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Publisher: SciELO   (Total: 789 journals)

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ABCD. Arquivos Brasileiros de Cirurgia Digestiva     Open Access   (Followers: 4)
ACIMED     Open Access   (SJR: 0.11, h-index: 4)
Acta Amazonica     Open Access   (Followers: 3, SJR: 0.319, h-index: 13)
Acta Bioethica     Open Access   (Followers: 2, SJR: 0.119, h-index: 3)
Acta Bioquimica Clinica Latinoamericana     Open Access   (Followers: 1, SJR: 0.134, h-index: 7)
Acta Botanica Brasilica     Open Access   (Followers: 2, SJR: 0.403, h-index: 17)
Acta botánica mexicana     Open Access   (SJR: 0.212, h-index: 4)
Acta Cirurgica Brasileira     Open Access   (SJR: 0.271, h-index: 14)
Acta Limnologica Brasiliensia     Open Access   (Followers: 1, SJR: 0.204, h-index: 2)
Acta Literaria     Open Access   (Followers: 2, SJR: 0.1, h-index: 2)
Acta Médica Costarricense     Open Access  
Acta Medica Peruana     Open Access   (Followers: 2)
Acta Neurológica Colombiana     Open Access   (Followers: 1)
Acta Odontológica Latinoamericana     Open Access  
Acta Ortopédica Brasileira     Open Access   (Followers: 2, SJR: 0.159, h-index: 9)
Acta Paulista de Enfermagem     Open Access   (Followers: 1, SJR: 0.34, h-index: 12)
Acta Pediátrica Costarricense     Open Access   (Followers: 1)
Acta Scientiarum. Agronomy     Open Access   (Followers: 3, SJR: 0.65, h-index: 11)
Acta Toxicológica Argentina     Open Access  
Acta zoológica mexicana     Open Access  
Actualidades Biológicas     Open Access  
African Human Rights Law J.     Open Access   (Followers: 19)
African Natural History     Open Access   (Followers: 2)
Afro-Asia     Open Access  
Ágora - studies in psychoanalytic theory     Open Access   (Followers: 2, SJR: 0.1, h-index: 1)
Agricultura Tecnica     Open Access   (Followers: 6)
Agriscientia     Open Access  
Agrociencia     Open Access   (Followers: 2, SJR: 0.192, h-index: 13)
Agronomía Mesoamericana     Open Access   (Followers: 1)
Aisthesis     Open Access   (Followers: 1)
Ajayu Órgano de Difusión Científica del Departamento de Psicología UCBSP     Open Access  
Alea : Estudos Neolatinos     Open Access   (Followers: 1, SJR: 0.126, h-index: 2)
Alpha (Osorno)     Open Access  
Ambiente & sociedade     Open Access   (Followers: 2, SJR: 0.189, h-index: 5)
Ambiente Construído     Open Access   (Followers: 2)
América Latina en la historia económica     Open Access   (Followers: 1, SJR: 0.101, h-index: 1)
Anais Brasileiros de Dermatologia     Open Access   (Followers: 1, SJR: 0.456, h-index: 16)
Anais da Academia Brasileira de Ciências     Open Access   (Followers: 2, SJR: 0.344, h-index: 34)
Anais do Museu Paulista : História e Cultura Material     Open Access   (Followers: 1)
Anales de Medicina Interna     Open Access   (Followers: 1)
Anales del Instituto de la Patagonia     Open Access   (Followers: 2)
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1, SJR: 0.179, h-index: 15)
Análise Psicológica     Open Access  
Análise Social     Open Access  
Análisis filosófico     Open Access  
Analisis Politico     Open Access   (Followers: 3, SJR: 0.1, h-index: 2)
Andean geology     Open Access   (Followers: 5, SJR: 0.825, h-index: 22)
Angiologia e Cirurgia Vascular     Open Access  
Annali dell'Istituto Superiore di Sanità     Open Access   (SJR: 0.272, h-index: 25)
Anuario Colombiano de Historia Social y de la Cultura     Open Access   (Followers: 1)
Apuntes : Revista de Estudios sobre Patrimonio Cultural - J. of Cultural Heritage Studies     Open Access   (Followers: 3)
