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Publisher: SciELO   (Total: 715 journals)

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Showing 1 - 200 of 715 Journals sorted alphabetically
ABCD. Arquivos Brasileiros de Cirurgia Digestiva     Open Access   (Followers: 2, SJR: 0.207, CiteScore: 1)
ACIMED     Open Access   (Followers: 1)
Acta Agronómica     Open Access  
Acta Amazonica     Open Access   (Followers: 5, SJR: 0.36, CiteScore: 1)
Acta Bioethica     Open Access   (SJR: 0.196, CiteScore: 0)
Acta Botanica Brasilica     Open Access   (Followers: 3, SJR: 0.325, CiteScore: 1)
Acta botánica mexicana     Open Access   (Followers: 1, SJR: 0.212, CiteScore: 0)
Acta Cirurgica Brasileira     Open Access   (SJR: 0.395, CiteScore: 1)
Acta Limnologica Brasiliensia     Open Access   (Followers: 3, SJR: 0.28, CiteScore: 1)
Acta Literaria     Open Access   (Followers: 3, SJR: 0.1, CiteScore: 0)
Acta Medica Colombiana     Open Access   (Followers: 1)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Neurológica Colombiana     Open Access   (Followers: 2)
Acta Ortopédica Brasileira     Open Access   (Followers: 1, SJR: 0.343, CiteScore: 1)
Acta Paulista de Enfermagem     Open Access   (Followers: 2, SJR: 0.275, CiteScore: 1)
Acta Pediátrica Costarricense     Open Access   (Followers: 1)
Acta Scientiarum. Agronomy     Open Access   (Followers: 6, SJR: 0.431, CiteScore: 1)
Acta zoológica mexicana     Open Access  
Actualidades Biológicas     Open Access   (Followers: 1)
African Human Rights Law J.     Open Access   (Followers: 18)
African Natural History     Open Access   (Followers: 2, SJR: 0.198, CiteScore: 1)
Afro-Asia     Open Access  
Ágora - studies in psychoanalytic theory     Open Access   (Followers: 3, SJR: 0.132, CiteScore: 0)
Agricultura Tecnica     Open Access   (Followers: 5)
Agrociencia     Open Access   (Followers: 1, SJR: 0.2, CiteScore: 0)
Agrociencia Uruguay     Open Access  
Agronomía Mesoamericana     Open Access  
Aisthesis     Open Access   (Followers: 7, SJR: 0.106, CiteScore: 0)
Alea : Estudos Neolatinos     Open Access   (Followers: 2, SJR: 0.1, CiteScore: 0)
Alfa : Revista de Linguística     Open Access  
Alpha (Osorno)     Open Access   (SJR: 0.138, CiteScore: 0)
Ambiente & sociedade     Open Access   (Followers: 3, SJR: 0.235, CiteScore: 0)
Ambiente & Agua : An Interdisciplinary J. of Applied Science     Open Access   (Followers: 1, SJR: 0.263, CiteScore: 1)
Ambiente Construído     Open Access   (Followers: 1)
América Latina en la historia económica     Open Access   (Followers: 3, SJR: 0.134, CiteScore: 0)
Anais Brasileiros de Dermatologia     Open Access   (Followers: 3, SJR: 0.52, CiteScore: 1)
Anais da Academia Brasileira de Ciências     Open Access   (Followers: 2, SJR: 0.418, CiteScore: 1)
Anais do Museu Paulista : História e Cultura Material     Open Access  
Anales de Medicina Interna     Open Access   (Followers: 1)
Anales del Instituto de la Patagonia     Open Access  
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1, SJR: 0.157, CiteScore: 0)
Análise Psicológica     Open Access   (Followers: 1, SJR: 0.16, CiteScore: 0)
Análise Social     Open Access   (Followers: 2, SJR: 0.16, CiteScore: 0)
Andean geology     Open Access   (Followers: 9, SJR: 0.674, CiteScore: 1)
Antipoda. Revista de Antropología y Arqueología     Open Access   (Followers: 5, SJR: 0.135, CiteScore: 0)
Anuario Colombiano de Historia Social y de la Cultura     Open Access   (SJR: 0.1, CiteScore: 0)
Anuario de Historia Regional y de las Fronteras     Open Access  
Apuntes : Revista de Estudios sobre Patrimonio Cultural - J. of Cultural Heritage Studies     Open Access   (Followers: 6)
Archivos de Medicina Veterinaria     Open Access   (Followers: 1, SJR: 0.194, CiteScore: 0)
Archivos de Neurociencias     Open Access   (Followers: 3, SJR: 0.111, CiteScore: 0)
Archivos de Pediatria del Uruguay     Open Access   (Followers: 3)
Archivos de Zootecnia     Open Access   (Followers: 1, SJR: 0.202, CiteScore: 0)
Archivos Españoles de Urología     Open Access   (SJR: 0.178, CiteScore: 0)
Argos     Open Access   (Followers: 1)
ARQ     Open Access   (Followers: 5, SJR: 0.113, CiteScore: 0)
Arquitectura y Urbanismo     Open Access   (Followers: 3)
Arquivo Brasileiro de Medicina Veterinária e Zootecnia     Open Access   (SJR: 0.248, CiteScore: 0)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 1, SJR: 0.381, CiteScore: 1)
Arquivos Brasileiros de Endocrinologia e Metabologia     Open Access  
Arquivos Brasileiros de Oftalmologia     Open Access   (SJR: 0.518, CiteScore: 1)
Arquivos de Gastroenterologia     Open Access   (Followers: 1, SJR: 0.396, CiteScore: 1)
Arquivos de Medicina     Open Access  
