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Reproductive Endocrinology     Open Access   (Followers: 3)
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Reproductive Endocrinology
Number of Followers: 3  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2309-4117 - ISSN (Online) 2411-1295
Published by Trilist Publishing Homepage  [1 journal]
  • Endometrial polyps: optimization of anti-inflammatory therapy

    • Authors: Т. Ф Татарчук, Н. В. Косей, О. В. Занько, Т. І. Юско
      Pages: 8 - 14
      Abstract: The frequency of hyperproliferative pathology of endometrium is about 60–70% in the structure of gynecological pathology of postmenopausal women. Endometrial polyps are a fairly frequent gynecological pathology for women of all ages, but the overwhelming majority of them are diagnosed at the age of 40–60 years. According to a number of studies, the frequency of endometrial polyps is 39.2–69.3%, and the endometrial polyposis occupies the first place in the structure of intrauterine pathology in postmenopausal.Given the important role of inflammation in the etiology of endometrial polyps and the risk of infectious complications in the postoperative period, there is a need for a comprehensive approach to the examination and treatment of this pathology. To date, ultrasound diagnostics and hysteroscopy are considered the standard for diagnosing endometrial polyps. However, the use of hysteroscopic technique in postmenopausal patients has a number of limitations, which are primarily associated with the possible occurrence of anesthetic and surgical complications. With age in the body, women experience atrophic changes in the genital area, which are often the cause of the formation of stenosis and obliteration of the cervical canal, which increases the risk of injury during his burying and can lead to the formation of a «false» course and even perforation of the uterus. This causes a more complicated postoperative period, which is characterized by a pain syndrome, the presence of subfebrile, hematometry, etc. In addition, given the growth in postmenopausal frequency of extragenital pathology and metabolic syndrome, during the surgical interventions and in the postoperative period, the risk of thrombotic complications increases.The article presents the substantiation of the expediency of conducting anti-inflammatory therapy in the postoperative period in postmenopausal patients after hystero-rectoscopic removal of polyps. The risk of complications of inflammatory nature after hysteroscopy is quite high and is 3–10%. The expediency of using the combined treatment regimen of endometrial polyps in this patient population using the enzyme complex Distreptaza®, which reduces the severity and duration of the pain syndrome, reduces the risk of developing subfebrile and formation of hematometry.
      PubDate: 2018-12-28
  • The modern view on optimal therapy of HPV-associated pathology of cervix
           at the vaginal dysbiosis background

    • Authors: О. А. Таран, О. В. Булавенко, Д. Г. Коньков, Т. В. Лобастова
      Pages: 16 - 20
      Abstract: Human papillomavirus (HPV) is a proven cause of precancer and cervical cancer. Violation of the vaginal microbiota in women with HPV-associated cervical pathology may contribute to the development of carcinogenesis. Deficiency of lactobacillus contributes to the growth and development of opportunistic microorganisms, reducing the synthesis of bactericidal and antifungal substances.The study of the clinical efficacy of the vaginal Lactoginal® (strain Lactobacillus rhamnosus LCR35), in the complex treatment of HPV-associated cervical pathology at the vaginal dysbiosis background’s.The results of the study showed a significant decrease in cases of vaginal dysbiosis, an increase in the number of lactobacilli in the vaginal secretion, a decrease in the microbial associations of relative pathogenic flora, an improvement in local immunity and complete elimination of HPV with the addition of the Lactoginal® to the basic therapy. The results obtained allow us to recommend the Lactoginal® for treatment of precancerous diseases of the cervix.
      PubDate: 2018-12-28
  • Reproductive, clinical and biological markers of perimenopause

