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Publisher: Oxford University Press   (Total: 396 journals)

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Showing 1 - 200 of 396 Journals sorted alphabetically
ACS Symposium Series     Full-text available via subscription   (SJR: 0.189, CiteScore: 0)
Acta Biochimica et Biophysica Sinica     Hybrid Journal   (Followers: 5, SJR: 0.79, CiteScore: 2)
Adaptation     Hybrid Journal   (Followers: 9, SJR: 0.143, CiteScore: 0)
Advances in Nutrition     Hybrid Journal   (Followers: 53, SJR: 2.196, CiteScore: 5)
Aesthetic Surgery J.     Hybrid Journal   (Followers: 6, SJR: 1.434, CiteScore: 1)
African Affairs     Hybrid Journal   (Followers: 65, SJR: 1.869, CiteScore: 2)
Age and Ageing     Hybrid Journal   (Followers: 91, SJR: 1.989, CiteScore: 4)
Alcohol and Alcoholism     Hybrid Journal   (Followers: 19, SJR: 1.376, CiteScore: 3)
American Entomologist     Full-text available via subscription   (Followers: 7)
American Historical Review     Hybrid Journal   (Followers: 155, SJR: 0.467, CiteScore: 1)
American J. of Agricultural Economics     Hybrid Journal   (Followers: 42, SJR: 2.113, CiteScore: 3)
American J. of Clinical Nutrition     Hybrid Journal   (Followers: 167, SJR: 3.438, CiteScore: 6)
American J. of Epidemiology     Hybrid Journal   (Followers: 188, SJR: 2.713, CiteScore: 3)
American J. of Hypertension     Hybrid Journal   (Followers: 25, SJR: 1.322, CiteScore: 3)
American J. of Jurisprudence     Hybrid Journal   (Followers: 19, SJR: 0.281, CiteScore: 1)
American J. of Legal History     Full-text available via subscription   (Followers: 8, SJR: 0.116, CiteScore: 0)
American Law and Economics Review     Hybrid Journal   (Followers: 27, SJR: 1.053, CiteScore: 1)
American Literary History     Hybrid Journal   (Followers: 16, SJR: 0.391, CiteScore: 0)
Analysis     Hybrid Journal   (Followers: 22, SJR: 1.038, CiteScore: 1)
Animal Frontiers     Hybrid Journal   (Followers: 1)
Annals of Behavioral Medicine     Hybrid Journal   (Followers: 16, SJR: 1.423, CiteScore: 3)
Annals of Botany     Hybrid Journal   (Followers: 36, SJR: 1.721, CiteScore: 4)
Annals of Oncology     Hybrid Journal   (Followers: 56, SJR: 5.599, CiteScore: 9)
Annals of the Entomological Society of America     Full-text available via subscription   (Followers: 10, SJR: 0.722, CiteScore: 1)
Annals of Work Exposures and Health     Hybrid Journal   (Followers: 32, SJR: 0.728, CiteScore: 2)
AoB Plants     Open Access   (Followers: 4, SJR: 1.28, CiteScore: 3)
Applied Economic Perspectives and Policy     Hybrid Journal   (Followers: 18, SJR: 0.858, CiteScore: 2)
Applied Linguistics     Hybrid Journal   (Followers: 57, SJR: 2.987, CiteScore: 3)
Applied Mathematics Research eXpress     Hybrid Journal   (Followers: 1, SJR: 1.241, CiteScore: 1)
Arbitration Intl.     Full-text available via subscription   (Followers: 20)
Arbitration Law Reports and Review     Hybrid Journal   (Followers: 14)
Archives of Clinical Neuropsychology     Hybrid Journal   (Followers: 30, SJR: 0.731, CiteScore: 2)
Aristotelian Society Supplementary Volume     Hybrid Journal   (Followers: 3)
Arthropod Management Tests     Hybrid Journal   (Followers: 2)
Astronomy & Geophysics     Hybrid Journal   (Followers: 44, SJR: 0.146, CiteScore: 0)
Behavioral Ecology     Hybrid Journal   (Followers: 52, SJR: 1.871, CiteScore: 3)
Bioinformatics     Hybrid Journal   (Followers: 317, SJR: 6.14, CiteScore: 8)
Biology Methods and Protocols     Hybrid Journal  
Biology of Reproduction     Full-text available via subscription   (Followers: 9, SJR: 1.446, CiteScore: 3)
Biometrika     Hybrid Journal   (Followers: 20, SJR: 3.485, CiteScore: 2)
BioScience     Hybrid Journal   (Followers: 29, SJR: 2.754, CiteScore: 4)
Bioscience Horizons : The National Undergraduate Research J.     Open Access   (Followers: 1, SJR: 0.146, CiteScore: 0)
Biostatistics     Hybrid Journal   (Followers: 17, SJR: 1.553, CiteScore: 2)
BJA : British J. of Anaesthesia     Hybrid Journal   (Followers: 175, SJR: 2.115, CiteScore: 3)
BJA Education     Hybrid Journal   (Followers: 65)
Brain     Hybrid Journal   (Followers: 68, SJR: 5.858, CiteScore: 7)
Briefings in Bioinformatics     Hybrid Journal   (Followers: 50, SJR: 2.505, CiteScore: 5)
Briefings in Functional Genomics     Hybrid Journal   (Followers: 3, SJR: 2.15, CiteScore: 3)
British J. for the Philosophy of Science     Hybrid Journal   (Followers: 36, SJR: 2.161, CiteScore: 2)
British J. of Aesthetics     Hybrid Journal   (Followers: 25, SJR: 0.508, CiteScore: 1)
British J. of Criminology     Hybrid Journal   (Followers: 592, SJR: 1.828, CiteScore: 3)
British J. of Social Work     Hybrid Journal   (Followers: 85, SJR: 1.019, CiteScore: 2)
British Medical Bulletin     Hybrid Journal   (Followers: 6, SJR: 1.355, CiteScore: 3)
British Yearbook of Intl. Law     Hybrid Journal   (Followers: 33)
Bulletin of the London Mathematical Society     Hybrid Journal   (Followers: 4, SJR: 1.376, CiteScore: 1)
Cambridge J. of Economics     Hybrid Journal   (Followers: 65, SJR: 0.764, CiteScore: 2)