Arquivos de Neuro-Psiquiatria     Open Access   (SJR: 0.448, CiteScore: 1)
Arquivos do Instituto Biológico     Open Access   (Followers: 1)
Arquivos Internacionais de Otorrinolaringologia     Open Access  
ARS     Open Access   (Followers: 3)
Atenea (Concepción)     Open Access   (SJR: 0.112, CiteScore: 0)
Atmósfera     Open Access   (Followers: 2, SJR: 0.449, CiteScore: 1)
Audiology - Communication Research     Open Access   (Followers: 9)
Avaliação : Revista da Avaliação da Educação Superior (Campinas)     Open Access  
Avances en Odontoestomatologia     Open Access   (SJR: 0.105, CiteScore: 0)
Avances en Periodoncia e Implantología Oral     Open Access   (Followers: 1)
Bakhtiniana : Revista de Estudos do Discurso     Open Access   (SJR: 0.103, CiteScore: 0)
BAR. Brazilian Administration Review     Open Access   (Followers: 1, SJR: 0.137, CiteScore: 0)
Biota Neotropica     Open Access   (SJR: 0.381, CiteScore: 1)
Biotecnología Aplicada     Open Access   (SJR: 0.146, CiteScore: 0)
Biotecnología en el Sector Agropecuario y Agroindustrial     Open Access  
Boletim de Ciências Geodésicas     Open Access   (SJR: 0.188, CiteScore: 0)
Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas     Open Access   (Followers: 1, SJR: 0.238, CiteScore: 0)
Boletin Chileno de Parasitologia     Open Access  
Boletín de Filología     Open Access  
Boletín de la Sociedad Botánica de México     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Boletín de la Sociedad Geológica Mexicana     Open Access   (SJR: 0.291, CiteScore: 1)
Boletín del Museo Chileno de Arte Precolombino     Open Access   (Followers: 1, SJR: 0.233, CiteScore: 0)
Bosque     Open Access   (Followers: 2, SJR: 0.29, CiteScore: 1)
Bragantia     Open Access   (Followers: 2, SJR: 0.555, CiteScore: 1)
Brazilian Archives of Biology and Technology     Open Access   (Followers: 3, SJR: 0.281, CiteScore: 1)
Brazilian Dental J.     Open Access   (Followers: 3, SJR: 0.476, CiteScore: 1)
Brazilian J. of Biology     Open Access   (Followers: 3, SJR: 0.523, CiteScore: 1)
Brazilian J. of Chemical Engineering     Open Access   (Followers: 4, SJR: 0.395, CiteScore: 1)
Brazilian J. of Food Technology     Open Access   (Followers: 3, SJR: 0.206, CiteScore: 0)
Brazilian J. of Medical and Biological Research     Open Access   (SJR: 0.611, CiteScore: 2)
Brazilian J. of Microbiology     Open Access   (Followers: 4, SJR: 0.63, CiteScore: 2)
Brazilian J. of Oceanography     Open Access   (Followers: 1, SJR: 0.425, CiteScore: 1)
Brazilian J. of Oral Sciences     Open Access   (Followers: 2, SJR: 0.131, CiteScore: 0)
Brazilian J. of Physical Therapy     Open Access   (SJR: 0.802, CiteScore: 2)
Brazilian J. of Plant Physiology     Open Access   (Followers: 3, SJR: 1.178, CiteScore: 3)
Brazilian J. of Veterinary Research and Animal Science     Open Access   (Followers: 8, SJR: 0.225, CiteScore: 0)
Brazilian Oral Research     Open Access  
Brazilian Political Science Review     Open Access   (Followers: 2)
Caderno CRH     Open Access   (Followers: 3, SJR: 0.233, CiteScore: 0)
Caderno de Estudos     Open Access  
Cadernos CEDES     Open Access   (Followers: 1, SJR: 0.119, CiteScore: 0)
Cadernos de Pesquisa     Open Access   (Followers: 2, SJR: 0.183, CiteScore: 0)
Cadernos de Saúde Pública     Open Access   (Followers: 1, SJR: 0.568, CiteScore: 1)
Cadernos de Tradução     Open Access  
Cadernos Metrópole     Open Access   (Followers: 1)
Cadernos Nietzsche     Open Access  
Cadernos Pagu     Open Access   (SJR: 0.356, CiteScore: 0)
Cadernos Saúde Coletiva     Open Access   (Followers: 1)
Caldasia     Open Access   (SJR: 0.195, CiteScore: 0)
Calidad en la educación     Open Access   (Followers: 1)
Cerâmica     Open Access   (Followers: 5, SJR: 0.186, CiteScore: 0)
CES Medicina     Open Access  
Chilean J. of Agricultural Research     Open Access   (Followers: 1, SJR: 0.377, CiteScore: 1)
Chungara (Arica) - Revista de Antropologia Chilena     Open Access   (Followers: 1, SJR: 0.565, CiteScore: 1)
Ciência & Educação (Bauru)     Open Access  
Ciência & Saúde Coletiva     Open Access   (Followers: 2, SJR: 0.566, CiteScore: 1)
Ciência Animal Brasileira     Open Access   (Followers: 1, SJR: 0.216, CiteScore: 0)
Ciência da Informação     Open Access   (Followers: 1, SJR: 0.121, CiteScore: 0)
Ciencia del suelo     Open Access   (Followers: 2)
Ciência e Agrotecnologia     Open Access   (SJR: 0.383, CiteScore: 1)
Ciencia e Cultura     Open Access   (Followers: 1)
Ciencia e investigación agraria     Open Access   (Followers: 1, SJR: 0.211, CiteScore: 0)
Ciencia forestal en México     Open Access  
Ciência Rural     Open Access   (Followers: 2, SJR: 0.337, CiteScore: 1)
