Authors:Kim Donati, Christelle Sépult, Natacha Rocks, Silvia Blacher, Catherine Gérard, Agnès Noel, Didier Cataldo Abstract: The premetastatic niche in distant organs prior to metastatic cell arrival emerged as an important step in the metastatic cascade. However, molecular mechanisms underlying this process are still poorly understood. In particular, whether neutrophil recruitment at a premetastatic stage promotes or inhibits metastatic cell seeding has to be clarified. We aimed at unraveling how neutrophil infiltr ... Citation: Cancer Growth and Metastasis 2017:10 1179064417738513 PubDate: 2017-10-27T00:00:00-05:00 DOI: 10.4137/CGM.S42295 Issue No:Vol. 2017, No. 1 (2017)
Authors:Tanja Grimmig, Eva-Maria Moll, Kerstin Kloos, Rebecca Thumm, Romana Moench, Simone Callies, Jennifer Kreckel, Malte Vetterlein, Joerg Pelz, Buelent Polat, Sudipta Tripathi, Roberta Rehder, Carmen M Ribas, Anil Chandraker, Christoph-T Germer, Ana Maria Waaga-Gasser, Martin Gasser Abstract: In patients with peritoneal carcinomatosis cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) represents a promising treatment strategy. Here, we studied the role of hyperthermic chemotherapy on heat shock protein (HSP) expression and induction of tumor cell death and survival. HSP27, HSP70, and HSP90 combined with effects on tumor cell proliferation and chem ... Citation: Cancer Growth and Metastasis 2017:10 1179064417730559 PubDate: 2017-09-18T00:00:00-05:00 DOI: 10.4137/CGM.S42156 Issue No:Vol. 2017, No. 1 (2017)
Authors:John K Cowell, Yong Teng, N George Bendzunas, Roxan Ara, Ali S Arbab, Eileen J Kennedy Abstract: The WASF3 gene facilitates the metastatic phenotype, and its inactivation leads to suppression of invasion and metastasis regardless of the genetic background of the cancer cell. This reliance on WASF3 to facilitate metastasis suggests that targeting its function could serve as an effective strategy to suppress metastasis. WASF3 stability and function are regulated by the WASF Regulatory Compl ... Citation: Cancer Growth and Metastasis 2017:10 1179064417713197 PubDate: 2017-06-19T00:00:00-05:00 DOI: 10.4137/CGM.S41769 Issue No:Vol. 2017, No. 1 (2017)
Authors:Farid G Khalafalla, Mohammad W Khan Abstract: Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and one of the most lethal human cancers. Inflammation is a critical component in PDAC initiation and progression. Inflammation also contributes to the aggressiveness of PDAC indirectly via induction of epithelial-mesenchymal transition (EMT), altogether leading to enhanced resistance to chemotherapy and poor ... Citation: Cancer Growth and Metastasis 2017:10 1179064417709287 PubDate: 2017-05-15T00:00:00-05:00 DOI: 10.4137/CGM.S38051 Issue No:Vol. 2017, No. 1 (2017)
Authors:Satya S. Sadhu, Shenggang. Wang, Rakesh. Dachineni, Ranjith Kumar. Averineni, Yang. Yang, Huihui. Yin, G Jayarama. Bhat, Xiangming. Guan Abstract: Glutathione disulfide (GSSG) is an endogenous peptide and the oxidized form of glutathione. The impacts of GSSG on cell function/dysfunction remain largely unexplored due to a lack of method to specifically increase intracellular GSSG. We recently developed GSSG liposomes that can specifically increase intracellular GSSG. The increase affected 3 of the 4 essential steps (cell detachment, migra ... Citation: Cancer Growth and Metastasis 2017:10 1179064417696070 PubDate: 2017-03-10T00:00:00-06:00 DOI: 10.4137/CGM.S40928 Issue No:Vol. 2017, No. 1 (2017)
Authors:Satya S. Sadhu, Shenggang. Wang, Rakesh. Dachineni, Ranjith Kumar. Averineni, Teresa. Seefeldt, Jiashu. Xie, Hemachand. Tummala, G Jayarama. Bhat, Xiangming. Guan Abstract: Cancer metastasis is the major cause of cancer mortality. Despite extensive research efforts, effective treatment for cancer metastasis is still lacking. Cancer metastasis involves 4 essential steps: cell detachment, migration, invasion, and adhesion. Detachment is the first and required step for metastasis. Glutathione disulfide (GSSG) is derived from the oxidation of glutathione (GSH), which ... Citation: Cancer Growth and Metastasis 2017:10 1179064417695255 PubDate: 2017-03-08T00:00:00-06:00 DOI: 10.4137/CGM.S40926 Issue No:Vol. 2017, No. 1 (2017)
Authors:Ahmed M. Abd El-Aziz, Eman A. Ibrahim, Ashraf. Abd-Elmoghny, Mohammed. El-Bassiouny, Zina M. Laban, Somaia A. Saad El-Din, Youhanna. Shohdy Abstract: Background:Gastrointestinal stromal tumor (GIST) is a relatively rare type of neoplasms. In Egypt, it represents 2.5% of gastrointestinal tumors and 0.3% of all malignancies. Most of the GISTs develop in the stomach.Aim:To reveal the significance of Her2/neu immunohistochemical expression in GIST and its correlation with other histopathologic parameters and tumor rel ... Citation: Cancer Growth and Metastasis 2017:10 1179064417690543 PubDate: 2017-02-16T00:00:00-06:00 DOI: 10.4137/CGM.S39546 Issue No:Vol. 2017, No. 1 (2017)
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