for Journals by Title or ISSN
for Articles by Keywords
help

Publisher: SciELO   (Total: 729 journals)

 A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z  

        1 2 3 4 | Last   [Sort by number of followers]   [Restore default list]

Showing 1 - 200 of 729 Journals sorted alphabetically
ABCD. Arquivos Brasileiros de Cirurgia Digestiva     Open Access   (Followers: 2)
ACIMED     Open Access   (SJR: 0.11, h-index: 4)
Acta Amazonica     Open Access   (Followers: 2, SJR: 0.319, h-index: 13)
Acta Bioethica     Open Access   (Followers: 1, SJR: 0.119, h-index: 3)
Acta Botanica Brasilica     Open Access   (Followers: 1, SJR: 0.403, h-index: 17)
Acta botánica mexicana     Open Access   (SJR: 0.212, h-index: 4)
Acta Cirurgica Brasileira     Open Access   (SJR: 0.271, h-index: 14)
Acta Limnologica Brasiliensia     Open Access   (Followers: 2, SJR: 0.204, h-index: 2)
Acta Literaria     Open Access   (Followers: 2, SJR: 0.1, h-index: 2)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Medica Peruana     Open Access   (Followers: 1)
Acta Neurológica Colombiana     Open Access   (Followers: 1)
Acta Ortopédica Brasileira     Open Access   (Followers: 1, SJR: 0.159, h-index: 9)
Acta Paulista de Enfermagem     Open Access   (Followers: 2, SJR: 0.34, h-index: 12)
Acta Pediátrica Costarricense     Open Access   (Followers: 1)
Acta Scientiarum. Agronomy     Open Access   (Followers: 4, SJR: 0.65, h-index: 11)
Acta zoológica mexicana     Open Access  
Actualidades Biológicas     Open Access   (Followers: 1)
African Human Rights Law J.     Open Access   (Followers: 17)
African Natural History     Open Access   (Followers: 1)
Afro-Asia     Open Access  
Ágora - studies in psychoanalytic theory     Open Access   (Followers: 2, SJR: 0.1, h-index: 1)
Agricultura Tecnica     Open Access   (Followers: 6)
Agrociencia     Open Access   (Followers: 1, SJR: 0.192, h-index: 13)
Agrociencia Uruguay     Open Access  
Agronomía Mesoamericana     Open Access  
Aisthesis     Open Access   (Followers: 1)
Alea : Estudos Neolatinos     Open Access   (Followers: 1, SJR: 0.126, h-index: 2)
Alpha (Osorno)     Open Access  
Ambiente & sociedade     Open Access   (Followers: 2, SJR: 0.189, h-index: 5)
Ambiente & Agua : An Interdisciplinary J. of Applied Science     Open Access   (Followers: 1)
Ambiente Construído     Open Access   (Followers: 1)
América Latina en la historia económica     Open Access   (Followers: 1, SJR: 0.101, h-index: 1)
Anais Brasileiros de Dermatologia     Open Access   (Followers: 2, SJR: 0.456, h-index: 16)
Anais da Academia Brasileira de Ciências     Open Access   (Followers: 2, SJR: 0.344, h-index: 34)
Anais do Museu Paulista : História e Cultura Material     Open Access   (Followers: 1)
Anales de Medicina Interna     Open Access   (Followers: 1)
Anales del Instituto de la Patagonia     Open Access   (Followers: 1)
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1, SJR: 0.179, h-index: 15)
Análise Psicológica     Open Access  
Análise Social     Open Access  
Analisis Politico     Open Access   (Followers: 3, SJR: 0.1, h-index: 2)
Andean geology     Open Access   (Followers: 3, SJR: 0.825, h-index: 22)
Annali dell'Istituto Superiore di Sanità     Open Access   (SJR: 0.272, h-index: 25)
Anuario Colombiano de Historia Social y de la Cultura     Open Access  
Anuario de Historia Regional y de las Fronteras     Open Access  