Ciencia y Enfermeria - Revista Iberoamericana de Investigacion     Open Access   (Followers: 3, SJR: 0.158, CiteScore: 0)
Ciencias Marinas     Open Access   (Followers: 2, SJR: 0.414, CiteScore: 1)
Ciencias Psicológicas     Open Access  
Cirugia Plastica Ibero-Latinoamericana     Open Access   (SJR: 0.166, CiteScore: 0)
CLEI Electronic J.     Open Access  
Clínica y Salud     Open Access   (SJR: 0.173, CiteScore: 0)
Clinics     Open Access   (SJR: 0.536, CiteScore: 1)
CoDAS     Open Access   (SJR: 0.267, CiteScore: 0)
Computación y Sistemas     Open Access   (SJR: 0.226, CiteScore: 1)
Comuni@cción     Open Access  
Comunicación y sociedad     Open Access   (Followers: 2, SJR: 0.327, CiteScore: 0)
Contaduría y Administración     Open Access   (SJR: 0.219, CiteScore: 0)
Contexto Internacional     Open Access  
Convergencia     Open Access   (Followers: 3, SJR: 0.196, CiteScore: 0)
Correo Científico Médico     Open Access  
Corrosão e Protecção de Materiais     Open Access  
Crop Breeding and Applied Biotechnology     Open Access   (Followers: 3, SJR: 0.609, CiteScore: 1)
Cuadernos de Economía     Open Access   (Followers: 2)
Cuadernos de Economia - Latin American J. of Economics     Open Access   (Followers: 3)
Cuadernos de Historia     Open Access   (Followers: 1)
Cuadernos de Historia de la Salud Publica     Open Access  
Cuadernos de Medicina Forense     Open Access   (Followers: 2, SJR: 0.1, CiteScore: 0)
Cuadernos.info     Open Access   (SJR: 0.38, CiteScore: 0)
Cubo. A Mathematical J.     Open Access  
Cuicuilco     Open Access   (Followers: 1)
Cultivos Tropicales     Open Access   (Followers: 1)
Culturales     Open Access   (Followers: 3)
Dados - Revista de Ciências Sociais     Open Access   (SJR: 0.37, CiteScore: 0)
De Jure     Open Access   (Followers: 1)
DELTA : Documentação de Estudos em Lingüística Teórica e Aplicada     Open Access   (SJR: 0.133, CiteScore: 0)
Dementia & Neuropsychologia     Open Access   (Followers: 8, SJR: 0.205, CiteScore: 0)
Dental Press J. of Orthodontics     Open Access   (Followers: 2, SJR: 0.489, CiteScore: 1)
Desacatos     Open Access   (Followers: 1)
Desarrollo y Sociedad     Open Access   (Followers: 3, SJR: 0.109, CiteScore: 0)
Diálogo Andino - Revista de Historia, Geografía y Cultura Andina     Open Access   (SJR: 0.116, CiteScore: 0)
Diánoia     Open Access   (Followers: 1)
Dimensión Empresarial     Open Access  
Dynamis : Acta Hispanica ad Medicinae Scientiarumque Historiam Illustrandam     Open Access   (Followers: 2, SJR: 0.131, CiteScore: 0)
e-J. of Portuguese History     Open Access   (Followers: 2, SJR: 0.101, CiteScore: 0)
Eclética Química     Open Access   (Followers: 1)
Ecología en Bolivia     Open Access  
Economia Aplicada     Open Access   (SJR: 0.208, CiteScore: 0)
Economia e Sociedade     Open Access  
EconoQuantum     Open Access  
Educação & Sociedade     Open Access   (Followers: 3)
Educação e Pesquisa     Open Access   (Followers: 1, SJR: 0.163, CiteScore: 0)
Educação em Revista     Open Access  
Educación Matemática     Open Access  
Educación Médica     Open Access   (Followers: 1, SJR: 0.236, CiteScore: 0)
Educación Médica Superior     Open Access   (Followers: 1, SJR: 0.237, CiteScore: 0)
Educación y Educadores     Open Access  
Educar em Revista     Open Access  
EDUMECENTRO     Open Access  
En-Claves del pensamiento     Open Access   (Followers: 1, SJR: 0.194, CiteScore: 0)
Encuentros     Open Access  
Ene : Revista de Enfermería     Open Access  
Enfermería Global     Open Access   (Followers: 3, SJR: 0.165, CiteScore: 0)
Enfermería Nefrológica     Open Access   (Followers: 1, SJR: 0.198, CiteScore: 0)
Enfoques     Open Access  
Engenharia Agrícola     Open Access   (SJR: 0.305, CiteScore: 1)
Engenharia Sanitaria e Ambiental     Open Access   (SJR: 0.218, CiteScore: 0)
Ensaio Avaliação e Políticas Públicas em Educação     Open Access   (Followers: 1, SJR: 0.254, CiteScore: 0)
Entomologia y Vectores     Open Access   (Followers: 2)
Escritos de Psicología : Psychological Writings     Open Access   (Followers: 2)
Estudios Atacameños     Open Access   (Followers: 2, SJR: 0.446, CiteScore: 1)
Estudios Constitucionales     Open Access   (Followers: 5, SJR: 0.319, CiteScore: 0)
Estudios de Cultura Maya     Open Access   (Followers: 2, SJR: 0.272, CiteScore: 0)
Estudios de Economía     Open Access   (SJR: 0.121, CiteScore: 0)
Estudios de historia moderna y contemporánea de México     Open Access   (SJR: 0.101, CiteScore: 0)
Estudios Filologicos     Open Access   (SJR: 0.107, CiteScore: 0)
Estudios Fronterizos     Open Access   (Followers: 1)
Estudios internacionales     Open Access   (Followers: 5)
Estudios Pedagogicos (Valdivia)     Open Access   (Followers: 1, SJR: 0.338, CiteScore: 0)

