Publisher: African Journals Online   (Total: 263 journals)

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Showing 1 - 200 of 263 Journals sorted alphabetically
Abia State University Medical Students' Association J.     Full-text available via subscription   (Followers: 2)
Acta Structilia : J. for the Physical and Development Sciences     Open Access   (Followers: 3)
Acta Theologica     Open Access   (Followers: 12, SJR: 0.282, CiteScore: 0)
Africa Development     Open Access   (Followers: 34, SJR: 0.155, CiteScore: 0)
Africa Sanguine     Full-text available via subscription   (Followers: 1)
African Anthropologist     Open Access   (Followers: 16)
African Crop Science J.     Open Access   (Followers: 4)
African Health Sciences     Open Access   (Followers: 4, SJR: 0.446, CiteScore: 1)
African J. of Anaesthesia and Intensive Care     Full-text available via subscription   (Followers: 9)
African J. of Biomedical Research     Open Access   (Followers: 1, SJR: 0.145, CiteScore: 0)
African J. of Chemical Education     Open Access   (Followers: 5)
African J. of Clinical and Experimental Microbiology     Open Access   (Followers: 4, SJR: 0.192, CiteScore: 0)
African J. of Cross-Cultural Psychology and Sport Facilitation     Full-text available via subscription   (Followers: 6)
African J. of Drug and Alcohol Studies     Full-text available via subscription   (Followers: 6, SJR: 0.168, CiteScore: 0)
African J. of Economic Policy     Full-text available via subscription   (Followers: 2)
African J. of Educational Studies in Mathematics and Sciences     Full-text available via subscription   (Followers: 9)
African J. of Food, Agriculture, Nutrition and Development     Open Access   (Followers: 26, SJR: 0.115, CiteScore: 0)
African J. of Governance and Development     Full-text available via subscription   (Followers: 6)
African J. of Health Professions Education     Open Access   (Followers: 6)
African J. of Infectious Diseases     Full-text available via subscription   (SJR: 0.243, CiteScore: 0)
African J. of Livestock Extension     Full-text available via subscription   (Followers: 2)
African J. of Neurological Sciences     Open Access  
African J. of Physiotherapy and Rehabilitation Sciences     Open Access   (Followers: 10)
African J. of Reproductive Health     Open Access   (Followers: 8, SJR: 0.381, CiteScore: 1)
African J. of Rheumatology     Full-text available via subscription   (Followers: 1)
African J. of Social Work     Open Access   (Followers: 1)
African J. of Sustainable Development     Full-text available via subscription   (Followers: 9)
African J. of Traditional, Complementary and Alternative Medicines     Open Access   (Followers: 6)
African J. on Conflict Resolution     Open Access   (Followers: 27)
African Research Review     Open Access   (Followers: 9)
African Review of Economics and Finance     Open Access   (Followers: 9)
African Sociological Review : Revue Africaine de Sociologie     Open Access   (Followers: 3)
Afrika Statistika     Open Access   (Followers: 1)
Afrimedic J.     Open Access   (Followers: 2)
Afrique Science : Revue Intl.e des Sciences et Technologie     Open Access   (Followers: 2)
AFRREV IJAH : An Intl. J. of Arts and Humanities     Open Access   (Followers: 6)
AFRREV LALIGENS : An Intl. J. of Language, Literature and Gender Studies     Open Access   (Followers: 6)
AFRREV STECH : An Intl. J. of Science and Technology     Open Access   (Followers: 3)
Agro-Science     Full-text available via subscription   (Followers: 2)
Agronomie Africaine     Full-text available via subscription  
Agrosearch     Open Access   (Followers: 2)
Animal Research Intl.     Full-text available via subscription   (Followers: 8)
Annales des Sciences Agronomiques     Full-text available via subscription  
Annals of African Surgery     Open Access  
Annals of Biomedical Sciences     Full-text available via subscription   (Followers: 4)
Annals of Humanities and Development Studies     Open Access   (Followers: 7)
Annals of Ibadan Postgraduate Medicine     Open Access  
Annals of Modern Education     Full-text available via subscription   (Followers: 6)
Arab J. of Nephrology and Transplantation     Open Access   (Followers: 1)
Archives of Medical and Biomedical Research     Open Access   (Followers: 3)
ATBU J. of Environmental Technology     Open Access   (Followers: 5)
Bayero J. of Pure and Applied Sciences     Open Access   (Followers: 3)
Bio-Research     Full-text available via subscription   (Followers: 5)
Biokemistri     Open Access  
Botswana J. of Economics     Open Access   (Followers: 1)
