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Publisher: SciELO   (Total: 726 journals)

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Showing 1 - 200 of 726 Journals sorted alphabetically
ABCD. Arquivos Brasileiros de Cirurgia Digestiva     Open Access   (Followers: 2)
ACIMED     Open Access   (SJR: 0.11, h-index: 4)
Acta Amazonica     Open Access   (Followers: 2, SJR: 0.319, h-index: 13)
Acta Bioethica     Open Access   (Followers: 1, SJR: 0.119, h-index: 3)
Acta Botanica Brasilica     Open Access   (Followers: 2, SJR: 0.403, h-index: 17)
Acta botánica mexicana     Open Access   (Followers: 1, SJR: 0.212, h-index: 4)
Acta Cirurgica Brasileira     Open Access   (SJR: 0.271, h-index: 14)
Acta Limnologica Brasiliensia     Open Access   (Followers: 2, SJR: 0.204, h-index: 2)
Acta Literaria     Open Access   (Followers: 2, SJR: 0.1, h-index: 2)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Medica Peruana     Open Access   (Followers: 1)
Acta Neurológica Colombiana     Open Access   (Followers: 1)
Acta Ortopédica Brasileira     Open Access   (Followers: 1, SJR: 0.159, h-index: 9)
Acta Paulista de Enfermagem     Open Access   (Followers: 2, SJR: 0.34, h-index: 12)
Acta Pediátrica Costarricense     Open Access   (Followers: 1)
Acta Scientiarum. Agronomy     Open Access   (Followers: 4, SJR: 0.65, h-index: 11)
Acta zoológica mexicana     Open Access  
Actualidades Biológicas     Open Access   (Followers: 1)
African Human Rights Law J.     Open Access   (Followers: 17)
African Natural History     Open Access   (Followers: 1)
Afro-Asia     Open Access  
Ágora - studies in psychoanalytic theory     Open Access   (Followers: 2, SJR: 0.1, h-index: 1)
Agricultura Tecnica     Open Access   (Followers: 6)
Agrociencia     Open Access   (Followers: 1, SJR: 0.192, h-index: 13)
Agrociencia Uruguay     Open Access  
Agronomía Mesoamericana     Open Access  
Aisthesis     Open Access   (Followers: 1)
Alea : Estudos Neolatinos     Open Access   (Followers: 1, SJR: 0.126, h-index: 2)
Alpha (Osorno)     Open Access  
Ambiente & sociedade     Open Access   (Followers: 2, SJR: 0.189, h-index: 5)
Ambiente & Agua : An Interdisciplinary J. of Applied Science     Open Access   (Followers: 1)
Ambiente Construído     Open Access   (Followers: 1)
América Latina en la historia económica     Open Access   (Followers: 1, SJR: 0.101, h-index: 1)
Anais Brasileiros de Dermatologia     Open Access   (Followers: 2, SJR: 0.456, h-index: 16)
Anais da Academia Brasileira de Ciências     Open Access   (Followers: 2, SJR: 0.344, h-index: 34)
Anais do Museu Paulista : História e Cultura Material     Open Access   (Followers: 1)
Anales de Medicina Interna     Open Access   (Followers: 1)
Anales del Instituto de la Patagonia     Open Access   (Followers: 1)
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1, SJR: 0.179, h-index: 15)
Análise Psicológica     Open Access  
Análise Social     Open Access  
Analisis Politico     Open Access   (Followers: 3, SJR: 0.1, h-index: 2)
Andean geology     Open Access   (Followers: 3, SJR: 0.825, h-index: 22)
Annali dell'Istituto Superiore di Sanità     Open Access   (SJR: 0.272, h-index: 25)
Anuario Colombiano de Historia Social y de la Cultura     Open Access  
Anuario de Historia Regional y de las Fronteras     Open Access  
Apuntes : Revista de Estudios sobre Patrimonio Cultural - J. of Cultural Heritage Studies     Open Access   (Followers: 3)
Archivos de cardiología de México     Open Access   (Followers: 1, SJR: 0.136, h-index: 11)
Archivos de Medicina Veterinaria     Open Access   (Followers: 1, SJR: 0.249, h-index: 13)
Archivos de Neurociencias     Open Access   (Followers: 2, SJR: 0.104, h-index: 4)
Archivos de Pediatria del Uruguay     Open Access   (Followers: 3)
Archivos de Zootecnia     Open Access   (Followers: 1, SJR: 0.231, h-index: 6)
Archivos Españoles de Urología     Open Access   (SJR: 0.228, h-index: 16)
Archivos Venezolanos de Farmacología y Terapéutica     Open Access   (SJR: 0.102, h-index: 2)
ARQ     Open Access   (Followers: 3, SJR: 0.1, h-index: 1)
Arquitectura y Urbanismo     Open Access   (Followers: 2)
Arquivo Brasileiro de Medicina Veterinária e Zootecnia     Open Access   (SJR: 0.292, h-index: 18)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 1, SJR: 0.33, h-index: 29)
Arquivos Brasileiros de Endocrinologia e Metabologia     Open Access   (SJR: 0.329, h-index: 26)
Arquivos Brasileiros de Oftalmologia     Open Access   (SJR: 0.298, h-index: 15)
