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Showing 201 - 400 of 896 Journals sorted alphabetically
Cuadernos de Psicologia del Deporte     Open Access   (SJR: 0.423, CiteScore: 1)
Cuadernos del CENDES     Open Access   (SJR: 0.109, CiteScore: 0)
Cuadernos.info     Open Access   (SJR: 0.38, CiteScore: 0)
Cubo. A Mathematical J.     Open Access  
Cuestiones Constitucionales     Open Access   (Followers: 2, SJR: 0.1, CiteScore: 0)
Cuicuilco     Open Access   (Followers: 1)
Cuicuilco. Revista de Ciencias Antropológicas     Open Access   (Followers: 1)
Cultivos Tropicales     Open Access   (Followers: 1)
Cultura y Representaciones Sociales     Open Access   (Followers: 1)
Culturales     Open Access   (Followers: 3)
Dados - Revista de Ciências Sociais     Open Access   (SJR: 0.37, CiteScore: 0)
De Jure     Open Access   (Followers: 1)
DELTA : Documentação de Estudos em Lingüística Teórica e Aplicada     Open Access   (SJR: 0.133, CiteScore: 0)
Dementia & Neuropsychologia     Open Access   (Followers: 10, SJR: 0.205, CiteScore: 0)
Dental Press J. of Orthodontics     Open Access   (Followers: 5, SJR: 0.489, CiteScore: 1)
Desacatos     Open Access   (Followers: 1)
Desacatos : Revista de Antropología Social     Open Access   (Followers: 1)
Desarrollo y Sociedad     Open Access   (Followers: 3, SJR: 0.109, CiteScore: 0)
Diálogo Andino - Revista de Historia, Geografía y Cultura Andina     Open Access   (Followers: 1, SJR: 0.116, CiteScore: 0)
Diánoia     Open Access   (Followers: 1)
Dimensión Empresarial     Open Access  
Discusiones Filosóficas     Open Access   (Followers: 1)
Dynamis : Acta Hispanica ad Medicinae Scientiarumque Historiam Illustrandam     Open Access   (Followers: 3, SJR: 0.131, CiteScore: 0)
e-J. of Portuguese History     Open Access   (Followers: 2, SJR: 0.101, CiteScore: 0)
e-Pública : Revista Eletrónica de Direito Público     Open Access   (Followers: 1)
Earth Sciences Research J.     Open Access   (Followers: 1)
Eclética Química     Open Access   (Followers: 1)
Ecología en Bolivia     Open Access  
Economia Aplicada     Open Access   (SJR: 0.208, CiteScore: 0)
Economia e Sociedade     Open Access  
EconoQuantum     Open Access  
Educação & Sociedade     Open Access   (Followers: 3)
Educação e Pesquisa     Open Access   (Followers: 1, SJR: 0.163, CiteScore: 0)
Educação em Revista     Open Access  
Educación Matemática     Open Access  
Educación Médica     Open Access   (Followers: 1, SJR: 0.236, CiteScore: 0)
Educación Médica Superior     Open Access   (Followers: 1, SJR: 0.237, CiteScore: 0)
Educación y Educadores     Open Access  
Educar em Revista     Open Access  
EDUMECENTRO     Open Access  
Eidos     Open Access   (SJR: 0.119, CiteScore: 0)
En-Claves del pensamiento     Open Access   (Followers: 1, SJR: 0.194, CiteScore: 0)
Encuentros     Open Access  
Ene : Revista de Enfermería     Open Access  
Enfermería Global     Open Access   (Followers: 3, SJR: 0.165, CiteScore: 0)
Enfermería Nefrológica     Open Access   (Followers: 1, SJR: 0.198, CiteScore: 0)
Enfoques     Open Access  
Engenharia Agrícola     Open Access   (SJR: 0.305, CiteScore: 1)
Engenharia Sanitaria e Ambiental     Open Access   (SJR: 0.218, CiteScore: 0)
Ensaio Avaliação e Políticas Públicas em Educação     Open Access   (Followers: 1, SJR: 0.254, CiteScore: 0)
Ensayos de Economía     Open Access   (Followers: 1)
Ensayos Revista de Economía     Open Access   (Followers: 1)
Entomologia y Vectores     Open Access   (Followers: 2)
Entre Ciencia e Ingeniería     Open Access   (Followers: 1)
Epidemiologia e Serviços de Saúde     Open Access  
Escritos de Psicología : Psychological Writings     Open Access   (Followers: 2)
Estudios Atacameños     Open Access   (Followers: 2, SJR: 0.446, CiteScore: 1)
Estudios Constitucionales     Open Access   (Followers: 5, SJR: 0.319, CiteScore: 0)
Estudios de Cultura Maya     Open Access   (Followers: 2, SJR: 0.272, CiteScore: 0)
Estudios de Economía     Open Access   (SJR: 0.121, CiteScore: 0)
Estudios de historia moderna y contemporánea de México     Open Access   (SJR: 0.101, CiteScore: 0)
Estudios Economicos     Open Access  
Estudios Filologicos     Open Access   (SJR: 0.107, CiteScore: 0)
Estudios Fronterizos     Open Access   (Followers: 1)
Estudios internacionales     Open Access   (Followers: 5)
Estudios Pedagogicos (Valdivia)     Open Access   (Followers: 1, SJR: 0.338, CiteScore: 0)
Estudios Políticos     Open Access  
Estudios Sociales     Open Access   (Followers: 2)
