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Publisher: Oxford University Press   (Total: 370 journals)

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Showing 1 - 200 of 370 Journals sorted alphabetically
Acta Biochimica et Biophysica Sinica     Hybrid Journal   (Followers: 6, SJR: 0.881, h-index: 38)
Adaptation     Hybrid Journal   (Followers: 9, SJR: 0.111, h-index: 4)
Aesthetic Surgery J.     Hybrid Journal   (Followers: 6, SJR: 1.538, h-index: 35)
African Affairs     Hybrid Journal   (Followers: 60, SJR: 1.512, h-index: 46)
Age and Ageing     Hybrid Journal   (Followers: 86, SJR: 1.611, h-index: 107)
Alcohol and Alcoholism     Hybrid Journal   (Followers: 18, SJR: 0.935, h-index: 80)
American Entomologist     Full-text available via subscription   (Followers: 6)
American Historical Review     Hybrid Journal   (Followers: 148, SJR: 0.652, h-index: 43)
American J. of Agricultural Economics     Hybrid Journal   (Followers: 39, SJR: 1.441, h-index: 77)
American J. of Epidemiology     Hybrid Journal   (Followers: 173, SJR: 3.047, h-index: 201)
American J. of Hypertension     Hybrid Journal   (Followers: 25, SJR: 1.397, h-index: 111)
American J. of Jurisprudence     Hybrid Journal   (Followers: 18)
American J. of Legal History     Full-text available via subscription   (Followers: 7, SJR: 0.151, h-index: 7)
American Law and Economics Review     Hybrid Journal   (Followers: 27, SJR: 0.824, h-index: 23)
American Literary History     Hybrid Journal   (Followers: 13, SJR: 0.185, h-index: 22)
Analysis     Hybrid Journal   (Followers: 23)
Annals of Botany     Hybrid Journal   (Followers: 35, SJR: 1.912, h-index: 124)
Annals of Occupational Hygiene     Hybrid Journal   (Followers: 28, SJR: 0.837, h-index: 57)
Annals of Oncology     Hybrid Journal   (Followers: 48, SJR: 4.362, h-index: 173)
Annals of the Entomological Society of America     Full-text available via subscription   (Followers: 8, SJR: 0.642, h-index: 53)
Annals of Work Exposures and Health     Hybrid Journal  
AoB Plants     Open Access   (Followers: 4, SJR: 0.78, h-index: 10)
Applied Economic Perspectives and Policy     Hybrid Journal   (Followers: 19, SJR: 0.884, h-index: 31)
Applied Linguistics     Hybrid Journal   (Followers: 53, SJR: 1.749, h-index: 63)
Applied Mathematics Research eXpress     Hybrid Journal   (Followers: 1, SJR: 0.779, h-index: 11)
Arbitration Intl.     Full-text available via subscription   (Followers: 20)
Arbitration Law Reports and Review     Hybrid Journal   (Followers: 13)
Archives of Clinical Neuropsychology     Hybrid Journal   (Followers: 27, SJR: 0.96, h-index: 71)
Aristotelian Society Supplementary Volume     Hybrid Journal   (Followers: 2, SJR: 0.102, h-index: 20)
Arthropod Management Tests     Hybrid Journal   (Followers: 2)
Astronomy & Geophysics     Hybrid Journal   (Followers: 45, SJR: 0.144, h-index: 15)
Behavioral Ecology     Hybrid Journal   (Followers: 51, SJR: 1.698, h-index: 92)
Bioinformatics     Hybrid Journal   (Followers: 298, SJR: 4.643, h-index: 271)
Biology Methods and Protocols     Hybrid Journal  
Biology of Reproduction     Full-text available via subscription   (Followers: 9, SJR: 1.646, h-index: 149)
Biometrika     Hybrid Journal   (Followers: 20, SJR: 2.801, h-index: 90)
BioScience     Hybrid Journal   (Followers: 30, SJR: 2.374, h-index: 154)
Bioscience Horizons : The National Undergraduate Research J.     Open Access   (Followers: 1, SJR: 0.213, h-index: 9)
Biostatistics     Hybrid Journal   (Followers: 16, SJR: 1.955, h-index: 55)
BJA : British J. of Anaesthesia     Hybrid Journal   (Followers: 160, SJR: 2.314, h-index: 133)
BJA Education     Hybrid Journal   (Followers: 65, SJR: 0.272, h-index: 20)
Brain     Hybrid Journal   (Followers: 63, SJR: 6.097, h-index: 264)
Briefings in Bioinformatics     Hybrid Journal   (Followers: 45, SJR: 4.086, h-index: 73)
Briefings in Functional Genomics     Hybrid Journal   (Followers: 4, SJR: 1.771, h-index: 50)
British J. for the Philosophy of Science     Hybrid Journal   (Followers: 35, SJR: 1.267, h-index: 38)
British J. of Aesthetics     Hybrid Journal   (Followers: 27, SJR: 0.217, h-index: 18)
British J. of Criminology     Hybrid Journal   (Followers: 565, SJR: 1.373, h-index: 62)
British J. of Social Work     Hybrid Journal   (Followers: 84, SJR: 0.771, h-index: 53)
British Medical Bulletin     Hybrid Journal   (Followers: 7, SJR: 1.391, h-index: 84)
British Yearbook of Intl. Law     Hybrid Journal   (Followers: 29)
Bulletin of the London Mathematical Society     Hybrid Journal   (Followers: 3, SJR: 1.474, h-index: 31)
Cambridge J. of Economics     Hybrid Journal   (Followers: 59, SJR: 0.957, h-index: 59)
Cambridge J. of Regions, Economy and Society     Hybrid Journal   (Followers: 10, SJR: 1.067, h-index: 22)
Cambridge Quarterly     Hybrid Journal   (Followers: 11, SJR: 0.1, h-index: 7)
Capital Markets Law J.     Hybrid Journal   (Followers: 1)
Carcinogenesis     Hybrid Journal   (Followers: 2, SJR: 2.439, h-index: 167)
Cardiovascular Research     Hybrid Journal   (Followers: 12, SJR: 2.897, h-index: 175)
Cerebral Cortex     Hybrid Journal   (Followers: 44, SJR: 4.827, h-index: 192)
CESifo Economic Studies     Hybrid Journal   (Followers: 17, SJR: 0.501, h-index: 19)
Chemical Senses     Hybrid Journal   (Followers: 1, SJR: 1.436, h-index: 76)
Children and Schools     Hybrid Journal   (Followers: 6, SJR: 0.211, h-index: 18)
Chinese J. of Comparative Law     Hybrid Journal   (Followers: 3)
Chinese J. of Intl. Law     Hybrid Journal   (Followers: 21, SJR: 0.737, h-index: 11)
Chinese J. of Intl. Politics     Hybrid Journal   (Followers: 9, SJR: 1.238, h-index: 15)
Christian Bioethics: Non-Ecumenical Studies in Medical Morality     Hybrid Journal   (Followers: 11, SJR: 0.191, h-index: 8)
Classical Receptions J.     Hybrid Journal   (Followers: 24, SJR: 0.1, h-index: 3)
Clinical Infectious Diseases     Hybrid Journal   (Followers: 63, SJR: 4.742, h-index: 261)
Clinical Kidney J.     Open Access   (Followers: 4, SJR: 0.338, h-index: 19)
Community Development J.     Hybrid Journal   (Followers: 24, SJR: 0.47, h-index: 28)
Computer J.     Hybrid Journal   (Followers: 9, SJR: 0.371, h-index: 47)
Conservation Physiology     Open Access   (Followers: 2)
Contemporary Women's Writing     Hybrid Journal   (Followers: 11, SJR: 0.111, h-index: 3)
Contributions to Political Economy     Hybrid Journal   (Followers: 5, SJR: 0.313, h-index: 10)
Critical Values     Full-text available via subscription  
Current Legal Problems     Hybrid Journal   (Followers: 26)
Current Zoology     Full-text available via subscription   (Followers: 1, SJR: 0.999, h-index: 20)
Database : The J. of Biological Databases and Curation     Open Access   (Followers: 10, SJR: 1.068, h-index: 24)
Digital Scholarship in the Humanities     Hybrid Journal   (Followers: 13)
Diplomatic History     Hybrid Journal   (Followers: 19, SJR: 0.296, h-index: 22)
DNA Research     Open Access   (Followers: 5, SJR: 2.42, h-index: 77)
Dynamics and Statistics of the Climate System     Open Access   (Followers: 3)
Early Music     Hybrid Journal   (Followers: 15, SJR: 0.124, h-index: 11)
Economic Policy     Hybrid Journal   (Followers: 38, SJR: 2.052, h-index: 52)
ELT J.     Hybrid Journal   (Followers: 25, SJR: 1.26, h-index: 23)
English Historical Review     Hybrid Journal   (Followers: 55, SJR: 0.311, h-index: 10)
English: J. of the English Association     Hybrid Journal   (Followers: 13, SJR: 0.144, h-index: 3)
Environmental Entomology     Full-text available via subscription   (Followers: 11, SJR: 0.791, h-index: 66)
Environmental Epigenetics     Open Access   (Followers: 2)
Environmental History     Hybrid Journal   (Followers: 28, SJR: 0.197, h-index: 25)
EP-Europace     Hybrid Journal   (Followers: 2, SJR: 2.201, h-index: 71)
