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Publisher: SciELO   (Total: 791 journals)

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ABCD. Arquivos Brasileiros de Cirurgia Digestiva     Open Access   (Followers: 4)
ACIMED     Open Access   (SJR: 0.11, h-index: 4)
Acta Amazonica     Open Access   (Followers: 3, SJR: 0.319, h-index: 13)
Acta Bioethica     Open Access   (Followers: 3, SJR: 0.119, h-index: 3)
Acta Bioquimica Clinica Latinoamericana     Open Access   (Followers: 2, SJR: 0.134, h-index: 7)
Acta Botanica Brasilica     Open Access   (Followers: 2, SJR: 0.403, h-index: 17)
Acta botánica mexicana     Open Access   (SJR: 0.212, h-index: 4)
Acta Cirurgica Brasileira     Open Access   (SJR: 0.271, h-index: 14)
Acta Limnologica Brasiliensia     Open Access   (Followers: 2, SJR: 0.204, h-index: 2)
Acta Literaria     Open Access   (Followers: 2, SJR: 0.1, h-index: 2)
Acta Médica Costarricense     Open Access   (Followers: 1)
Acta Medica Peruana     Open Access   (Followers: 2)
Acta Neurológica Colombiana     Open Access   (Followers: 1)
Acta Odontológica Latinoamericana     Open Access  
Acta Ortopédica Brasileira     Open Access   (Followers: 2, SJR: 0.159, h-index: 9)
Acta Paulista de Enfermagem     Open Access   (Followers: 1, SJR: 0.34, h-index: 12)
Acta Pediátrica Costarricense     Open Access   (Followers: 1)
Acta Scientiarum. Agronomy     Open Access   (Followers: 4, SJR: 0.65, h-index: 11)
Acta Toxicológica Argentina     Open Access  
Acta zoológica mexicana     Open Access  
Actualidades Biológicas     Open Access  
African Human Rights Law J.     Open Access   (Followers: 18)
African Natural History     Open Access   (Followers: 2)
Afro-Asia     Open Access  
Ágora - studies in psychoanalytic theory     Open Access   (Followers: 2, SJR: 0.1, h-index: 1)
Agricultura Tecnica     Open Access   (Followers: 6)
Agriscientia     Open Access  
Agrociencia     Open Access   (Followers: 2, SJR: 0.192, h-index: 13)
Agrociencia Uruguay     Open Access  
Agronomía Mesoamericana     Open Access  
Aisthesis     Open Access   (Followers: 1)
Alea : Estudos Neolatinos     Open Access   (Followers: 1, SJR: 0.126, h-index: 2)
Alpha (Osorno)     Open Access   (Followers: 1)
Ambiente & sociedade     Open Access   (Followers: 2, SJR: 0.189, h-index: 5)
Ambiente & Agua : An Interdisciplinary J. of Applied Science     Open Access   (Followers: 1)
Ambiente Construído     Open Access   (Followers: 2)
América Latina en la historia económica     Open Access   (Followers: 1, SJR: 0.101, h-index: 1)
Anais Brasileiros de Dermatologia     Open Access   (Followers: 2, SJR: 0.456, h-index: 16)
Anais da Academia Brasileira de Ciências     Open Access   (Followers: 2, SJR: 0.344, h-index: 34)
Anais do Museu Paulista : História e Cultura Material     Open Access   (Followers: 1)
Anales de Medicina Interna     Open Access   (Followers: 1)
Anales del Instituto de la Patagonia     Open Access   (Followers: 1)
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1, SJR: 0.179, h-index: 15)
Análise Psicológica     Open Access  
Análise Social     Open Access  
Análisis filosófico     Open Access  
Analisis Politico     Open Access   (Followers: 3, SJR: 0.1, h-index: 2)
Andean geology     Open Access   (Followers: 4, SJR: 0.825, h-index: 22)
Angiologia e Cirurgia Vascular     Open Access  
Annali dell'Istituto Superiore di Sanità     Open Access   (SJR: 0.272, h-index: 25)
Anuario Colombiano de Historia Social y de la Cultura     Open Access   (Followers: 1)