Cambridge J. of Regions, Economy and Society     Hybrid Journal   (Followers: 11, SJR: 2.438, CiteScore: 4)
Cambridge Quarterly     Hybrid Journal   (Followers: 9, SJR: 0.104, CiteScore: 0)
Capital Markets Law J.     Hybrid Journal   (Followers: 2, SJR: 0.222, CiteScore: 0)
Carcinogenesis     Hybrid Journal   (Followers: 2, SJR: 2.135, CiteScore: 5)
Cardiovascular Research     Hybrid Journal   (Followers: 14, SJR: 3.002, CiteScore: 5)
Cerebral Cortex     Hybrid Journal   (Followers: 46, SJR: 3.892, CiteScore: 6)
CESifo Economic Studies     Hybrid Journal   (Followers: 18, SJR: 0.483, CiteScore: 1)
Chemical Senses     Hybrid Journal   (Followers: 1, SJR: 1.42, CiteScore: 3)
Children and Schools     Hybrid Journal   (Followers: 6, SJR: 0.246, CiteScore: 0)
Chinese J. of Comparative Law     Hybrid Journal   (Followers: 4, SJR: 0.412, CiteScore: 0)
Chinese J. of Intl. Law     Hybrid Journal   (Followers: 22, SJR: 0.329, CiteScore: 0)
Chinese J. of Intl. Politics     Hybrid Journal   (Followers: 10, SJR: 1.392, CiteScore: 2)
Christian Bioethics: Non-Ecumenical Studies in Medical Morality     Hybrid Journal   (Followers: 10, SJR: 0.183, CiteScore: 0)
Classical Receptions J.     Hybrid Journal   (Followers: 27, SJR: 0.123, CiteScore: 0)
Clean Energy     Open Access   (Followers: 1)
Clinical Infectious Diseases     Hybrid Journal   (Followers: 67, SJR: 5.051, CiteScore: 5)
Communication Theory     Hybrid Journal   (Followers: 23, SJR: 2.424, CiteScore: 3)
Communication, Culture & Critique     Hybrid Journal   (Followers: 27, SJR: 0.222, CiteScore: 1)
Community Development J.     Hybrid Journal   (Followers: 28, SJR: 0.268, CiteScore: 1)
Computer J.     Hybrid Journal   (Followers: 9, SJR: 0.319, CiteScore: 1)
Conservation Physiology     Open Access   (Followers: 2, SJR: 1.818, CiteScore: 3)
Contemporary Women's Writing     Hybrid Journal   (Followers: 9, SJR: 0.121, CiteScore: 0)
Contributions to Political Economy     Hybrid Journal   (Followers: 5, SJR: 0.906, CiteScore: 1)
Critical Values     Full-text available via subscription  
Current Developments in Nutrition     Open Access   (Followers: 2)
Current Legal Problems     Hybrid Journal   (Followers: 29)
Current Zoology     Full-text available via subscription   (Followers: 3, SJR: 1.164, CiteScore: 2)
Database : The J. of Biological Databases and Curation     Open Access   (Followers: 8, SJR: 1.791, CiteScore: 3)
Digital Scholarship in the Humanities     Hybrid Journal   (Followers: 14, SJR: 0.259, CiteScore: 1)
Diplomatic History     Hybrid Journal   (Followers: 20, SJR: 0.45, CiteScore: 1)
DNA Research     Open Access   (Followers: 5, SJR: 2.866, CiteScore: 6)
Dynamics and Statistics of the Climate System     Open Access   (Followers: 4)
Early Music     Hybrid Journal   (Followers: 16, SJR: 0.139, CiteScore: 0)
Economic Policy     Hybrid Journal   (Followers: 41, SJR: 3.584, CiteScore: 3)
ELT J.     Hybrid Journal   (Followers: 24, SJR: 0.942, CiteScore: 1)
English Historical Review     Hybrid Journal   (Followers: 54, SJR: 0.612, CiteScore: 1)
English: J. of the English Association     Hybrid Journal   (Followers: 15, SJR: 0.1, CiteScore: 0)
Environmental Entomology     Full-text available via subscription   (Followers: 11, SJR: 0.818, CiteScore: 2)
Environmental Epigenetics     Open Access   (Followers: 3)
Environmental History     Hybrid Journal   (Followers: 27, SJR: 0.408, CiteScore: 1)
EP-Europace     Hybrid Journal   (Followers: 3, SJR: 2.748, CiteScore: 4)
Epidemiologic Reviews     Hybrid Journal   (Followers: 9, SJR: 4.505, CiteScore: 8)
ESHRE Monographs     Hybrid Journal  
Essays in Criticism     Hybrid Journal   (Followers: 19, SJR: 0.113, CiteScore: 0)
European Heart J.     Hybrid Journal   (Followers: 62, SJR: 9.315, CiteScore: 9)
European Heart J. - Cardiovascular Imaging     Hybrid Journal   (Followers: 9, SJR: 3.625, CiteScore: 3)
European Heart J. - Cardiovascular Pharmacotherapy     Full-text available via subscription   (Followers: 2)
European Heart J. - Quality of Care and Clinical Outcomes     Hybrid Journal  
European Heart J. : Case Reports     Open Access  
European Heart J. Supplements     Hybrid Journal   (Followers: 8, SJR: 0.223, CiteScore: 0)
European J. of Cardio-Thoracic Surgery     Hybrid Journal   (Followers: 9, SJR: 1.681, CiteScore: 2)
European J. of Intl. Law     Hybrid Journal   (Followers: 194, SJR: 0.694, CiteScore: 1)
European J. of Orthodontics     Hybrid Journal   (Followers: 4, SJR: 1.279, CiteScore: 2)
European J. of Public Health     Hybrid Journal   (Followers: 20, SJR: 1.36, CiteScore: 2)
European Review of Agricultural Economics     Hybrid Journal   (Followers: 10, SJR: 1.172, CiteScore: 2)
European Review of Economic History     Hybrid Journal   (Followers: 30, SJR: 0.702, CiteScore: 1)
European Sociological Review     Hybrid Journal   (Followers: 42, SJR: 2.728, CiteScore: 3)
Evolution, Medicine, and Public Health     Open Access   (Followers: 12)
Family Practice     Hybrid Journal   (Followers: 16, SJR: 1.018, CiteScore: 2)
Fems Microbiology Ecology     Hybrid Journal   (Followers: 15, SJR: 1.492, CiteScore: 4)
