicina Veterinaria     Open Access   (Followers: 2, SJR: 0.199, h-index: 16)
Archivos de Neurociencias     Open Access   (Followers: 3, SJR: 0.1, h-index: 4)
Archivos de Pediatria del Uruguay     Open Access   (Followers: 3)
Archivos de Zootecnia     Open Access   (Followers: 1, SJR: 0.248, h-index: 9)
Archivos Españoles de Urología     Open Access   (SJR: 0.188, h-index: 19)
ARQ     Open Access   (Followers: 4, SJR: 0.1, h-index: 2)
Arquitectura y Urbanismo     Open Access   (Followers: 2)
Arquivo Brasileiro de Medicina Veterinária e Zootecnia     Open Access   (SJR: 0.307, h-index: 22)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 1, SJR: 0.334, h-index: 32)
Arquivos Brasileiros de Endocrinologia e Metabologia     Open Access  
Arquivos Brasileiros de Oftalmologia     Open Access   (SJR: 0.308, h-index: 19)
Arquivos de Gastroenterologia     Open Access   (Followers: 1, SJR: 0.424, h-index: 22)
Arquivos de Medicina     Open Access   (SJR: 0.1, h-index: 5)
Arquivos de Neuro-Psiquiatria     Open Access   (SJR: 0.374, h-index: 38)
Arquivos do Instituto Biológico     Open Access   (Followers: 1)
Arquivos Internacionais de Otorrinolaringologia     Open Access  
ARS     Open Access   (Followers: 2)
Atenea (Concepción)     Open Access   (SJR: 0.111, h-index: 3)
Atmósfera     Open Access   (Followers: 2, SJR: 0.377, h-index: 18)
Audiology - Communication Research     Open Access   (Followers: 8)
Avaliação : Revista da Avaliação da Educação Superior (Campinas)     Open Access  
Avances en Odontoestomatologia     Open Access   (Followers: 1, SJR: 0.109, h-index: 4)
Avances en Periodoncia e Implantología Oral     Open Access   (Followers: 1)
Bakhtiniana : Revista de Estudos do Discurso     Open Access  
BAR. Brazilian Administration Review     Open Access   (Followers: 1, SJR: 0.188, h-index: 6)
Biota Neotropica     Open Access   (SJR: 0.373, h-index: 18)
Biotecnología Aplicada     Open Access   (SJR: 0.122, h-index: 10)
Biotecnología en el Sector Agropecuario y Agroindustrial     Open Access  
Boletim de Ciências Geodésicas     Open Access   (SJR: 0.227, h-index: 5)
Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas     Open Access   (Followers: 1, SJR: 0.139, h-index: 4)
Boletin Chileno de Parasitologia     Open Access  
Boletín de Filología     Open Access  
Boletín de la Sociedad Botánica de México     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Boletín de la Sociedad Geológica Mexicana     Open Access   (SJR: 0.231, h-index: 8)
Boletín del Museo Chileno de Arte Precolombino     Open Access   (Followers: 1, SJR: 0.149, h-index: 1)
Bosque     Open Access   (Followers: 2, SJR: 0.256, h-index: 10)
Bragantia     Open Access   (Followers: 2, SJR: 0.522, h-index: 20)
Brazilian Archives of Biology and Technology     Open Access   (Followers: 3, SJR: 0.242, h-index: 31)
Brazilian Dental J.     Open Access   (Followers: 2, SJR: 0.47, h-index: 34)
Brazilian J. of Biology     Open Access   (Followers: 3, SJR: 0.358, h-index: 35)
Brazilian J. of Chemical Engineering     Open Access   (Followers: 3, SJR: 0.424, h-index: 32)
Brazilian J. of Food Technology     Open Access   (Followers: 3)
Brazilian J. of Medical and Biological Research     Open Access   (SJR: 0.541, h-index: 70)
Brazilian J. of Microbiology     Open Access   (Followers: 3, SJR: 0.39, h-index: 38)
Brazilian J. of Oceanography     Open Access   (Followers: 1, SJR: 0.285, h-index: 13)
Brazilian J. of Oral Sciences     Open Access   (Followers: 1, SJR: 0.145, h-index: 6)
Brazilian J. of Physical Therapy     Open Access   (SJR: 0.466, h-index: 16)
Brazilian J. of Plant Physiology     Open Access   (Followers: 3, SJR: 0.452, h-index: 32)
Brazilian J. of Veterinary Research and Animal Science     Open Access   (Followers: 7, SJR: 0.184, h-index: 10)
Brazilian Oral Research     Open Access  
Brazilian Political Science Review     Open Access  
Bulletin of the World Health Organization     Open Access   (Followers: 17, SJR: 2.819, h-index: 123)
Caderno CRH     Open Access   (SJR: 0.102, h-index: 4)
Caderno de Estudos     Open Access  
Cadernos CEDES     Open Access   (Followers: 1, SJR: 0.111, h-index: 5)
Cadernos de Pesquisa     Open Access   (Followers: 2, SJR: 0.26, h-index: 8)
Cadernos de Saúde Pública     Open Access   (Followers: 1, SJR: 0.593, h-index: 55)
Cadernos de Tradução     Open Access  
Cadernos Metrópole     Open Access   (Followers: 1)
Cadernos Nietzsche     Open Access  
Cadernos Pagu     Open Access   (SJR: 0.179, h-index: 4)
Cadernos Saúde Coletiva     Open Access   (Followers: 1)
Calidad en la educación     Open Access   (Followers: 1)
Cerâmica     Open Access   (Followers: 4, SJR: 0.19, h-index: 11)
CES Medicina     Open Access  
Chilean J. of Agricultural Research     Open Access   (Followers: 1, SJR: 0.366, h-index: 15)
Chungara (Arica) - Revista de Antropologia Chilena     Open Access   (Followers: 1, SJR: 0.49, h-index: 13)
Ciência & Educação (Bauru)     Open Access  
Ciência & Saúde Coletiva     Open Access   (Followers: 2, SJR: 0.588, h-index: 30)
Ciência Animal Brasileira     Open Access   (Followers: 1, SJR: 0.322, h-index: 4)