Archivos argentinos de pediatría     Open Access  
Archivos de cardiología de México     Open Access   (Followers: 1, SJR: 0.136, h-index: 11)
Archivos de Medicina Veterinaria     Open Access   (Followers: 1, SJR: 0.249, h-index: 13)
Archivos de Neurociencias     Open Access   (Followers: 2, SJR: 0.104, h-index: 4)
Archivos de Pediatria del Uruguay     Open Access   (Followers: 1)
Archivos de Zootecnia     Open Access   (Followers: 4, SJR: 0.231, h-index: 6)
Archivos Españoles de Urología     Open Access   (SJR: 0.228, h-index: 16)
Archivos Venezolanos de Farmacología y Terapéutica     Open Access   (Followers: 1, SJR: 0.102, h-index: 2)
Argos     Open Access   (Followers: 2, SJR: 0.1, h-index: 1)
ARQ     Open Access   (Followers: 5, SJR: 0.1, h-index: 1)
Arquitectura y Urbanismo     Open Access   (Followers: 1)
Arquivo Brasileiro de Medicina Veterinária e Zootecnia     Open Access   (Followers: 1, SJR: 0.292, h-index: 18)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 1, SJR: 0.33, h-index: 29)
Arquivos Brasileiros de Endocrinologia e Metabologia     Open Access   (SJR: 0.329, h-index: 26)
Arquivos Brasileiros de Oftalmologia     Open Access   (SJR: 0.298, h-index: 15)
Arquivos de Gastroenterologia     Open Access   (Followers: 1, SJR: 0.43, h-index: 18)
Arquivos de Medicina     Open Access  
Arquivos de Neuro-Psiquiatria     Open Access   (SJR: 0.357, h-index: 33)
Arquivos do Instituto Biológico     Open Access  
Arquivos Internacionais de Otorrinolaringologia     Open Access  
ARS     Open Access   (Followers: 1)
Atenea (Concepción)     Open Access   (Followers: 1, SJR: 0.1, h-index: 2)
Atmósfera     Open Access   (SJR: 0.346, h-index: 13)
Audiology - Communication Research     Open Access   (Followers: 5)
Avaliação : Revista da Avaliação da Educação Superior (Campinas)     Open Access  
Avances en Odontoestomatologia     Open Access   (SJR: 0.112, h-index: 4)
Avances en Periodoncia e Implantología Oral     Open Access   (Followers: 5)
Bakhtiniana : Revista de Estudos do Discurso     Open Access  
BAR. Brazilian Administration Review     Open Access   (Followers: 1, SJR: 0.165, h-index: 4)
Biocell     Open Access   (SJR: 0.228, h-index: 19)
Biota Neotropica     Open Access   (SJR: 0.437, h-index: 12)
Biotecnología Aplicada     Open Access  
Boletim de Ciências Geodésicas     Open Access   (SJR: 0.202, h-index: 4)
Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas     Open Access   (Followers: 1, SJR: 0.201, h-index: 2)
Boletin Chileno de Parasitologia     Open Access  
Boletín de Filología     Open Access  
Boletín de Historia Argentina y Americana Dr. Emilio Ravignani     Open Access   (Followers: 1)
Boletin de la Sociedad Argentina de Botanica     Open Access   (Followers: 1, SJR: 0.191, h-index: 3)
Boletín de la Sociedad Botánica de México     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Boletín de la Sociedad Geológica Mexicana     Open Access   (SJR: 0.206, h-index: 7)
Boletín del Museo Chileno de Arte Precolombino     Open Access   (Followers: 1)
Bosque     Open Access   (Followers: 1, SJR: 0.245, h-index: 7)
Bragantia     Open Access   (Followers: 2, SJR: 0.685, h-index: 18)
Brazilian Archives of Biology and Technology     Open Access   (Followers: 2, SJR: 0.237, h-index: 24)
Brazilian Dental J.     Open Access   (Followers: 2, SJR: 0.433, h-index: 28)
Brazilian J. of Biology     Open Access   (Followers: 3, SJR: 0.436, h-index: 30)
Brazilian J. of Chemical Engineering     Open Access   (Followers: 3, SJR: 0.437, h-index: 25)
Brazilian J. of Food Technology     Open Access   (Followers: 4)