Epidemiologic Reviews     Hybrid Journal   (Followers: 9, SJR: 3.917, h-index: 81)
ESHRE Monographs     Hybrid Journal  
Essays in Criticism     Hybrid Journal   (Followers: 16, SJR: 0.1, h-index: 6)
European Heart J.     Hybrid Journal   (Followers: 52, SJR: 6.997, h-index: 227)
European Heart J. - Cardiovascular Imaging     Hybrid Journal   (Followers: 8, SJR: 2.044, h-index: 58)
European Heart J. - Cardiovascular Pharmacotherapy     Full-text available via subscription   (Followers: 1)
European Heart J. - Quality of Care and Clinical Outcomes     Hybrid Journal  
European Heart J. Supplements     Hybrid Journal   (Followers: 7, SJR: 0.152, h-index: 31)
European J. of Cardio-Thoracic Surgery     Hybrid Journal   (Followers: 8, SJR: 1.568, h-index: 104)
European J. of Intl. Law     Hybrid Journal   (Followers: 173, SJR: 0.722, h-index: 38)
European J. of Orthodontics     Hybrid Journal   (Followers: 4, SJR: 1.09, h-index: 60)
European J. of Public Health     Hybrid Journal   (Followers: 23, SJR: 1.284, h-index: 64)
European Review of Agricultural Economics     Hybrid Journal   (Followers: 11, SJR: 1.549, h-index: 42)
European Review of Economic History     Hybrid Journal   (Followers: 29, SJR: 0.628, h-index: 24)
European Sociological Review     Hybrid Journal   (Followers: 41, SJR: 2.061, h-index: 53)
Evolution, Medicine, and Public Health     Open Access   (Followers: 11)
Family Practice     Hybrid Journal   (Followers: 12, SJR: 1.048, h-index: 77)
Fems Microbiology Ecology     Hybrid Journal   (Followers: 9, SJR: 1.687, h-index: 115)
Fems Microbiology Letters     Hybrid Journal   (Followers: 21, SJR: 1.126, h-index: 118)
Fems Microbiology Reviews     Hybrid Journal   (Followers: 26, SJR: 7.587, h-index: 150)
Fems Yeast Research     Hybrid Journal   (Followers: 14, SJR: 1.213, h-index: 66)
Foreign Policy Analysis     Hybrid Journal   (Followers: 22, SJR: 0.859, h-index: 10)
Forestry: An Intl. J. of Forest Research     Hybrid Journal   (Followers: 15, SJR: 0.903, h-index: 44)
Forum for Modern Language Studies     Hybrid Journal   (Followers: 6, SJR: 0.108, h-index: 6)
French History     Hybrid Journal   (Followers: 32, SJR: 0.123, h-index: 10)
French Studies     Hybrid Journal   (Followers: 20, SJR: 0.119, h-index: 7)
French Studies Bulletin     Hybrid Journal   (Followers: 10, SJR: 0.102, h-index: 3)
Gastroenterology Report     Open Access   (Followers: 2)
Genome Biology and Evolution     Open Access   (Followers: 12, SJR: 3.22, h-index: 39)
Geophysical J. Intl.     Hybrid Journal   (Followers: 35, SJR: 1.839, h-index: 119)
German History     Hybrid Journal   (Followers: 27, SJR: 0.437, h-index: 13)
GigaScience     Open Access   (Followers: 3)
Global Summitry     Hybrid Journal  
Glycobiology     Hybrid Journal   (Followers: 14, SJR: 1.692, h-index: 101)
Health and Social Work     Hybrid Journal   (Followers: 52, SJR: 0.505, h-index: 40)
Health Education Research     Hybrid Journal   (Followers: 14, SJR: 0.814, h-index: 80)
Health Policy and Planning     Hybrid Journal   (Followers: 22, SJR: 1.628, h-index: 66)
Health Promotion Intl.     Hybrid Journal   (Followers: 21, SJR: 0.664, h-index: 60)
History Workshop J.     Hybrid Journal   (Followers: 29, SJR: 0.313, h-index: 20)
Holocaust and Genocide Studies     Hybrid Journal   (Followers: 26, SJR: 0.115, h-index: 13)
Human Molecular Genetics     Hybrid Journal   (Followers: 9, SJR: 4.288, h-index: 233)
Human Reproduction     Hybrid Journal   (Followers: 80, SJR: 2.271, h-index: 179)
Human Reproduction Update     Hybrid Journal   (Followers: 19, SJR: 4.678, h-index: 128)
Human Rights Law Review     Hybrid Journal   (Followers: 62, SJR: 0.7, h-index: 21)
ICES J. of Marine Science: J. du Conseil     Hybrid Journal   (Followers: 54, SJR: 1.233, h-index: 88)
ICSID Review     Hybrid Journal   (Followers: 11)
ILAR J.     Hybrid Journal   (Followers: 1, SJR: 1.099, h-index: 51)
IMA J. of Applied Mathematics     Hybrid Journal   (SJR: 0.329, h-index: 26)
IMA J. of Management Mathematics     Hybrid Journal   (Followers: 1, SJR: 0.351, h-index: 20)
IMA J. of Mathematical Control and Information     Hybrid Journal   (Followers: 2, SJR: 0.661, h-index: 28)
IMA J. of Numerical Analysis - advance access     Hybrid Journal   (SJR: 2.032, h-index: 44)
Industrial and Corporate Change     Hybrid Journal   (Followers: 9, SJR: 1.37, h-index: 81)
Industrial Law J.     Hybrid Journal   (Followers: 32, SJR: 0.184, h-index: 15)
Information and Inference     Free  
Integrative and Comparative Biology     Hybrid Journal   (Followers: 8, SJR: 1.911, h-index: 90)
Interacting with Computers     Hybrid Journal   (Followers: 11, SJR: 0.529, h-index: 59)
Interactive CardioVascular and Thoracic Surgery     Hybrid Journal   (Followers: 5, SJR: 0.743, h-index: 35)
Intl. Affairs     Hybrid Journal   (Followers: 52, SJR: 1.264, h-index: 53)
Intl. Data Privacy Law     Hybrid Journal   (Followers: 30)
Intl. Health     Hybrid Journal   (Followers: 5, SJR: 0.835, h-index: 15)
Intl. Immunology     Hybrid Journal   (Followers: 3, SJR: 1.613, h-index: 111)
Intl. J. for Quality in Health Care     Hybrid Journal   (Followers: 34, SJR: 1.593, h-index: 69)
Intl. J. of Constitutional Law     Hybrid Journal   (Followers: 61, SJR: 0.613, h-index: 19)
Intl. J. of Epidemiology     Hybrid Journal   (Followers: 158, SJR: 4.381, h-index: 145)
Intl. J. of Law and Information Technology     Hybrid Journal   (Followers: 4, SJR: 0.247, h-index: 8)
Intl. J. of Law, Policy and the Family     Hybrid Journal   (Followers: 29, SJR: 0.307, h-index: 15)
Intl. J. of Lexicography     Hybrid Journal   (Followers: 8, SJR: 0.404, h-index: 18)
Intl. J. of Low-Carbon Technologies     Open Access   (Followers: 1, SJR: 0.457, h-index: 12)
Intl. J. of Neuropsychopharmacology     Open Access   (Followers: 3, SJR: 1.69, h-index: 79)
Intl. J. of Public Opinion Research     Hybrid Journal   (Followers: 9, SJR: 0.906, h-index: 33)
Intl. J. of Refugee Law     Hybrid Journal   (Followers: 34, SJR: 0.231, h-index: 21)
Intl. J. of Transitional Justice     Hybrid Journal   (Followers: 13, SJR: 0.833, h-index: 12)
Intl. Mathematics Research Notices     Hybrid Journal   (Followers: 1, SJR: 2.052, h-index: 42)
Intl. Political Sociology     Hybrid Journal   (Followers: 32, SJR: 1.339, h-index: 19)
Intl. Relations of the Asia-Pacific     Hybrid Journal   (Followers: 18, SJR: 0.539, h-index: 17)
Intl. Studies Perspectives     Hybrid Journal   (Followers: 7, SJR: 0.998, h-index: 28)
Intl. Studies Quarterly     Hybrid Journal   (Followers: 40, SJR: 2.184, h-index: 68)
Intl. Studies Review     Hybrid Journal   (Followers: 18, SJR: 0.783, h-index: 38)
ISLE: Interdisciplinary Studies in Literature and Environment     Hybrid Journal   (Followers: 1, SJR: 0.155, h-index: 4)
ITNOW     Hybrid Journal   (Followers: 2, SJR: 0.102, h-index: 4)
J. of African Economies     Hybrid Journal   (Followers: 15, SJR: 0.647, h-index: 30)
J. of American History     Hybrid Journal   (Followers: 45, SJR: 0.286, h-index: 34)
J. of Analytical Toxicology     Hybrid Journal   (Followers: 14, SJR: 1.038, h-index: 60)
J. of Antimicrobial Chemotherapy     Hybrid Journal   (Followers: 14, SJR: 2.157, h-index: 149)
J. of Antitrust Enforcement     Hybrid Journal   (Followers: 1)
J. of Applied Poultry Research     Hybrid Journal   (Followers: 4, SJR: 0.563, h-index: 43)
J. of Biochemistry     Hybrid Journal   (Followers: 42, SJR: 1.341, h-index: 96)
J. of Chromatographic Science     Hybrid Journal   (Followers: 18, SJR: 0.448, h-index: 42)
J. of Church and State     Hybrid Journal   (Followers: 11, SJR: 0.167, h-index: 11)
J. of Competition Law and Economics     Hybrid Journal   (Followers: 36, SJR: 0.442, h-index: 16)
J. of Complex Networks     Hybrid Journal   (Followers: 1, SJR: 1.165, h-index: 5)