Botswana J. of Technology     Full-text available via subscription   (Followers: 1)
Bulletin of Animal Health and Production in Africa     Full-text available via subscription   (Followers: 3)
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 1, SJR: 0.24, CiteScore: 1)
Cameroon J. of Experimental Biology     Open Access  
Central African J. of Medicine     Full-text available via subscription  
Communicate : J. of Library and Information Science     Full-text available via subscription   (Followers: 67)
Contemporary J. of African Studies     Full-text available via subscription   (Followers: 4)
Counsellor (The)     Full-text available via subscription   (Followers: 3)
Creative Artist : A J. of Theatre and Media Studies     Open Access   (Followers: 11)
Critical Studies in Teaching and Learning (CriSTaL)     Open Access   (Followers: 17)
Dar Es Salaam Medical Students' J.     Open Access  
East African J. of Public Health     Full-text available via subscription   (Followers: 4)
East African Medical J.     Full-text available via subscription   (Followers: 2, SJR: 0.122, CiteScore: 0)
East African Orthopaedic J.     Full-text available via subscription   (Followers: 1)
East and Central African J. of Pharmaceutical Sciences     Open Access   (Followers: 3)
East and Central African J. of Surgery     Open Access  
Eastern Africa Social Science Research Review     Full-text available via subscription   (Followers: 7)
Ebonyi Medical J.     Full-text available via subscription  
Egyptian J. of Biochemistry and Molecular Biology     Full-text available via subscription  
Egyptian J. of Biology     Open Access  
Egyptian J. of Natural History     Open Access   (Followers: 1)
Egyptian J. of Pediatric Allergy and Immunology     Open Access   (Followers: 2)
ESARBICA J. : J. of the Eastern and Southern Africa Regional Branch of the Intl. Council on Archives     Full-text available via subscription   (Followers: 6)
Ethiopian J. of Agricultural Sciences     Open Access  
Ethiopian J. of Biological Sciences     Open Access   (Followers: 4)
Ethiopian J. of Business and Economics     Full-text available via subscription   (Followers: 1)
Ethiopian J. of Economics     Full-text available via subscription   (Followers: 4)
Ethiopian J. of Education and Sciences     Open Access   (Followers: 6)
Ethiopian J. of Environmental Studies and Management     Open Access   (Followers: 3)
Ethiopian J. of Health Development     Open Access   (Followers: 7, SJR: 0.131, CiteScore: 0)
Ethiopian J. of Health Sciences     Open Access   (Followers: 8, SJR: 0.418, CiteScore: 1)
Ethiopian J. of Science and Technology     Open Access  
Ethiopian J. of the Social Sciences and Humanities     Full-text available via subscription   (Followers: 8, SJR: 0.101, CiteScore: 0)
Ethiopian Pharmaceutical J.     Full-text available via subscription   (Followers: 2)
Ethiopian Veterinary J.     Open Access   (Followers: 4)
Filosofia Theoretica : J. of African Philosophy, Culture and Religions     Open Access   (Followers: 1, SJR: 0.123, CiteScore: 0)
FUTY J. of the Environment     Full-text available via subscription   (Followers: 1)
Ghana J. of Agricultural Science     Full-text available via subscription   (Followers: 2)
Ghana J. of Development Studies     Full-text available via subscription   (Followers: 8)
Ghana J. of Forestry     Full-text available via subscription   (Followers: 3)
Ghana J. of Geography     Open Access   (Followers: 10)
Ghana J. of Linguistics     Open Access   (Followers: 1)
Ghana Library J.     Full-text available via subscription   (Followers: 15)
Ghana Medical J.     Open Access   (Followers: 1, SJR: 0.301, CiteScore: 1)
Ghana Mining J.     Full-text available via subscription   (Followers: 3)
Global Approaches to Extension Practice : A J. of Agricultural Extension     Full-text available via subscription   (Followers: 1)
Global J. of Agricultural Sciences     Full-text available via subscription  
Global J. of Educational Research     Full-text available via subscription   (Followers: 2)
Global J. of Engineering Research     Full-text available via subscription   (SJR: 0.109, CiteScore: 0)
Global J. of Environmental Sciences     Full-text available via subscription  
Global J. of Geological Sciences     Full-text available via subscription   (Followers: 1)
Global J. of Mathematical Sciences     Full-text available via subscription  
Global J. of Pure and Applied Sciences     Full-text available via subscription  
Global J. of Social Sciences     Full-text available via subscription   (Followers: 3)
Haramaya Law Review     Open Access   (Followers: 1)
Highland Medical Research J.     Full-text available via subscription  