Arquivos de Gastroenterologia     Open Access   (Followers: 1, SJR: 0.43, h-index: 18)
Arquivos de Medicina     Open Access  
Arquivos de Neuro-Psiquiatria     Open Access   (SJR: 0.357, h-index: 33)
Arquivos do Instituto Biológico     Open Access   (Followers: 1)
Arquivos Internacionais de Otorrinolaringologia     Open Access  
ARS     Open Access   (Followers: 2)
Atenea (Concepción)     Open Access   (SJR: 0.1, h-index: 2)
Atmósfera     Open Access   (Followers: 1, SJR: 0.346, h-index: 13)
Audiology - Communication Research     Open Access   (Followers: 10)
Avaliação : Revista da Avaliação da Educação Superior (Campinas)     Open Access  
Avances en Odontoestomatologia     Open Access   (Followers: 1, SJR: 0.112, h-index: 4)
Avances en Periodoncia e Implantología Oral     Open Access   (Followers: 1)
Bakhtiniana : Revista de Estudos do Discurso     Open Access  
BAR. Brazilian Administration Review     Open Access   (Followers: 1, SJR: 0.165, h-index: 4)
Biocell     Open Access   (SJR: 0.228, h-index: 19)
Biota Neotropica     Open Access   (SJR: 0.437, h-index: 12)
Biotecnología Aplicada     Open Access  
Boletim de Ciências Geodésicas     Open Access   (SJR: 0.202, h-index: 4)
Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas     Open Access   (Followers: 1, SJR: 0.201, h-index: 2)
Boletin Chileno de Parasitologia     Open Access  
Boletín de Filología     Open Access  
Boletín de Historia Argentina y Americana Dr. Emilio Ravignani     Open Access   (Followers: 1)
Boletín de la Sociedad Botánica de México     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Boletín de la Sociedad Geológica Mexicana     Open Access   (SJR: 0.206, h-index: 7)
Boletín del Museo Chileno de Arte Precolombino     Open Access   (Followers: 1)
Bosque     Open Access   (Followers: 2, SJR: 0.245, h-index: 7)
Bragantia     Open Access   (Followers: 2, SJR: 0.685, h-index: 18)
Brazilian Archives of Biology and Technology     Open Access   (Followers: 1, SJR: 0.237, h-index: 24)
Brazilian Dental J.     Open Access   (Followers: 2, SJR: 0.433, h-index: 28)
Brazilian J. of Biology     Open Access   (Followers: 3, SJR: 0.436, h-index: 30)
Brazilian J. of Chemical Engineering     Open Access   (Followers: 3, SJR: 0.437, h-index: 25)
Brazilian J. of Food Technology     Open Access   (Followers: 3)
Brazilian J. of Medical and Biological Research     Open Access   (SJR: 0.431, h-index: 62)
Brazilian J. of Microbiology     Open Access   (Followers: 2, SJR: 0.321, h-index: 31)
Brazilian J. of Oceanography     Open Access   (Followers: 1, SJR: 0.339, h-index: 8)
Brazilian J. of Oral Sciences     Open Access   (Followers: 1, SJR: 0.136, h-index: 5)
Brazilian J. of Physical Therapy     Open Access   (SJR: 0.53, h-index: 12)
Brazilian J. of Plant Physiology     Open Access   (Followers: 3, SJR: 0.243, h-index: 30)
Brazilian J. of Veterinary Research and Animal Science     Open Access   (Followers: 8, SJR: 0.145, h-index: 8)
Brazilian Oral Research     Open Access  
Brazilian Political Science Review     Open Access  
Bulletin of the World Health Organization     Open Access   (Followers: 13, SJR: 2.395, h-index: 105)
Caderno CRH     Open Access   (SJR: 0.209, h-index: 2)
Caderno de Estudos     Open Access  
Cadernos CEDES     Open Access   (Followers: 1, SJR: 0.12, h-index: 4)
Cadernos de Pesquisa     Open Access   (Followers: 2, SJR: 0.314, h-index: 6)
Cadernos de Saúde Pública     Open Access   (Followers: 1, SJR: 0.673, h-index: 45)
Cadernos Metrópole     Open Access  
Cadernos Nietzsche     Open Access  
Cadernos Pagu     Open Access   (SJR: 0.124, h-index: 2)
Cadernos Saúde Coletiva     Open Access   (Followers: 1)
Calidad en la educación     Open Access   (Followers: 1)
Cerâmica     Open Access   (Followers: 3, SJR: 0.198, h-index: 8)
CES Medicina     Open Access  
Chilean J. of Agricultural Research     Open Access   (Followers: 1, SJR: 0.285, h-index: 10)
Chungara (Arica) - Revista de Antropologia Chilena     Open Access   (Followers: 1, SJR: 0.397, h-index: 10)
Ciência & Educação (Bauru)     Open Access  
Ciência & Saúde Coletiva     Open Access   (Followers: 2, SJR: 0.635, h-index: 23)
Ciência Animal Brasileira     Open Access   (SJR: 0.14, h-index: 2)
Ciência da Informação     Open Access   (Followers: 1, SJR: 0.132, h-index: 5)
Ciência e Agrotecnologia     Open Access   (SJR: 0.618, h-index: 14)
Ciencia e Cultura     Open Access   (Followers: 1)
Ciencia e investigación agraria     Open Access   (SJR: 0.196, h-index: 7)
Ciencia forestal en México     Open Access  
