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Publisher: SciELO   (Total: 711 journals)

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ABCD. Arquivos Brasileiros de Cirurgia Digestiva     Open Access   (Followers: 4)
ACIMED     Open Access   (SJR: 0.14, h-index: 4)
Acta Amazonica     Open Access   (Followers: 2, SJR: 0.452, h-index: 11)
Acta Bioethica     Open Access   (Followers: 2, SJR: 0.206, h-index: 3)
Acta Bioquimica Clinica Latinoamericana     Open Access   (Followers: 1, SJR: 0.183, h-index: 6)
Acta Botanica Brasilica     Open Access   (Followers: 2, SJR: 0.337, h-index: 14)
Acta botánica mexicana     Open Access   (SJR: 0.172, h-index: 3)
Acta Cirurgica Brasileira     Open Access   (SJR: 0.228, h-index: 13)
Acta Limnologica Brasiliensia     Open Access   (Followers: 1)
Acta Literaria     Open Access   (Followers: 2, SJR: 0.1, h-index: 1)
Acta Médica Costarricense     Open Access  
Acta Medica Peruana     Open Access   (Followers: 2)
Acta Neurológica Colombiana     Open Access   (Followers: 1)
Acta Ortopédica Brasileira     Open Access   (Followers: 2, SJR: 0.145, h-index: 8)
Acta Paulista de Enfermagem     Open Access   (Followers: 1, SJR: 0.35, h-index: 9)
Acta Pediátrica Costarricense     Open Access   (Followers: 1)
Acta Scientiarum. Agronomy     Open Access   (Followers: 3, SJR: 0.508, h-index: 10)
Acta Toxicológica Argentina     Open Access  
Acta zoológica mexicana     Open Access  
Actualidades Biológicas     Open Access  
African Human Rights Law J.     Open Access   (Followers: 17)
African Natural History     Open Access   (Followers: 1)
Afro-Asia     Open Access  
Ágora - studies in psychoanalytic theory     Open Access   (Followers: 2, SJR: 0.1, h-index: 1)
Agricultura Tecnica     Open Access   (Followers: 6)
Agrociencia     Open Access   (Followers: 2, SJR: 0.195, h-index: 11)
Agronomía Costarricense     Open Access   (Followers: 2)
Agronomía Mesoamericana     Open Access   (Followers: 1)
Aisthesis     Open Access  
Alea : Estudos Neolatinos     Open Access   (Followers: 1, SJR: 0.129, h-index: 2)
Alpha (Osorno)     Open Access  
Ambiente & sociedade     Open Access   (Followers: 2, SJR: 0.146, h-index: 4)
Ambiente Construído     Open Access   (Followers: 2)
América Latina en la historia económica     Open Access   (Followers: 1)
Anais Brasileiros de Dermatologia     Open Access   (Followers: 1, SJR: 0.342, h-index: 13)
Anais da Academia Brasileira de Ciências     Open Access   (Followers: 2)
Anais do Museu Paulista : História e Cultura Material     Open Access   (Followers: 1)
Anales de Medicina Interna     Open Access   (Followers: 1)
Anales del Instituto de la Patagonia     Open Access   (Followers: 2)
Anales del Sistema Sanitario de Navarra     Open Access   (SJR: 0.165, h-index: 13)
Analisis Politico     Open Access   (Followers: 3, SJR: 0.1, h-index: 1)
Andean geology     Open Access   (Followers: 5, SJR: 0.604, h-index: 20)
Angiologia e Cirurgia Vascular     Open Access  
Annali dell'Istituto Superiore di Sanità     Open Access   (SJR: 0.269, h-index: 23)
Anuario Colombiano de Historia Social y de la Cultura     Open Access   (Followers: 1)
Apuntes : Revista de Estudios sobre Patrimonio Cultural - J. of Cultural Heritage Studies     Open Access   (Followers: 3)
Archivos de cardiología de México     Open Access   (Followers: 1, SJR: 0.119, h-index: 11)
Archivos de Medicina Veterinaria     Open Access   (Followers: 1, SJR: 0.271, h-index: 12)
Archivos de Neurociencias     Open Access   (Followers: 2)
Archivos de Pediatria del Uruguay     Open Access   (Followers: 1)
Archivos de Zootecnia     Open Access   (Followers: 2, SJR: 0.219, h-index: 4)
