Epidemiology Research International
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Open Access journal
ISSN (Print) 2090-2972 - ISSN (Online) 2090-2980
Published by Hindawi [333 journals]
- Mathematical Analysis of Malaria-Schistosomiasis Coinfection Model
Abstract: We formulated and analysed a mathematical model to explore the cointeraction between malaria and schistosomiasis. Qualitative and comprehensive mathematical techniques have been applied to analyse the model. The local stability of the disease-free and endemic equilibrium was analysed, respectively. However, the main theorem shows that if , then the disease-free equilibrium is locally asymptotically stable and the phase will vanish out of the host and if , a unique endemic equilibrium is also locally asymptotically stable and the disease persists at the endemic steady state. The impact of schistosomiasis and its treatment on malaria dynamics is also investigated. Numerical simulations using a set of reasonable parameter values show that the two epidemics coexist whenever their reproduction numbers exceed unity. Further, results of the full malaria-schistosomiasis model also suggest that an increase in the number of individuals infected with schistosomiasis in the presence of treatment results in a decrease in malaria cases. Sensitivity analysis was further carried out to investigate the influence of the model parameters on the transmission and spread of malaria-schistosomiasis coinfection. Numerical simulations were carried out to confirm our theoretical findings.
PubDate: Wed, 23 Nov 2016 13:23:27 +000
- Vernal Keratoconjunctivitis in Public Primary School Children in Nigeria:
Prevalence and Nomenclature
Abstract: Objective. This study sought to add to the body of information on the prevalence and pattern of vernal keratoconjunctivitis (VKC) among school aged children in Cross River State, Nigeria. Method. A cross-sectional survey of children in public primary schools in Cross River State, Nigeria, was studied for VKC. Five schools were included, using a multistage sampling technique. Comprehensive eye examinations were conducted in one thousand two hundred and twenty-six (1226) school children. Main Outcome Measures/Results. The mean age of the population of 1226 school attending children was . The prevalence of VKC was 18.1% in this population study. The ratio of males to females is 1.8 : 1. The clinical grading of the 223 children with VKC is as follows: 43 (19.3%) quiescent, 134 (60.1%) mild, 44 (19.7%) moderate, and 2 (0.9%) severe VKC. The clinical types reported are as follows: limbal 67 (30.0%), tarsal 105 (47.1%), and mixed 51 (22.9%). The clinical types were used to describe a modified nomenclature. Conclusions. Vernal keratoconjunctivitis is a commonly occurring chronic condition and an important public health problem. A simple diagnostic nomenclature for describing VKC for primary health care workers is recommended.
PubDate: Mon, 18 Jul 2016 17:27:39 +000
- WHO European Childhood Obesity Surveillance Initiative: Impact of Type of
Clothing Worn during Anthropometric Measurements and Timing of the Survey
Abstract: Background. The World Health Organization European Childhood Obesity Surveillance Initiative (COSI) conducted examinations in 6–9-year-old children from 16 countries in the first two rounds of data collection. Allowing participating countries to adhere to their local legal requirements or adapt to other circumstances required developing a flexible protocol for anthropometric procedures. Objectives. (1) Review intercountry variation in types of clothing worn by children during weight and height measurements, clothes weight adjustments applied, timing of the survey, and duration of data collection; (2) assess the impact of the observed variation in these practices on the children’s weight or body mass index (BMI) outcome measures. Results. The relative difference between countries’ unadjusted and clothes-adjusted prevalence estimates for overweight was 0.3–11.5%; this figure was 1.4–33.3% for BMI-for-age Z-score values. Monthly fluctuations in mean BMI-for-age Z-score values did not show a systematic seasonal effect. The majority of the monthly BMI-for-age Z-score values did not differ statistically within a country; only 1–3 monthly values were statistically different within some countries. Conclusions. The findings of the present study suggest that the built-in flexibility in the COSI protocol concerning the data collection practices addressed in the paper can be kept and thus do not necessitate a revision of the COSI protocol.
PubDate: Wed, 27 Apr 2016 06:42:09 +000
- Association of Breastfeeding and the Federal Poverty Level: National
Survey of Family Growth, 2011–2013
Abstract: Breastfeeding is strongly endorsed in the Healthy People 2020 goals; however, there remain many disparities in breastfeeding prevalence. The purpose of this study was to examine the association between breastfeeding and the Federal Poverty Level in the United States. Data from 5,397 women in the National Survey of Family Growth 2011–2013 survey were included in this study. The data were analyzed for descriptive features and logistic regressions of the Federal Poverty Level on breastfeeding. There were 64.1% of women who reported breastfeeding. Over one-third (35.2%) of women reported having a household income of 0–99% of the Federal Poverty Level. There were 15.2% of women who reported an income of 400% and above the Federal Poverty Level. With statistical adjustment for maternal age, race/ethnicity, education, marital status, parity, preterm birth, birth weight, insurance, and dwelling, the Federal Poverty Level was not significantly associated with breastfeeding. In this recent survey of mothers, Federal Poverty Level was not shown to be a significant factor in breastfeeding.