Apuntes : Revista de Estudios sobre Patrimonio Cultural - J. of Cultural Heritage Studies     Open Access   (Followers: 3)
Archivos de cardiología de México     Open Access   (Followers: 1, SJR: 0.136, h-index: 11)
Archivos de Medicina Interna     Open Access  
Archivos de Medicina Veterinaria     Open Access   (Followers: 1, SJR: 0.249, h-index: 13)
Archivos de Neurociencias     Open Access   (Followers: 2, SJR: 0.104, h-index: 4)
Archivos de Pediatria del Uruguay     Open Access   (Followers: 3)
Archivos de Zootecnia     Open Access   (Followers: 1, SJR: 0.231, h-index: 6)
Archivos Españoles de Urología     Open Access   (SJR: 0.228, h-index: 16)
Archivos Venezolanos de Farmacología y Terapéutica     Open Access   (SJR: 0.102, h-index: 2)
ARQ     Open Access   (Followers: 3, SJR: 0.1, h-index: 1)
Arquitectura y Urbanismo     Open Access   (Followers: 2)
Arquivo Brasileiro de Medicina Veterinária e Zootecnia     Open Access   (SJR: 0.292, h-index: 18)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 1, SJR: 0.33, h-index: 29)
Arquivos Brasileiros de Endocrinologia e Metabologia     Open Access   (SJR: 0.329, h-index: 26)
Arquivos Brasileiros de Oftalmologia     Open Access   (SJR: 0.298, h-index: 15)
Arquivos de Gastroenterologia     Open Access   (Followers: 1, SJR: 0.43, h-index: 18)
Arquivos de Medicina     Open Access  
Arquivos de Neuro-Psiquiatria     Open Access   (SJR: 0.357, h-index: 33)
Arquivos do Instituto Biológico     Open Access   (Followers: 1)
Arquivos Internacionais de Otorrinolaringologia     Open Access  
ARS     Open Access   (Followers: 2)
Atenea (Concepción)     Open Access   (SJR: 0.1, h-index: 2)
Atmósfera     Open Access   (Followers: 1, SJR: 0.346, h-index: 13)
Audiology - Communication Research     Open Access   (Followers: 10)
Avaliação : Revista da Avaliação da Educação Superior (Campinas)     Open Access  
Avances en Odontoestomatologia     Open Access   (Followers: 1, SJR: 0.112, h-index: 4)
Avances en Periodoncia e Implantología Oral     Open Access   (Followers: 1)
Bakhtiniana : Revista de Estudos do Discurso     Open Access  
BAR. Brazilian Administration Review     Open Access   (Followers: 1, SJR: 0.165, h-index: 4)
Biocell     Open Access   (SJR: 0.228, h-index: 19)
Biota Neotropica     Open Access   (SJR: 0.437, h-index: 12)
Biotecnología Aplicada     Open Access  
Boletim de Ciências Geodésicas     Open Access   (SJR: 0.202, h-index: 4)
Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas     Open Access   (Followers: 1, SJR: 0.201, h-index: 2)
Boletin Chileno de Parasitologia     Open Access  
Boletín de Filología     Open Access  
Boletín de Historia Argentina y Americana Dr. Emilio Ravignani     Open Access  
Boletín de la Sociedad Botánica de México     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Boletín de la Sociedad Geológica Mexicana     Open Access   (SJR: 0.206, h-index: 7)
Boletín del Museo Chileno de Arte Precolombino     Open Access   (Followers: 1)
Bosque     Open Access   (Followers: 2, SJR: 0.245, h-index: 7)
Bragantia     Open Access   (Followers: 2, SJR: 0.685, h-index: 18)
Brazilian Archives of Biology and Technology     Open Access   (Followers: 1, SJR: 0.237, h-index: 24)
Brazilian Dental J.     Open Access   (Followers: 2, SJR: 0.433, h-index: 28)
Brazilian J. of Biology     Open Access   (Followers: 3, SJR: 0.436, h-index: 30)