J. of Conflict and Security Law     Hybrid Journal   (Followers: 13, SJR: 0.196, h-index: 15)
J. of Consumer Research     Full-text available via subscription   (Followers: 43, SJR: 4.896, h-index: 121)
J. of Crohn's and Colitis     Hybrid Journal   (Followers: 10, SJR: 1.543, h-index: 37)
J. of Cybersecurity     Hybrid Journal   (Followers: 3)
J. of Deaf Studies and Deaf Education     Hybrid Journal   (Followers: 9, SJR: 0.69, h-index: 36)
J. of Design History     Hybrid Journal   (Followers: 18, SJR: 0.166, h-index: 14)
J. of Economic Entomology     Full-text available via subscription   (Followers: 6, SJR: 0.894, h-index: 76)
J. of Economic Geography     Hybrid Journal   (Followers: 24, SJR: 2.909, h-index: 69)
J. of Environmental Law     Hybrid Journal   (Followers: 24, SJR: 0.457, h-index: 20)
J. of European Competition Law & Practice     Hybrid Journal   (Followers: 20)
J. of Experimental Botany     Hybrid Journal   (Followers: 14, SJR: 2.798, h-index: 163)
J. of Financial Econometrics     Hybrid Journal   (Followers: 22, SJR: 1.314, h-index: 27)
J. of Global Security Studies     Hybrid Journal   (Followers: 4)
J. of Heredity     Hybrid Journal   (Followers: 4, SJR: 1.024, h-index: 76)
J. of Hindu Studies     Hybrid Journal   (Followers: 8, SJR: 0.186, h-index: 3)
J. of Hip Preservation Surgery     Open Access  
J. of Human Rights Practice     Hybrid Journal   (Followers: 20, SJR: 0.399, h-index: 10)
J. of Infectious Diseases     Hybrid Journal   (Followers: 41, SJR: 4, h-index: 209)
J. of Insect Science     Open Access   (Followers: 9, SJR: 0.388, h-index: 31)

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Journal Cover Interactive CardioVascular and Thoracic Surgery
  [SJR: 0.743]   [H-I: 35]   [5 followers]  Follow
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1569-9293 - ISSN (Online) 1569-9285
   Published by Oxford University Press Homepage  [370 journals]
  • New graft sizing rings for aortic valve reimplantation procedures†
    • Authors: Jelenc M; Jelenc B, Kneževič I, et al.
      First page: 1
      Abstract: AbstractOBJECTIVESThe objective was to design sizing rings that would enable proper sizing of the graft in reimplantation procedures and to perform leaflet repair before graft implantation.METHODSThe rings were designed in Autodesk Fusion 360 (San Rafael, CA, USA) and 3D printed using a commercial online 3D printing service. We designed incomplete rings with a low profile and complete rings with a high profile. The complete rings are best suited for reimplantation procedures, whereas low profile C rings are intended for isolated aortic valve repair, where the ascending aorta is not transected. The rings come in sizes corresponding to Vascutek Gelweave graft sizes (Vascutek Terumo, Renfrewshire, Scotland). The ring internal diameters are 5% larger than the designated ring sizes and account for the 5% stretch of the grafts when pressurized. Blades of the rings are placed at 20° intervals. The slits between the blades are designed in such a way that the commissural U-sutures, when put in place and under tension, will lock the ring in position.RESULTSThe rings were successfully used in 10 of our latest reimplantation procedures. After dissection of the aortic root, the commissures were suspended with U-stitches and then the ring was seated onto them. Complete leaflet repair with plication to achieve adequate effective height was then performed, followed by graft implantation. No additional leaflet repair was needed.CONCLUSIONSThe newly designed sizing rings enable proper sizing of the graft in reimplantation procedures and enable complete leaflet repair before graft implantation.
      PubDate: Fri, 11 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx257
  • Percutaneous left atrial unloading to prevent pulmonary oedema and to
           facilitate ventricular recovery under extracorporeal membrane oxygenation
    • Authors: Bernhardt A; Hillebrand M, Yildirim Y, et al.
      First page: 4
      Abstract: AbstractOBJECTIVESLeft-sided unloading during extracorporeal membrane oxygenation (ECMO) therapy is crucial to prevent pulmonary oedema and facilitate ventricular recovery. We present the case of a 55-year-old man under ECMO therapy with pre-existing left ventricular (LV) thrombus formation and in need of ventricular unloading.METHODSWe implanted a 21-Fr TandemHeart Protek Solo trans-septal cannula into the left atrium using a trans-septal approach via the femoral vein. The cannula was connected to the venous line of the ECMO circuit. A flow probe and a clamp to reduce flow, if necessary, were attached to the left atrium line. Left atrium flow was adjusted to 900 ml/min under transoesophageal echocardiography control to keep the atrial septum in the mid-line and to prevent suction of the inflow cannula.RESULTSAfter 9 days, the patient was weaned step-wise from ECMO and the TandemHeart cannula, which was then explanted. The patient is in New York health Association Class II without neurological sequelae (Cerebral Performance Scale 1). After 3 months, the patient has fully recovered and is working daily. The LV function is still moderately impaired, and the size of the LV thrombus remains the same. The atrial septum shows no residual defect.CONCLUSIONSPercutaneous trans-septal insertion of a TandemHeart cannula incorporated in an ECMO circuit for the prevention of pulmonary oedema and subsequent weaning from extracorporeal circulation was feasible and safe in a patient with cardiogenic shock and an LV thrombus.
      PubDate: Fri, 01 Sep 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx266
  • Establishing stable innominate access by inserting a body floss wire from
           the brachial artery to the femoral artery facilitates right carotid artery
           stenting in Type III arch anatomy†
    • Authors: Kuo M; Chen P, Shih C, et al.
      First page: 8
      Abstract: AbstractOBJECTIVESIn patients with severe carotid artery stenosis, the anatomy of their Type III aortic arch increases the difficulty and complication rates during carotid artery stenting because of its tortuosity and sharp angulation for cannulation as well as the unstable support of the guidewire for shuttle sheath delivery.METHODSWe demonstrate a novel technique to overcome these challenges, namely the creation of stable innominate artery access by inserting a through-and-through body floss wire from the right brachial artery to the femoral artery.RESULTSWe successfully performed right carotid artery stenting in 3 patients with Type III arch anatomy. All patients received regular outpatient follow-up uneventfully for more than 1 year.CONCLUSIONSThis facilitates the procedure of the right carotid artery stenting in patients with Type III aortic arch.
      PubDate: Thu, 17 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx273
  • eComment. The body floss wire technique - establishing a stable platform
           for right carotid artery stenting in hostile aortic arches
    • Authors: Mouawad N.
      First page: 10
      Abstract: I read with great interest the technical notes by Kuo and colleagues describing a method for establishing stable innominate access for carotid artery stenting in difficult type III aortic arches using a body floss wire technique [1]. The authors discuss a cases series of three patients undergoing a combined right transbrachial and transfemoral approach that resulted in a satisfactory platform for endovascular intervention of the right carotid artery with hostile aortic arch anatomy.
      PubDate: Tue, 19 Dec 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx322
  • High mortality in patients with tracheoarterial fistulas: clinical
           experience and treatment recommendations
    • Authors: Reger B; Neu R, Hofmann H, et al.