Archivos Españoles de Urología     Open Access   (SJR: 0.195, h-index: 15)
Archivos Venezolanos de Farmacología y Terapéutica     Open Access   (Followers: 1, SJR: 0.102, h-index: 2)
Argos     Open Access   (Followers: 2, SJR: 0.1, h-index: 1)
ARQ     Open Access   (Followers: 4, SJR: 0.1, h-index: 1)
Arquivo Brasileiro de Medicina Veterinária e Zootecnia     Open Access   (Followers: 1, SJR: 0.312, h-index: 16)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 1, SJR: 0.253, h-index: 25)
Arquivos Brasileiros de Endocrinologia e Metabologia     Open Access   (SJR: 0.329, h-index: 21)
Arquivos Brasileiros de Oftalmologia     Open Access   (SJR: 0.313, h-index: 13)
Arquivos de Gastroenterologia     Open Access   (Followers: 1, SJR: 0.24, h-index: 16)
Arquivos de Neuro-Psiquiatria     Open Access   (SJR: 0.281, h-index: 30)
Arquivos do Instituto Biológico     Open Access  
Arquivos Internacionais de Otorrinolaringologia     Open Access  
ARS     Open Access   (Followers: 1)
Atenea (Concepción)     Open Access   (Followers: 1)
Atmósfera     Open Access   (SJR: 0.485, h-index: 13)
Audiology - Communication Research     Open Access   (Followers: 3)
Avaliação : Revista da Avaliação da Educação Superior (Campinas)     Open Access  
Avances en Odontoestomatologia     Open Access   (SJR: 0.102, h-index: 3)
Avances en Periodoncia e Implantología Oral     Open Access   (Followers: 4)
Bakhtiniana : Revista de Estudos do Discurso     Open Access  
BAR. Brazilian Administration Review     Open Access   (SJR: 0.136, h-index: 3)
Biocell     Open Access   (Followers: 1, SJR: 0.232, h-index: 17)
Biological Research     Open Access   (SJR: 0.297, h-index: 32)
Biota Neotropica     Open Access   (SJR: 0.363, h-index: 10)
Boletim de Ciências Geodésicas     Open Access   (SJR: 0.195, h-index: 4)
Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas     Open Access   (Followers: 1)
Boletin Chileno de Parasitologia     Open Access  
Boletín de Filología     Open Access  
Boletín de Historia Argentina y Americana Dr. Emilio Ravignani     Open Access   (Followers: 1)
Boletin de la Sociedad Argentina de Botanica     Open Access   (Followers: 1)
Boletín de la Sociedad Botánica de México     Open Access   (SJR: 0.166, h-index: 4)
Boletin de la Sociedad Chilena de Quimica     Open Access  
Boletín de la Sociedad Geológica Mexicana     Open Access   (SJR: 0.252, h-index: 5)
Boletín del Museo Chileno de Arte Precolombino     Open Access   (Followers: 1)
Bosque     Open Access   (Followers: 1, SJR: 0.18, h-index: 6)
Bragantia     Open Access   (Followers: 2, SJR: 0.445, h-index: 16)
Brazilian Archives of Biology and Technology     Open Access   (Followers: 1, SJR: 0.309, h-index: 21)
Brazilian Dental J.     Open Access   (Followers: 2, SJR: 0.408, h-index: 25)
Brazilian J. of Biology     Open Access   (Followers: 3, SJR: 0.438, h-index: 26)
Brazilian J. of Chemical Engineering     Open Access   (Followers: 2, SJR: 0.419, h-index: 22)
Brazilian J. of Food Technology     Open Access   (Followers: 2)
Brazilian J. of Medical and Biological Research     Open Access   (SJR: 0.213, h-index: 56)
Brazilian J. of Microbiology     Open Access   (Followers: 2, SJR: 0.379, h-index: 27)
Brazilian J. of Oceanography     Open Access   (Followers: 3, SJR: 0.289, h-index: 6)
Brazilian J. of Oral Sciences     Open Access   (Followers: 1, SJR: 0.143, h-index: 4)
Brazilian J. of Physical Therapy     Open Access   (SJR: 0.369, h-index: 8)
Brazilian J. of Plant Physiology     Open Access   (Followers: 4, SJR: 0.245, h-index: 27)
Brazilian J. of Veterinary Research and Animal Science     Open Access   (Followers: 7, SJR: 0.18, h-index: 7)
Brazilian Oral Research     Open Access  