        1 2 3 4 5 6 7 8 | Last

Journal Cover   Brazilian Journal of Medical and Biological Research
  [SJR: 0.431]   [H-I: 62]   Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0100-879X - ISSN (Online) 1414-431X
   Published by SciELO Homepage  [789 journals]
  • CTLA4 enhances the osteogenic differentiation of allogeneic human
           mesenchymal stem cells in a model of immune activation

    • Abstract: Allogeneic mesenchymal stem cells (allo-MSCs) have recently garnered increasing interest for their broad clinical therapy applications. Despite this, many studies have shown that allo-MSCs are associated with a high rate of graft rejection unless immunosuppressive therapy is administered to control allo-immune responses. Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) is a co-inhibitory molecule expressed on T cells that mediates the inhibition of T-cell function. Here, we investigated the osteogenic differentiation potency of allo-MSCs in an activated immune system that mimics the in vivo allo-MSC grafting microenvironment and explored the immunomodulatory role of the helper T cell receptor CTLA4 in this process. We found that MSC osteogenic differentiation was inhibited in the presence of the activated immune response and that overexpression of CTLA4 in allo-MSCs suppressed the immune response and promoted osteogenic differentiation. Our results support the application of CTLA4-overexpressing allo-MSCs in bone tissue engineering.
       
  • Fat gain with physical detraining is correlated with increased glucose
           transport and oxidation in periepididymal white adipose tissue in rats

    • Abstract: As it is a common observation that obesity tends to occur after discontinuation of exercise, we investigated how white adipocytes isolated from the periepididymal fat of animals with interrupted physical training transport and oxidize glucose, and whether these adaptations support the weight regain seen after 4 weeks of physical detraining. Male Wistar rats (45 days old, weighing 200 g) were divided into two groups (n=10): group D (detrained), trained for 8 weeks and detrained for 4 weeks; and group S (sedentary). The physical exercise was carried out on a treadmill for 60 min/day, 5 days/week for 8 weeks, at 50-60% of the maximum running capacity. After the training protocol, adipocytes isolated from the periepididymal adipose tissue were submitted to glucose uptake and oxidation tests. Adipocytes from detrained animals increased their glucose uptake capacity by 18.5% compared with those from sedentary animals (P<0.05). The same cells also showed a greater glucose oxidation capacity in response to insulin stimulation (34.55%) compared with those from the S group (P<0.05). We hypothesize that, owing to the more intense glucose entrance into adipose cells from detrained rats, more substrate became available for triacylglycerol synthesis. Furthermore, this increased glucose oxidation rate allowed an increase in energy supply for triacylglycerol synthesis. Thus, physical detraining might play a role as a possible obesogenic factor for increasing glucose uptake and oxidation by adipocytes.
       
  • Treatment with 1,25(OH)2D3 induced HDAC2 expression
           and reduced NF-κB p65 expression in a rat model of OVA-induced asthma
           

    • Abstract: Recent evidence indicates that a deficiency of 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) may influence asthma pathogenesis; however, its roles in regulating specific molecular transcription mechanisms remain unclear. We aimed to investigate the effect of 1,25(OH)2D3 on the expression and enzyme activity of histone deacetylase 2 (HDAC2) and its synergistic effects with dexamethasone (Dx) in the inhibition of inflammatory cytokine secretion in a rat asthma model. Healthy Wistar rats were randomly divided into 6 groups: control, asthma, 1,25(OH)2D3 pretreatment, 1,25(OH)2D3 treatment, Dx treatment, and Dx and 1,25(OH)2D3 treatment. Pulmonary inflammation was induced by ovalbumin (OVA) sensitization and challenge (OVA/OVA). Inflammatory cells and cytokines in the bronchoalveolar lavage (BAL) fluid and histological changes in lung tissue were examined. Nuclear factor kappa B (NF-κB) p65 and HDAC2 expression levels were assessed with Western blot analyses and quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR). Enzyme activity measurements and immunohistochemical detection of HDAC2 were also performed. Our data demonstrated that 1,25(OH)2D3 reduced the airway inflammatory response and the level of inflammatory cytokines in BAL. Although NF-κB p65 expression was attenuated in the pretreatment and treatment groups, the expression and enzyme activity of HDAC2 were increased. In addition, 1,25(OH)2D3 and Dx had synergistic effects on the suppression of total cell infusion, cytokine release, and NF-κB p65 expression, and they also increased HDAC2 expression and activity in OVA/OVA rats. Collectively, our results indicated that 1,25(OH)2D3 might be useful as a novel HDAC2 activator in the treatment of asthma.
       