Ciência Rural     Open Access   (Followers: 2, SJR: 0.384, h-index: 17)
Ciencia y Enfermeria - Revista Iberoamericana de Investigacion     Open Access   (Followers: 3, SJR: 0.166, h-index: 5)
Ciencias Marinas     Open Access   (Followers: 2, SJR: 0.356, h-index: 17)
Ciencias Psicológicas     Open Access  
Cirugia Plastica Ibero-Latinoamericana     Open Access   (SJR: 0.186, h-index: 7)
CLEI Electronic J.     Open Access  
Clínica y Salud     Open Access  
Clinics     Open Access   (SJR: 0.47, h-index: 29)
CoDAS     Open Access  
Computación y Sistemas     Open Access   (SJR: 0.131, h-index: 2)
Comuni@cción     Open Access  
Comunicación y sociedad     Open Access   (Followers: 2, SJR: 0.363, h-index: 4)
Contaduría y Administración     Open Access  
Contexto Internacional     Open Access  
Convergencia     Open Access   (SJR: 0.119, h-index: 3)
Correo Científico Médico     Open Access  
Corrosão e Protecção de Materiais     Open Access  
Crop Breeding and Applied Biotechnology     Open Access   (Followers: 4, SJR: 0.4, h-index: 10)
Cuaderno urbano     Open Access  
Cuadernos de Economía     Open Access   (Followers: 1)
Cuadernos de Economia - Latin American J. of Economics     Open Access   (Followers: 1)
Cuadernos de Historia     Open Access   (Followers: 3)
Cuadernos de Historia de la Salud Publica     Open Access  
Cuadernos de Medicina Forense     Open Access   (Followers: 2, SJR: 0.102, h-index: 3)
Cuadernos.info     Open Access  
Cubo. A Mathematical J.     Open Access  
Cuicuilco     Open Access   (Followers: 1)
Cultivos Tropicales     Open Access  
Culturales     Open Access   (Followers: 2)
Dados - Revista de Ciências Sociais     Open Access   (SJR: 0.339, h-index: 13)
De Jure     Open Access  
DELTA : Documentação de Estudos em Lingüística Teórica e Aplicada     Open Access   (SJR: 0.108, h-index: 3)
Dementia & Neuropsychologia     Open Access   (Followers: 3)
Dental Press J. of Orthodontics     Open Access   (Followers: 2, SJR: 0.191, h-index: 5)
Desacatos     Open Access   (Followers: 1)
Desarrollo y Sociedad     Open Access   (Followers: 3, SJR: 0.14, h-index: 1)
Diálogo Andino - Revista de Historia, Geografía y Cultura Andina     Open Access  
Diánoia     Open Access   (Followers: 1)
Dimensión Empresarial     Open Access  
Dynamis : Acta Hispanica ad Medicinae Scientiarumque Historiam Illustrandam     Open Access   (Followers: 1)
e-J. of Portuguese History     Open Access   (Followers: 1)
Eclética Química     Open Access   (Followers: 1, SJR: 0.115, h-index: 11)
Ecología en Bolivia     Open Access  
Economia Aplicada     Open Access   (SJR: 0.258, h-index: 4)
Economia e Sociedade     Open Access  
EconoQuantum     Open Access  
Educação & Sociedade     Open Access   (Followers: 2, SJR: 0.394, h-index: 8)
Educação e Pesquisa     Open Access   (SJR: 0.204, h-index: 6)
Educação em Revista     Open Access  
Educación Matemática     Open Access  
Educación Médica     Open Access   (Followers: 1, SJR: 0.109, h-index: 5)
Educación Médica Superior     Open Access   (Followers: 1, SJR: 0.111, h-index: 6)
Educación y Educadores     Open Access   (Followers: 1)
Educar em Revista     Open Access  
EDUMECENTRO     Open Access  
Electronic J. of Biotechnology     Open Access   (Followers: 1, SJR: 0.303, h-index: 30)
En-Claves del pensamiento     Open Access  
Encuentros     Open Access  
Ene : Revista de Enfermería     Open Access  
Enfermería Global     Open Access   (Followers: 3, SJR: 0.113, h-index: 1)
Enfermería Nefrológica     Open Access   (Followers: 1)
Engenharia Agrícola     Open Access   (SJR: 0.505, h-index: 13)
Engenharia Sanitaria e Ambiental     Open Access   (SJR: 0.194, h-index: 7)
Ensaio Avaliação e Políticas Públicas em Educação     Open Access   (Followers: 1, SJR: 0.283, h-index: 4)
Entomologia y Vectores     Open Access   (Followers: 2)
Escritos de Psicología : Psychological Writings     Open Access   (Followers: 1)
Estudios Atacameños     Open Access   (Followers: 2, SJR: 0.172, h-index: 5)
Estudios Constitucionales     Open Access   (Followers: 4, SJR: 0.7, h-index: 3)
Estudios de Cultura Maya     Open Access   (Followers: 3)
Estudios de Economía     Open Access   (SJR: 0.109, h-index: 4)
Estudios de historia moderna y contemporánea de México     Open Access   (SJR: 0.101, h-index: 1)
Estudios Filologicos     Open Access   (SJR: 0.12, h-index: 2)
Estudios Fronterizos     Open Access   (Followers: 1)
Estudios internacionales     Open Access   (Followers: 4)
Estudios Pedagogicos (Valdivia)     Open Access   (Followers: 2, SJR: 0.222, h-index: 4)