PubDate: Thu, 03 Mar 2016 15:12:10 +000
- Hip Fracture-Related Mortality among Older Adults in the United States:
Analysis of the CDC WONDER Multiple Cause of Death Data, 1999–2013
Abstract: Objectives. To examine trends in hip fracture-related mortality among older adults in the United States between 1999 and 2013. Material and Methods. The Wide-Ranging Online Data for Epidemiological Research system was used to identify adults aged 65 years and older with a diagnosis of hip fracture reported in their multiple cause of death record. Joinpoint regression analyses were performed to estimate the average annual percent change in hip fracture-related mortality rates by selected characteristics. Results. A total of 204,254 older decedents listed a diagnosis of hip fracture on their death record. After age adjustment, hip fracture mortality rates decreased by −2.3% (95% CI, −2.7%, and −1.8%) in men and −1.5% (95% CI, −1.9%, and −1.1%) in women. Similarly, the proportion of in-hospital hip fracture deaths decreased annually by −2.1% (95% CI, −2.6%, and −1.5%). Of relevance, the proportion of cardiovascular diseases reported as the underlying cause of death decreased on average by −4.8% (95% CI, −5.5%, and −4.1%). Conclusions. Hip fracture-related mortality decreased among older adults in the United States. Downward trends in hip fracture-related mortality were predominantly attributed to decreased deaths among men and during hospitalization. Moreover, improvements in survival of hip fracture patients with greater number of comorbidities may have accounted for the present findings.
PubDate: Mon, 29 Feb 2016 09:51:55 +000
- High Tuberculosis Disease Burden among Indigenous People of the Paraguayan
Chaco and Associated Community Characteristics, 2002–2004: An Ecological
Abstract: Indigenous populations are generally reported to suffer greater active tuberculosis (TB) disease burden. The objective of this study was to examine ecological associations between cases of active adult and pediatric TB reported from 2002 to 2004 and community characteristics in indigenous communities of the Paraguayan Chaco. Adult and pediatric models were examined by negative binomial and Poisson GLM regression, respectively. Active TB prevalence in indigenous people was eight times higher than the nonindigenous population. Communities with a health post were more than twice as likely to report active adult TB (RR = 2.07, 95% confidence interval (CI) [1.14–3.83], and ). Each additional average year of education in the community was associated with nearly 50% less likelihood of active pediatric TB (RR = 0.53, 95% CI [0.38–0.73], and ). Although nonsignificant, the presence of nonindigenous community members had a strong protective association in both the adult (RR = 0.56, 95% CI [0.30–1.03], and ) and pediatric models (RR = 0.64, 95% CI [0.34–1.14], and ). These results reinforce the importance of increasing epidemiologic surveillance and investigating the social determinants of TB disease among vulnerable indigenous populations.
PubDate: Sun, 20 Dec 2015 08:35:09 +000
- Workplace Violence: A Survey of Nationally Registered Emergency Medical
Abstract: Previous studies on violence against prehospital personnel have mainly reported on “verbal” and “physical” violence. This study explored how provider demographic and work-related characteristics were associated with five different forms of workplace violence (being cursed or threatened; being punched, slapped, or scratched; being spat upon; being stabbed/stabbing attempt; and being shot/shooting attempt). A cohort of nationally registered United States Emergency Medical Services professionals was surveyed to determine the experience of each of these types of patient initiated violence by these providers and their partners. Multivariable logistic regression analyses indicated gender was significantly associated with both being cursed/threatened and being stabbed or experiencing a stabbing attempt (odds ratio (OR) = 0.65, CI = 0.44–0.96; OR = 0.27, CI = 0.09–0.75, resp.). Level of EMT practice was significantly associated with being cursed/threatened, being spat upon, and being punched, slapped, or scratched (OR = 0.17, CI = 0.11–0.27; OR = 0.30, CI = 0.21–0.43; OR = 0.31, CI = 0.22–0.44, resp.). Both community size and experience were significantly associated with all the types of violence investigated. EMS workplace violence research is at its infancy; thus this study adds to a limited but growing body of knowledge.
