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Publisher: SciELO   (Total: 717 journals)

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Showing 1 - 200 of 717 Journals sorted alphabetically
ABCD. Arquivos Brasileiros de Cirurgia Digestiva     Open Access   (Followers: 2, SJR: 0.277, h-index: 5)
ACIMED     Open Access   (Followers: 1)
Acta Agronómica     Open Access   (Followers: 1, SJR: 0.11, h-index: 2)
Acta Amazonica     Open Access   (Followers: 5, SJR: 0.32, h-index: 18)
Acta Bioethica     Open Access   (Followers: 1, SJR: 0.131, h-index: 4)
Acta Botanica Brasilica     Open Access   (Followers: 2, SJR: 0.364, h-index: 23)
Acta botánica mexicana     Open Access   (Followers: 1, SJR: 0.251, h-index: 6)
Acta Cirurgica Brasileira     Open Access   (SJR: 0.319, h-index: 19)
Acta Limnologica Brasiliensia     Open Access   (Followers: 3, SJR: 0.29, h-index: 6)
Acta Literaria     Open Access   (Followers: 3, SJR: 0.1, h-index: 2)
Acta Medica Colombiana     Open Access   (Followers: 1)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Neurológica Colombiana     Open Access   (Followers: 1)
Acta Ortopédica Brasileira     Open Access   (Followers: 1, SJR: 0.288, h-index: 10)
Acta Paulista de Enfermagem     Open Access   (Followers: 2, SJR: 0.242, h-index: 15)
Acta Pediátrica Costarricense     Open Access   (Followers: 1)
Acta Scientiarum. Agronomy     Open Access   (Followers: 4, SJR: 0.961, h-index: 15)
Acta zoológica mexicana     Open Access  
Actualidades Biológicas     Open Access   (Followers: 1)
African Human Rights Law J.     Open Access   (Followers: 19)
African Natural History     Open Access   (Followers: 2, SJR: 0.106, h-index: 4)
Afro-Asia     Open Access  
Ágora - studies in psychoanalytic theory     Open Access   (Followers: 3, SJR: 0.101, h-index: 2)
Agricultura Tecnica     Open Access   (Followers: 5)
Agrociencia     Open Access   (Followers: 1, SJR: 0.213, h-index: 15)
Agrociencia Uruguay     Open Access  
Agronomía Mesoamericana     Open Access  
Aisthesis     Open Access   (Followers: 4, SJR: 0.1, h-index: 1)
Alea : Estudos Neolatinos     Open Access   (Followers: 2, SJR: 0.1, h-index: 3)
Alfa : Revista de Linguística     Open Access  
Alpha (Osorno)     Open Access   (SJR: 0.114, h-index: 3)
Ambiente & sociedade     Open Access   (Followers: 2, SJR: 0.142, h-index: 8)
Ambiente & Agua : An Interdisciplinary J. of Applied Science     Open Access   (Followers: 1, SJR: 0.221, h-index: 4)
Ambiente Construído     Open Access   (Followers: 1)
América Latina en la historia económica     Open Access   (Followers: 2, SJR: 0.148, h-index: 1)
Anais Brasileiros de Dermatologia     Open Access   (Followers: 3, SJR: 0.498, h-index: 23)
Anais da Academia Brasileira de Ciências     Open Access   (Followers: 2, SJR: 0.322, h-index: 42)
Anais do Museu Paulista : História e Cultura Material     Open Access   (Followers: 1)
Anales de Medicina Interna     Open Access   (Followers: 1)
Anales del Instituto de la Patagonia     Open Access   (Followers: 1)
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1, SJR: 0.196, h-index: 18)
Análise Psicológica     Open Access   (Followers: 1, SJR: 0.129, h-index: 3)
Análise Social     Open Access   (Followers: 1, SJR: 0.109, h-index: 8)
Andean geology     Open Access   (Followers: 13, SJR: 0.997, h-index: 25)
Annali dell'Istituto Superiore di Sanità     Open Access   (SJR: 0.318, h-index: 29)
Antipoda. Revista de Antropología y Arqueología     Open Access   (Followers: 6, SJR: 0.1, h-index: 0)