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Journal Cover
Brazilian Journal of Medical and Biological Research
Journal Prestige (SJR): 0.611
Citation Impact (citeScore): 2
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0100-879X - ISSN (Online) 1414-431X
Published by SciELO Homepage  [715 journals]
  • Omphaloceles in combination with a self-made hemispherical cushion: a
           report of 12 cases

    • Abstract: The aim of this study was to discuss the curative effect of applying “capsule-reserved normal saline bag and self-made hemi-spherical cushion oppression” for treating giant omphaloceles. Twelve patients with giant omphaloceles who were admitted to our hospital between January 2008 and June 2016 were selected for treatment as follows: a capsule-reserved normal saline bag was used to promote the gradual return of the abdominal contents into the abdominal cavity in phase I, and a self-made hemi-spherical cushion was used for compression combined with a local dressing change in phase II to treat the giant omphaloceles without surgical treatment. All 12 patients in this group were cured, and after follow-up visits for >10 months, they had no abdominal infections, wound disruption, intestinal obstruction, or other complications, and their growth was normal. Two patients had abdominal hernias, and they recovered after herniorrhaphies. Giant omphaloceles in newborns were treated in stages, and in phase II, non-surgical treatment was applied, which was easily performed with a smaller wound, low cost, an obvious curative effect, and higher safety and effectiveness.
       