      First page: 12
      Abstract: AbstractOBJECTIVESA tracheoarterial fistula (TAF) is an uncommon but a critical complication of tracheostomy and represents a surgical emergency. Surgical therapy with ligation of the brachiocephalic trunk can be considered as the first choice of treatment to control massive and life-threatening haemorrhage.METHODSWe describe 3 cases of TAF in patients who had long-term placement of a tracheostomy tube and the occurrence of a severe massive haemorrhage caused by an injured brachiocephalic trunk. All cases required emergent surgical revision. Different surgical techniques were used. In addition to the 3 case reports, we present a review of the literature of published TAF cases, summarize the different measures to control bleeding and compare the operative procedures used in the treatment of TAF.RESULTSThe occurrence of TAF is rare and constitutes a surgical emergency. The mortality rate of tracheoarterial erosion is 100% without surgical intervention for active bleeding into the airway. Therefore, rapid control of bleeding (via digital compression and an overinflated cuff) is the most important and first step of therapy. Subsequent emergency surgery with ligation and resection of the TAF and covering of the trachea should be considered to finally control the massive haemorrhage. In addition, cardiopulmonary bypass and circulatory arrest can be useful for surgical treatment of cases with uncontrollable bleeding.CONCLUSIONSThe mortality rate after resection of the fistula remains high. Finally, the most important factors for patient survival and outcomes are quick diagnosis of the TAF and immediate surgical control of bleeding.
      PubDate: Mon, 31 Jul 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx249
  • Results of treatment for thymic neuroendocrine tumours: multicentre
           clinicopathological study†
    • Authors: Ose N; Maeda H, Inoue M, et al.
      First page: 18
      Abstract: AbstractOBJECTIVESA thymic neuroendocrine tumour (TNET) is rare, and few comprehensive reports of treatment results have been presented. To clarify the clinicopathological characteristics of TNET in affected patients, outcomes were retrospectively examined using cases accumulated in a multicentre survey.METHODSThirty patients (25 men and 5 women) who underwent surgical resection or biopsy procedures at 10 institutions of the Thoracic Surgery Study Group of Osaka University (TSSGO) between January 1986 and June 2015 and pathologically diagnosed with TNET were enrolled.RESULTSThe examined tumours were classified as typical carcinoid in 7 patients, atypical carcinoid in 11 patients, large-cell neuroendocrine carcinoma in 3 patients and small-cell carcinoma in 9 patients, of which 2 underwent surgical biopsy procedures and 28 surgical resection, with a macroscopic complete resection procedure performed in 27 patients. Induction therapy was performed in 2 patients and adjuvant therapy in 10 patients. Thirteen patients had recurrence, with distant metastasis, especially in bone and lung tissues, more frequent than local recurrence. Overall survival was 77% after 5 years and 35% after 10 years, whereas relapse-free survival was 48% and 29%, and cancer-specific survival was 90% and 48%, respectively. Overall survival was significantly better in patients who underwent macroscopic complete resection (P = 0.010). As for relapse-free survival patients, TNM Stage I or II (P = 0.011) and received adjuvant therapy patients (P = 0.042) showed good survival rates.CONCLUSIONSThe prognosis of patients with TNET was favourable in those treated with macroscopic complete resection. Survival is promising even in patients with postoperative recurrence, following treatment utilized for pulmonary neuroendocrine tumour or gastroenteropancreatic neuroendocrine tumour.
      PubDate: Thu, 17 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx265
  • Degree of pulmonary fissure completeness can predict postoperative
           cardiopulmonary complications and length of hospital stay in patients
           undergoing video-assisted thoracoscopic lobectomy for early-stage lung
    • Authors: Li S; Zhou K, Wang M, et al.
      First page: 25
      Abstract: AbstractOBJECTIVESTo estimate the effects of pulmonary fissure completeness on postoperative cardiopulmonary complications (PCCs) and hospital stay in patients undergoing video-assisted thoracoscopic surgery lobectomy for early-stage non-small-cell lung cancer.METHODSWe performed a single-centre retrospective analysis based on the prospectively maintained data of our institution during the study period. Demographic differences between the PCC group and the non-PCC group were initially examined. Then, the patients were classified into 3 groups according to their fissure sum averages (FSAs: 0 ≤ FSA ≤ 1, 1 < FSA ≤ 2, 2 < FSA ≤ 3) calculated by fissure development scores. The differences in PCC incidences and hospital stay between these 3 groups were further evaluated. Finally, FSA > 1 was determined as the cut-off to indicate the degree of pulmonary fissure completeness and involved into a multivariate logistic regression model to identify the predictors for PCCs.RESULTSIn total, 528 patients with Stage I to Stage II non-small-cell lung cancer were enrolled. There were 343 patients with 0 ≤ FSA ≤ 1, 105 patients with 1 < FSA ≤ 2 and 80 patients with 2 < FSA ≤ 3. Pulmonary complication rate in patients with 1 < FSA ≤ 2 (25.7% vs 14.3%; P = 0.006) and with 2 < FSA ≤ 3 (33.8% vs 14.3%; P < 0.001) was significantly higher than that in patients with 0 ≤ FSA ≤ 1. No difference was found in cardiovascular complication rate between these groups (P = 0.22). The Kaplan–Meier analysis showed that the length of hospital stay and the length of chest tube drainage in patients with 1 < FSA ≤ 2 and with 2 < FSA ≤ 3 were significantly longer than those in patients with 0 ≤ FSA ≤ 1. Incomplete pulmonary fissure (FSA > 1) was a strong independent predictor for PCCs (odds ratio = 2.12; P = 0.002) in the multivariate analysis.CONCLUSIONSThe degree of pulmonary fissure completeness can predict the PCCs and the length of hospital stay following video-assisted thoracoscopic surgery lobectomy for early-stage non-small-cell lung cancer.
      PubDate: Fri, 11 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx261
  • Mortality and morbidity of patients on the waiting list for coronary
           artery bypass graft surgery
    • Authors: da Fonseca V; De Lorenzo A, Tura B, et al.
      First page: 34
      Abstract: AbstractOBJECTIVESThe public health care system in Brazil has extensive waiting lists of patients requiring complex operations such as coronary artery bypass grafting (CABG). The purpose of this study was to identify the mortality and morbidity rates of the patients awaiting CABG and identify predictors of adverse events and their association with perioperative outcomes.METHODSWe conducted a retrospective analysis of outpatient medical records of patients referred for this elective procedure in Rio de Janeiro, Brazil. Excluded from the study were records of patients with any of the following: an indication for urgent surgery, unstable angina or concomitant surgical valvular disease or subsequent transfer to clinical or percutaneous therapy.RESULTSA total of 274 patients were identified and met the inclusion criteria, with a median waiting time for an operation of 142.7 days. While waiting for CABG surgery, 31 (11.3%) patients died of any cause and 42 (15.3%) patients had a serious cardiac event (death, myocardial infarction or unstable angina). Of the 22 (8%) incidents of acute myocardial infarction, 8 (2.9%) were non-fatal and 14 (5.1%) were fatal. There was a greater risk of death awaiting CABG surgery in patients with a left ventricular ejection fraction below 45% (hazard ratio = 2.33, 95% confidence interval 1.02–5.32; P = 0.039). The operative mortality rate was 5.8%. Although there was no evidence of worse perioperative outcomes in patients with prolonged waiting times for an operation, there was an association between waiting more than 16 weeks for an operation and death while on the list.CONCLUSIONSExtensive waiting periods for CABG contribute to higher mortality and morbidity rates, especially in patients with left ventricular dysfunction.
      PubDate: Thu, 24 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx276
  • Surgical treatment of postinfarction ventricular septal defect: risk
           factors and outcome analysis
    • Authors: Pojar M; Harrer J, Omran N, et al.
      First page: 41
      Abstract: AbstractOBJECTIVESPostinfarction ventricular septal defect is a serious mechanical complication of acute myocardial infarction associated with high postoperative mortality. The aim of this study was to review our experience with surgical repair of postinfarction ventricular septal defect and to identify predictors of early and late outcomes.METHODSThirty-nine patients (19 men and 20 women, mean age 68.4 ± 9.9 years) with postinfarction ventricular septal defect who underwent surgical repair at our institution between 1996 and 2016 were retrospectively evaluated. Risk factors were assessed by univariate analysis, with those found significant included in multivariate analysis.RESULTSThe ventricular septal defect was anterior in 21 (54%) patients and posterior in 18 (46%) patients. Mean aortic cross-clamp time was 91.8 ± 26.8 min, and mean cardiopulmonary bypass time was 146.3 ± 49.7 min. Twelve (31%) patients underwent concomitant coronary artery bypass grafting. The 30-day mortality rate was 36% (n = 14). The 30-day survival rate was higher with than without concomitant coronary artery bypass grafting (83% vs 56%), but concomitant coronary artery bypass grafting did not influence late survival (P = 0.098). Univariate analysis identified age, emergency surgery, inotropic support, Killip class, preoperative aspartate aminotransferase concentration, renal replacement therapy and ventricular septal defect diagnosis to operation interval as predictors of 30-day mortality. However, multivariate analysis showed that age and renal replacement therapy were the only independent risk factors of 30-day mortality.CONCLUSIONSSurgical repair of postinfarction ventricular septal defect has a high 30-day mortality rate. Higher age at presentation and postoperative renal replacement therapy are independent predictors of early mortality.
      PubDate: Thu, 24 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx230
  • Risk of de novo dialysis after elective cardiac surgery according to
           preoperative renal dysfunction
    • Authors: Borracci R; Rubio M, Baldi J, et al.
