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Publisher: Sage Publications   (Total: 1074 journals)

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Showing 1 - 200 of 1074 Journals sorted alphabetically
AADE in Practice     Hybrid Journal   (Followers: 5)
Abstracts in Anthropology     Full-text available via subscription   (Followers: 20)
Academic Pathology     Open Access   (Followers: 3)
Accounting History     Hybrid Journal   (Followers: 17, SJR: 0.527, CiteScore: 1)
Acta Radiologica     Hybrid Journal   (Followers: 2, SJR: 0.754, CiteScore: 2)
Acta Radiologica Open     Open Access   (Followers: 3)
Acta Sociologica     Hybrid Journal   (Followers: 36, SJR: 0.939, CiteScore: 2)
Action Research     Hybrid Journal   (Followers: 48, SJR: 0.308, CiteScore: 1)
Active Learning in Higher Education     Hybrid Journal   (Followers: 322, SJR: 1.397, CiteScore: 2)
Adaptive Behavior     Hybrid Journal   (Followers: 10, SJR: 0.288, CiteScore: 1)
Administration & Society     Hybrid Journal   (Followers: 14, SJR: 0.675, CiteScore: 1)
Adoption & Fostering     Hybrid Journal   (Followers: 22, SJR: 0.313, CiteScore: 0)
Adsorption Science & Technology     Open Access   (Followers: 7, SJR: 0.258, CiteScore: 1)
Adult Education Quarterly     Hybrid Journal   (Followers: 192, SJR: 0.566, CiteScore: 2)
Adult Learning     Hybrid Journal   (Followers: 39)
Advances in Dental Research     Hybrid Journal   (Followers: 6, SJR: 1.791, CiteScore: 4)
Advances in Developing Human Resources     Hybrid Journal   (Followers: 29, SJR: 0.614, CiteScore: 2)
Advances in Mechanical Engineering     Open Access   (Followers: 131, SJR: 0.272, CiteScore: 1)
Advances in Methods and Practices in Psychological Science     Full-text available via subscription   (Followers: 9)
Advances in Structural Engineering     Full-text available via subscription   (Followers: 46, SJR: 0.599, CiteScore: 1)
Advances in Tumor Virology     Open Access   (Followers: 3, SJR: 0.108, CiteScore: 0)
AERA Open     Open Access   (Followers: 8)
Affilia     Hybrid Journal   (Followers: 4, SJR: 0.496, CiteScore: 1)
Agrarian South : J. of Political Economy     Hybrid Journal   (Followers: 2)
Air, Soil & Water Research     Open Access   (Followers: 14, SJR: 0.214, CiteScore: 1)
Alexandria : The J. of National and Intl. Library and Information Issues     Full-text available via subscription   (Followers: 63)
AlterNative : An Intl. J. of Indigenous Peoples     Full-text available via subscription   (Followers: 11, SJR: 0.194, CiteScore: 0)
Alternative Law J.     Hybrid Journal   (Followers: 9, SJR: 0.176, CiteScore: 0)
Alternatives : Global, Local, Political     Hybrid Journal   (Followers: 12, SJR: 0.351, CiteScore: 1)
American Behavioral Scientist     Hybrid Journal   (Followers: 21, SJR: 0.982, CiteScore: 2)
American Economist     Hybrid Journal   (Followers: 5)
American Educational Research J.     Hybrid Journal   (Followers: 191, SJR: 2.913, CiteScore: 3)
American J. of Alzheimer's Disease and Other Dementias     Hybrid Journal   (Followers: 19, SJR: 0.67, CiteScore: 2)
American J. of Cosmetic Surgery     Hybrid Journal   (Followers: 6)
American J. of Evaluation     Hybrid Journal   (Followers: 17, SJR: 0.646, CiteScore: 2)
American J. of Health Promotion     Hybrid Journal   (Followers: 30, SJR: 0.807, CiteScore: 1)
American J. of Hospice and Palliative Medicine     Hybrid Journal   (Followers: 40, SJR: 0.65, CiteScore: 1)
American J. of Law & Medicine     Full-text available via subscription   (Followers: 11, SJR: 0.204, CiteScore: 1)
American J. of Lifestyle Medicine     Hybrid Journal   (Followers: 5, SJR: 0.431, CiteScore: 1)
American J. of Medical Quality     Hybrid Journal   (Followers: 10, SJR: 0.777, CiteScore: 1)
American J. of Men's Health     Open Access   (Followers: 8, SJR: 0.595, CiteScore: 2)
American J. of Rhinology and Allergy     Hybrid Journal   (Followers: 9, SJR: 0.972, CiteScore: 2)
American J. of Sports Medicine     Hybrid Journal   (Followers: 182, SJR: 3.949, CiteScore: 6)
American Politics Research     Hybrid Journal   (Followers: 34, SJR: 1.313, CiteScore: 1)
American Review of Public Administration     Hybrid Journal   (Followers: 18, SJR: 2.062, CiteScore: 2)
American Sociological Review     Hybrid Journal   (Followers: 289, SJR: 6.333, CiteScore: 6)
American String Teacher     Full-text available via subscription   (Followers: 2)
Analytical Chemistry Insights     Open Access   (Followers: 25, SJR: 0.224, CiteScore: 1)
Angiology     Hybrid Journal   (Followers: 3, SJR: 0.849, CiteScore: 2)
Animation     Hybrid Journal   (Followers: 13, SJR: 0.197, CiteScore: 0)
Annals of Clinical Biochemistry     Hybrid Journal   (Followers: 9, SJR: 0.634, CiteScore: 1)
Annals of Otology, Rhinology & Laryngology     Hybrid Journal   (Followers: 15, SJR: 0.807, CiteScore: 1)
Annals of Pharmacotherapy     Hybrid Journal   (Followers: 50, SJR: 1.096, CiteScore: 2)
Annals of the American Academy of Political and Social Science     Hybrid Journal   (Followers: 46, SJR: 1.225, CiteScore: 3)
Annals of the ICRP     Hybrid Journal   (Followers: 4, SJR: 0.548, CiteScore: 1)
Anthropocene Review     Hybrid Journal   (Followers: 9, SJR: 3.341, CiteScore: 7)
Anthropological Theory     Hybrid Journal   (Followers: 41, SJR: 0.739, CiteScore: 1)
Antitrust Bulletin     Full-text available via subscription   (Followers: 10)
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 2, SJR: 0.635, CiteScore: 2)
Antyajaa : Indian J. of Women and Social Change     Hybrid Journal  
Applied Biosafety     Hybrid Journal   (SJR: 0.131, CiteScore: 0)
Applied Psychological Measurement     Hybrid Journal   (Followers: 22, SJR: 1.17, CiteScore: 1)
Applied Spectroscopy     Full-text available via subscription   (Followers: 26, SJR: 0.489, CiteScore: 2)
Armed Forces & Society     Hybrid Journal   (Followers: 16, SJR: 0.29, CiteScore: 1)
Arts and Humanities in Higher Education     Hybrid Journal   (Followers: 38, SJR: 0.305, CiteScore: 1)
Asia Pacific Media Educator     Hybrid Journal   (Followers: 1, SJR: 0.23, CiteScore: 0)
Asia-Pacific J. of Management Research and Innovation     Full-text available via subscription   (Followers: 3)
Asia-Pacific J. of Public Health     Hybrid Journal   (Followers: 9, SJR: 0.558, CiteScore: 1)
Asian and Pacific Migration J.     Full-text available via subscription   (Followers: 91, SJR: 0.324, CiteScore: 1)
Asian Cardiovascular and Thoracic Annals     Hybrid Journal   (Followers: 2, SJR: 0.305, CiteScore: 0)
Asian J. of Comparative Politics     Hybrid Journal   (Followers: 4)
Asian J. of Legal Education     Full-text available via subscription   (Followers: 4)
Asian J. of Management Cases     Hybrid Journal   (Followers: 6, SJR: 0.101, CiteScore: 0)
ASN Neuro     Open Access   (Followers: 2, SJR: 1.534, CiteScore: 3)
Assessment     Hybrid Journal   (Followers: 15, SJR: 1.519, CiteScore: 3)
Assessment for Effective Intervention     Hybrid Journal   (Followers: 15, SJR: 0.578, CiteScore: 1)
Australasian Psychiatry     Hybrid Journal   (Followers: 9, SJR: 0.433, CiteScore: 1)
Australian & New Zealand J. of Psychiatry     Hybrid Journal   (Followers: 18, SJR: 1.801, CiteScore: 2)
Australian and New Zealand J. of Criminology     Hybrid Journal   (Followers: 520, SJR: 0.612, CiteScore: 1)
Australian J. of Career Development     Hybrid Journal   (Followers: 3)
Australian J. of Education     Hybrid Journal   (Followers: 41, SJR: 0.403, CiteScore: 1)
Australian J. of Management     Hybrid Journal   (Followers: 12, SJR: 0.497, CiteScore: 1)
Autism     Hybrid Journal   (Followers: 304, SJR: 1.739, CiteScore: 4)
Autism & Developmental Language Impairments     Open Access   (Followers: 9)
Behavior Modification     Hybrid Journal   (Followers: 11, SJR: 0.877, CiteScore: 2)
Behavioral and Cognitive Neuroscience Reviews     Hybrid Journal   (Followers: 25)
Bible Translator     Hybrid Journal   (Followers: 12)
Biblical Theology Bulletin     Hybrid Journal   (Followers: 18, SJR: 0.184, CiteScore: 0)
Big Data & Society     Open Access   (Followers: 47)
Biochemistry Insights     Open Access   (Followers: 7)
Bioinformatics and Biology Insights     Open Access   (Followers: 11, SJR: 1.141, CiteScore: 2)
Biological Research for Nursing     Hybrid Journal   (Followers: 7, SJR: 0.685, CiteScore: 2)
Biomarker Insights     Open Access   (Followers: 1, SJR: 0.81, CiteScore: 2)
Biomarkers in Cancer     Open Access   (Followers: 10)
Biomedical Engineering and Computational Biology     Open Access   (Followers: 13)
Biomedical Informatics Insights     Open Access   (Followers: 8)
Bioscope: South Asian Screen Studies     Hybrid Journal   (Followers: 3, SJR: 0.235, CiteScore: 0)
BMS: Bulletin of Sociological Methodology/Bulletin de Méthodologie Sociologique     Hybrid Journal   (Followers: 3, SJR: 0.226, CiteScore: 0)
Body & Society     Hybrid Journal   (Followers: 26, SJR: 1.531, CiteScore: 3)