PubDate: Thu, 28 May 2015 11:06:15 +000
- Risk Factors for Infection with Soil Transmitted Helminths,
Cryptosporidium spp., and Giardia duodenalis in Children Enrolled in
Preschools in Kafue District, Zambia
Abstract: Intestinal parasitic infections are common among children worldwide. This study was aimed at determining risk factors for infection with soil transmitted helminths, Cryptosporidium spp., and Giardia duodenalis, among children in preschools. The study was in two parts: a cross-sectional study in which data were collected from 403 children from 10 preschools and a longitudinal study in which 100 children from four preschools from the previous 10 were selected. Prevalence of Ascaris lumbricoides was 12.0%, while that of hookworm was 8.3%. Overall prevalence of Cryptosporidium and G. duodenalis was 28.0% and 29.0%, respectively. Low education level of parent/guardian was a significant risk factor for A. lumbricoides (OR = 2.35, 95% CI: 1.02–5.41; ), while roofing types other than corrugated iron sheets were found to be protective for G. duodenalis infection in both bivariate and multivariate analyses (multivariate: OR = 0.67, 95% CI: 0.45–0.99; ). Low socioeconomic level was found to be protective for Cryptosporidium spp. infection in multivariate analysis (OR = 0.59, 95% CI: 0.35–0.99; ). In the longitudinal study, none of the factors were associated with either infection. These findings may have implications for other preschools in other districts in Zambia.
PubDate: Wed, 01 Apr 2015 06:58:09 +000
- The Time of the Insult/Triggering Event in Primary Osteosarcoma and
Ewing’s Sarcoma of Bone as Determined by Incubation Period Modeling and
Age Distribution of Such Malignancies
Abstract: The time for the triggering event in neoplasms can be estimated using incubation period modeling techniques. We applied these techniques to primary osteosarcoma and Ewing’s sarcoma of bone using the Surveillance Epidemiology and End Results database for all cases of osteosarcoma or Ewing’s sarcoma of bone from 1993 through 2010. Secondary neoplasms were excluded. The age at diagnosis, gender, ethnicity, and anatomic location were collected. The time () of the insult/triggering event was calculated using the best fit frequency distribution of age at diagnosis. There were 4,356 patients with osteosarcoma and 1,832 patients with Ewing’s sarcoma. The Pearson IV distribution was the best fit for both osteosarcoma () and Ewing’s sarcoma (). For these distributions is −0.7 years of age (4 weeks after conception) for Ewing’s sarcoma, 0.45 years for long bone osteosarcoma, and 10.4 years for parosteal osteosarcoma. This confirms the genetic etiology of Ewing’s sarcoma since an is 4 weeks after conception. Long bone osteosarcoma is not entirely genetic, as was 0.4 years for conventional osteosarcoma and 10.4 years for parosteal osteosarcoma. The etiologies for those two different types of osteosarcoma are thus different.
PubDate: Wed, 11 Mar 2015 10:49:43 +000
- Distribution of Human Leishmaniasis (VL) and Its Associated Risk Factors,
in Metemma, Ethiopia
Abstract: Background. Leishmaniasis is a parasitic disease caused by obligate intracellular protozoans of the genus Leishmania. Objective. To assess the distribution of human leishmaniasis and assess community knowledge, attitude, and practice with regard to assumed risk factors and control options used by the society. Methods. Retrospective study from November 2013 to May 2014 was used. Six-year data from Metemma hospital record was reviewed and 89 people were interviewed. Results. The rates were 29% (n = 374/1270) and 26% (n = 328/1270) in 2005 E.C and 2003 E.C, respectively. 94% (1194/1270) of the affected individuals were in the age exceeding 15 years. At the same time, the rates in males and female were 97% (n = 1226/1270) and 3% (n = 44/1270), respectively. According to 88.8% (n = 79/89) of the respondents, transmission occurs through bite of sandflies, while 98.9% (n = 88/89) of the respondent’s indicated that waste disposal in an open space was one of the risk factors for disease occurrence. Regarding the control measures, respondents replied that 73% (n = 65/89) of them use impregnated bed net and others use cleaning and proper waste disposal. Conclusion. The current finding indicated that the disease was common in the study area; as a result, proper use of impregnated bed net, early diagnosis and treatment, and reduction of different risk factors were essential.
