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Publisher: SciELO   (Total: 737 journals)

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Showing 601 - 741 of 741 Journals sorted alphabetically
Revista Estudos Feministas     Open Access   (SJR: 0.208, CiteScore: 0)
Revista Facultad de Ciencias Económicas: Investigación y Reflexión     Open Access  
Revista Facultad de Ingenieria - Universidad de Tarapaca     Open Access   (Followers: 1)
Revista Facultad de Ingeniería Universidad de Antioquia     Open Access   (Followers: 1, SJR: 0.172, CiteScore: 0)
Revista Facultad de Medicina de la Universidad Nacional de Colombia     Open Access   (SJR: 0.125, CiteScore: 0)
Revista Facultad Nacional de Agronomía, Medellín     Open Access   (SJR: 0.138, CiteScore: 0)
Revista Facultad Nacional de Salud Pública     Open Access  
Revista Gaúcha de Enfermagem     Open Access   (SJR: 0.225, CiteScore: 1)
Revista Geológica de América Central     Open Access  
Revista Geológica de Chile     Open Access   (Followers: 1)
Revista Gerencia y Políticas de Salud     Open Access   (SJR: 0.136, CiteScore: 0)
Revista Habanera de Ciencias Médicas     Open Access   (SJR: 0.211, CiteScore: 0)
Revista Historia y Sociedad     Open Access  
Revista IBRACON de Estruturas e Materiais     Open Access   (Followers: 1)
Revista Ingenieria de Construcción     Open Access   (Followers: 1, SJR: 0.204, CiteScore: 0)
Revista Ingenierías Universidad de Medellín     Open Access  
Revista Integra Educativa     Open Access  
Revista Interamericana de Bibliotecología     Open Access   (Followers: 7)
Revista Internacional de Contaminación Ambiental     Open Access   (SJR: 0.152, CiteScore: 0)
Revista ION     Open Access  
Revista IUS     Open Access  
Revista Katálysis     Open Access  
Revista Lasallista de Investigación     Open Access   (SJR: 0.146, CiteScore: 0)
Revista Latino-Americana de Enfermagem     Open Access   (SJR: 0.339, CiteScore: 1)
Revista Latinoamericana de Bioética     Open Access  
Revista Latinoamericana de Desarrollo Económico     Open Access  
Revista Latinoamericana de Filosofía     Open Access   (Followers: 1)
Revista Latinoamericana de Investigación en Matemática Educativa     Open Access   (SJR: 0.171, CiteScore: 0)
Revista Latinoamericana de Psicopatologia Fundamental     Open Access   (SJR: 0.201, CiteScore: 0)
Revista Medica de Chile     Open Access   (SJR: 0.259, CiteScore: 1)
Revista Médica del Hospital Nacional de Niños Dr. Carlos Sáenz Herrera     Open Access   (Followers: 1)
Revista Médica Electrónica     Open Access  
Revista Médica La Paz     Open Access  
Revista Mexicana de Análisis de la Conducta     Open Access   (SJR: 0.405, CiteScore: 1)
Revista Mexicana de Astronomía y Astrofísica     Open Access   (Followers: 2, SJR: 0.596, CiteScore: 1)
Revista Mexicana de Biodiversidad     Open Access   (SJR: 0.421, CiteScore: 1)
Revista Mexicana de Ciencias Agrícolas     Open Access   (Followers: 1)
Revista Mexicana de Ciencias Geológicas     Open Access   (SJR: 0.308, CiteScore: 1)
Revista Mexicana de Ciencias Pecuarias     Open Access   (Followers: 1, SJR: 0.17, CiteScore: 0)
Revista Mexicana de Economía y Finanzas     Open Access  
Revista Mexicana de Física     Open Access   (SJR: 0.203, CiteScore: 0)
Revista mexicana de física E     Open Access  
Revista Mexicana de Fitopatología     Open Access  
Revista Mexicana de Ingeniería Química     Open Access   (SJR: 0.328, CiteScore: 1)
Revista Mexicana de Investigación Educativa     Open Access   (Followers: 3, SJR: 0.291, CiteScore: 0)
Revista Mexicana de Micologí­a     Open Access  
Revista Mexicana de Sociologí­a     Open Access   (Followers: 9, SJR: 0.142, CiteScore: 0)
Revista Musical Chilena     Open Access   (SJR: 0.1, CiteScore: 0)
Revista MVZ Córdoba     Open Access   (SJR: 0.173, CiteScore: 0)
Revista Odonto Ciência     Open Access   (SJR: 0.101, CiteScore: 0)
Revista Opinión Jurídica     Open Access  
Revista Panamericana de Salud Pública     Open Access   (SJR: 0.452, CiteScore: 1)
Revista Paulista de Pediatria     Open Access   (SJR: 0.472, CiteScore: 1)
Revista Perspectivas     Open Access  
Revista Pilquen : Sección Ciencias Sociales     Open Access  
Revista Portuguesa de Cirurgia     Open Access   (Followers: 1)
Revista Portuguesa de Enfermagem de Saúde Mental     Open Access  
Revista Portuguesa de Imunoalergologia     Open Access   (Followers: 2, SJR: 0.141, CiteScore: 0)
Revista Portuguesa de Ortopedia e Traumatologia     Open Access  
Revista Portuguesa de Saúde Pública     Open Access   (SJR: 0.155, CiteScore: 0)
Revista Portuguesa e Brasileira de Gestão     Open Access  
Revista Signos     Open Access   (SJR: 0.174, CiteScore: 0)
Revista Universitaria de Geografía     Open Access  
Revista Uruguaya de Cardiologia     Open Access  
Revista Veterinaria     Open Access   (SJR: 0.105, CiteScore: 0)
