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Showing 201 - 400 of 911 Journals sorted alphabetically
Cuadernos de Administración (Universidad del Valle)     Open Access   (Followers: 3)
Cuadernos de Contabilidad     Open Access   (Followers: 3)
Cuadernos de Desarrollo Rural     Open Access   (Followers: 1, SJR: 0.154, CiteScore: 0)
Cuadernos de Economía     Open Access   (Followers: 1, SJR: 0.115, CiteScore: 0)
Cuadernos de Economía     Open Access   (Followers: 3)
Cuadernos de Economia - Latin American J. of Economics     Open Access   (Followers: 4)
Cuadernos de Historia     Open Access   (Followers: 2)
Cuadernos de Historia de la Salud Publica     Open Access  
Cuadernos de Medicina Forense     Open Access   (Followers: 2, SJR: 0.1, CiteScore: 0)
Cuadernos de Psicologia del Deporte     Open Access   (SJR: 0.423, CiteScore: 1)
Cuadernos del CENDES     Open Access   (SJR: 0.109, CiteScore: 0)
Cuadernos.info     Open Access   (SJR: 0.38, CiteScore: 0)
Cubo. A Mathematical J.     Open Access  
Cuestiones Constitucionales     Open Access   (Followers: 2, SJR: 0.1, CiteScore: 0)
Cuicuilco     Open Access   (Followers: 1)
Cuicuilco. Revista de Ciencias Antropológicas     Open Access   (Followers: 1)
Cultivos Tropicales     Open Access   (Followers: 1)
Cultura y Representaciones Sociales     Open Access   (Followers: 1)
Culturales     Open Access   (Followers: 3)
Dados - Revista de Ciências Sociais     Open Access   (SJR: 0.37, CiteScore: 0)
De Jure     Open Access   (Followers: 1)
DELTA : Documentação de Estudos em Lingüística Teórica e Aplicada     Open Access   (SJR: 0.133, CiteScore: 0)
Dementia & Neuropsychologia     Open Access   (Followers: 11, SJR: 0.205, CiteScore: 0)
Dental Press J. of Orthodontics     Open Access   (Followers: 5, SJR: 0.489, CiteScore: 1)
Desacatos     Open Access   (Followers: 1)
Desacatos : Revista de Antropología Social     Open Access   (Followers: 1)
Desarrollo y Sociedad     Open Access   (Followers: 3, SJR: 0.109, CiteScore: 0)
Diálogo Andino - Revista de Historia, Geografía y Cultura Andina     Open Access   (Followers: 1, SJR: 0.116, CiteScore: 0)
Diánoia     Open Access   (Followers: 1)
Dimensión Empresarial     Open Access  
Discusiones Filosóficas     Open Access   (Followers: 1)
Dynamis : Acta Hispanica ad Medicinae Scientiarumque Historiam Illustrandam     Open Access   (Followers: 3, SJR: 0.131, CiteScore: 0)
e-J. of Portuguese History     Open Access   (Followers: 2, SJR: 0.101, CiteScore: 0)
e-Pública : Revista Eletrónica de Direito Público     Open Access   (Followers: 1)
Earth Sciences Research J.     Open Access   (Followers: 1)
Eclética Química     Open Access   (Followers: 1)
Ecología en Bolivia     Open Access  
Economia Aplicada     Open Access   (SJR: 0.208, CiteScore: 0)
Economia e Sociedade     Open Access  
Economía Mexicana. Nueva Época     Open Access   (Followers: 1)
EconoQuantum     Open Access  
Educação & Sociedade     Open Access   (Followers: 3)
Educação & Realidade     Open Access  
Educação e Pesquisa     Open Access   (Followers: 1, SJR: 0.163, CiteScore: 0)
Educação em Revista     Open Access  
Educación Matemática     Open Access  
Educación Médica     Open Access   (Followers: 1, SJR: 0.236, CiteScore: 0)
Educación Médica Superior     Open Access   (Followers: 1, SJR: 0.237, CiteScore: 0)
Educación y Educadores     Open Access  
Educar em Revista     Open Access  
