Publisher: SciELO   (Total: 912 journals)

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Showing 1 - 200 of 912 Journals sorted alphabetically
Abanico Veterinario     Open Access   (Followers: 2)
ABCD. Arquivos Brasileiros de Cirurgia Digestiva     Open Access   (Followers: 3, SJR: 0.207, CiteScore: 1)
ACIMED     Open Access   (Followers: 1)
Acta Agronómica     Open Access  
Acta Amazonica     Open Access   (Followers: 6, SJR: 0.36, CiteScore: 1)
Acta Bioethica     Open Access   (SJR: 0.196, CiteScore: 0)
Acta Bioquimica Clinica Latinoamericana     Open Access   (Followers: 1)
Acta Botanica Brasilica     Open Access   (Followers: 3, SJR: 0.325, CiteScore: 1)
Acta botánica mexicana     Open Access   (Followers: 1, SJR: 0.212, CiteScore: 0)
Acta Botánica Venezuelica     Open Access   (Followers: 1, SJR: 0.103, CiteScore: 0)
Acta Cirurgica Brasileira     Open Access   (SJR: 0.395, CiteScore: 1)
Acta Limnologica Brasiliensia     Open Access   (Followers: 4, SJR: 0.28, CiteScore: 1)
Acta Literaria     Open Access   (Followers: 5, SJR: 0.1, CiteScore: 0)
Acta Medica Colombiana     Open Access   (Followers: 1)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Medica Peruana     Open Access   (Followers: 2)
Acta Neurológica Colombiana     Open Access   (Followers: 2)
Acta Nova     Open Access   (Followers: 1)
Acta Obstétrica e Ginecológica Portuguesa     Open Access   (Followers: 1)
Acta Ortopédica Brasileira     Open Access   (Followers: 1, SJR: 0.343, CiteScore: 1)
Acta Paulista de Enfermagem     Open Access   (Followers: 2, SJR: 0.275, CiteScore: 1)
Acta Pediátrica Costarricense     Open Access   (Followers: 1)
Acta Poética     Open Access   (Followers: 4, SJR: 0.101, CiteScore: 0)
Acta Portuguesa de Nutrição     Open Access   (Followers: 1)
Acta Scientiarum. Agronomy     Open Access   (Followers: 6, SJR: 0.431, CiteScore: 1)
Acta Scientiarum. Animal Sciences     Open Access   (Followers: 4, SJR: 0.25, CiteScore: 0)
Acta zoológica mexicana     Open Access   (Followers: 1)
Actas Odontológicas     Open Access   (Followers: 1)
Actualidades Biológicas     Open Access   (Followers: 1)
African Human Rights Law J.     Open Access   (Followers: 18)
African Natural History     Open Access   (Followers: 4, SJR: 0.198, CiteScore: 1)
Afro-Asia     Open Access  
Ágora - studies in psychoanalytic theory     Open Access   (Followers: 3, SJR: 0.132, CiteScore: 0)
Agricultura Tecnica     Open Access   (Followers: 5)
Agricultura, Sociedad y Desarrollo     Open Access   (Followers: 3)
Agrociencia     Open Access   (Followers: 1, SJR: 0.2, CiteScore: 0)
Agrociencia Uruguay     Open Access  
Agronomía Mesoamericana     Open Access   (Followers: 1)
Agronomía Tropical     Open Access   (Followers: 1)
Aisthesis     Open Access   (Followers: 7, SJR: 0.106, CiteScore: 0)
Ajayu Órgano de Difusión Científica del Departamento de Psicología UCBSP     Open Access  
Alea : Estudos Neolatinos     Open Access   (Followers: 2, SJR: 0.1, CiteScore: 0)
Aletheia : Revista de Desarrollo Humano, Educativo y Social Contemporáneo     Open Access   (Followers: 1)
Alfa : Revista de Linguística     Open Access  
Alpha (Osorno)     Open Access   (SJR: 0.138, CiteScore: 0)
Alteridades     Open Access   (Followers: 2)
Ambiente & sociedade     Open Access   (Followers: 3, SJR: 0.235, CiteScore: 0)
Ambiente & Agua : An Interdisciplinary J. of Applied Science     Open Access   (Followers: 1, SJR: 0.263, CiteScore: 1)
Ambiente Construído     Open Access   (Followers: 1)
América Latina en la historia económica     Open Access   (Followers: 4, SJR: 0.134, CiteScore: 0)
Anais Brasileiros de Dermatologia     Open Access   (Followers: 2, SJR: 0.52, CiteScore: 1)
Anais da Academia Brasileira de Ciências     Open Access   (Followers: 2, SJR: 0.418, CiteScore: 1)
Anais do Museu Paulista : História e Cultura Material     Open Access  
Anales de Medicina Interna     Open Access   (Followers: 1)
Anales del Instituto de la Patagonia     Open Access  
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1, SJR: 0.157, CiteScore: 0)
Análise Psicológica     Open Access   (Followers: 1, SJR: 0.16, CiteScore: 0)
Análise Social     Open Access   (Followers: 3, SJR: 0.16, CiteScore: 0)
Análisis Economico     Open Access  
Andean geology     Open Access   (Followers: 9, SJR: 0.674, CiteScore: 1)
Anestesia Analgesia Reanimación     Open Access   (Followers: 1)
Anestesia en México     Open Access   (Followers: 1)
Antipoda : Revista de Antropología y Arqueología     Open Access   (Followers: 5, SJR: 0.135, CiteScore: 0)
Antropología Social y Cultural en Uruguay     Open Access   (Followers: 1)
Anuario Colombiano de Historia Social y de la Cultura     Open Access   (SJR: 0.1, CiteScore: 0)
Anuario de Historia Regional y de las Fronteras     Open Access  