Estudios sociales : Revista de alimentación contemporánea y desarrollo regional     Open Access   (Followers: 1)
Estudios Socioterritoriales : Revista de Geografía     Open Access  
Estudios y Perspectivas en Turismo     Open Access   (Followers: 2)
Estudos Afro-Asiáticos     Open Access   (Followers: 2)
Estudos Avançados     Open Access   (SJR: 0.232, CiteScore: 0)
Estudos de Psicologia (Campinas)     Open Access   (Followers: 1, SJR: 0.233, CiteScore: 0)
Estudos de Psicologia (Natal)     Open Access   (SJR: 0.117, CiteScore: 0)
Estudos Econômicos     Open Access   (SJR: 0.204, CiteScore: 0)
Estudos Históricos     Open Access   (Followers: 1)
EURE (Santiago) - Revista Latinoamericana de Estudios Urbano Regionales     Open Access   (SJR: 0.38, CiteScore: 1)
Ex aequo     Open Access  
FEM : Revista de la Fundación Educación Médica     Open Access  
Fides et Ratio : Revista de Difusión Cultural y Científica     Open Access   (Followers: 1)
Fisioterapia e Pesquisa     Open Access  
Fisioterapia em Movimento     Open Access  
Fitosanidad     Open Access  
Floresta e Ambiente     Open Access   (Followers: 1, SJR: 0.3, CiteScore: 0)
Folios     Open Access  
Food Science and Technology (Campinas)     Open Access   (Followers: 1, SJR: 0.467, CiteScore: 1)
Formación Universitaria     Open Access   (Followers: 4, SJR: 0.213, CiteScore: 1)
Frónesis     Open Access   (Followers: 1)
Frontera Norte     Open Access  
Gaceta Médica Boliviana     Open Access  
Gaceta Médica Espirituana     Open Access  
Galáxia (São Paulo)     Open Access  
Gayana (Concepcion)     Open Access   (SJR: 0.236, CiteScore: 0)
Gayana. Botanica     Open Access   (SJR: 0.234, CiteScore: 0)
Genetics and Molecular Biology     Open Access   (Followers: 15, SJR: 0.638, CiteScore: 2)
Geofísica internacional     Open Access   (SJR: 0.312, CiteScore: 1)
Gerokomos     Open Access   (Followers: 1, SJR: 0.257, CiteScore: 0)
Gestão & Produção     Open Access   (SJR: 0.156, CiteScore: 0)
Gestión y Política Pública     Open Access   (Followers: 2, SJR: 0.106, CiteScore: 0)
Hacia la Promoción de la Salud     Open Access  
Hallazgos     Open Access   (Followers: 1)
Hidrobiológica     Open Access   (SJR: 0.166, CiteScore: 0)
Historia     Open Access   (Followers: 2)
Historia (Santiago)     Open Access   (Followers: 1, SJR: 0.162, CiteScore: 0)
História (São Paulo)     Open Access   (SJR: 0.11, CiteScore: 0)
História, Ciências, Saúde - Manguinhos     Open Access   (Followers: 2, SJR: 0.144, CiteScore: 0)
Hoehnea     Open Access  
Horizonte Sanitario     Open Access   (Followers: 1)
Horizontes Antropológicos     Open Access   (Followers: 3, SJR: 0.233, CiteScore: 0)
Horticultura Brasileira     Open Access   (SJR: 0.605, CiteScore: 1)
HTS Theological Studies     Open Access   (Followers: 8, SJR: 0.448, CiteScore: 0)
Humanidades Médicas     Open Access  
IDESIA : Revista de Agricultura en Zonas Áridas     Open Access   (SJR: 0.223, CiteScore: 0)
Iheringia. Série Zoologia     Open Access   (Followers: 1, SJR: 0.26, CiteScore: 1)
Íkala : Revista de Lenguaje y Cultura     Open Access   (SJR: 0.112, CiteScore: 0)
Image & Text     Open Access   (Followers: 1)
Index de Enfermeria     Open Access   (Followers: 6, SJR: 0.113, CiteScore: 0)
Indo-Pacific J. of Phenomenology     Open Access   (Followers: 1)
Infectio     Open Access   (SJR: 0.133, CiteScore: 0)
Información Tecnológica     Open Access   (SJR: 0.197, CiteScore: 0)
Ingeniare : Revista Chilena de Ingenieria     Open Access   (Followers: 1, SJR: 0.239, CiteScore: 0)
Ingeniería Electrónica, Automática y Comunicaciones     Open Access  
Ingeniería Hidráulica y Ambiental     Open Access  
Ingeniería Industrial     Open Access  
Ingeniería Mecánica     Open Access   (Followers: 4)
Ingenieria Mecánica. Tecnologia y Desarrollo     Open Access   (Followers: 3)
Ingeniería y Competitividad     Open Access  
Ingenieria y Universidad     Open Access   (Followers: 1, SJR: 0.161, CiteScore: 1)
Ingeniería, Investigación y Tecnología     Open Access   (Followers: 1)
Innovar     Open Access   (SJR: 0.118, CiteScore: 0)
Interações (Campo Grande)     Open Access  
Interface - Comunicação, Saúde, Educação     Open Access   (Followers: 1, SJR: 0.417, CiteScore: 0)
Intersticios Sociales     Open Access   (Followers: 1)
Intervención     Open Access   (Followers: 1)
Intervención Psicosocial     Open Access   (SJR: 0.381, CiteScore: 1)
Intl. Brazilian J. of Urology     Open Access   (Followers: 4, SJR: 0.367, CiteScore: 1)
Intl. J. of Morphology     Open Access  