Fems Microbiology Letters     Hybrid Journal   (Followers: 28, SJR: 0.79, CiteScore: 2)
Fems Microbiology Reviews     Hybrid Journal   (Followers: 32, SJR: 7.063, CiteScore: 13)
Fems Yeast Research     Hybrid Journal   (Followers: 13, SJR: 1.308, CiteScore: 3)
Food Quality and Safety     Open Access   (Followers: 1)
Foreign Policy Analysis     Hybrid Journal   (Followers: 24, SJR: 1.425, CiteScore: 1)
Forest Science     Hybrid Journal   (Followers: 7, SJR: 0.89, CiteScore: 2)
Forestry: An Intl. J. of Forest Research     Hybrid Journal   (Followers: 16, SJR: 1.133, CiteScore: 3)
Forum for Modern Language Studies     Hybrid Journal   (Followers: 6, SJR: 0.104, CiteScore: 0)
French History     Hybrid Journal   (Followers: 33, SJR: 0.118, CiteScore: 0)
French Studies     Hybrid Journal   (Followers: 21, SJR: 0.148, CiteScore: 0)
French Studies Bulletin     Hybrid Journal   (Followers: 10, SJR: 0.152, CiteScore: 0)
Gastroenterology Report     Open Access   (Followers: 2)
Genome Biology and Evolution     Open Access   (Followers: 13, SJR: 2.578, CiteScore: 4)
Geophysical J. Intl.     Hybrid Journal   (Followers: 36, SJR: 1.506, CiteScore: 3)
German History     Hybrid Journal   (Followers: 23, SJR: 0.161, CiteScore: 0)
GigaScience     Open Access   (Followers: 4, SJR: 5.022, CiteScore: 7)
Global Summitry     Hybrid Journal   (Followers: 1)
Glycobiology     Hybrid Journal   (Followers: 13, SJR: 1.493, CiteScore: 3)
Health and Social Work     Hybrid Journal   (Followers: 56, SJR: 0.388, CiteScore: 1)
Health Education Research     Hybrid Journal   (Followers: 16, SJR: 0.854, CiteScore: 2)
Health Policy and Planning     Hybrid Journal   (Followers: 24, SJR: 1.512, CiteScore: 2)
Health Promotion Intl.     Hybrid Journal   (Followers: 22, SJR: 0.812, CiteScore: 2)
History Workshop J.     Hybrid Journal   (Followers: 31, SJR: 1.278, CiteScore: 1)
Holocaust and Genocide Studies     Hybrid Journal   (Followers: 28, SJR: 0.105, CiteScore: 0)
Human Communication Research     Hybrid Journal   (Followers: 15, SJR: 2.146, CiteScore: 3)
Human Molecular Genetics     Hybrid Journal   (Followers: 9, SJR: 3.555, CiteScore: 5)
Human Reproduction     Hybrid Journal   (Followers: 72, SJR: 2.643, CiteScore: 5)
Human Reproduction Open     Open Access  
Human Reproduction Update     Hybrid Journal   (Followers: 19, SJR: 5.317, CiteScore: 10)
Human Rights Law Review     Hybrid Journal   (Followers: 61, SJR: 0.756, CiteScore: 1)
ICES J. of Marine Science: J. du Conseil     Hybrid Journal   (Followers: 56, SJR: 1.591, CiteScore: 3)
ICSID Review     Hybrid Journal   (Followers: 10)
ILAR J.     Hybrid Journal   (Followers: 2, SJR: 1.732, CiteScore: 4)
IMA J. of Applied Mathematics     Hybrid Journal   (SJR: 0.679, CiteScore: 1)
IMA J. of Management Mathematics     Hybrid Journal   (SJR: 0.538, CiteScore: 1)
IMA J. of Mathematical Control and Information     Hybrid Journal   (Followers: 2, SJR: 0.496, CiteScore: 1)
IMA J. of Numerical Analysis - advance access     Hybrid Journal   (SJR: 1.987, CiteScore: 2)
Industrial and Corporate Change     Hybrid Journal   (Followers: 10, SJR: 1.792, CiteScore: 2)
Industrial Law J.     Hybrid Journal   (Followers: 37, SJR: 0.249, CiteScore: 1)
Inflammatory Bowel Diseases     Hybrid Journal   (Followers: 48, SJR: 2.511, CiteScore: 4)
Information and Inference     Free  
Integrative and Comparative Biology     Hybrid Journal   (Followers: 8, SJR: 1.319, CiteScore: 2)
Interacting with Computers     Hybrid Journal   (Followers: 11, SJR: 0.292, CiteScore: 1)
Interactive CardioVascular and Thoracic Surgery     Hybrid Journal   (Followers: 7, SJR: 0.762, CiteScore: 1)
Intl. Affairs     Hybrid Journal   (Followers: 63, SJR: 1.505, CiteScore: 3)
Intl. Data Privacy Law     Hybrid Journal   (Followers: 25)
Intl. Health     Hybrid Journal   (Followers: 6, SJR: 0.851, CiteScore: 2)
Intl. Immunology     Hybrid Journal   (Followers: 3, SJR: 2.167, CiteScore: 4)
Intl. J. for Quality in Health Care     Hybrid Journal   (Followers: 36, SJR: 1.348, CiteScore: 2)
Intl. J. of Constitutional Law     Hybrid Journal   (Followers: 64, SJR: 0.601, CiteScore: 1)
Intl. J. of Epidemiology     Hybrid Journal   (Followers: 240, SJR: 3.969, CiteScore: 5)
Intl. J. of Law and Information Technology     Hybrid Journal   (Followers: 5, SJR: 0.202, CiteScore: 1)
Intl. J. of Law, Policy and the Family     Hybrid Journal   (Followers: 25, SJR: 0.223, CiteScore: 1)
Intl. J. of Lexicography     Hybrid Journal   (Followers: 10, SJR: 0.285, CiteScore: 1)
Intl. J. of Low-Carbon Technologies     Open Access   (Followers: 1, SJR: 0.403, CiteScore: 1)
Intl. J. of Neuropsychopharmacology     Open Access   (Followers: 3, SJR: 1.808, CiteScore: 4)
Intl. J. of Public Opinion Research     Hybrid Journal   (Followers: 11, SJR: 1.545, CiteScore: 1)
Intl. J. of Refugee Law     Hybrid Journal   (Followers: 38, SJR: 0.389, CiteScore: 1)
Intl. J. of Transitional Justice     Hybrid Journal   (Followers: 11, SJR: 0.724, CiteScore: 2)
Intl. Mathematics Research Notices     Hybrid Journal   (Followers: 1, SJR: 2.168, CiteScore: 1)