Bone and Tissue Regeneration Insights     Open Access   (Followers: 2)
Breast Cancer : Basic and Clinical Research     Open Access   (Followers: 8, SJR: 0.823, CiteScore: 2)
British J. of Music Therapy     Hybrid Journal   (Followers: 8)
British J. of Occupational Therapy     Hybrid Journal   (Followers: 169, SJR: 0.323, CiteScore: 1)
British J. of Pain     Hybrid Journal   (Followers: 26, SJR: 0.579, CiteScore: 2)
British J. of Politics and Intl. Relations     Hybrid Journal   (Followers: 31, SJR: 0.91, CiteScore: 2)
British J. of Visual Impairment     Hybrid Journal   (Followers: 13, SJR: 0.337, CiteScore: 1)
British J.ism Review     Hybrid Journal   (Followers: 17)
Building Acoustics     Hybrid Journal   (Followers: 4, SJR: 0.215, CiteScore: 1)
Building Services Engineering Research & Technology     Hybrid Journal   (Followers: 3, SJR: 0.583, CiteScore: 1)
Bulletin of Science, Technology & Society     Hybrid Journal   (Followers: 7)
Business & Society     Hybrid Journal   (Followers: 12)
Business and Professional Communication Quarterly     Hybrid Journal   (Followers: 7, SJR: 0.348, CiteScore: 1)
Business Information Review     Hybrid Journal   (Followers: 15, SJR: 0.279, CiteScore: 0)
Business Perspectives and Research     Hybrid Journal   (Followers: 2)
Cahiers Élisabéthains     Hybrid Journal   (Followers: 1, SJR: 0.111, CiteScore: 0)
Calcutta Statistical Association Bulletin     Full-text available via subscription  
California Management Review     Hybrid Journal   (Followers: 30, SJR: 2.209, CiteScore: 4)
Canadian J. of Kidney Health and Disease     Open Access   (Followers: 6, SJR: 1.007, CiteScore: 2)
Canadian J. of Nursing Research (CJNR)     Hybrid Journal   (Followers: 13)
Canadian J. of Occupational Therapy     Hybrid Journal   (Followers: 121, SJR: 0.626, CiteScore: 1)
Canadian J. of Psychiatry     Hybrid Journal   (Followers: 26, SJR: 1.769, CiteScore: 3)
Canadian J. of School Psychology     Hybrid Journal   (Followers: 11, SJR: 0.266, CiteScore: 1)
Canadian Pharmacists J. / Revue des Pharmaciens du Canada     Hybrid Journal   (Followers: 3, SJR: 0.536, CiteScore: 1)
Cancer Growth and Metastasis     Open Access   (Followers: 1)
Cancer Informatics     Open Access   (Followers: 4, SJR: 0.64, CiteScore: 1)
Capital and Class     Hybrid Journal   (Followers: 7, SJR: 0.282, CiteScore: 1)
Cardiac Cath Lab Director     Full-text available via subscription  
Cardiovascular and Thoracic Open     Open Access  
Career Development and Transition for Exceptional Individuals     Hybrid Journal   (Followers: 8, SJR: 0.44, CiteScore: 1)
Cartilage     Hybrid Journal   (Followers: 5, SJR: 0.889, CiteScore: 3)
Cell and Tissue Transplantation and Therapy     Open Access   (Followers: 2)
Cell Transplantation     Open Access   (Followers: 4, SJR: 1.023, CiteScore: 3)
Cephalalgia     Hybrid Journal   (Followers: 7, SJR: 1.581, CiteScore: 3)
Child Language Teaching and Therapy     Hybrid Journal   (Followers: 31, SJR: 0.501, CiteScore: 1)
Child Maltreatment     Hybrid Journal   (Followers: 9, SJR: 1.22, CiteScore: 3)
Child Neurology Open     Open Access   (Followers: 6)
Childhood     Hybrid Journal   (Followers: 18, SJR: 0.894, CiteScore: 2)
Childhood Obesity and Nutrition     Open Access   (Followers: 11)
China Information     Hybrid Journal   (Followers: 7, SJR: 0.767, CiteScore: 2)
China Report     Hybrid Journal   (Followers: 10, SJR: 0.221, CiteScore: 0)
Chinese J. of Sociology     Full-text available via subscription   (Followers: 4)
Christianity & Literature     Full-text available via subscription   (Followers: 7)
Chronic Illness     Hybrid Journal   (Followers: 7, SJR: 0.672, CiteScore: 2)
Chronic Respiratory Disease     Hybrid Journal   (Followers: 6, SJR: 0.808, CiteScore: 2)
Chronic Stress     Open Access  
Citizenship, Social and Economics Education     Full-text available via subscription   (Followers: 6, SJR: 0.145, CiteScore: 0)
Cleft Palate-Craniofacial J.     Hybrid Journal   (Followers: 7, SJR: 0.757, CiteScore: 1)
Clin-Alert     Hybrid Journal   (Followers: 1)
Clinical and Applied Thrombosis/Hemostasis     Open Access   (Followers: 15, SJR: 0.49, CiteScore: 1)
Clinical Case Studies     Hybrid Journal   (Followers: 3, SJR: 0.364, CiteScore: 1)
Clinical Child Psychology and Psychiatry     Hybrid Journal   (Followers: 43, SJR: 0.73, CiteScore: 2)
Clinical EEG and Neuroscience     Hybrid Journal   (Followers: 5, SJR: 0.552, CiteScore: 2)
Clinical Ethics     Hybrid Journal   (Followers: 10, SJR: 0.296, CiteScore: 1)
Clinical Medicine Insights : Arthritis and Musculoskeletal Disorders     Open Access   (Followers: 3, SJR: 0.537, CiteScore: 2)
Clinical Medicine Insights : Blood Disorders     Open Access   (SJR: 0.314, CiteScore: 2)
Clinical Medicine Insights : Cardiology     Open Access   (Followers: 6, SJR: 0.686, CiteScore: 2)
Clinical Medicine Insights : Case Reports     Open Access   (Followers: 1, SJR: 0.283, CiteScore: 1)
Clinical Medicine Insights : Circulatory, Respiratory and Pulmonary Medicine     Open Access   (Followers: 3, SJR: 0.425, CiteScore: 2)
Clinical Medicine Insights : Ear, Nose and Throat     Open Access   (Followers: 1)
Clinical Medicine Insights : Endocrinology and Diabetes     Open Access   (Followers: 32, SJR: 0.63, CiteScore: 2)
Clinical Medicine Insights : Gastroenterology     Open Access   (Followers: 3, SJR: 0.775, CiteScore: 2)
Clinical Medicine Insights : Oncology     Open Access   (Followers: 3, SJR: 1.129, CiteScore: 3)
Clinical Medicine Insights : Pediatrics     Open Access   (Followers: 3)
Clinical Medicine Insights : Psychiatry     Open Access   (Followers: 9)
Clinical Medicine Insights : Reproductive Health     Open Access   (Followers: 2, SJR: 0.776, CiteScore: 0)
Clinical Medicine Insights : Therapeutics     Open Access   (Followers: 1, SJR: 0.172, CiteScore: 0)
Clinical Medicine Insights : Trauma and Intensive Medicine     Open Access   (Followers: 4)
Clinical Medicine Insights : Urology     Open Access   (Followers: 2)
Clinical Medicine Insights : Women's Health     Open Access   (Followers: 4)
Clinical Nursing Research     Hybrid Journal   (Followers: 31, SJR: 0.471, CiteScore: 1)
Clinical Pathology     Open Access   (Followers: 2)
Clinical Pediatrics     Hybrid Journal   (Followers: 23, SJR: 0.487, CiteScore: 1)
Clinical Psychological Science     Hybrid Journal   (Followers: 12, SJR: 3.281, CiteScore: 5)
Clinical Rehabilitation     Hybrid Journal   (Followers: 68, SJR: 1.322, CiteScore: 3)
Clinical Risk     Hybrid Journal   (Followers: 5, SJR: 0.133, CiteScore: 0)
Clinical Trials     Hybrid Journal   (Followers: 19, SJR: 2.399, CiteScore: 2)
Clothing and Textiles Research J.     Hybrid Journal   (Followers: 23, SJR: 0.36, CiteScore: 1)
Common Law World Review     Full-text available via subscription   (Followers: 18)
Communication & Sport     Hybrid Journal   (Followers: 7, SJR: 0.385, CiteScore: 1)
Communication and the Public     Hybrid Journal   (Followers: 1)
Communication Disorders Quarterly     Hybrid Journal   (Followers: 14, SJR: 0.458, CiteScore: 1)
Communication Research     Hybrid Journal   (Followers: 19, SJR: 2.171, CiteScore: 3)
Community College Review     Hybrid Journal   (Followers: 8, SJR: 1.451, CiteScore: 1)
Comparative Political Studies     Hybrid Journal   (Followers: 214, SJR: 3.772, CiteScore: 3)
Compensation & Benefits Review     Hybrid Journal   (Followers: 8)
Competition & Change     Hybrid Journal   (Followers: 11, SJR: 0.843, CiteScore: 2)
Competition and Regulation in Network Industries     Full-text available via subscription   (Followers: 8, SJR: 0.143, CiteScore: 0)
Concurrent Engineering     Hybrid Journal   (Followers: 3, SJR: 0.642, CiteScore: 2)
Conflict Management and Peace Science     Hybrid Journal   (Followers: 33, SJR: 2.441, CiteScore: 1)
Contemporary Drug Problems     Full-text available via subscription   (Followers: 2, SJR: 0.609, CiteScore: 2)
Contemporary Education Dialogue     Hybrid Journal   (Followers: 5, SJR: 0.102, CiteScore: 0)
Contemporary Issues in Early Childhood     Full-text available via subscription   (Followers: 6, SJR: 0.766, CiteScore: 1)
Contemporary Review of the Middle East     Full-text available via subscription   (Followers: 11)
Contemporary Sociology : A J. of Reviews     Full-text available via subscription   (Followers: 34, SJR: 0.195, CiteScore: 0)
Contemporary Voice of Dalit     Full-text available via subscription  
Contexts     Hybrid Journal   (Followers: 5)
Contributions to Indian Sociology     Hybrid Journal   (Followers: 4, SJR: 0.376, CiteScore: 0)
Convergence The Intl. J. of Research into New Media Technologies     Hybrid Journal   (Followers: 50, SJR: 0.521, CiteScore: 1)
Cooperation and Conflict     Hybrid Journal   (Followers: 20, SJR: 0.945, CiteScore: 2)
Cornell Hospitality Quarterly     Hybrid Journal   (Followers: 8, SJR: 1.198, CiteScore: 2)