Intl. J. of Odontostomatology     Open Access   (Followers: 1)
Intl. Law: Revista Colombiana de Derecho Internacional     Open Access   (Followers: 3)
Investigación Administrativa     Open Access   (Followers: 1)
Investigación Bibliotecológica     Open Access   (Followers: 6, SJR: 0.274, CiteScore: 0)
Investigación Económica     Open Access   (Followers: 4, SJR: 0.132, CiteScore: 0)
Investigación y Desarrollo     Open Access   (Followers: 1)
Investigación y Educación en Enfermería     Open Access   (Followers: 1, SJR: 0.198, CiteScore: 0)
Investigaciones Geográficas     Open Access   (SJR: 0.246, CiteScore: 0)
Investigaciones Marinas     Open Access  
Iteckne     Open Access  
Iuris Tantum Revista Boliviana de Derecho     Open Access  
Ius et Praxis     Open Access   (SJR: 0.283, CiteScore: 0)
Izquierdas     Open Access   (SJR: 0.188, CiteScore: 0)
Iztapalapa : Revista de ciencias sociales y humanidades     Open Access   (Followers: 1)
J. of Applied Oral Science     Open Access   (SJR: 0.645, CiteScore: 2)
J. of Applied Research and Technology     Open Access   (SJR: 0.255, CiteScore: 1)
J. of Coloproctology     Open Access   (SJR: 0.167, CiteScore: 0)
J. of Energy in Southern Africa     Open Access   (Followers: 3, SJR: 0.249, CiteScore: 1)
J. of Epilepsy and Clinical Neurophysiology     Open Access   (Followers: 7)
J. of Microwaves, Optoelectronics and Electromagnetic Applications     Open Access   (Followers: 11, SJR: 0.146, CiteScore: 1)
J. of Seed Science     Open Access   (Followers: 1)
J. of Soil Science and Plant Nutrition     Open Access   (Followers: 11, SJR: 0.823, CiteScore: 2)
J. of Technology Management & Innovation     Open Access   (Followers: 5, SJR: 0.271, CiteScore: 1)
J. of the Brazilian Chemical Society     Open Access   (Followers: 2, SJR: 0.357, CiteScore: 1)
J. of the Brazilian Society of Mechanical Sciences     Open Access   (Followers: 2)
J. of the Chilean Chemical Society     Open Access   (Followers: 2, SJR: 0.201, CiteScore: 1)
J. of the Mexican Chemical Society     Open Access   (Followers: 2, SJR: 0.214, CiteScore: 1)
J. of the Selva Andina Research Society     Open Access   (Followers: 3)
J. of the South African Institution of Civil Engineering     Open Access   (Followers: 2, SJR: 0.174, CiteScore: 0)
J. of the Southern African Institute of Mining and Metallurgy     Open Access   (Followers: 6)
J. of Venomous Animals and Toxins     Open Access   (Followers: 2)
JISTEM : J. of Information Systems and Technology Management     Open Access   (Followers: 7)
Jornal Brasileiro de Nefrologia     Open Access   (SJR: 0.334, CiteScore: 1)
Jornal Brasileiro de Patologia e Medicina Laboratorial     Open Access   (SJR: 0.143, CiteScore: 0)
Jornal Brasileiro de Pneumologia     Open Access   (SJR: 0.448, CiteScore: 1)
Jornal Brasileiro de Psiquiatria     Open Access   (Followers: 2, SJR: 0.224, CiteScore: 0)
Jornal da Sociedade Brasileira de Fonoaudiologia     Open Access  
Jornal de Pneumologia     Open Access  
Jornal Vascular Brasileiro     Open Access   (SJR: 0.136, CiteScore: 0)
Justicia Juris     Open Access  
Kriterion: Revista de Filosofia     Open Access   (Followers: 1, SJR: 0.114, CiteScore: 0)
Kronos : Southern African Histories     Open Access   (Followers: 6)
La ventana. Revista de estudios de género     Open Access  
La zaranda de ideas     Open Access   (Followers: 1)
Laboreal     Open Access  
Lankesteriana     Open Access   (SJR: 0.458, CiteScore: 1)
Latin American Applied Research     Open Access   (Followers: 1)
Latin American J. of Aquatic Research     Open Access   (SJR: 0.289, CiteScore: 1)
Latin American J. of Economics     Open Access   (Followers: 1, SJR: 0.127, CiteScore: 0)
Latin American J. of Solids and Structures     Open Access   (Followers: 4, SJR: 0.522, CiteScore: 1)
Latinoamérica. Revista de estudios Latinoamericanos     Open Access   (Followers: 2)
Lecturas de Economía     Open Access  
Letras Históricas     Open Access   (Followers: 1)
Límite : Revista Interdisciplinaria de Filosofía y Psicología     Open Access  
Linguagem em (Dis)curso     Open Access  
Lingüística     Open Access   (SJR: 0.13, CiteScore: 0)
Lingüística y Literatura     Open Access   (Followers: 1)
Literatura y Lingüística     Open Access   (Followers: 1, SJR: 0.13, CiteScore: 0)
Lua Nova : Revista de Cultura e Política     Open Access   (SJR: 0.274, CiteScore: 0)
Luna Azul     Open Access  
Machado de Assis em Linha     Open Access   (SJR: 0.101, CiteScore: 0)
Madera y Bosques     Open Access   (Followers: 1)