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Journal Cover Brazilian Journal of Medical and Biological Research
  [SJR: 0.431]   [H-I: 62]   [0 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0100-879X - ISSN (Online) 1414-431X
   Published by SciELO Homepage  [726 journals]
  • CD19+ B cell subsets in the peripheral blood and skin lesions of psoriasis
           patients and their correlations with disease severity

    • Abstract: T lymphocytes are important in the pathogenesis of psoriasis, and increasing evidence indicates that B cells also play an important role. The mechanisms of action, however, remain unclear. We evaluated the ratios of CD19+ B cells in peripheral blood mononuclear cells (PBMCs) from 157 patients with psoriasis (65 patients with psoriasis vulgaris, 32 patients with erythrodermic psoriasis, 30 patients with arthropathic psoriasis, and 30 patients with pustular psoriasis) and 35 healthy controls (HCs). Ratios of CD19+ B cells in skin lesions were compared with non-lesions in 7 erythrodermic psoriasis patients. The Psoriasis Area Severity Index (PASI) was used to measure disease severity. CD19+ B cell ratios in PBMCs from psoriasis vulgaris (at both the active and stationary stage) and arthropathic psoriasis patients were higher compared with HCs (P<0.01), but ratios were lower in erythrodermic and pustular psoriasis patients (P<0.01). CD19+ B cell ratios in erythrodermic psoriasis skin lesions were higher than in non-lesion areas (P<0.001). Different subsets of CD19+CD40+, CD19+CD44+, CD19+CD80+, CD19+CD86+, CD19+CD11b+, and CD19+HLA-DR+ B cells in PBMCs were observed in different psoriasis clinical subtypes. PASI scores were positively correlated with CD19+ B cell ratios in psoriasis vulgaris and arthropathic psoriasis cases (r=0.871 and r=0.692, respectively, P<0.01), but were negatively correlated in pustular psoriasis (r=-0.569, P<0.01). The results indicated that similar to T cells, B cells activation may also play important roles in different pathological stages of psoriasis.
       