Huria : J. of the Open University of Tanzania     Full-text available via subscription   (Followers: 2)
Ibadan J. of Humanistic Studies     Full-text available via subscription  
IMTU Medical J.     Full-text available via subscription  
Information Manager (The)     Open Access   (Followers: 30)
Information Technologist (The)     Full-text available via subscription   (Followers: 19)
Inkanyiso : J. of Humanities and Social Sciences     Open Access   (Followers: 1)
Internet J. of Medical Update     Open Access   (Followers: 1)
Intl. J. of Applied Agriculture and Apiculture Research     Open Access   (Followers: 3)
Intl. J. of Basic, Applied and Innovative Research     Open Access  
Intl. J. of Community Research     Open Access   (Followers: 2)
Intl. J. of Engineering, Science and Technology     Open Access  
Intl. J. of Health Research     Open Access   (Followers: 4, SJR: 0.101, CiteScore: 0)
Intl. J. of Herbs and Pharmacological Research     Open Access   (Followers: 1)
Intl. J. of Medicine and Biomedical Research     Open Access   (Followers: 1, SJR: 0.104, CiteScore: 0)
Intl. J. of Modern Anthropology     Open Access   (Followers: 2)
Intl. J. of Pedagogy, Policy and ICT in Education     Full-text available via subscription   (Followers: 3)
Italian Studies in Southern Africa : Studi d’Italianistica nell’Africa Australe     Full-text available via subscription   (Followers: 2)
J. de la Recherche Scientifique de l'Universite de Lome     Full-text available via subscription   (Followers: 2)
J. for the Study of Religion     Full-text available via subscription   (Followers: 23)
J. of Agricultural Extension     Open Access   (Followers: 2, SJR: 0.188, CiteScore: 0)
J. of Agricultural Research and Development     Full-text available via subscription  
J. of Agriculture and Food Sciences     Full-text available via subscription   (Followers: 2)
J. of Agriculture and Social Research (JASR)     Open Access   (Followers: 5)
J. of Agriculture, Forestry and the Social Sciences     Full-text available via subscription   (Followers: 5)
J. of Applied Biosciences     Open Access   (Followers: 1)
J. of Applied Science and Technology     Full-text available via subscription   (Followers: 1)
J. of Applied Sciences and Environmental Management     Open Access   (Followers: 2)
J. of Aquatic Sciences     Full-text available via subscription   (Followers: 3)
J. of Community Medicine and Primary Health Care     Open Access   (Followers: 5)
J. of Computer Science and Its Application     Full-text available via subscription   (Followers: 2)
J. of Development and Communication Studies     Open Access   (Followers: 5)
J. of Endocrinology, Metabolism and Diabetes of South Africa     Open Access   (Followers: 8, SJR: 0.174, CiteScore: 0)
J. of Environmental Extension     Full-text available via subscription  
J. of Family Ecology and Consumer Sciences :Tydskrif vir Gesinsekologie en Verbruikerswetenskappe     Open Access  
J. of Health and Visual Sciences     Full-text available via subscription   (Followers: 1)
J. of History and Diplomatic Studies     Full-text available via subscription   (Followers: 8)
J. of Language, Technology & Entrepreneurship in Africa     Open Access   (Followers: 2)
J. of Medical and Biomedical Sciences     Open Access   (Followers: 2, SJR: 0.162, CiteScore: 0)
J. of Medicine and Biomedical Research     Open Access   (Followers: 1)
J. of Meteorology and Climate Science     Full-text available via subscription   (Followers: 13)
J. of Pharmaceutical and Allied Sciences     Full-text available via subscription   (Followers: 1)
J. of Pharmacy & Bioresources     Full-text available via subscription   (Followers: 4, SJR: 0.405, CiteScore: 1)
J. of Religion and Human Relations     Open Access   (Followers: 3)
J. of Research in Forestry, Wildlife and Environment     Open Access   (Followers: 6)
J. of Research in National Development     Full-text available via subscription  
J. of Science and Sustainable Development     Full-text available via subscription  
J. of Science and Technology (Ghana)     Open Access   (Followers: 3)
J. of Social Development in Africa     Full-text available via subscription   (Followers: 8)
J. of the Ghana Science Association     Full-text available via subscription   (Followers: 3)
J. of the South African Society of Archivists     Full-text available via subscription   (Followers: 8)
J. of Tropical Microbiology and Biotechnology     Full-text available via subscription  
Jos J. of Medicine     Open Access  
KCA J. of Business Management     Open Access  
