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International Journal of Medicine and Medical Research
Number of Followers: 2  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2413-6077 - ISSN (Online) 2414-9985
Published by Ternopil State Medical University Homepage  [5 journals]
  • ENDOTHELIAL DYSFUNCTION AND CARDIOVASCULAR RISK IN PATIENTS WITH
           ANKYLOSING SPONDYLITIS

    • Authors: S. I. Smiyan, B. O. Koshak, I. V. Gnatko
      Abstract: Background. Ankylosing spondylitis is a disease that induces damage to the musculoskeletal system. Mortality rate among patients with AS is in 1.5 times higher than the population level. It is caused by cardiovascular disease and chronic renal failure.Objective. The research was aimed to study the prevalence of endothelial dysfunction and to establish its dependence on the factors of cardiovascular risk in patients with AS.Methods. 104 patients with ankylosing spondylitis (AS) were examined using standard diagnostic methods, such as disease activity, lipidogram, ultrasound of the carotid artery intima media, and endothelium vasodilatation in response to reactive hyperaemia was evaluated. Clinical activity of the disease was determined using the disease activity index BASDAI, BASFI functional index, index BASMI metrology, ASQoL quality of life. To estimate the 10-year risk of cardiovascular disease, the QRISK scale was used.Results. Endothelial dysfunction (ED) was found in 47% cases. It was established that in the patients with ED<10% the incidence of LPL>1.7 mg/L, HDL-C<1.0 mmol/L, TIM thickening>0.9 mm was higher than in the patients with ED>10%. In this group of patients, significant duration of the disease and essential differences in their progress in terms of VAS, CRP,  ESR, index activity and functional disorders were revealed.Conclusions. The problem of CVD in patients with AS may be caused by systemic inflammatory disease associated with the development of endothelial dysfunction and increased levels of atherogenic lipids.
      PubDate: 2017-12-29
      DOI: 10.11603/ijmmr.2413-6077.2017.2.7935
       
  • SERUM SOLUBLE CD25 IN HEPATOCELLULAR CARCINOMA, SHALL WE BE ABLE TO CHANGE
           THE NATURAL HISTORY'

    • Authors: E. A. Sameea, T. Zakareya, K. Metwaly, A. A.-R. Youssef, H. M. Kamal, W. M. Abdalla
      Abstract: Background. Although hepatocellular carcinoma (HCC) is one of the most common malignancy related mortality worldwide, it can be curable if detected in early stages. Emergence of a new marker that can early detect HCC could help in early treatment and therefore ameliorate the outcome.Objective. The aim of the research is to evaluate the performance of serum soluble CD25 (sCD25) in the prediction of early HCC and compare it to α-fetoprotein (AFP).Methods. Serum levels of sCD25 and AFP were measured in three groups of population; HCC group (40 patients), cirrhosis without HCC control group (20 patients) and healthy control group (20 patients). HCC group contained 20 early and 20 late stage patients according to Barcelona Clinic Liver Cancer (BCLC) staging system (stage 0/A and B-D respectively). Levels of both biomarkers were compared in all groups. Predictive yield of both biomarkers for early HCC was evaluated using ROC curve analysis.Results. Level of sCD25 was significantly higher in patients with HCC than in both cirrhotic controls and healthy controls (P<0.0001and 0.013 respectively). For prediction of early HCC in patients with cirrhosis, the optimal sCD25 cut-off level was 7.15 ng/ml with sensitivity and specificity of 90% and 60% respectively (AUC=0.717; P=0.019) while sensitivity and specificity of AFP were 70% and 85% respectively at a cut-off value of 9.85 ng/ml (AUC=0.781; P=0.002) in the same settings.Conclusion. sCD25 seems to be a reliable biomarker for early detection of HCC and therefore could enhance the outcome. 
      PubDate: 2017-12-29
      DOI: 10.11603/ijmmr.2413-6077.2017.2.8009
       
  • LEFT VENTRICULAR DIASTOLIC DYSFUNCTION AND OXYGEN SUPPLY OF LOWER
           EXTREMITIES IN PATIENTS WITH STABLE ISCHEMIC HEART DISEASE AND CONCOMITANT
           TYPE 2 DIABETES MELLITUS