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Similar Journals
Journal Cover
Cell Transplantation
Journal Prestige (SJR): 1.023
Citation Impact (citeScore): 3
Number of Followers: 4  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0963-6897 - ISSN (Online) 1555-3892
Published by Sage Publications Homepage  [1074 journals]
  • Nanomedicine-based Curcumin Approach Improved ROS Damage in Best
           Dystrophy-specific Induced Pluripotent Stem Cells

    • Authors: Tai-Chi Lin, Yi-Ying Lin, Chih-Chen Hsu, Yi-Ping Yang, Chang-Hao Yang, De-Kuang Hwang, Chien-Ying Wang, Yung-Yang Liu, Wen-Liang Lo, Shih-Hwa Chiou, Chi-Hsien Peng, Shih-Jen Chen, Yuh-Lih Chang
      Abstract: Cell Transplantation, Ahead of Print.
      Best dystrophy (BD), also termed best vitelliform macular dystrophy (BVMD), is a juvenile-onset form of macular degeneration and can cause central visual loss. Unfortunately, there is no clear definite therapy for BD or improving the visual function on this progressive disease. The human induced pluripotent stem cell (iPSC) system has been recently applied as an effective tool for genetic consultation and chemical drug screening. In this study, we developed patient-specific induced pluripotent stem cells (BD-iPSCs) from BD patient-derived dental pulp stromal cells and then differentiated BD-iPSCs into retinal pigment epithelial cells (BD-RPEs). BD-RPEs were used as an expandable platform for in vitro candidate drug screening. Compared with unaffected sibling-derived iPSC-derived RPE cells (Ctrl-RPEs), BD-RPEs exhibited typical RPE-specific markers with a lower expression of the tight junction protein ZO-1 and Bestrophin-1 (BEST1), as well as reduced phagocytic capabilities. Notably, among all candidate drugs, curcumin was the most effective for upregulating both the BEST1 and ZO-1 genes in BD-RPEs. Using the iPSC-based drug-screening platform, we further found that curcumin can significantly improve the mRNA expression levels of Best gene in BD-iPSC-derived RPEs. Importantly, we demonstrated that curcumin-loaded PLGA nanoparticles (Cur-NPs) were efficiently internalized by BD-RPEs. The Cur-NPs-based controlled release formulation further increased the expression of ZO-1 and Bestrophin-1, and promoted the function of phagocytosis and voltage-dependent calcium channels in BD-iPSC-derived RPEs. We further demonstrated that Cur-NPs enhanced the expression of antioxidant enzymes with a decrease in intracellular ROS production and hydrogen peroxide-induced oxidative stress. Collectively, these data supported that Cur-NPs provide a potential cytoprotective effect by regulating the anti-oxidative abilities of degenerated RPEs. In addition, the application of patient-specific iPSCs provides an effective platform for drug screening and personalized medicine in incurable diseases.
      Citation: Cell Transplantation
      PubDate: 2019-07-17T10:59:58Z
      DOI: 10.1177/0963689719860130
       
  • Additional Use of Synovial Mesenchymal Stem Cell Transplantation Following
           Surgical Repair of a Complex Degenerative Tear of the Medial Meniscus of
           the Knee: A Case Report

    • Authors: Ichiro Sekiya, Hideyuki Koga, Koji Otabe, Yusuke Nakagawa, Hisako Katano, Nobutake Ozeki, Mitsuru Mizuno, Masafumi Horie, Yuji Kohno, Kenta Katagiri, Naoto Watanabe, Takeshi Muneta
      Abstract: Cell Transplantation, Ahead of Print.
      Complex degenerative tears of the medial meniscus in the knee are usually treated using meniscectomy. However, this procedure increases the risk of osteoarthritis, while other treatments aimed at meniscal repair remain challenging due to the high possibility of failure. The use of synovial mesenchymal stem cells (MSCs) is an attractive additional approach for meniscal repair, as these cells have high proliferative and chondrogenic potential. In this case report, we surgically repaired a complex degenerative tear of the medial meniscus and then transplanted autologous synovial MSCs. We evaluated clinical outcomes at 2 years and assessed adverse events. We enrolled patients with clinical symptoms that included a feeling of instability in addition to pain caused by their complex degenerative tears of the medial meniscus. Two weeks after surgical repair of the torn meniscus, autologous synovial MSCs were transplanted onto the menisci of five patients. The total Lysholm knee score, the Knee Injury and Osteoarthritis Outcome Scale scores for “pain,” “daily living,” “sports activities,” and the Numerical Rating Scale were significantly increased after 2 years. Three adverse events, an increase in c-reactive protein, joint effusion, and localized warmth of the knee were recorded, although these could have been due to the meniscal repair surgery. This first-in-human study confirmed that the combination of surgical repair and synovial MSC transplantation improved the clinical symptoms in patients with a complex degenerative tear of the medial meniscus. No adverse events occurred that necessitated treatment discontinuation. These findings will serve as pilot data for a future prospective study.
      Citation: Cell Transplantation
      PubDate: 2019-07-17T10:59:58Z
      DOI: 10.1177/0963689719863793
       
  • Neurotrophic Factor Secretion and Neural Differentiation Potential of
           Multilineage-differentiating Stress-enduring (Muse) Cells Derived from
           Mouse Adipose Tissue

    • Authors: Yohshiro Nitobe, Toshihide Nagaoki, Gentaro Kumagai, Ayako Sasaki, Xizhe Liu, Taku Fujita, Tatsuhiro Fukutoku, Kanichiro Wada, Toshihiro Tanaka, Hitoshi Kudo, Toru Asari, Ken-Ichi Furukawa, Yasuyuki Ishibashi
      Abstract: Cell Transplantation, Ahead of Print.
      Multilineage-differentiating stress-enduring (Muse) cells are endogenous pluripotent stem cells that can be isolated based on stage-specific embryonic antigen-3 (SSEA-3), a pluripotent stem cell-surface marker. However, their capacities for survival, neurotrophic factor secretion, and neuronal and glial differentiation are unclear in rodents. Here we analyzed mouse adipose tissue-derived Muse cells in vitro. We collected mesenchymal stem cells (MSCs) from C57BL/6 J mouse adipose tissue and separated SSEA-3+, namely Muse cells, and SSEA-3–, non-Muse cells, to assess self-renewability; pluripotency marker expression (Nanog, Oct3/4, Sox2, and SSEA-3); spontaneous differentiation into endodermal, mesodermal, and ectodermal lineages; and neural differentiation capabilities under cytokine induction. Neurally differentiated Muse and non-Muse cell functions were assessed by calcium imaging. Antioxidant ability was measured to assess survival under oxidative stress. Brain-derived neurotrophic factor (BDNF), vascular endothelial cell growth factor (VEGF), and hepatocyte growth factor (HGF) secretion were analyzed in enzyme-linked immunosorbent assays. SSEA-3+ Muse cells (6.3 ± 1.9% of mouse adipose-MSCs), but not non-Muse cells, exhibited self-renewability, spontaneous differentiation into the three germ layers, and differentiation into cells positive for Tuj-1 (27 ± 0.9%), O4 (17 ± 3.4%), or GFAP (23 ± 1.3%) under cytokine induction. Neurally differentiated Muse cells responded to KCl depolarization with greater increases in cytoplasmic Ca2+ levels than non-Muse cells. Cell survival under oxidative stress was significantly higher in Muse cells (50 ± 2.7%) versus non-Muse cells (22 ± 2.8%). Muse cells secreted significantly more BDNF, VEGF, and HGF (273 ± 12, 1479 ± 7.5, and 6591 ± 1216 pg/mL, respectively) than non-Muse cells (133 ± 4.0, 1165 ± 20, and 2383 ± 540 pg/mL, respectively). Mouse Muse cells were isolated and characterized for the first time. Muse cells showed greater pluripotency-like characteristics, survival, neurotrophic factor secretion, and neuronal and glial-differentiation capacities than non-Muse cells, indicating that they may have better neural-regeneration potential.
      Citation: Cell Transplantation
      PubDate: 2019-07-15T09:37:54Z
      DOI: 10.1177/0963689719863809
       
  • D-mannose-Coating of Maghemite Nanoparticles Improved Labeling of Neural
           Stem Cells and Allowed Their Visualization by ex vivo MRI after
           Transplantation in the Mouse Brain

    • Authors: Igor M. Pongrac, Marina Dobrivojević Radmilović, Lada Brkić Ahmed, Hrvoje Mlinarić, Jan Regul, Siniša Škokić, Michal Babič, Daniel Horák, Mathias Hoehn, Srećko Gajović
      Abstract: Cell Transplantation, Ahead of Print.
      Magnetic resonance imaging (MRI) of superparamagnetic iron oxide-labeled cells can be used as a non-invasive technique to track stem cells after transplantation. The aim of this study was to (1) evaluate labeling efficiency of D-mannose-coated maghemite nanoparticles (D-mannose(γ-Fe2O3)) in neural stem cells (NSC) in comparison to the uncoated nanoparticles, (2) assess nanoparticle utilization as MRI contrast agent to visualize NSC transplanted into the mouse brain, and (3) test nanoparticle biocompatibility. D-mannose(γ-Fe2O3) labeled the NSC better than the uncoated nanoparticles. The labeled cells were visualized by ex vivo MRI and their localization subsequently confirmed on histological sections. Although the progenitor properties and differentiation of the NSC were not affected by labeling, subtle effects on stem cells could be detected depending on dose increase, including changes in cell proliferation, viability, and neurosphere diameter. D-mannose coating of maghemite nanoparticles improved NSC labeling and allowed for NSC tracking by ex vivo MRI in the mouse brain, but further analysis of the eventual side effects might be necessary before translation to the clinic.
      Citation: Cell Transplantation
      PubDate: 2019-07-11T11:20:58Z
      DOI: 10.1177/0963689719834304
       
  • Harnessing Neurogenesis and Neuroplasticity with Stem Cell Treatment for
           Addictive Disorders

    • Authors: Sheng-Tzung Tsai, Hock-Kean Liew, Hao-Ming Li, Shinn-Zong Lin, Shin-Yuan Chen
      Abstract: Cell Transplantation, Ahead of Print.
      Drug and alcohol addiction has become an emerging public health issue and is a great burden to patients, their families, and society. It is characterized by high relapse rates and significant morbidity and mortality, and most available treatments result in only modest improvement. These findings highlight the necessity for new approaches to treat addiction. Scientific reports in the past two decades suggest that addiction involves impaired neural plasticity and decreased hippocampal neurogenesis. Stem cell therapy and its derived neurotrophic factors can potentially target the underlying pathophysiology of addiction. Stem cell applications are showing promise in several preclinical studies and may provide new and noninvasive treatment strategies. Future clinical research is warranted to investigate whether stem cell-based therapy could support the treatment of addiction.
      Citation: Cell Transplantation
      PubDate: 2019-07-04T09:25:49Z
      DOI: 10.1177/0963689719859299
       
  • A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in
           Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma
           Treatment

    • Authors: Konstantinos Pantos, Mara Simopoulou, Agni Pantou, Anna Rapani, Petroula Tsioulou, Nikolaos Nitsos, Stephen Syrkos, Athanasios Pappas, Michael Koutsilieris, Konstantinos Sfakianoudis
      Abstract: Cell Transplantation, Ahead of Print.
      Since the introduction of autologous platelet-rich plasma (PRP) in medical practice, various studies have documented that implementing PRP can enhance healing and the anti-aging process, employing angiogenesis regeneration due to the multiple growth factors and cytokines involved. Numerous reports have shown promising results with the use of PRP in ovarian treatment, regarding ovarian regeneration and reactivation of folliculogenesis. This case series reports on two women with premature ovarian failure (POF) aged 40 and 27 years, respectively, and one menopausal woman aged 46 years. All patients presented with lack of menstrual cycle for over a year. The women reported previous failed in vitro fertilization (IVF) attempts, and, after rejecting the option of oocyte donation, they opted for the approach of autologous ovarian PRP treatment. Following PRP treatment, the three patients were invited to conceive naturally. The primary outcome was the restoration of menstruation following autologous ovarian PRP treatment, as well as an improvement in hormonal profile, a decrease in follicle-stimulating hormone (FSH) levels, and a concurrent increase in anti-Müllerian hormone (AMH) levels. Further to that, our patients achieved pregnancy through natural conception within 2–6 months following PRP treatment, resulting in currently ongoing complication-free clinical pregnancies – a first report in the literature for menopausal and POF patients. Implementation of PRP should be further investigated through randomized controlled trials (RCTs), as it may hold the key to successful treatment for a certain cohort of patients exploring reproductive treatment options following menopause.
      Citation: Cell Transplantation
      PubDate: 2019-07-04T09:25:49Z
      DOI: 10.1177/0963689719859539
       