RGO : Revista Gaúcha de Odontologia     Open Access   (SJR: 0.104, CiteScore: 0)
RISTI : Revista Ibérica de Sistemas e Tecnologias de Informação     Open Access   (SJR: 0.213, CiteScore: 1)
RLA : revista de linguistica teorica y aplicada     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Rodriguésia     Open Access   (SJR: 0.734, CiteScore: 2)
SA Orthopaedic J.     Open Access   (Followers: 2)
Salud Colectiva     Open Access   (SJR: 0.22, CiteScore: 0)
Salud Mental     Open Access   (Followers: 1, SJR: 0.173, CiteScore: 1)
Sanidad Militar     Open Access  
São Paulo em Perspectiva     Open Access  
Sao Paulo Medical J.     Open Access   (SJR: 0.334, CiteScore: 1)
Saúde e Sociedade     Open Access   (SJR: 0.384, CiteScore: 0)
Saúde em Debate     Open Access  
Sba: Controle & Automação Sociedade Brasileira de Automatica     Open Access  
Scientia Agricola     Open Access   (SJR: 0.578, CiteScore: 2)
Scientiae Studia     Open Access  
Secuencia     Open Access   (SJR: 0.101, CiteScore: 0)
Serviço Social & Sociedade     Open Access   (Followers: 1)
Sexualidad, Salud y Sociedad (Rio de Janeiro)     Open Access   (Followers: 2)
Si Somos Americanos     Open Access  
Signos Filosóficos     Open Access   (SJR: 0.107, CiteScore: 0)
Silva Lusitana     Open Access  
Sociedade & Natureza     Open Access  
Sociedade e Estado     Open Access   (Followers: 2, SJR: 0.127, CiteScore: 0)
Sociologia : Revista da Faculdade de Letras da Universidade do Porto     Open Access  
Sociologias     Open Access   (Followers: 2, SJR: 0.15, CiteScore: 0)
Sociológica     Open Access   (Followers: 2)
Soldagem & Inspeção     Open Access   (SJR: 0.238, CiteScore: 0)
South African Dental J.     Open Access  
South African J. of Agricultural Extension     Open Access   (Followers: 4)
South African J. of Animal Science     Open Access   (Followers: 3, SJR: 0.387, CiteScore: 1)
South African J. of Childhood Education     Open Access   (Followers: 1)
South African J. of Enology and Viticulture     Open Access   (SJR: 0.301, CiteScore: 1)
South African J. of Industrial Engineering     Open Access   (Followers: 3, SJR: 0.201, CiteScore: 1)
South African J. of Occupational Therapy     Open Access   (Followers: 39)
South African J. of Surgery     Open Access   (Followers: 1, SJR: 0.162, CiteScore: 0)
South African Medical J.     Open Access   (Followers: 5, SJR: 0.45, CiteScore: 1)
Studia Historiae Ecclesiasticae     Open Access   (Followers: 3)
Summa Phytopathologica     Open Access   (SJR: 0.258, CiteScore: 0)
Tecnología Química     Open Access  
Tecnología y Ciencias del Agua     Open Access   (SJR: 0.153, CiteScore: 0)
Temas y Debates     Open Access  
Tempo     Open Access   (Followers: 2, SJR: 0.103, CiteScore: 0)
Tempo Social     Open Access   (Followers: 2, SJR: 0.135, CiteScore: 0)
Teología y Vida     Open Access   (Followers: 1, SJR: 0.122, CiteScore: 0)
Terapia Psicológica     Open Access   (SJR: 0.394, CiteScore: 1)
Texto & Contexto - Enfermagem     Open Access   (SJR: 0.273, CiteScore: 1)
The European J. of Psychiatry (edicion en español)     Open Access   (Followers: 1)
Theologica Xaveriana     Open Access   (SJR: 0.14, CiteScore: 0)
Tinkazos     Open Access  
Tópicos del seminario     Open Access   (Followers: 1)
Toxicodependências     Open Access  
Trabalho, Educação e Saúde     Open Access  
Trabalhos em Linguistica Aplicada     Open Access  
Trans/Form/Ação - Revista de Filosofia     Open Access   (SJR: 0.1, CiteScore: 0)
Transinformação     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Trends in Psychiatry and Psychotherapy     Open Access   (Followers: 9, SJR: 0.323, CiteScore: 1)
Tydskrif vir Geesteswetenskappe     Open Access   (SJR: 0.193, CiteScore: 0)
Tydskrif vir Letterkunde     Open Access   (SJR: 0.235, CiteScore: 0)
Ultima Década     Open Access  
Universidad y Ciencia     Open Access   (Followers: 1)
Universitas Medica     Open Access   (Followers: 1)
Universitas Philosophica     Open Access  
Universitas Scientiarum     Open Access   (SJR: 0.192, CiteScore: 1)
Universum : Revista de Humanidades y Ciencias Sociales     Open Access   (Followers: 1, SJR: 0.155, CiteScore: 0)
Vaccimonitor     Open Access   (Followers: 1, SJR: 0.177, CiteScore: 0)
Varia Historia     Open Access   (SJR: 0.152, CiteScore: 0)
Veritas : Revista de Filosofí­a y Teología     Open Access   (Followers: 1, SJR: 0.101, CiteScore: 0)
Veterinaria (Montevideo)     Open Access  
Veterinaria México     Open Access  
Vibrant : Virtual Brazilian Anthropology     Open Access  
Visión de futuro     Open Access  
Vniversitas     Open Access   (SJR: 0.16, CiteScore: 0)
Water SA     Open Access   (Followers: 2, SJR: 0.361, CiteScore: 1)
West Indian Medical J.     Open Access   (Followers: 1, SJR: 0.174, CiteScore: 0)
Yesterday and Today     Open Access   (Followers: 1)
Zoologia (Curitiba)     Open Access  