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Infectio
Journal Prestige (SJR): 0.133
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0123-9392 - ISSN (Online) 2422-3794
Published by SciELO Homepage  [896 journals]
  • The new era of Integrase Strand Transfer Inhibitors

    •  
  • VIH disease, Integrase Strand Transfer Inhibitors and the future of elite
           controllers: bibliographic review

    • Abstract: Resumen: La Guía Colombiana de práctica clínica para la atención de la infección por VIH / Sida en adolescentes y adultos incluye como primera línea de tratamiento el uso de Inhibidores de integrasa; sin embargo, no incluye recomendaciones que soporten la decisión de tratar a los pacientes controladores elite (CE). La definición de controladores elite es confusa pues varía de un estudio a otro y se desconoce si las recomendaciones de tratamiento, se pueden aplicar a los controladores de forma similar; tampoco existen mecanismos apropiados para el seguimiento sistemático de los controladores elite cuando se inicia en ellos una terapia antirretroviral. Este artículo es una revisión bibliográfica de la información disponible sobre la definición de los pacientes controladores, y los controladores elite, su evolución clinica e inmunológica, el tratamiento y las terapias disponibles en Colombia.Abstract: The Colombian Guide to Clinical Practice for HIV / AIDS Care in Adolescents and Adults, includes as first line of treatment the use of integrase inhibitors; however, there is no information to support the decision to treat elite control patients (EC). The definition of elite controller is confusing, because of the changes in definitions between studies, and it is unknown whether these recommendations apply to these patients in a similar way; and how should be systematic follow-up of elite controllers when antiretroviral therapy is initiated. Present paper is a bibliographic review of the available information on the definition of the controllers, and elite controllers its clinical and immunological evolution, the treatment and therapies available in Colombia.
       