EDUMECENTRO     Open Access  
Eidos     Open Access   (SJR: 0.119, CiteScore: 0)
En-Claves del pensamiento     Open Access   (Followers: 1, SJR: 0.194, CiteScore: 0)
Encuentros     Open Access  
Ene : Revista de Enfermería     Open Access  
Enfermería Global     Open Access   (Followers: 3, SJR: 0.165, CiteScore: 0)
Enfermería Nefrológica     Open Access   (Followers: 1, SJR: 0.198, CiteScore: 0)
Enfoques     Open Access  
Engenharia Agrícola     Open Access   (SJR: 0.305, CiteScore: 1)
Engenharia Sanitaria e Ambiental     Open Access   (SJR: 0.218, CiteScore: 0)
Ensaio Avaliação e Políticas Públicas em Educação     Open Access   (Followers: 1, SJR: 0.254, CiteScore: 0)
Ensayos de Economía     Open Access   (Followers: 1)
Ensayos Revista de Economía     Open Access  
Entomologia y Vectores     Open Access   (Followers: 2)
Entre Ciencia e Ingeniería     Open Access   (Followers: 1)
Epidemiologia e Serviços de Saúde     Open Access  
Escritos de Psicología : Psychological Writings     Open Access   (Followers: 2)
Espacios en Blanco : Revista de educación     Open Access  
Estudios Atacameños     Open Access   (Followers: 2, SJR: 0.446, CiteScore: 1)
Estudios Constitucionales     Open Access   (Followers: 5, SJR: 0.319, CiteScore: 0)
Estudios de Cultura Maya     Open Access   (Followers: 2, SJR: 0.272, CiteScore: 0)
Estudios de Economía     Open Access   (SJR: 0.121, CiteScore: 0)
Estudios de historia moderna y contemporánea de México     Open Access   (SJR: 0.101, CiteScore: 0)
Estudios Economicos     Open Access  
Estudios Filologicos     Open Access   (SJR: 0.107, CiteScore: 0)
Estudios Fronterizos     Open Access   (Followers: 1)
Estudios internacionales     Open Access   (Followers: 5)
Estudios Pedagogicos (Valdivia)     Open Access   (Followers: 1, SJR: 0.338, CiteScore: 0)
Estudios Políticos     Open Access  
Estudios Sociales     Open Access   (Followers: 2)
Estudios sociales : Revista de alimentación contemporánea y desarrollo regional     Open Access   (Followers: 1)
Estudios Socioterritoriales : Revista de Geografía     Open Access  
Estudios y Perspectivas en Turismo     Open Access   (Followers: 2)
Estudos Afro-Asiáticos     Open Access   (Followers: 2)
Estudos Avançados     Open Access   (SJR: 0.232, CiteScore: 0)
Estudos de Psicologia (Campinas)     Open Access   (Followers: 1, SJR: 0.233, CiteScore: 0)
Estudos de Psicologia (Natal)     Open Access   (SJR: 0.117, CiteScore: 0)
Estudos Econômicos     Open Access   (SJR: 0.204, CiteScore: 0)
Estudos Históricos     Open Access   (Followers: 1)
EURE (Santiago) - Revista Latinoamericana de Estudios Urbano Regionales     Open Access   (SJR: 0.38, CiteScore: 1)
Ex aequo     Open Access  
FEM : Revista de la Fundación Educación Médica     Open Access  
Fides et Ratio : Revista de Difusión Cultural y Científica     Open Access   (Followers: 1)
Fisioterapia e Pesquisa     Open Access  
Fisioterapia em Movimento     Open Access  
Fitosanidad     Open Access  
Floresta e Ambiente     Open Access   (Followers: 1, SJR: 0.3, CiteScore: 0)
Folios     Open Access  
Food Science and Technology (Campinas)     Open Access   (Followers: 1, SJR: 0.467, CiteScore: 1)
Formación Universitaria     Open Access   (Followers: 4, SJR: 0.213, CiteScore: 1)
Frónesis     Open Access   (Followers: 1)
Frontera Norte     Open Access  
Gaceta Médica Boliviana     Open Access  
Gaceta Médica Espirituana     Open Access  