  • Human dental pulp stem cells transplantation combined with treadmill
           training in rats after traumatic spinal cord injury

    • Abstract: Spinal cord injury (SCI) is a disabling condition resulting in deficits of sensory and motor functions, and has no effective treatment. Considering that protocols with stem cell transplantation and treadmill training have shown promising results, the present study evaluated the effectiveness of stem cells from human exfoliated deciduous teeth (SHEDs) transplantation combined with treadmill training in rats with experimental spinal cord injury. Fifty-four Wistar rats were spinalized using NYU impactor. The rats were randomly distributed into 5 groups: Sham (laminectomy with no SCI, n=10); SCI (laminectomy followed by SCI, n=12); SHEDs (SCI treated with SHEDs, n=11); TT (SCI treated with treadmill training, n=11); SHEDs+TT (SCI treated with SHEDs and treadmill training; n=10). Treatment with SHEDs alone or in combination with treadmill training promoted functional recovery, reaching scores of 15 and 14, respectively, in the BBB scale, being different from the SCI group, which reached 11. SHEDs treatment was able to reduce the cystic cavity area and glial scar, increase neurofilament. Treadmill training alone had no functional effectiveness or tissue effects. In a second experiment, the SHEDs transplantation reduced the TNF-α levels in the cord tissue measured 6 h after the injury. Contrary to our hypothesis, treadmill training either alone or in combination, caused no functional improvement. However, SHEDs showed to be neuroprotective, by the reduction of TNF-α levels, the cystic cavity and the glial scar associated with the improvement of motor function after SCI. These results provide evidence that grafted SHEDs might be an effective therapy to spinal cord lesions, with possible anti-inflammatory action.
       
  • Galunisertib (LY2157299), a transforming growth factor-β receptor I
           kinase inhibitor, attenuates acute pancreatitis in rats