      First page: 47
      Abstract: AbstractOBJECTIVESThe aim was to estimate the risk of dialysis postoperative de novo dialysis in patients undergoing elective cardiac surgery, according to varying degrees of pre-existing renal dysfunction, and to compare the outcomes with the expected prevalence of dialysis based on several risk scores.METHODSA retrospective analysis was performed over a 5-year period (2012–16) from a series of 1332 adult patients who underwent elective cardiac surgery. Patients were divided into 3 estimated creatinine clearance (eCrCl) groups: eCrCl >60 ml/min, eCrCl from 50 ml/min to 60 ml/min and eCrCl ≤49 ml/min. The primary outcome was any renal failure requiring first-time dialysis during the postoperative hospital stay. The expected risk for postoperative dialysis was calculated with 3 predictive scores: the Society of Thoracic Surgeons Bedside Risk Tool, the Cleveland Clinic Score and the Simplified Renal Index. The global accuracy of eCrCl and the different scores was evaluated in terms of calibration and discrimination.RESULTSIn the overall population, 26.6% of patients presented moderate or severe pre-existing renal dysfunction, and the need for de novo dialysis varied from 0.6% to 5.0% depending on the degree of preoperative eCrCl (P < 0.0001). Preoperative renal dysfunction with eCrCl <50 ml/min was associated with nearly 8-fold increase of risk for postoperative dialysis; eCrCl between 50 ml/min and 60 ml/min showed a 2-fold increase, though this last difference did not reach statistical significance.CONCLUSIONSIn elective cardiac surgery, isolated preoperative eCrCl seemed to be an accurate indicator of risk for postoperative de novo dialysis. More complex models did not provide additional information to stratify that risk.
      PubDate: Wed, 16 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx271
  • Triangular resection versus neochordal replacement for posterior leaflet
           prolapse: a morphological assessment
    • Authors: Ma W; Chen J, Zhang W, et al.
      First page: 54
      Abstract: AbstractOBJECTIVESTo evaluate the morphological reconstruction as assessed by 3D transoesophageal echocardiography after triangular resection and neochordal replacement in the treatment of posterior leaflet prolapse.METHODSWe retrospectively selected 46 patients with isolated posterior leaflet prolapse who were undergoing mitral valve repair using triangular resection (n = 20) and neochordal replacement (n = 26) techniques. Sixty patients without valvular heart disease were also included as the control group. Thorough 3D transoesophageal echocardiography inspections were performed for the entire cohort, and morphological parameters of mitral valve complex were measured and compared. Mid-term repair durability was followed up by transthoracic echocardiography.RESULTSThe baseline parameters, including annular size, leaflet tenting, leaflet area, coaptation line lengths and aortomitral angle, were significantly larger in prolapsed valves. After repair, tenting volume, exposed posterior leaflet area and coaptation line lengths were restored to the normal range. Baseline clinical characteristics and 3D transoesophageal echocardiography parameters were comparable in patients treated with 2 techniques, and all parameters remained comparable between the resection and the non-resection groups after repair, except for exposed posterior leaflet area and posterior leaflet ratio. At 62.2 ± 18.5 months after surgery, degrees of residual regurgitation were similar between 2 techniques.CONCLUSIONSTriangular resection and neochordal replacement can achieve comparable restoration to structural normality and functional competency of mitral valves with posterior leaflet prolapse. Resection of prolapsed segment does not significantly affect coaptation geometry but instead may aid in achieving normal posterior leaflet ratio.
      PubDate: Mon, 14 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx260
  • Anticoagulation management following left ventricular assist device
           implantation is similar across all provider strategies†
    • Authors: McDavid A; MacBrair K, Emani S, et al.
      First page: 60
      Abstract: AbstractOBJECTIVESThromboembolic and bleeding events are potential complications following left ventricular assist device implantation. A tight control of the international normalized ratio (INR) is believed to be crucial in the reduction of postimplant complications. There is significant variability among institutions as to whether a device implanting centre should be managing the INR. In this study, we evaluated the effect of INR management strategies in maintaining a therapeutic INR.METHODSA retrospective review was utilized to identify patients implanted with either the HeartMate II or the HeartWare HVAD between January 2011 and February 2016. Patients were stratified into 4 groups based on the post-discharge INR management strategy: outside hospital system anticoagulation clinic, outside hospital primary care provider, implanting centre anticoagulation clinic or implanting centre ventricular assist device office. The INR data were collected and analysed for both the early (discharge, 7, 14, 21 and 30 days) and late (3, 6, 9 and 12 months) postoperative periods.RESULTSThere were 163 patients identified during the study period who met the study inclusion criteria: 49 (30%) patients were managed by an outside hospital system anticoagulation clinic, 59 (36.2%) patients by an outside hospital physician/primary care provider, 22 (13.5%) patients by the implanting centre anticoagulation clinic and 33 (20.2%) patients by the implanting centre ventricular assist device office. There were no statistically significant differences found between management strategies across all time points.CONCLUSIONSThere was no statistically significant difference found between the management strategies examined. Regardless of the chosen INR management strategy, patients have similar INR values and postoperative outcomes.
      PubDate: Mon, 14 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx255
  • Endothelin-1 is associated with dilatation of the left atrium and can be
           an independent predictor of atrial fibrillation after mitral valve surgery
    • Authors: Lu R; Ma N, Jiang Z, et al.
      First page: 66
      Abstract: AbstractOBJECTIVESThis study analysed the association between endothelin-1 (ET-1) and left atrial dimension (LAD) and evaluated whether ET-1 can be a predictor of postoperative atrial fibrillation (POAF) after mitral valve surgery. METHODSThis is a prospective study that enrolled 80 patients who underwent isolated mitral valve surgery. Plasma concentrations of ET-1 from peripheral venous blood were tested. POAF was detected using a telemetry strip or 12-lead electrocardiogram until the time of discharge.RESULTSPatients undergoing mitral valve surgery with preoperative sinus rhythm (n = 80; average age 63.9 ± 7.9 years) were recruited to this study. POAF was documented in 31 (38.8%) patients. Preoperative plasma ET-1 levels were higher in patients with POAF compared to those without POAF (2.23 ± 0.67 vs 1.68 ± 0.59 pg/ml; P < 0.001). The plasma concentrations of ET-1 were positively correlated with LAD (Pearson’s r = 0.421; P < 0.001). Multivariate logistic regression analysis revealed that LAD (odds ratio 1.170, 95% confidence interval 1.039–1.317; P = 0.009) and preoperative plasma ET-1 levels (upper versus lower 50th percentile: odds ratio 3.713, 95% confidence interval 1.085–12.701; P = 0.037) were predictors of POAF after mitral valve surgery.CONCLUSIONSPlasma levels of ET-1 were positively correlated with LAD in patients with mitral valve disease. An elevated preoperative plasma ET-1 level can be used as a predictor of POAF after mitral valve surgery.
      PubDate: Mon, 14 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx250
  • 3D printed mitral valve models: affordable simulation for robotic mitral
           valve repair
    • Authors: Premyodhin N; Mandair D, Ferng A, et al.
      First page: 71
      Abstract: AbstractOBJECTIVES3D printed mitral valve (MV) models that capture the suture response of real tissue may be utilized as surgical training tools. Leveraging clinical imaging modalities, 3D computerized modelling and 3D printing technology to produce affordable models complements currently available virtual simulators and paves the way for patient- and pathology-specific preoperative rehearsal.METHODSWe used polyvinyl alcohol, a dissolvable thermoplastic, to 3D print moulds that were casted with liquid platinum-cure silicone yielding flexible, low-cost MV models capable of simulating valvular tissue. Silicone-moulded MV models were fabricated for 2 morphologies: the normal MV and the P2 flail. The moulded valves were plication and suture tested in a laparoscopic trainer box with a da Vinci Si robotic surgical system. One cardiothoracic surgery fellow and 1 attending surgeon qualitatively evaluated the ability of the valves to recapitulate tissue feel through surveys utilizing the 5-point Likert-type scale to grade impressions of the valves.RESULTSValves produced with the moulding and casting method maintained anatomical dimensions within 3% of directly 3D printed acrylonitrile butadiene styrene controls for both morphologies. Likert-type scale mean scores corresponded with a realistic material response to sutures (5.0/5), tensile strength that is similar to real MV tissue (5.0/5) and anatomical appearance resembling real MVs (5.0/5), indicating that evaluators ‘agreed’ that these aspects of the model were appropriate for training. Evaluators ‘somewhat agreed’ that the overall model durability was appropriate for training (4.0/5) due to the mounting design. Qualitative differences in repair quality were notable between fellow and attending surgeon.CONCLUSIONS3D computer-aided design, 3D printing and fabrication techniques can be applied to fabricate affordable, high-quality educational models for technical training that are capable of differentiating proficiency levels among users.
      PubDate: Mon, 31 Jul 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx243
  • Two-staged hybrid ablation of non-paroxysmal atrial fibrillation: clinical
           outcomes and functional improvements after 1 year
    • Authors: Budera P; Osmancik P, Talavera D, et al.