Brazilian J. of Chemical Engineering     Open Access   (Followers: 3, SJR: 0.437, h-index: 25)
Brazilian J. of Food Technology     Open Access   (Followers: 3)
Brazilian J. of Medical and Biological Research     Open Access   (SJR: 0.431, h-index: 62)
Brazilian J. of Microbiology     Open Access   (Followers: 2, SJR: 0.321, h-index: 31)
Brazilian J. of Oceanography     Open Access   (Followers: 1, SJR: 0.339, h-index: 8)
Brazilian J. of Oral Sciences     Open Access   (Followers: 1, SJR: 0.136, h-index: 5)
Brazilian J. of Physical Therapy     Open Access   (SJR: 0.53, h-index: 12)
Brazilian J. of Plant Physiology     Open Access   (Followers: 3, SJR: 0.243, h-index: 30)
Brazilian J. of Veterinary Research and Animal Science     Open Access   (Followers: 8, SJR: 0.145, h-index: 8)
Brazilian Oral Research     Open Access  
Brazilian Political Science Review     Open Access  
Bulletin of the World Health Organization     Open Access   (Followers: 13, SJR: 2.395, h-index: 105)
Caderno CRH     Open Access   (SJR: 0.209, h-index: 2)
Caderno de Estudos     Open Access  
Cadernos CEDES     Open Access   (Followers: 1, SJR: 0.12, h-index: 4)
Cadernos de Pesquisa     Open Access   (Followers: 2, SJR: 0.314, h-index: 6)
Cadernos de Saúde Pública     Open Access   (Followers: 1, SJR: 0.673, h-index: 45)
Cadernos Metrópole     Open Access  
Cadernos Nietzsche     Open Access  
Cadernos Pagu     Open Access   (SJR: 0.124, h-index: 2)
Cadernos Saúde Coletiva     Open Access   (Followers: 1)
Calidad en la educación     Open Access   (Followers: 1)
Cerâmica     Open Access   (Followers: 3, SJR: 0.198, h-index: 8)
CES Medicina     Open Access  
Chilean J. of Agricultural Research     Open Access   (Followers: 1, SJR: 0.285, h-index: 10)
Chungara (Arica) - Revista de Antropologia Chilena     Open Access   (Followers: 1, SJR: 0.397, h-index: 10)
Ciência & Educação (Bauru)     Open Access  
Ciência & Saúde Coletiva     Open Access   (Followers: 2, SJR: 0.635, h-index: 23)
Ciência Animal Brasileira     Open Access   (SJR: 0.14, h-index: 2)
Ciência da Informação     Open Access   (Followers: 1, SJR: 0.132, h-index: 5)
Ciência e Agrotecnologia     Open Access   (SJR: 0.618, h-index: 14)
Ciencia e Cultura     Open Access   (Followers: 1)
Ciencia e investigación agraria     Open Access   (SJR: 0.196, h-index: 7)
Ciencia forestal en México     Open Access  
Ciência Rural     Open Access   (Followers: 2, SJR: 0.384, h-index: 17)
Ciencia y Enfermeria - Revista Iberoamericana de Investigacion     Open Access   (Followers: 3, SJR: 0.166, h-index: 5)
Ciencias Marinas     Open Access   (Followers: 1, SJR: 0.356, h-index: 17)
Ciencias Psicológicas     Open Access  
Cirugia Plastica Ibero-Latinoamericana     Open Access   (SJR: 0.186, h-index: 7)
CLEI Electronic J.     Open Access  
Clínica y Salud     Open Access  
Clinics     Open Access   (SJR: 0.47, h-index: 29)
CoDAS     Open Access  
Computación y Sistemas     Open Access   (SJR: 0.131, h-index: 2)
Comuni@cción     Open Access  
Comunicación y sociedad     Open Access   (Followers: 2, SJR: 0.363, h-index: 4)
Contaduría y Administración     Open Access  
Contexto Internacional     Open Access  
Convergencia     Open Access   (SJR: 0.119, h-index: 3)
Correo Científico Médico     Open Access  
Corrosão e Protecção de Materiais     Open Access  
Crop Breeding and Applied Biotechnology     Open Access   (Followers: 4, SJR: 0.4, h-index: 10)
Cuaderno urbano     Open Access  