Intl. Political Sociology     Hybrid Journal   (Followers: 39, SJR: 1.465, CiteScore: 3)
Intl. Relations of the Asia-Pacific     Hybrid Journal   (Followers: 23, SJR: 0.401, CiteScore: 1)
Intl. Studies Perspectives     Hybrid Journal   (Followers: 9, SJR: 0.983, CiteScore: 1)
Intl. Studies Quarterly     Hybrid Journal   (Followers: 47, SJR: 2.581, CiteScore: 2)
Intl. Studies Review     Hybrid Journal   (Followers: 25, SJR: 1.201, CiteScore: 1)
ISLE: Interdisciplinary Studies in Literature and Environment     Hybrid Journal   (Followers: 2, SJR: 0.15, CiteScore: 0)
ITNOW     Hybrid Journal   (Followers: 1, SJR: 0.103, CiteScore: 0)
J. of African Economies     Hybrid Journal   (Followers: 16, SJR: 0.533, CiteScore: 1)
J. of American History     Hybrid Journal   (Followers: 46, SJR: 0.297, CiteScore: 1)
J. of Analytical Toxicology     Hybrid Journal   (Followers: 14, SJR: 1.065, CiteScore: 2)
J. of Antimicrobial Chemotherapy     Hybrid Journal   (Followers: 15, SJR: 2.419, CiteScore: 4)
J. of Antitrust Enforcement     Hybrid Journal   (Followers: 1)
J. of Applied Poultry Research     Hybrid Journal   (Followers: 5, SJR: 0.585, CiteScore: 1)
J. of Biochemistry     Hybrid Journal   (Followers: 40, SJR: 1.226, CiteScore: 2)
J. of Burn Care & Research     Hybrid Journal   (Followers: 10, SJR: 0.768, CiteScore: 2)
J. of Chromatographic Science     Hybrid Journal   (Followers: 18, SJR: 0.36, CiteScore: 1)
J. of Church and State     Hybrid Journal   (Followers: 12, SJR: 0.139, CiteScore: 0)
J. of Communication     Hybrid Journal   (Followers: 55, SJR: 4.411, CiteScore: 5)
J. of Competition Law and Economics     Hybrid Journal   (Followers: 37, SJR: 0.33, CiteScore: 0)
J. of Complex Networks     Hybrid Journal   (Followers: 2, SJR: 1.05, CiteScore: 4)
J. of Computer-Mediated Communication     Open Access   (Followers: 29, SJR: 2.961, CiteScore: 6)
J. of Conflict and Security Law     Hybrid Journal   (Followers: 13, SJR: 0.402, CiteScore: 0)
J. of Consumer Research     Full-text available via subscription   (Followers: 47, SJR: 5.856, CiteScore: 5)
J. of Crohn's and Colitis     Hybrid Journal   (Followers: 10, SJR: 2.728, CiteScore: 5)

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Journal Cover
American Journal of Hypertension
Journal Prestige (SJR): 1.322
Citation Impact (citeScore): 3
Number of Followers: 25  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0895-7061 - ISSN (Online) 1941-7225
Published by Oxford University Press Homepage  [396 journals]
  • Abstract from the Chinese Journal of Hypertension
    • Pages: 223 - 224
      Abstract: The Interaction Between Environmental Factors and DNA Methylation of Angiotensin II Type 1 Receptor Gene in Coronary Artery Disease
      PubDate: Tue, 15 Jan 2019 00:00:00 GMT
      DOI: 10.1093/ajh/hpy194
      Issue No: Vol. 32, No. 2 (2019)
  • Abstract from the Chinese Journal of Hypertension
    • Pages: 223 - 223
      Abstract: The Prevalence and Influential Factors of Masked Hypertension in the Elderly Population
      PubDate: Tue, 15 Jan 2019 00:00:00 GMT
      DOI: 10.1093/ajh/hpy195
      Issue No: Vol. 32, No. 2 (2019)
  • Genetic Polymorphisms in Hypertension: Are We Missing the Immune
    • Authors: Rodriguez-Iturbe B; Johnson R.
      Pages: 113 - 122
      Abstract: High blood pressure (defined here as blood pressure ≥140/90 mm Hg) is the cause of 9.4 million deaths each year1 and represents the most important modifiable risk factor for death due to cardiovascular disease.2 Hypertension may be secondary to a number of causes and is a feature in rare monogenic variants, but the vast majority of the patients with hypertension do not have a specific etiology and are grouped under the label of essential or primary hypertension. Familial studies have suggested the heritability of blood pressure levels,3,4 and essential hypertension is considered to be the result of the combination of a number of genes and protein-to-protein interactions in association with environmental influences.5 A number of genome-wide association studies (GWAS) have considered hypertension a quantitative trait and examined the incidence of single nucleotide polymorphisms (SNPs) in hypertensive patients; to date, more than 90 different genetic polymorphisms that appear to associate with high blood pressure have been identified.6 Most interest in the genetic polymorphisms linked with hypertension has focused on the genes involved in sodium transport, on vasoactive hormones or genes involved in regulation of sympathetic–parasympathetic activity, or the renin–angiotensin system or other systems regulating vascular tone. However, association of these genetic variants with potential modifications in circulatory homeostasis has generally been disappointing.6
      PubDate: Sat, 10 Nov 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy168
      Issue No: Vol. 32, No. 2 (2018)
  • Vascular Mineralocorticoid Receptor: Evolutionary Mediator of Wound
           Healing Turned Harmful by Our Modern Lifestyle
    • Authors: Biwer L; Wallingford M, Jaffe I.