      First page: 77
      Abstract: AbstractOBJECTIVESHybrid ablation of atrial fibrillation (AF) is a promising treatment strategy; however, data regarding its efficacy and safety are still limited.METHODSPatients with non-paroxysmal AF were enrolled. First, a thoracoscopic, epicardial isolation of pulmonary veins and the left atrial posterior wall (‘box lesion’) was performed; a novel unipolar/bipolar radiofrequency device was used. Moreover, in 12 patients enrolled thereafter, the left atrial appendage was occluded. Electrophysiological evaluation and catheter ablation were performed 2–3 months later, with the goal of verifying or completing (if needed) the box lesion and ablation of the ganglionated plexi and the cavotricuspid isthmus. Outcomes were assessed using 1-week and 24-h Holter monitoring, repeated echocardiography and laboratory measurements.RESULTSThirty-eight patients (13 persistent and 25 long-standing persistent AF) were enrolled with a mean AF duration of 33 ± 32.9 months. The procedure was successfully completed in 35 patients; 3 patients underwent only the surgical part because of a postoperative left atrial appendage thrombus (2 patients) and perioperative stroke (1 patient). After 6 months, 30 (86%) patients were arrhythmia-free, whereas 80% were also off antiarrhythmics. After 1 year, 28 (82%) patients were arrhythmia-free, 79% were off anti-arrhythmics and 47% were off anticoagulation treatment. Four (10.5%) serious postoperative complications occurred, including 1 stroke, 1 right phrenic nerve palsy and 2 pneumothoraxes with a need for drainage. Significant improvements were observed in echocardiographic, functional and serological parameters.CONCLUSIONSHybrid ablation is an effective treatment strategy for patients with persistent or long-standing persistent AF. Over 80% of patients were arrhythmia-free 1 year after the procedure. Sinus rhythm restoration was accompanied by improvements in functional, echocardiographic and serological markers.
      PubDate: Mon, 31 Jul 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx248
  • eComment. The importance of intra-procedural end-points for the long-term
           success of hybrid ablation
    • Authors: Bisleri G.
      First page: 83
      Abstract: We read with interest the manuscript by Budera et al. [1] regarding the 1-year clinical outcomes following a sequential-staged approach for hybrid ablation of non-paroxysmal atrial fibrillation. While the authors should be commended for their results, the manuscript raises several issues both in terms on electrophysiological findings and postoperative results.
      PubDate: Tue, 19 Dec 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx301
  • Acute DeBakey Type I aortic dissection without intimal tear in the arch:
           is total arch replacement the right choice'
    • Authors: Colli A; Carrozzini M, Francescato A, et al.
      First page: 84
      Abstract: AbstractOBJECTIVESSurgical management of acute DeBakey Type I aortic dissection without intimal tear in the aortic arch is controversial. This study compared short- and long-term outcomes of total arch replacement (TAR) versus limited ascending aorta/hemiarch replacement (no-TAR) in a consecutive series of patients.METHODSBetween January 1998 and December 2015, 220 consecutive patients were operated for DeBakey Type I acute aortic dissection; 135 cases did not exhibit an intimal entry tear in the aortic arch and were subsequently selected to comprise the primary study cohort. A secondary subgroup analysis was made within these 135 cases, which comprised patients who received antegrade cerebral perfusion as the neuroprotective strategy of choice (n = 45).RESULTSMean follow-up period was 5 ± 4 years. Among the patients selected, 21 (16%) underwent TAR. Thirty-day mortality was higher in the TAR group (38% vs 21%, P = 0.04). Postoperative complication rates were similar between the groups (61% vs 73%, P = 0.31). Long-term mortality and late aortic reintervention rates were also similar (7% vs 30%, P = 0.36 and 27% vs 14%, P = 0.32, respectively). From the subgroup of patients with antegrade cerebral perfusion, 14 (31%) underwent TAR and 31 (69%) had no-TAR. Mean follow-up-time was 3 ± 2 years. Thirty-day mortality was higher in the TAR group (50% vs 16%, P < 0.01), postoperative complications, long-term mortality and late aortic reintervention rates were similar (64% vs 69%, P = 0.73; 0% vs 19%, P = 0.22; 29% vs 8%, P = 0.17, respectively).CONCLUSIONSTAR was associated with higher 30-day mortality compared with the less extensive hemiarch replacement. In the long term, TAR showed a trend of improved survival and higher reintervention rate.
      PubDate: Mon, 31 Jul 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx229
  • A novel method for prevention of stent graft-induced distal re-dissection
    • Authors: Masada K; Shimamura K, Sakamoto T, et al.
      First page: 91
      Abstract: AbstractOBJECTIVESStent graft-induced distal re-dissection (SIDR) is a burdensome complication after thoracic endovascular aortic repair (TEVAR) for Type B aortic dissection. We developed a novel method to prevent SIDR by placing a small-diameter short stent graft [Excluder Aortic Extender (Cuff)] at the distal landing zone (DLZ) and reviewed its effectiveness in this study.METHODSNinety patients who underwent TEVAR for Type B aortic dissection using commercially available devices between January 2008 and September 2016 were retrospectively reviewed. Among them, TEVAR with the Cuff technique was performed in 36 (40%) cases, in which a Cuff was placed at the DLZ in the descending aorta prior to the main stent graft deployment to avoid excessive stent graft oversizing at the distal end. The effectiveness of the Cuff technique was assessed by evaluating mid-term clinical results, including the incidence of SIDR.RESULTSTechnical success was achieved in all 90 cases. During a median follow-up time of 40.4 months (range 0.2–90.6 months), 8 SIDRs were documented using multidetector computed tomography images. Freedom from SIDR was significantly lower in the Cuff group (Cuff: 100%/5 years vs non-Cuff: 84.6%/5 years; P = 0.04), whereas no difference was observed between both groups in the oversizing rate at the DLZ (19.9 ± 8.5% vs 17.8 ± 9.9%; P = 0.29).CONCLUSIONSPlacement of a small-diameter short stent graft at the DLZ (Cuff technique) in TEVAR for aortic dissection is an easy procedure that may reduce the incidence of SIDR.
      PubDate: Mon, 31 Jul 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx245
  • Influence of staged repair and primary repair on outcomes in patients with
           complete atrioventricular septal defect and tetralogy of Fallot: a
           systematic review and meta-analysis
    • Authors: Lenko E; Kulyabin Y, Zubritskiy A, et al.
      First page: 98
      Abstract: AbstractOBJECTIVESComplete atrioventricular septal defect with tetralogy of Fallot is a rare congenital heart disease. The combination of these lesions occurs in about 1% of all patients with atrioventricular canal defects and in 5–6% of patients with tetralogy of Fallot. To assess the influence of surgical strategy on the survival and reintervention rate for the left atrioventricular valve and right ventricular outflow tract.METHODSWe analyzed all related studies since 1986. Thirty-eight articles were initially retrieved via PubMed/MEDLINE, Cochrane Central Register of Controlled Trials and Google Scholar, from which 18 retrospective studies were included in the systematic review and 8 studies in the meta-analysis.RESULTSThere was no significant difference in the 6-year survival between staged repair and primary repair [80 patients in the primary group and 81 patients in the staged group; I2 = 0%; time-to-event data Peto odds ratio 0.66, 95% confidence interval (CI) 0.3-1.5, P = 0.31; hazard ratio 0.66, 95% CI 0.3–1.3, P = 0.23]. Both groups had an equal reintervention rate for the left atrioventricular valve [75 patients in the primary group and 71 patients in the staged group; I2 = 0.26%; the Mantel-Haenszel odds ratio 0.60, 95% CI 0.22–1.68, P = 0.33], but patients who received an initial palliation had a higher rate of reoperation on the right ventricular outflow tract [I2 = 0%; the Mantel-Haenszel odds ratio 0.27, 95% CI 0.27–0.9988, P = 0.05].CONCLUSIONSResults of this meta-analysis reveal no difference in 6-year survival and reoperation rate for the left atrioventricular valve; however, patients who underwent staged repair had a higher rate of reintervention for the right ventricular outflow tract, which could be related to initially poor pulmonary bed anatomy. Therefore, both the primary repair and the staged repair are acceptable options for repair of complete atrioventricular septal defect with tetralogy of Fallot. The choice of surgical strategy must consider the anatomy of the pulmonary bed, patient condition and associated anomalies, which could affect surgical risk.
      PubDate: Fri, 25 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx267
  • Does mitral valve repair matter in infants with ventricular septal defect
           combined with mitral regurgitation'
    • Authors: Kulyabin Y; Soynov I, Zubritskiy A, et al.