Cuadernos de Economía     Open Access   (Followers: 1)
Cuadernos de Economia - Latin American J. of Economics     Open Access   (Followers: 1)
Cuadernos de Historia     Open Access   (Followers: 3)
Cuadernos de Historia de la Salud Publica     Open Access  
Cuadernos de Investigación Educativa     Open Access   (Followers: 1)
Cuadernos de Medicina Forense     Open Access   (Followers: 2, SJR: 0.102, h-index: 3)
Cuadernos.info     Open Access  
Cubo. A Mathematical J.     Open Access  
Cuicuilco     Open Access   (Followers: 1)
Cultivos Tropicales     Open Access  
Culturales     Open Access   (Followers: 2)
Dados - Revista de Ciências Sociais     Open Access   (SJR: 0.339, h-index: 13)
De Jure     Open Access  
DELTA : Documentação de Estudos em Lingüística Teórica e Aplicada     Open Access   (SJR: 0.108, h-index: 3)
Dementia & Neuropsychologia     Open Access   (Followers: 1)
Dental Press J. of Orthodontics     Open Access   (Followers: 2, SJR: 0.191, h-index: 5)
Desacatos     Open Access   (Followers: 1)
Desarrollo y Sociedad     Open Access   (Followers: 3, SJR: 0.14, h-index: 1)
Diálogo Andino - Revista de Historia, Geografía y Cultura Andina     Open Access  
Diánoia     Open Access   (Followers: 1)
Dimensión Empresarial     Open Access  
Dynamis : Acta Hispanica ad Medicinae Scientiarumque Historiam Illustrandam     Open Access   (Followers: 1)
e-J. of Portuguese History     Open Access   (Followers: 1)
Eclética Química     Open Access   (Followers: 1, SJR: 0.115, h-index: 11)
Ecología en Bolivia     Open Access  
Economia Aplicada     Open Access   (SJR: 0.258, h-index: 4)
Economia e Sociedade     Open Access  
EconoQuantum     Open Access  
Educação & Sociedade     Open Access   (Followers: 2, SJR: 0.394, h-index: 8)
Educação e Pesquisa     Open Access   (SJR: 0.204, h-index: 6)
Educação em Revista     Open Access  
Educación Matemática     Open Access  
Educación Médica     Open Access   (Followers: 1, SJR: 0.109, h-index: 5)
Educación Médica Superior     Open Access   (Followers: 1, SJR: 0.111, h-index: 6)
Educación y Educadores     Open Access   (Followers: 1)
Educar em Revista     Open Access  
EDUMECENTRO     Open Access  
Electronic J. of Biotechnology     Open Access   (Followers: 1, SJR: 0.303, h-index: 30)
En-Claves del pensamiento     Open Access  
Encuentros     Open Access  
Ene : Revista de Enfermería     Open Access  
Enfermería Global     Open Access   (Followers: 3, SJR: 0.113, h-index: 1)
Enfermería Nefrológica     Open Access   (Followers: 1)
Engenharia Agrícola     Open Access   (SJR: 0.505, h-index: 13)
Engenharia Sanitaria e Ambiental     Open Access   (SJR: 0.194, h-index: 7)
Ensaio Avaliação e Políticas Públicas em Educação     Open Access   (Followers: 1, SJR: 0.283, h-index: 4)
Entomologia y Vectores     Open Access   (Followers: 2)
Escritos de Psicología : Psychological Writings     Open Access   (Followers: 1)
Estudios Atacameños     Open Access   (Followers: 2, SJR: 0.172, h-index: 5)
Estudios Constitucionales     Open Access   (Followers: 4, SJR: 0.7, h-index: 3)
Estudios de Cultura Maya     Open Access   (Followers: 3)
Estudios de Economía     Open Access   (SJR: 0.109, h-index: 4)
Estudios de historia moderna y contemporánea de México     Open Access   (SJR: 0.101, h-index: 1)
Estudios Filologicos     Open Access   (SJR: 0.12, h-index: 2)
Estudios Fronterizos     Open Access  