      Pages: 123 - 134
      Abstract: The mineralocorticoid receptor (MR) is indispensable for survival through its critical role in maintaining blood pressure in response to sodium scarcity or bleeding. Activation of MR by aldosterone in the kidney controls water and electrolyte homeostasis. This review summarizes recent advances in our understanding of MR function, specifically in vascular endothelial and smooth muscle cells. The evolving roles for vascular MR are summarized in the areas of (i) vascular tone regulation, (ii) thrombosis, (iii) inflammation, and (iv) vascular remodeling/fibrosis. Synthesis of the data supports the concept that vascular MR does not contribute substantially to basal homeostasis but rather, MR is poised to be activated when the vasculature is damaged to coordinate blood pressure maintenance and wound healing. Specifically, MR activation in the vascular wall promotes vasoconstriction, inflammation, and exuberant vascular remodeling with fibrosis. A teleological model is proposed in which these functions of vascular MR may have provided a critical evolutionary survival advantage in the face of mechanical vascular injury with bleeding. However, modern lifestyle is characterized by physical inactivity and high fat/high sodium diet resulting in diffuse vascular damage. Under these modern conditions, diffuse, persistent and unregulated activation of vascular MR contributes to post-reproductive cardiovascular disease in growing populations with hypertension, obesity, and advanced age.
      PubDate: Wed, 31 Oct 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy158
      Issue No: Vol. 32, No. 2 (2018)
  • Beet Juice as Nutraceutical Remedy for Alleviating Pulmonary Arterial
           Hypertension: Searching for Optimal Treatment Timing and Nitrate Dose
    • Authors: Xi L.
      Pages: 135 - 138
      Abstract: Pulmonary arterial hypertension (PAH) is a relatively rare, progressive disorder characterized by high blood pressure in the arteries of the lungs, which eventually leads to devastating health outcomes (including right heart failure) without a known cure.1 PAH usually affects women between the ages of 30 and 60 years and 15%–20% of patients have heritable forms of PAH, whereas other forms of PAH have various etiologies such as chronic obstructive pulmonary disease and pulmonary emboli, which cause pulmonary capillary hemangiomatosis or veno-occlusive disease, as well as left heart failure. Recent multicohort investigation revealed a new circulating biomarker approach with genetic analysis for differentiating the 2 subtypes of PAH2 and thereby would provide better advice for drug selection for vasodilator-responsive PAH vs. vasodilator-nonresponsive PAH, which has much worse clinical outcomes. The current lines of the US Food and Drug Administration-approved drug therapy for PAH include the following: (i) prostaglandins, (ii) endothelin receptor antagonists, and (iii) phosphodiesterase 5 inhibitors. Oral combination therapy is commonly used in managing more difficult cases of PAH.
      PubDate: Tue, 18 Dec 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy181
      Issue No: Vol. 32, No. 2 (2018)
  • Blood Pressure Measurement Challenges in Severely Obese Patients
    • Authors: Siddiqui M; Calhoun D.
      Pages: 139 - 140
      Abstract: The recent 2017 American College of Cardiology/American Heart Association blood pressure (BP) guidelines emphasized the importance of utilizing good technique when measuring BP, including use of a properly sized arm cuff. Specific recommendations in this regard require that the cuff bladder encircle 80% of the upper arm. In most adults, selection of a properly fitting cuff from routinely available cuff sizes is not a problem, but for extremely obese patients, it often is, such that accurately measuring BP in extremely obese patients is a common clinical problem because of the extremely large arm sizes.1–4 In severely obese patients, BP measurement is challenging because the BP cuff is simply too small and/or fits poorly around the large, conically shaped upper arm. This cuff/arm mismatch can result in so-called hidden under-cuffing, i.e., use of a cuff bladder that is too small and/or too narrow for the patient’s arm size, resulting in falsely elevated BP values.5–8
      PubDate: Thu, 01 Nov 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy162
      Issue No: Vol. 32, No. 2 (2018)
  • How to Improve Patients’ Adherence to Antihypertensive Therapy: A Simple
           Solution for a Big Trouble
    • Authors: Tocci G; Presta V, Volpe M.
      Pages: 141 - 142
      Abstract: Worldwide control of essential hypertension is suboptimal. Several epidemiological studies and clinical surveys have independently and repeatedly shown that the proportions of treated hypertensive patients who achieved the recommended blood pressure (BP) targets (i.e., systolic/diastolic BP levels below 140/90 mm Hg) ranged from about 20% to 45% in the general population, with even lower proportions reported in high or very high cardiovascular risk individuals.1,2 Such estimations might be reconsidered after the publication of the latest sets of both North American and European guidelines on hypertension, which have redefined the BP targets to be achieved under pharmacological therapies in different age strata and clinical settings.3
      PubDate: Fri, 30 Nov 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy179
      Issue No: Vol. 32, No. 2 (2018)
  • Impact of Single-Occasion American vs. Canadian Office Blood Pressure
           Measurement Recommendations on Blood Pressure Classification
    • Authors: Vischer A; Mayr M, Socrates T, et al.