  • The effects of 6-gingerol on proliferation, differentiation, and
           maturation of osteoblast-like MG-63 cells

    • Abstract: We investigated whether 6-gingerol affects the maturation and proliferation of osteoblast-like MG63 cells in vitro. Osteoblast-like MG63 cells were treated with 6-gingerol under control conditions, and experimental inflammation was induced by tumor necrosis factor-α (TNF-α). Expression of different osteogenic markers and cytokines was analyzed by real-time PCR, Western blotting, and enzyme-linked immunosorbent assay. In addition, alkaline phosphatase (ALP) enzyme activity and biomineralization as markers for differentiation were measured. Treatment with 6-gingerol resulted in insignificant effects on the proliferation rate. 6-Gingerol induced the differentiation of osteoblast-like cells with increased transcription levels of osteogenic markers, upregulated ALP enzyme activity, and enhanced mineralized nodule formation. Stimulation with TNF-α led to enhanced interleukin-6 and nuclear factor-κB expression and downregulated markers of osteoblastic differentiation. 6-Gingerol reduced the degree of inflammation in TNF-α-treated MG-63 cells. In conclusion, 6-gingerol stimulated osteoblast differentiation in normal physiological and inflammatory settings, and therefore, 6-gingerol represents a promising agent for treating osteoporosis or bone inflammation.
       
  • Accuracy of dose planning for prostate radiotherapy in the presence of
           metallic implants evaluated by electron spin resonance dosimetry

    • Abstract: Radiotherapy is one of the main approaches to cure prostate cancer, and its success depends on the accuracy of dose planning. A complicating factor is the presence of a metallic prosthesis in the femur and pelvis, which is becoming more common in elderly populations. The goal of this work was to perform dose measurements to check the accuracy of radiotherapy treatment planning under these complicated conditions. To accomplish this, a scale phantom of an adult pelvic region was used with alanine dosimeters inserted in the prostate region. This phantom was irradiated according to the planned treatment under the following three conditions: with two metallic prostheses in the region of the femur head, with only one prosthesis, and without any prostheses. The combined relative standard uncertainty of dose measurement by electron spin resonance (ESR)/alanine was 5.05%, whereas the combined relative standard uncertainty of the applied dose was 3.35%, resulting in a combined relative standard uncertainty of the whole process of 6.06%. The ESR dosimetry indicated that there was no difference (P>0.05, ANOVA) in dosage between the planned dose and treatments. The results are in the range of the planned dose, within the combined relative uncertainty, demonstrating that the treatment-planning system compensates for the effects caused by the presence of femur and hip metal prostheses.
       
  • Yeast CUP1 protects HeLa cells against copper-induced stress

    • Abstract: As an essential trace element, copper can be toxic in mammalian cells when present in excess. Metallothioneins (MTs) are small, cysteine-rich proteins that avidly bind copper and thus play an important role in detoxification. Yeast CUP1 is a member of the MT gene family. The aim of this study was to determine whether yeast CUP1 could bind copper effectively and protect cells against copper stress. In this study, CUP1 expression was determined by quantitative real-time PCR, and copper content was detected by inductively coupled plasma mass spectrometry. Production of intracellular reactive oxygen species (ROS) was evaluated using the 2',7'-dichlorofluorescein-diacetate (DCFH-DA) assay. Cellular viability was detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and the cell cycle distribution of CUP1 was analyzed by fluorescence-activated cell sorting. The data indicated that overexpression of yeast CUP1 in HeLa cells played a protective role against copper-induced stress, leading to increased cellular viability (P<0.05) and decreased ROS production (P<0.05). It was also observed that overexpression of yeast CUP1 reduced the percentage of G1 cells and increased the percentage of S cells, which suggested that it contributed to cell viability. We found that overexpression of yeast CUP1 protected HeLa cells against copper stress. These results offer useful data to elucidate the mechanism of the MT gene on copper metabolism in mammalian cells.
       