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Revista Medica de Chile
Journal Prestige (SJR): 0.259
Citation Impact (citeScore): 1
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Online) 0034-9887
Published by SciELO Homepage  [737 journals]
  • Quality control: an essential requirement in today's practice of medicine

    •  
  • Liver transplantation: development, learning curve and results after the
           first 300 cases

    • Abstract: Background: Liver transplantation (LT) is an option for people with liver failure who cannot be cured with other therapies and for some people with liver cancer. Aim: To describe, and analyze the first 300 LT clinical results, and to establish our learning curve. Material and Methods: Retrospective cohort study with data obtained from a prospectively collected LT Program database. We included all LT performed at a single center from March 1994 to September 2017. The database gathered demographics, diagnosis, indications for LT, surgical aspects and postoperative courses. We constructed a cumulative summation test for learning curve (LC-CUSUM) using 30-day post-LT mortality. Mortality at 30 days, and actuarial 1-, and 5-year survival rate were analyzed. Results: A total of 281 patients aged 54 (0-71) years (129 women) underwent 300 LT. Ten percent of patients were younger than 18 years old. The first, second and third indications for LT were non-alcoholic steatohepatitis, chronic autoimmune hepatitis and alcoholic liver cirrhosis, respectively. Acute liver failure was the LT indication in 51 cases (17%). The overall complication rate was 71%. Infectious and biliary complications were the most common of them (47 and 31% respectively). The LC-CUSUM curve shows that the first 30 patients corresponded to the learning curve. The peri-operative mortality was 8%. Actuarial 1 and 5-year survival rates were 82 and 71.4%, respectively. Conclusions: Outcome improvement of a LT program depends on the accumulation of experience after the first 30 transplants and the peri-operative mortality directly impacted long-term survival.
       