Kenya Veterinarian     Full-text available via subscription   (Followers: 2)
Kioo cha Lugha     Full-text available via subscription  
Lagos Historical Review     Full-text available via subscription  
Lagos Notes and Records     Full-text available via subscription  
Law, Democracy & Development     Open Access   (Followers: 6)
Legon J. of the Humanities     Full-text available via subscription  
Lwati : A J. of Contemporary Research     Full-text available via subscription   (Followers: 2)
Madagascar Conservation & Development     Open Access   (Followers: 3)
Makerere J. of Higher Education     Full-text available via subscription   (Followers: 2)
Malawi J. of Science and Technology     Open Access   (Followers: 6)
Marang : J. of Language and Literature     Full-text available via subscription  
Medical J. of Zambia     Open Access  
Mizan Law Review     Open Access   (Followers: 1)
Momona Ethiopian J. of Science     Open Access   (Followers: 4)
New Agenda : South African J. of Social and Economic Policy     Full-text available via subscription  
New Egyptian J. of Microbiology     Full-text available via subscription  
Nigeria Agricultural J.     Full-text available via subscription   (Followers: 2)
Nigerian Dental J.     Full-text available via subscription   (Followers: 2)
Nigerian Endocrine Practice     Full-text available via subscription  
Nigerian Food J.     Full-text available via subscription   (Followers: 2)
Nigerian Health J.     Open Access   (Followers: 1)
Nigerian Hospital Practice     Full-text available via subscription  
Nigerian J. of Animal Science     Full-text available via subscription   (Followers: 1)
Nigerian J. of Biotechnology     Open Access  
Nigerian J. of Chemical Research     Full-text available via subscription   (Followers: 2)
Nigerian J. of Clinical Medicine     Full-text available via subscription  
Nigerian J. of Family Practice     Full-text available via subscription   (Followers: 1)
Nigerian J. of Gastroenterology and Hepatology     Full-text available via subscription  
Nigerian J. of Guidance and Counselling     Full-text available via subscription   (Followers: 3)
Nigerian J. of Medicine     Full-text available via subscription  
Nigerian J. of Natural Products and Medicine     Full-text available via subscription  
Nigerian J. of Nutritional Sciences     Full-text available via subscription  
Nigerian J. of Paediatrics     Open Access   (Followers: 1)
Nigerian J. of Parasitology     Full-text available via subscription   (Followers: 1)
Nigerian J. of Physiological Sciences     Open Access   (SJR: 0.128, CiteScore: 0)
Nigerian J. of Psychiatry     Full-text available via subscription   (Followers: 3)

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Ethiopian Pharmaceutical Journal
Number of Followers: 2  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1029-5933
Published by African Journals Online Homepage  [263 journals]
  • In vivo influence of S-adenosylmethionine supplementation on ethanol
           teratogenicity in the rat
    • Authors: Girma Seyoum
      Abstract: Studies have shown that maternal alcohol consumption during pregnancy negatively impacts on prenatal development. Ethanol-induced alteration in S-adenosylmethionine (SAMe) metabolism and subsequent depletion of SAMe may be a mechanism involved in fetal ethanol effects. The aim of the present study was to determine the teratogenicity of ethanol and to investigate protective effects of SAMe. Pregnant Sprague-Dawley rats, weighing 220-250 g were used. Pregnant animals were treated from day 6 through 12 of gestation with ethanol alone (6.4% ethanol) or ethanol plus SAMe (200 mg/kg). The groups for the day-20 and day-12 experiments included: Group I (ethanol liquid diet: unrestricted-fed); Group II (isocaloric maltose-dextrin liquid diet: restricted-fed); and Group III (ethanol liquid diet + SAMe: unrestricted-fed). Embryos and fetuses were recovered on gestational day-12 or day-20, respectively, and were quantitatively and qualitatively assessed for developmental anomalies. The data on continuous variables were analyzed using paired T-Test and categorical embryonic development data were processed using Chi-Square Analysis. In the present study, prenatal growth and developmental retardations such as significantly reduced crown-rump length, anomalies of the central nervous system, the heart, limbs and the skeleton were observed in embryos and fetuses of ethanol treated rats. SAMe supplementation of the ethanol treated pregnant rats significantly improved litter weight, from 20.9 + 1.6 g to 23.6 + 0.8 g, and crown-rump length from 25.8 + 0.8 