  • Transplantation of rat-derived microglial cells promotes functional
           recovery in a rat model of spinal cord injury

    • Abstract: This study evaluated the effect of microglia transplantation on neurological functional recovery in rats subjected to traumatic spinal cord injury (SCI). The rat model of SCI was established using a weight drop device. Forty SCI rats were randomly divided into the microglia group and the saline group. Then, rat-derived microglial cells or normal saline was injected into the injured site 7 days after surgery. The Basso-Beattie-Bresnahan (BBB) score, inclined plate test, and motor-evoked potentials (MEPs) were applied to assess the recovery of motor function. Hematoxylin and eosin (H&E) staining was used to assess the therapeutic effect. Microglia transplantation significantly improved BBB scores and functional scores at 2, 3, 4, 6, and 8 weeks after surgery compared to saline injection (P<0.05). Meanwhile, a prolonged MEP latency and decreased MEP amplitude were observed at 4 and 8 weeks in the microglia group (P<0.05). Histological analysis showed less damage and better prognosis in SCI rats of the microglia group. BrdU+ cell tracing experiments showed that microglia were recruited to the injured area of the spinal cord at 7 and 14 days after transplantation. The intensity of immunofluorescence was increased in CD68+ and OX42+ microglia at 2 days, 1 week, and 2 weeks, and then decreased at 3 and 4 weeks after transplantation in the microglia group. The transplantation of activated microglia played a key role in promoting the recovery of spinal cord function in a rat model of SCI.
       