  • Evaluation and management of cardiovascualr risk in VIH infection: Expert
           consensus of ACIN (Colombian Association of Infectious Diseases)

    • Abstract: Resumen: Los pacientes con infección por VIH tienen una mayor incidencia de eventos cardiovasculares en comparación con la población general; los factores que contribuyen al incremento del riesgo de eventos cardiovasculares son la prevalencia de factores de riesgo cardiovascular tradicionales (FRCV), la infección por VIH que condiciona tanto un proceso de inflamación crónica como alteración de la función endotelial y la exposición a los antirretrovirales. Los factores que deben ser objeto de intervención son los FRCV tradicionales, en especial la alta tasa de fumadores entre este grupo de pacientes, la tamización y tratamiento de HTA, el síndrome metabólico y el acceso temprano a la terapia antirretroviral con medicamentos con mayor perfil de seguridad . Esta guía pretende proveer información y recomendaciones en el ámbito nacional acerca de la relación entre la infección por VIH/SIDA (Síndrome de Inmunodeficiencia Adquirida), uso de antirretrovirales y riesgo cardiovascular.Abstract: Patients with VIH infection have greater risk for cardiovascular diseases compared to general population. Risk factors that increase the frequency of cardiovascular events are: presence of cardiovascular traditional risk factors, chronic inflammation by HIV that impairs endothelial function and the exposure to antiretrovirals. The factors that should be the target for intervention are the traditional know cardiovascular factors such, especially high rate of smokers, screening and treatment for hypertension, metabolic syndrome and early access to HAART. The present guidelines provides information about the use of antiretrovirals in patients with HIV and its relation with cardiovascular risk.
       
  • Comorbidities among adults living with hiv from two healthcare centers in
           Colombia

    • Abstract: Abstract Objective: To determine the prevalence of comorbidities among adults living with HIV from two healthcare centers in Colombia, and to identify factors associated with comorbidity-free years. Methods: Observational, retrospective medical chart review study. Summary statistics for demographic and clinical characteristics were developed and relationship between comorbidity-free years were analyzed through Kaplan-Meier analysis and Cox regression. Results: 669 clinical charts were included, 71.7% were male and 16.1% were 50 years or older, 69.96% had at least one comorbidity. The most frequent comorbidities were dislipidemia(15.06%), hypertension(5.67%), risk factors were tobacco use(15.33%), alcohol intake(24.36%) and drugs abuse (14.66%). Discussion: These findings are consistent with previous reports showing the underlying processes of patients, producing multiple comorbidities. Conclusions: Significant proportion of patients have comorbidities that may increase risk of other complications or reduced comorbidity-free years. Poly-pharmacy among HIV+ adults need to be addressed to ensure adherence and minimize drug-drug interactions.Resumen Objetivo: Determinar la prevalencia de comorbilidades entre adultos viviendo con VIH en dos centros de atención en Colombia e identificar los factores asociados con años libres de comorbilidad . Metodos: Revisión observacional retrospectiva de historias clínicas. Resumen de estadísticas de características demográficas y clínicas y análisis de correlación entre características clínicas a través de pruebas de Kaplan-Meier y regresión de Cox. Resultados: Se analizaron 669 historias clínicas, 71.7% fueron hombres y 16.1% tuvieron 50 años o más, 69.96% tuvieron al menos una comorbilidad. Las comorbilidades más frecuentes fueron dislipidemia(15.06%), hipertensión (5.67%), los factores de riesgo fueron el uso de tabaco (15.33%), ingesta de alcohol (24.36%) y abuso de drogas (14.66%). Discusión: Estos hallazgos son consistentes con reportes previos que evidencian los procesos subyacentes que llevan a múltiples comorbilidades. Conclusiones: Una proporción significativa de pacientes tiene comorbilidades que pueden aumentar el riesgo de otras condiciones o los años libres de comorbilidad. La polifarmacia en pacientes HIV+ debe hacerse de manera que se asegure la adherencia y se minimicen las interacciones entre medicamentos.
       