        1 2 3 4 | Last   [Sort by number of followers]   [Restore default list]

Journal Cover Brazilian Journal of Medical and Biological Research
  [SJR: 0.431]   [H-I: 62]   [0 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0100-879X - ISSN (Online) 1414-431X
   Published by SciELO Homepage  [729 journals]
  • Obesity inversely correlates with prostate-specific antigen levels in a
           population with normal screening results of prostate cancer in
           northwestern China

    • Abstract: Serum prostate-specific antigen (PSA) is a diagnostic biomarker of prostate cancer and is possibly associated with obesity. This study aimed to explore the relationships between obesity indicators [body mass index (BMI) and waist circumference (WC)] with PSA in Chinese men. A cross-sectional study of men aged 30-85 years undergoing prostate cancer screening was conducted from August 2008 to July 2013 in Xi'an, China. Data were obtained from clinical reports, condition was recorded based on self-report including demographics, weight, height, and WC (>90 cm=obese). Fasting blood glucose (FBG) and prostate volume (PV) were assessed clinically. Patients were grouped by BMI (normal=22.9, overweight=23-27.4, obese≥27.5 kg/m2). PSA parameters of density (PSAD), PSA serum level, and PSA increasing rate per year (PSAR) were calculated per BMI and age groups (30-40, 41-59, 60-85 years). Obesity indicators (BMI and WC) and PSA parameter relationships were modeled by age-stratified linear regression. Of 35,632 Chinese men surveyed, 13,084 were analyzed, including 13.44% obese, 57.44% overweight, and 29.12% normal weight, according to BMI; 25.84% were centrally (abdominally) obese according to WC. BMI and WC were negatively associated with all PSA parameters, except PSAD and PSAR [P<0.05, BMI: β=-0.081 (95%CI=-0.055 to -0.036), WC: β=-0.101 (-0.021 to -0.015)], and independent of FBG and PV (P<0.05) in an age-adjusted model. In conclusion, obesity was associated with lower PSA in Chinese men. Therefore, an individual's BMI and WC should be considered when PSA is used to screen for prostate cancer.
       
  • Does the incremental shuttle walk test require maximal effort in young
           obese women?

    • Abstract: Obesity is a chronic disease with a multifaceted treatment approach that includes nutritional counseling, structured exercise training, and increased daily physical activity. Increased body mass elicits higher cardiovascular, ventilatory and metabolic demands to varying degrees during exercise. With functional capacity assessment, this variability can be evaluated so individualized guidance for exercise training and daily physical activity can be provided. The aim of the present study was to compare cardiovascular, ventilatory and metabolic responses obtained during a symptom-limited cardiopulmonary exercise test (CPX) on a treadmill to responses obtained by the incremental shuttle walk test (ISWT) in obese women and to propose a peak oxygen consumption (VO2) prediction equation through variables obtained during the ISWT. Forty obese women (BMI ≥30 kg/m2) performed one treadmill CPX and two ISWTs. Heart rate (HR), arterial blood pressure (ABP) and perceived exertion by the Borg scale were measured at rest, during each stage of the exercise protocol, and throughout the recovery period. The predicted maximal heart rate (HRmax) was calculated (210 – age in years) (16) and compared to the HR response during the CPX. Peak VO2 obtained during CPX correlated significantly (P<0.05) with ISWT peak VO2 (r=0.79) as well as ISWT distance (r=0.65). The predictive model for CPX peak VO2, using age and ISWT distance explained 67% of the variability. The current study indicates the ISWT may be used to predict aerobic capacity in obese women when CPX is not a viable option.
       