      First page: 106
      Abstract: AbstractOBJECTIVESThis study aimed to assess mitral valve function after repair of ventricular septal defect (VSD) combined with mitral regurgitation (MR) in the mid-term follow-up period, to evaluate the clinical utility of simultaneous mitral valve repair (MVR).METHODSFrom June 2005 to March 2014, 60 patients with VSD and MR underwent surgical treatment. After performing propensity score analysis (1:1) for the entire sample, 46 patients were selected and divided into 2 groups: those with VSD closure and MVR (VSD + MVR, 23 patients) and those with VSD closure without mitral valve intervention (VSD only, 23 patients). The follow-up period ranged from 12 to 48 months (median 32 months; interquartile range 28–40 months).RESULTSThere was no postoperative mortality in either group. There was no significant difference in the duration of the postoperative period between groups (ventilation time, P = 0.49; inotropic support, P = 0.50). Mean cardiopulmonary bypass time and aortic cross-clamping time were significantly longer in the ‘VSD + MVR’ group (cardiopulmonary bypass, P = 0.023; aortic cross-clamp, P < 0.001). There was no significant difference in regurgitation area (P = 0.30) and MR grade (P = 0.76) between groups postoperatively. There was no significant difference in freedom from MR ≥ 2+ between groups (log-rank test, P = 0.28). In the ‘VSD + MVR’ group, 12-, 36- and 42-month freedom from MR ≥ 2+ values were 100%, 59 ± 10.4% [95% confidence interval (CI) 36.1–76.2%] and 44 ± 15% (95% CI 15.8–69.7%), respectively, while in the ‘VSD only’ group, these values were 100%, 54.5 ± 10.6% (95% CI 32–72.3%) and 54.5 ± 10.6% (95% CI 30–72.3%), respectively. The only significant risk factor for recurrent MR ≥ 2+ during the follow-up period was mild residual MR in the early postoperative period (P = 0.037).CONCLUSIONSIn infants with VSD combined with MR, simultaneous MVR has no benefits simultaneous MVR provided no advantage over that of isolated VSD closure. We found that the presence of mild residual MR in the early postoperative period predisposes the development of MR ≥ 2+ in follow-up period.
      PubDate: Mon, 14 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx231
  • Controlled flow diversion in hybrid venoarterial–venous
           extracorporeal membrane oxygenation
    • Authors: Cakici M; Gumus F, Ozcinar E, et al.
      First page: 112
      Abstract: AbstractOBJECTIVESPatients on venoarterial or venovenous extracorporeal membrane oxygenation (ECMO) support may require venoarterial–venous (VAV-ECMO) configuration during follow-up. We report 12 cases of VAV-ECMO with significant outflow steal.METHODSBetween October 2014 and November 2016, a total of 97 patients (56.6 ± 12.0 years; 59 men/38 women; body surface area 1.84 ± 0.36 m2) were supported with venoarterial ECMO (n = 85) or venovenous ECMO (n = 12). Among the 97 patients, 12 patients (age 61.5 ± 3.5 years; 8 men/4 women; body surface area 1.8 ± 0.8 m2) required hybrid use of VAV-ECMO. Control and monitoring of flow ratios in supplying cannulae using flow sensors were performed, and occluder devices were used according to patient requirements to achieve optimum haemodynamics and oxygenation.RESULTSAmong the 85 venoarterial ECMO-supported patients, Harlequin syndrome was detected in 9 cases (10.6%) who required switching to VAV-ECMO. Among the 12 patients, 3 (25%) patients required VAV-ECMO while on venovenous ECMO support as a result of initial respiratory failure subsequently developed cardiac decompensation. Mean duration of VAV-ECMO support was 6.4 ± 1.8 days. Overall, on VAV-ECMO support, 70.0 ± 4.6% of blood flow was detected within the supplying right internal jugular vein cannula as a result of lower afterload in venous system. We partially occluded the internal jugular vein cannula and directed flow to the common femoral artery. After adjustment, 34.3 ± 7.4% flow was directed to internal jugular vein and 65.6 ± 7.4% to common femoral artery.CONCLUSIONSNon-invasive monitoring of flow rates within the supplying cannulae of VAV-ECMO and the use of partial occlusion for venous-supplying cannula enable individualized patient management and effective weaning from VAV-ECMO.
      PubDate: Wed, 16 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx259
  • Rotational speed modulation used with continuous-flow left ventricular
           assist device provides good pulsatility†
    • Authors: Naito N; Nishimura T, Iizuka K, et al.
      First page: 119
      Abstract: AbstractOBJECTIVESContinuous-flow left ventricular assist devices (CF-LVADs) are widely used to treat patients with end-stage heart failure. Although continuous flow is different from physiological flow, patients show improved outcomes after CF-LVAD implantation. A novel rotational speed (RS) modulation system used with CF-LVAD (EVAHEART) has been developed, which can change RS in synchronization with the native cardiac cycle. We conducted the present study to investigate the influence of the system on pulsatility in peripheral perfusion.METHODSWe implanted EVAHEART devices at the left ventricular apex drainage and the descending aortic perfusion via a left thoracotomy in 7 adult goats (56.8 ± 8.1 kg). Cardiogenic shock was induced by a beta-adrenergic antagonist. We evaluated the pulsatility index and maximal time derivative of flow rate (max dQ/dt) of the carotid, mesenteric and renal arteries. These data were collected with a bypass rate of 100% under 4 conditions: circuit clamp, continuous mode, co-pulse mode (increased RS during systole) and counter-pulse mode (increased RS during diastole).RESULTSThe pulsatility indexes of the carotid and renal artery in the co-pulse mode were significantly higher than in the other modes. Max dQ/dt of the carotid and mesenteric arteries were significantly higher in the co-pulse mode than in the counter-pulse mode.CONCLUSIONSThe co-pulse mode of this novel RS modulation system may provide better pulsatility not only in the large vessels but also in the peripheral vasculature.
      PubDate: Thu, 10 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx236
  • Cold-inducible ribonucleic acid-binding protein attenuates acute kidney
           injuries after deep hypothermic circulatory arrest in rats
    • Authors: Yu L; Gu T, Liu Y, et al.
      First page: 124
      Abstract: AbstractOBJECTIVESCold-inducible ribonucleic acid-binding protein (CIRP) has been identified to play a role in the antiapoptotic effect of hypothermia. We sought to investigate the renoprotection of CIRP in a rat model of deep hypothermic circulatory arrest.METHODSOverexpression and knockdown of CIRP were achieved in vivo by directly injecting lentivirus vectors containing packaging lentivirus (pL)/internal ribosome entry site (IRES)/green fluorescent protein (GFP)-CIRP or pL/short hairpin RNA (shRNA)/F-cold inducible RNA binding protein (F-CIRP)-A into the renal parenchyma of rats 7 days before deep hypothermic circulatory arrest under the ultrasound guidance. The vehicles or control lentivirus vectors were given to the control group or the control vector group, respectively. Renal function and apoptosis activity were evaluated by serum cystatin C, serum/tissue neutrophil gelatinase-associated lipocalin and terminal deoxynucleotidyl transferase 2ʹ-deoxyuridine, 5ʹ-triphosphate nick-end labelling assay at 24 h after surgery. The expression of CIRP messenger RNA (mRNA) was assessed by quantitative real-time polymerase chain reaction. Protein expression of CIRP and caspase 3 was tested by Western blot.RESULTSCompared with the sham group, rats in the control group showed increased expression of CIRP mRNA, CIRP protein, caspase 3 and the apoptotic rate (P < 0.01). However, when compared with the control group, rats in the pL/IRES/GFP-CIRP group showed significantly decreased caspase 3 and apoptosis activities while further increased expression of CIRP mRNA and protein. Rats in the pL/shRNA/F-CIRP-A group showed increased caspase 3 and apoptosis activities and further decreased expression of CIRP mRNA and protein (P < 0.01), when compared with the control group. Renal function was markedly protected in the pL/IRES/GFP-CIRP group and impaired in the pL/shRNA/F-CIRP-A group.CONCLUSIONSOur findings suggest that the CIRP exerts a robust renoprotective effect by inhibiting apoptosis in the rat model of deep hypothermic circulatory arrest.
      PubDate: Mon, 14 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx262
  • Transapical cardioscopic mitral annuloplasty: a short-term survival study
           in a porcine model
    • Authors: Vu T; Oo M, Nguyen D, et al.
      First page: 131
      Abstract: AbstractOBJECTIVESThe transapical approach provides concurrent surgical access to the mitral and the aortic valves, the root of the aorta and the left atrium. We previously showed the feasibility of transapical cardioscopic (TAC) surgery in a non-survival porcine model. However, reproducibility and feasibility of ring implantation using TAC have not been reported. Therefore, in this study, we hypothesized that implantation of a mitral annuloplasty ring can be feasibly and safely carried out endoscopically via the apex of the heart.METHODSUsing a porcine model in a short-term survival study, TAC mitral annuloplasty was performed in 6 pigs via an incision over the xyphoid, under cardiopulmonary bypass and cardiac arrest. A mitral annuloplasty ring was implanted via the apex to a normal mitral annulus, using a customized set of instruments and techniques. Haemodynamics, echocardiography, cardiac computed tomography, ventriculography, electrocardiography and histopathology studies were used to evaluate the function of the mitral valve and the left ventricle, coronary system and conduction system in the perioperative period and 4 weeks later.RESULTSAll 6 animals survived and recovered from the TAC annuloplasty procedure. Postimplantation examination showed that the mitral valve was competent, left ventricular ejection fraction was 63 ± 4%, left ventricular length was 6.2 ± 0.5 cm and left ventricular end-diastolic volume was 80 ± 10 ml, which were comparable to preoperative values. Apart from a dense scar at the apex, no significant injury was noticed on the ventricle, the chordae and the mitral leaflets. The bypass, cross-clamp and implantation times were 181 ± 55 min, 130 ± 37 min and 47 ± 6 min, respectively.CONCLUSIONSDespite long surgical times due to the initial learning curve, successful execution of mitral ring annuloplasty could be safely achieved using the TAC approach, via a small incision without the involvement of sternum or the right pleural cavity, thereby potentially expanding the indication to patients with high-risk full sternotomy or right thoracotomy.