PubDate: Sun, 22 Feb 2015 10:07:16 +000
- Quality Assessment of 25(OH)D, Insulin, Total Cholesterol, Triglycerides,
and Potassium in 40-Year-Old Frozen Serum
Abstract: Background. Many longitudinal epidemiological studies collect specimens into biobanks to investigate how biomarkers predict future disease. In 1968-1969, the Population Study of Women in Gothenburg (PSWG) established a biobank of serum samples. Objective. To examine the validity of 25-hydroxyvitamin D (25(OH)D), total cholesterol, triglycerides, insulin, and potassium after 40 years of storage at −20°C in terms of relative and absolute agreement. The quality of these markers under such condition has not been previously investigated. Methods. Baseline and remeasured levels were compared in selected samples through percentage change, correlation, and regression. 25(OH)D levels, not assessed at baseline, were compared by season, by BMI, and longitudinally over six years. Results. Despite some lack of absolute agreement, Spearman correlations were >0.7 and statistically significant for all biomarkers. The 1968-1969 25(OH)D correlated with BMI and with levels six years later . Summer 25(OH)D was higher than winter 25(OH)D . Conclusion. For all markers, baseline and remeasured levels exhibited high relative agreement. 25(OH)D was comparable with expected levels on fresh blood and varied with season. In future studies, PSWG individuals will be ranked according to these markers in order to predict incidence of disease.
PubDate: Sun, 15 Feb 2015 12:15:45 +000
- Radiation May Indirectly Impair Growth Resulting in Reduced Standing
Height via Subclinical Inflammation in Atomic-Bomb Survivors Exposed at
Abstract: For young atomic-bomb (A-bomb) survivors, A-bomb radiation’s (total) effect on standing height is thought to comprise the sum of direct effect and indirect effect via inflammation. With the data of five inflammatory markers—white blood cell count, sialic acid, corrected erythrocyte sedimentation rate (ESR), 1 globulin, and 2 globulin—obtained in adulthood during the period 1988 to 1992, a summary inflammatory index was constructed as a surrogate for the five subclinical inflammatory markers. For 3,327 A-bomb survivors exposed at ages of less than 25 years, a structural equation model was analyzed to measure direct radiation effects on adult height as well as mediating effect of radiation via inflammation on the height after adjustment for other risk factors, smoking, cancer, inflammatory disease, obesity, and diabetes mellitus. The mediation proportion of the radiation effect on height via inflammation was approximately 5% for both sexes for all ages, and indirect dose effects via inflammation were statistically significant for both sexes combined and for females exposed at ages 0 to 5 years. Indirect dose effects for all ages via sialic acid, corrected ESR, and 2 globulin were marginally significant for both sexes combined and for females. These proportions are likely underestimated.
PubDate: Mon, 02 Feb 2015 09:06:41 +000
- Optimal Waist Circumference Cut-Off Point for Multiple Risk Factor
Aggregation: Results from the Maracaibo City Metabolic Syndrome Prevalence
Abstract: Context and Objective. The purpose of this study was to determine optimal waist circumference (WC) cut-off values for the detection of multiple risk factor aggregation in individuals from Maracaibo, Venezuela. Participants and Methods. A total of 1,902 adult individuals of both genders belonging to MMSPS were included. Complete physical, laboratory, and anthropometric examination were done to evaluate Metabolic Syndrome (MS) components and insulin resistance. ROC curves were plotted for risk factor aggregation in order to assess WC cut-off point. Logistic regression models were constructed to assess risk factors associated with the WC. Results. There were 52.2% females and 47.8% males, with WC of cm and cm, respectively. ROC curves exhibited a WC cut-off point for women of 90.25 cm (68.4% sensitivity, 65.8% specificity) and 95.15 cm (71.1% sensitivity, 67.4% specificity) for men. HOMA2-IR and high blood pressure were associated with a WC over these cut-off points, as well as 2.5-fold risk increase for multiple risk factor aggregation (OR 2.56; CI 95%: 2.05–3.20; ). Conclusions. These population-specific WC cut-offs are readily applicable tools for detection of risk factor aggregation. Insulin resistance is closely associated with this definition of abdominal obesity, which may serve as a surrogate for its assessment.
PubDate: Tue, 09 Dec 2014 09:53:24 +000
- Blindness Registers as Epidemiological Tools for Public Health Planning: A
Case Study in Belize
Abstract: For public eye health programs, blindness registers can be an important tool for informing service planning. This study examines how the Belize Council for the Visually Impaired (BCVI) used its blindness register data to drive several public health interventions. Cross-sectional analysis was performed for all active registrants () to determine the distribution of causes of registration according to age, sex, and geographical district. Cataract was the leading cause of registration (39.6%), followed by glaucoma (20.8%), diabetic retinopathy (10.2%), and childhood blindness (9.4%). The distribution of the causes of registration was fairly similar between men and women and across the various districts. However, in Stann Creek, whose population is largely of African descent, glaucoma exceeded cataract. For most causes, the majority of registrants were registered at age 50 or older. Follow-up was conducted four years later. Several interventions had been initiated, most notably bolstering cataract surgical services and creating screening programs for glaucoma and diabetic retinopathy. The register itself was also improved to maximize its utility for future use. While standardized surveys may be the most appropriate method of estimating population-based measures such as prevalence or incidence, the blindness register is still a valuable source of data for public health planning.
