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Publisher: Smart Science and Technology LLC   (Total: 21 journals)   [Sort by number of followers]

Showing 1 - 21 of 21 Journals sorted alphabetically
Abdomen     Open Access  
Cancer Cell & Microenvironment     Open Access   (Followers: 10)
Cardiovascular Regenerative Medicine     Open Access  
Evidence-based Medicine & Public Health     Open Access   (Followers: 8)
Immunoendocrinology     Open Access   (Followers: 1)
Inflammation and Cell Signaling     Open Access   (Followers: 3)
Itch & Pain     Open Access   (Followers: 2)
J. of Advanced Nutrition and Human Metabolism     Open Access   (Followers: 15)
Macrophage     Open Access  
Molecular & Cellular Epilepsy     Open Access   (Followers: 2)
Musculoskeletal Regeneration     Open Access   (Followers: 3)
Neurotransmitter     Open Access  
Precision Medicine     Open Access   (Followers: 2)
Receptors & Clinical Investigation     Open Access   (Followers: 1)
RNA & Disease     Open Access   (Followers: 1)
Science Proceedings     Open Access   (Followers: 1)
Stem Cell and Translational Investigation     Open Access   (Followers: 2)
Stem Cell Epigenetics     Open Access   (Followers: 3)
Telomere and Telomerase     Open Access  
Therapeutic Targets for Neurological Diseases     Open Access   (Followers: 1)
Uterus & Ovary     Open Access  
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Stem Cell Epigenetics
Number of Followers: 3  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2378-3095
Published by Smart Science and Technology LLC Homepage  [21 journals]
  • An effective mass-spectrometry- based strategy for characterizing histone
           H3K9 modifications

    • Authors: Ho-Geun Kwak, Naoshi Dohmae
      Abstract:  Mass spectrometry (MS)-based analytical approaches to examine histone post-translational modifications (PTMs) are useful tools to understand epigenetic function. Histone H3K9 methylation plays an important role in chromatin remodeling, which is important in stem cell self-renewal and differentiation. With a simple, rapid, and accurate top-down strategy using matrix assisted laser desorption/ionization (MALDI)-in source decay (ISD), we have recently identified K9 PTMs on H3 variants (H3.1, H3.2, H3.3, and H3t) in the mouse testis. Mono-, di-, and tri-methylated K9 sites were identified on H3 variants separated using liquid chromatography and an ion-pairing reagent. These modifications were also observed in the testis-specific histone H3 using MALDI-ISD. Our findings demonstrate a novel top-down approach for characterizing PTMs on histone tails that will have applications in future research. Keywords: MALDI-ISD, Testis-specific H3 histone, K9 modifications
      PubDate: 2017-02-06
      DOI: 10.14800/sce.1501
      Issue No: Vol. 4 (2017)
  • Antitumour effects of artichoke polyphenols: cell death and ROS-mediated
           epigenetic growth arrest

    • Authors: Anna Maria Mileo, Donato Di Venere, Stefania Miccadei
      Abstract:   Many epidemiological studies suggest that diet particulary rich in fruit and vegetables have cancer preventive properties. The beneficial effects of these diets are attributable, at least in part,  to polyphenols that have emerged as very promising anticancer bioactive compounds. We report that polyphenolic extracts from the edible part of artichoke show a potential chemopreventive and anticancer properties on several cancer cell lines. High dose of extracts of artichoke (AEs) reduced cell viability and inhibited cell growth in a dose dependent-manner. In particular AEs triggered apoptosis and modulate other tumour related features such as migration and invasion in highly metastatic breast cancer cells. In addition, we provide evidences that low dose of AEs-treatment inhibits breast cancer cell growth via the induction of premature senescence through epigenetic and ROS-mediated mechanisms. These findings demonstrated that high dose-AEs activate apoptotic machinery whereas low level treatment induce senescence in cancer cells. Since apoptosis and cellular pro-senescence are considered relevant anticancer therapeutic mechanisms, artichoke polyphenols extracts from the edible part, could be a promising dietary tool either in cancer chemoprevention or/and in cancer treatment as a non-conventional, adjuvant therapy.  
      PubDate: 2016-04-04
      DOI: 10.14800/sce.1242
      Issue No: Vol. 3 (2016)
  • Mitochondrial DNA alteration and pathological progression in colorectal

    • Authors: Jinhang Gao, Shilei Wen, Hongying Zhou, Shi Feng
      Abstract: Mitochondrion, the major organelle involved in cell energy metabolism, plays important roles in many human diseases. Nowadays, its dysfunction during initation and progression of cancers is calling more and more attention. Since Otto Warburg brought out his hypothesis, mitochondrial DNA (mtDNA) may affect on cancer development by regulating oxidative phosphorylation, many important findings have been discovered. It is widely recognized that research the potential correlations between mitochondrion and mtDNA in cancers are of great importance. And the trends of change of mtDNA content are different in different cancers. Thus leaves us numerous works to do. Although some cancers have already been reported their relation with mtDNA alteration, different experimental methods or evidence may lead to different conclusions. This article presents a brief in summarizing the mitochondrion dysfunction in human disease and the alteration of mtDNA in cancers. Moreover, the recent highlighting achievements on colorectal cancer and mtDNA are also summarized to provide a discussion on possible pathological mechanism and clinical usage.
      PubDate: 2016-01-18
      DOI: 10.14800/sce.1144
      Issue No: Vol. 3 (2016)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
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