Ciência da Informação     Open Access   (Followers: 1, SJR: 0.117, h-index: 7)
Ciencia del suelo     Open Access   (Followers: 2, SJR: 0.206, h-index: 13)
Ciência e Agrotecnologia     Open Access   (SJR: 0.444, h-index: 19)
Ciencia e Cultura     Open Access   (Followers: 1)
Ciencia e investigación agraria     Open Access   (Followers: 1, SJR: 0.21, h-index: 10)
Ciencia forestal en México     Open Access  
Ciência Rural     Open Access   (Followers: 2, SJR: 0.389, h-index: 24)
Ciencia y Enfermeria - Revista Iberoamericana de Investigacion     Open Access   (Followers: 3, SJR: 0.165, h-index: 7)
Ciencias Marinas     Open Access   (Followers: 2, SJR: 0.348, h-index: 21)
Ciencias Psicológicas     Open Access  
Cirugia Plastica Ibero-Latinoamericana     Open Access   (SJR: 0.175, h-index: 8)
CLEI Electronic J.     Open Access  
Clínica y Salud     Open Access   (SJR: 0.15, h-index: 3)
Clinics     Open Access   (SJR: 0.525, h-index: 36)
CoDAS     Open Access   (SJR: 0.177, h-index: 12)
Computación y Sistemas     Open Access   (SJR: 0.253, h-index: 4)
Comuni@cción     Open Access  
Comunicación y sociedad     Open Access   (Followers: 2, SJR: 0.104, h-index: 1)
Contaduría y Administración     Open Access   (SJR: 0.103, h-index: 1)
Contexto Internacional     Open Access  
Convergencia     Open Access   (SJR: 0.112, h-index: 4)
Correo Científico Médico     Open Access  
Corrosão e Protecção de Materiais     Open Access  
Crop Breeding and Applied Biotechnology     Open Access   (Followers: 4, SJR: 0.604, h-index: 13)
Cuadernos de Economía     Open Access   (Followers: 2)
Cuadernos de Economia - Latin American J. of Economics     Open Access   (Followers: 2)
Cuadernos de Historia     Open Access   (Followers: 3)
Cuadernos de Historia de la Salud Publica     Open Access  
Cuadernos de Medicina Forense     Open Access   (Followers: 2, SJR: 0.106, h-index: 4)
Cuadernos.info     Open Access   (SJR: 0.117, h-index: 2)
Cubo. A Mathematical J.     Open Access  
Cuicuilco     Open Access   (Followers: 1)
Cultivos Tropicales     Open Access  
Culturales     Open Access   (Followers: 2)
Dados - Revista de Ciências Sociais     Open Access   (SJR: 0.429, h-index: 15)
De Jure     Open Access   (Followers: 1)
DELTA : Documentação de Estudos em Lingüística Teórica e Aplicada     Open Access   (SJR: 0.142, h-index: 5)
Dementia & Neuropsychologia     Open Access   (Followers: 6, SJR: 0.232, h-index: 10)
Dental Press J. of Orthodontics     Open Access   (Followers: 2, SJR: 0.214, h-index: 7)
Desacatos     Open Access   (Followers: 1)
Desarrollo y Sociedad     Open Access   (Followers: 3, SJR: 0.106, h-index: 2)
Diálogo Andino - Revista de Historia, Geografía y Cultura Andina     Open Access  
Diánoia     Open Access   (Followers: 1)
Dimensión Empresarial     Open Access  
Dynamis : Acta Hispanica ad Medicinae Scientiarumque Historiam Illustrandam     Open Access   (Followers: 1, SJR: 0.134, h-index: 7)
e-J. of Portuguese History     Open Access   (Followers: 2, SJR: 0.125, h-index: 2)
Eclética Química     Open Access   (Followers: 1)
Ecología en Bolivia     Open Access  
Economia Aplicada     Open Access   (SJR: 0.168, h-index: 6)
Economia e Sociedade     Open Access  
EconoQuantum     Open Access  
Educação & Sociedade     Open Access   (Followers: 3, SJR: 0.244, h-index: 12)
Educação e Pesquisa     Open Access   (Followers: 1, SJR: 0.171, h-index: 8)
Educação em Revista     Open Access  
Educación Matemática     Open Access  
Educación Médica     Open Access   (Followers: 1, SJR: 0.11, h-index: 7)
Educación Médica Superior     Open Access   (Followers: 1, SJR: 0.188, h-index: 7)
Educación y Educadores     Open Access   (Followers: 1)
Educar em Revista     Open Access  
EDUMECENTRO     Open Access  
En-Claves del pensamiento     Open Access   (Followers: 1)
Encuentros     Open Access  
Ene : Revista de Enfermería     Open Access  
Enfermería Global     Open Access   (Followers: 3, SJR: 0.14, h-index: 2)
Enfermería Nefrológica     Open Access   (Followers: 1)
Engenharia Agrícola     Open Access   (SJR: 0.396, h-index: 18)
Engenharia Sanitaria e Ambiental     Open Access   (SJR: 0.15, h-index: 10)
Ensaio Avaliação e Políticas Públicas em Educação     Open Access   (Followers: 1, SJR: 0.19, h-index: 6)
Entomologia y Vectores     Open Access   (Followers: 2)
Escritos de Psicología : Psychological Writings     Open Access   (Followers: 2)
Estudios Atacameños     Open Access   (Followers: 2, SJR: 0.418, h-index: 8)
Estudios Constitucionales     Open Access   (Followers: 4, SJR: 0.383, h-index: 5)
Estudios de Cultura Maya     Open Access   (Followers: 3, SJR: 0.167, h-index: 1)
Estudios de Economía     Open Access   (SJR: 0.144, h-index: 7)
Estudios de historia moderna y contemporánea de México     Open Access   (SJR: 0.101, h-index: 3)
Estudios Filologicos     Open Access   (SJR: 0.105, h-index: 3)
Estudios Fronterizos     Open Access   (Followers: 1)
Estudios internacionales     Open Access   (Followers: 5)
Estudios Pedagogicos (Valdivia)     Open Access   (Followers: 2, SJR: 0.209, h-index: 7)
Estudios Políticos     Open Access  