PubDate: Wed, 03 Dec 2014 13:24:29 +000
- The Correlation between Gender Inequalities and Their Health Related
Factors in World Countries: A Global Cross-Sectional Study
Abstract: The study aimed to investigate gender inequalities and their health associated factors in world countries. A cross-sectional survey was undertaken using data of United Nations Development Programme (UNDP) and World Health Organization (WHO). The main variable in this study was gender inequality index (GII). All countries were stratified by WHO regions. Pearson correlation coefficient was used to assess the linear correlation between GII and investigated factors by WHO regions. The mean of GII was greater in Africa and lower in Europe region. There was negative significant association between GII and life expectancy at birth and mean years of schooling, prevalence of current tobacco smoking, high blood pressure and overweight and obesity, alcohol consumption rate, and cancer death rate. But there was positive significant association between GII and noncommunicable diseases death rates. In conclusion, gender inequalities, though decreasing over the past decades in world, remain notably greater in Africa and Eastern Mediterranean regions than in Europe. Gender inequality is also an important issue which is related to health factors. Hence, countries will need to focus on public health intervention and equal distribution of economic resources to reduce gender inequality in society.
PubDate: Sun, 09 Nov 2014 08:05:22 +000
- The Infection Hypothesis Revisited: Oral Infection and Cardiovascular
Abstract: Background. The pathophysiology of cardiovascular disease (CVD) includes inflammation in the development of atherosclerosis and thrombosis. Increasing evidence supports oral infections, and in particular the common periodontal disease, to be associated with CVD development. Periodontal infection is present in populations worldwide and in the moderate to mild form in about 35% of populations according to the World Health Organization. Objective. This review of the literature aims to present cross evidence from medical research disciplines that explore how oral infections can contribute to increase the risk for CVDs and how treatment of oral infections can reduce the risk for CVDs. Design. Review article. Results. Long-term exposure to active nontreated infections of the oral cavity presents an opportunity for bacteria, bacterial products, and viruses to enter the circulation. Toxic bacterial products enter the circulation, affecting atherosclerosis, causing platelet adhesiveness that results in clot formation, and establishing cardiac vegetation. Pathological observations have identified oral bacteria in heart valves, aortic aneurysms, and arterial walls. Clinical intervention studies on periodontal disease reduce the risk level of serological predictors for CVDs. Conclusions. This paper presents evidence across medical research disciplines for oral infections to be considered as one of the risk factors for CVDs.
PubDate: Tue, 21 Oct 2014 11:24:52 +000
- Eye Diseases among Women Engaged in Local Extraction of Palm Kernel Oil in
the Kumasi Metropolis
Abstract: The study aimed to determine the prevalence of eye diseases among women engaged in the local extraction of palm kernel oil in the Kumasi Metropolis. A cross-sectional study was carried out in five women groups purposively sampled. A total of 150 women were sampled. History taken from the women included participants’ demographics and ocular and occupational history. Ocular examination included visual acuity and ophthalmoscopy. The Statistical Package for Social Sciences (SPSS) version 17.0 was used to analyze the data. Descriptive statistics and Chi-square test were employed. A total of 150 women aged from 17 to 84 years were examined. The prevalence of eye diseases was 56.0%. The ocular disease with the highest prevalence was pterygium (34.0%), followed by cataract and pinguecula (20.0% each). The study revealed a high ocular morbidity rate. Regular eye examination and education are recommended for these women since they are exposed to several risk factors which play important roles in ocular morbidities.