  • Collagen VII Expression is Required in Both Keratinocytes and Fibroblasts
           for Anchoring Fibril Formation in Bilayer Engineered Skin Substitutes

    • Authors: Dorothy M. Supp, Jennifer M. Hahn, Kelly A. Combs, Kevin L. McFarland, Ann Schwentker, Raymond E. Boissy, Steven T. Boyce, Heather M. Powell, Anne W. Lucky
      Abstract: Cell Transplantation, Ahead of Print.
      The blistering disease Recessive Dystrophic Epidermolysis Bullosa (RDEB) is caused by mutations in the gene encoding collagen VII (COL7), which forms anchoring fibrils that attach the epidermis to the dermis. Cutaneous gene therapy to restore COL7 expression in RDEB patient cells has been proposed, and cultured epithelial autograft containing COL7-modified keratinocytes was previously tested in clinical trials. Because COL7 in normal skin is expressed in both fibroblasts and keratinocytes, cutaneous gene therapy using a bilayer skin substitute may enable faster restoration of anchoring fibrils. Hypothetically, COL7 expression in either dermal fibroblasts or epidermal keratinocytes might be sufficient for functional anchoring fibril formation in a bilayer skin substitute. To test this, engineered skin substitutes (ESS) were prepared using four combinations of normal + RDEB cells: (1) RDEB fibroblasts + RDEB keratinocytes; (2) RDEB fibroblasts + normal keratinocytes; (3) normal fibroblasts + RDEB keratinocytes; and (4) normal fibroblasts + normal keratinocytes. ESS were incubated in vitro for 2 weeks prior to grafting to full-thickness wounds in immunodeficient mice. Biopsies were analyzed in vitro and at 1, 2, or 3 weeks after grafting. COL7 was undetectable in ESS prepared using all RDEB cells (group 1), and macroscopic blistering was observed by 2 weeks after grafting in ESS containing RDEB cells. COL7 was expressed, in vitro and in vivo, in ESS prepared using combinations of normal + RDEB cells (groups 2 and 3) or all normal cells (group 4). However, transmission electron microscopy revealed structurally normal anchoring fibrils, in vitro and by week 2 in vivo, only in ESS prepared using all normal cells (group 4). The results suggest that although COL7 protein is produced in engineered skin when cells in only one layer express the COL7 gene, formation of structurally normal anchoring fibrils appears to require expression of COL7 in both dermal fibroblasts and epidermal keratinocytes.
      Citation: Cell Transplantation
      PubDate: 2019-07-04T09:25:48Z
      DOI: 10.1177/0963689719857657
       
  • miR-145 Contributes to the Progression of Cervical Carcinoma by Directly
           Regulating FSCN1

    • Authors: Li Ma, Ling-Ling Li
      Abstract: Cell Transplantation, Ahead of Print.
      The purpose of our study was to investigate the underlying mechanism and functional role of microRNA-145 (miR-145) in cervical cancer. In this study, quantitative real-time PCR (qRT-PCR) was used to detect miR-145 and FSCN1 expression levels in tissues and HeLa cells. Western blotting was performed to determine the protein level of FSCN1. The luciferase assay was used to verify the direct target of miR-145. The CCK-8 assay and 2D colony formation assays were performed to determine the effects of miR-145 mimics or FSCN1 silencing on cell proliferation. miR-145 expression levels were significantly down-regulated, while FSCN1 expression levels were significantly up-regulated in the cervical carcinoma tissues compared with their matched non-cancerous tissues. In addition, FSCN1 expression levels were negatively correlated to miR-145 in tissues. Next, FSCN1 was verified as the direct target of miR-145 in HeLa cells. Moreover, overexpression of miR-145 dramatically inhibited the proliferation of HeLa cells. The silencing of FSCN1 exhibited the similar patterns on cell proliferation as miR-145 overexpression. The miR-145/ FSCN1 axis contributes to the progression of cervical cancer by inhibition of cervical cancer cell proliferation.
      Citation: Cell Transplantation
      PubDate: 2019-07-04T09:25:48Z
      DOI: 10.1177/0963689719861063
       
  • Reconstruction of the Damaged Dorsal Root Entry Zone by Transplantation of
           Olfactory Ensheathing Cells

    • Authors: Andrew Collins, Ahmed Ibrahim, Daqing Li, Modinat Liadi, Ying Li
      Abstract: Cell Transplantation, Ahead of Print.
      The dorsal root entry zone is often used in research to examine the disconnection between the central and peripheral parts of the nervous system which occurs following injury. Our laboratory and others have used transplantation of olfactory ensheathing cells (OECs) to repair experimental spinal cord injuries. We have previously used a four dorsal root (C6–T1) transection model to show that transplantation of OECs can reinstate rat forelimb proprioception in a climbing task. Until now, however, we have not looked in detail at the anatomical interaction between OECs and the peripheral/central nervous system regions which form the transitional zone. In this study, we compared short- and long-term OEC survival and their interaction with the surrounding dorsal root tissue. We reveal how transplanted OECs orient toward the spinal cord and allow newly formed axons to travel across into the dorsal horn of the spinal cord. Reconstruction of the dorsal root entry zone was supported by OEC ensheathment of axons at the injured site and also at around 3 mm further away at the dorsal root ganglion. Quantitative analysis revealed no observable difference in dorsal column axonal loss between transplanted and control groups of rats.
      Citation: Cell Transplantation
      PubDate: 2019-07-04T09:25:47Z
      DOI: 10.1177/0963689719855938
       
  • Neural Stem Cell Transplantation Improves Locomotor Function in Spinal
           Cord Transection Rats Associated with Nerve Regeneration and IGF-1 R
           Expression

    • Authors: Xiao-Ming Zhao, Xiu-Ying He, Jia Liu, Yang Xu, Fei-Fei Xu, Ya-Xin Tan, Zi-Bin Zhang, Ting-Hua Wang
      Abstract: Cell Transplantation, Ahead of Print.
      Transplantation of neural stem cells (NSCs) is a potential strategy for the treatment of spinal cord transection (SCT). Here we investigated whether transplanted NSCs would improve motor function of rats with SCT and explored the underlying mechanism. First, the rats were divided into sham, SCT, and NSC groups. Rats in the SCT and NSC groups were all subjected to SCT in T10, and were administered with media and NSC transplantation into the lesion site, respectively. Immunohistochemistry was used to label Nestin-, TUNEL-, and NeuN-positive cells and reveal the expression and location of type I insulin-like growth factor receptor (IGF-1 R). Locomotor function of hind limbs was assessed by Basso, Beattie, Bresnahan (BBB) score and inclined plane test. The conduction velocity and amplitude of spinal nerve fibers were measured by electrophysiology and the anatomical changes were measured using magnetic resonance imaging. Moreover, expression of IGF-1 R was determined by real-time polymerase chain reaction and western blotting. The results showed that NSCs could survive and differentiate into neurons in vitro and in vivo. SCT-induced deficits were reduced by NSC transplantation, including increase in NeuN-positive cells and decrease in apoptotic cells. Moreover, neurophysiological profiles indicated that the latent period was decreased and the peak-to-peak amplitude of spinal nerve fibers conduction was increased in transplanted rats, while morphological measures indicated that fractional anisotropy and the number of nerve fibers in the site of spinal cord injury were increased after NSC transplantation. In addition, mRNA and protein level of IGF-1 R were increased in the rostral segment in the NSC group, especially in neurons. Therefore, we concluded that NSC transplantation promotes motor function improvement of SCT, which might be associated with activated IGF-1 R, especially in the rostral site. All of the above suggests that this approach has potential for clinical treatment of spinal cord injury.
      Citation: Cell Transplantation
      PubDate: 2019-07-04T09:25:46Z
      DOI: 10.1177/0963689719860128
       
  • B Lymphocytes are the Target of Mesenchymal Stem Cells Immunoregulatory
           Effect in a Murine Graft-versus-Host Disease Model

    • Authors: Di Lu, Tian Ma, XiangBin Zhou, YanMing Jiang, Yan Han, Hong Li
      Abstract: Cell Transplantation, Ahead of Print.
      There is growing clinical interest in the utilization of mesenchymal stem cells (MSCs) in the management of acute graft-versus-host disease (aGvHD), yet the effect of major histocompatibility complexes (MHCs) on B lymphocytes in this process has been less well documented. Working in an MHC fully mismatched murine aGvHD model, we found that MSC co-transfer significantly prolonged the survival time of the recipients. More interestingly, analysis on immunophenotypic profiles of posttransplant splenocytes showed that surface expression of CD69 (an early activation marker) and CD86 (a costimulatory molecule) was suppressed predominantly on donor derived B lymphocytes by MSC infusion. Additionally, mRNA level of interleukin-4, a potent B lymphocyte stimulator, was strikingly reduced from MSC-treated mice, while interleukin-10, the regulatory B lymphocytes inductor, was increased; these may underlie the lesser activation of B lymphocytes. In consistence, depletion of B lymphocytes in the transfusion inoculum further prolonged the survival time of aGvHD mice regardless of MSC administration. Therefore, B lymphocytes played an important role in the development of aGvHD, and they are targets in MSC-regulated immune response cascade in vivo. This study may provide a mechanistic clue for the treatment of human clinical aGvHD.
      Citation: Cell Transplantation
      PubDate: 2019-07-01T12:05:12Z
      DOI: 10.1177/0963689719860127
       
  • Metabolic Syndrome Induces Release of Smaller Extracellular Vesicles from
           Porcine Mesenchymal Stem Cells

    • Authors: Sabena M. Conley, John E. Shook, Xiang-Yang Zhu, Alfonso Eirin, Kyra L. Jordan, John R. Woollard, Busra Isik, LaTonya J. Hickson, Amrutesh S. Puranik, Lilach O. Lerman
      Abstract: Cell Transplantation, Ahead of Print.
      Mesenchymal stromal/stem cells (MSC) belong to the endogenous cellular reparative system, and can be used exogenously in cell-based therapy. MSC release extracellular vesicles (EV), including exosomes and microvesicles, which mediate some of their therapeutic activity through intercellular communication. We have previously demonstrated that metabolic syndrome (MetS) modifies the cargo packed within swine EV, but whether it influences their phenotypical characteristics remains unclear. This study tested the hypothesis that MetS shifts the size distribution of MSC-derived EV. Adipose tissue-derived MSC-EV subpopulations from Lean (n = 6) and MetS (n = 6) pigs were characterized for number and size using nanoparticle-tracking analysis, flow cytometry, and transmission electron microscopy. Expression of exosomal genes was determined using next-generation RNA-sequencing (RNA-seq). The number of EV released from Lean and MetS pig MSC was similar, yet MetS-MSC yielded a higher proportion of small-size EV (202.4 ± 17.7 nm vs. 280.3 ± 15.1 nm), consistent with exosomes. RNA-seq showed that their EVs were enriched with exosomal markers. Lysosomal activity remained unaltered in MetS-MSC. Therefore, MetS alters the size distribution of MSC-derived EV in favor of exosome release. These observations may reflect MSC injury and membrane recycling in MetS or increased expulsion of waste products, and may have important implications for development of adequate cell-based treatments.
      Citation: Cell Transplantation
      PubDate: 2019-06-28T12:22:53Z
      DOI: 10.1177/0963689719860840
       