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Journal Cover Clinics
  [SJR: 0.525]   [H-I: 36]   [0 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 1807-5932 - ISSN (Online) 1980-5322
   Published by SciELO Homepage  [717 journals]
  • Adherence to BCLC recommendations for the treatment of hepatocellular
           carcinoma: impact on survival according to stage

    • Abstract: OBJECTIVES: This study sought to assess the adherence of newly diagnosed hepatocellular carcinoma patients to the Barcelona Clinic Liver Cancer system treatment guidelines and to examine the impact of adherence on the survival of patients in different stages of the disease. METHODS: This study included all patients referred for the treatment of hepatocellular carcinoma between 2010 and 2012. Patients (n=364) were classified according to the Barcelona Clinic Liver Cancer guidelines. Deviations from the recommended guidelines were discussed, and treatment was determined by a multidisciplinary team. The overall survival curves were estimated with the Kaplan-Meier method and were compared using the log-rank test. RESULTS: The overall rate of adherence to the guidelines was 52%. The rate of adherence of patients in each scoring group varied as follows: stage 0, 33%; stage A, 45%; stage B, 78%; stage C, 35%; and stage D, 67%. In stage 0/A, adherent patients had a significantly better overall survival than non-adherent patients (hazard ratio=0.19, 95% confidence interval (CI): 0.09-0.42; p<0.001). Among the stage D patients, the overall survival rate was worse in adherent patients than in non-adherent patients (hazard ratio=4.0, 95% CI: 1.67-9.88; p<0.001), whereas no differences were observed in patients in stages B or C. CONCLUSIONS: The rate of adherence to the Barcelona Clinic Liver Cancer staging system in clinical practice varies according to clinical disease stage. Adherence to the recommended guidelines positively impacts survival, especially in patients with early-stage disease.
       