PubDate: Mon, 13 Oct 2014 11:32:18 +000
- Breast Cancer in Young Brazilian Women: Challenge for the Oncology Care
Abstract: Objective. To investigate and compare aspects of breast cancer in young women (40 years old). Methods. Retrospective, cross-sectional, analytical, and exploratory study based on data from 2009 to 2012 obtained from the Breast Cancer Information System (SISMAMA) and the Unified Health System Information Data (DATASUS). The studied population consisted of women () with malignant breast cancer. The analysed variables were education level, race, nodule detection at the clinical examination or image studies, presence of palpable axillary lymph nodes, surgical approach, and tumor histological type and grade. Results. There was increasing detection of breast cancer cases in young women among the studied years. Young women had more palpable lymph nodes (OR 1.28, 95% CI: 1.18–1.39), ductal carcinoma as the most frequent histologic type (OR 1.36, 95% CI: 1.22 to 1.53), and grades II and III tumor (OR 16.01 , 95% CI: 13.30 to 19.28 ). The lesion detection by clinical examination was higher in women
PubDate: Tue, 27 May 2014 07:23:50 +000
- Determinants of Bone Strength Estimated by Calcaneal Ultrasonography in
Inuit Women from Nuuk (Greenland)
Abstract: This study was conducted to identify determinants of bone strength estimated by quantitative ultrasonography (QUS) at the calcaneus of Greenlandic Inuit women. A total of 153 Inuit women from Nuuk, aged from 49 to 64 years, participated in the first QUS measurement (year 2000) with an Achilles Lunar instrument (speed of sound (SOS); broadband ultrasound attenuation (BUA); stiffness index (SI)). A second measurement was performed two years later (year 2002) in 121 participants. Several factors known to be associated with bone strength were recorded at baseline for 118 of them. Determinants of QUS parameters were identified using an automatic (stepwise) selection of variables in linear regression. Significant determinants of baseline QUS measurements were age and body weight for all QUS parameters, height for BUA and SI, and hormone replacement therapy (HRT) use for SI. Significant predictors of follow-up QUS measurements were baseline QUS values, the smoking status and HRT use for all QUS parameters, omega-3/omega-6 PUFA content ratio of erythrocytes membrane phospholipids (BUA and SI), and menopausal status (BUA). Several modifiable dietary factors, such as a diet rich in omega-3 PUFAs and lifestyle factors (i.e., smoking, taking HRT), were shown to determine QUS parameters after a follow-up of two years.
PubDate: Thu, 27 Mar 2014 00:00:00 +000
- Do Demographic Profiles of Listed and Unlisted Households Differ'
Results of a Nationwide Telephone Survey
Abstract: A growing number of households are not reachable through traditional directory-based samples, which can have important implications for the representativeness of telephone surveys. The current study aims to investigate the demographic differences between households which have their telephone numbers listed or not listed in the Australian White Pages telephone directory. A total of 5,023 eligible Australian residents who were currently in paid employment participated in this study. Each respondent’s telephone number was individually matched to the residential White Pages to determine its listed status, and demographic variables were compared between those with a listed and unlisted telephone number. Those with an unlisted number were significantly more likely to be younger, to have been born in a country outside of Australia, and to live in a lower socioeconomic area than those who were listed in the White Pages. These demographic differences should be considered when undertaking telephone surveys using a White Pages sample.
PubDate: Tue, 18 Mar 2014 12:04:14 +000
- Factors Associated with a Poor Treatment Outcome among Children Treated
for Malaria in Ibadan, Southwest Nigeria
Abstract: We present data on factors associated with poor treatment outcome (death or recovery with a neurological complication) among children treated for malaria in Ibadan, Nigeria. A total of 2468 children (1532 with uncomplicated and 936 with severe malaria) were recruited from three government facilities. History was obtained from caregivers and malarial parasite test was carried out on each child. About 76.0% of caregivers had instituted home treatment. Following treatment, 2207 (89.5%) children recovered without complications, 9.1% recovered with neurological complications, and 1.4% died. The possibility of poor treatment outcome increased with decreasing child’s age (). A statistically significant proportion of children with pallor, jaundice, hepatomegaly, splenomegaly, respiratory distress, and severe anaemia had poor treatment outcome. Following logistic regression, child’s age < 12 months compared to older age groups (O.R = 5.99, 95% C.I = 1.15–31.15, and ) and loss of consciousness (O.R = 4.55, 95% CI = 1.72–12.08, and ) was significantly associated with poor treatment outcome. We recommend interventions to improve caregivers’ awareness on the importance of seeking medical care early. This will enhance early diagnosis and treatment and reduce the likelihood of complications that lead to poor treatment outcomes.
PubDate: Wed, 26 Feb 2014 12:13:34 +000
- The Mississippi Delta Cardiovascular Health Examination Survey: Study
Design and Methods
Abstract: Assessment of cardiovascular disease (CVD) morbidity and mortality in subnational areas is limited. A model for regional CVD surveillance is needed, particularly among vulnerable populations underrepresented in current monitoring systems. The Mississippi Delta Cardiovascular Health Examination Survey (CHES) is a population-based, cross-sectional study on a representative sample of adults living in the 18-county Mississippi Delta region, a rural, impoverished area with high rates of poor health outcomes and marked health disparities. The primary objectives of Delta CHES are to (1) determine the prevalence and distribution of CVD and CVD risk factors using self-reported and directly measured health metrics and (2) to assess environmental perceptions and existing policies that support or deter healthy choices. An address-based sampling frame is used for household enumeration and participant recruitment and an in-home data collection model is used to collect survey data, anthropometric measures, and blood samples from participants. Data from all sources will be merged into one analytic dataset and sample weights developed to ensure data are representative of the Mississippi Delta region adult population. Information gathered will be used to assess the burden of CVD and guide the development, implementation, and evaluation of cardiovascular health promotion and risk factor control strategies.