      Pages: 143 - 145
      Abstract: BACKGROUNDThe 2017 American hypertension guidelines [American College of Cardiology/American Heart Association (ACC/AHA)] define a blood pressure measurement (BPM) procedure that differs from the Canadian Hypertension Education Program (CHEP) guidelines. We studied the impact of the BPM procedure on arterial hypertension (AHT) prevalence rate.METHODSIn 805 subjects, the mean of the first and second BPM (adapted ACC/AHA procedure) was compared with the mean of the second and third BPM (CHEP procedure). All BPMs were taken at a single occasion. According to ACC/AHA definition, office blood pressure (OBP) of <120/80 mm Hg was classified as normal, 120–129/<80 mm Hg as elevated, and ≥130/80 mm Hg as hypertensive.RESULTSUsing the adapted ACC/AHA BPM procedure compared to the CHEP BPM procedure led to an increase in the AHT prevalence rate (≥130/80 mm Hg) of 4% (58% vs. 54%). Overall, 8.9% (72/805) of subjects were reclassified to a higher and 2.6% (21/805) to a lower blood pressure category when using the adapted ACC/AHA BPM procedure instead of the CHEP BPM procedure. In the group with elevated OBP (120–129/<80 mm Hg), 41.9% (36/86) of subjects were reclassified.CONCLUSIONSMinimal changes of BPM procedures lead to relevant changes of hypertension prevalence.CLINICAL TRIALS REGISTRATIONTrial Number NCT02552030.
      PubDate: Mon, 29 Oct 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy159
      Issue No: Vol. 32, No. 2 (2018)
  • Heart-to-Brachium Pulse Wave Velocity as a Measure of Proximal Aortic
           Stiffness: MRI and Longitudinal Studies
    • Authors: Sugawara J; Tomoto T, Tanaka H.
      Pages: 146 - 154
      Abstract: BACKGROUNDStiffening of the proximal aorta is associated with heightened cardiovascular disease risks but can be quantified by limited methodologies (e.g., magnetic resonance imaging [MRI]). As an initial step to evaluate the emerging technique to assess proximal aortic stiffness via pulse wave velocity from the heart to the brachium (hbPWV), we determined the influences of aging on pulse wave velocity (PWV) and aortic hemodynamics.METHODUsing the cross-sectional and follow-up study designs, hbPWV was compared and evaluated in relation to other PWV in various arterial segments. Arterial path lengths were measured by the 3-dimensional arterial tracing of MRI.RESULTSIn the cross-sectional study including 190 subjects (aged 19–79 years), hbPWV exhibited one of the largest age-related increases and a stronger correlation with age (r = 0.790) compared with the other measures of PWV including carotid-femoral PWV, brachial-ankle PWV, and PWV of muscular arteries (r = 0.445–0.688). In addition, hbPWV was correlated with aortic systolic blood pressure (BP) and augmentation index (r = 0.380 and 0.433, respectively) after controlling for brachial systolic BP. These results were confirmed by the 10-year follow-up study involving 84 individuals (53 years at baseline). The decadal changes in hbPWV were significantly correlated with the corresponding changes in several aortic hemodynamic variables (e.g., aortic systolic BP, augmentation pressure, and augmentation index) (r = 0.240–0.349).CONCLUSIONSThe present findings indicate that hbPWV is a potential marker of proximal aortic stiffening that reflects age-related changes and aortic hemodynamics.
      PubDate: Fri, 16 Nov 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy166
      Issue No: Vol. 32, No. 2 (2018)
  • Speckle-Tracking Echocardiographic Layer-Specific Strain Analysis on
           Subclinical Left Ventricular Dysfunction in Patients With Primary
    • Authors: Wang D; Xu J, Chen X, et al.
      Pages: 155 - 162
      Abstract: BACKGROUNDPrimary aldosteronism (PA) may cause myocardial injury. We investigated myocardial dysfunction using speckle-tracking echocardiographic (STE) layer-specific strain in patients with PA.METHODSOur study included 62 patients with PA (33 aldosterone-producing adenoma [APA] and 29 idiopathic hyperaldosteronism [IHA]) and 30 patients with primary hypertension. STE was acquired using the GE Vivid E9 equipment. The longitudinal (LS) and circumferential (CS) layer-specific strains of the endocardium, midmyocardium, and epicardium (LSendo, LSmid, LSepi, CSendo, CSmid, and CSepi) were obtained using the EchoPAC BT13 workstation.RESULTSPatients with APA, compared with those with primary hypertension and IHA, had a significantly (P < 0.001) lower serum potassium concentration and plasma renin activity, and higher 24-h urinary aldosterone, plasma aldosterone concentration, and aldosterone-to-renin ratio. Left ventricular ejection fraction was normal in all patients (58–60%). Layer-specific strain showed decreasing gradient from the endocardium to epicardium in all 3 groups (P < 0.01). However, LSendo and CSendo were lowest in APA (−20.2 ± 2.3% and −33.3 ± 3.2%), intermediate in IHA (–22.1 ± 1.9% and −35.7 ± 2.8%) and highest in primary hypertension (–24.1 ± 2.1% and −38.9 ± 3.1%, P < 0.001). Similar trends were observed for LSmid, LSepi, CSmid, and CSepi, but statistical significance was only reached for the comparison between APA and primary hypertension (P < 0.001), but not others (P > 0.05). Layer-specific strain was significantly correlated with plasma aldosterone concentration for all echocardiographic parameters (r = −0.69 to −0.53, P < 0.001) in all 3 groups.CONCLUSIONSPatients with PA, especially APA, had impaired regional systolic function with myocardial deformation changes at similar levels of blood pressure, probably because of elevated plasma aldosterone concentration.
      PubDate: Wed, 21 Nov 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy175
      Issue No: Vol. 32, No. 2 (2018)
  • Effect Modification by Age on the Benefit or Harm of Antihypertensive
           Treatment for Elderly Hypertensives: A Systematic Review and Meta-analysis
    • Authors: Huang C; Chiang C, Williams B, et al.