  • Comparison of endoplasmic reticulum stress and mitochondrial biogenesis
           responses after 12 weeks of treadmill running and ladder climbing
           exercises in the cardiac muscle of middle-aged obese rats

    • Abstract: The purpose of the present study was to compare the influence of aerobic exercise (AE) lasting 12 weeks to that of resistance exercise (RE) of the same duration on endoplasmic reticulum (ER) stress and mitochondrial biogenesis in the cardiac muscle of middle-aged obese rats. Obesity was induced in thirty 50-week-old male Sprague Dawley rats over 6 weeks by administration of a high-fat diet. The rats were then subjected to treadmill-running (AE) and ladder-climbing (RE) exercises 3 times per week for 12 weeks. Rats in the AE group showed significantly lower increases in body weight and intraperitoneal fat than those in the sedentary control (SC) group (P<0.05). The 12-week exercise regimes resulted in a significant increase in expression of mitochondrial biogenesis markers and levels of peroxisome proliferator-activated receptor gamma coactivator 1α in the cardiac muscle (P<0.05). Phosphorylation of PKR-like ER kinase, an ER stress marker, decreased significantly (P<0.05) after the exercise training. Although a trend for decreased C/EBP homologous protein (CHOP) expression was observed in both exercise groups, only the AE group had a statistically significant decrease (P<0.05). Levels of GRP78, an ER stress marker that protects cardiac muscle, did not significantly differ among the groups. Although only the AE group decreased body weight and fat mass, the two exercise regimes had similar effects on cardiac muscle with the exception of CHOP. Therefore, we suggest that both AE, which results in weight loss, and high-intensity RE, though not accompanied by weight loss, protect obese cardiac muscle effectively.
       
  • Icariin reduces human colon carcinoma cell growth and metastasis by
           enhancing p53 activities

    • Abstract: Icariin has been reported to possess high anticancer activity. Colon carcinoma is one of the leading causes of cancer-related mortality worldwide. Here, the anticancer activity of icariin against HCT116 colon carcinoma cells and the possible underlying mechanism were studied. The trypan blue staining assay, wound healing assay, clonogenic assay, CCK-8 assay, and Annexin V-FITC/PI double staining method were carried out to determine the changes of HCT116 cell growth and migration. mRNA and protein expressions were determined by quantitative real-time PCR and western blot, respectively. Moreover, small interfering RNA (siRNA) plasmid was used to examine the role of p53 in icariin-induced apoptosis in HCT116 cells. Icariin significantly suppressed colon carcinoma HCT116 cells by decreasing migration and viability, and simultaneously promoting apoptosis. Icariin exerted the anti-tumor effect in a dose-dependent manner by up-regulating p53. During treatment of icariin, p-p53, p21, and Bax levels increased, and Bcl-2 level decreased. Short time treatment with icariin induced DNA damage in HCT116 cells. Furthermore, the cytotoxicity of icariin was decreased after p53 knockdown or by using caspase inhibitors. p53 was involved in activities of caspase-9 and caspase-3. Icariin repressed colon carcinoma cell line HCT116 by enhancing p53 expression and activating p53 functions possibly through Bcl-2/Bax imbalance and caspase-9 and -3 regulation. Icariin treatment also induced DNA damage in HCT116 cells.
       
  • Baicalein alleviates tubular-interstitial nephritis in vivo and in vitro
           by down-regulating NF-κB and MAPK pathways