  • Association of the TCF7L2 (RS7903146) genotype with adiposity and
           metabolic markers in the Chilean adult population

    • Abstract: Background: Type 2 diabetes etiology has a strong genetic component. More than 20 genetic variants have been associated with diabetes and other metabolic markers. However, the polymorphism rs7903146 of the TCF7L2 gene has shown the strongest association. Aim: To investigate the association of TCF7L2 (rs7903146) genotype with adiposity and metabolic markers in the Chilean adult population. Material and Methods: The association of TCF7L2 (rs7093146) with adiposity and metabolic markers was studied in 301 participants. The outcomes of the study were adiposity markers (body weight, body mass index (BMI), fat mass and waist circumference) and metabolic markers (blood glucose, insulin, HOMA-IR, lipid profile, high sensitivity C-reactive protein (CRP), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT) and leptin). Results: There was an association between the polymorphism TCF7L2 genotype and fasting blood glucose. The latter increased by 4.86 mg/dl per each copy of the risk allele [(95% confidence intervals (CI): 0.48; 9.24), p = 0.03] in the unadjusted adjusted model. However, this association was slightly attenuated in the fully adjusted model [4.38 mg/dl (95% IC: 0.16; 8.60), p = 0.04)]. There were no associations between the TCF7L2 genotype and any other metabolic or adiposity outcome. Conclusions: These findings confirm the association between the TCF7L2 (rs7903146) and fasting glucose in the Chilean population. However, further studies are needed to confirm the association between the TCF7L2 and diabetes risk in the Chilean population.
       
  • Effectiveness and tolerability of low volume bowel cleansing polyethylene
           glycol solution for colonoscopy

    • Abstract: Background: A successful colonoscopy depends, among other factors, on a proper colon cleansing. This variable also affects the acceptance of the patient to carry out the study. Aim: To analyze the efficacy and tolerability of a low volume polyethylene glycol formulation (2 liters), compared to the conventional presentation of 4 liters. Material and Methods: Patients referred for a colonoscopy were randomly divided to receive either two or four liter of polyethylene glycol as bowel cleansing, which was assessed using the Boston score. Raters of the latter were blinded to the volume of polyethylene glycol that the patients used. Results: Seventy-four patients participated in the study. Subjects who received a 4 liters preparation had an average Boston score of 7.78, versus 8.16 for patients who received a volume of 2 liters (p = 0.267). No significant differences in tolerability were observed between both groups. No significant differences in the efficacy and tolerability between a conventional or a reduced volume of polyethylene glycol solution for the preparation of a colonoscopy were observed. These findings may be especially important for subgroups of patients with difficulties for oral administration of fluids.
       
  • Immunocompetent adults hospitalized for a community-acquired pneumonia:
           Serum C-reactive protein as a prognostic marker

    • Abstract: Background: C-reactive protein (CRP) is used to monitor patients’ response during treatment of infectious diseases. Morbidity and mortality associated with community-acquired pneumonia (CAP) is high, particularly in hospitalized patients. Better risk prediction during hospitalization could improve management and ultimately reduce mortality rates. Aim: To evaluate CRP measured at admission and the third day of hospitalization as a predictor for adverse events in CAP. Material and Methods: A prospective cohort study of adult patients hospitalized with CAP at an academic hospital. Major adverse outcomes were admission to ICU, mechanical ventilation, prolonged hospital length of stay, hospital complications and 30-day mortality. Predictive associations between CRP (as absolute levels and relative decline at third day) and adverse events were analyzed. Results: Eight hundred and twenty-three patients were assessed, 19% were admitted to ICU and 10.6% required mechanical ventilation. The average hospital stay was 8.8 ± 8.2 days, 42% had nosocomial complications and 8.1% died within 30 days. Ninety eight percent of patients had elevated serum CRP on admission to the hospital (18.1 ± 14.1 mg/dL). C-reactive protein measured at admission was associated with the risk of bacterial pneumonia, bacteremic pneumonia, septic shock and use of mechanical ventilation. Lack of CRP decline within three days of hospitalization was associated with high risk of complications, septic shock, mechanical ventilation and prolonged hospital stay. Conclusions: CRP responses at third day of hospital admission was a valuable predictor of adverse events in hospitalized CAP adult patients.
       