  • Blood levels of pro-inflammatory and anti-inflammatory cytokines during an
           oral glucose tolerance test in patients with symptoms suggesting reactive
           hypoglycemia

    • Abstract: We evaluated the impact of postprandial glycemia on blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in non-diabetic patients with symptoms suggesting reactive hypoglycemia. Eleven patients with clinical symptoms suggesting reactive hypoglycemia received an oral glucose solution (75 g) Blood was collected at 0 (baseline), 30, 60, 120 and 180 min after glucose ingestion and the plasma concentrations of interferon-α (IFN-α), interferon-γ (IFN-γ), interleukin-1 receptor antagonist (IL-1RA), interleukin 2 (IL-2), interleukin-2 receptor (IL-2R), interleukin 4 (IL-4), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10), interleukin-12 (IL-12), interleukin 13 (IL-13), interleukin 15 (IL-15), interleukin 17 (IL-17), IFN-γ inducible protein 10 (IP-10), monocyte chemotactic protein 1 (MCP1), monokine induced by IFN-γ (MIG), macrophage inflammatory protein-1α (MIP-1α), interleukin-1β (IL-1β), colony stimulating factor (G-CSF), granulocyte-macrophage CSF (GM-CSF), basic fibroblast growth factor (FGF-basic), eotaxin, tumor necrosis factor α (TNFα), epidermal growth factor (EGF), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), macrophage inflammatory protein-1α (MIP-1α), and 1β (MIP-1β) were evaluated. Overall, glycemic levels increased, reached its maximum at 30 min (phase 1), returned to baseline levels at 120 min (phase 2), followed by a mild hypoglycemia at 180 min (phase 3). During phase 1, cytokine blood levels were maintained. However, we observed a synchronous fall (P<0.05) in the concentrations of pro-inflammatory (IL-15, IL-17, MCP-1) and anti-inflammatory cytokines (FGF-basic, IL-13, IL-1RA) during phase 2. Furthermore, a simultaneous rise (P<0.05) of pro-inflammatory (IL-2, IL-5, IL-17) and anti-inflammatory cytokines (IL-4, IL-1RA, IL-2R, IL-13, FGF-basic) occurred during phase 3. Thus, mild acute hypoglycemia but not a physiological increase of glycemia was associated with increased blood levels of anti-inflammatory and pro-inflammatory cytokines.
       
  • Effects of fluoride on proliferation and mineralization in periodontal
           ligament cells in vitro

    • Abstract: Fluoride, which is often added to toothpaste or mouthwash in order to protect teeth from decay, may be a novel therapeutic approach for acceleration of periodontal regeneration. Therefore, we investigated the effects of fluoride on proliferation and mineralization in human periodontal ligament cells in vitro. The periodontal ligament cells were stimulated with various concentrations of NaF added into osteogenic inductive medium. Immunohistochemistry of cell identification, cell proliferation, alkaline phosphatase (ALP) activity assay, Alizarin red S staining and quantitative real-time-polymerase chain reaction (RT-PCR) were performed. Moderate concentrations of NaF (50-500 μmol/L) had pro-proliferation effects, while 500 μmol/L had the best effects. ALP activity and calcium content were significantly enhanced by 10 μmol/L NaF with osteogenic inductive medium. Quantitative RT-PCR data varied in genes as a result of different NaF concentrations and treatment periods. We conclude that moderate concentrations of NaF can stimulate proliferation and mineralization in periodontal ligament cells. These in vitro findings may provide a novel therapeutic approach for acceleration of periodontal regeneration by addition of suitable concentrations of NaF into the medication for periodontitis treatment, i.e., into periodontal packs and tissue patches.
       