    • Abstract: Tubular-interstitial nephritis (TIN) is characterized by tubular cell damage and inflammatory lesions of kidneys. Baicalein (BAI) is a flavonoid compound found in the roots of Scutellaria baicalensis Georgi. The present study was undertaken to explore the anti-inflammatory and anti-oxidative effects of BAI on TIN patients and a lipopolysaccharide (LPS)-induced TIN cell model. The expression levels of interleukin-6 (IL-6), IL-10, and tumor necrosis factor α in serum samples of TIN patients and culture supernatants of renal proximal tubular epithelial cells (RPTECs) were evaluated using enzyme-linked immunosorbent assay. Creatinine clearance was calculated using the Cockcroft-Gault equation. Activities of malondialdehyde, superoxide dismutase, and glutathione peroxidase were also determined. Viability and apoptosis of RPTECs were measured using MTT assay and Guava Nexin assay, respectively. qRT-PCR was performed to determine the expressions of Bax, Bcl-2, nuclear factor kappa B (IκBα), and p65. Protein levels of Bax, Bcl-2, IκBα, p65, c-Jun N-terminal kinase, extracellular regulated protein kinases, and p38 were analyzed using western blotting. We found that BAI reduced inflammation and oxidative stress in vivo and in vitro. Moreover, BAI alleviated the LPS-induced RPTECs viability inhibition and apoptosis enhancement, as well as nuclear factor kappa B (NF-κB), and mitogen-activated protein kinase (MAPK) activation. Phorbol ester, an activator of NF-κB, attenuated the effects of BAI on LPS-induced inflammatory cytokine expressions in RPTECs. In conclusion, BAI had anti-inflammatory and anti-oxidative effects on TIN patients and LPS-induced RPTECs by down-regulating NF-κB and MAPK pathways.
       
  • Adrenergic receptor β3 is involved in the memory
           consolidation process in mice

    • Abstract: Attention and emotion have a positive impact on memory formation, which is related to the activation of the noradrenergic system in the brain. The hippocampus and amygdala are fundamental structures in memory acquisition, which is modulated by noradrenaline through the noradrenergic receptors. Pharmacological studies suggest that memory acquisition depends on the action of both the β3 (β3-AR) and β2 (β2-AR) receptor subtypes. However, the use of animal models with specific knockout for the β3-AR receptor only (β3-ARKO) allows researchers to more accurately assess its role in memory formation processes. In the present study, we evaluated short- and long-term memory acquisition capacity in β3-ARKO mice and wild-type mice at approximately 60 days of age. The animals were submitted to the open field test, the elevated plus maze, object recognition, and social preference. The results showed that the absence of the β3-AR receptor caused no impairment in locomotion and did not cause anxious behavior, but it caused significant impairment of short- and long-term memory compared to wild-type animals. We also evaluated the expression of genes involved in memory consolidation. The mRNA levels for GLUT3, a glucose transporter expressed in the central nervous system, were significantly reduced in the amygdala, but not in the hippocampus of the β3-ARKO animals. Our results showed that β3-AR was involved in the process of acquisition of declarative memory, and its action may be due to the facilitation of glucose absorption in the amygdala.
       
  • Saquinavir plus methylprednisolone ameliorates experimental acute lung
           injury

    • Abstract: Glucocorticoid insensitivity is an important barrier to the treatment of several inflammatory diseases, including acute lung injury (ALI). Saquinavir (SQV) is an inhibitor of the human immunodeficiency virus protease, and the therapeutic effects of SQV in ALI accompanied with glucocorticoid insensitivity have not been previously investigated. In this study, the effects of SQV on lipopolysaccharide (LPS)-mediated injury in human pulmonary microvascular endothelial cells (HPMECs), human type I alveolar epithelial cells (AT I), and alveolar macrophages were determined. In addition, the effects of SQV on an LPS-induced ALI model with or without methylprednisolone (MPS) were studied. In LPS-stimulated HPMECs, SQV treatment resulted in a decrease of high mobility group box 1 (HMGB1), phospho-NF-κB (p-NF-κB), and toll-like receptor 4 (TLR4), and an increase of VE-cadherin. Compared to MPS alone, MPS plus SQV attenuated the decrease of glucocorticoid receptor alpha (GRα) and IκBα in LPS-stimulated HPMECs. HMGB1, TLR4, and p-NF-κB expression were also lessened in LPS-stimulated alveolar macrophages with SQV treatment. In addition, SQV reduced the injury in human AT I with a decrease of HMGB1 and p-NF-κB, and with an increase of aquaporin 5 (AQP 5). SQV ameliorated the lung injury caused by LPS in rats with reductions in vascular permeability, myeloperoxidase activity (MPO) and histopathological scores, and with lowered HMGB1, TLR4, and p-NF-κB expression, but with enhanced VE-cadherin expression. By comparison, SQV plus MPS increased GRα and IκBα in lung tissues of rats with ALI. This study demonstrated that SQV prevented experimental ALI and improved glucocorticoid insensitivity by modulating the HMGB1/TLR4 pathway.
       