  • Hydrogen sulfide in posthemorrhagic shock mesenteric lymph drainage
           alleviates kidney injury in rats

    • Abstract: Posthemorrhagic shock mesenteric lymph (PHSML) is a key factor in multiple organ injury following hemorrhagic shock. We investigated the role of hydrogen sulfide (H2S) in PHSML drainage in alleviating acute kidney injury (AKI) by administering D,L-propargylglycine (PPG) and sodium hydrosulfide hydrate (NaHS) to 12 specific pathogen-free male Wistar rats with PHSML drainage. A hemorrhagic shock model was established in 4 experimental groups: shock, shock+drainage, shock+drainage+PPG (45 mg/kg, 0.5 h prehemorrhage), and shock+drainage+NaHS (28 µmol/kg, 0.5 h prehemorrhage). Fluid resuscitation was performed after 1 h of hypotension, and PHMSL was drained in the last three groups for 3 h after resuscitation. Renal function and histomorphology were assessed along with levels of H2S, cystathionine-γ-lyase (CSE), Toll-like receptor 4 (TLR4), interleukin (IL)-10, IL-12, and tumor necrosis factor (TNF)-α in renal tissue. Hemorrhagic shock induced AKI with increased urea and creatinine levels in plasma and higher H2S, CSE, TLR4, IL-10, IL-12, and TNF-α levels in renal tissue. PHSML drainage significantly reduced urea, creatinine, H2S, CSE, and TNF-α but not TLR4, IL-10, or IL-12. PPG decreased creatinine, H2S, IL-10, and TNF-α levels, but this effect was reversed by NaHS administration. In conclusion, PHSML drainage alleviated AKI following hemorrhagic shock by preventing increases in H2S and H2S-mediated inflammation.
       
  • The consensus sequence of FAMLF alternative splice variants is
           overexpressed in undifferentiated hematopoietic cells

    • Abstract: The familial acute myeloid leukemia related factor gene (FAMLF) was previously identified from a familial AML subtractive cDNA library and shown to undergo alternative splicing. This study used real-time quantitative PCR to investigate the expression of the FAMLF alternative-splicing transcript consensus sequence (FAMLF-CS) in peripheral blood mononuclear cells (PBMCs) from 119 patients with de novo acute leukemia (AL) and 104 healthy controls, as well as in CD34+ cells from 12 AL patients and 10 healthy donors. A 429-bp fragment from a novel splicing variant of FAMLF was obtained, and a 363-bp consensus sequence was targeted to quantify total FAMLF expression. Kruskal-Wallis, Nemenyi, Spearman's correlation, and Mann-Whitney U-tests were used to analyze the data. FAMLF-CS expression in PBMCs from AL patients and CD34+ cells from AL patients and controls was significantly higher than in control PBMCs (P<0.0001). Moreover, FAMLF-CS expression in PBMCs from the AML group was positively correlated with red blood cell count (rs =0.317, P=0.006), hemoglobin levels (rs =0.210, P=0.049), and percentage of peripheral blood blasts (rs =0.256, P=0.027), but inversely correlated with hemoglobin levels in the control group (rs =–0.391, P<0.0001). AML patients with high CD34+ expression showed significantly higher FAMLF-CS expression than those with low CD34+ expression (P=0.041). Our results showed that FAMLF is highly expressed in both normal and malignant immature hematopoietic cells, but that expression is lower in normal mature PBMCs.
       
  • IGF2, LEPR, POMC, PPARG, and PPARGC1
           gene variants are associated with obesity-related risk phenotypes in
           Brazilian children and adolescents

    • Abstract: Association studies of genetic variants and obesity and/or obesity-related risk factors have yielded contradictory results. The aim of the present study was to determine the possible association of five single-nucleotide polymorphisms (SNPs) located in the IGF2, LEPR, POMC, PPARG, and PPARGC1 genes with obesity or obesity-related risk phenotypes. This case-control study assessed overweight (n=192) and normal-weight (n=211) children and adolescents. The SNPs were analyzed using minisequencing assays, and variables and genotype distributions between the groups were compared using one-way analysis of variance and Pearson's chi-square or Fisher's exact tests. Logistic regression analysis adjusted for age and gender was used to calculate the odds ratios (ORs) for selected phenotype risks in each group. No difference in SNP distribution was observed between groups. In children, POMC rs28932472(C) was associated with lower diastolic blood pressure (P=0.001), higher low-density lipoprotein (LDL) cholesterol (P=0.014), and higher risk in overweight children of altered total cholesterol (OR=7.35, P=0.006). In adolescents, IGF2 rs680(A) was associated with higher glucose (P=0.012) and higher risk in overweight adolescents for altered insulin (OR=10.08, P=0.005) and homeostasis model of insulin resistance (HOMA-IR) (OR=6.34, P=0.010). PPARG rs1801282(G) conferred a higher risk of altered insulin (OR=12.31, P=0.003), and HOMA-IR (OR=7.47, P=0.005) in overweight adolescents. PARGC1 rs8192678(A) was associated with higher triacylglycerols (P=0.005), and LEPR rs1137101(A) was marginally associated with higher LDL cholesterol (P=0.017). LEPR rs1137101(A) conferred higher risk for altered insulin, and HOMA-IR in overweight adolescents. The associations observed in this population suggested increased risk for cardiovascular diseases and/or type 2 diabetes later in life for individuals carrying these alleles.
       