mm  to 27.6 + 0.4 mm, and decreased the incidence of resorptions from 1.9 + 0.6 to 0.5 + 0.8 in day-20 fetuses. It also significantly increased embryonic protein content from 173 + 36 μg to 251 + 29 μg and significantly improved the development of brain vesicles and closure of the posterior neuropore in day-12 embryos. The present study clearly showed that ethanol is teratogenic in vivo. SAMe supplementation of ethanol treated pregnant rats partially ameliorated the teratogenic effects of ethanol. This indicated that the observed ethanol related growth and developmental abnormalities may have been, at least partly, due to ethanol-induced SAMe deficiency. Further studies should consider extending the treatment period to the entire gestational period instead of limiting it to only the days covering the period of organogenesis.Keywords: ethanol teratogenicity, Sprague-Dawley rats, S-adenosylmethionine, embryos, fetuses
      PubDate: 2018-07-12
      Issue No: Vol. 33, No. 2 (2018)
       
  • Evaluation of the antidepressant-like activity of solvent fractions of the
           aerial parts of Hypericum revolutum (Hypericaceae) in rodent models
    • Authors: Seife Demissie, Workineh Shibeshi, Ephrem Engidawork
      Abstract: Various species of the genus Hypericum have been traditionally used for different purposes. A previous study showed that 80% methanol extract of Hypericum revolutum was active in animal model of depression. The present study was performed on solvent fractions of the crude extract as part of the effort to develop a candidate drug from the plant. The fractions (chloroform, butanol and aqueous) were prepared using liquid-liquid extraction from 80% methanol extract. Antidepressant-like activity of the fractions was investigated at various doses (100, 200 and 400 mg/kg) using a host of paradigms, including forced swim test (FST), tail suspension test (TST) and open field test (OFT). Moreover, preliminary phytochemical screening and finger printing using thin layer chromatography were undertaken. Promising antidepressant-like activity was detected with 200 mg/kg and 400 mg/kg (p < 0.05) of the butanol and chloroform fractions in the FST and TST. The doses did not, however, produce significant effect on spontaneous motor activity when assessed in OFT. The aqueous fraction was devoid any activity. The findings indicate that the higher doses of chloroform and butanol fractions possess antidepressant-like activity as evidenced by significant decrease in the duration of immobility in the two paradigms. These effects of fractions were displayed without significant effect on locomotor activity, suggesting that the antidepressant-like activity observed is not caused by a non-specific motor stimulation. In addition, the preliminary phytochemical screening indicated that the fractions contained different secondary metabolites previously reported to have antidepressant-like effects.Keywords: Hypericum revolutum, anti-depressant activity, solvent fractions, forced swimming test, tail suspension test
      PubDate: 2018-07-12
      Issue No: Vol. 33, No. 2 (2018)
       
  • Formulation and optimization of clotrimazole oromucosal emulgels
    • Authors: Mahilet Mengesha, Anteneh Belete, Tsige Gebre-Mariam
      Abstract: Clotrimazole is an antifungal agent of choice for the management of oral candidiasis. In order to improve its aqueous release and enhance its residence time at the target site of oral mucosa, emulgel formulations of clotrimazole were investigated. Different oils and Tween 80/ethanol combinations were examined as drug carrier systems and central composite design was used for the optimization of the emulgels. The optimized emulgels were characterized for their globule size, robustness, release kinetics, and the effect of storage conditions on their release profiles. All the prepared formulations showed a shear-thinning rheological behaviour indicating structural breakdown of intermolecular interaction between polymeric chains and were homogeneous with pH very close to that of normal oral cavity. The optimized formulations containing 30% Tween 80/ethanol solution (2:1 ratio), 12.4% olive oil/oleic acid combination (1:1 ratio), and 4% sodium carboxymethyl cellulose released clotrimazole in vitro with approximately zero order release kinetics as a result of polymer relaxation and erosion in the aqueous media. They also showed superior residence time and spreadability in comparison to the marketed oromucosal gels with less than 200 nm globule size and nearly the same release profile over three months of storage at real and accelerated time conditions.Keywords: clotrimazole, oromucosal emulgel, optimization, central composite design, drug release