Galáxia (São Paulo)     Open Access  
Gayana (Concepcion)     Open Access   (SJR: 0.236, CiteScore: 0)
Gayana. Botanica     Open Access   (SJR: 0.234, CiteScore: 0)
Genetics and Molecular Biology     Open Access   (Followers: 15, SJR: 0.638, CiteScore: 2)
Geofísica internacional     Open Access   (SJR: 0.312, CiteScore: 1)
Gerokomos     Open Access   (Followers: 1, SJR: 0.257, CiteScore: 0)
Gestão & Produção     Open Access   (SJR: 0.156, CiteScore: 0)
Gestión y Política Pública     Open Access   (Followers: 2, SJR: 0.106, CiteScore: 0)
Hacia la Promoción de la Salud     Open Access  
Hallazgos     Open Access   (Followers: 1)
Hidrobiológica     Open Access   (SJR: 0.166, CiteScore: 0)
Historia     Open Access   (Followers: 2)
Historia (Santiago)     Open Access   (Followers: 1, SJR: 0.162, CiteScore: 0)
História (São Paulo)     Open Access   (SJR: 0.11, CiteScore: 0)
História, Ciências, Saúde - Manguinhos     Open Access   (Followers: 2, SJR: 0.144, CiteScore: 0)
Hoehnea     Open Access  
Horizonte Sanitario     Open Access   (Followers: 1)
Horizontes Antropológicos     Open Access   (Followers: 3, SJR: 0.233, CiteScore: 0)
Horticultura Brasileira     Open Access   (SJR: 0.605, CiteScore: 1)
HTS Theological Studies     Open Access   (Followers: 8, SJR: 0.448, CiteScore: 0)
Humanidades Médicas     Open Access  
IDESIA : Revista de Agricultura en Zonas Áridas     Open Access   (SJR: 0.223, CiteScore: 0)
Iheringia. Série Zoologia     Open Access   (Followers: 1, SJR: 0.26, CiteScore: 1)
Íkala : Revista de Lenguaje y Cultura     Open Access   (Followers: 1, SJR: 0.112, CiteScore: 0)
Image & Text     Open Access   (Followers: 1)
Index de Enfermeria     Open Access   (Followers: 7, SJR: 0.113, CiteScore: 0)
Indo-Pacific J. of Phenomenology     Open Access   (Followers: 1)
Infectio     Open Access   (SJR: 0.133, CiteScore: 0)
Información Tecnológica     Open Access   (SJR: 0.197, CiteScore: 0)
Ingeniare : Revista Chilena de Ingenieria     Open Access   (Followers: 1, SJR: 0.239, CiteScore: 0)
Ingeniería Electrónica, Automática y Comunicaciones     Open Access  
Ingeniería Hidráulica y Ambiental     Open Access  
Ingeniería Industrial     Open Access  
Ingeniería Mecánica     Open Access   (Followers: 4)
Ingenieria Mecánica. Tecnologia y Desarrollo     Open Access   (Followers: 3)
Ingeniería y Competitividad     Open Access  
Ingeniería y Desarrollo     Open Access  
Ingenieria y Universidad     Open Access   (Followers: 1, SJR: 0.161, CiteScore: 1)
Ingeniería, Investigación y Tecnología     Open Access   (Followers: 1)
Innovar     Open Access   (SJR: 0.118, CiteScore: 0)
Interações (Campo Grande)     Open Access  
Interface - Comunicação, Saúde, Educação     Open Access   (Followers: 1, SJR: 0.417, CiteScore: 0)
Intersticios Sociales     Open Access   (Followers: 1)
Intervención     Open Access   (Followers: 1)
Intervención Psicosocial     Open Access   (SJR: 0.381, CiteScore: 1)
Intl. Brazilian J. of Urology     Open Access   (Followers: 5, SJR: 0.367, CiteScore: 1)
Intl. J. of Morphology     Open Access  
Intl. J. of Odontostomatology     Open Access   (Followers: 1)
Intl. Law: Revista Colombiana de Derecho Internacional     Open Access   (Followers: 3)
Investigación Administrativa     Open Access   (Followers: 1)
Investigación Bibliotecológica     Open Access   (Followers: 6, SJR: 0.274, CiteScore: 0)