  • DNA methylation patterns of candidate genes regulated by thymine DNA
           glycosylase in patients with TP53 germline mutations

    • Abstract: Li-Fraumeni syndrome (LFS) is a rare, autosomal dominant, hereditary cancer predisposition disorder. In Brazil, the p.R337H TP53 founder mutation causes the variant form of LFS, Li-Fraumeni-like syndrome. The occurrence of cancer and age of disease onset are known to vary, even in patients carrying the same mutation, and several mechanisms such as genetic and epigenetic alterations may be involved in this variability. However, the extent of involvement of such events has not been clarified. It is well established that p53 regulates several pathways, including the thymine DNA glycosylase (TDG) pathway, which regulates the DNA methylation of several genes. This study aimed to identify the DNA methylation pattern of genes potentially related to the TDG pathway (CDKN2A, FOXA1, HOXD8, OCT4, SOX2, and SOX17) in 30 patients with germline TP53 mutations, 10 patients with wild-type TP53, and 10 healthy individuals. We also evaluated TDG expression in patients with adrenocortical tumors (ADR) with and without the p.R337H TP53 mutation. Gene methylation patterns of peripheral blood DNA samples assessed by pyrosequencing revealed no significant differences between the three groups. However, increased TDG expression was observed by quantitative reverse transcription PCR in p.R337H carriers with ADR. Considering the rarity of this phenotype and the relevance of these findings, further studies using a larger sample set are necessary to confirm our results.
       
  • High prevalence of methicillin resistance and PVL genes among
           Staphylococcus aureus isolates from the nares and skin lesions of
           pediatric patients with atopic dermatitis

    • Abstract: Staphylococcus aureus is highly prevalent among patients with atopic dermatitis (AD), and this pathogen may trigger and aggravate AD lesions. The aim of this study was to determine the prevalence of S. aureus in the nares of pediatric subjects and verify the phenotypic and molecular characteristics of the isolates in pediatric patients with AD. Isolates were tested for antimicrobial susceptibility, SCCmec typing, and Panton-Valentine Leukocidin (PVL) genes. Lineages were determined by pulsed-field gel electrophoresis and multilocus sequence typing (MLST). AD severity was assessed with the Scoring Atopic Dermatitis (SCORAD) index. Among 106 patients, 90 (85%) presented S. aureus isolates in their nares, and 8 also presented the pathogen in their skin infections. Two patients had two positive lesions, making a total of 10 S. aureus isolates from skin infections. Methicillin-resistant S. aureus (MRSA) was detected in 24 (26.6%) patients, and PVL genes were identified in 21 (23.3%), including 6 (75%) of the 8 patients with skin lesions but mainly in patients with severe and moderate SCORAD values (P=0.0095). All 24 MRSA isolates were susceptible to trimethoprim/sulfamethoxazole, while 8 isolates had a minimum inhibitory concentration (MIC) to mupirocin >1024 μg/mL. High lineage diversity was found among the isolates including USA1100/ST30, USA400/ST1, USA800/ST5, ST83, ST188, ST718, ST1635, and ST2791. There was a high prevalence of MRSA and PVL genes among the isolates recovered in this study. PVL genes were found mostly among patients with severe and moderate SCORAD values. These findings can help clinicians improve the therapies and strategies for the management of pediatric patients with AD.
       
  • Evaluation of a father and son with atypical chronic myeloid leukemia with
           SETBP1 mutations and a review of the literature

    • Abstract: We report the case of a father and son diagnosed with atypical chronic myeloid leukemia (aCML). Both patients harbored SETBP1 mutations, which are present in 24.3% of aCML patients. Moreover, both shared the variant encoding p.Pro737His, but the aCML severity was greater in the son because of the presence of two other missense mutations causing p.Asp868Asn and p.Ser885Arg alterations. SETBP1 mutations may be associated with an adverse prognosis, so their detection would help in the diagnosis of aCML and the determination of a patient's prognosis.
       
 
 
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