  • Identification of mutations associated with resistance to Integrase Strand
           Transfer Inhibitors (INSTI) in ART-naïve HIV- 1 patients in Medellin,
           Colombia

    • Abstract: Resumen Objetivo: Estimar las frecuencias de mutaciones y de polimorfismos adicionales asociados con resistencia a los fármacos inhibidores de la integrasa del virus de inmunodeficiencia humana tipo 1 (VIH-1). Metodología: Estudio descriptivo, de corte transversal, en individuos VIH-1 positivos de la ciudad de Medellín, quienes no habían recibido tratamiento antirretroviral. En ellos se determinó, a través del método de 2-dideoxinucleótidos y el sistema ABI3730XL, la secuencia del gen de la integrasa del VIH-1 a partir del ARN viral circulante, la cual fue analizada en la base de datos de resistencia a medicamentos antirretrovirales de la Universidad de Stanford y según reportes de literatura científica. Resultados: Se encontraron las siguientes mutaciones (con sus respectivas frecuencias): una mutación mayor, E138K (1/46), tres mutaciones accesorias G163E (3/46), L74I (3/50) y E157Q (2/48), una mutación no polimórfica A128T (1/49) y otras dos mutaciones potencialmente asociadas con resistencia a inhibidores de integrasa S230N (9/39) y S119P/R/T (4/47, 2/47 y 14/47, respectivamente). Conclusiones: En las secuencias analizadas, llama la atención la presencia de al menos una mutación asociada a resistencia a inhibidores de integrasa en el 14% de los individuos estudiados, sugiriendo una pobre presión selectiva de este tipo de fármacos en la población viral circulante en la zona.Abstract Aim: To estimate the frequencies of major and accessory mutations, as well as additional polymorphisms associated with resistance to human immunodeficiency virus type 1 (VIH-1) integrase strand transfer inhibitors. Materials and methods: Descriptive cross-sectional study, focused on HIV-1 positive individuals from Medellín, recruited between 2013 and 2015, and that had not received antiretroviral therapy. In these patients, the sequence from HIV-1 integrase was determined from circulating viral RNA through Sanger chain termination method with the ABI3730XL system, and the sequences were analyzed using the HIV Drug Resistance Database from the University of Stanford, together with previous literature reports. Results: The following mutations associated with resistance to integrase strand transfer inhibitors, along with its respective frequencies, were found: one major mutation, E138K (1/46), three accessory mutations, G163E (3/46), L74I (3/50) and E157Q (2/48); one non-polymorphic mutation, A128T (1/49); and two mutations potentially associated with resistance to integrase strand transfer inhibitors, S230N (9/39) and S119P/R/T (4/47, 2/47 and 14/47, respectively). Conclusions: In the sequences analyzed, it is noteworthy the presence of at least one mutation related with resistance to integrase inhibitors in 14% of the studied patients, suggesting a poor selective pressure of this kind of drugs in the circulating viral population in our region.
       
  • Integrase Strand Transfer Inhibitors: Bases for its use in the clinical
           practice

    • Abstract: Resumen Los inhibidores de transferencia de la cadena de integrasa (INSTI) son medicamentos cuyo mecanismo de acción consiste en bloquear el proceso de integración del ADN proviral al ADN del hospedero mediante la unión al sitio catalítico de la integrasa viral y de esta manera evitar su replicación. Actualmente se cuenta con la aprobación INSTI de primera y segunda generación, presentan similitud en su mecanismo de acción, cambios en su estructura que modifican su barrera genética, pero mantienen su perfil de seguridad y efectividad. Desde su aprobación en el año 2007, se han llevado a cabo múltiples estudios clínicos cuyos resultados han permitido avanzar en el conocimiento de su efectividad en diferentes escenarios clínicos; (pacientes naive, experimentados, esquemas de simplificación y profilaxis, así, como en el conocimiento de su perfil de mutaciones de resistencia). En el presente artículo se hizo una revisión de los miembros de esta familia de antirretrovirales (ARV).Abstract: Integrase strand transfer inhibitors (INSTI) are drugs whose mechanism of action consists of blocking the integration process of the proviral DNA to the host DNA by binding to the catalytic site of the viral integration and thus preventing its replication. Currently it has the approval of INSTI of first generation, two of second generation and in process of approval of a third of second generation. The two generations has similitude in its mechanisms of action, changes in its structures that modify its genetic barrier, but keeping his security and effectiveness profile. Since the approval of INSTI´s in 2007 to date, multiple clinical studies have been carried out, whose results have allowed us to advance in the knowledge of their effectiveness in different clinical scenarios; (naive patients, experienced patients, simplification and prophylaxis schemes, as well as in the knowledge of their profile of resistance mutations). In the present article, we made a review of the members of this family of antiretrovirals (ARV).
       
 
JournalTOCs
School of Mathematical and Computer Sciences
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