    • Authors: N. I. Yarema, N. V. Pasyechko, A. I. Khomitska, I. P. Savchenko, I. V. Smachylo, L. V. Naumova, L. V. Radetska, A. O. Bob, M. E. Havrylyuk, O. O. Bob, N. M. Havrylyuk, O. I. Kotsyuba
      Abstract: Background. The peculiarities of diastolic heart failure and indices of arterial and venous blood oxygenation in patients with stable ischemic heart disease and concomitant type 2 diabetes mellitus are presented in the article. Obvious left ventricular diastolic dysfunction with the increased levels of natriuretic peptide, uric acid and decreased indices of arterial and venous blood oxygenation in the presence of comorbid type 2 diabetes mellitus have been revealed.Objective. The research was aimed to study the peculiarities of left ventricular diastolic function disorders, levels of NT-proBNP, uric acid and indices of arterial and venous blood oxygenation in patients suffering from stable exertional angina with underlying comorbid type 2 diabetes mellitus.Methods. 70 patients with IHD: stable exertional angina of the ІІІ functional class, were examined. The first group comprised 39 patients with stable exertional angina of the ІІІ functional class with left ventricular diastolic dysfunction; the second group – 31 patients with stable exertional angina of the ІІІ functional class with left ventricular diastolic dysfunction and concomitant type 2 diabetes mellitus. All the examined patients underwent BD- echocardioscopy, with the detailed evaluation of left ventricular diastolic function, NT-proBNP and uric acid levels in venous blood were determined by immunoenzyme method, indices of arterial and venous blood oxygenation were evaluated too.Results. The correlation between left ventricle diastolic function and oxygen volume consumed by the tissues of lower extremities in patients with stable ischemic heart disease and concomitant type 2 diabetes mellitus was determined.Conclusions. In patients with stable IHD, left ventricular diastolic dysfunction and concomitant type 2 diabetes mellitus the levels of NT-proBNP, uric acid and oxygen supply of lower extremities are significantly higher as compared to patients with IHD without type 2 diabetes mellitus.
      PubDate: 2017-12-29
      DOI: 10.11603/ijmmr.2413-6077.2017.2.8242
       
  • CHOICE OF TREATMENT OPTIONS FOR CYSTIC LYMPHSTIC MALFORMATIONS IN THE HEAD
           AND NECK REGION: TREATMENT EXPERIENCE OF 81 CHILDREN

    • Authors: I. M. Benzar
      Abstract: Background. Surgery has previously been the only treatment for lymphatic malformations (LMs), but in the head and neck region is challenging due to the risk of scarring, nerve damage, recurrence. Sclerotherapy may be a perfect alternative.Objective. The aim of the study is to determine the efficacy and safety of the OK-432 sclerotherapy in the children with craniofacial LMs.Methods. 81 children with head and neck LM between December 2010 and March 2017were involved into the study. The follow-up period was from 6 to 79 months. According to the size of cysts, LMs were classified into macrocystic, microcystic, and mixed. The result of the treatment of LMs was determined by the percentage of reduction in size as excellent (decrease by more than 90%), good (by 50%-89%), satisfactory (by 20%-49%) and none (by less than 20%).Results. The macrocystic LMs diagnosed in 41.97% of patients, microcystic - in 12.35%, and mixed – in 45.68% of children. OK-432 sclerotherapy only was performed for 83.9% of patients and in 12.3% in combination with surgery. The range of sclerotherapy sessions was from 1 to 11. An excellent result in 96.97% of cases was evidenced in the patients with macrocystic LM. Poor result was proved in the patients with microcystic LMs; the most of them (55.56%) had satisfactory result. In the patients with mixed LM, an excellent and good result was evidenced in 83.33%. After 198 sessions of OK-432 sclerotherapy, complications associated with the treatment occurred in 5 (2.52%) cases.Conclusions. OK-432 sclerotherapy is a safe and effective treatment of head and neck LMs in children. Macrocystic LMs proved the best response to OK-432 treatment.
      PubDate: 2017-12-29
      DOI: 10.11603/ijmmr.2413-6077.2017.2.8381
       