Apuntes : Revista de Estudios sobre Patrimonio Cultural - J. of Cultural Heritage Studies     Open Access   (Followers: 4)
Archivos argentinos de pediatría     Open Access  
Archivos de cardiología de México     Open Access   (Followers: 1, SJR: 0.136, h-index: 11)
Archivos de Medicina Interna     Open Access  
Archivos de Medicina Veterinaria     Open Access   (Followers: 1, SJR: 0.249, h-index: 13)
Archivos de Neurociencias     Open Access   (Followers: 2, SJR: 0.104, h-index: 4)
Archivos de Pediatria del Uruguay     Open Access   (Followers: 2)
Archivos de Zootecnia     Open Access   (Followers: 4, SJR: 0.231, h-index: 6)
Archivos Españoles de Urología     Open Access   (SJR: 0.228, h-index: 16)
Archivos Venezolanos de Farmacología y Terapéutica     Open Access   (Followers: 1, SJR: 0.102, h-index: 2)
Argos     Open Access   (Followers: 2, SJR: 0.1, h-index: 1)
ARQ     Open Access   (Followers: 4, SJR: 0.1, h-index: 1)
Arquitectura y Urbanismo     Open Access   (Followers: 2)
Arquivo Brasileiro de Medicina Veterinária e Zootecnia     Open Access   (Followers: 1, SJR: 0.292, h-index: 18)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 1, SJR: 0.33, h-index: 29)
Arquivos Brasileiros de Endocrinologia e Metabologia     Open Access   (SJR: 0.329, h-index: 26)
Arquivos Brasileiros de Oftalmologia     Open Access   (SJR: 0.298, h-index: 15)
Arquivos de Gastroenterologia     Open Access   (Followers: 1, SJR: 0.43, h-index: 18)
Arquivos de Medicina     Open Access  
Arquivos de Neuro-Psiquiatria     Open Access   (SJR: 0.357, h-index: 33)
Arquivos do Instituto Biológico     Open Access  
Arquivos Internacionais de Otorrinolaringologia     Open Access  
ARS     Open Access   (Followers: 3)
Atenea (Concepción)     Open Access   (Followers: 1, SJR: 0.1, h-index: 2)
Atmósfera     Open Access   (SJR: 0.346, h-index: 13)
Audiology - Communication Research     Open Access   (Followers: 8)
Avaliação : Revista da Avaliação da Educação Superior (Campinas)     Open Access  
Avances en Odontoestomatologia     Open Access   (SJR: 0.112, h-index: 4)
Avances en Periodoncia e Implantología Oral     Open Access   (Followers: 5)
Bakhtiniana : Revista de Estudos do Discurso     Open Access  
BAR. Brazilian Administration Review     Open Access   (Followers: 1, SJR: 0.165, h-index: 4)
Biocell     Open Access   (SJR: 0.228, h-index: 19)
Biota Neotropica     Open Access   (SJR: 0.437, h-index: 12)
Biotecnología Aplicada     Open Access  
Boletim de Ciências Geodésicas     Open Access   (SJR: 0.202, h-index: 4)
Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas     Open Access   (Followers: 1, SJR: 0.201, h-index: 2)
Boletin Chileno de Parasitologia     Open Access  
Boletín de Filología     Open Access  
Boletín de Historia Argentina y Americana Dr. Emilio Ravignani     Open Access   (Followers: 1)
Boletin de la Sociedad Argentina de Botanica     Open Access   (Followers: 1, SJR: 0.191, h-index: 3)
Boletín de la Sociedad Botánica de México     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Boletín de la Sociedad Geológica Mexicana     Open Access   (SJR: 0.206, h-index: 7)
Boletín del Museo Chileno de Arte Precolombino     Open Access   (Followers: 1)
Bosque     Open Access   (Followers: 1, SJR: 0.245, h-index: 7)
Bragantia     Open Access   (Followers: 2, SJR: 0.685, h-index: 18)
Brazilian Archives of Biology and Technology     Open Access   (Followers: 2, SJR: 0.237, h-index: 24)
Brazilian Dental J.     Open Access   (Followers: 2, SJR: 0.433, h-index: 28)
Brazilian J. of Biology     Open Access   (Followers: 3, SJR: 0.436, h-index: 30)