  • Stereotactic body radiation therapy (SBRT) for pain management in spine
           bone metastases

    • Abstract: Background: Treatment of spine bone metastases with stereotactic radio-therapy (SBRT) may produce greater pain relief than palliative radiotherapy. Aim: To evaluate the analgesic response to SBRT. Material and Methods: A search was made in an electronic database of all patients treated by SBRT in our center. We found 20 patients that were treated with SBRT in the spine on 24 sites (lesions). Analgesic response was evaluated at 3 and 6 months after SBRT. Other factors such as age, sex, functional status, diagnosis, metastasis location, dosimetry and toxicity of the treatment were also described. Results: The median follow-up was 8.1 months. Complete pain relief occurred at three months in 74% of the treated sites. At three months, 78% of the patients presented a functional status 0 (ECOG). The median dose used was 24 Gy in 2 fractions. No cases of G3 or greater toxicity were recorded. Conclusions: The analgesic response to SBRT seems to be better than that reported for palliative radiotherapy.
       
  • Prevalence of pain among patients admitted to a clinical hospital

    • Abstract: Background: Pain prevalence during hospital admission is variable, with estimates ranging from 32 to 77%. Aim: To determine pain prevalence during admission to a clinical hospital. Material and Methods: Patients admitted to medical and surgical wards were interrogated about the presence of pain within 48 to 72 hours after admission. Subjective pain was analyzed using a scale ranging from 0 to 10. Data was analyzed separately for medical, surgical, and obstetrical patients. Results: A total of 736 patients aged 18 to 94 years (416 women) were recruited. Pain prevalence at 48 hours after admission was 56% (95% confidence intervals (CI (52.7 to 60.1). Pain prevalence in medical, surgical and obstetric patients was 37% (95% CI 31.4 to 42.1), 70% (95% CI 64.5 to 75.5) and 77% (95% CI 68.6 to 84), respectively. The median pain intensities in medical, surgical, and obstetrical patients were 7 (interquartile range (IQR) 6-8), 7 (IQR 5-8) y 7 (IQR 5-8), respectively. Conclusions: The prevalence of pain among patients admitted to the hospital is high, especially in obstetric and surgical units.
       
  • Depression and geriatric assessment in older people admitted for hip
           fracture

    • Abstract: ABSTRACT Background: Depression is common among older people with hip fracture. Aim: To assess depression scores and other mental and physical health variables in older people with and without depression, admitted to a traumatology ward for a hip fracture. Material and Methods: Cross sectional study of older patients admitted for surgical treatment of hip fracture. Demographic, clinical and laboratory variables were recorded. Twelve surveys were applied to assess general wellbeing, mental health, fall risk, nutritional status, basic and instrumental activities of daily living, social resources and depression (using Yesavage Depression Scale). Results: We assessed 310 patients aged 78 (72-83) years, 72% women. Overall depression prevalence was 46% and its frequency was significantly higher in women, people over 81 years of age, diabetics and subjects with anxiety. The Yesavage score in patients with and without depression was 6.5 and 3, respectively. The median number of medications used by patients with and without depression was 3 and 2 (p < 0.01). Conclusions: There is a high frequency of depression in these patients, especially in women and subjects older than 81 years of age. Routine geriatric assessments should be performed in hospitalized older patients with hip fracture. Antecedentes: La alta prevalencia de depresión en la población anciana con fractura de cadera rara vez se reconoce. Objetivo: Estimar la prevalencia de depresión y comparar la salud física, mental, y otras variables geriátricas, en ancianos hospitalizados por fractura de cadera con y sin depresión. Material y Métodos: Estudio transversal con muestreo probabilístico con reemplazo, de pacientes que ingresaron para su atención quirúrgica. Se recolectaron variables sociodemográficas, antropométricas, clínicas y de laboratorio. Se aplicaron 12 encuestas para evaluar el estado de salud general, mental, riesgo de caídas, estado nutricional, actividades básicas e instrumentadas de la vida diaria, recursos sociales y depresión, entre otras. Para detectar depresión se usó la escala de tamizaje de Depresión Geriátrica Yesavage (EDG-15). Resultados: Se revisaron 310 pacientes (grupos con y sin depresión). La prevalencia de depresión fue de 46%, significativamente mayor en mujeres, sujetos mayores de 81 años, diabéticos y aquellos con ansiedad. La mediana de la puntuación EDG-15 fue de 6,5 y 3 para sujetos con y sin depresión (n = 142), (n = 168), respectivamente. La mediana del número de fármacos fue de 3 y 2 en estos grupos (p < 0,01). Conclusiones: La evaluación geriátrica sistemática en la atención del adulto mayor con fractura de cadera es indispensable, lo que podría aumentar las tasas de detección de depresión y de otros padecimientos e impactar positivamente en la calidad de vida y restauración de la función.
       