    • Abstract: Galunisertib (LY2157299), a selective ATP-mimetic inhibitor of TGF-β receptor I (TGF-βRI), is the only known TGF-β pathway inhibitor. In the present study, we investigated the effect of galunisertib on taurocholate (TAC)-induced acute pancreatitis (AP) in rats, and the role of TGF-β and NF-κB signaling pathways. AP was induced by infusion of TAC into the pancreatic duct of Sprague-Dawley male rats (n=30). The rats (220±50 g) were administered galunisertib intragastrically [75 mg·kg-1·day-1 for 2 days (0 and 24 h)]. Serum IL-1β, IL-6, TNF-α, amylase (AMY), lipase (LIP), and myeloperoxidase (MPO) levels were measured by ELISA. NF-κB activity was detected by electrophoretic mobility shift assay (EMSA); NF-κBp65 and TGF-β1 proteins, as well as TGF-βRI and p-Smad2/3 proteins, were detected by western blot assay. Cell apoptosis was detected by TUNEL assay. H&E staining was used to evaluate the histopathological alterations of the pancreas. Galunisertib treatment attenuated the severity of AP and decreased the pancreatic histological score. In addition, number of apoptotic cells were significantly increased in the galunisertib-treated group (16.38±2.26) than in the AP group (8.14±1.27) and sham-operated group (1.82±0.73; P<0.05 and P<0.01, respectively). Galunisertib decreased the expression levels of TGF-βRI and p-Smad2/3 and inhibited NF-κB activation and p65 translocation compared with the sham-operated group. Furthermore, serum IL-1β, IL-6, TNF-α, AMY and LIP levels and tissue MPO activity were significantly decreased in the galunisertib-treated group. Our data demonstrate that galunisertib attenuates the severity of TAC-induced experimental AP in rats by inducing apoptosis in the pancreas, inhibiting the activation of TGF-β signals and NF-κB as well as the secretion of pro-inflammatory cytokines.
       
  • A review of the application of autologous blood transfusion

    • Abstract: Autologous blood transfusion (ABT) has been gradually attracting more attention due to the increasingly prominent problem of blood transfusion safety and blood shortage in recent years. With the rapid development of blood conservation techniques, blood component separation technology, blood transfusion medicine and a constant increase in clinical needs, ABT technology has been expanded and innovated to a large degree. In this study, the development of preoperative autologous blood donation (PABD), acute normovolemic hemodilution (ANH), intraoperative and postoperative autotransfusion, and other new technologies and theories are reviewed and existing questions are analyzed. Challenges and applications are also discussed in order to provide reference for peers.
       
  • Rosmarinus officinalis L. increases Caenorhabditis
           elegans
    stress resistance and longevity in a DAF-16, HSF-1 and
           SKN-1-dependent manner

    • Abstract: Improving overall health and quality of life, preventing diseases and increasing life expectancy are key concerns in the field of public health. The search for antioxidants that can inhibit oxidative damage in cells has received a lot of attention. Rosmarinus officinalis L. represents an exceptionally rich source of bioactive compounds with pharmacological properties. In the present study, we explored the effects of the ethanolic extract of R. officinalis (eeRo) on stress resistance and longevity using the non-parasitic nematode Caenorhabditis elegans as a model. We report for the first time that eeRo increased resistance against oxidative and thermal stress and extended C. elegans longevity in an insulin/IGF signaling pathway-dependent manner. These data emphasize the eeRo beneficial effects on C. elegans under stress.
       
  • Variability in baseline laboratory measurements of the Brazilian
           Longitudinal Study of Adult Health (ELSA-Brasil)

    • Abstract: Multi-center epidemiological studies must ascertain that their measurements are accurate and reliable. For laboratory measurements, reliability can be assessed through investigation of reproducibility of measurements in the same individual. In this paper, we present results from the quality control analysis of the baseline laboratory measurements from the ELSA-Brasil study. The study enrolled 15,105 civil servants at 6 research centers in 3 regions of Brazil between 2008–2010, with multiple biochemical analytes being measured at a central laboratory. Quality control was ascertained through standard laboratory evaluation of intra- and inter-assay variability and test-retest analysis in a subset of randomly chosen participants. An additional sample of urine or blood was collected from these participants, and these samples were handled in the same manner as the original ones, locally and at the central laboratory. Reliability was assessed with the intraclass correlation coefficient (ICC), estimated through a random effects model. Coefficients of variation (CV) and Bland-Altman plots were additionally used to assess measurement variability. Laboratory intra and inter-assay CVs varied from 0.86% to 7.77%. From test-retest analyses, the ICCs were high for the majority of the analytes. Notably lower ICCs were observed for serum sodium (ICC=0.50; 95%CI=0.31–0.65) and serum potassium (ICC=0.73; 95%CI=0.60–0.83), due to the small biological range of these analytes. The CVs ranged from 1 to 14%. The Bland-Altman plots confirmed these results. The quality control analyses showed that the collection, processing and measurement protocols utilized in the ELSA-Brasil produced reliable biochemical measurements.
       