  • Sida tuberculata (Malvaceae): a study based on development of
           

    • Abstract: Sida tuberculata (Malvaceae) is a medicinal plant traditionally used in Brazil as an antimicrobial and anti-inflammatory agent. Here, we aimed to investigate the different extractive techniques on phytochemical parameters, as well as to evaluate the toxicity and antioxidant capacity of S. tuberculata extracts using in silico and in vitro models. Therefore, in order to determine the dry residue content and the main compound 20-hydroxyecdysone (20E) concentration, extracts from leaves and roots were prepared testing ethanol and water in different proportions. Extracts were then assessed by Artemia salina lethality test, and toxicity prediction of 20E was estimated. Antioxidant activity was performed by DPPH and ABTS radical scavenger assays, ferric reducing power assay, nitrogen derivative scavenger, deoxyribose degradation, and TBARS assays. HPLC evaluation detected 20E as main compound in leaves and roots. Percolation method showed the highest concentrations of 20E (0.134 and 0.096 mg/mL of extract for leaves and roots, respectively). All crude extracts presented low toxic potential on A. salina (LD50 >1000 µg/mL). The computational evaluation of 20E showed a low toxicity prediction. For in vitro antioxidant tests, hydroethanolic extracts of leaves were most effective compared to roots. In addition, hydroethanolic extracts presented a higher IC50 antioxidant than aqueous extracts. TBARS formation was prevented by leaves hydroethanolic extract from 0.015 and 0.03 mg/mL and for roots from 0.03 and 0.3 mg/mL on egg yolk and rat tissue, respectively (P<0.05). These findings suggest that S. tuberculata extracts are a considerable source of ecdysteroids and possesses a significant antioxidant property with low toxic potential.
       
  • Enhancement of anti-OVA IgG2c production in vivo by enalapril

    • Abstract: Angiotensin-converting enzyme (ACE) inhibitors have non-hemodynamic, pleiotropic effects on the immune response. The effects of ACE inhibitors on the production of cytokines and T-cell functions are well established. However, little is known on the effects of these medicines on humoral response to foreign antigens. In this study, we investigated the effect of enalapril treatment on ovalbumin (OVA)-specific IgG1 and IgG2c production in mice determined by ELISA. Two groups of 8-week-old C57BL/6 females mice (3–4/group) were subcutaneously immunized with OVA (10 μg/animal) in presence of Alhydrogel (1 mg/mouse) and boosted at day 21. The mice were treated with enalapril (5 mg/kg daily, po) or were left without treatment for one month. The animals were bled from the orbital plexus on days 0, 7, 14, 21, and 28 after the first immunization and the sera were stored at –20°C until usage. OVA-specific serum IgG1 and IgG2c were determined by ELISA using serum from each individual animal. The results showed that enalapril significantly increased anti-OVA serum IgG2c in the secondary response without affecting IgG1 synthesis. These data expand our understanding on the properties of enalapril on the immune response, including antibody production.
       
  • Sentinel node biopsy using blue dye and technetium99 in
           advanced gastric cancer: anatomical drainage and clinical application

    • Abstract: Lymph node metastases are an independent prognosis factor in gastric carcinoma (GC) patients. Radical lymphadenectomy can improve survival but it can also increase surgical morbidity. As a principle, sentinel node (SN) navigation surgery can avoid unnecessary lymphadenectomy without compromising prognosis. In this pilot study, 24 patients with untreated GC were initially screened for SN navigation surgery, of which 12 were eligible. Five patients had T2 tumors, 5 had T3 tumors and 2 had T1 tumors. In 33% of cases, tumor diameter was greater than 5.0 cm. Three hundred and eighty-seven lymph nodes were excised with a median of 32.3 per patient. The SN navigation surgery was feasible in all patients, with a median of 4.5 SNs per patient. The detection success rate was 100%. All the SNs were located in N1 and N2 nodal level. In 70.9% of cases, the SNs were located at lymphatic chains 6 and 7. The SN sensitivity for nodal staging was 91.6%, with 8.3% of false negative. In 4 patients who were initially staged as N0, the SNs were submitted to multisection analyses and immunohistochemistry, confirming the N0 stage, without micrometastases. In one case initially staged as negative for nodal metastases based on SN analyses, metastases in lymph nodes other than SN were found, resulting in a 20% skip metastases incidence. This surgery is a reproducible procedure with 100% detection rate of SN. Tumor size, GC location and obesity were factors that imposed some limitations regarding SN identification. Results from nodal multisection histology and immunohistochemistry analysis did not change initial nodal staging.
       
 
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
 
Home (Search)
Subjects A-Z
Publishers A-Z
Customise
APIs
Your IP address: 54.225.52.83
 
About JournalTOCs
API
Help
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-2016