    • Authors: О. О. Єфіменко, І. М. Ретунськ, О. С. Зеленько
      Pages: 24 - 28
      Abstract: The problems of aging women both in the world and in our country are becoming increasingly relevant. The sharp increase in the incidence among women of the age category, which coincides with the age of menopause, is a serious argument for considering this period and the associated changes as one of the priorities of modern medicine. Already today, despite the general tendency to aging of the population, a third of the life of the majority of women falls on the post-menopausal period, which acquires a special social and even state significance. However, these changes begin at a younger age, which requires close attention of specialists, because it is at this stage that the development of long-term programs to preserve both the reproductive and the general health of the female population is important.The article considers modern views on the problem of ovarian function diminishing in perimenopause and the problem of aging in general. Reproductive and biological age markers and hormonal disorders causing clinical manifestations of perimenopause are given. Attention is paid to the definition of psychological age, its influence on the psychological status of a woman whose passport age is over 40 years old, which coincides with the peak of her professional and social activities. Analyzed modern views on improving the quality of life of women who are in the perimenopausal period.Currently, there are many methods for timely assessment of disorders in systems and organs that can provoke the occurrence of age-related diseases. Therefore, the task of modern medicine is to prevent early aging and introduce preventive methods that improve the quality of life and increase its duration. As the authors of the article note, the assessment of biological and reproductive age is important for the prevention of diseases that can be avoided by following simple guidelines for optimizing lifestyle.
      PubDate: 2018-12-28
  • Modern views for the treatment of placental dysfunction in pregnant after

    • Authors: О. В. Кравченко
      Pages: 30 - 34
      Abstract: With the introduction of in vitro fertilization, the quantity of problems associated with the high incidence of obstetric and perinatal pathology in women with induced pregnancy have increased. The purpose of the study was to evaluate the effectiveness of complex therapy aimed at the prevention and treatment of placental dysfunction in pregnant women after in vitro fertilization.Under observation there were 23 pregnant women after in vitro fertilization (main group) and 20 women with physiological pregnancy (control group). Exclusion criteria from the study were multiple pregnancy, abnormal development of the female genital organs, severe extragenital pathology in mother, congenital abnormalities of the fetus.Considering the decrease in chorion vascularization, its hypoplasia, as well as hemodynamic disturbances in the myometrium at the end of the first trimester of gestation in pregnant women after IVF, it can be said with certainty that in addition to hormonal support in patients with induced pregnancy, therapy is aimed at normalizing uterine-chorial blood flow, restoration of effective embryo-chorial relationships.To this end, we have proposed a complex of therapeutic agents, which includes venotonic Normoven 1 tablet 2 times a day and Magnicum1 tablet 3 times a day. In order to activate metabolic processes in the body, the drug Arthiol was administered of 600–1200 mg per day before a meal. The treatment was performed twice at 10–12 and 15–18 weeks of gestation.The proposed complex of therapeutic agents helps to normalize uterine-chorial blood flow, restore effective embryo-chorial relationships, and significantly reduces the incidence of placental dysfunction in the future.
      PubDate: 2018-12-28
  • Hormonal status of patients after surgical treatment of fibrocystic

    • Authors: Ю. Я. Присташ
      Pages: 36 - 39
      Abstract: The purpose of the study was to investigate the efficacy of Mastodynon® in terms of indications in elevated doses versus the standard dose.Materials and methods. Data were analyzed for 60 patients after surgical treatment of fibrocystic mastopathy. Depending on the postoperative therapy received by the patients, they were divided into three equal groups. Patients of Group I were observed in accordance with the standards established in mammal practice and did not receive special agents that affect hormonal homeostasis. Patients of Group II in addition to observation received Mastodynon® (1 tablet or 30 drops 2 times a day) for 6 months. Patients of Group III were given for a postoperative rehabilitation Mastodynon® in a double dose (2 tablets or 60 drops 2 times a day) for 6 months.Results. Surgical treatment without conservative therapy eliminates organic changes in the breast, but hormonal disorders that have led to pathologic and histological changes in the tissues of breast continue to exist for a long time and can lead to repeated nodal formations. In group І, 25% of patients within 2 years performed repeated sectoral resections on recurrence of nodule formation. The use of Mastodynon® in standard doses (group II) for postoperative rehabilitation contributes to a significant improvement in hormonal homeostasis (normalization of prolactin, estradiol and progesterone levels), a 24.7 mm decrease in the degree of cyclic mastodynia according to the visual analog scale (VAS), and the improvement of ultrasound scan picture of breast in 75% of patients. The most pronounced effect of this rehabilitation approach after the surgical treatment phase was noted for the use of Mastodynon® in double doses (2 tablets or 60 drops 2 times a day) in Group III. In these patients, the degree of reduction of cyclic mastodynia was 30 mm for VAS and positive changes in the tissues of breast were noted in 85% of patients.Conclusion. Despite the presence of short-term side effects and rapid rebounding in the double-dose Mastodynon® group, our study showed better results than standard doses, faster and more stable therapeutic effect. Taking into account the results obtained, it can be argued that the use of high doses of Mastodynon® may be recommended to patients for the treatment of mastopathy.
      PubDate: 2018-12-28
  • Povidon-iodine (betadine) in modern obstetric-gynecological practice