  • Factors associated with cognitive impairment in older adults in Chile

    • Abstract: Background: The risk factors for the development of cognitive impairment are not well known. Aim: To identify socio-demographic, lifestyle and health-related factors associated with cognitive impairment in older Chilean adults. Material and Methods: Data analysis of 1,384 participants ≥ 60 years who participated in the National Health Survey of Chile 2009-2010. Sociodemographic, lifestyle and health-related factors were used as exposure variables of interest. Cognitive impairment was assessed using an abbreviated version of the Mini Mental test and defined as a score < 13 points of a maximum of 19. A logistic regression was used to identify factors associated with cognitive impairment. Results: In this sample, the prevalence of cognitive impairment was 11.6 [95% confidence intervals (CI): 8.8; 15.2]. The factors associated with cognitive impairment were age (Odds ratio (OR) for > 76 years: 4.89, p < 0.01), male sex (OR: 2.42, p = 0.02), lower education (OR: 21.6, p < 0.01), physical inactivity (OR: 2.07, p = 0.02), sedentary behavior (OR: 2.23, p = 0.01), sleeping > 9/hours/day (OR: 2.98, p = 0.01), consumption of < 5 portions/day of fruit and vegetables (OR: 2.02, p = 0.05), having an unhealthy lifestyle (OR: 6.10, p = 0.0001), being underweight (OR: 3.67, p < 0.01), obesity (OR: 3.32, p = 0.03), having hearing impairment (OR: 2.26, p = 0.02), having a visual impairment (OR: 3.89, p < 0.01), a history of depression (OR: 3.03, p = 0.01) and having a physical disability (OR: 5.63, p < 0.01). Conclusions: We identified 14 factors associated with cognitive impairment. Although some of these factors were non-modifiable such as age and sex, most of them could be modified by implementing prevention programs aiming to improve lifestyle behaviors in older adults in Chile.
       
  • The effect of an educational intervention on the metabolic control of
           diabetic patients

    • Abstract: Background: Diabetic patients have a poor adherence to lifestyle changes and a low compliance with medications. Aim: To study the effect of an educational intervention on the metabolic control of patients with diabetes mellitus. Patients and Methods: We studied insulin requiring diabetic patients attended at a primary health care clinic, who were randomly divided in two groups. One group participated in four modules of an educative intervention, carried out in four occasions. The other group did not participate in the educational sessions. Clinical, anthropometric and laboratory variables of the participants were obtained from their medical records, at three and six months after the intervention. Results: We recruited 22 men aged 64 ± 14 years and 48 women aged 63 ± 10 years. Thirty-six of these received the educational intervention. Eighty four percent were overweight or obese. The proportion of compensated patients, defined as those having a glycosylated hemoglobin between 7 and 9%, increased significantly after the educational intervention (χ2 = 7.9 p < 0.01, odds ratio: 0.2). Conclusions: A educational intervention in patients with insulin requiring diabetes mellitus improved the metabolic control of their disease.
       
  • Exception to informed consent in research: when is this possible in
           Chile'

    • Abstract: Exceptions or waivers to informed consent in research in Chile are an ethical issue that has not been addressed in all its complexity by the scientific community. The possible waivers to this process could make the difference for the feasibility, success or failure of a study. The purpose of this document is to clarify within the available information, what is the current situation about the exceptions to informed consent in research and what are the ethical-legal guidelines in Chile. Articles were reviewed in both English and Spanish from indexed journals and those documents that meet the inclusion criteria were selected. There is limited information available about waivers to informed consent, which indicates that the ethical guidelines are similar among countries that honor the Declaration of Helsinki, including Chile. However, the current Chilean legislation does not include exceptions. Ethics Committees that authorize research in line with international ethical guidelines could allow possible exceptions. Based on our findings, it is necessary to evaluate possible exceptions for informed consent for research performed in Chile, both from the legal point of view and based on the experience of scientists.
       