  • Stem Cell-Related Studies and Stem Cell-Based Therapies in Liver Diseases

    • Authors: Wei Zhou, Erek D. Nelson, Anan A. Abu Rmilah, Bruce P. Amiot, Scott L. Nyberg
      Abstract: Cell Transplantation, Ahead of Print.
      Owing to the increasing worldwide burden of liver diseases, the crucial need for safe and effective interventions for treating end-stage liver failure has been a very productive line of inquiry in the discipline of hepatology for many years. Liver transplantation is recognized as the most effective treatment for end-stage liver disease; however, the shortage of donor organs, high medical costs, and lifelong use of immunosuppressive agents represent major drawbacks and demand exploration for alternative treatments. Stem cell-based therapies have been widely studied in the field of liver diseases and are considered to be among the most promising therapies. Herein, we review recent advances in the application of stem cell-related therapies in liver disease with the aim of providing readers with relevant knowledge in this field and inspiration to spur further inquiry.
      Citation: Cell Transplantation
      PubDate: 2019-06-26T09:31:42Z
      DOI: 10.1177/0963689719859262
       
  • Cells Involved in Urethral Tissue Engineering: Systematic Review

    • Authors: Martina Culenova, Stanislav Ziaran, Lubos Danisovic
      Abstract: Cell Transplantation, Ahead of Print.
      The urethra is part of the lower urinary tract and its main role is urine voiding. Its complex histological structure makes urethral tissue prone to various injuries with complicated healing processes that often lead to scar formation. Urethral stricture disease can affect both men and women. The occurrence of this pathology is more common in men and thus are previous research has been mainly oriented on male urethra reconstruction. However, commonly used surgical techniques show unsatisfactory results because of complications. The new and progressively developing field of tissue engineering offers promising solutions, which could be applied in the urethral regeneration of both men´s and women´s urethras. The presented systematic review article offers an overview of the cells that have been used in urethral tissue engineering so far. Urine-derived stem cells show a great perspective in respect to urethral tissue engineering. They can be easily harvested and are a promising autologous cell source for the needs of tissue engineering techniques. The presented review also shows the importance of mechanical stimuli application on maturating tissue. Sufficient vascularization and elimination of stricture formation present the biggest challenges not only in customary surgical management but also in tissue-engineering approaches.
      Citation: Cell Transplantation
      PubDate: 2019-06-25T10:47:11Z
      DOI: 10.1177/0963689719854363
       
  • CD200Fc Improves Neurological Function by Protecting the Blood–brain
           Barrier after Intracerebral Hemorrhage

    • Authors: Chen-sheng Le, Xiao-di Hao, Jia-wen Li, Jia-wei Zhong, Hao-ran Lin, Yi-ting Zhou, Zachary D. Travis, Lu-sha Tong, Feng Gao
      Abstract: Cell Transplantation, Ahead of Print.
      CD200 is widely distributed in the central nervous system and plays an essential role in the immune response in neurological diseases. However, little is currently known about the effects of CD200 signaling on the blood–brain barrier (BBB) function after intracerebral hemorrhage (ICH). In this study, the role of CD200 during ICH in an autologous blood induced mouse ICH model was investigated. Following ICH, critical protein expression, BBB permeability, and neurological function were measured with or without CD200Fc administration. Our results showed that both the expression of CD200 and CD200R1 decreased after ICH and administration of CD200Fc attenuated BBB leakage and improved neurological functions. In conclusion, our work demonstrated that CD200Fc might be a potential treatment option for ICH by protecting the BBB and improving functional outcomes.
      Citation: Cell Transplantation
      PubDate: 2019-06-18T06:19:03Z
      DOI: 10.1177/0963689719857655
       
  • Initiating TrkB/Akt Signaling Cascade Preserves Blood–Brain Barrier
           after Subarachnoid Hemorrhage in Rats

    • Authors: Xiangqian Qi, Juan Liu, Jiejin Wu, Yunke Bi, Cong Han, Guiyun Zhang, Meiqing Lou, Jianfei Lu, Junjia Tang
      Abstract: Cell Transplantation, Ahead of Print.
      The integrity of the blood–brain barrier (BBB) plays a vital role in affecting the prognosis of subarachnoid hemorrhage (SAH). This study aimed to investigate activation of the Tropomyosin-related kinase receptor B (TrkB) and its downstream signaling pathway on preserving BBB breakdown after experimental SAH. An endovascular perforation SAH model was applied. N-[2-(5-hydroxy-1H-indol-3-yl) ethyl]-2- oxopiperidine-3-carboxamide (HIOC), the derivative of N-acetyl serotonin (NAS), was intracerebroventricularly administered 3 h after SAH induction. The neurologic scores and brain water content were evaluated in an outcome study. Western blot and immunofluorescence staining were used to investigate the mechanism. The results indicated that HIOC activated the TrkB/Akt pathway, increased the tight junction expression, improved neurologic deficits, and ameliorated brain edema after SAH. Thus, we conclude that initiating the TrkB/Akt signaling cascade preserves BBB breakdown after experimental SAH in rats.
      Citation: Cell Transplantation
      PubDate: 2019-06-18T06:19:02Z
      DOI: 10.1177/0963689719857649
       
  • The Impact of Limbal Mesenchymal Stromal Cells on Healing of Acute Ocular
           Surface Wounds is Improved by Pre-cultivation and Implantation in the
           Presence of Limbal Epithelial Cells

    • Authors: Elham Nili, Fiona J. Li, Rebecca A. Dawson, Cora Lau, Blair McEwan, Nigel L. Barnett, Steven Weier, Jennifer Walshe, Neil A. Richardson, Damien G. Harkin
      Abstract: Cell Transplantation, Ahead of Print.
      While limbal epithelial cells are used for treating ocular surface wounds, the therapeutic potential of mesenchymal cells cultivated from the limbal stroma (LMSC) is less clear. We have therefore examined the effects of LMSC when applied to acute ocular surface wounds. LMSC derived from male rabbits (RLMSC) were applied to the ocular surface of female rabbits immediately following removal of the corneal and limbal epithelium. Human amniotic membrane (HAM) was used as the vehicle for implanting the RLMSC. The effects of RLMSC were examined when applied alone (n = 3) and in conjunction with a stratified culture of human limbal epithelial cells (HLE) grown on the opposing surface of the HAM (n = 3). Outcomes were monitored over 3 months in comparison with animals receiving no treatment (n = 3) or treatment with HLE alone on HAM (n = 3). Animals treated with RLMSC (n = 6) displayed faster re-epithelialization (∼90% versus 70% healing after 12 weeks), with best results being observed when RLMSC were pre-cultivated and implanted in the presence of HLE (p < 0.01; 90% healing by 7 weeks). While all animals displayed conjunctival cells on the corneal surface (by presence of goblet cells and/or keratin 13 expression) and corneal neovascularization, evidence of corneal epithelial regeneration was observed in animals that received RLMSC in the presence of HLE (by staining for keratin 3 and the absence of goblet cells). Conversely, corneal neovascularization was significantly greater when RLMSC were applied in the absence of HLE (
      Citation: Cell Transplantation
      PubDate: 2019-06-18T06:19:02Z
      DOI: 10.1177/0963689719858577
       
  • MicroRNA-101a Regulates Autophagy Phenomenon via the MAPK Pathway to
           Modulate Alzheimer’s-Associated Pathogenesis

    • Authors: Qian Li, Yu Wang, Wenjie Peng, Yanjie Jia, Jinhua Tang, Wanwei Li, John H. Zhang, Jun Yang
      Abstract: Cell Transplantation, Ahead of Print.
      Alzheimer’s disease (AD) is a type of neurodegenerative disorder and the most common form of dementia. MicroRNA (miRNA) has been shown to play a role in various diseases, including AD. It also has been reported to regulate autophagy. We extracted miRNA from blood samples and constructed an miRNA-101a lentivirus vector. In this study we found the level of miRNA-101a was significantly reduced in the plasma of patients with AD and APPswe/PS1ΔE9 transgenic mice. The relative expression of miRNA-101a exhibited a relatively high diagnostic performance (area under receiver operating characteristic curve: 0.8725) in the prediction of AD with a sensitivity of 0.913 and a specificity of 0.733 at the threshold of 0.6463. Under electron microscopy, autophagic vacuoles in AD-related cells numbered more than the cells up-regulating miRNA-101a in the in vitro experiments. Dual-luciferase reporter assay and western blot results proved that the MAPK1 pathway plays a role in the formation of autophagic vacuoles in AD. This study found that the autophagy phenomenon regulated by miRNA-101a via the MAPK pathway might be a new mechanism in AD. This could provide new insights into AD formation and treatment.
      Citation: Cell Transplantation
      PubDate: 2019-06-17T11:17:20Z
      DOI: 10.1177/0963689719857085
       
  • Detection of Crossed Cerebellar Diaschisis by Intravoxel Incoherent Motion
           MR Imaging in Subacute Ischemic Stroke

    • Authors: Juan Wang, Shiteng Suo, Jinyan Zu, Wanqiu Zhu, Lijun Pan, Shaoli Song, Yang Li, Lei Li, Zengai Chen, Jianrong Xu
      Abstract: Cell Transplantation, Ahead of Print.
      Intravoxel incoherent motion has received extensive attention in brain studies for its potential as a non-invasive magnetic resonance perfusion method. However, studies on intravoxel incoherent motion imaging and crossed cerebellar diaschisis detection are relatively scarce. The aim of our study was to evaluate the feasibility of using intravoxel incoherent motion imaging in crossed cerebellar diaschisis diagnosis in subacute ischemic stroke patients by comparing results from intravoxel incoherent motion imaging, single-photon emission computed tomography, and arterial spin-labeling perfusion methods. In total, 39 patients with subacute ischemic stroke who underwent intravoxel incoherent motion, arterial spin-labeling, and single-photon emission computed tomography scanning were enrolled. Intravoxel incoherent motion-derived perfusion-related parameters including fast diffusion coefficient, vascular volume fraction, arterial spin-labeling-derived cerebral blood flow as well as single-photon emission computed tomography-derived cerebral blood flow of bilateral cerebellum were measured. A crossed cerebellar diaschisis-positive result was considered present with an asymmetry index ≥10% of single-photon emission computed tomography. In the crossed cerebellar diaschisis-positive group, fast diffusion coefficient, arterial spin-labeling-derived cerebral blood flow, and computed tomography-derived cerebral blood flow of the contralateral cerebellum decreased compared with those of the ipsilesional cerebellum; whereas vascular volume fraction significantly increased. The National Institutes of Health Stroke Scale score and infarct volume in the crossed cerebellar diaschisis-positive group were significantly higher than those in the crossed cerebellar diaschisis-negative group. A positive correlation was detected between the fast diffusion coefficient-based asymmetry index and the single-photon emission computed tomography-based asymmetry index, fast diffusion coefficient-based asymmetry, and arterial spin-labeling based asymmetry index; whereas the vascular volume fraction-based asymmetry index value had a negative correlation with the single-photon emission computed tomography-based asymmetry index and arterial spin-labeling based asymmetry index. Furthermore, the area under the receiver operating characteristic curve value of the arterial spin-labeling-based asymmetry index was 0.923. The fast diffusion coefficient derived from the intravoxel incoherent motion could be valuable for the assessment of crossed cerebellar diaschisis in supratentorial stroke patients.
      Citation: Cell Transplantation
      PubDate: 2019-06-14T10:54:20Z
      DOI: 10.1177/0963689719856290
       