  • Independent early predictors of mortality in polytrauma patients: a
           prospective, observational, longitudinal study

    • Abstract: OBJECTIVES: Trauma is an important public health issue and associated with substantial socioeconomic impacts and major adverse clinical outcomes. No single study has previously investigated the predictors of mortality across all stages of care (pre-hospital, emergency room, surgical center and intensive care unit) in a general trauma population. This study was designed to identify early predictors of mortality in severely injured polytrauma patients across all stages of care to provide a better understanding of the physiologic changes and mechanisms by which to improve care in this population. METHODS: A longitudinal, prospective, observational study was conducted between 2010 and 2013 in São Paulo, Brazil. Patients submitted to high-energy trauma were included. Exclusion criteria were as follows: injury severity score <16, <18 years old or insufficient data. Clinical and laboratory data were collected at four time points: pre-hospital, emergency room, and 3 and 24 hours after hospital admission. The primary outcome assessed was mortality within 30 days. Data were analyzed using tests of association as appropriate, nonparametric analysis of variance and generalized estimating equation analysis (p<0.05). ClinicalTrials.gov: NCT01669577. RESULTS: Two hundred patients were included. Independent early predictors of mortality were as follows: arterial hemoglobin oxygen saturation (p<0.001), diastolic blood pressure (p<0.001), lactate level (p<0.001), Glasgow Coma Scale score (p<0.001), infused crystalloid volume (p<0.015) and presence of traumatic brain injury (p<0.001). CONCLUSION: Our results suggest that arterial hemoglobin oxygen saturation, diastolic blood pressure, lactate level, Glasgow Coma Scale, infused crystalloid volume and presence of traumatic brain injury are independent early mortality predictors.
       