Anuario Colombiano de Historia Social y de la Cultura     Open Access   (SJR: 0.101, h-index: 1)
Anuario de Historia Regional y de las Fronteras     Open Access  
Apuntes : Revista de Estudios sobre Patrimonio Cultural - J. of Cultural Heritage Studies     Open Access   (Followers: 4)
Archivos de Medicina Veterinaria     Open Access   (Followers: 1, SJR: 0.199, h-index: 16)
Archivos de Neurociencias     Open Access   (Followers: 3, SJR: 0.1, h-index: 4)
Archivos de Pediatria del Uruguay     Open Access   (Followers: 3)
Archivos de Zootecnia     Open Access   (Followers: 1, SJR: 0.248, h-index: 9)
Archivos Españoles de Urología     Open Access   (SJR: 0.188, h-index: 19)
ARQ     Open Access   (Followers: 4, SJR: 0.1, h-index: 2)
Arquitectura y Urbanismo     Open Access   (Followers: 2)
Arquivo Brasileiro de Medicina Veterinária e Zootecnia     Open Access   (SJR: 0.307, h-index: 22)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 1, SJR: 0.334, h-index: 32)
Arquivos Brasileiros de Endocrinologia e Metabologia     Open Access  
Arquivos Brasileiros de Oftalmologia     Open Access   (SJR: 0.308, h-index: 19)
Arquivos de Gastroenterologia     Open Access   (Followers: 1, SJR: 0.424, h-index: 22)
Arquivos de Medicina     Open Access   (SJR: 0.1, h-index: 5)
Arquivos de Neuro-Psiquiatria     Open Access   (SJR: 0.374, h-index: 38)
Arquivos do Instituto Biológico     Open Access   (Followers: 1)
Arquivos Internacionais de Otorrinolaringologia     Open Access  
ARS     Open Access   (Followers: 2)
Atenea (Concepción)     Open Access   (SJR: 0.111, h-index: 3)
Atmósfera     Open Access   (Followers: 2, SJR: 0.377, h-index: 18)
Audiology - Communication Research     Open Access   (Followers: 8)
Avaliação : Revista da Avaliação da Educação Superior (Campinas)     Open Access  
Avances en Odontoestomatologia     Open Access   (Followers: 1, SJR: 0.109, h-index: 4)
Avances en Periodoncia e Implantología Oral     Open Access   (Followers: 1)
Bakhtiniana : Revista de Estudos do Discurso     Open Access  
BAR. Brazilian Administration Review     Open Access   (Followers: 1, SJR: 0.188, h-index: 6)
Biota Neotropica     Open Access   (SJR: 0.373, h-index: 18)
Biotecnología Aplicada     Open Access   (SJR: 0.122, h-index: 10)
Biotecnología en el Sector Agropecuario y Agroindustrial     Open Access  
Boletim de Ciências Geodésicas     Open Access   (SJR: 0.227, h-index: 5)
Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas     Open Access   (Followers: 1, SJR: 0.139, h-index: 4)
Boletin Chileno de Parasitologia     Open Access  
Boletín de Filología     Open Access  
Boletín de la Sociedad Botánica de México     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Boletín de la Sociedad Geológica Mexicana     Open Access   (SJR: 0.231, h-index: 8)
Boletín del Museo Chileno de Arte Precolombino     Open Access   (Followers: 1, SJR: 0.149, h-index: 1)
Bosque     Open Access   (Followers: 2, SJR: 0.256, h-index: 10)
Bragantia     Open Access   (Followers: 2, SJR: 0.522, h-index: 20)
Brazilian Archives of Biology and Technology     Open Access   (Followers: 3, SJR: 0.242, h-index: 31)
Brazilian Dental J.     Open Access   (Followers: 2, SJR: 0.47, h-index: 34)
Brazilian J. of Biology     Open Access   (Followers: 3, SJR: 0.358, h-index: 35)
Brazilian J. of Chemical Engineering     Open Access   (Followers: 3, SJR: 0.424, h-index: 32)
Brazilian J. of Food Technology     Open Access   (Followers: 3)
Brazilian J. of Medical and Biological Research     Open Access   (SJR: 0.541, h-index: 70)