PubDate: Thu, 13 Feb 2014 14:05:11 +000
- Foodborne Infections and Intoxications in Hyderabad India
Abstract: Foodborne diseases are one of the health hazards and causes of morbidity and mortality in developing countries. In India there are no systematic studies to understand the types of foods involved and the etiological agent causing the disease. Therefore, a pilot study was proposed to investigate the food poisoning cases, undertaken by the Ronald Ross Institute of Tropical Diseases, which is a referral hospital for foodborne diseases in Hyderabad. Food and stool/rectal swabs of the patients affected were collected for microbiological examination. Odds ratio and 95% confidence interval were used to express the statistical significance of the differences. Epidemiological, environmental, and laboratory components indicated that Staphylococcus aureus was the etiological agent in most of the cases and in one case Salmonella spp. were the main cause of food poisoning. This study indicated the need to take up foodborne disease surveillance under the Indian context and to identify the common high-risk food commodities for microbial contamination and identification.
PubDate: Thu, 13 Feb 2014 13:57:32 +000
- Epidemiological Patterns of Varicella in the Period of 1977 to 2012 in the
Rijeka District, Croatia
Abstract: The incidence and distribution of reported varicella cases in the Rijeka District (RD), Croatia (323,130 inhabitants in 1990 and because of the new administrative distribution 305,505 inhabitants in 1991), from 1977 to 2012 are presented. During this period, varicella is continuously present in the RD and these epidemics appear practically every other year. The highest incidence of 1642 per 100,000 inhabitants was registered in 1987. High incidence was also registered during the interepidemic years, while the lowest 247 per 100,000 inhabitants was registered in 2001. Children between the ages of 5 and 9 years were mostly infected, while 87.7% of the 78,883 registered cases were in those up to 14 years. Varicella manifests most intensively during winter and spring, with a peak in March and April. Males are not significantly more affected (51.1%) than females (48.9%). In the observed period, there was not a single reported case of death connected with the varicella disease.
PubDate: Wed, 29 Jan 2014 13:33:46 +000
- Assessment of the Knowledge of Poultry Farmers and Live Poultry
to Preventive and Control Measures on Bird Flu, Benin City, Nigeria
Abstract: Investigated was the knowledge of preventive measures of avian influenza from farmers, live chicken sellers, and poultry veterinarian in Benin City, Edo State, Nigeria. A cross-sectional descriptive study using standardized questionnaire was conducted. Respondents included 236 poultry farmers, live chicken sellers (LCS), and veterinarian aged 12–70 years in contact with birds through husbandry. The study duration was from October 2010 to May 2011. Participants knowledge on transmission sources showed low understanding with highest being from bird-bird (57.3%). The medium most commonly utilized was electronic media (82.5%) as information source. Respondents thought that vaccination of birds (80.6%) would prevent infection. Farmers’ education on bird flu needs to be improved through veterinary public health and health promotion approach. Nonpharmaceutical preventive measures such as hand washing freely and avoidance of eye, nose, and mouth touching must be improved.
PubDate: Sun, 19 Jan 2014 13:05:45 +000
- Sociodemographic Characteristics of Acne among University Students in
Abstract: To estimate the prevalence and identify risk factors that may be associated with acne among university students in Syria, a cross-sectional study was conducted in the Syrian International University for Science and Technology in December 2009. A sample of 500 students was chosen. Each participant was subjected to an interview and clinical examination of acne in addition to height and weight measurements. Acne prevalence was 34.7% (172/496). Male students had higher rate of acne compared to females (42.9% versus 23.6%, ) and their acne started significantly at a younger age (18.13 versus 19.04 years old, ). Face was the commonest site for acne in both males and females. Washing face frequently per day in both sexes has a significant relation with a decreased prevalence of acne. Moreover, psychological stress particularly when the students were away from family was associated with a significant higher rate of acne. We found that the prevalence of acne steadily increased with increasing body mass index. Acne is a health and psychological problem among university students particularly when affecting the face. Several factors such as gender, body mass index, and stress were found to be associated with acne formation.