Investigación Económica     Open Access   (Followers: 4, SJR: 0.132, CiteScore: 0)
Investigación y Desarrollo     Open Access   (Followers: 1)
Investigación y Educación en Enfermería     Open Access   (Followers: 1, SJR: 0.198, CiteScore: 0)
Investigaciones Geográficas     Open Access   (SJR: 0.246, CiteScore: 0)
Investigaciones Marinas     Open Access  
Iteckne     Open Access  
Iuris Tantum Revista Boliviana de Derecho     Open Access  
Ius et Praxis     Open Access   (SJR: 0.283, CiteScore: 0)
Izquierdas     Open Access   (SJR: 0.188, CiteScore: 0)
Iztapalapa : Revista de ciencias sociales y humanidades     Open Access   (Followers: 1)
J. of Applied Oral Science     Open Access   (SJR: 0.645, CiteScore: 2)
J. of Applied Research and Technology     Open Access   (SJR: 0.255, CiteScore: 1)
J. of Coloproctology     Open Access   (SJR: 0.167, CiteScore: 0)
J. of Energy in Southern Africa     Open Access   (Followers: 3, SJR: 0.249, CiteScore: 1)
J. of Epilepsy and Clinical Neurophysiology     Open Access   (Followers: 7)
J. of Microwaves, Optoelectronics and Electromagnetic Applications     Open Access   (Followers: 11, SJR: 0.146, CiteScore: 1)
J. of Seed Science     Open Access   (Followers: 1)
J. of Soil Science and Plant Nutrition     Open Access   (Followers: 12, SJR: 0.823, CiteScore: 2)
J. of Technology Management & Innovation     Open Access   (Followers: 5, SJR: 0.271, CiteScore: 1)
J. of the Brazilian Chemical Society     Open Access   (Followers: 2, SJR: 0.357, CiteScore: 1)
J. of the Brazilian Society of Mechanical Sciences     Open Access   (Followers: 2)
J. of the Chilean Chemical Society     Open Access   (Followers: 2, SJR: 0.201, CiteScore: 1)
J. of the Mexican Chemical Society     Open Access   (Followers: 2, SJR: 0.214, CiteScore: 1)
J. of the Selva Andina Research Society     Open Access   (Followers: 3)
J. of the South African Institution of Civil Engineering     Open Access   (Followers: 2, SJR: 0.174, CiteScore: 0)
J. of the Southern African Institute of Mining and Metallurgy     Open Access   (Followers: 6)
J. of Theoretical and Applied Electronic Commerce Research     Open Access   (Followers: 1, SJR: 0.477, CiteScore: 2)
J. of Venomous Animals and Toxins     Open Access   (Followers: 2)
JISTEM : J. of Information Systems and Technology Management     Open Access   (Followers: 7)
Jornal Brasileiro de Nefrologia     Open Access   (SJR: 0.334, CiteScore: 1)
Jornal Brasileiro de Patologia e Medicina Laboratorial     Open Access   (SJR: 0.143, CiteScore: 0)
Jornal Brasileiro de Pneumologia     Open Access   (SJR: 0.448, CiteScore: 1)
Jornal Brasileiro de Psiquiatria     Open Access   (Followers: 3, SJR: 0.224, CiteScore: 0)
Jornal da Sociedade Brasileira de Fonoaudiologia     Open Access  
Jornal de Pneumologia     Open Access  
Jornal Vascular Brasileiro     Open Access   (SJR: 0.136, CiteScore: 0)
Justicia Juris     Open Access  
Kriterion: Revista de Filosofia     Open Access   (Followers: 1, SJR: 0.114, CiteScore: 0)
Kronos : Southern African Histories     Open Access   (Followers: 6)
La ventana. Revista de estudios de género     Open Access  
La zaranda de ideas     Open Access   (Followers: 1)
Laboreal     Open Access  
Lankesteriana     Open Access   (SJR: 0.458, CiteScore: 1)
Latin American Applied Research     Open Access   (Followers: 1)
Latin American J. of Aquatic Research     Open Access   (SJR: 0.289, CiteScore: 1)