Anuario de Letras : Lingüística y Filología     Open Access   (Followers: 1)
Apuntes : Revista de Estudios sobre Patrimonio Cultural - J. of Cultural Heritage Studies     Open Access   (Followers: 7)
Aquichán     Open Access   (Followers: 2, SJR: 0.137, CiteScore: 0)
Archivos de Medicina Interna     Open Access   (Followers: 1)
Archivos de Medicina Veterinaria     Open Access   (Followers: 1, SJR: 0.194, CiteScore: 0)
Archivos de Neurociencias     Open Access   (Followers: 3, SJR: 0.111, CiteScore: 0)
Archivos de Pediatria del Uruguay     Open Access   (Followers: 3)
Archivos de Prevención de Riesgos Laborales     Open Access   (Followers: 1)
Archivos de Zootecnia     Open Access   (Followers: 1, SJR: 0.202, CiteScore: 0)
Archivos Españoles de Urología     Open Access   (SJR: 0.178, CiteScore: 0)
Archivos Latinoamericanos de Nutrición     Open Access   (Followers: 1)
Archivos Venezolanos de Farmacología y Terapéutica     Open Access   (SJR: 0.101, CiteScore: 0)
Argos     Open Access   (Followers: 1)
ARQ     Open Access   (Followers: 6, SJR: 0.113, CiteScore: 0)
Arquitectura y Urbanismo     Open Access   (Followers: 4)
Arquivo Brasileiro de Medicina Veterinária e Zootecnia     Open Access   (SJR: 0.248, CiteScore: 0)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 2, SJR: 0.381, CiteScore: 1)
Arquivos Brasileiros de Endocrinologia e Metabologia     Open Access  
Arquivos Brasileiros de Oftalmologia     Open Access   (Followers: 1, SJR: 0.518, CiteScore: 1)
Arquivos Brasileiros de Psicologia     Open Access   (Followers: 1, SJR: 0.196, CiteScore: 0)
Arquivos de Gastroenterologia     Open Access   (Followers: 1, SJR: 0.396, CiteScore: 1)
Arquivos de Medicina     Open Access  
Arquivos de Neuro-Psiquiatria     Open Access   (SJR: 0.448, CiteScore: 1)
Arquivos do Instituto Biológico     Open Access   (Followers: 1)
Arquivos Internacionais de Otorrinolaringologia     Open Access  
ARS     Open Access   (Followers: 4)
Atenea (Concepción)     Open Access   (SJR: 0.112, CiteScore: 0)
Atmósfera     Open Access   (Followers: 3, SJR: 0.449, CiteScore: 1)
Audiology - Communication Research     Open Access   (Followers: 10)
Austral J. of Veterinary Sciences     Open Access   (Followers: 2)
Avaliação : Revista da Avaliação da Educação Superior (Campinas)     Open Access  
Avaliação Psicológica     Open Access   (SJR: 0.164, CiteScore: 0)
Avances en Enfermería     Open Access   (Followers: 2)
Avances en Odontoestomatologia     Open Access   (Followers: 1, SJR: 0.105, CiteScore: 0)
Avances en Periodoncia e Implantología Oral     Open Access   (Followers: 1)
Bakhtiniana : Revista de Estudos do Discurso     Open Access   (SJR: 0.103, CiteScore: 0)
BAR. Brazilian Administration Review     Open Access   (Followers: 2, SJR: 0.137, CiteScore: 0)
Bioagro     Open Access   (Followers: 1, SJR: 0.207, CiteScore: 0)
Biosalud     Open Access   (Followers: 1)
Biota Neotropica     Open Access   (SJR: 0.381, CiteScore: 1)
Biotecnología Aplicada     Open Access   (SJR: 0.146, CiteScore: 0)
Biotecnología en el Sector Agropecuario y Agroindustrial     Open Access  
Boletim Academia Paulista de Psicologia     Open Access  
Boletim de Ciências Geodésicas     Open Access   (SJR: 0.188, CiteScore: 0)
Boletim de Educação Matemática     Open Access   (SJR: 0.196, CiteScore: 0)
Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas     Open Access   (Followers: 1, SJR: 0.238, CiteScore: 0)
Boletin Chileno de Parasitologia     Open Access  
Boletín Científico : Centro de Museos. Museo de Historia Natural     Open Access   (Followers: 1)
Boletín de Filología     Open Access  
Boletín de la Sociedad Botánica de México     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Boletín de la Sociedad Geológica Mexicana     Open Access   (SJR: 0.291, CiteScore: 1)
Boletín del Museo Chileno de Arte Precolombino     Open Access   (Followers: 1, SJR: 0.233, CiteScore: 0)
Boletin Mexicano de Derecho Comparado     Open Access   (Followers: 2, SJR: 0.107, CiteScore: 0)
Bosque     Open Access   (Followers: 2, SJR: 0.29, CiteScore: 1)
Bragantia     Open Access   (Followers: 2, SJR: 0.555, CiteScore: 1)
Brazilian Archives of Biology and Technology     Open Access   (Followers: 3, SJR: 0.281, CiteScore: 1)
Brazilian Business Review     Open Access  
Brazilian Dental J.     Open Access   (Followers: 3, SJR: 0.476, CiteScore: 1)
Brazilian J. Geology     Open Access   (Followers: 1)
Brazilian J. of Biology     Open Access   (Followers: 3, SJR: 0.523, CiteScore: 1)
Brazilian J. of Chemical Engineering     Open Access   (Followers: 5, SJR: 0.395, CiteScore: 1)
Brazilian J. of Food Technology     Open Access   (Followers: 3, SJR: 0.206, CiteScore: 0)
Brazilian J. of Medical and Biological Research     Open Access   (SJR: 0.611, CiteScore: 2)