Brazilian J. of Microbiology     Open Access   (Followers: 3, SJR: 0.39, h-index: 38)
Brazilian J. of Oceanography     Open Access   (Followers: 1, SJR: 0.285, h-index: 13)
Brazilian J. of Oral Sciences     Open Access   (Followers: 1, SJR: 0.145, h-index: 6)
Brazilian J. of Physical Therapy     Open Access   (SJR: 0.466, h-index: 16)
Brazilian J. of Plant Physiology     Open Access   (Followers: 3, SJR: 0.452, h-index: 32)
Brazilian J. of Veterinary Research and Animal Science     Open Access   (Followers: 7, SJR: 0.184, h-index: 10)
Brazilian Oral Research     Open Access  
Brazilian Political Science Review     Open Access  
Bulletin of the World Health Organization     Open Access   (Followers: 17, SJR: 2.819, h-index: 123)
Caderno CRH     Open Access   (SJR: 0.102, h-index: 4)
Caderno de Estudos     Open Access  
Cadernos CEDES     Open Access   (Followers: 1, SJR: 0.111, h-index: 5)
Cadernos de Pesquisa     Open Access   (Followers: 2, SJR: 0.26, h-index: 8)
Cadernos de Saúde Pública     Open Access   (Followers: 1, SJR: 0.593, h-index: 55)
Cadernos de Tradução     Open Access  
Cadernos Metrópole     Open Access   (Followers: 1)
Cadernos Nietzsche     Open Access  
Cadernos Pagu     Open Access   (SJR: 0.179, h-index: 4)
Cadernos Saúde Coletiva     Open Access   (Followers: 1)
Calidad en la educación     Open Access   (Followers: 1)
Cerâmica     Open Access   (Followers: 4, SJR: 0.19, h-index: 11)
CES Medicina     Open Access  
Chilean J. of Agricultural Research     Open Access   (Followers: 1, SJR: 0.366, h-index: 15)
Chungara (Arica) - Revista de Antropologia Chilena     Open Access   (Followers: 1, SJR: 0.49, h-index: 13)
Ciência & Educação (Bauru)     Open Access  
Ciência & Saúde Coletiva     Open Access   (Followers: 2, SJR: 0.588, h-index: 30)
Ciência Animal Brasileira     Open Access   (Followers: 1, SJR: 0.322, h-index: 4)
Ciência da Informação     Open Access   (Followers: 1, SJR: 0.117, h-index: 7)
Ciencia del suelo     Open Access   (Followers: 2, SJR: 0.206, h-index: 13)
Ciência e Agrotecnologia     Open Access   (SJR: 0.444, h-index: 19)
Ciencia e Cultura     Open Access   (Followers: 1)
Ciencia e investigación agraria     Open Access   (Followers: 1, SJR: 0.21, h-index: 10)
Ciencia forestal en México     Open Access  
Ciência Rural     Open Access   (Followers: 2, SJR: 0.389, h-index: 24)
Ciencia y Enfermeria - Revista Iberoamericana de Investigacion     Open Access   (Followers: 3, SJR: 0.165, h-index: 7)
Ciencias Marinas     Open Access   (Followers: 2, SJR: 0.348, h-index: 21)
Ciencias Psicológicas     Open Access  
Cirugia Plastica Ibero-Latinoamericana     Open Access   (SJR: 0.175, h-index: 8)
CLEI Electronic J.     Open Access  
Clínica y Salud     Open Access   (SJR: 0.15, h-index: 3)
Clinics     Open Access   (SJR: 0.525, h-index: 36)
CoDAS     Open Access   (SJR: 0.177, h-index: 12)
Computación y Sistemas     Open Access   (SJR: 0.253, h-index: 4)
Comuni@cción     Open Access  
Comunicación y sociedad     Open Access   (Followers: 2, SJR: 0.104, h-index: 1)
Contaduría y Administración     Open Access   (SJR: 0.103, h-index: 1)
Contexto Internacional     Open Access  
Convergencia     Open Access   (SJR: 0.112, h-index: 4)
Correo Científico Médico     Open Access  
Corrosão e Protecção de Materiais     Open Access  
Crop Breeding and Applied Biotechnology     Open Access   (Followers: 4, SJR: 0.604, h-index: 13)
Cuadernos de Economía     Open Access   (Followers: 2)