  • The neuroprotection of hypoxic adipose tissue-derived mesenchymal stem
           cells in experimental traumatic brain injury

    • Authors: Hui Ma, Ping Kuen Lam, Cindy See Wai Tong, Kin Ki Yan Lo, George Kwok Chu Wong, Wai Sang Poon
      Abstract: Cell Transplantation, Ahead of Print.
      Traumatic brain injury is one of the leading causes of mortality and morbidity worldwide. At present there is no effective treatment. Previous studies have demonstrated that topical application of adipose tissue-derived mesenchymal stem cells can improve functional recovery in experimental traumatic brain injury. In this study, we evaluated whether hypoxic preconditioned mesenchymal stem cells could enhance the recovery from traumatic brain injury. Traumatic brain injury was induced with an electromagnetically controlled cortical impact device. Two million mesenchymal stem cells derived from the adipose tissue of transgenic green fluorescent protein Sprague-Dawley rats were cultured under either hypoxic (2.5% O2 for 18 hours) (N = 30) or normoxic (18% O2) (N = 30) conditions, then topically applied to the exposed cerebral cortex within 1 hour after traumatic brain injury. A thin layer of fibrin was used to fix the cells in position. No treatment was given to the animals with traumatic brain injury (N = 30). Animals that underwent craniectomy without traumatic brain injury were treated as the sham group (N = 15). Neurological functions were evaluated with water maze, Roto-rod and gait analysis. Animals were sacrificed at days 3, 7, and 14 for microscopic examinations and real-time polymerase chain reaction analysis. The rats treated with hypoxic mesenchymal stem cells showed the greatest improvement in neurological function recovery. More green fluorescent protein-positive cells were found in the injured brain parenchyma treated with hypoxic mesenchymal stem cells that co-expressed glial fibrillary acidic protein, Nestin, and NeuN. Moreover, there was early astrocytosis triggered by the infiltration of more glial fibrillary acidic protein-positive cells and microgliosis was suppressed with fewer ionized calcium binding adapter molecule 1-positive cells in the penumbra region of hypoxic mesenchymal stem cells group at day 3. Compared with normoxic mesenchymal stem cells and traumatic brain injury only groups, there was significantly (p < 0.05) less neuronal death in both the hippocampus and penumbral regions in sections treated with hypoxic mesenchymal stem cells as determined by Cresyl violet and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling staining respectively. The expression of pro-inflammatory genes (interleukin 6, interleukin 1a, interleukin 1b, tumor necrosis factor α) was upregulated and apoptotic gene (Caspase-3) expression was suppressed at day 3. Anti-inflammatory (interleukin 10) and anti-apoptotic (BCL2 associated agonist of cell death) gene expression was upregulated at days 7 and 14. Our study showed that a hypoxic precondition enhanced the beneficial effects of mesenchymal stem cells on neurological recovery after traumatic brain injury.
      Citation: Cell Transplantation
      PubDate: 2019-06-12T07:03:30Z
      DOI: 10.1177/0963689719855624
       
  • The Efficacy of a Scaffold-free Bio 3D Conduit Developed from Autologous
           Dermal Fibroblasts on Peripheral Nerve Regeneration in a Canine Ulnar
           Nerve Injury Model: A Preclinical Proof-of-Concept Study

    • Authors: Sadaki Mitsuzawa, Ryosuke Ikeguchi, Tomoki Aoyama, Hisataka Takeuchi, Hirofumi Yurie, Hiroki Oda, Souichi Ohta, Mika Ushimaru, Tatsuya Ito, Mai Tanaka, Yoshihiro Kunitomi, Manami Tsuji, Shizuka Akieda, Koichi Nakayama, Shuichi Matsuda
      Abstract: Cell Transplantation, Ahead of Print.
      Autologous nerve grafting is widely accepted as the gold standard treatment for segmental nerve defects. To overcome the inevitable disadvantages of the original method, alternative methods such as the tubulization technique have been developed. Several studies have investigated the characteristics of an ideal nerve conduit in terms of supportive cells, scaffolds, growth factors, and vascularity. Previously, we confirmed that biological scaffold-free conduits fabricated from human dermal fibroblasts promote nerve regeneration in a rat sciatic nerve injury model. The purpose of this study is to evaluate the feasibility of biological scaffold-free conduits composed of autologous dermal fibroblasts using a large-animal model. Six male beagle dogs were used in this study. Eight weeks before surgery, dermal fibroblasts were harvested from their groin skin and grown in culture. Bio 3D conduits were assembled from proliferating dermal fibroblasts using a Bio 3D printer. The ulnar nerve in each dog’s forelimb was exposed under general anesthesia and sharply cut to create a 5 mm interstump gap, which was bridged by the prepared 8 mm Bio 3D conduit. Ten weeks after surgery, nerve regeneration was investigated. Electrophysiological studies detected compound muscle action potentials (CMAPs) of the hypothenar muscles and motor nerve conduction velocity (MNCV) in all animals. Macroscopic observation showed regenerated ulnar nerves. Low-level hypothenar muscle atrophy was confirmed. Immunohistochemical, histological, and morphometric studies confirmed the existence of many myelinated axons through the Bio 3D conduit. No severe adverse event was reported. Hypothenar muscles were re-innervated by regenerated nerve fibers through the Bio 3D conduit. The scaffold-free Bio 3D conduit fabricated from autologous dermal fibroblasts is effective for nerve regeneration in a canine ulnar nerve injury model. This technology was feasible as a treatment for peripheral nerve injury and segmental nerve defects in a preclinical setting.
      Citation: Cell Transplantation
      PubDate: 2019-06-12T07:03:27Z
      DOI: 10.1177/0963689719855346
       
  • A Hallmark Clinical Study of Cord Blood Therapy in Adults with Ischemic
           Stroke

    • Authors: Paul R. Sanberg, Jared Ehrhart
      Abstract: Cell Transplantation, Ahead of Print.
      The therapeutic application of human umbilical cord blood cells has been an area of great interest for at least the last 25 years. Currently, cord blood cells are approved for reconstitution of the bone marrow following myeloablation in both young and old patients with myeloid malignancies and other blood cancers. Translational studies investigating alternative uses of cord blood have also shown that these cells not only stimulate neurogenesis in the aged brain but are also potentially therapeutic in the treatment of adult neurodegenerative disorders including amyotrophic lateral sclerosis, Alzheimer’s disease, ischemic stroke, traumatic brain injury, and Parkinson’s disease. Recent advances in the clinical application of cord blood cells by Dr. Joanne Kurtzberg and colleagues have found that non-HLA matched allogeneic banked cord blood units in immunocompetent patients with ischemic stroke are safe and well tolerated. Although the exact mechanism(s) of action that provide the beneficial effects observed from a cord blood cell-based therapy are currently unknown, several studies using models of neurodegenerative disease have shown these cells are immune-modulatory and anti-inflammatory. Thus, any future clinical studies investigating the efficacy of this cord blood cell therapeutic would strongly benefit from the inclusion of methodologies to determine changes in both markers of inflammation and the response of immune tissues, such as the spleen, in subjects receiving cell infusion.
      Citation: Cell Transplantation
      PubDate: 2019-06-11T12:20:41Z
      DOI: 10.1177/0963689719854354
       
  • (-)-Phenserine Ameliorates Contusion Volume, Neuroinflammation, and
           Behavioral Impairments Induced by Traumatic Brain Injury in Mice

    • Authors: Shih-Chang Hsueh, Daniela Lecca, Nigel H. Greig, Jia-Yi Wang, Warren Selman, Barry J. Hoffer, Jonathan P. Miller, Yung-Hsiao Chiang
      Abstract: Cell Transplantation, Ahead of Print.
      Traumatic brain injury (TBI), a major cause of mortality and morbidity, affects 10 million people worldwide, with limited treatment options. We have previously shown that (-)-phenserine (Phen), an acetylcholinesterase inhibitor originally designed and tested in clinical phase III trials for Alzheimer’s disease, can reduce neurodegeneration after TBI and reduce cognitive impairments induced by mild TBI. In this study, we used a mouse model of moderate to severe TBI by controlled cortical impact to assess the effects of Phen on post-trauma histochemical and behavioral changes. Animals were treated with Phen (2.5 mg/kg, IP, BID) for 5 days started on the day of injury and the effects were evaluated by behavioral and histological examinations at 1 and 2 weeks after injury. Phen significantly attenuated TBI-induced contusion volume, enlargement of the lateral ventricle, and behavioral impairments in motor asymmetry, sensorimotor functions, motor coordination, and balance functions. The morphology of microglia was shifted to an active from a resting form after TBI, and Phen dramatically reduced the ratio of activated to resting microglia, suggesting that Phen also mitigates neuroinflammation after TBI. While Phen has potent anti-acetylcholinesterase activity, its (+) isomer Posiphen shares many neuroprotective properties but is almost completely devoid of anti-acetylcholinesterase activity. We evaluated Posiphen at a similar dose to Phen and found similar mitigation in lateral ventricular size increase, motor asymmetry, motor coordination, and balance function, suggesting the improvement of these histological and behavioral tests by Phen treatment occur via pathways other than anti-acetylcholinesterase inhibition. However, the reduction of lesion size and improvement of sensorimotor function by Posiphen were much smaller than with equivalent doses of Phen. Taken together, these results show that post-injury treatment with Phen over 5 days significantly ameliorates severity of TBI. These data suggest a potential development of this compound for clinical use in TBI therapy.
      Citation: Cell Transplantation
      PubDate: 2019-06-10T08:52:15Z
      DOI: 10.1177/0963689719854693
       
  • Pancreatic Stellate Cells Facilitate Perineural Invasion of Pancreatic
           Cancer via HGF/c-Met Pathway

    • Authors: Ligang Nan, Tao Qin, Ying Xiao, Weikun Qian, Jie Li, Zheng Wang, Jiguang Ma, Qingyong Ma, Zheng Wu
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-06-04T11:00:41Z
      DOI: 10.1177/0963689719851772
       
  • Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce
           Behavioral Deficits in Experimental Ischemic Stroke

    • Authors: Tatiana Taís Sibov, Lorena Favaro Pavon, Francisco Romero Cabral, Ivone Farias Cunha, Daniela Mara de Oliveira, Jean Gabriel de Souza, Luciana Cavalheiro Marti, Edgar Ferreira da Cruz, Jackeline Moraes Malheiros, Fernando F. Paiva, Alberto Tannús, Sérgio Mascarenhas de Oliveira, Marcos Devanir Silva da Costa, Patrícia A. Dastoli, Jardel N. Mendonça, Silvia Regina Caminada de Toledo, Suzana M. Fleury Malheiros, Manoel Antonio de Paiva Neto, Nelma Bastos Bezerra Rego, Antônio Fernandes Moron, Sérgio Cavalheiro
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-06-04T11:00:40Z
      DOI: 10.1177/0963689719854342
       