Brazilian J. of Microbiology     Open Access   (Followers: 5, SJR: 0.63, CiteScore: 2)
Brazilian J. of Oceanography     Open Access   (Followers: 1, SJR: 0.425, CiteScore: 1)
Brazilian J. of Oral Sciences     Open Access   (Followers: 2, SJR: 0.131, CiteScore: 0)
Brazilian J. of Pain (BrJP)     Open Access  
Brazilian J. of Physical Therapy     Open Access   (Followers: 2, SJR: 0.802, CiteScore: 2)
Brazilian J. of Plant Physiology     Open Access   (Followers: 3, SJR: 1.178, CiteScore: 3)
Brazilian J. of Veterinary Research and Animal Science     Open Access   (Followers: 8, SJR: 0.225, CiteScore: 0)
Brazilian Oral Research     Open Access  
Brazilian Political Science Review     Open Access   (Followers: 2)
Bulletin of the World Health Organization     Open Access   (Followers: 21, SJR: 2.532, CiteScore: 3)
Caderno CRH     Open Access   (Followers: 3, SJR: 0.233, CiteScore: 0)
Caderno de Estudos     Open Access  
Cadernos CEDES     Open Access   (Followers: 1, SJR: 0.119, CiteScore: 0)
Cadernos de Pesquisa     Open Access   (Followers: 2, SJR: 0.183, CiteScore: 0)
Cadernos de Saúde Pública     Open Access   (Followers: 1, SJR: 0.568, CiteScore: 1)
Cadernos de Tradução : Universidade Federal de Santa Catarina     Open Access  
Cadernos Metrópole     Open Access   (Followers: 1)
Cadernos Nietzsche     Open Access  
Cadernos Pagu     Open Access   (SJR: 0.356, CiteScore: 0)
Cadernos Saúde Coletiva     Open Access   (Followers: 1)
Caldasia     Open Access   (SJR: 0.195, CiteScore: 0)
Calidad en la educación     Open Access   (Followers: 1)
Case Reports     Open Access  
Cerâmica     Open Access   (Followers: 5, SJR: 0.186, CiteScore: 0)
CERNE     Open Access   (Followers: 1, SJR: 0.368, CiteScore: 1)
CES Medicina     Open Access  
CES Medicina Veterinaria y Zootecnia     Open Access   (Followers: 1)
CES Psicología     Open Access   (Followers: 1)
Chilean J. of Agricultural & Animal Sciences     Open Access   (Followers: 1)
Chilean J. of Agricultural Research     Open Access   (Followers: 1, SJR: 0.377, CiteScore: 1)
Chungara (Arica) - Revista de Antropologia Chilena     Open Access   (Followers: 1, SJR: 0.565, CiteScore: 1)
Ciência & Saúde Coletiva     Open Access   (Followers: 2, SJR: 0.566, CiteScore: 1)
Ciência & Educação (Bauru)     Open Access  
Ciência Animal Brasileira     Open Access   (Followers: 1, SJR: 0.216, CiteScore: 0)
Ciência da Informação     Open Access   (Followers: 1, SJR: 0.121, CiteScore: 0)
Ciencia del suelo     Open Access   (Followers: 1)
Ciência e Agrotecnologia     Open Access   (SJR: 0.383, CiteScore: 1)
Ciencia e Cultura     Open Access   (Followers: 1)
Ciencia e Ingenieria Neogranadina     Open Access  
Ciencia e Investigación Agraria     Open Access   (Followers: 1, SJR: 0.211, CiteScore: 0)
Ciencia forestal en México     Open Access  
Ciência Rural     Open Access   (Followers: 2, SJR: 0.337, CiteScore: 1)
Ciencia y Enfermeria - Revista Iberoamericana de Investigacion     Open Access   (Followers: 3, SJR: 0.158, CiteScore: 0)
Ciencias Marinas     Open Access   (Followers: 3, SJR: 0.414, CiteScore: 1)
Ciencias Psicológicas     Open Access  
Cirugia Plastica Ibero-Latinoamericana     Open Access   (SJR: 0.166, CiteScore: 0)
Cirujano General     Open Access   (Followers: 1)
Civilizar Ciencias Sociales y Humanas     Open Access   (Followers: 3)
Civitas - Revista de Ciências Sociais     Open Access   (Followers: 3)
CLEI Electronic J.     Open Access  
Clínica y Salud     Open Access   (SJR: 0.173, CiteScore: 0)
Clinics     Open Access   (SJR: 0.536, CiteScore: 1)
Co-herencia     Open Access   (SJR: 0.106, CiteScore: 0)
CoDAS     Open Access   (SJR: 0.267, CiteScore: 0)
Cofin Habana     Open Access   (Followers: 1)
Colombia Internacional     Open Access   (Followers: 1, SJR: 0.218, CiteScore: 0)
Compendio de Ciencias Veterinarias     Open Access   (Followers: 1)
Computación y Sistemas     Open Access   (SJR: 0.226, CiteScore: 1)
Comuni@cción     Open Access   (Followers: 1)
Comunicación y sociedad     Open Access   (Followers: 2, SJR: 0.327, CiteScore: 0)
Concreto y cemento. Investigación y desarrollo     Open Access   (Followers: 1)
Confines     Open Access  
Contaduría y Administración     Open Access   (SJR: 0.219, CiteScore: 0)
Contexto Internacional     Open Access  
Convergencia     Open Access   (Followers: 3, SJR: 0.196, CiteScore: 0)
Correo Científico Médico     Open Access  
Corrosão e Protecção de Materiais     Open Access  
Crop Breeding and Applied Biotechnology     Open Access   (Followers: 3, SJR: 0.609, CiteScore: 1)
CT&F - Ciencia, Tecnología y Futuro     Open Access   (Followers: 1, SJR: 0.138, CiteScore: 0)
Cuadernos de Administración     Open Access   (SJR: 0.118, CiteScore: 0)