      PubDate: 2018-07-12
      Issue No: Vol. 33, No. 2 (2018)
       
  • Anti-inflammatory, analgesic and antioxidant activities of the aerial part
           extract of Indigofera spicata Forssk
    • Authors: Helen Bitew, Tewlde Teklu, Biruk Sintayehu, Kald Beshir
      Abstract: In Ethiopian traditional medicine the aerial parts of Indigofera spicata Forssk (Fabaceae) are used to treat pain, wound and swelling. The aim of this study is to evaluate the anti-inflammatory, analgesic and antioxidant effects of the plant. The aerial part of I. spicta was collected, dried and extracted by maceration using 80% methanol. The extract obtained was first subjected to in vivo acute oral toxicity test followed by in vivo anti-inflammatory and analgesic activity studies in mice. Anti-inflammatory effect of the extract was assessed using carageenan-induced mouse paw oedema assay, while acetic acid-induced writhing and hot plate test models were used to evaluate analgesic activity. DPPH assay was also employed to measure the in vitro free radical scavenging effect of the extract. Acute oral toxicity test revealed that the LD50 of the crude extract   is greater than 2000 mg/kg. Four h after injection of carrageenan, the extract at doses of 125, 250 and 500 mg/kg resulted in maximum percentage anti-inflammatory effects of 33.7, 52.6 and 63.2%, respectively. The extract also exhibited significant central and peripheral analgesic activities at a dose of 125 mg/kg as well as moderate DPPH scavenging activity with an IC50 value of 47.13 µg/ml. Thus, the results of the present study uphold the traditional use of the plant for the treatment of wounds and pain.Keywords: Indigofera spicta, acute oral toxicity, anti-inflammatory, analgesic, antioxidant
      PubDate: 2018-07-12
      Issue No: Vol. 33, No. 2 (2018)
       
  • Concomitant use of medicinal plants and conventional medicines among adult
           patients with diabetes in Ethiopia: a cross-sectional study
    • Authors: Zelalem Tilahun, Arebu Isa Bilal, Dawit Teshome, Bruck Messele Habte, Mariamawit Yonathan Yeshak, Teferi Gedif Fenta
      Abstract: Majority of the Ethiopian population relies on medicinal plants for managing their health conditions. However, there are few studies that assessed the use of these medicinal plants especially for diabetes mellitus where the concomitant use of these remedies with modern medicines may lead to negative health consequences. The aim of this study was therefore to assess the prevalence of concomitant use of medicinal plants with conventional medicines among patients with diabetes attending treatment in five referral hospitals across five regions of the country and to identify the commonly used medicinal plants for diabetes. The study used a cross-sectional design where structured interview questionnaires and data abstraction forms were used to collect the data which was then analyzed using descriptive statistics. The findings revealed that 47.8% of the study participants had ‘ever used medicinal plants’ to treat their diabetes; of whom 74.7% reported to have co-used them with modern medicines. Of the participants who reported concomitant use, only 24.0% knew of the possible safety concern of medicinal plants or their possible interactions with modern medicines. Furthermore, only 15.7% of these participants had ever discussed their use of medicinal plants with their physicians or pharmacists. Twenty-nine plant species were listed by the study participants that were reportedly used for diabetes and related conditions. The most frequently mentioned plants were Shiferaw (Moringa stenopetala), Damakase (Ocimum lamiifolium), Nech-Shinkurt (Allium sativum), Tenadam (Ruta chalapensis), Abish (Trigonella foenum-graecum), Tosign (Thymus schimperi), Tikur-Azimud (Nigella sativa), and Haregresa (Zheneria scabra). The overall findings are indicative of the need to educate patients and providers about the potential implications of the concomitant use of medicinal plants with modern medicines, and the need for further research to establish the potential interactions of some of these medicinal plants with limited or no reported data.Keywords: medicinal plants, modern medicine, diabetes mellitus, cross-sectional study, Ethiopia
      PubDate: 2018-07-12
      Issue No: Vol. 33, No. 2 (2018)
       
  • Short Communication: Chemical composition and preliminary psychostimulant
           activity of essential oil of Rosmarinus officinalis L.