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Journal of Venomous Animals and Toxins
Number of Followers: 2  

  This is an Open Access Journal Open Access journal
ISSN (Online) 0104-7930
Published by SciELO Homepage  [911 journals]
  • Scielo and scientific electronic publishing in Brazil

    •  
  • Anti-inflammatory activity of propolis extracts: a review

    • Abstract: Since primeval times, the inflammatory process has been described in many different ways. Several anti-inflammatory therapies have been used in different biological models. However, in a recent "back to nature move", modern man is searching for natural products with medicinal properties, particularly those obtained from plants and bees. Propolis has been used in folk medicine for a very long time. The many compounds present in propolis require investigation.Physical-chemical analysis studies have not sufficiently established quality standards of propolis containing products. These standards should depend especially on their different pharmacological activities. There are few studies reporting on the in vitro anti-inflammatory activity of propolis containing products. It is necessary to evaluate the anti-inflammatory potential of commercial products containing propolis.
       
  • In vitro assay of biological and chemical toxins using antibodies against
           lethal toxin neutralizing factor

    • Abstract: Lethal Toxin Neutralizing Factor (N-LTNF), MW 63.0 kDa, was isolated from opossum serum. After trypsin digestion, the active domain of N-LTNF was isolated and sequenced. The synthetic peptide consisting of ten amino acids was designated as LT-10. N-LTNF and LT-10 inhibited the lethality of animal, plant and bacteria toxins when tested on mice non-immunologically. The antibodies against N-LTNF and LT-10 only reacted immunologically with toxins and not with non-toxic substances. Anti-LTNF and anti-LT-10 reacted immunologically by ELISA test with toxins that were not detected by mouse test, such as cholera toxin and digoxin. Anti-LTNF and anti-LT-10 failed to react immunologically with non-toxic substances, such as nerve growth factor and collagen. Currently, mouse bioassay is in use for toxin detection and assay. Binding affinity of IgG from anti-LT-10 showed a linear relationship with mouse bioassay by ELISA detection limit to some toxins only. This may be due to the fact that anti-LTNF and anti-LT-10 detected the toxins that were not lethal to mouse. Thus, anti-LTNF and anti-LT-10 can be useful in assaying toxins as an alternative to mouse bioassay.
       
  • Rabbit antivenom efficacy against myotoxic and neurotoxic activities of
           Bothrops jararacussu venom and bothropstoxin-I

    • Abstract: Bothrops jararacussu venom and its major toxin bothropstoxin-I (BthTX-I) possess myotoxic and neurotoxic properties. The efficacy of a rabbit antivenom raised against B. jararacussu venom in the neutralization of physiological, biochemical, and morphological changes induced by the venom and its major toxin BthTX-I was studied in mouse isolated phrenic nerve-diaphragm (PND) and extensor digitorum longus (EDL) preparations. The times required for 50% neuromuscular blockade in PND and EDL preparations for venom were 70+11.5 (S.E.M., n=5) min and 58+8 (n=16) (50 mu g/mL), and for BthTX-I 31+6 (n=3) min and 30+3 (n=5) min (20 mu g/mL), respectively. After 120 min incubation, creatine kinase (CK) concentrations in solution containing the EDL preparations were 3464+346 U/L after exposure to venom (50 mu g/mL, n=5) and 3422+135 U/L to BthTX-I (20mu g/mL, n=4), respectively. Rabbit antivenom dose-dependently neutralized venom and toxin-induced neuromuscular blockade in both preparations and effectively prevented venom and toxin-induced CK release from EDL. Histological analysis showed that rabbit antivenom neutralized morphological damage caused by B. jararacussu venom and BthTX-I in EDL preparations. These results indicate that rabbit antivenom effectively neutralized the biological activities of B. jararacussu venom and BthTX-I.
       