  • Sensitivity of caloric test and video head impulse as screening test for
           chronic vestibular complaints

    • Abstract: OBJECTIVE: This study compared the results of the caloric test with those of the video head impulse test obtained during the same session and evaluated whether the former can be used to screen for non-acute vestibular dysfunction. METHODS: A total of 157 participants complaining of dizziness with vestibular characteristics of varying durations and clinical courses completed the caloric test and video head impulse test. RESULTS: Significantly more caloric test results than video head impulse test results were abnormal. CONCLUSIONS: The results of the caloric test and video head impulse test are distinct but complement each other. Within our sample, the caloric test was more sensitive for vestibular dysfunction. Therefore, the video head impulse test is not a suitable screening tool of the vestibular system in patients with chronic complaints.
       
  • High frequency of silent brain infarcts associated with cognitive deficits
           in an economically disadvantaged population

    • Abstract: OBJECTIVE: Using magnetic resonance imaging, we aimed to assess the presence of silent brain vascular lesions in a sample of apparently healthy elderly individuals who were recruited from an economically disadvantaged urban region (São Paulo, Brazil). We also wished to investigate whether the findings were associated with worse cognitive performance. METHODS: A sample of 250 elderly subjects (66-75 years) without dementia or neuropsychiatric disorders were recruited from predefined census sectors of an economically disadvantaged area of Sao Paulo and received structural magnetic resonance imaging scans and cognitive testing. A high proportion of individuals had very low levels of education (4 years or less, n=185; 21 with no formal education). RESULTS: The prevalence of at least one silent vascular-related cortical or subcortical lesion was 22.8% (95% confidence interval, 17.7-28.5), and the basal ganglia was the most frequently affected site (63.14% of cases). The subgroup with brain infarcts presented significantly lower levels of education than the subgroup with no brain lesions as well as significantly worse current performance in cognitive test domains, including memory and attention (p<0.002). CONCLUSIONS: Silent brain infarcts were present at a substantially high frequency in our elderly sample from an economically disadvantaged urban region and were significantly more prevalent in subjects with lower levels of education. Covert cerebrovascular disease significantly contributes to cognitive deficits, and in the absence of magnetic resonance imaging data, this cognitive impairment may be considered simply related to ageing. Emphatic attention should be paid to potentially deleterious effects of vascular brain lesions in poorly educated elderly individuals from economically disadvantaged environments.
       
  • A Comparative Study of Sagittal Balance in Patients with Neuromuscular
           Scoliosis

    • Abstract: OBJECTIVES: Spinopelvic alignment has been associated with improved quality of life in patients with vertebral deformities, and it helps to compensate for imbalances in gait. Although surgical treatment of scoliosis in patients with neuromuscular spinal deformities promotes correction of coronal scoliotic deformities, it remains poorly established whether this results in large changes in sagittal balance parameters in this specific population. The objective of this study is to compare these parameters before and after the current procedure under the hypothesis is that there is no significant modification. METHODS: Sampling included all records of patients with neuromuscular scoliosis with adequate radiographic records treated at Institute of Orthopedics and Traumatology of Clinics Hospital of University of São Paulo (IOT-HCFMUSP) from January 2009 to December 2013. Parameters analyzed were incidence, sacral inclination, pelvic tilt, lumbar lordosis, thoracic kyphosis, spinosacral angle, spinal inclination and spinopelvic inclination obtained using the iSite-Philips digital display system with Surgimap and a validated method for digital measurements of scoliosis radiographs. Comparison between the pre- and post-operative conditions involved means and standard deviations and the t-test. RESULTS: Based on 101 medical records only, 16 patients met the inclusion criteria for this study, including 7 males and 9 females, with an age range of 9-20 and a mean age of 12.9±3.06; 14 were diagnosed with cerebral palsy. No significant differences were found between pre and postoperative parameters. CONCLUSIONS: Despite correction of coronal scoliotic deformity in patients with neuromuscular deformities, there were no changes in spinopelvic alignment parameters in the group studied.
       