    • Authors: О. М. Носенко, Т. Я. Москаленко, А. В. Рутинская
      Pages: 43 - 48
      Abstract: The article describes the pharmacocodynamics of povidone-iodine, the release form under the brand name Betadine, pharmacological benefits, as well as evidence of its effectiveness in preventing infection in the field of surgical intervention. Povidone-iodine is indicated to be a depot of iodine, constantly releasing elemental iodine, which has strong oxidizing properties, and therefore most microorganisms are destroyed in vitro in less than a minute, and the main destructive effect of the drug occurs in the first 15–30 seconds. Povidone-iodine has a wide spectrum of antimicrobial and antiviral action.The data on medications of povidone-iodine in the form of vaginal suppositories, antiseptic solution and ointment under the trade name Betadine are presented. Own data on the effective use of vaginal suppositories in symptomatic vaginal dysbiosis caused by mixed opportunistic bacterial flora (facultative and obligate anaerobes) with the presence of Atopobium vaginae in diagnostically significant amounts are presented.In the presented comparative studies, the advantages of Betadine compared with other antiseptics in the spectrum of microbiological effects, resistance of microorganisms, effects on wound healing, dependence of the effect on the physico-chemical parameters of the environment, side effects, the purpose of application – prevention and/or treatment are shown.The results of recent comparative studies on the treatment of the surgical area with chlohexidine-alcohol and povidone-iodine, according to which povidone-iodine should still be considered acceptable for the preoperative treatment of the caesarean section, are highlighted. It is indicated that the irrigation of the wound cavity with an aqueous solution of povidone-iodine during surgery and before suturing the surgical wound is one of the WHO recommendations for the prevention of infection in the field of surgical intervention.The authors conclude that povidone-iodine, including Betadine, has a broad spectrum of antimicrobial and antiviral activity; high activity in the presence of organic compounds (blood, pus); ability to penetrate through biofilms, necrotic tissue, eschar; low incidence of antiseptic resistance; positive dynamics of wound healing by preventing the spread of inflammation and increasing the ability to heal; well tolerated by patients; low cost; ease of use.
      PubDate: 2018-12-28
  • Review of international scientific data on the polyzhinax use in the
           treatment and prevention of vaginitis of different etiology

    • Authors: Е. Ф. Кира, А. М. Савічева
      Pages: 50 - 58
      Abstract: A significant prevalence of infectious-inflammatory diseases of female genital organs is one of the most urgent problems of gynecology. The combination of various bacterial and bacterial-fungal associations of microorganisms in the vaginal biotope leads to the formation of complex indistinct clinical manifestations, which complicates diagnosis. Incorrect diagnosis and inadequate treatment increase the frequency of vaginal infection relapses and contribute to prolonged course of the disease.Polygynax as one of the long-established drugs in Ukraine has not lost its significance despite the emergence in the national pharmaceutical market of an increasing number of drugs for local treatment and prevention of vulvovaginal infections. This medicinal product contains neomycin sulfate, polymyxin B sulphate and nystatin. The choice in its favor is based on a large array of accumulated data, which has shown its high efficiency and safety for the treatment and prevention of vulvovaginal infections in reproductive aged women.Based on the described in the article researches, the wide spectrum of the polygynax encompasses the main pathogens of bacterial and fungal vaginitis. Polygynax showed high efficacy against C. albicans strains, and especially in C. non-albicans resistant strains (including fluconazole resistant strains). Unlike oral medications, local treatment makes it possible to avoid the development of resistance to pathological microflora. Polygynax does not suppress normal vaginal flora and does not disturb its balance. Due to its characteristics, it is a drug of choice for local therapy of vaginitis. This is especially true in cases where, for a number of reasons, treatment should be initiated immediately, before obtaining the results of a microbiological study. In addition, the benefits of this drug should also include the simplicity and ease of use, the absence of absolute contraindications, the possibility of use in patients with extragenital pathology, in adolescents and postmenopausal women, and the local route of administration can reduce the pharmacological burden on the body.
      PubDate: 2018-12-28
  • Evaluation of Cicatridina efficacy in healing and repairing process of
           uterine cervix, vagina and vulva