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Journal Cover Acta Toxicológica Argentina
   Follow    
  This is an Open Access Journal Open Access journal
     ISSN (Print) 0327-9286 - ISSN (Online) 1851-3743
     Published by SciELO Homepage  [711 journals]
  • Severe poisoning by valproic acid

    • Abstract: El ácido valproico es utilizado en el manejo de las crisis de ausencias simples y complejas, mioclonías y convulsiones tónico-clónicas generalizadas. Es efectivo en las crisis parciales, como profilaxis de segunda línea para la migraña y en el trastorno bipolar. Debido a su amplio uso han aumentado los casos de intoxicación en los últimos años. Los objetivos de este trabajo son describir las manifestaciones clínicas y evolución de una intoxicación severa por ácido valproico, secundaria a ingesta intencional; destacar la importancia del metabolismo de la droga para el manejo clínico de la intoxicación, la necesidad de un laboratorio capaz de proporcionar una rápida cuantificación de la misma y analizar las opciones terapéuticas actuales.Valproic acid is used in crisis management both simple and complex absence, myoclonus and tonic-clonic seizures. It is effective in partial seizures, as second line prophylaxis for migraine and bipolar disorder. Its widespread use has increased cases of poisoning in recent years. The aim of this review is to describe the clinical manifestations and evolution of a severe valproic acid intoxication secondary to intentional consumption as well as emphasize the importance of drug metabolism for clinical management of poisoning, the need for a laboratory provide rapid quantification of this drug and discuss current treatment options.
       
  • Optimization in the immunoglobulins recovery, as whole molecule and
           F(ab´)2 fragment, in the antivenim production