PubDate: Thu, 02 Jan 2014 13:28:26 +000
- Validation of the ISAAC Standardized Questionnaire Used by Schoolchildren
from Mexicali, Baja California, Mexico
Abstract: Background. In Mexico, several studies have been conducted under the ISAAC methodology; nevertheless, no validation studies of the ISAAC questionnaire based on objective clinical testing in our country have been published. Aims of the Study. To validate the ISAAC questionnaire, used in a study of prevalence of allergic diseases, based on medical, respiratory, and allergic evaluations of schoolchildren being 11 to 16 years old in Mexicali, Mexico. Material and Methods. We conducted a cross-sectional study to validate the ISAAC questionnaire through the generation of an index (considered as gold standard) using pre- and postbronchodilator spirometry test, exhaled nitric oxide measurements, and atopic evaluations. 114 schoolchildren were included (23 asthmatics with respiratory symptoms and 91 nonasthmatics without respiratory symptoms) and we evaluated the sensitivity, specificity, and positive and negative predictive value of the questionnaire using discriminant analysis. Results. We observed sensitivity of 35.2% and specificity of 93.3% and the positive and negative predictive values were 82.6% and 61.5%, respectively. Conclusions. Our findings indicate that the ISAAC Mexican version questionnaire was less sensitive and more specific when compared to the gold standard; however, it is adequate and able to discriminate children with and without asthma and a useful tool to use in epidemiological studies.
PubDate: Wed, 25 Dec 2013 10:17:55 +000
- Benfluorex and Mortality: A Fresh Perspective
Abstract: Benfluorex, a drug related to fenfluramine, has been sold under the trade name “Mediator” by Servier Laboratories and was introduced to the French market in 1976, licenced for the treatment of type 2 diabetes and dyslipidemia. Although the evidence that benfluorex increases the risk of mild valvular regurgitant abnormalities is convincing, it is also apparent that no data exist from which to calculate the risk of death attributable to benfluorex use. Despite this, two studies have attempted to make such estimates, the results of which have been the focus of much media attention. In this review, we attempt to provide a further assessment of the evidence base, explore the limitations of the estimates of death that have been made, and calculate the population risk of mild valvular regurgitation and hospitalisation attributable to benfluorex use. We conclude that the previously published estimates of deaths attributed to the use of this agent are unsafe, based on unfounded assumptions, and are highly likely to be inaccurate.
PubDate: Sun, 22 Dec 2013 13:22:22 +000
- Robust Medical Test Evaluation Using Flexible Bayesian Semiparametric
Abstract: The application of Bayesian methods is increasing in modern epidemiology. Although parametric Bayesian analysis has penetrated the population health sciences, flexible nonparametric Bayesian methods have received less attention. A goal in nonparametric Bayesian analysis is to estimate unknown functions (e.g., density or distribution functions) rather than scalar parameters (e.g., means or proportions). For instance, ROC curves are obtained from the distribution functions corresponding to continuous biomarker data taken from healthy and diseased populations. Standard parametric approaches to Bayesian analysis involve distributions with a small number of parameters, where the prior specification is relatively straight forward. In the nonparametric Bayesian case, the prior is placed on an infinite dimensional space of all distributions, which requires special methods. A popular approach to nonparametric Bayesian analysis that involves Polya tree prior distributions is described. We provide example code to illustrate how models that contain Polya tree priors can be fit using SAS software. The methods are used to evaluate the covariate-specific accuracy of the biomarker, soluble epidermal growth factor receptor, for discerning lung cancer cases from controls using a flexible ROC regression modeling framework. The application highlights the usefulness of flexible models over a standard parametric method for estimating ROC curves.
PubDate: Wed, 11 Dec 2013 09:16:47 +000
- Behavioural Risk Factors of Noncommunicable Diseases among Nepalese Urban
Poor: A Descriptive Study from a Slum Area of Kathmandu
Abstract: There has been a rapid rise in the burden of noncommunicable diseases in low-income countries like Nepal. Political and economical instability leading to internal migration give rise to haphazard urbanization in Nepal. This, coupled with negative effects of globalization, is largely responsible for changing lifestyle and developing risky behaviour among the urban poor that put them at high risk of developing noncommunicable diseases. A descriptive cross-sectional quantitative study was conducted from September to December 2012 in an urban slum of Kathmandu to explore the prevalence of four major behaviour risk factors namely physical inactivity, low fruit and vegetable consumption, and tobacco and alcohol use and to measure the burden of obesity and hypertension in the population. We used WHO NCDs Risk Factor steps 1 and 2 questionnaires in all the 689 households of the slum. The major behavioral risk factors for noncommunicable diseases were very common with at least a quarter of the population having the major risk factors. The results may serve to form a framework to future planning, policy-making, implementation, and evaluation of any measures undertaken to reduce these risk factors, especially as the government is planning to unveil the National Urban Health Policy soon.
PubDate: Mon, 04 Nov 2013 10:36:01 +000