  • Paraproteins. A review

    • Abstract: Hematological neoplasms are tumors of cells in different states of maturation and differentiation. Since monoclonal gammopathies (MG) refer to B mature lymphocyte neoplasms, lymphogenesis should be well known. We must keep in mind that the last stage of maturation of these lymphocytes is the plasma cell. This is how a MG could appear in the context of a plasma cell neoplasm, such as multiple myeloma or amyloidosis, but also in relation to a lymphoma. A monoclonal peak is produced by mature B lymphocytes or plasma cells that secrete a monoclonal protein (Immunoglobulin), and represents a MG. But it must be emphasized that, in the correct clinical context, a hypogammaglobulinemia can represent a MG as well. Another important point is the understanding and interpretation of requested tests, such as protein electrophoresis (PEP), immunofixation (IFx) or serum free light chains (sFLC). The current MG screening panel includes these three studies (PEF, IFx, sFLC), although a simpler panel measuring PEF and sFLC has also been proposed, but not yet formally validated. Therefore, screening done only with PEP is insufficient.
       
  • Worsening situation of tuberculosis in Chile

    • Abstract: Background: Recent data suggest an increase in tuberculosis (TB) incidence in Chile. Aim: To evaluate recent epidemiological trends, geographic extension and potential factors associated with TB reemergence in Chile. Material and Methods: Data analysis from official sources and trend analysis. Results: TB incidence rate increased from 12.3 (2014) to 14.7 (2017) per 100,000 inhabitants. Morbidity rates also increased in nine out of 15 regions. The proportion of TB cases in specific groups has also increased in the last six years: HIV/AIDS (68%), immigrants (118%), drug users/alcoholics (267%) and homeless people (370%). Several indicators of the national TB program performance have deteriorated including TB case detection, HIV co-infection study and contact tracing activities. Overall results indicate a higher than expected case-fatality ratio (> 3%), high rates of loss from follow-up (> 5%), and low percentage of cohort healing rate (< 90%). This decline is associated with a Control Program with scarce human resources whose central budget decreased by 90% from 2008 to 2014. New molecular diagnostic tools and liquid media culture were only recently implemented. Conclusions: TB trends and overall program performance indicators have deteriorated in recent years in Chile and several factors appear to be involved. Multiple strategies will be required to rectify this situation.
       
  • The melancholy of the philosopher in the Intercenales (1424-1439)

    • Abstract: This essay analyzes the presence of the modern concept of melancholy in the Intercenales (1424-1439) by the humanist Leon Battista Alberti. The Intercenales is a collection of satirical, allegorical and moralizing writings composed with the purpose of entertaining an audience of close friends. In spite of the fact that the term "melancholia" does not appear in the text, this paper argues that Alberti's character of “the philosopher” is melancholic, since he is "ill in the soul" (suffering from morbus animi), and his illness is evidenced by a series of physical and psychological symptoms associated with melancholy in the classical and medieval medical traditions. These symptoms are stomach pain, pallor, insomnia, a rich memory, a propensity to study at night, and an ability to have premonitory dreams. With this characterization Alberti promotes a connection between melancholy and being a genius, which is distinctive to the Renaissance and the basis for the modern concept of melancholy. The essay concludes that the ultimate purpose of the Intercenales is to cure, from a literary and philosophical point of view, the illness of the melancholic philosopher.
       
  • Experience of continuing online education in gastroenterology for non
           specialist medical doctors

    • Abstract: Background: Continuing education is essential for health professions and online courses can be a good way for professional development. Aim: To describe the experience with online courses for continuing education in hepatology and gastroenterology and to analyze their educational impact. Material and Methods: A three years' experience in courses on liver diseases and digestive tract is described. Their curricular design, methodology, and the educational impact was analyzed using the four levels of the Kirkpatrick's model. Results: On average, there were 321 students per course (2015-2017). 94% were Chilean and 6% from abroad (20 countries). In the educational impact analysis, in level 1 “reaction”: 93% said that the course fulfilled their expectations and 92% would recommend it. In level 2 “learning”: 42% approved the courses. Level 3 “behavior” was not evaluated and level 4 “organizational change” highlighted that the traditional face-to-face continuing education model of Chilean Gastroenterology Society (SChG) changed to full distance model in these three courses, with 1284 students from South America, Asia and Europe, in a 3-years-period. Additionally, these programs were included in the Medical Society of Santiago (SMS) continuing education agenda. Conclusions: The alliance between the SMS and the SChG generated on line courses that meet the educational needs of physicians and medical students, with excellent results and student perception.
       