  • Seasonal effect of Brazilian propolis on seric biochemical variables

    • Abstract: Propolis has been the subject of recent scientific investigation due to its biological properties, such as antibiotic, antiinflammatory, anesthetic, healing, immunomodulatory, antioxidant, and carcinostatic. The purpose of this study was to analyze the biochemical profile of propolis-treated rats to observe whether propolis might lead to side effects after administration. Evaluation of total protein, glucose, urea, creatinine, triglycerides, cholesterol, and HDL-cholesterol concentrations and determination of aminotransferases (AST and ALT) and lactic dehydrogenase (LDH) in propolis-treated rat serum were performed. The seasonal effect on propolis activity was also analyzed, considering the biochemical variables evaluated. The lack of clinically important changes in seric biochemical variables is probably because propolis showed no biological side effects under these conditions. A possible seasonal effect on the biochemical determinations was not observed.
       
  • Sub-lethal injection of honeybee venom decreased the levels of
           endogenously present substances in organs of mice

    • Abstract: Pharmacological substances such as adenosine deaminase (ADA), collagen, histamine, IgE, myoglobin, and nerve growth factor (NGF) are endogenously present in animals. Research from this laboratory reported decreased levels of ADA, histamine, IgE, and NGF in organs of mice injected with sub-lethal doses of cobra venom. The goal of this research is to observe the levels of ADA, collagen, histamine, IgE, myoglobin, and NGF in certain organs of mice injected with venom from the bee Apis mellifera. Adult Balb/c female mice IM injected with half lethal dose of bee venom were sacrificed after 2 and 8 hours for removal of organs. The homogenates of the organs were assayed by ELISA for ADA, collagen, histamine, IgE, myoglobin, and NGF using respective antisera. Organs from mice injected with PBS were used as controls. It was observed that there were decreased levels of ADA, collagen, histamine, IgE, myoglobin, and NGF in certain organs after 2 h and tremendous decrease after 8 h. This is the first report showing the pharmacokinetics of ADA, collagen, histamine, IgE, myoglobin, and NGF as consequence of honeybee envenomation.
       
  • Some toxinological aspects of Aurelia aurita (Linné) from the
           Mexican Caribbean

    • Abstract: Aurelia aurita is a scyphozoan, abundant in the Mexican Caribbean during summer. Although usually innocuous, there is evidence of it causing harm to humans. This work investigates the biological activities of crude and fractionated extracts of A. aurita. Live specimens were collected between July and September 1999 from the Mexican Caribbean. The tentacular margin was dissected immediately and frozen at -50ºC. A nematocyst suspension was prepared, discharged, and the supernatants lyophilized. Hemolytic assay was performed with lyophilized crude extract on bovine, sheep, and human red blood cells. Erythrocyte sensitivity to the toxin was ranked in descending order: human, sheep, and bovine. Toxic activity on Artemia nauplii was evaluated using the same crude extract for different exposure periods (3, 5, and 10 hours); only 48 and 72 hour old Artemia nauplii showed 50% mortality. Partial toxin purification was completed by sequential liquid chromatography using three gels (Sephadex G-200, DEAE Sephadex A-50, and Sephadex G-100). Intramuscular neuroactivity was detected in the crab Ocypode quadrata for two partially purified fractions. These fractions were found to have molecular weight components of 66 and 45 kDa, respectively.
       