  • Association of exercise training and angiotensin-converting enzyme 2
           activator improves baroreflex sensitivity of spontaneously hypertensive
           rats

    • Abstract: The present study sought to determine cardiovascular effects of aerobic training associated with diminazene aceturate (DIZE), an activator of the angiotensin converting enzyme 2, in spontaneously hypertensive rats (SHRs). Male SHRs (280–350 g) were either subjected to exercise training or not (sedentary group). The trained group was subjected to 8 weeks of aerobic training on a treadmill (five times a week, lasting 60 min at an intensity of 50–60% of maximum aerobic speed). In the last 15 days of the experimental protocol, these groups were redistributed into four groups: i) sedentary SHRs with daily treatment of 1 mg/kg DIZE (S+D1); ii) trained SHRs with daily treatment of 1 mg/kg DIZE (T+D1); iii) sedentary SHRs with daily treatment of vehicle (S+V); and iv) trained SHRs with daily treatment of vehicle (T+V). After treatment, SHRs were anesthetized and subjected to artery and femoral vein cannulation prior to the implantation of ECG electrode. After 24 h, mean arterial pressure (MAP) and heart rate (HR) were recorded; the baroreflex sensitivity and the effect of double autonomic blockade (DAB) were evaluated in non-anesthetized SHRs. DIZE treatment improved baroreflex sensitivity in the T+D1 group as compared with the T+V and S+D1 groups. The intrinsic heart rate (IHR) and MAP were reduced in T+D1 group as compared with T+V and S+D1 groups. Hence, we conclude that the association of exercise training with DIZE treatment improved baroreflex function and cardiovascular regulation.
       
  • LXW7 ameliorates focal cerebral ischemia injury and attenuates
           inflammatory responses in activated microglia in rats

    • Abstract: Inflammation plays a pivotal role in ischemic stroke, when activated microglia release excessive pro-inflammatory mediators. The inhibition of integrin αvβ3 improves outcomes in rat focal cerebral ischemia models. However, the mechanisms by which microglia are neuroprotective remain unclear. This study evaluated whether post-ischemic treatment with another integrin αvβ3 inhibitor, the cyclic arginine-glycine-aspartic acid (RGD) peptide-cGRGDdvc (LXW7), alleviates cerebral ischemic injury. The anti-inflammatory effect of LXW7 in activated microglia within rat focal cerebral ischemia models was examined. A total of 108 Sprague-Dawley rats (250–280 g) were subjected to middle cerebral artery occlusion (MCAO). After 2 h, the rats were given an intravenous injection of LXW7 (100 μg/kg) or phosphate-buffered saline (PBS). Neurological scores, infarct volumes, brain water content (BWC) and histology alterations were determined. The expressions of pro-inflammatory cytokines [tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β)], and Iba1-positive activated microglia, within peri-ischemic brain tissue, were assessed with ELISA, western blot and immunofluorescence staining. Infarct volumes and BWC were significantly lower in LXW7-treated rats compared to those in the MCAO + PBS (control) group. The LXW7 treatment lowered the expression of pro-inflammatory cytokines. There was a reduction of Iba1-positive activated microglia, and the TNF-α and IL-1β expressions were attenuated. However, there was no difference in the Zea Longa scores between the ischemia and LXW7 groups. The results suggest that LXW7 protected against focal cerebral ischemia and attenuated inflammation in activated microglia. LXW7 may be neuroprotective during acute MCAO-induced brain damage and microglia-related neurodegenerative diseases.
       