  • Conscientious objectors in Chilean medical education

    • Abstract: The Chilean Law regulating the voluntary interruption of pregnancy, contemplates the possibility that health personnel may refrain from doing the procedure if they have stated that they are conscientious objectors (CO). There are numerous articles on the subject. However, the impact on medical training centers when a student or resident abstain from performing certain clinical procedures invoking CO, has seldom been analyzed. In this article, we explore the rights and duties of the CO students to perform an abortion or other clinical procedures for either religious or cultural reasons. Based on international experience, we recommend that all health care centers should have established and publicly known policies on this matter. Finally, we honor CO invoked by students, based on three general principles. First, the autonomy and moral integrity of the students should be respected. Second, an adequate ethical sensitivity is promoted. Third, it contributes to the necessary heterogeneity and diversity of students, promoting a desirable pluralism. However, certain interests and values, such as the well-being of patients, must be considered over and above accepting the CO requests.
       
  • Lupus enteritis. Report of one case

    • Abstract: In lupus enteritis, circulating pathological immune complexes and thrombosis of intestinal vessels may occur, resulting in acute abdominal pain. We report a 24-year-old woman without a history of systemic lupus erythematosus (SLE), admitted for abdominal pain. An exploratory laparotomy found an appendicitis along with ascites. An appendectomy was performed, and the patient was discharged from the hospital two days later. Three days after discharge, the patient was admitted to another hospital due to the persistence of abdominal pain. An abdominal computed tomography scan showed diffuse mesenteric congestion, concentric bowel loops (double halo or target sign) and the presence of free fluid in the peritoneal cavity. Suspecting a rheumatic disorder, the diagnosis of SLE was confirmed by immunological studies. The patient was treated with pulses of methylprednisolone with good results.
       
  • Acute pancreatitis due to hypercalcemia during pregnancy. Report of one
           case

    • Abstract: Acute pancreatitis during pregnancy is uncommon and usually associated with gallstones. However other etiologies must be considered. We report a 24 years old woman with a 32 weeks pregnancy consulting for abdominal pain, nausea and vomiting. She had elevated lipase and amylase levels, a corrected serum calcium of 13.1 mg/dl and a serum phosphate of 1.6 mg/dl. A magnetic resonance colangiopancreatography showed an enlarged pancreas with inflammatory changes and a normal Wirsung duct. A parathyroid nodule was found on cervical ultrasonography. The patient was treated initially with cinacalcet with partial response. A parathyroidectomy was performed at 39 weeks of pregnancy with a good maternal and fetal evolution.
       
  • Handbook of Intensive Care Medicine

    • Abstract: Acute pancreatitis during pregnancy is uncommon and usually associated with gallstones. However other etiologies must be considered. We report a 24 years old woman with a 32 weeks pregnancy consulting for abdominal pain, nausea and vomiting. She had elevated lipase and amylase levels, a corrected serum calcium of 13.1 mg/dl and a serum phosphate of 1.6 mg/dl. A magnetic resonance colangiopancreatography showed an enlarged pancreas with inflammatory changes and a normal Wirsung duct. A parathyroid nodule was found on cervical ultrasonography. The patient was treated initially with cinacalcet with partial response. A parathyroidectomy was performed at 39 weeks of pregnancy with a good maternal and fetal evolution.
       
  • Associations of patients in Chile: Opportunities for participation

    • Abstract: Acute pancreatitis during pregnancy is uncommon and usually associated with gallstones. However other etiologies must be considered. We report a 24 years old woman with a 32 weeks pregnancy consulting for abdominal pain, nausea and vomiting. She had elevated lipase and amylase levels, a corrected serum calcium of 13.1 mg/dl and a serum phosphate of 1.6 mg/dl. A magnetic resonance colangiopancreatography showed an enlarged pancreas with inflammatory changes and a normal Wirsung duct. A parathyroid nodule was found on cervical ultrasonography. The patient was treated initially with cinacalcet with partial response. A parathyroidectomy was performed at 39 weeks of pregnancy with a good maternal and fetal evolution.
       
  • The Non-Communicable Diseases paradigm: a linguistic vision that creates
           realities

    • Abstract: Acute pancreatitis during pregnancy is uncommon and usually associated with gallstones. However other etiologies must be considered. We report a 24 years old woman with a 32 weeks pregnancy consulting for abdominal pain, nausea and vomiting. She had elevated lipase and amylase levels, a corrected serum calcium of 13.1 mg/dl and a serum phosphate of 1.6 mg/dl. A magnetic resonance colangiopancreatography showed an enlarged pancreas with inflammatory changes and a normal Wirsung duct. A parathyroid nodule was found on cervical ultrasonography. The patient was treated initially with cinacalcet with partial response. A parathyroidectomy was performed at 39 weeks of pregnancy with a good maternal and fetal evolution.
       
 
 
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