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Brazilian Oral Research
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1806-8324 - ISSN (Online) 1807-3107
Published by SciELO Homepage  [912 journals]
  • Adhesive resistance of a copaiba oil-based dentin biomodifier

    • Abstract: This study analyzed the effect of prior application of copaiba oil (CO) emulsions as a dentin cleaning substance on microleakage and microtensile adhesive strength. Twenty-five premolars and sixty-four molars were used for microleakage and microtensile assays. For the microleakage assays, specimens with standard class V cavities were divided (n = 5), according to the tested CO emulsions: CO10%X, CO10%Y, and CO10%Z, as well as chlorhexidine 2% (CHX) and distilled water (DW), as positive and negative controls, respectively. Restorations were performed using the Adper Single Bond® and/or Clearfil SE Bond® systems. Cervical, occlusal, distal and mesial sections were assessed for tracer penetration degree at the composite/tooth interface. For the microtensile assay, healthy molars were divided into sixteen groups, in which artificial caries were induced in half of the groups. Dentin surfaces were treated with CO10%X and CO10%Y, CHX and DW. Microtensile bond strength was measured by fixing each sample to the plate of a universal testing machine operated at a speed of 0.5 mm/minute until failure. Dentin treated with CO10%X showed a lower infiltration rate than dentin treated with the other CO emulsions, CHX2% and DW. According to the microtensile assay, both healthy and affected dentin treated with CO10%X and Adper Single Bond® adhesive system presented higher adhesive strength. CO emulsion, used as a dentin biomodifier, interfered positively in microleakage and improved adhesive strength after acid etching in the Adper Single Bond® adhesive system, or before applying the Clearfil SE Bond® self-etching system.
       