Cuadernos de Economia - Latin American J. of Economics     Open Access   (Followers: 2)
Cuadernos de Historia     Open Access   (Followers: 3)
Cuadernos de Historia de la Salud Publica     Open Access  
Cuadernos de Medicina Forense     Open Access   (Followers: 2, SJR: 0.106, h-index: 4)
Cuadernos.info     Open Access   (SJR: 0.117, h-index: 2)
Cubo. A Mathematical J.     Open Access  
Cuicuilco     Open Access   (Followers: 1)
Cultivos Tropicales     Open Access   (Followers: 1)
Culturales     Open Access   (Followers: 2)
Dados - Revista de Ciências Sociais     Open Access   (SJR: 0.429, h-index: 15)
De Jure     Open Access   (Followers: 1)
DELTA : Documentação de Estudos em Lingüística Teórica e Aplicada     Open Access   (SJR: 0.142, h-index: 5)
Dementia & Neuropsychologia     Open Access   (Followers: 6, SJR: 0.232, h-index: 10)
Dental Press J. of Orthodontics     Open Access   (Followers: 2, SJR: 0.214, h-index: 7)
Desacatos     Open Access   (Followers: 1)
Desarrollo y Sociedad     Open Access   (Followers: 3, SJR: 0.106, h-index: 2)
Diálogo Andino - Revista de Historia, Geografía y Cultura Andina     Open Access  
Diánoia     Open Access   (Followers: 1)
Dimensión Empresarial     Open Access  
Dynamis : Acta Hispanica ad Medicinae Scientiarumque Historiam Illustrandam     Open Access   (Followers: 1, SJR: 0.134, h-index: 7)
e-J. of Portuguese History     Open Access   (Followers: 2, SJR: 0.125, h-index: 2)
Eclética Química     Open Access   (Followers: 1)
Ecología en Bolivia     Open Access  
Economia Aplicada     Open Access   (SJR: 0.168, h-index: 6)
Economia e Sociedade     Open Access  
EconoQuantum     Open Access  
Educação & Sociedade     Open Access   (Followers: 3, SJR: 0.244, h-index: 12)
Educação e Pesquisa     Open Access   (Followers: 1, SJR: 0.171, h-index: 8)
Educação em Revista     Open Access  
Educación Matemática     Open Access  
Educación Médica     Open Access   (Followers: 1, SJR: 0.11, h-index: 7)
Educación Médica Superior     Open Access   (Followers: 1, SJR: 0.188, h-index: 7)
Educación y Educadores     Open Access   (Followers: 1)
Educar em Revista     Open Access  
EDUMECENTRO     Open Access  
En-Claves del pensamiento     Open Access   (Followers: 1)
Encuentros     Open Access  
Ene : Revista de Enfermería     Open Access  
Enfermería Global     Open Access   (Followers: 3, SJR: 0.14, h-index: 2)
Enfermería Nefrológica     Open Access   (Followers: 1)
Engenharia Agrícola     Open Access   (SJR: 0.396, h-index: 18)
Engenharia Sanitaria e Ambiental     Open Access   (SJR: 0.15, h-index: 10)
Ensaio Avaliação e Políticas Públicas em Educação     Open Access   (Followers: 1, SJR: 0.19, h-index: 6)
Entomologia y Vectores     Open Access   (Followers: 2)
Escritos de Psicología : Psychological Writings     Open Access   (Followers: 2)
Estudios Atacameños     Open Access   (Followers: 2, SJR: 0.418, h-index: 8)
Estudios Constitucionales     Open Access   (Followers: 4, SJR: 0.383, h-index: 5)
Estudios de Cultura Maya     Open Access   (Followers: 3, SJR: 0.167, h-index: 1)
Estudios de Economía     Open Access   (SJR: 0.144, h-index: 7)
Estudios de historia moderna y contemporánea de México     Open Access   (SJR: 0.101, h-index: 3)
Estudios Filologicos     Open Access   (SJR: 0.105, h-index: 3)
Estudios Fronterizos     Open Access   (Followers: 1)
Estudios internacionales     Open Access   (Followers: 5)
Estudios Pedagogicos (Valdivia)     Open Access   (Followers: 2, SJR: 0.209, h-index: 7)
Estudios Políticos     Open Access  