  • Analysis of Synapses in Cerebral Organoids

    • Authors: Abraam M. Yakoub, Mark Sadek
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-06-04T11:00:39Z
      DOI: 10.1177/0963689718822811
       
  • Adipose-Derived Neural Stem Cells Combined with Acellular Dermal Matrix as
           a Neural Conduit Enhances Peripheral Nerve Repair

    • Authors: Wei-Ze Syu, Dueng-Yuan Hueng, Wei-Liang Chen, James Yi-Hsin Chan, Shyi-Gen Chen, Shih-Ming Huang
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-05-31T11:30:00Z
      DOI: 10.1177/0963689719853512
       
  • TGF-β in Mice Ameliorates Experimental Autoimmune Encephalomyelitis in
           Regulating NK Cell Activity

    • Authors: J. Xu, Y. Wang, H. Jiang, M. Sun, J. Gao, A. Xie
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-05-29T07:28:58Z
      DOI: 10.1177/0963689719852354
       
  • Retrospective Case Series of Traumatic Brain Injury and Post-Traumatic
           Stress Disorder Treated with Hyperbaric Oxygen Therapy

    • Authors: R. Douglas Shytle, David J. Eve, Soel-Hee Kim, Allan Spiegel, Paul R. Sanberg, Cesar V. Borlongan
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-05-28T10:11:32Z
      DOI: 10.1177/0963689719853232
       
  • Protective Effect of Hyperbaric Oxygen Therapy on Cognitive Function in
           Patients with Vascular Dementia

    • Authors: Yuzhen Xu, Qian Wang, Zhongsen Qu, Jiajun Yang, Xinping Zhang, Yuwu Zhao
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-05-28T10:11:32Z
      DOI: 10.1177/0963689719853540
       
  • Anti-Platelet Therapy in Mild Cerebral Infarction Patients on the Basis of
           CYP2C19 Metabolizer Status

    • Authors: Hu Lan, Tang Ying, Sheng Xi-Hua, Li Yi
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-05-28T10:11:31Z
      DOI: 10.1177/0963689719851769
       
  • Stereotactic Catheter Drainage Versus Conventional Craniotomy for Severe
           Spontaneous Intracerebral Hemorrhage in the Basal Ganglia

    • Authors: Jia Shi, Zhonghai Cai, Wei Han, Bo Dong, Yumin Mao, Jiachao Cao, Suinuan Wang, Wei Guan
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-05-27T07:05:21Z
      DOI: 10.1177/0963689719852302
       
  • Immunological Characteristics and Properties of Glial Restricted
           Progenitors of Mice, Canine Primary Culture Suspensions, and Human QSV40
           Immortalized Cell Lines for Prospective Therapies of Neurodegenerative
           Disorders

    • Authors: Aleksandra Klimczak, Urszula Kozłowska, Joanna Sanford, Piotr Walczak, Izabela Małysz-Cymborska, Maciej Kurpisz
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-05-24T11:44:58Z
      DOI: 10.1177/0963689719848355
       
  • Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell
           Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases

    • Authors: Jingsong Wang, Karina T Wright, Jade Perry, Bernhard Tins, Timothy Hopkins, Charlotte Hulme, Helen S McCarthy, Ashley Brown, James B Richardson
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-05-08T09:28:21Z
      DOI: 10.1177/0963689719845328
       
  • Immunomodulation with Human Umbilical Cord Blood Stem Cells Ameliorates
           Ischemic Brain Injury – A Brain Transcriptome Profiling Analysis

    • Authors: Maple L. Shiao, Ce Yuan, Andrew T. Crane, Joseph P. Voth, Mario Juliano, Laura L. Hocum Stone, Zhenghong Nan, Ying Zhang, Nicole Kuzmin-Nichols, Paul R. Sanberg, Andrew W. Grande, Walter C. Low
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-05-08T09:13:41Z
      DOI: 10.1177/0963689719836763
       
  • Clinical Manifestations and Mechanisms of Autoimmune Disease-Related
           Multiple Cerebral Infarcts

    • Authors: Li-Li Sun, Wen-Xiong Tang, Min Tian, Lu Zhang, Zun-Jing Liu
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-05-07T11:11:29Z
      DOI: 10.1177/0963689719846838
       
  • Transendocardial CD34+ Cell Therapy does not Increase the Risk of
           Ventricular Arrhythmias in Patients with Chronic Heart Failure

    • Authors: Gregor Poglajen, Gregor Zemljič, Andraž Cerar, Sabina Frljak, Martina Jaklič, Vesna Androcec, Bojan Vrtovec
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-05-03T06:03:19Z
      DOI: 10.1177/0963689719840351
       
  • Upregulation of MicroRNA-128 in the Peripheral Blood of Acute Ischemic
           Stroke Patients is Correlated with Stroke Severity Partially through
           Inhibition of Neuronal Cell Cycle Reentry

    • Authors: Ping Liu, Ziping Han, Qingfeng Ma, Tao Liu, Rongliang Wang, Zhen Tao, Guangwen Li, Fangfang Li, Sijia Zhang, Lingzhi Li, Xuming Ji, Haiping Zhao, Yumin Luo
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-30T09:50:06Z
      DOI: 10.1177/0963689719846848
       
  • Cost and Scalability Analysis of Porcine Islet Isolation for Islet
           Transplantation: Comparison of Juvenile, Neonatal and Adult Pigs

    • Authors: Rachel Vanderschelden, Mayilone Sathialingam, Michael Alexander, Jonathan R. T. Lakey
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-30T09:50:04Z
      DOI: 10.1177/0963689719847460
       
  • Telocytes as a Novel Structural Component in the Muscle Layers of the Goat
           Rumen

    • Authors: Yu Liang, Siyi Wang, Tianci An, Imran Tarique, Waseem Ail Vistro, Yifei Liu, Ziyu Wang, Haiyan Zhang, YongHong Shi, Abdul haseeb, Noor Samad Gandahi, Adeela Iqba, Huan Yang, Qiusheng Chen, Ping Yang
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-26T09:00:36Z
      DOI: 10.1177/0963689719842514
       
  • The Pros and Cons of Mesenchymal Stem Cell-Based Therapies

    • Authors: Aleksandra Musiał-Wysocka, Marta Kot, Marcin Majka
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-25T06:24:25Z
      DOI: 10.1177/0963689719837897
       
  • Clinical Assessment of Intravenous Endothelial Progenitor Cell
           Transplantation in Dogs

    • Authors: Seok Hee Lee, Jeong Chan Ra, Hyun Ju Oh, Min Jung Kim, Erif maha Nugraha Setyawan, Yoo Bin Choi, Jung Won Yang, Sung Keun Kang, Seung Hyup Han, Geon A Kim, Byeong Chun Lee
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-25T06:24:24Z
      DOI: 10.1177/0963689718821686
       
  • Combined Microsurgery and Endovascular Intervention in One-Stop for
           Treatment of Cerebral Arteriovenous Malformation: The Efficacy of a Hybrid
           Operation

    • Authors: Jun Wen, Jie Lu, Xiaojun Wu, Fanfan Chen, Ning Li, Hua He, Xiangyu Wang
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-25T06:24:24Z
      DOI: 10.1177/0963689719845366
       
  • Co-Transplantation of Human Umbilical Cord Mesenchymal Stem Cells and
           Human Neural Stem Cells Improves the Outcome in Rats with Spinal Cord
           Injury

    • Authors: Lei Sun, Fan Wang, Heng Chen, Dong Liu, Tingyu Qu, Xiaofeng Li, Daxia Xu, Feng Liu, Zhanmin Yin, Yunzhen Chen
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-23T10:40:45Z
      DOI: 10.1177/0963689719844525
       
  • Bexarotene Exerts Protective Effects Through Modulation of the Cerebral
           Vascular Smooth Muscle Cell Phenotypic Transformation by Regulating
           PPARγ/FLAP/LTB4 After Subarachnoid Hemorrhage in Rats

    • Authors: Zhaosi Zhang, Guosheng Zhao, Liu Liu, Junchi He, Rami Darwazeh, Han Liu, Hong Chen, Chao Zhou, Zongduo Guo, Xiaochuan Sun
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-23T04:47:46Z
      DOI: 10.1177/0963689719842161
       
  • Quantitative Analysis of SSEA3+ Cells from Human Umbilical Cord after
           Magnetic Sorting

    • Authors: Zikuan Leng, Dongming Sun, Zihao Huang, Iman Tadmori, Ning Chiang, Nikhit Kethidi, Ahmed Sabra, Yoshihiro Kushida, Yu-Show Fu, Mari Dezawa, Xijing He, Wise Young
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-18T12:11:15Z
      DOI: 10.1177/0963689719844260
       
  • The Effect of Enzymatic Digestion on Cultured Epithelial Autografts

    • Authors: M. Skog, Petter Sivlér, Ingrid Steinvall, Daniel Aili, Folke Sjöberg, Moustafa Elmasry
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-15T11:36:53Z
      DOI: 10.1177/0963689719833305
       
  • Plaque Distribution of Basilar Artery Fenestration by 3D High-Resolution
           MR Vessel Wall Imaging

    • Authors: Lei Liu, Xue-Bin Zhang, Shuo Lu, Zun-Jing Liu, Xian-Jin Zhu
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-15T11:36:53Z
      DOI: 10.1177/0963689719843813
       
  • The Preconditioning of Busulfan Promotes Efficiency of Human CD133+ Cells
           Engraftment in NOD Shi-SCID IL2Rγcnull (NOG) Mice via Intra-Bone Marrow
           Injection

    • Authors: Xiaofang Guo, Xiaoxiao Yin, Wenjuan Zhu, Ying Pan, Hui Wang, Yinming Liang, Xiaofei Zhu
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-15T11:36:52Z
      DOI: 10.1177/0963689719842162
       
  • Immunophenotype and Immune-Modulatory Activities of Human Fetal
           Cartilage-Derived Progenitor Cells

    • Authors: Su Jeong Lee, Jiyoung Kim, Woo Hee Choi, So Ra Park, Byung Hyune Choi, Byoung-Hyun Min
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-15T05:51:18Z
      DOI: 10.1177/0963689719842166
       
  • MicroRNA-133a and Myocardial Infarction

    • Authors: Yi Xiao, Jiling Zhao, Julian P. Tuazon, Cesar V. Borlongan, Guolong Yu
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-15T05:51:17Z
      DOI: 10.1177/0963689719843806
       
  • Potential Roles of NIX/BNIP3L Pathway in Rat Traumatic Brain Injury

    • Authors: Jialing Ma, Haibo Ni, Qin Rui, Huixiang Liu, Feng Jiang, Rong Gao, Yanping Gao, Di Li, Gang Chen
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-09T05:24:32Z
      DOI: 10.1177/0963689719840353
       
  • Circular RNAs: Diversity of Functions and a Regulatory Nova in Oral
           Medicine: A Pilot Review

    • Authors: Hong Wang, Cheng Feng, Meng Wang, Shuangyan Yang, Fulan Wei
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-04T09:09:56Z
      DOI: 10.1177/0963689719837917
       
  • Association between Non-Alcoholic Fatty Liver Disease and Intracerebral
           Hemorrhage