  • Esthetic perception of facial profile changes after extraction and
           nonextraction Class II treatment

    • Abstract: This retrospective study evaluated facial profile pleasantness determined by two protocols of Class II treatment. The sample comprised facial profile silhouettes obtained retrospectively from the pretreatment (T1) and posttreatment (T2) cephalograms of 60 patients (42 males and 18 females) divided into two groups. One group of 30 patients (mean age of 12.84 years) was treated with the extraction of maxillary first premolars (mean treatment time of 2.7 years), and the other group of 30 patients (mean age of 12.81 years) was treated with a mandibular advancement appliance (Forsus) (mean treatment time of 2.49 years). The facial profile silhouettes (T1 and T2) were randomly distributed in an album containing one patient per sheet. The examiners consisted of 60 orthodontists and 60 lay individuals, who analyzed the profiles in regard to facial pleasantness, using the Likert scale. A comparison between stages T1 and T2 of the two treatment protocols and between the examiners was performed by mixed-design analysis of variance at a significance level of 5%. The results demonstrated a significant difference between T1 and T2 (greater scores for T2 compared to T1), and between lay individuals and orthodontists (orthodontists assigned higher scores), but with no significant difference between the treatment protocols. Both protocols produced positive effects on the facial profile esthetics, from the standpoint of lay individuals and orthodontists.
       
  • Microstructural and mechanical analysis of two CAD-CAM lithium disilicate
           glass-reinforced ceramics

    • Abstract: The aim of this study was to analyze the structural, morphological and mechanical properties of two different lithium disilicate glass-reinforced ceramics for CAD-CAM systems (IPS e.max CAD and Rosetta SM). Five methodologies were used for both ceramics: microstructure (n = 2) was analyzed using x-ray diffraction (XRD); morphological properties (n = 2) were analyzed by scanning electron microscopy (SEM), with and without hydrofluoric etching; porosity (n = 3) was assessed using 3D micro-computed tomography (micro-CT); flexural strength was measured (n =1 0) using the three-point bending test; and bond strength was determined with self-adhesive resin cement (n = 10), using a microshear bond test. After performing all the tests, the data were analyzed using t-Student test and two-way ANOVA. All the tests used a significance level of α = 0.05. High peak positions corresponding to standard lithium metasilicate and lithium disilicate with similar intensities were observed for both ceramics in the XRD analysis. Morphological analysis showed that the crystalline structure of the two ceramics studied showed no statistical difference after acid etching. Additionally, no significant differences were recorded in the number or size of the pores for the ceramics evaluated. Moreover, no differences in flexural strength were found for the ceramic materials tested, or in the bond strength to ceramic substrates for the resin cements. Based on the study results, no significant differences were found between the two CAD-CAM lithium disilicate glass-reinforced ceramics tested, since they presented similar crystalline structures with comparable intensities, and similar total porosity, flexural strength and bond strength.
       
  • The effect of ionizing radiation on properties of fluoride-releasing
           restorative materials