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Journal Cover Acta Cirurgica Brasileira
  [SJR: 0.319]   [H-I: 19]   [0 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0102-8650 - ISSN (Online) 1678-2674
   Published by SciELO Homepage  [717 journals]
  • Continuous versus interrupted suture technique in microvascular
           anastomosis in rats

    • Abstract: Purpose: To compare the continuous and interrupted suture technique on femoral artery on rats after vessel repair and 14 days after. Methods: Twenty rats were operated randomly divided into two group matched according to the suture technique used: interrupted or continuous. We performed a femoral anastomosis on the right femoral artery. We analyzed weight, arterial caliber, anastomosis time and patency after vessel repair and 14 days after. Results: There was no significant difference between groups in the weight (p=0.64), diameter of the femoral artery (p=0.95) and patency (p=1.00). The time spent in the anastomosis was 451 seconds in the continuous group and 718 seconds in the interrupted group, presenting significant difference (p<0.01). Conclusion: The continuous suture technique shows a similar patency rates than interrupted technique, however with a shorter time to perform the anastomosis.
       
  • End-to-side versus end-to-end neurorrhaphy at the peroneal nerve
           in rats

    • Abstract: Purpose: To evaluate three different kinds of neurorrhaphy of the peroneal nerve. Methods: Eigthy rats were divided into 5 groups. Control: nerve had no intervention. End-to-end (EE): nerve was cut and elongated with a nerve graft with two end-to-end neurorrhaphies. End-to-side (ES): nerve was cut and sutured to the graft with at the lateral side of the nerve. Side-to-end (SE): the nerve was cut and sutured to the graft with end-to-end neurorrhaphy. Denervated: nerve was cut and both endings were buried into the muscle. The evaluation was done by walking track analysis, electrophysiology, body mass, cranial tibial muscle mass, nerve and muscle fibers morphometry. Results: The EE, ES and SE have the same potential of reinnervation. Conclusion: There is no functional or histological difference between these different types of neurorrhaphy.
       
  • Ultrastructural analysis and residual DNA evaluation of rabbit vein
           scaffold

    • Abstract: Purpose: To investigate the ultrastructural characteristics and analysis of residual DNA in scaffold models, produced with decellularized vena cava in an experimental model with rabbits. Methods: Three groups were created for ultrastructural and residual DNA analysis: group 1 - control, consisting of samples of vena cava in natura; group 2 - SD, consisting of vein fragments submitted to 2% sodium deoxycholate decellularization by shaking (160rpm - Shaker News Brunswick Scientific®) for 1 hour at controlled temperature shaker at 37°C; group 3 - SDS, consisting of vein fragments submitted to 1% sodium dodecyl sulfate decellularization under the same previous condition, for 2 hours. Results: The ultrastructural matrix of the blood vessel maintained its vintegrity after either decellularization models. The results of the two quantification methods demonstrated a significant decrease in the DNA content of the decellularized vena cava samples as compared to the control samples and, differed statistically from each other, p <0.05. Conclusion: The 2% DS protocol for vein decellularization, in this experimental model, was considered the best protocol because it presented less amount of residual DNA without causing substantial destruction of the extracellular matrix.
       
  • Role of the route of leukotrienes in an experimental model of oral
           mucositis induced by 5-fluorouracil

    • Abstract: Purpose: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. Methods: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i.p., on days 1 and 2, respectively, and with excoriations in jugal mucosa on day 4). Montelukast (10, 20, or 40 mg/kg/d; gavage), MK886 (3 mg/kg/d, i.p.), or saline or celecoxib (7.5 mg/kg/d; i.p.) was administered 1 h prior to 5-FU and daily, until the fourth (MK886) or tenth day, when the animals were euthanized and their jugal mucosa was collected for macroscopic, histopathological, and immunohistochemical evaluation. Results: Neither montelukast nor MK-886 prevented the oral mucositis induced by 5-FU, as observed by histopathological evaluation. In addition, we did not find significant differences in the expression of inducible nitric oxide synthase-2, cyclooxygenase-2, or interleukin (IL)-1β between the experimental and control groups. However, we did observe a significant decrease in tumor necrosis factor (TNF)-α expression for all doses of montelukast; we also observed a significant decrease in IL-10 with 40 mg/kg/d and MK 886. Conclusions: Cysteinyl leukotrienes do not play an important role in experimental oral mucositis induced by 5-FU. There is a modulating action specifically on TNF-α.
       
  • Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates
           inflammatory responses in cutaneous wound healing in mice

    • Abstract: Purpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. Methods: The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/vaseline base), or STRO- treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure rate; the inflammation was evaluated by leukocytes accumulation and cytokine levels in the wounds. The accumulation of neutrophil and macrophages in the wounds were determined by assaying myeloperoxidase and N-acetyl-β-D-glucosaminidase activities. The levels of TNF-α, CXCL-1 and CCL-2 in wound were evaluated by ELISA assay. Angiogenesis and collagen fibers deposition were evaluated histologically. Results: We observed that macroscopic wound closure rate was improved in wounds from STRO-group than Control-group. The wounds treated with STRO promoted a reduction in leucocyte accumulation and in pro-inflammatory cytokine. Moreover, STRO treatment increased significantly the number of blood vessels and collagen fibers deposition, as compared to control group. Conclusion: Topical application of STRO display anti-inflammatory and angiogenic effects, as well as improvement in collagen replacement, suggesting a putative use of this herb for the development of phytomedicines to treat inflammatory diseases, including wound healing.
       
  • X-ray dynamic observation of cervical degenerative disease induced by
           unbalanced dynamic and static forces in rats

    • Abstract: Purpose: To investigate dynamically the X-ray appearance of cervical degenerative disease induced by unbalanced dynamic and static forces in rats. Methods: A total of 60 Sprague Dawley rats were randomized into test (n=45) and control (n=15) groups, which were randomly subdivided into the one-, three- and six-month post-operative groups. The test group included 10, 15 and 20 rats at the respective corresponding post-operative stage and the control group included five rats at each time-point. By excising cervicodorsal muscles, interspinous ligaments and supraspinous ligament of rats in the test group, the balance of dynamic and static forces on cervical vertebrae was disrupted to establish a rat model of cervical degeneration. Spinal X-ray images were acquired, and intervertebral disc space and intervertebral foramen size were measured at one, three and six months post-operation. The results were analyzed and compared among groups. Results: Cervical dynamic and static imbalance accelerated the appearance of cervical degenerative disease on X-ray. Conclusion: Cervical degenerative disease may be induced by unbalanced dynamic and static forces in rats.
       
  • The influence of allopurinol and post-conditioning on lung injuries
           induced by lower-limb ischemia and reperfusion in Wistar rats

    • Abstract: Purpose: To analyze the effects of allopurinol and of post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion. Methods: Thirty rats were used. They were divided in 5 groups: (1) group A: abdominal aortic dissection only, (2) group B: ischemia and reperfusion, (3) group C: administered allopurinol (100mg/Kg) a few hours before procedure, (4) group D: post-conditioned and (5) group E: administered allopurinol and post-conditioned. With the exception of group A, all groups were submitted to infrarenal aortic ischemia for 2 hours, and reperfusion for 72 hours. After euthanasia, lungs were removed for histological analysis. They were graded under two scores: pulmonary injury (neutrophil infiltration, interstitial edema, vascular congestion, and destruction of lung architecture) and lymphocytic score (neutrophil infiltration, lymphoid aggregate and secondary follicle). Results: On the pulmonary injury score, the degree of injury was smaller than in groups D and E, when compared to group B, p<0.05. Group C did not obtain the same result (p>0,05). On the lymphocytic score, there was no statistic difference among groups, p>0.05. Conclusion: Both post-conditioning and the combination of allopurinol and post-conditioning were effective in remote lung protection induced by lower-limbs I/R. When used in isolation, allopurinol showed no protective effect.
       