  • Transcriptomic differential lncRNA expression is involved in neuropathic
           pain in rat dorsal root ganglion after spared sciatic nerve injury

    • Abstract: Dorsal root ganglia (DRG) neurons regenerate spontaneously after traumatic or surgical injury. Long noncoding RNAs (lncRNAs) are involved in various biological regulation processes. Conditions of lncRNAs in DRG neuron injury deserve to be further investigated. Transcriptomic analysis was performed by high-throughput Illumina HiSeq2500 sequencing to profile the differential genes in L4–L6 DRGs following rat sciatic nerve tying. A total of 1,228 genes were up-regulated and 1,415 down-regulated. By comparing to rat lncRNA database, 86 known and 26 novel lncRNA genes were found to be differential. The 86 known lncRNA genes modulated 866 target genes subject to gene ontology (GO) and KEGG enrichment analysis. The genes involved in the neurotransmitter status of neurons were downregulated and those involved in a neuronal regeneration were upregulated. Known lncRNA gene rno-Cntnap2 was downregulated. There were 13 credible GO terms for the rno-Cntnap2 gene, which had a putative function in cell component of voltage-gated potassium channel complex on the cell surface for neurites. In 26 novel lncRNA genes, 4 were related to 21 mRNA genes. A novel lncRNA gene AC111653.1 improved rno-Hypm synthesizing huntingtin during sciatic nerve regeneration. Real time qPCR results attested the down-regulation of rno-Cntnap lncRNA gene and the upregulation of AC111653.1 lncRNA gene. A total of 26 novel lncRNAs were found. Known lncRNA gene rno-Cntnap2 and novel lncRNA AC111653.1 were involved in neuropathic pain of DRGs after spared sciatic nerve injury. They contributed to peripheral nerve regeneration via the putative mechanisms.
       
  • Intestinal cell migration damage induced by enteropathogenic
           Escherichia coli strains

    • Abstract: Epithelial cell migration is an essential response to enteric pathogens such as enteropathogenic Escherichia coli (EPEC). This study aimed to investigate the effects of EPEC infection on intestinal epithelial cell migration in vitro, as well as the involvement of type III secretion system (T3SS) and Rho GTPases. Crypt intestinal epithelial cells (IEC-6) were infected with EPEC strains (E2348/69, ΔescF, and the LDI001 strain isolated from a malnourished Brazilian child) and commensal E. coli HS. Wound migration and cell death assays were performed at different time-points. Transcription and expression of Rho GTPases were evaluated using real-time PCR and western blotting. Overall, EPEC E2348/69 reduced migration and increased apoptosis and necrosis levels compared to EPEC LDI001 and E. coli HS strains. Moreover, EPEC LDI001 impaired cell migration at a higher level than E. coli HS and increased necrosis after 24 hours compared to the control group. The different profiles of virulence genes between the two wild-type EPEC strains, characterized by the absence of espL and nleE genes in the LDI001, might explain the phenotypic results, playing significant roles on cell migration impairment and cell death-related events. Moreover, the type III secretion system is determinant for the inhibition of intestinal epithelial cell migration by EPEC 2348/69, as its deletion prevented the effect. Active Rac1 concentrations were increased in E2348/69 and LDI001-infected cells, while the T3SS-deficient strain did not demonstrate this activation. This study contributes with valuable insight to characterize the mechanisms involved in the impairment of intestinal cell migration induced by EPEC.
       
 
 
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