    • Abstract: The purpose of this study was to evaluate the effect of ionizing radiation from high energy X-ray on fluoride release, surface roughness, flexural strength, and surface chemical composition of the materials. The study groups comprised five different restorative materials: Beautifil II, GCP Glass Fill, Amalgomer CR, Zirconomer, and Fuji IX GP. Twenty disk-shaped specimens (8x2 mm) for fluoride release and 20 bar-shaped specimens (25 x 2x 2 mm) for flexural strength were prepared from each material. Each material group was divided into two subgroups: irradiated (IR) and non-irradiated (Non-IR). The specimens from IR groups were irradiated with 1.8 Gy/day for 39 days (total IR = 70.2 Gy). The amount of fluoride released into deionized water was measured using a fluoride ion-selective electrode and ion analyzer after 24 hours and on days 2, 3, 7, 15, 21, 28, 35, and 39 (n = 10). The flexural strength was evaluated using the three-point bending test (n = 10). After the period of measurement of fluoride release, seven specimens (n = 7) from each group were randomly selected to evaluate surface roughness using AFM and one specimen was randomly selected for the SEM and EDS analyses. Data were analyzed with two-way ANOVA and Tukey tests (p = 0.05). The irradiation significantly increased fluoride release and surface roughness for Amalgomer CR and Zirconomer groups (p < 0.05). No significant change in flexural strength of the materials was observed after irradiation (p > 0.05). The ionizing radiation altered the amount of fluoride release and surface roughness of only Amalgomer CR and Zirconomer. The effect could be related to the chemical compositions of materials.
       
  • Smad1/5 signal transduction regulates the ameloblastic differentiation of
           induced pluripotent stem cells

    • Abstract: Induced pluripotent stem (iPS) cells could be induced into ameloblast-like cells by ameloblasts serum-free conditioned medium (ASF-CM), and bone morphogenetic proteins (BMPs) might be essential during the regulation of this process. The present study investigates the signal transduction that regulates the ameloblastic differentiation of iPS cells induced by ASF-CM. Mouse iPS cells were characterized and then cultured for 14 days in epithelial cell medium (control) or ASF-CM. Bone morphogenetic protein receptor II (BMPR-II) siRNA, inhibitor of Smad1/5 phosphorylation activated by activin receptor-like kinase (ALK) receptors, and inhibitors of mitogen-activated protein kinases (MAPKs) phosphorylation were used to treat the iPS cells in combination with ASF-CM. Real-time PCR, western blotting, and immunofluorescent staining were used to evaluate the expressions of ameloblast markers ameloblastin, enamelin, and cytokeratin-14. BMPR-II gene and protein levels increased markedly in ASF-CM-treated iPS cells compared with the controls, while the mRNA levels of Bmpr-Ia and Bmpr-Ib were similar between the ASF-CM and control groups. ASF-CM stimulation significantly increased the gene and protein expression of ameloblastin, enamelin and cytokeratin-14, and phosphorylated SMAD1/5, p38 MAPK, and ERK1/2 MAPK compared with the controls. Knockdown of BMPR-II and inhibition of Smad1/5 phosphorylation both could significantly reverse the increased expression of ameloblastin, enamelin, and cytokeratin-14 induced by ASF-CM, while neither inhibition of p38 nor ERK1/2 phosphorylation had significant reversing effects. We conclude that smad1/5 signaling transduction, activated by ALK receptors, regulates the ameloblastic differentiation of iPS cells induced by ameloblast-conditioned medium.
       
  • Cyclosporine A impairs bone repair in critical defects filled with
           different osteoconductive bone substitutes

    • Abstract: The aim of this study was to assess the influence of cyclosporine administration on the repair of critical-sized calvaria defects (CSDs) in rat calvaria filled with diverse biomaterials. Sixty animals were divided into two groups: the control (CTR) group (saline solution) and the cyclosporine (CCP) group (cyclosporine, 10 mg/kg/day). These medications were administered daily by gavage, beginning 15 days before the surgical procedure and lasting until the day the animals were euthanized. A CSD (5 mm Ø) was made in the calvaria of each animal, which was allocated to one of 3 subgroups, according to the biomaterial used to fill the defect: coagulum (COA), deproteinized bovine bone (DBB), or biphasic calcium phosphate ceramics of hydroxyapatite and β-phosphate tricalcium (HA/TCP). Euthanasia of the animals was performed 15 and 60 days after the surgical procedure (n = 5 animals/period/subgroup). Bone repair (formation) assessment was performed through microtomography and histometry, while the analyses of the expression of the BMP2, Osteocalcin, and TGFβ1 proteins were performed using immunohistochemistry. The CSDs not filled with biomaterials demonstrated lower bone formation in the CCP group. At 15 days, less bone formation was observed in the CSDs filled with DBB, a smaller volume of mineralized tissue was observed in the CSDs filled with HA/TCP, and the expression levels of BMP2 and osteocalcin were lower in the CCP group compared to the CTR group. The use of cyclosporine impaired bone repair in CSD, and this effect can be partially explained by the suppression of BMP2 and osteocalcin expression.
       