  • Antitumor and biochemical effects of Echis coloratus crude venom on
           Ehrlich ascites carcinoma cells in vivo

    • Abstract: The search for snake venom antitumor efficacy has attracted the interest of scientists since the beginning of last century. Snake venom possesses a wide spectrum of biological activities. In this study, we evaluated the effect of Echis coloratus crude venom on the evolution of Ehrlich ascites carcinoma cells (EAC). Normal and EAC-bearing mice were treated with 0.2 mg/kg body weight of crude venom. Crude venom was seen to suppress tumor growth by significantly decreasing EAC cell count and cell viability (p
       
  • Humoral response and neutralization capacity of sheep serum inoculated
           with natural and Cobalt 60-irradiated Crotalus durissus terrificus venom
           (Laurenti, 1768)

    • Abstract: The aim of this work was to investigate antigen irradiation on crotalic antivenom and the capacity of sheep as serum producers. Twelve sheep in two groups of six were inoculated with Crotalus durissus terrificus venom. One group was inoculated with natural venom (NV) and the other with Cobalt 60 gamma-irradiated venom (IrV). Three antigen doses were given to the animals at monthly intervals for immunization. The toxic activity of the venom was assessed by LD50 determination in mice. Blood samples were collected weekly analyses of serum neutralization capacity and potency. At the end of the experiment, the animals were challenged with a LD50 for sheep showed no signs of envenoming. These results showed that toxicity of the irradiated venom was 4.4 times less than the natural venom. The sera from the irradiated group neutralized LD50 14.6 times, and the sera from the natural group 4.4 times. Sera from the irradiated group were five times more potent. The two groups did not present clinical alterations. The results of this study show the potential for using sheep in crotalic antivenom production. The use of irradiated venom in sheep immunization induces a powerful and lasting humoral immune response shown by both the in vitro neutralization and potency tests and by the indirect ELISA antibody level detection technique.
       
  • Neuromuscular blocking action of the Theraphosa blondii spider
           venom

    • Abstract: In 1919, Houssay and Negrete reported that venoms of Theraphosidae spiders induced neuromuscular blockade. In 1993, a purified toxin from Grammostola spider venom was found to block the P-type voltage-dependent calcium channel (VDCC), causing neuromuscular blockade. We studied the mode of action of Theraphosa blondii venom, a large Theraphosidae spider from Northern Brazil, Venezuela, and The Guyanas in mouse phrenic nerve-diaphragm preparation. This venom elicited a partially reversible neuromuscular blockade and did not depress directly evoked twitches or alter the membrane potential. Neostigmine produced only a poor antagonistic effect on partially blocked diaphragms. However, completely blocked miniature endplate potentials (m.e.p.ps) were reverted by neostigmine. These results can be explained by the presence of toxins in the venom that interact with the endplate receptor at the acetylcholine sites (curaremimetic toxins) and toxins that inhibit the P-type voltage-dependent calcium channel (VDCC) (omega -toxins). This study shows that Theraphosidae venoms, especially those of the Theraphosa blondii, are a source of curaremimetic toxins and omega -toxins of possible interest as tools in bioscientific research.
       
  • Use of snake venom derived fibrin glue for the immobilization of free
           gingival grafts: clinical and histological study

    • Abstract: In 1919, Houssay and Negrete reported that venoms of Theraphosidae spiders induced neuromuscular blockade. In 1993, a purified toxin from Grammostola spider venom was found to block the P-type voltage-dependent calcium channel (VDCC), causing neuromuscular blockade. We studied the mode of action of Theraphosa blondii venom, a large Theraphosidae spider from Northern Brazil, Venezuela, and The Guyanas in mouse phrenic nerve-diaphragm preparation. This venom elicited a partially reversible neuromuscular blockade and did not depress directly evoked twitches or alter the membrane potential. Neostigmine produced only a poor antagonistic effect on partially blocked diaphragms. However, completely blocked miniature endplate potentials (m.e.p.ps) were reverted by neostigmine. These results can be explained by the presence of toxins in the venom that interact with the endplate receptor at the acetylcholine sites (curaremimetic toxins) and toxins that inhibit the P-type voltage-dependent calcium channel (VDCC) (omega -toxins). This study shows that Theraphosidae venoms, especially those of the Theraphosa blondii, are a source of curaremimetic toxins and omega -toxins of possible interest as tools in bioscientific research.
       
 
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