  • Investigation on the nasal airflow characteristics of anterior nasal
           cavity stenosis

    • Abstract: We used a computational fluid dynamics (CFD) model to study the inspiratory airflow profiles of patients with anterior nasal cavity stenosis who underwent curative surgery, by comparing pre- and postoperative airflow characteristics. Twenty patients with severe anterior nasal cavity stenosis, including one case of bilateral stenosis, underwent computed tomography (CT) scans for CFD modelling. The pre- and postoperative airflow characteristics of the nasal cavity were simulated and analyzed. The narrowest area of the nasal cavity in all 20 patients was located within the nasal valve area, and the mean cross-sectional area increased from 0.39 cm2 preoperative to 0.78 cm2 postoperative (P<0.01). Meanwhile, the mean airflow velocity in the nasal valve area decreased from 6.19 m/s to 2.88 m/s (P<0.01). Surgical restoration of the nasal symmetry in the bilateral nasal cavity reduced nasal resistance in the narrow sides from 0.24 Pa.s/mL to 0.11 Pa.s/mL (P<0.01). Numerical simulation of the nasal cavity in patients with anterior nasal cavity stenosis revealed structural changes and the resultant patterns of nasal airflow. Surgery achieved balanced bilateral nasal ventilation and decreased nasal resistance in the narrow region of the nasal cavity. The correction of nasal valve stenosis is not only indispensable for reducing nasal resistance, but also the key to obtain satisfactory curative effect.
       
  • Inflammatory and oxidative stress airway markers in premature newborns of
           hypertensive mothers

    • Abstract: Although oxidative stress and inflammation are important mechanisms in the pathophysiology of preeclampsia and preterm diseases, their contribution to the respiratory prognosis of premature infants of hypertensive mothers is not known. Our objective was to determine the levels of oxidative stress and inflammation markers in the airways of premature infants born to hypertensive and normotensive mothers, in the first 72 h of life, and to investigate whether they are predictors of bronchopulmonary dysplasia (BPD)/death. This was a prospective study with premature infants less than 34 weeks’ gestation on respiratory support who were stratified into 2 groups: 32 premature infants of hypertensive mothers and 41 of normotensive women, with a mean gestational age of 29 weeks. Exclusion criteria were as follows: diabetes mellitus, chorioamnionitis, malformation, congenital infection, and death within 24 h after birth. The outcome of interest was BPD/death. Malondialdehyde (MDA), nitric oxide (NO), and interleukin 8 (IL-8) were measured in airway aspirates from the first and third days of life and did not differ between the groups. Univariate and multivariate statistical analyses were performed. The concentrations of MDA, NO, and IL-8 were not predictors of BPD/death. Premature infants who developed BPD/death had higher levels of IL-8 in the first days of life. The gestational age, mechanical ventilation, and a small size for gestational age were risk factors for BPD/death. In conclusion, the biomarkers evaluated were not increased in premature infants of hypertensive mothers and were not predictors of BPD/death.
       
  • Transient elastography and APRI score: looking at false positives and
           false negatives. Diagnostic performance and association to fibrosis
           staging in chronic hepatitis C

    • Abstract: Although long regarded as the gold standard for liver fibrosis staging in chronic hepatitis C (CHC), liver biopsy (LB) implies both the risk of an invasive procedure and significant variability. The aim of this study was to evaluate the diagnostic performance for transient elastography (TE) and aspartate aminotransferase to platelet index (APRI) used alone and in combination compared to liver biopsy and to analyze false positive/negative results. Patients with CHC, and no previous clinical diagnosis of cirrhosis were enrolled to undergo liver biopsy, TE and APRI. A total of 182 adult patients with a median age of 55 years and median body mass index of 26.71 kg/m2 were analyzed. On LB, 56% of patients had significant levels of fibrosis (METAVIR F≥2) and 28% had advanced fibrosis (F3/F4). The strongest performance for both tests was observed for exclusion of advanced fibrosis with good negative predictive values (89 and 86%, respectively). Low necroinflammatory activity on LB was associated with false negative TE. False positives were associated with NASH and smaller LB fragments. Correlation between APRI and Fibroscan for F≥2 was 100% and 84% for F≥3 and remained high in both false negative and false positive instances, correctly identifying F<2 in 71% of cases and F<3 in 78% (and potentially foregoing up to 84% of LB). We concluded that low individual performance indicators could be attributable to limitations of LB. Poorer differentiation of lower levels of fibrosis is a known issue for LB and remains so for noninvasive tests. Good predictability is possible, however, for advanced fibrosis.
       
 
 
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