  • CHARACTERISTIC FEATURES OF MULTIPLE ORGAN FAILURE IN CASES OF PERITONEAL
           SEPSIS

    • Authors: L. Yu. Ivashchuk, I. B. Pizhitsky
      Abstract: Background. The study of hystomorphology of liver and small intestine in experimental peritonitis is presented. Due to this information the criterion of pathogenetic moment transition SIRS for peritoneal sepsis was determined.Objective. The aim of the research was to study the morphology of terminal part of small intestine and liver in cases of experimental peritonitis.Methods. For histological and electron microscope study the biopsy of liver, small intestine were taken; the samples were stabilized in a neutral formalin, dried in alcohol of increasing concentration and placed in paraffin. Paraffin sections were painted with hematoxylin and eosin and studied under the light-optical microscope.Results. Apoptosis caused damage to enterocytes and hepatocytes of first bacterial translocation. Mechanism of vasodilatation effect of NO and its effect on apoptosis were determined. Septic shock was accompaniment of two main levels of body cells damage: apoptosis and membranes destruction. Peritoneal sepsis is a grave condition caused by progressive peritonitis and polyorgan insufficiency syndrome. The phases of peritonealis sepsis pathogenesis were defined.Conclusions. The presented morphological criteria prove the initiation of apoptosis within 24 hours after the development of peritonitis in enterocytes and hepatocytes.
      PubDate: 2017-12-29
      DOI: 10.11603/ijmmr.2413-6077.2017.2.7917
       
  • ANTENATAL INVESTIGATION OF DUCTUS VENOSUS VELOCITY AS A METHOD OF
           DETECTING THE FETAL HEART FAILURE, CAUSED BY PARVOVIRUS B19 INFECTION

    • Authors: N. P. Bondarenko, A. V. Aksonova
      Abstract: Background. The article describes the methods and results of investigation of blood flow velocity waveforms in fetal ductus venosus (DV). These studies are used to visualize the degree of fetal heart failure and determine its further clinical course.Objective. The study was aimed to predict the development of heart failure in the fetuses that were infected with parvovirus B19 infection during 11-14 gestation weeks by measuring the Doppler parameters of blood flow velocity in the DV.Methods. Our investigation involved 20 pregnant women aged from 18 to 30 years old who were infected with parvovirus B19 infection during the period from 11 to 14 weeks of gestation. The DV was determined by means of color Doppler. Fetal echocardiography (EchoCG) was performed by means of the ultrasound scanner Philips HD IIXE device (USA) using a transabdominal convex probe with the frequency of 3.5 MHz, operating in a CDC mode and the frequency filter at 100 Hz. The A-wave directivity evaluation in the DV was investigated according to the Guideline Principles of the Fetal Medicine Foundation (www.fetalmedicine.com). Statistical processing of data was carried out using the package of applied programs Microsoft Office Excel 2016 and Statistica 6, Stata 12.Results. In 16 of 20 (80%) fetuses we did not observe any absent or reversed A-wave flow in the DV during atrial contraction as well as any fetal echocardiographic pathological signs. In 2 (10%) cases a reversed A-wave flow in the DV in a combination with EchoCG-signs of overload of left side of heart, resulting in enlargement (dilatation) of left atrium and left ventricle were detected. In 2 (10%) cases the presence of a reversed A-wave flow in the DV and EchoCG-signs of fetal heart failure (reduction of cardiac output, significant dilatation of left ventricle) were evidenced.The results of the study confirm that with the expansion of fetal nuchal translucency thickness, the systolic blood flow velocity in the DV increases with the correlation coefficient r=0.594, which proves a linear dependence between these two ultrasonography parameters.Conclusions. The linear correlation between the presence of a reversed A-wave blood flow velocity in the DV and the overload of left side of fetal heart, development of heart failure (20% of the total number of examined women) were proved.
      PubDate: 2017-12-29
      DOI: 10.11603/ijmmr.2413-6077.2017.2.8396
       