  • Effects of restraint stress and high-fat diet on osseointegration of
           titanium implants: an experimental study

    • Abstract: This study aimed to investigate the effects of chronic restraint stress (RS) and a high-fat diet (HFD) on the osseointegration of titanium implants in a rat model. After the surgical insertion of titanium implants into the metaphysis of the tibial bone, the rats were randomly divided into four equal groups (n = 8 each): control (CNT), restraint stress (RS), high-fat diet (HFD), and restraint stress plus high fat diet (RS-HFD). CNT: Rats received no further treatment during the 92-day experimental period. RS: Stress was applied to the rats beginning from two days after the implant surgery for one hour per day for the first 30 days, two hours per day for the next 30 days, and three hours per day for the last 30 days. HFD: Rats were fed a HFD for the following 90 days starting two days after surgery. RS-HFD: Rats were fed a HFD and RS was applied to rats for the following 90 days, starting two days after surgery. At the end of the experimental period, the rats were euthanized, and the implants and surrounding bone tissues were removed for histological analysis. Statistical analysis was performed by one way ANOVA and Bonferrroni tests. There were no significant differences in the bone–implant connection levels between the groups (p > 0.05), but in the HFD and RS-HFD groups, the bone filling ratios were found to be lower compared with the controls (p < 0.05) The data analyzed in this study suggest that an HFD with or without chronic RS adversely affected bone tissue in the rats during the 90-day osseointegration period.
       
  • Effect of the sense of coherence and associated factors in the quality of
           life of head and neck cancer patients

    • Abstract: The sense of coherence (SOC) is a measure of global orientation regarding the ability of individuals to cope with stressful situations. The aim of the present study was to evaluate the association between SOC and quality of life (QoL) and clinical and sociodemographic characteristics among survivors of oral, oropharynx, hypopharynx, or larynx cancer. A cross-sectional study was conducted with 90 cancer patients in follow up at the Santa Maria University Hospital in southern Brazil who had completed conformal 3D radiotherapy at least three months earlier. QoL was assessed using the University of Washington Quality of Life (UW-QOL) questionnaire and SOC was measured using the Brazilian version of the SOC-13 questionnaire. Data on socio-demographic characteristics and the disease were obtained from patients’ charts. Oral clinical conditions were also evaluated. Associations between exploratory variables and mean UW-QOL scores were evaluated through Poisson regression and the results were presented as rate ratios (RR) and 95% confidence intervals (CI). The mean overall UW-QOL score was 67.90 (± 18.71). Moderate and high SOC scores were associated with higher mean UW-QOL scores, that is, individuals with a stronger SOC demonstrated better QoL, (p < 0.05). Regarding the clinical variables, individuals with advanced stage cancer and those with hyposalivation and trismus had poorer QoL (p < 0.05). Patients with a greater SOC reported a better quality of life. Our findings show the importance of focusing on psychosocial factors, which can alleviate the impact caused by the disease and improve the QoL of these patients.
       
  • Dental caries experience and associated factors in 12-year-old-children: a
           population based-study

    • Abstract: Relevant public policies in oral health have been implemented in Brazil since 2004. Changes in the epidemiological status of dental caries are expected, mainly in the child population. This study aimed to assess the dental caries experience and associated factors among 12-year-old children in the state of São Paulo, Brazil. A cross-sectional population-based study was conducted with data obtained from 415 cities, including a total of 26,325 schoolchildren who were included by the double-stage cluster technique, by lot and by systematic sampling. The statistical model included data from the São Paulo Oral Health Survey (SBSP 2015), the Human Development Index (HDI) and the Social Vulnerability Index (SVI). A theoretical-conceptual model categorized the variables into three blocks, namely, contextual (HDI, SVI, region of residence and fluoridation of water), individual (sex and ethnicity) and periodontal conditions (gingival bleeding, dental calculus and the presence of periodontal pockets), for association with the experience of caries (DMFT). Statistically significant associations were verified by hierarchical multivariate logistic (L) and Poisson (P) regression analyses (p < 0.05). The results showed that 57.7% of 12-year-old children had caries experience. Factors that determined a greater prevalence of dental caries in both models were nonwhite ethnicity (ORL = 1.113, ORP = 1.154) and the presence of gingival bleeding (ORL = 1.204, ORP = 1.255). Male children (ORL = 0.920 ORP = 0.859) and higher HDI (ORL = 0.022), ORP = 0.040) were associated with a lower prevalence of dental caries experience. Water fluoridation was associated with a lower DMFT index (ORP = 0.766). Dental caries experience is still associated with social inequalities at different levels. Policymakers should direct interventions towards reducing inequalities and the prevalence of dental caries among 12-year-old children.
       