  • Community Care Administration of Spinal Deformities in the Brazilian
           Public Health System

    • Abstract: OBJECTIVE: Underfunding of the surgical treatment of complex spinal deformities has been an important reason for the steadily growing waiting lists in publicly funded healthcare systems. The aim of this study is to characterize the management of the treatment of spinal deformities in the public healthcare system. METHODS: A cross-sectional study of 60 patients with complex pediatric spinal deformities waiting for treatment in December 2013 was performed. The evaluated parameters were place of origin, waiting time until first assessment at a specialized spine care center, waiting time for the surgical treatment, and need for implants not reimbursed by the healthcare system. RESULTS: Ninety-one percent of the patients lived in São Paulo State (33% from Ribeirão Preto - DRS XIII). Patients waited for 0.5 to 48.0 months for referral, and the waiting times for surgery ranged from 2 to 117 months. Forty-five percent of the patients required implants for the surgical procedure that were not available. CONCLUSION: The current management of patients with spinal deformities in the public healthcare system does not provide adequate treatment for these patients in our region. They experience long waiting periods for referral and prolonged waiting times to receive surgical treatment; additionally, many of the necessary procedures are not reimbursed by the public healthcare system.
       
  • Selenocysteine modulates resistance to environmental stress and confers
           anti-aging effects in C. elegans

    • Abstract: OBJECTIVE: The free radical theory of aging suggests that cellular oxidative damage caused by free radicals is a leading cause of aging. In the present study, we examined the effects of a well-known anti-oxidant amino acid derivative, selenocysteine, in response to environmental stress and aging using Caenorhabditis elegans as a model system. METHOD: The response to oxidative stress induced by H2O2 or ultraviolet irradiation was compared between the untreated control and selenocysteine-treated groups. The effect of selenocysteine on lifespan and fertility was then determined. To examine the effect of selenocysteine on muscle aging, we monitored the change in motility with aging in both the untreated control and selenocysteine-treated groups. RESULTS: Dietary supplementation with selenocysteine significantly increased resistance to oxidative stress. Survival after ultraviolet irradiation was also increased by supplementation with selenocysteine. Treatment with selenocysteine confers a longevity phenotype without an accompanying reduction in fertility, which is frequently observed in lifespan-extending interventions as a trade-off in C. elegans. In addition, the age-related decline in motility was significantly delayed by supplementation of selenocysteine. CONCLUSION: These findings suggest that dietary supplementation of selenocysteine can modulate response to stressors and lead to lifespan extension, thus supporting the free radical theory of aging.
       
  • Systematic Review of Health Economic Evaluations of Diagnostic Tests in
           Brazil: How accurate are the results'

    • Abstract: The aim of this study is to identify and characterize the health economic evaluations (HEEs) of diagnostic tests conducted in Brazil, in terms of their adherence to international guidelines for reporting economic studies and specific questions in test accuracy reports. We systematically searched multiple databases, selecting partial and full HEEs of diagnostic tests, published between 1980 and 2013. Two independent reviewers screened articles for relevance and extracted the data. We performed a qualitative narrative synthesis. Forty-three articles were reviewed. The most frequently studied diagnostic tests were laboratory tests (37.2%) and imaging tests (32.6%). Most were non-invasive tests (51.2%) and were performed in the adult population (48.8%). The intended purposes of the technologies evaluated were mostly diagnostic (69.8%), but diagnosis and treatment and screening, diagnosis, and treatment accounted for 25.6% and 4.7%, respectively. Of the reviewed studies, 12.5% described the methods used to estimate the quantities of resources, 33.3% reported the discount rate applied, and 29.2% listed the type of sensitivity analysis performed. Among the 12 cost-effectiveness analyses, only two studies (17%) referred to the application of formal methods to check the quality of the accuracy studies that provided support for the economic model. The existing Brazilian literature on the HEEs of diagnostic tests exhibited reasonably good performance. However, the following points still require improvement: 1) the methods used to estimate resource quantities and unit costs, 2) the discount rate, 3) descriptions of sensitivity analysis methods, 4) reporting of conflicts of interest, 5) evaluations of the quality of the accuracy studies considered in the cost-effectiveness models, and 6) the incorporation of accuracy measures into sensitivity analyses.
       