  • BIOMETRIC METHOD OF AGE ESTIMATION: DEVELOPMENT AND EFFICIENCY, IN CASES
           OF PATHOLOGIES OF TEETH HARD TISSUES

    • Authors: M. Yu. Honcharuk-Khomyn, Kh. V. Pohoretska, L. O. Patskan
      Abstract: Background. The physiological changes of tooth are the criteria used in evaluation of regressive formula by Kvaal et al. age estimation technique. But in cases of abnormal occlusion, abnormal chewing habits, bruxism, abrasive factors or structural defects of teeth the intensity of tooth aging accelerates.Objective. The aim of the research was to define the options of age estimation according to dental state of individuals with pathological attrition.Methods. 108 panoramic x-ray photos of patients with pathological attrition of teeth were chosen by a randomized selection (49 males and 59 females). All photos were made by means of Planmeca PROMAX orthopantomograph. Nine measurements were made for each tooth: the tooth length, pulp length, root length, root width and pulp width at three different levels: cement-enamel junction (level A, beginning of root), one-quarter of root length from a cement-enamel junction (level B), and mid-root (level C). Due to these measurements, a number of ratios were calculated in accordance with Kvaal et al. method.Results. The errors that reached 27±8.4 years were found when evaluating the dental age using primary coefficients of equations suggested by the authors of the method used. By means of mathematical analyses, principal component regression method as well, the correlation coefficient of Pearson and method of combining linear regression due to the tooth changes in cases of pathological attrition (lowering level of occlusal surface, dystrophy of pulp structures and deposition of tertiary reparative dentine) by regression analysis, the modified formulas for age estimation using radiographic technique were found. Modified coefficients decreased the error to 13±0.8 years, which was relative to the real age upto nearly 42-48% compared to the primary coefficients of equations for pathological attrition.Conclusions. Age estimation technique can be improved taking into account morphological changes in pathological attrition and the calculated coefficients make it possible to expand the circle of person’s age which needs to be found.
      PubDate: 2017-12-29
      DOI: 10.11603/ijmmr.2413-6077.2017.2.8228
       
  • PANRESISTANT SUPERBUGS: ARE WE AT THE EDGE OF A ‘MICROBIAL
           HOLOCAUST’

    • Authors: I. D. Khan, K. S. Rajmohan, A. K. Jindal, R. M. Gupta, S. Khan, M. Shukla, S. Singh, Sh. Mustafa, A. Tejus, S. Narayanan
      Abstract: Contemporary healthcare has progressed towards world health security through advancements in medication-based and surgical interventions, supported by the success of antimicrobial therapy. The emergence of panresistant infectious diseases is becoming a public health problem worldwide. Panresistance is attributable to a complex interplay of antimicrobial overuse in healthcare facilities due to lack of regulatory commitment in the backdrop of natural mutations in pathogens and rise in immunocompromised hosts. Developing countries are facing the brunt in epidemic proportions due to strained public health infrastructure and limited resource allocation to healthcare. Panresistance is a biological, behavioural, technical, economic, regulatory and educational problem of global concern and combating it will require concerted efforts to preserve the efficacy of the available antimicrobials. An intensified commitment needs to be taken up on a war footing to increase awareness in the society, increase laboratory capacity, facilitate antimicrobial research, foster emphasis on infection control and antimicrobial stewardship, and legislation on manufacturing, marketing and dispensing of antimicrobials.
      PubDate: 2017-12-29
      DOI: 10.11603/ijmmr.2413-6077.2017.2.8012
       