  • Expression profile of salivary micro RNA-21 and 31 in oral potentially
           malignant disorders

    • Abstract: Oral potentially malignant disorders (OPMD) possess significant chances of malignancy conversion. In order to develop an early diagnostic tool, the present study evaluated the expression of miRNA-21 and 31 as salivary markers. The case-control study was carried out in 36 healthy participants as controls and in 36 patients who were newly diagnosed as OPMD having four different lesions including leucoplakia, oral sub mucous fibrosis (OSMF)궱, oral lichen planus, and (OSMF)궱 with leucoplakia. The samples were also classified as non-dysplastic, or with mild, moderate, and severe dysplasia according to their histopathological reports. The salivary miRNA-21 and 31 expressions were studied using real-time PCR. The statistical analysis was carried out using SPSS version 22. Salivary miRNA-21 (p-value = 0.02) and 31 (p-value = 0.01) were significantly upregulated in severe dysplasia compared with control. Among the different lesions, leucoplakia had significant upregulation of miRNA-21 and 31. miRNA-21 can be used as a diagnostic marker with specificity of 66% and sensitivity of 69%. The area under the ROC curve was 0.820 for miRNA-21 and 0.5 for miRNA-31, which proved that miRNA-21 is a better diagnostic marker than miRNA-31 for OPMD.
       
  • Pam2CSK4 (TLR2 agonist) induces periodontal destruction in mice

    • Abstract: Lipoproteins are important bacterial immunostimulating molecules capable of inducing receptor activator of nuclear factor-κB (RANKL) and osteoclast formation in vitro and in vivo . Although these molecules are present in periodontopathogenic bacteria, their role in periodontitis is not known. In this study, we used Pam2CSK4 (PAM2), a synthetic molecule that mimics bacterial lipoprotein, to investigate the effects of lipoproteins on periodontitis in mice. C57BL/6 male mice were randomly divided into three experimental groups: 1) Negative control group: animals received vehicle injection; 2) Positive control group: animals received injection of Escherichia coli lipopolysaccharide (LPS); 3) PAM2 group: animals received PAM2 injection. All the injections were performed bilaterally every other day into the palatal mucosa between first and second molars. After twenty-four days, the animals were euthanized to assess alveolar bone volume (micro-CT), cellular and extracellular composition in the gingiva (stereometric analysis), and osteoclast numbers (TRAP staining). Treatment with either PAM2 or LPS induced gingival inflammation, as demonstrated by increased infiltration of inflammatory cells and enhanced angiogenesis, associated with a smaller number of fibroblasts and decreased extracellular matrix. Importantly, treatment not only with LPS but also with PAM2 resulted in a larger number of TRAP+ multinucleated osteoclasts and significant loss of alveolar bone. Collectively, our data demonstrate that PAM2 can induce gingival inflammation and bone loss in mice, broadening the avenues of investigation into the role of lipoproteins in the pathogenesis of periodontal disease.
       
  • Erratum: Does low-cost GIC have the same survival rate as high-viscosity
           GIC in atraumatic restorative treatments' A RCT. Braz Oral Res.
           2019;33:e125.

    • Abstract: Lipoproteins are important bacterial immunostimulating molecules capable of inducing receptor activator of nuclear factor-κB (RANKL) and osteoclast formation in vitro and in vivo . Although these molecules are present in periodontopathogenic bacteria, their role in periodontitis is not known. In this study, we used Pam2CSK4 (PAM2), a synthetic molecule that mimics bacterial lipoprotein, to investigate the effects of lipoproteins on periodontitis in mice. C57BL/6 male mice were randomly divided into three experimental groups: 1) Negative control group: animals received vehicle injection; 2) Positive control group: animals received injection of Escherichia coli lipopolysaccharide (LPS); 3) PAM2 group: animals received PAM2 injection. All the injections were performed bilaterally every other day into the palatal mucosa between first and second molars. After twenty-four days, the animals were euthanized to assess alveolar bone volume (micro-CT), cellular and extracellular composition in the gingiva (stereometric analysis), and osteoclast numbers (TRAP staining). Treatment with either PAM2 or LPS induced gingival inflammation, as demonstrated by increased infiltration of inflammatory cells and enhanced angiogenesis, associated with a smaller number of fibroblasts and decreased extracellular matrix. Importantly, treatment not only with LPS but also with PAM2 resulted in a larger number of TRAP+ multinucleated osteoclasts and significant loss of alveolar bone. Collectively, our data demonstrate that PAM2 can induce gingival inflammation and bone loss in mice, broadening the avenues of investigation into the role of lipoproteins in the pathogenesis of periodontal disease.
       
 
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