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Journal Cover Brazilian Journal of Medical and Biological Research
  [SJR: 0.431]   [H-I: 62]   [0 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0100-879X - ISSN (Online) 1414-431X
   Published by SciELO Homepage  [791 journals]
  • Ropinirole alters gene expression profiles in SH-SY5Y cells: a whole
           genome microarray study

    • Abstract: Ropinirole (ROP) is a dopamine agonist that has been used as therapy for Parkinson's disease. In the present study, we aimed to detect whether gene expression was modulated by ROP in SH-SY5Y cells. SH-SY5Y cell lines were treated with 10 µM ROP for 2 h, after which total RNA was extracted for whole genome analysis. Gene expression profiling revealed that 113 genes were differentially expressed after ROP treatment compared with control cells. Further pathway analysis revealed modulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway, with prominent upregulation of PIK3C2B. Moreover, batches of regulated genes, including PIK3C2B, were found to be located on chromosome 1. These findings were validated by quantitative RT-PCR and Western blot analysis. Our study, therefore, revealed that ROP altered gene expression in SH-SY5Y cells, and future investigation of PIK3C2B and other loci on chromosome 1 may provide long-term implications for identifying novel target genes of Parkinson's disease.
       
  • Homocysteine induces glyceraldehyde-3-phosphate dehydrogenase acetylation
           and apoptosis in the neuroblastoma cell line Neuro2a

    • Abstract: High plasma levels of homocysteine (Hcy) promote the progression of neurodegenerative diseases. However, the mechanism by which Hcy mediates neurotoxicity has not been elucidated. We observed that upon incubation with Hcy, the viability of a neuroblastoma cell line Neuro2a declined in a dose-dependent manner, and apoptosis was induced within 48 h. The median effective concentration (EC50) of Hcy was approximately 5 mM. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) nuclear translocation and acylation has been implicated in the regulation of apoptosis. We found that nuclear translocation and acetylation of GAPDH increased in the presence of 5 mM Hcy and that higher levels of acetyltransferase p300/CBP were detected in Neuro2a cells. These findings implicate the involvement of GAPDH in the mechanism whereby Hcy induces apoptosis in neurons. This study highlights a potentially important pathway in neurodegenerative disorders, and a novel target pathway for neuroprotective therapy.
       
  • Lyophilized allografts without pre-treatment with glutaraldehyde are more
           suitable than cryopreserved allografts for pulmonary artery reconstruction
           

    • Abstract: Various methods are available for preservation of vascular grafts for pulmonary artery (PA) replacement. Lyophilization and cryopreservation reduce antigenicity and prevent thrombosis and calcification in vascular grafts, so both methods can be used to obtain vascular bioprostheses. We evaluated the hemodynamic, gasometric, imaging, and macroscopic and microscopic findings produced by PA reconstruction with lyophilized (LyoPA) grafts and cryopreserved (CryoPA) grafts in dogs. Eighteen healthy crossbred adult dogs of both sexes weighing between 18 and 20 kg were used and divided into three groups of six: group I, PA section and reanastomosis; group II, PA resection and reconstruction with LyoPA allograft; group III, PA resection and reconstruction with CryoPA allograft. Dogs were evaluated 4 weeks after surgery, and the status of the graft and vascular anastomosis were examined macroscopically and microscopically. No clinical, radiologic, or blood-gas abnormalities were observed during the study. The mean pulmonary artery pressure (MPAP) in group III increased significantly at the end of the study compared with baseline (P=0.02) and final [P=0.007, two-way repeat-measures analysis of variance (RM ANOVA)] values. Pulmonary vascular resistance of groups II and III increased immediately after reperfusion and also at the end of the study compared to baseline. The increase shown by group III vs group I was significant only if compared with after surgery and study end (P=0.016 and P=0.005, respectively, two-way RM ANOVA). Microscopically, permeability was reduced by ≤75% in group III. In conclusion, substitution of PAs with LyoPA grafts is technically feasible and clinically promising.
       