    • Abstract: En la actualidad se utilizan, principalmente, dos métodos de purificación de anticuerpos a partir de plasmas equinos hiperinmunes para la producción de antivenenos a nivel industrial, obteniéndose preparaciones enriquecidas en moléculas de inmunoglobulinas G ó fragmentos F(ab´)2. Con ambos métodos, luego de la precipitación, se observa una importante pérdida de capacidad neutralizante en comparación con la capacidad neutralizante de los plasmas de partida. En este trabajo, se realizó el fraccionamiento de plasmas equinos hiperinmunes utilizando ácido caprílico con y sin digestión enzimática con pepsina. El objetivo del trabajo fue dar a conocer la proporción de recuperación de la capacidad neutralizante luego del fraccionamiento; resultando ésta menor cuando el plasma se trató enzimáticamente. Adicionalmente, se propuso establecer cuál sería la etapa responsable de la diferencia en la recuperación de anticuerpos entre una metodología y otra. Cuando se purificaron las inmunoglobulinas enteras, se recuperó aproximadamente un 53% de la capacidad neutralizante mientras que cuando la muestra se purificó luego de ser tratada enzimáticamente, se obtuvo alrededor del 30% de esa actividad. Una relación de similar magnitud se verifica en la recuperación de la masa de proteínas solubles luego de remover los contaminantes, entre una metodología y otra. La insolubilización del fragmento Fc generado durante la digestión sería el responsable de esa pérdida adicional de proteína y capacidad neutralizante.Today two methods are mainly used for the purification of antibodies from hyperimmune equine plasma at industrial level obtaining enriched preparations of immunoglobulin G (IgG) molecules or F(ab´)2 fragments. In both methods, after the precipitation, an important loss in the neutralizing capability was observed compared to the one of the original plasma. In this work, we performed the fractionation of hyperimmune equine plasma using caprylic acid, with and without enzymatic digestion with pepsin. The aim was to explain the percentage of recovery of the neutralizing capability after the fractionation; which resulted minor when the plasma was enzymatically treated. Additionally, we intended to establish which stage, in the purification process, was the responsible for the difference in the antibody recovery between one methodology and the other. When entire immunoglobulins were purified, approximately 53% of the neutralizing capacity was recovered, but when the sample was purified after the enzymatic treatment, around the 30% of the activity was obtained. A ratio of similar magnitude is verified on the recovery of the soluble protein mass after the removal of contaminants, between the two methods. The insolubilization of the fragment Fc generated during digestion would be responsible for the additional loss of protein and neutralizing capacity.
       
  • Cytotoxic and antiparasitic in vitro activities of
           
    a -pinene and carvacrol

    • Abstract: A leishmaniose e a doença de Chagas tem sido um grande desafio, no que diz respeito à sua terapêutica. Devido à grande dificuldade de encontrar fármacos que garantam uma ação terapêutica eficiente e menos agressora à espécie humana, diferentes produtos naturais vêm sendo testados. Muitas espécies vegetais foram investigadas quanto à sua ação leishmanicida e tripanocida na expectativa de que seus compostos metabólicos possuam atividade antiparasitária e ausência ou baixa citotoxicidade. Neste estudo sobre bioatividade do a-pineno e carvacrol, avaliaram-se os potenciais leishmanicida e tripanocida. O carvacrol apresentou um percentual de inibição de 38,34% e 74,12% para as formas promastigotas e epimastigotas respectivamente, na concentração de 100µg/mL, apresentando uma citotoxicidade de 21,62%. O a-pineno apresentou 100% e 5,30% de inibição para as formas epimastigota e promastigota na concentração de 100 µg/mL, com citotoxicidade de 87,88%.Leishmaniasis and Chagas Disease represent a great challenge against the modern therapeutics. Due the high difficult to find new drugs with therapeutic efficacy and low toxicity, several natural products had been screened. Many species of plants were investigated about their leishmanicidal and trypanocidal activities. Some phytocompounds are the a-pinene and carvacrol. In this work, we evaluated the bioactivities of a-pinene and carvacrol against Trypanosoma cruzi and Leishmania braziliensis cell lines. The carvacrol inhibited 38,34% and 74,12% of the promatigote and epimastigote forms, respectively at 100 µg/mL, showing a low cytotoxic activity (21,62%). The O a-pinene inhibited 100% and 5,30% against the epimastigote and promastigote forms respectively, at 100 µg/mL, showing a higher cytotoxic activity (87,88%).
       
  • Cytotoxicity of the food additive annatto and turmeric
           

    • Abstract: Este trabalho teve por objetivo avaliar a ação dos aditivos alimentares urucum e cúrcuma em células meristemáticas de pontas de raízes de Allium cepa nas doses de 5 e 10 g, nos tempos de exposição de 24 e 48 horas. Utilizou-se para cada dose um grupo de cinco bulbos de cebolas, que primeiramente foram enraizados em água destilada, e em seguida transferidos para as suas respectivas doses. Analisaram-se células em todo ciclo celular, totalizando 5.000 para cada controle e tempo de exposição. Os dados obtidos foram submetidos à análise estatística do Qui-quadrado (p
       
 
 
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