      Pages: 163 - 174
      Abstract: BACKGROUNDThe influence of age on balance of benefit vs. potential harm of blood pressure (BP)-lowering therapy for elderly hypertensives is unclear. We evaluated the modifying effects of age on BP lowering for various adverse outcomes in hypertensive patients older than 60 years without specified comorbidities.METHODSAll relevant randomized controlled trials (RCTs) were systematically identified. Coronary heart disease, stroke, heart failure (HF), cardiovascular death, major adverse cardiovascular events (MACE), renal failure (RF), and all-cause death were assessed. Meta-regression analysis was used to explore the relationship between achieved systolic BP (SBP) and the risk of adverse events. Random-effects meta-analysis was used to pool the estimates.RESULTSOur study included 18 RCTs (n = 53,993). Meta-regression analysis showed a lower achieved SBP related with a lower risk of stroke and cardiovascular death, but an increased risk of RF. The regression slopes were comparable between populations stratifying by age 75 years. In subgroup analysis, the relative risks of a more aggressive BP lowering strategy were similar between patients aged older or less than 75 years for all outcomes except for RF (P for interaction = 0.02). Compared to treatment with final achieved SBP 140–150 mm Hg, a lower achieved SBP (<140 mm Hg) was significantly associated with decreased risk of stroke (relative risk = 0.68; 95% confidence interval = 0.55–0.85), HF (0.77; 0.60–0.99), cardiovascular death (0.68; 0.52–0.89), and MACE (0.83; 0.69–0.99).CONCLUSIONSTo treat hypertension in the elderly, age had trivial effect modification on most outcomes, except for renal failure. Close monitoring of renal function may be warranted in the management of elderly hypertension.
      PubDate: Fri, 16 Nov 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy169
      Issue No: Vol. 32, No. 2 (2018)
  • Blood Pressure Measurement in Severely Obese Patients: Validation of the
           Forearm Approach in Different Arm Positions
    • Authors: Leblanc M; Auclair A, Leclerc J, et al.
      Pages: 175 - 185
      Abstract: BACKGROUNDBlood pressure measurement in severe obesity may be technically challenging as the cuff of the device may not fit adequately around the upper arm. The aim of the study was to assess the agreement between intra-arterial blood pressure values (gold standard) compared with forearm blood pressure measurements in severely obese patients in different arm positions.METHODSThirty-three severely obese patients and 21 controls participated in the study. Pairs of intra-arterial blood pressures were compared with simultaneous forearm blood pressure measurement using an oscillometric device in 4 positions: (i) supine, (ii) semi-fowler with the forearm resting at heart level, (iii) semi-fowler with the arm downward, and (iv) semi-fowler with the arm raised overhead. Degree of agreement between measurements was assessed.RESULTSOverall, correlations of systolic and diastolic blood pressure measurements between the gold standard and forearm blood pressure were 0.95 (n = 722; P < 0.001) and 0.89 (n = 482; P < 0.001), respectively. Systolic blood pressure measured using the forearm approach in the supine and the semi-fowler positions with arm downward showed the best agreement when compared with the gold standard (−4 ± 11 (P < 0.001) and 2 ± 14 mm Hg (P = 0.19), respectively). In the control group, better agreement was found between the supine and semi-fowler positions with the arm resting at heart level (1 ± 9 mm Hg (P = 0.29) and −3 ± 10 mm Hg (P = 0.01), respectively).CONCLUSIONSForearm systolic blood pressure consistently agreed with the gold standard in the supine position. This method can be of use in clinical settings when upper-arm measurement is challenging in severe obesity.
      PubDate: Fri, 12 Oct 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy152
      Issue No: Vol. 32, No. 2 (2018)
  • The Effectiveness of Home Blood Pressure on 24-Hour Blood Pressure
           Control: A Randomized Controlled Trial
    • Authors: Cuffee Y; Sciamanna C, Gerin W, et al.
      Pages: 186 - 192
      Abstract: BACKGROUNDHome blood pressure monitoring (HBPM) is cited as an effective approach for improving blood pressure control. The objective of this study was to determine the effectiveness of HBPM combined with a health education session in reducing blood pressure and improving medication adherence among adults with hypertension.METHODSTwo hundred thirteen participants were enrolled in a 3-month study and randomized to receive HBPM or usual care. Participants were also randomized to receive an educational session delivered using a pamphlet or a computer-based program. Topics of the educational session included preventing hypertension, managing weight, staying active, and cutting down on salt and fat.RESULTSAt the 3-month follow-up, there was a reduction in ambulatory blood pressure among the HBPM group. However, the differences found within the HBPM group were no greater than those found among the control group. We did not detect a statistically significant difference in adherence to medication when comparing the HBPM to the usual care group.CONCLUSIONSHBPM and educational session did not lower blood pressure or improve medication adherence in our sample. A greater effect may have been seen if coupled with an enhanced educational intervention and if blood pressure measures were shared with the provided. The findings of this study provide useful insights for future HBPM studies.
      PubDate: Mon, 29 Oct 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy160
      Issue No: Vol. 32, No. 2 (2018)
  • Association of Periodontal Disease and Edentulism With Hypertension Risk
           in Postmenopausal Women
    • Authors: Gordon J; LaMonte M, Zhao J, et al.
      Pages: 193 - 201
      Abstract: BACKGROUNDMultiple cross-sectional epidemiologic studies have suggested an association between periodontal disease and tooth loss and hypertension, but the temporality of these associations remains unclear. The objective of our study was to evaluate the association of baseline self-reported periodontal disease and edentulism with incident hypertension.METHODSStudy participants were 36,692 postmenopausal women in the Women’s Health Initiative-Observational Study who were followed annually from initial periodontal assessment (1998–2003) through 2015 (mean follow-up 8.3 years) for newly diagnosed treated hypertension. Cox proportional hazards regression with adjustment for potential confounders was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).RESULTSEdentulism was significantly associated with incident hypertension in crude (HR (95% CI) = 1.38 (1.28–1.49)) and adjusted (HR (95% CI) = 1.21 (1.11–1.30)) models. This association was stronger among those <60 years compared to ≥60 years (P interaction 0.04) and among those with <120 mm Hg systolic blood pressure, compared to those with ≥120 mm Hg (P interaction 0.004). No association was found between periodontal disease and hypertension.CONCLUSIONSThese findings suggest that edentulous postmenopausal women may represent a group with higher risk of developing future hypertension. As such improved dental hygiene among those at risk for tooth loss as well as preventive measures among the edentulous such as closer blood pressure monitoring, dietary modification, physical activity, and weight loss may be warranted to reduce disease burden of hypertension. Further studies are needed to clarify these results and further elucidate a potential role of periodontal conditions on hypertension risk.