  • Hypothalamic transcriptional expression of the kisspeptin system and sex
           steroid receptors differs among polycystic ovary syndrome rat models with
           different endocrine phenotypes

    • Abstract: OBJECTIVES: Polycystic ovary syndrome is a heterogeneous endocrine disorder that affects reproductive-age women. The mechanisms underlying the endocrine heterogeneity and neuroendocrinology of polycystic ovary syndrome are still unclear. In this study, we investigated the expression of the kisspeptin system and gonadotropin-releasing hormone pulse regulators in the hypothalamus as well as factors related to luteinizing hormone secretion in the pituitary of polycystic ovary syndrome rat models induced by testosterone or estradiol. METHODS: A single injection of testosterone propionate (1.25 mg) (n=10) or estradiol benzoate (0.5 mg) (n=10) was administered to female rats at 2 days of age to induce experimental polycystic ovary syndrome. Controls were injected with a vehicle (n=10). Animals were euthanized at 90-94 days of age, and the hypothalamus and pituitary gland were used for gene expression analysis. RESULTS: Rats exposed to testosterone exhibited increased transcriptional expression of the androgen receptor and estrogen receptor-β and reduced expression of kisspeptin in the hypothalamus. However, rats exposed to estradiol did not show any significant changes in hormone levels relative to controls but exhibited hypothalamic downregulation of kisspeptin, tachykinin 3 and estrogen receptor-α genes and upregulation of the gene that encodes the kisspeptin receptor. CONCLUSIONS: Testosterone- and estradiol-exposed rats with different endocrine phenotypes showed differential transcriptional expression of members of the kisspeptin system and sex steroid receptors in the hypothalamus. These differences might account for the different endocrine phenotypes found in testosterone- and estradiol-induced polycystic ovary syndrome rats.
       
  • ERRATA

    • Abstract: OBJECTIVES: Polycystic ovary syndrome is a heterogeneous endocrine disorder that affects reproductive-age women. The mechanisms underlying the endocrine heterogeneity and neuroendocrinology of polycystic ovary syndrome are still unclear. In this study, we investigated the expression of the kisspeptin system and gonadotropin-releasing hormone pulse regulators in the hypothalamus as well as factors related to luteinizing hormone secretion in the pituitary of polycystic ovary syndrome rat models induced by testosterone or estradiol. METHODS: A single injection of testosterone propionate (1.25 mg) (n=10) or estradiol benzoate (0.5 mg) (n=10) was administered to female rats at 2 days of age to induce experimental polycystic ovary syndrome. Controls were injected with a vehicle (n=10). Animals were euthanized at 90-94 days of age, and the hypothalamus and pituitary gland were used for gene expression analysis. RESULTS: Rats exposed to testosterone exhibited increased transcriptional expression of the androgen receptor and estrogen receptor-β and reduced expression of kisspeptin in the hypothalamus. However, rats exposed to estradiol did not show any significant changes in hormone levels relative to controls but exhibited hypothalamic downregulation of kisspeptin, tachykinin 3 and estrogen receptor-α genes and upregulation of the gene that encodes the kisspeptin receptor. CONCLUSIONS: Testosterone- and estradiol-exposed rats with different endocrine phenotypes showed differential transcriptional expression of members of the kisspeptin system and sex steroid receptors in the hypothalamus. These differences might account for the different endocrine phenotypes found in testosterone- and estradiol-induced polycystic ovary syndrome rats.
       
 
 
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