      PubDate: Wed, 30 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx282
  • Improving myocardial fractional flow reserve in coronary atherosclerosis
           via CX37 gene silence: a preclinical validation study in pigs
    • Authors: Guo S; Yang Y, Yang Z, et al.
      First page: 139
      Abstract: AbstractOBJECTIVESThe purpose of this study was to evaluate the effect of CX37 gene silence on myocardial fractional flow reserve (FFR).METHODSA total of 90 male pigs were randomly divided into saline, mock and 3 different doses (5, 10 and 20 µl) of CX37 viral suspension groups that could induce coronary plaque formation with high-fat diet. After performing myocardial FFR by intravascular ultrasound, different doses of CX37 viral suspension, saline and mock small interfering RNA (siRNA) were transfected into the related coronary. The FFR, the myocardial enzymes and the cardiac structures and functions of the pigs were detected at baseline, 4th, 8th and 12th week after transfection, respectively.RESULTSRepeated measures analysis of variance comparison showed that the difference in the FFR among the 5 groups was statistically significant (F = 27.0, P < 0.01). Post hoc analysis showed that FFR were highest in the siRNA CX37 group (20 µl), followed by the siRNA CX37 group (10 µl) and the siRNA CX37 group (5 µl), and lowest in the mock and saline groups. Left ventricular end-diastolic diameter was significantly smaller and ejection fraction was obviously higher in the 3 siRNA CX37 groups compared with the untreated groups.CONCLUSIONSOur study showed that FFR levels increased along with decreased doses of siRNA CX37 lentivirus, indicating that siRNA CX37 lentivirus may reduce the risk of coronary atherosclerosis and provide a potential approach to treat coronary heart disease.
      PubDate: Mon, 31 Jul 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx218
  • Unlocking the secrets to regenerating cardiac tissue: an update
    • Authors: Kislitsina O; Revishvili A, Cox J.
      First page: 146
      Abstract: AbstractThe use of extracellular matrix has evolved into a promising therapeutic approach for the treatment of valve disease and heart failure. Both biomechanical and biochemical signals for tissue remodelling require the presence of the extracellular matrix to recognize the remodelling signals and transfer them to the host stem cells. The extracellular matrix is the key to delivering these signals to the immigrated stem cells, and it also serves as a ‘stem cell scaffold’ making the possibility of regenerating new cardiac tissue a reality.
      PubDate: Thu, 24 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx264
  • eComment. Platelet-rich plasma and cardiac tissue regeneration
    • Authors: Spartalis M; Tzatzaki E, Athanasiou A, et al.
      First page: 154
      Abstract: We read with great interest the article by Kislitsina et al [1] titled “Unlocking the secrets to regenerating cardiac tissue: an update”. The authors present an article that is focused on cardiac tissue regeneration, a research field which has attracted considerable interest over the past years. The authors conclude that extracellular matrix (ECM) is the only promising new therapeutic approach to regenerate cardiac tissue [1]. However, is this the whole picture'
      PubDate: Tue, 19 Dec 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx321
  • Isolated transfusion of leucocyte-depleted apheresis platelet concentrates
           and outcomes after cardiac surgery
    • Authors: Koster A; Zittermann A, Birschmann I, et al.
      First page: 155
      Abstract: AbstractWe investigated the association of isolated leucocyte-depleted single-donor apheresis platelet concentrate transfusion with short- and long-term outcomes of patients undergoing isolated or combined coronary artery bypass and valve surgery. Propensity score matching was used to compare the results of patients without blood product transfusion and patients with isolated platelet transfusion (n = 167 per group). The primary end-point was a composite of operative complications. Additionally, we assessed coronary reintervention and overall mortality over a follow-up period of 7.5 years. In the platelet− and platelet+ groups, the composite end-point was reached at 9.6% and 12.3%, respectively (P = 0.307). None of the patients died within 30 days. None of the patients needed coronary reintervention during follow-up. Long-term mortality was similar between groups (P > 0.05). Isolated leucocyte-depleted apheresis platelet transfusion does not appear to be associated with an increase in morbidity or mortality in non-complex cardiac surgery. However, larger studies are needed.
      PubDate: Wed, 16 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx253
  • Implantable epicardial cardioverter–defibrillator-induced localized
           constrictive pericarditis
    • Authors: Mizuno T; Goya M, Hirao K, et al.
      First page: 158
      Abstract: AbstractIn the 1990s, epicardial implantable cardioverter–defibrillator (ICD) patches were frequently implanted to treat life-threatening ventricular arrhythmia. However, owing to the high rates of functional failure, the patch system has been replaced by transvenous ICD leads system. Although morphological abnormalities such as dense fibrosis around the patch are quite frequent, epicardial ICD patch-induced localized constrictive pericarditis is very rare. We encountered a patient who had severe heart failure due to constrictive pericarditis, 23 years after the implantation of epicardial ICD patches. The heart failure was treated after complete resection of the patches and dense fibrosis on the surface of both the right and the left ventricles. To our knowledge, this is the first report on the treatment of epicardial ICD patch-induced localized constrictive pericarditis.
      PubDate: Mon, 07 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx183
  • A novel approach to treating a post-sternotomy internal mammary artery
    • Authors: Al-Radhi Y; Shrivastava V.
      First page: 161
      Abstract: AbstractPseudoaneurysms of the internal mammary artery are a rare complication of median sternotomy. They may clinically present as a pulsatile mass or with signs of rupture and haemodynamic instability. In stable patients, percutaneous thrombin injection of the pseudoaneurysm is a safe and minimally invasive procedure to treat the pseudoaneurysm and avoid further surgery. We present a case of a pseudoaneurysm of a branch of the right internal mammary artery post-median sternotomy with no signs or symptoms of haemodynamic instability. The pseudoaneurysm was successfully treated with ultrasound-guided percutaneous thrombin injection.
      PubDate: Thu, 10 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx254
  • Hybrid treatment combining robotic coronary artery bypass grafting and
           percutaneous catheter radiofrequency ablation
    • Authors: Tarui T; Ishikawa N, Kiuchi R, et al.
      First page: 163
      Abstract: AbstractIsolated coronary artery bypass grafting associated with atrial fibrillation is routinely performed through a sternotomy, and cardiac arrest. Advancements in this surgical approach have led to better cosmesis, a quick postoperative recovery, with the same postoperative results. We report a case of a novel, less invasive hybrid treatment combining robot-assisted coronary artery bypass grafting and percutaneous radiofrequency catheter ablation.
      PubDate: Thu, 31 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx291
  • A unique variation with five branches of the aortic arch
    • Authors: Ma Z; Han J, Li H, et al.
      First page: 165
      Abstract: AbstractHere, we present a unique case with 5 branches of the aortic arch (AA), namely the right common carotid artery, left common carotid artery, left thyrocervical trunk, left subclavian artery and right subclavian artery (RSA), from right to left. We found that the left thyrocervical trunk originated directly from the AA rather than the left subclavian artery. In addition, the RSA arose dorsally as the last branch of the AA and passed posteriorly to the oesophagus to supply the right upper limb. In addition, the right vertebral artery originated from the right common carotid artery instead of the RSA. Despite numerous studies on AA variations, to our knowledge, this is the first case of the left thyrocervical trunk originating directly from the AA and the RSA arising dorsally as the last branch of a 5-branch AA. Our case provides useful information to anatomists, radiologists and neck and thoracic surgeons.
      PubDate: Thu, 17 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx256
  • Management of retrograde intraoperative Type A aortic dissection from
           descending thoracic aortic injury
    • Authors: Hornsby W; Weir W, Khaja M, et al.
      First page: 167
      Abstract: AbstractIntraoperative Type A aortic dissection during cardiothoracic surgery is extremely rare, but the consequences can be fatal. We report 2 case summaries of retrograde intraoperative Type A aortic dissection from descending thoracic aortic injury during ascending aortic cannulation and provide a discussion on management.
      PubDate: Thu, 31 Aug 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx274
  • Spotlight on recently published EJCTS articles
    • First page: 169
      PubDate: Tue, 19 Dec 2017 00:00:00 GMT
      DOI: 10.1093/icvts/ivx407
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