  • β-Citronellol, an alcoholic monoterpene with inhibitory properties on
           the contractility of rat trachea

    • Abstract: β-Citronellol is an alcoholic monoterpene found in essential oils such Cymbopogon citratus (a plant with antihypertensive properties). β-Citronellol can act against pathogenic microorganisms that affect airways and, in virtue of the popular use of β-citronellol-enriched essential oils in aromatherapy, we assessed its pharmacologic effects on the contractility of rat trachea. Contractions of isolated tracheal rings were recorded isometrically through a force transducer connected to a data-acquisition device. β-Citronellol relaxed sustained contractions induced by acetylcholine or high extracellular potassium, but half-maximal inhibitory concentrations (IC50) for K+-elicited stimuli were smaller than those for cholinergic contractions. It also inhibited contractions induced by electrical field stimulation or sodium orthovanadate with pharmacologic potency equivalent to that seen against acetylcholine-induced contractions. When contractions were evoked by selective recruitment of Ca2+ from the extracellular medium, β-citronellol preferentially inhibited contractions that involved voltage-operated (but not receptor-operated) pathways. β-Citronellol (but not verapamil) inhibited contractions induced by restoration of external Ca2+ levels after depleting internal Ca2+ stores with the concomitant presence of thapsigargin and recurrent challenge with acetylcholine. Treatment of tracheal rings with L-NAME, indomethacin or tetraethylammonium did not change the relaxing effects of β-citronellol. Inhibition of transient receptor potential vanilloid subtype 1 (TRPV1) or transient receptor potential ankyrin 1 (TRPA1) receptors with selective antagonists caused no change in the effects of β-citronellol. In conclusion, β-citronellol exerted inhibitory effects on rat tracheal rings, with predominant effects on contractions that recruit Ca2+ inflow towards the cytosol by voltage-gated pathways, whereas it appears less active against contractions elicited by receptor-operated Ca2+ channels.
       
  • Acute but not chronic metabolic acidosis potentiates the
           acetylcholine-induced reduction in blood pressure: an
           endothelium-dependent effect

    • Abstract: Metabolic acidosis has profound effects on vascular tone. This study investigated the in vivo effects of acute metabolic acidosis (AMA) and chronic metabolic acidosis (CMA) on hemodynamic parameters and endothelial function. CMA was induced by ad libitum intake of 1% NH4Cl for 7 days, and AMA was induced by a 3-h infusion of 6 M NH4Cl (1 mL/kg, diluted 1:10). Phenylephrine (Phe) and acetylcholine (Ach) dose-response curves were performed by venous infusion with simultaneous venous and arterial blood pressure monitoring. Plasma nitrite/nitrate (NOx) was measured by chemiluminescence. The CMA group had a blood pH of 7.15±0.03, which was associated with reduced bicarbonate (13.8±0.98 mmol/L) and no change in the partial pressure of arterial carbon dioxide (PaCO2). The AMA group had a pH of 7.20±0.01, which was associated with decreases in bicarbonate (10.8±0.54 mmol/L) and PaCO2 (47.8±2.54 to 23.2±0.74 mmHg) and accompanied by hyperventilation. Phe or ACh infusion did not affect arterial or venous blood pressure in the CMA group. However, the ACh infusion decreased the arterial blood pressure (ΔBP: -28.0±2.35 mm Hg [AMA] to -4.5±2.89 mmHg [control]) in the AMA group. Plasma NOx was normal after CMA but increased after AMA (25.3±0.88 to 31.3±0.54 μM). These results indicate that AMA, but not CMA, potentiated the Ach-induced decrease in blood pressure and led to an increase in plasma NOx, reinforcing the effect of pH imbalance on vascular tone and blood pressure control.
       