    • Authors: Eyael Tewelde, Peter Lindemann, Kaleab Asres
      Abstract: The essential oil of Rosmarinus officinalis L. (family Lamiaceae) is known to produce pharmacological effects on animal behavior similar to the effects of CNS acting drugs. The objective of this study was to evaluate the chemical composition and psychostimulant properties of the oil extracted from the leaves of locally grown plants. The oil was extracted by hydrodistillation (0.82% v/w) and analyzed by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC/MS). The psychostimulant activity of the oil was evaluated in mice using sleeping time, open field test and tail suspension test models. Thirty-one compounds that accounted for 99.67% of the total oil were identified, 1,8 cineole (43.3%), α-pinene (19.34%) and camphor (8.89%) figuring as major compounds. The oil showed psychostimulant activity as indicated by a significant (p < 0.001) delay in the onset and duration of sleep and enhancement in mobility of mice. Furthermore, the tail suspension test supported the above results. The psychostimulant properties of the oil indicate its potential for the management of conditions requiring stimulants.Keywords: Rosmarinus officinalis, essential oil, gas chromatography-mass spectrometry 1,8 cineole, psychostimulant activity
      PubDate: 2018-07-12
      Issue No: Vol. 33, No. 2 (2018)
       
  • Repellent activity of essential oil of the stem of Kleinia squarrosa
           against mosquitoes
    • Authors: Mulugeta Guta, Frehiwot Teka, Daniel Bisrat, Peter Lindemann, Kaleab Asres
      Abstract: Most commercially available repellents of mosquitoes and other biting arthropods are synthetic and  have a severe toxic effect to human. Moreover, these chemicals cause an irreversible damage to the ecosystem as some of them are non-degradable in nature. Therefore, there is a need to develop safe and effective alternatives to the currently available chemicals used to control vectors. In southern Ethiopia, the smoke obtained from burning the stem of Kleinia squarrosa Cufod. is used as a fumigant to ward off mosquitoes. In the present study hydrodistillation of the powdered stem of K. squarrosa gave a pale yellow oil (0.04%; w/w) with a characteristic pungent odor. A total of twenty-seven compounds have been identified by GC-MS analysis, accounting 48.71% of the total oil. The main constituents of the oil were (E)-iso-γ-bisabolene (9%), α-pinene (5.74%), caryophyllene (5.36%) and sabinene (5.55%). The powdered stem of K. squarrosa was also burned, and the smoke extracted to yield a trace amount brownish oil. Analysis of the oil by GC-MS afforded 36 compounds comprising 94.56% of the total peak area. Terpene-4-ol (18.09%), (E)-iso-γ-bisabolene (14.07%), 5-epi-7-epi-α-eudesmol (12.45%), and caryophyllene (8.35%) figured as major compounds. Mosquito repellent activity of the essential oil was tested on guinea pigs against Anopheles gambiae by a modified Kunming mice technique under laboratory testing conditions. The essential oil exhibited a dose-dependent repellent action in the dose range tested (0.03 - 5%; v/v) with ED50 and ED99.9 values of 1.49% and 4.74% (v/v), respectively. The study further revealed that that the essential oil possesses a 3 h complete protection time. The similarity in the chemical profiles of the essential oil and the oil extracted from the smoke obtained by burning K. squarrosa stem supports the traditional use of the plant as a fumigant to kill mosquitoes.Keywords: Kleinia squarrosa; fumigant; essential oil; mosquito repellent; Anopheles gambiae
      PubDate: 2018-07-11
      Issue No: Vol. 33, No. 2 (2018)
       
 
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