  • ACETAMINOPHEN EFFECT ON FREE RADICAL OXIDATION INDICES IN RATS WITH TYPE 2
           DIABETES MELLITUS

    • Authors: O. B. Furka, I. B. Ivanusa, M. M. Mykhalkiv, I. M. Klishch
      Abstract: Background. Acetaminophen is a drug used to relieve pain syndrome. It is used both independently and in composition of combined drugs. Type 2 diabetes is an age-related disease that is associated with a violation of insulin synthesis by pancreas.Objective. The aim of the research was to study the effect of acetaminophen on major free radical oxidation indices of rats with type 2 diabetes mellitus in time dynamics.Methods. We conducted two series of experiments. The first series comprised rats with type 2 diabetes mellitus and acute acetaminophen toxic lesions. The second series involved rats with type 2 diabetes mellitus and acetaminophen administration at a dose of 55 mg/kg for the period of 7 days.Results. Administration of acetaminophen for rats with type 2 diabetes mellitus caused the increase in the content of malondialdehyde, diene and triene conjugates and Schiff bases in blood plasma and malondialdehyde, diene and triene conjugates in liver homogenate. The maximum increase in these indices was observed on the first day of the experiment. Gradually these indices decreased on the 3rd, 5th and 7th days of the experiment.Conclusions. Free radical oxidation increased in both series of the experiment. This process developed in rats with type 2 diabetes mellitus and acute acetaminophen toxic lesions more intensively, than in rats with type 2 diabetes mellitus and administration of acetaminophen at the highest therapeutic dose during 7 days.
      PubDate: 2017-12-29
      DOI: 10.11603/ijmmr.2413-6077.2017.2.8372
       
  • ECOLOGICAL FEATURES OF MICROBIOCENOSIS OF THE SKIN OF MAMMARY GLANDS AND
           VAGINA IN PREGNANT WOMEN WITH THREAT OF PRETERM LABOR

    • Authors: V. Ya. Ivankiv, I. M. Malanchyn, N. I. Tkachuk
      Abstract: Background. The threat of preterm birth is one of the most topical issues in the world medicine. According to the statistics, from 12-13 to 25-35 % of all pregnancies end prematurely. One of the causes of preterm labour is chronic inflammatory processes of female genital organs and disorder of microbiocenosis. Timely diagnosis and adequate treatment will reduce the risk of premature labour and avoid perinatal loss.Objective. We examined and analysed the microflora of the skin of mammary glands and mucous membrane of vagina in healthy pregnant women and patients with threat of preterm labour.Materials and methods. The examination of the pregnant was conducted at the TRMPC “Mother and Child” in several stages. First of all, we rinsed the skin of mammary glands and smeared from mucous membrane the posterior vault of vagina with sterile swabs pre-moistened in physiological solution. After that, the tampons were placed in sterile tubes and delivered to laboratory. Sowing was carried out on Petri dishes with sterile medium: ZHSA, bloods MPA, Endo, Saburo, thioglycolic medium.Conclusions. As a result of the research we found saprophytic Gram-positive and Gram-negative microorganisms (in women with a physiological course of pregnancy). In pregnant women with preterm labour, there was the increase in the number of St. haemolyticus from 13% to 87%, appearance of representatives of pathogenic flora – St. aureus (in 20%).
      PubDate: 2017-12-29
      DOI: 10.11603/ijmmr.2413-6077.2017.2.8077
       
  • NANOTUBS INCREASE TETRACHLOROMETHANE INDUCED OXIDATIVE STRESS

    • Authors: N. Ya. Letniak, I. P. Kuzmak, M. M. Korda
      Abstract: Background. The unique physical and chemical properties of carbon nanotubes determine wide-ranging prospects for their use in biology and medicine. The capability of nanotubes to transport medicines and chemicals inside a cell makes the possibility of classical toxicants toxicity increase in case of their intake to the body with nanotubes, an urgent issue.Objective. The aim of the research was to study the effect of carbon nanotubes on the capability of the chemical toxicant tetrachloromethane (TCM) to induce oxidative stress in serum and liver of rats.Methods. The experiments were performed on outbred male rats, which were administered intraperitoneally with 0.5 ml of suspension of single-walled, multi-walled or multi-walled functionalized COOH nanotubes (60 mg/kg) only or together with TCM (2 ml/kg). The animals were taken out of the experiment in 3, 6 and 48 hours after the administration of the nanotubes and TCM. The activity of catalase, superoxide dismutase, the content of thiobarbituric acid reactive substances (TARS), reduced glutathione, ceruloplasmin and total antioxidant activity of serum were determined in serum and liver.Results. It was established that under the influence of multi-walled carbon nanotubes the studied parameters changed significantly. The administration of tetrachloromethane to rats caused significant changes in all indicators. Maximal changes in the rates were recorded in the group of animals that were administered with carbon nanotubes and tetrachloromethane togeather. In this case, a number of the studied parameters of blood and liver significantly changed compare to the similar indicators of the group of animals, which were administered with the chemical toxicant only.Conclusions. Carbon nanotubes increase the capability of the chemical toxicant tetrachloride to cause oxidative stress in liver and serum.
      PubDate: 2017-12-29
      DOI: 10.11603/ijmmr.2413-6077.2017.2.8416
       