  • Three days of intermittent stretching after muscle disuse alters the
           

    • Abstract: The aim of this study was to determine the effects of intermittent passive manual stretching on various proteins involved in force transmission in skeletal muscle. Female Wistar weanling rats were randomly assigned to 5 groups: 2 control groups containing 21- and 30-day-old rats that received neither immobilization nor stretching, and 3 test groups that received 1) passive stretching over 3 days, 2) immobilization for 7 days and then passive stretching over 3 days, or 3) immobilization for 7 days. Maximal plantar flexion in the right hind limb was imposed, and the stretching protocol of 10 repetitions of 30 s stretches was applied. The soleus muscles were harvested and processed for HE and picrosirius staining; immunohistochemical analysis of collagen types I, III, IV, desmin, and vimentin; and immunofluorescence labeling of dystrophin and CD68. The numbers of desmin- and vimentin-positive cells were significantly decreased compared with those in the control following immobilization, regardless of whether stretching was applied (P<0.05). In addition, the semi-quantitative analysis showed that collagen type I was increased and type IV was decreased in the immobilized animals, regardless of whether the stretching protocol was applied. In conclusion, the largest changes in response to stretching were observed in muscles that had been previously immobilized, and the stretching protocol applied here did not mitigate the immobilization-induced muscle changes. Muscle disuse adversely affected several proteins involved in the transmission of forces between the intracellular and extracellular compartments. Thus, the 3-day rehabilitation period tested here did not provide sufficient time for the muscles to recover from the disuse maladaptations in animals undergoing postnatal development.
       
  • Single-walled carbon nanotubes functionalized with sodium hyaluronate
           enhance bone mineralization

    • Abstract: The aim of this study was to evaluate the effects of sodium hyaluronate (HY), single-walled carbon nanotubes (SWCNTs) and HY-functionalized SWCNTs (HY-SWCNTs) on the behavior of primary osteoblasts, as well as to investigate the deposition of inorganic crystals on titanium surfaces coated with these biocomposites. Primary osteoblasts were obtained from the calvarial bones of male newborn Wistar rats (5 rats for each cell extraction). We assessed cell viability using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay and by double-staining with propidium iodide and Hoechst. We also assessed the formation of mineralized bone nodules by von Kossa staining, the mRNA expression of bone repair proteins, and the deposition of inorganic crystals on titanium surfaces coated with HY, SWCNTs, or HY-SWCNTs. The results showed that treatment with these biocomposites did not alter the viability of primary osteoblasts. Furthermore, deposition of mineralized bone nodules was significantly increased by cells treated with HY and HY-SWCNTs. This can be partly explained by an increase in the mRNA expression of type I and III collagen, osteocalcin, and bone morphogenetic proteins 2 and 4. Additionally, the titanium surface treated with HY-SWCNTs showed a significant increase in the deposition of inorganic crystals. Thus, our data indicate that HY, SWCNTs, and HY-SWCNTs are potentially useful for the development of new strategies for bone tissue engineering.
       
  • Galantamine protects against lipopolysaccharide-induced acute lung injury
           in rats

    • Abstract: Lipopolysaccharide (LPS)-induced endotoxemia triggers the secretion of proinflammatory cytokines and can cause acute lung injury (ALI). The high mobility group box 1 (HMGB1) protein plays an important role as a late mediator of sepsis and ALI. Galantamine (GAL) is a central acetylcholinesterase inhibitor that inhibits the expression of HMGB1. This study evaluated the effects of GAL by measuring levels of inflammatory mediators and observing histopathological features associated with LPS-induced ALI. Sixty 8-10 week old male Sprague-Dawley rats (200-240 g) were randomized into three groups as follows: control group, LPS group (7.5 mg/kg LPS), and LPS+GAL group (5 mg/kg GAL before LPS administration). Histopathological examination of lung specimens obtained 12 h after LPS administration was performed to analyze changes in wet-to-dry (W/D) weight ratio, myeloperoxidase (MPO) activity, and HMGB1 expression level. Additionally, plasma concentrations of tumor necrosis factor-α, interleukin-6, and HMGB1 were measured using an enzyme-linked immunosorbent assay at 0 (baseline), 3, 6, 9, and 12 h after LPS administration. Mortality in the three groups was recorded at 72 h. LPS-induced ALI was characterized by distortion of pulmonary architecture and elevation of MPO activity, W/D weight ratio, and levels of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-6, and HMGB1. Pretreatment with GAL significantly reduced the LPS-induced lung pathological changes, W/D weight ratio, levels of pro-inflammatory cytokines and MPO activity (ANOVA). Moreover, GAL treatment significantly decreased the mortality rate (ANOVA). In conclusion, we demonstrated that GAL exerted a protective effect on LPS-induced ALI in rats.
       
 
 
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