  • Effects of folic acid administration on testicular ischemia/reperfusion
           injury in rats

    • Abstract: Purpose: To determine the effect of folic acid (FA) on experimental testicular ischemia/reperfusion (I/R) in rats. Methods: Sixty male Wistar rats were randomly divided into 6 groups. The control group received physiologic saline orally. The sham-operated group received physiologic saline orally then exposed to midline laparotomy without clamping the IR. The I/R rats received oral gavage of the saline then subjected to 1h ischemia /24h reperfusion, period. In folic acid (2mg/kg+IR) rats received oral gavage of the FA (2mg/kg) then subjected to 1h I/24h R. groups 5-6 received FA (5 and 10 mg/kg), then subjected to 1 h I/24 h, respectively. At the end of the study, semen samples were collected for spermatozoa characteristics. The left testis was removed for histological analysis and superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione peroxidase (GPx) measurement. Results: Spermatozoa mobility, mortality (%) significantly decreased in I/R group (P<0.05). Dose dependent increase observed on spermatozoa mobility, mortality (%) using different levels of the FA (2, 5 and 10 mg/kg) treated rat (P<0.05). Tissue MDA levels significantly increased in I/R rat (P<0.05) while FA (2, 5 and 10mg/kg) in a dose dependent manner decreased I/R-induced MDA (P<0.05). Experimental I/R significantly decreased SOD and GPx activity (P<0.05). Administration of the FA (2, 5 and 10mg/kg) significantly increased tissue SOD and GPx activity in I/R rat (P<0.05). Seminiferous tubules degenerated and loss of spermatogenesis with few spermatocytes was observed in degenerated testis tubules in I/R rat. Orally administration of the FA (5 and 10 mg/kg) improved testis characteristics with few normal seminiferous tubules and spermatocyte in seminiferous tubules in experimental I/R-induced rat. Conclusion: The treatment of folic acid had a benefit effect against ischemia-reperfusion.
       
  • Allogeneic mesenchymal stem cells and xenogenic platelet rich plasma,
           associated or not, in the repair of bone failures in rabbits with
           secondary osteoporosis

    • Abstract: Purpose: To assess the efficacy of allogeneic mesenchymal stem cells and xenogenic platelet rich plasma in the treatment of bone failure of osteoporotic rabbits secondary to estrogenic deprivation and iatrogenic hypercortisolism. Methods: Eight female rabbits underwent ovarian resection and corticoid therapy to induce clinical status of osteoporosis. Four failures were produced in the tibiae, with each failure being treated with hemostatic sponge, allogenic mesenchymal stem cells, xenogenic platelet-rich plasma and the association between both. The animals were divided into two groups, evaluated radiographically and histopathologically at 30 and 60 days post treatment. Results: A radiographically confirmed consolidation of bone failures treated with allogeneic mesenchymal stem cells, associated with the histopathological image of mature and immature bone tissue, without evidence of osteopenia, was compared with the other groups, in which radiolucent failures with osteopenia and fibrosis were still present, denoting the satisfactory effect of the first treatment in detriment to the others. Conclusion: The treatment of bone failures of rabbits with secondary osteoporosis with allogeneic mesenchymal stem cells induced greater bone consolidation with mature and immature bone tissue production (p<0.01), when compared to the other treatments.
       
  • Effects of local alendronate administration on bone defect healing.
           Histomorphometric and radiological evaluation in a rabbit model

    • Abstract: Purpose: To performed a histomorphometric and radiological study to evaluate the effects of alendronate sodium administered locally in mandibular bone defects created in rabbits. Methods: Two circular defects 5 mm in diameter were created bilaterally in the mandibular corpus of 20 New Zealand rabbits (i.e., four defects per animal). Each defect received one of four treatments: no treatment (EC group), alendronate irrigation (AL group), autogenous bone grafting (AG group), or alendronate irrigation with autogenous bone grafting (AL+AG group). Histomorphometric and radiological assessments were conducted at 4 and 8 weeks after surgery. Results: Between-group comparisons of the new bone area, the value of the AL+AG group was significantly lower thanthe remaining three groups at 4 weeks postoperatively. In all groups, the new bone area was significantly larger at 8 weeks than at 4 weeks. The residual graft area at 4 and 8 weeks was significantly higher in the AL+AG group than in the AG group, although it was significantly smaller at 8 weeks than at 4 weeks in both these groups. Conclusion: The use of alendronate sodium in conjunction with autogenous bone grafting improves the osteoconductive properties of the graft, enhances graft retention in the defect, and improves ossification.
       
 
 
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