      PubDate: Tue, 04 Dec 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy164
      Issue No: Vol. 32, No. 2 (2018)
  • Time to First Cigarette and the Risk of Hypertension: A Nationwide
           Representative Study in Korea
    • Authors: Bae J; Yi Y, Kim Y, et al.
      Pages: 202 - 208
      Abstract: BACKGROUNDAlthough previous studies have explored the effect of smoking on blood pressure, little is still known about the role of time to first cigarette (TTFC)—an indicator of nicotine dependence—in hypertension. Therefore, we evaluated this association using representative nationwide data.METHODSCurrent daily smokers (N = 941; aged 19–79 years) who participated in the 7th version of the Korea National Health and Nutrition Examination Survey I (2016) were included. We categorized participants into 4 groups according to their TTFC. Furthermore, we categorized participants into hypertensive and nonhypertensive groups based on whether they were taking antihypertensive medications or had high blood pressure (≥140/90 mm Hg). The association of daily TTFC and hypertension was examined without adjusting for any covariates; after adjusting for smoking behaviors; and after adjusting for demographic characteristics, socioeconomic status, health-related behaviors, and comorbidities.RESULTSIn the fully adjusted weighted regression analysis, participants reporting TTFC ≤ 5 minutes (vs. >60 minutes) had roughly twice the odds of having hypertension (95% confidence interval [CI] = 1.07–4.16) and the adjusted odds ratios compared with TTFC of >60 minutes were 1.53 (95% CI = 0.81–2.86) for 6–30 minutes and 1.31 (95% CI = 0.68–2.50) for 31–60 minutes (Ptrend = 0.03).CONCLUSIONSHypertension risk increases with shorter TTFC. Especially, TTFC of ≤5 minutes may prove valuable in assessing the risk of hypertension. Screening smokers based on their TTFC might be useful in assessing their risk of hypertension and smoking cessation programs.
      PubDate: Sat, 17 Nov 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy170
      Issue No: Vol. 32, No. 2 (2018)
  • The Association Between Tea Consumption and Hyperhomocysteine in Chinese
           Hypertensive Patients
    • Authors: Zhu J; Wang W, Xiong Y, et al.
      Pages: 209 - 215
      Abstract: BACKGROUNDThere is no consistent evidence for the relationship between tea-drinking and hyperhomocysteine (hHcy). Because tea-drinking habit and hHcy have prevailed in Chinese hypertensive patients, this study aimed to investigate the association between hHcy and tea consumption in patients with hypertension.METHODSA total of 335 hypertensive participants were recruited from 7 communities. Demographic characteristics of participants were collected through face-to-face interviews using a standard questionnaire, whereas laboratory data were obtained within 1 week after patient recruitment. Multiple logistic regression analysis was performed to examine the association between tea consumption and hHcy in hypertensive patients.RESULTSOf the 335 patients, 245 had a tea-drinking habit, and 252 of them were detected with hHcy. A significant association was found between tea consumption and hHcy in hypertensive patients (adjusted odds ratio [OR] = 1.84, 95% confidence interval [CI] = 1.01–3.36, P = 0.048). Subgroup analyses showed that black tea drinking group (adjusted OR = 8.81, 95% CI = 2.74–28.33, P < 0.001) was significantly associated with the risk of hHcy, but not oolong and green tea drinking groups (P > 0.05). Furthermore, consuming a small amount (≤1 cup per day) of green tea was negatively associated with hHcy (adjusted OR = 0.19, 95% CI = 0.07–0.51, P = 0.001), whereas a large intake (>3 cups per day) of green tea was associated with high odds of hHcy (adjusted OR = 5.00, 95% CI = 1.33–18.79, P = 0.02).CONCLUSIONSThese data suggest a hypothesis that selecting green tea or limiting tea consumption might reduce risk of hHcy in hypertensive patients and that warrants further study.
      PubDate: Wed, 31 Oct 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy163
      Issue No: Vol. 32, No. 2 (2018)
  • Effects of Beet Juice Supplementation on Monocrotaline-Induced Pulmonary
           Hypertension in Rats
    • Authors: Tawa M; Yano Y, Yamanaka M, et al.
      Pages: 216 - 222
      Abstract: BACKGROUNDRecently, attention has been focused on the cardiovascular protective effects of beet juice (BJ) with high amounts of nitrate. In this study, we examined the effect of BJ supplementation in a rat model of monocrotaline (MCT)-induced pulmonary hypertension (PH).METHODSMCT (60 mg/kg) was subcutaneously administered to rats, and BJ (prepared by dissolving BJ powder at a concentration of 1 g/l or 10 g/l in drinking water) supplementation was started from the day of, 1 week before, and 2 weeks after MCT injection. Saline-injected rats given drinking water were used as controls.RESULTSLow-dose BJ supplementation starting from the day of MCT injection exerted protective effects on the MCT-induced elevation of right ventricular systolic pressure, right ventricular hypertrophy, and pulmonary arterial remodeling, without causing a significant increase in plasma nitrite plus nitrate (NOx) levels. On the other hand, such beneficial effects were not observed with high-dose BJ supplementation, although the NOx levels were slightly higher than those in the low-dose group. In addition, low-dose BJ supplementation starting from 1 week before MCT injection did not improve PH symptoms, as described above. Furthermore, low-dose BJ supplementation starting from 2 weeks after MCT injection was ineffective against functional and morphological alterations in pulmonary circulation associated with MCT-induced PH.CONCLUSIONSHabitual ingestion of a suitable amount of BJ could be a potential option for preventing PH. However, beneficial effects cannot be expected when PH has developed to some degree.
      PubDate: Fri, 28 Sep 2018 00:00:00 GMT
      DOI: 10.1093/ajh/hpy144
      Issue No: Vol. 32, No. 2 (2018)
School of Mathematical and Computer Sciences
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