    • Authors: Я. Марковська, А. Марковська, Р. Мадре
      Pages: 60 - 63
      Abstract: Purpose: The aim of the study was to evaluate the efficacy of Cicatridina® application in healing and repairing process after operative procedures concerning uterine cervix, vagina and vulva and after brachytherapy due to cervical and endometrial cancer. We also analyzed Cicatridina® effect on vaginal athrophical signs in post-menopausal women.Patients and Methods: The examined group consist of 319 women. They were divided into 2 arms. The active arm concerns 213 women who used Cicatridina®, while controlled one consists of 106 women. The effect of treatment was estimated after 6 weeks and 3 months by the visual inspection of the cervix and vagina. We also analyzed the subjective filling of patients bound to sexual intercouses by using of Visual Analogue Scale (0% – no effect; 100% – disappearance of pathological symptoms).Results: In active arm according to control one the reparation of cervix was more often: after surgery procedures (respectively after 6 weeks 93% vs 70%; after 3 months 99% vs 89%) and after brachytherapy(respectively after 3 months 86% vs 0%). In brachytherapy group the lack of discomfort during sexual intercourses was also more often in active arm (respectively 55% vs 0%). In postmenopausal women reduction of symptoms associated with atrophic vaginitis was observed only in active group (respectively after 6 weeks 43% vs 0%; after 3 months 57% vs 0%). In the group of patients after ephisiotomy due to delivery the relief of discomfort during sexual intercourses was also more often in active arm (respectively 94% vs 25%).Conclusion: Cicatridina® causes fast healing of cervix after gynecological procedures. It influences improvement of atrophical, inflammatory and after radiation therapy effects which improve quality of life and comfort of vagina after brachytherapy due to cervical and endometrial cancer. Cicatridina® causes similar effect in vagina of pos-menopausal women as locally used estrogens. Cicatridina® also causes the feeling of relief and comfort in vagina after delivery as well as fast healing after episiotomy.
      PubDate: 2018-12-28
  • Safety of drugs

    • Authors: А. А. Суханова, Ю. Н. Мельник, А. Б. Гордийчук
      Pages: 64 - 70
      Abstract: Liver is the main organ that plays an important role in the biotransformation of medicine in human body. Therefore, drug-induced liver injuries are much more common than official medical statistics show in different countries and on different continents. This circumstance is associated with many factors: the latent course of drug-induced liver injuries, inadequate interpretation of clinical symptoms and clinical laboratory parameters, insufficiently careful investigation of anamnesis, different frequency of use of various medicine in different countries.Drug-induced liver injuries are lesions that are associated with the use of medicine. Drug-induced liver injuries must be diagnosed as early as possible, as the continued administration of medicine can repeatedly exacerbate the severity of clinical manifestations and significantly affect the outcome of the disease as a whole. In addition, legal aspects are also important in this regard, since an unrecognized drug-induced liver injury with continued use of this medicine that allegedly caused this injury is a matter of a frequent professional investigations.The reaction of the liver on medicine depends on many factors: the initial state of liver function (already existing liver disease), heredity, gender, age, alcohol intake and other medicine. Presence of these factors in patients significantly increases the risk of development of liver injuries associated with taking medications, and if the drug-induced liver injury develops, the prognosis of its course will be heavier. Statistically-valid are frequent drug-induced liver injuries in women. The same type of medicine can cause different types of liver injuries in terms of clinical and morphological manifestations. Diagnostics of drug-induced liver injury is often difficult and requires from a specialist certain skills not only the necessity to carefully collect an anamnesis of a patient with a developed disease, but also a good orientation in his clinical and morphological manifestations.
      PubDate: 2018-12-28
  • Клинический случай анемии у пациентки с

    • Authors: Т. Ф Татарчук
      Pages: 72 - 73
      Abstract: Пациентка А., 29 лет, обратилась с жалобами на то, что на фоне частых головных болей и утомляемости («упадка сил») ее кожа стала сухой, а волосы и ногти – ломкими.
      PubDate: 2018-12-28
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Tel: +00 44 (0)131 4513762

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