    • Authors: Sheng Tu, Ruihong Zhao, Hong Fang, Li Wang, Anwen Shao, Jifang Sheng
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-03-29T07:52:21Z
      DOI: 10.1177/0963689719840025
       
  • Long-Term Outcomes of BMMSC Compared with BMMNC for Treatment of Critical
           Limb Ischemia and Foot Ulcer in Patients with Diabetes

    • Authors: Debin Lu, Youzhao Jiang, Wuquan Deng, Yan Zhang, Ziwen Liang, Qinan Wu, Xiaoyan Jiang, Ling Zhang, Fang Gao, Ying Cao, Bing Chen, Yaoming Xue
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-03-28T05:23:04Z
      DOI: 10.1177/0963689719835177
       
  • Optimized Generation of Primary Human Epithelial Cells from Larynx and
           Hypopharynx: A Site-Specific Epithelial Model for Reflux Research

    • Authors: Ting-Ting Mo, Jia-Jie Tan, Mei-Gui Wang, Yuan-Feng Dai, Xiong Liu, Xiang-Ping Li
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-03-28T05:23:04Z
      DOI: 10.1177/0963689719838478
       
  • In Situ Cross-linking Hydrogel as a Vehicle for Retinal Progenitor Cell
           Transplantation

    • Authors: Jeayoung Park, Petr Baranov, Aybike Aydin, Hany Abdelgawad, Deepti Singh, Wanting Niu, Motoichi Kurisawa, Myron Spector, Michael J. Young
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-03-28T05:23:03Z
      DOI: 10.1177/0963689719825614
       
  • Evaluation of Diffusional Kurtosis Imaging in Sub-acute Ischemic Stroke:
           Comparison with Rehabilitation Treatment Effect

    • Authors: C Li, C Lan, X Zhang, L Yin, X Hao, J Tian, L Lin, H Sun, Z Yao, X Feng, J Jia, Y Yang
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-03-25T11:24:09Z
      DOI: 10.1177/0963689719837919
       
  • The Autonomic Innervation and Uterine Telocyte Interplay in Leiomyoma
           Formation

    • Authors: Veronika Aleksandrovych, Magdalena Kurnik-Łucka, Tomasz Bereza, Magdalena Białas, Artur Pasternak, Dragos Cretoiu, Jerzy A. Walocha, Krzysztof Gil
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-03-07T07:14:07Z
      DOI: 10.1177/0963689719833303
       
  • Sodium/Hydrogen Exchanger 1 Participates in Early Brain Injury after
           Subarachnoid Hemorrhage both in vivo and in vitro via Promoting Neuronal
           Apoptosis

    • Authors: Huangcheng Song, Shuai Yuan, Zhuwei Zhang, Juyi Zhang, Peng Zhang, Jie Cao, Haiying Li, Xiang Li, Haitao Shen, Zhong Wang, Gang Chen
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-03-06T10:54:00Z
      DOI: 10.1177/0963689719834873
       
  • Lycium barbarum (Wolfberry) Increases Retinal Ganglion Cell Survival and
           Affects both Microglia/Macrophage Polarization and Autophagy after Rat
           Partial Optic Nerve Transection

    • Authors: Hong-Ying Li, Mi Huang, Qiu-Yan Luo, Xi Hong, Seeram Ramakrishna, Kwok-Fai So
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-03-06T10:53:36Z
      DOI: 10.1177/0963689719835181
       
  • Repetitive Transcranial Magnetic Stimulation Promotes Neural Stem Cell
           Proliferation and Differentiation after Intracerebral Hemorrhage in Mice

    • Authors: Mengchu Cui, Hongfei Ge, Han Zeng, Hongxiang Yan, Le Zhang, Hua Feng, Yujie Chen
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-03-05T07:30:03Z
      DOI: 10.1177/0963689719834870
       
  • Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology,
           and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of
           Cerebral Microbleeds

    • Authors: Li Gong, Xiangzhu Tian, Jing Zhou, Qiong Dong, Yan Tan, You Lu, Jiayan Wu, Yanxin Zhao, Xueyuan Liu
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-02-19T05:57:01Z
      DOI: 10.1177/0963689719831707
       
  • Novel Insights into MSK1 Phosphorylation by MRKβ in Intracerebral
           Hemorrhage-Induced Neuronal Apoptosis

    • Authors: Peipei Gong, Rui Jiang, Junzhong Yao, Qi Yao, Xide Xu, Jian Chen, Jianhong Shen, Wei Shi
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-02-12T05:41:52Z
      DOI: 10.1177/0963689719829073
       
  • Pathophysiology of Ganglioside GM1 in Ischemic Stroke: Ganglioside GM1: A
           Critical Review

    • Authors: Wenchao Zhang, Paul R. Krafft, Tianlong Wang, John H. Zhang, Li Li, Jiping Tang
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-01-22T11:24:09Z
      DOI: 10.1177/0963689718822782
       
  • Delta Opioid Peptide [d-Ala2, d-Leu5] Enkephalin (DADLE) Exerts a
           Cytoprotective Effect in Astrocytes Exposed to Oxygen-Glucose Deprivation
           by Inducing Autophagy

    • Authors: Shuyan Wang, Xiaoqiong Cao, Yale Duan, Guangming Zhang
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-01-22T11:24:02Z
      DOI: 10.1177/0963689719825619
       
  • Bridging Therapy Versus Direct Mechanical Thrombectomy in Patients with
           Acute Ischemic Stroke due to Middle Cerebral Artery Occlusion: A
           Clinical-Histological Analysis of Retrieved Thrombi

    • Authors: Li Gong, Xiaoran Zheng, Lijin Feng, Xiang Zhang, Qiong Dong, Xiaoyu Zhou, Haichao Wang, Xiaojun Zhang, Zhongwen Shu, Yanxin Zhao, Xueyuan Liu
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-01-18T10:02:16Z
      DOI: 10.1177/0963689718823206
       
  • Treatment Strategy for Unruptured Intracranial Aneurysm in Elderly
           Patients: Coiling, Clipping, or Conservative'

    • Authors: H. Yang, H. Jiang, W. Ni, B. Leng, X. Bin, G. Chen, Y. Tian, Y. Gu
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-01-16T11:38:59Z
      DOI: 10.1177/0963689718823517
       
  • Administration of rCTRP9 Attenuates Neuronal Apoptosis Through
           AdipoR1/PI3K/Akt Signaling Pathway after ICH in Mice

    • Authors: Lianhua Zhao, John H. Zhang, Prativa Sherchan, Paul R. Krafft, Wei Zhao, Sa Wang, Shengpan Chen, Zaiyu Guo, Jiping Tang
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-01-15T06:42:02Z
      DOI: 10.1177/0963689718822809
       
  • The Role of Hypoxia on the Neuronal Differentiation of Gingival
           Mesenchymal Stem Cells: A Transcriptional Study

    • Authors: Agnese Gugliandolo, Francesca Diomede, Domenico Scionti, Placido Bramanti, Oriana Trubiani, Emanuela Mazzon
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-01-15T06:41:47Z
      DOI: 10.1177/0963689718814470
       
  • CDNF Protein Therapy in Parkinson’s Disease

    • Authors: Henri J. Huttunen, Mart Saarma
      First page: 349
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-05T05:38:52Z
      DOI: 10.1177/0963689719840290
       
  • Endothelial Progenitor Cells Conditioned Medium Supports Number of
           GABAergic Neurons and Exerts Neuroprotection in Cultured Striatal Neuronal
           Progenitor Cells

    • Authors: Stefano Di Santo, Stefanie Seiler, Robert Andres, Hans Rudolf Widmer
      First page: 367
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-24T01:48:45Z
      DOI: 10.1177/0963689719835192
       
  • α-Synuclein Expression Is Preserved in Substantia Nigra GABAergic Fibers
           of Young and Aged Neurotoxin-Treated Rhesus Monkeys

    • Authors: Scott C. Vermilyea, Scott Guthrie, Iliana Hernandez, Viktorya Bondarenko, Marina E. Emborg
      First page: 379
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-03-12T06:27:43Z
      DOI: 10.1177/0963689719835794
       
  • Transplanting Cells for Spinal Cord Repair: Who, What, When, Where and
           Why'

    • Authors: Lyandysha V. Zholudeva, Michael A. Lane
      First page: 388
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-01-18T10:02:10Z
      DOI: 10.1177/0963689718824097
       
  • The Effect of iPS-Derived Neural Progenitors Seeded on Laminin-Coated
           pHEMA-MOETACl Hydrogel with Dual Porosity in a Rat Model of Chronic Spinal
           Cord Injury

    • Authors: Jiri Ruzicka, Nataliya Romanyuk, Klara Jirakova, Ales Hejcl, Olga Janouskova, Lucia Urdzikova Machova, Marcel Bochin, Martin Pradny, Lydia Vargova, Pavla Jendelova
      First page: 400
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-01-18T10:02:39Z
      DOI: 10.1177/0963689718823705
       
  • Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated
           Cell Therapy

    • Authors: Emilia Galli, Päivi Lindholm, Leena-Stiina Kontturi, Mart Saarma, Arto Urtti, Marjo Yliperttula
      First page: 413
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-03-07T07:13:59Z
      DOI: 10.1177/0963689719827943
       
  • Secondary Pathology of the Thalamus after Focal Cortical Stroke in Rats is
           not Associated with Thermal or Mechanical Hypersensitivity and is Not
           Alleviated by Intra-Thalamic Post-Stroke Delivery of Recombinant CDNF or
           MANF

    • Authors: Jenni E. Anttila, Suvi Pöyhönen, Mikko Airavaara
      First page: 425
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-30T09:50:05Z
      DOI: 10.1177/0963689719837915
       
  • Pomalidomide Reduces Ischemic Brain Injury in Rodents

    • Authors: Yan-Rou Tsai, David Tweedie, Ignacio Navas-Enamorado, Michael T. Scerba, Cheng-Fu Chang, Jing-Huei Lai, John Chung-Che Wu, Yen-Hua Chen, Shuo-Jhen Kang, Barry J. Hoffer, Rafael de Cabo, Nigel H. Greig, Yung-Hsiao Chiang, Kai-Yun Chen
      First page: 439
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-05-16T09:56:08Z
      DOI: 10.1177/0963689719850078
       
  • Functional Multipotency of Stem Cells and Recovery Neurobiology of Injured
           Spinal Cords

    • Authors: Yang D. Teng
      First page: 451
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-05-28T10:11:33Z
      DOI: 10.1177/0963689719850088
       
  • Silencing of the Mutant Huntingtin Gene through CRISPR-Cas9 Improves the
           Mitochondrial Biomarkers in an In Vitro Model of Huntington’s Disease

    • Authors: Gary L. Dunbar, Sindhuja Koneru, Nivya Kolli, Michael Sandstrom, Panchanan Maiti, Julien Rossignol
      First page: 460
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-05T05:38:52Z
      DOI: 10.1177/0963689719840662
       
  • ASNTR Abstracts 2019

    • First page: 464
      Abstract: Cell Transplantation, Ahead of Print.

      Citation: Cell Transplantation
      PubDate: 2019-04-23T11:33:53Z
      DOI: 10.1177/0963689719837446
       
 
 
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