  • CHRONIC ENTEROCOLITIS COMBINED WITH STREPTOZOTOCIN-INDUCED DIABETES IN
           RATS: MECHANISM OF OXIDATIVE STRESS DEVELOPMENT

    • Authors: N. V. Lisnianska, M. I. Маrushchak, I. V. Antonyshyn, O. P. Mialiuk
      Abstract: Background. Despite numerous studies on chronic inflammatory processes in colon, the complex problem of chronic enterocolitis (CEC) remains relevant.Objective. The aim of the research is to evaluate the lipid peroxide oxidation and antioxidant defence system in rats suffering from chronic enterocolitis development with underlying streptozocine-induced diabetes mellitus.Methods. The study involved 106 white non-linear male rats. Diabetes mellitus (DM) was modeled by a single intraperitoneal administration of streptozotocin to animals (Sigma Aldrich, USA, at a dose of 60 mg/kg of body weight). CEC was induced by a free access of animals to 1.0% solution of carrageenan in drinking water for 1 month.Results. In the wall of small intestine of DM rats, lipid peroxide oxidation increases and the activity of enzyme link of antioxidant defence decreases reliably. The course of experimental CEC in rats is accompanied by the increase in free radical oxidation in the wall of small intestine and simultaneous increase of enzyme activity of antioxidant defence system, compared to the control.In cases of CEC with underlying DM in rats, the development of oxidative stress in the wall of small intestine is caused by the statistically significant increase in levels of diene conjugates and thiobarbituric acid reactive substances, (p<0.01) and the decrease in activity of SOD and catalase.Conclusions. The activation of free radical reactions is an important non-specific mechanism of inflammation development in tissues of small and large intestine in cases of diabetes mellitus.
      PubDate: 2017-12-29
      DOI: 10.11603/ijmmr.2413-6077.2017.2.8035
       
  • AGE-RELATED MORPHOMETRIC CHARACTERISTICS OF REMODELING OF ARTERIAL BED OF
           HIND LIMBS IN WHITE RATS WITH EXPERIMENTAL HYPERCHOLESTEROLEMIA

    • Authors: I. I. Yuryk, Ya. Ya. Bodnar, V. D. Voloshyn, Ya. I. Yuryk
      Abstract: Background. The human organism is constantly affected by metabolic risk factors. All of them for a long time are asymptomatic and often form in early childhood long before clinical manifestations. However, morphogenesis and morphofunctional features of age-related structural changes in blood vessels of different sites are poorly studied.Objective. To evaluate the morphometric characteristics of arterial bed remodeling of hind limbs in white rats of PRA and RA with experimentally induced hypercholesterolemia.Methods. The tissues biopsies from femoral, knee and shin areas were studied by means of histological and morphometric methods.Results. Experimental hypercholesterolemia caused remodeling of vessels with increasing thickness of medial and endothelial layer of vessels in the investigated parts of the rats’ body. In this case, the external diameter of vessels increased only in femoral area in the reproductive group of rats. In the group of pre-productive animals, the external diameter of the vessels studied was more or less unaffected. Thus, increased thickness of intima and media led to a decrease in arteries capacity. The depth of vascular lesions and the decrease in functional capacity of blood vessels were directly proportional to the duration of the experiment. In the group of reproductive rats, the changes in vascular bed were more evident.Conclusions. Objective study of the processes allows providing a scientific basis for further research and understanding of the pathomorphism of vascular diseases in humans.
      PubDate: 2017-12-29
      DOI: 10.11603/ijmmr.2413-6077.2017.2.8237
       
 
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